UsTooArticles

Prostate Cancer Support Group - Richmond, Va

Meeting Dates - 3rd Thurs. each month - Time 7:00 PM - No July Meeting - The Dec. date will vary - Call for details - Peter C. Moon Phd. at 804-387-2151 between 7 - 11:00 PM - Location - Ridge Baptist Church, 1515 Eastridge Road Richmond, VA 23229

Vet

Rva Prostate Cancer Support Group

www.rvaprostatecancersupport.org

RVA

Articles Page

In good faith, this website was created to furnish you with helpful information. Nevertheless, no one who contributes or posts information to this website makes any guarantee regarding the information provided. Any decisions that you make regarding your health should be made in consultation with a qualified healthcare provider.

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Articles on Informed Decision Making

Prostate Cancer

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Website discussing how treatment results may be predicted by PSMA Scan Levels

US Too Warriors:

Warriors, my PSMA scan levels were low which suggest my cancer may not respond well to SBRT which I want to use if My cancer shows up on an Axumin scan that I have scheduled next Month at VCU so I am going to look for supplements or other ways to make my cancer better able to respond to SBRT.
Best
Peter

To read more on this subject:

Link: Treatment Sensitivity
or Go To
https://www.urologytimes.com/view/psma-levels-linked-to-tumor-biology-treatment-sensitivity-in-treatment-na-ve-prostate-cancer

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ADT treatment with Lupron lowers Testosterone towards Zero,
But Testosterone is needed block Brain Plaque to stop Alzheimer's

Us Too Warriors,

I am checking my free and total Testosterone to see if it is still high about 700 to 900. If not I may tryTestosterone patches but will keep an eye on my PSA to be sure it does not activate my PCa.

Best
Peter

Info:

Researchers are searching for a better way to understand why many men with prostate cancer end up with Alzheimer's disease, and whether it's the standard hormone therapy treatment or an overactive immune response that actually contributes to the problem.

Link 1 : " Testosterone"

or Go To

https://www.sciencedaily.com/releases/2024/08/240829132520.htm
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Paper - Website discussing the Concerns and process involved using Ferroptosis to treat cancers

Us Too Warriors,

My Personal concern is that excess IRON can weaken brain function but I have had anemia from my Psoriasis inflammation and my many blood draws so my iron supplements are needed to function well so far they have reduced my fatigue by reducing my Anemia as measure by my red blood cell level. I plan to do blood draws to check my iron levels in blood and anemia. When My Anemia disappears I will reduce/stop my iron supplement and try to use the iron in my body to continue Ferroptosis with just Casodex.

Best
Peter

Abstract:

Ferroptosis is a type of regulated cell death characterized by iron accumulation and uncontrolled lipid peroxidation, leading to plasma membrane rupture and intracellular content release. Originally investigated as a targeted therapy for cancer cells carrying oncogenic RAS mutations, ferroptosis induction now exhibits potential to complement chemotherapy, immunotherapy, and radiotherapy in various cancer types. However, it can lead to side effects, including immune cell death, bone marrow impairment, liver and kidney damage, cachexia (severe weight loss and muscle wasting), and secondary tumorigenesis. In this review, we discuss the advantages and offer an overview of the diverse range of documented side effects. Furthermore, we examine the underlying mechanisms and explore potential strategies for side effect mitigation.

Link 1 : "Ferroptosis"
or Go To
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-024-01999-9#Tab1
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Benefit of Reishi Mushrooms for fighting High cholesterol in fighting PCa and Heart disease

Us Too Warriors,

Cholesterol forms artery plaque in heart disease and the cell membrane as needed for fast growing cancer cells. Reducing Cholesterol is beneficial for heart health and slowing cancer. I recently added (last 3 months) Reishi mushroom supplement from Swanson as I thought it would slow my cancer. I just found online that it is the basis of the long life of Okanowians by reducing their heart problems in reducing cholesterol plaque.

I recently reported to you that myLDL had dropped from 130 to 76 which I attributed to my vitamin C infusion but in fact I had not had any infusions for about 4 months when this level of Cholesterol was measured but I had been taking Reishi Mushrooms pills1 to1.5 grams/d. Read below to find out more.

Best
Peter

Link 1 : "Reishi Mushrooms"
or Go To
https://www.webmd.com/diet/health-benefits-reishi-mushrooms

Histamine as a cause for PCa growth. Quercetin is a supplement to block this PCa grow & My Heart Afib & Immuno Psoriasis itch !

Us Too Warriors,

See the Article below.

Best
Peter

Abstract

Psoriasis is caused by a complex interplay among the immune system, genetic background, autoantigens, and environmental factors. Recent studies have demonstrated that patients with psoriasis have a significantly higher serum homocysteine (Hcy) level and a higher prevalence of hyperhomocysteinaemia (HHcy). Insufficiency of folic acid and vitamin B12 can be a cause of HHcy in psoriasis. Hcy may promote the immuno-inflammatory process in the pathogenesis of psoriasis by activating Th1 and Th17 cells and neutrophils, while suppressing regulatory T cells. Moreover, Hcy can drive the immuno-inflammatory process by enhancing the production of the pro-inflammatory cytokines in related to psoriasis. Hcy can induce nuclear factor kappa B activation, which is critical in the immunopathogenesis of psoriasis. There may be a link between the oxidative stress state in psoriasis and the effect of HHcy. Hydrogen sulfide (H2S) may play a protective role in the pathogenesis of psoriasis and the deficiency of H2S in psoriasis may be caused by HHcy. As the role of Hcy in the pathogenesis of psoriasis is most likely established, Hcy can be a potential therapeutic target for the treatment of psoriasis. Systemic folinate calcium, a folic acid derivative, and topical vitamin B12 have found to be effective in treating psoriasis.

Link 1 : "Histamine"
or Go To
https://pubmed.ncbi.nlm.nih.gov/31670376/
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Benefits of Reishi mushroom extract for health and fighting cancers

Us Too Warriors,

Please check out this website to see if you want to add this mushroom to your armentarian to battle cancer.

Best
Peter

Abstract:
Medicinal Mushrooms are rich sources of pharmacologically active compounds. One of the mushrooms commonly used in traditional Chinese medicine is Ganoderma lucidum (Leyss. Ex Fr.) Karst. In Asian countries it is treated as a nutraceutical, whose regular consumption provides vitality and improves health. Ganoderma lucidum is an important source of biologically active compounds. The pharmacologically active fraction of polysaccharides has antioxidant, immunomodulatory, antineurodegenerative and antidiabetic activities. In this review, we summarize the activity of Ganoderma lucidum polysaccharides (GLP).

Link 1 : "Medicinal Mushrooms"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400705/

Variation in ADT ( Lupron) use Continuous Vs Intermittent and patients weight are reported in this paper

Us Too Warriors,

Variation in ADT (Lupron) use Continuous Vs Intermittent and patients weight are reported in this paper

Best
Peter

Abstract:
As a clinical strategy, intermittent androgen deprivation therapy (IADT) has the potential to minimize adverse events associated with continuous androgen deprivation therapy while providing comparable efficacy for patients with advanced prostate cancer. Because most studies supporting IADT to date have been somewhat small and underpowered, additional large, randomized, controlled trials are needed before this strategy becomes the standard of care. However, the potential advantages of IADT, which include improved quality of life, the theoretical possibility of delaying hormone resistance, and possible reduction in expenses to the patient and health care payers, suggest it is a strategy worth further exploration.

Link 1 : "Lupron"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859136/
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"Cancer Today" website for back Issues

Us Too Warriors,

Cancer Today magazine that discusses cancer issues over all cancers that may be of help to you for your information.

Best
Peter

Link 1 : "Cancer Today"
or Go To
https://www.cancertodaymag.org/magazine-archives/

Electronic Version - ADVANCED PROSTATE CANCER NEWS

Us Too Warriors,

Please find Zero Cancer - Newsletter below for your information.

Best
Peter

Here is the link to the Electronic version of the Advanced Prostate Cancer Newsletter.

Some of you may have received this by mail - but here is a copy you can share!

https://online.flippingbook.com/view/1056063033/

Have a wonderful rest of the week!

Warm regards,

Terri

Link 1 : "Newsletter"
or Go To
https://online.flippingbook.com/view/1056063033/
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Melatonin for treating PCa and Vitamin K2 for Blocking Excess Bleeding

Us Too Warriors,

As shown in the paper below Melatonin has many possible ways of fighting PCa.

I have been using 40 mg of Melatonin every night for years . However, I also take vitamin K2 everyday at a medium dose of 300 mcg and at a mega dose (45,000mcg from Life extension) if I have bleeding occasionally from hemorrhoids. Melatonin at this 10 to 40 mg/nite and above is a blood thinner which along with all my blood draws can cause anemia and fatigue which make fighting cancer Hard. When I do not bleed much during the month my red blood levels are about 12.8 and are barely anemic at a below 13.0 and below the anemia level when I bled a lot during the month my red blood levels would drop to 11.0 or less.

It is hard to function, fight cancer when you are anemic.

Best
Peter

Abstract.

Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and experimental studies have documented that melatonin could inhibit different types of cancer in vitro and in vivo. Results showed the involvement of melatonin in different anticancer mechanisms including apoptosis induction, cell proliferation inhibition, reduction in tumor growth and metastases, reduction in the side effects associated with chemotherapy and radiotherapy, decreasing drug resistance in cancer therapy, and augmentation of the therapeutic effects of conventional anticancer therapies. Clinical trials revealed that melatonin is an effective adjuvant drug to all conventional therapies. This review summarized melatonin biosynthesis, availability from natural sources, metabolism, bioavailability, anticancer mechanisms of melatonin, its use in clinical trials, and pharmaceutical formulation. Studies discussed in this review will provide a solid foundation for researchers and physicians to design and develop new therapies to treat and prevent cancer using melatonin.

Link 1 : "Melatonin"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123278/

Zero cancer- Paper on Natural Herbs to Inhibit LSD1 causing Mutation
of P53 & thus protect of GENOME from Advanced Prostate Cancer

Us Too Warriors,

I recently sent you a paper showing that the U. of Michigan had developed a drug to Inhibit LSD1 that they are testing in a phase 1 clinical trial to stop NeuroEndocrine Prostate cancer which probably took Jerry Deans Life because he had a mutated P53 gene which until now has been untreatable with Standard of Care.

It may take 10 or more years before the drug U.of M. is FDA approved if ever?? Therefore I look for herbs to treat with that you will find in the next paragraph some which I found out I was already using.

The paper attached discusses the structure of herbal products that may inhibit LSD1 and protect men with NeuroEndocrine Prostate cancer. Many of these products are available on the internet by googling. Jerry Dean had extensive cancer for over twenty years and I have had it going on for thirty years which makes us more prone to NeuroEndocrine cancers. Fortunately I hope some of the herbs I have taken over the years may have protected me including ==>BioCurcumin, Berberine, Melatonin and Hesperidin among others discussed in the paper to follow. If you have been dealing with advanced cancer for 10 years or more with ADT standard of care especially if it has morphed into mCrPC, you may want to consider this paper carefully - Only about 3% of men have Neuroendocrine cancer when first diagnosed. However 20% of men with long PSA may develop NeuroEndocrine Prostate cancer Best for the holidays, Peter

I think I had talked Jerry into taking Berberine and Biocurcumin for a while but not at the level I was for a long time(years) 8 of 15 pills a day- I am down to 4 a day now as it becomes harder with age to take. But after reading this paper I am going up to 6 per day.

Best
Peter

Abstract.

Natural products generally fall into the biologically relevant chemical space and always possess novel biological activities, thus making them a rich source of lead compounds for new drug discovery. With the recent technological advances, natural product-based drug discovery is now reaching a new era. Natural products have also shown promise in epigenetic drug discovery, some of them have advanced into clinical trials or are presently being used in clinic. The histone lysine specific demethylase 1 (LSD1), an important class of histone demethylases, has fundamental roles in the development of various pathological conditions. Targeting LSD1 has been recognized as a promising therapeutic option for cancer treatment. Notably, some natural products with different chemotypes including protoberberine alkaloids, flavones, polyphenols, and cyclic peptides have shown effectiveness against LSD1. These natural products provide novel scaffolds for developing new LSD1 inhibitors. In this review, we mainly discuss the identification of natural LSD1 inhibitors, analysis of the co-crystal structures of LSD1/natural product complex, antitumor activity and their modes of action. We also briefly discuss the challenges faced in this field. We believe this review will provide a landscape of natural LSD1 inhibitors.

Link 1 : "Natural Herbs"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305746/#:~:text=isolated%206%20flavone%2Dbased%20natural,L)%20and%20reversibly%20inhibited%20LSD1

Zero Cancer- a new treatment for Endocrine PCa in Clinical trial

Us Too Warriors,

P53 is the protein called the Guardian of the GENOME. It keeps the cancer from Growing as long as it is not mutated and which can turn the PCa into the super aggressive form known as ENdocrine PCa which does not produce PSA and does not respond to the normal standard of care ADT treatments.

I know that Jerry Dean's P53 protein was mutated so it was no longer protecting him. He fought a gallant fight going to Duke, John Hopkins. New York and Chicago besides local radiation for treatments to give himself more time- I think he added at least two years.

It now appears the University of Michigan research has found a way to reverse the Mutation of P53 giving hope to us that I wish Jerry had. I miss having him as a guiding Light in our Group and Great Friend to All.

P53 understanding and function played a part in Nobel Prize awards because of its importance. The information from U of Michigan research on restoring P53 to Function to fight endocrine PCa cancer Follows below.

Best
Peter

Link 1 : "New Mechanism"
or Go To
https://www.sciencedaily.com/releases/2023/08/230814122244.htm

The use of Low Dose Naltrexone as adjunctive treatment to slow cancer

Us Too Warriors,

As I have reported, my PSA dropped 25% last month when for the last 3 1/2 years it has been doubling every 5 months or faster. In trying to see if I had done everything differently, I think it HAPPENED because I had added a low dose opioid inhibitor, called Low dose Naltrexone (LDN) at 4.5 mg/day. LDN=1.5 mg/day to 4.5 mg/day . As best as I can understand LDN acts to decrease opioids in your body so your body produces more because it thinks you are low. These opioids cause your cancer cells to be stuck in early S-phase of cell growth and not to traverse to G phase GROWTH as soon as possible, thereby slowing cancer growth.

On the other hand higher doses cause the cancer to grow. A paper is attached below that describes the effects of Ldn on cancers.

I order Naltrexone online( or by phone) from a website called "Ageless" Phone number = 1-650-503-9990 and paid a charge of about $ 70 for the prescription to the Doctor and I think paid less than $ 110 for the prescription pills good for 270 days!=810pills to the New Jersey pharmacy if you are interested. I have castration resistant PCa which developed on 2 1/2 years of CAsodex monotherapy(6yrs now in spite of not working) =poor man's Androgen receptor blocker which has allowed me to keep my testosterone so do not feel like an old man because I do not get Lupron shots = These shots are bad for heart, mind, muscles and mental function/outlook.

Call if you have questions-1-804- 387-2151 OR NEED TO TALK ABOUT ANY TREATMENT. I have a few more of these adjunctive treatments I use which I will put together for a January meeting of the RVa cancer Meeting.

Best
Peter

Link 1 : "Naltrexone"
or Go To
https://link.springer.com/article/10.1007/s12325-020-01591-9

Paper attached on Bipolar Androgen Treatment= BAT for CrPCa form John Hopkin's researchers a main source for this treatments

Us Too Warriors,

See the Link Below.

Best
Peter

Abstract:

Bipolar androgen therapy (BAT) is a new treatment concept for men whose prostate cancer has become resistant to standard hormone‐blocking therapy. Over the past decade, we have performed a series of clinical studies testing BAT in asymptomatic men with castration‐resistant prostate cancer. The key findings from these clinical studies are that BAT (a) can be safely administered to asymptomatic patients with metastatic castrate‐resistant prostate cancer; (b) does not produce symptomatic disease progression; (c) produces sustained prostate‐specific antigen and objective responses in 30%–40% of patients; and (d) can resensitize and prolong response to subsequent antiandrogen therapy. The concept of BAT has generated significant interest from men with prostate cancer, their families, and their physicians. Here we provide a “Patient's Guide” that answers questions about BAT in a form that is accessible to patients, their families, and physicians. Our goal is to provide information to help patients make the most informed decisions they can regarding their prostate cancer treatment.

Link 1 : "BAT"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313844/

Effect Of Sugar On Immunotherapy

Us Too Warriors,

Does sugar affect Immunotherapy? Using mouse models and data from human patients, the researchers found a direct relationship between the amount of sugar that a tumor consumes and the effectiveness of immunotherapy. The more sugar the tumor consumed, the less effective the immunotherapy.(Feb 17, 2021)

What supplements help immunotherapyVitamin A, beta-carotene, folic acid, vitamin B12, vitamin C, vitamin D, riboflavin, iron, zinc, and selenium may all have immunomodulating functions and could enhance the immune response rates of immunotherapy and even reduce irAEs[89]. They play an important role in reducing oxidative stress in diseases and cancers.Sep 24, 2021
See Paper Below

Best
Peter

Abstract:

Immunotherapy is now commonly prescribed to cancer patients, but autoimmune-related adverse events are considerable. For severe, life-threatening side effects, cessation of therapy seems unavoidable, let alone intensive medical care required for patching up the adverse events. Even without serious adverse events, the response rates are too low and various combinatory regimens have been tried. However, toxicities are also added on, unless the adjuvant agents have remarkably few side effects. Actually, micronutrients are usually taken by a majority of cancer patients as nutritional support or to boost the immune function, let alone hoping to counteract treatment side effects. Recent studies have shown that combinations of micronutrients exert pleiotropic effects in controlling tumor growth and metastasis by modulating the tumor microenvironment, enhancing gut microbiota immune functions, and providing adjunct nutritional support to micronutrient deficient cancer patients. A higher than recommended dietary allowance micronutrient dose is proposed to reduce the toxic free radicals generated as a result of immunotherapy and tumor metabolism. This is not only helpful for managing treatment side effects but also enhancing treatment efficacy. As micronutrient supplementation is also useful to improve patients’ quality of life, prolong survival, and sustain compliance to immunotherapy, further investigations are mandatory.

Link 1 : "Sugar"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479349/#ress%20in%20diseases%20and%20cancers
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Paper attached on Repurposed Drugs to improve Immune system to Fight PCa

Us Too Warriors,

I am presently using Metformin and Zinc to improve my Immune system. Metformin is a prescription used for diabetes to help control sugar. I do not have diabetes but it has no side effects as long as your sugar level does not drop below 70. The zinc supplement stimulates your thyroid gland to produce " "t" immune cells to fight cancer by increasing thymosin α1 (thymosin α1 decrease with age and that is one reasons it is thought more cancer shows up as we age) as discussed in the attached paper - see website below..
See Paper Below

Best
Peter

Abstract:

Cancer remains a significant global health challenge with limited treatment options beyond systemic therapies, such as chemotherapy, radiotherapy, and molecular targeted therapy. Immunotherapy has emerged as a promising therapeutic modality but the efficacy has plateaued, which therefore provides limited benefits to patients with cancer. Identification of more effective approaches to improve patient outcomes and extend survival are urgently needed. Drug repurposing has emerged as an attractive strategy for drug development and has recently garnered considerable interest. This review comprehensively analyses the efficacy of various repurposed drugs, such as transforming growth factor-beta (TGF-β) inhibitors, metformin, receptor activator of nuclear factorκB ligand (RANKL) inhibitors, granulocyte macrophage colony-stimulating factor (GM-CSF), thymosin α1 (Tα1), aspirin, and bisphosphonate, in tumorigenesis with a specific focus on their impact on tumor immunology and immunotherapy. Additionally, we present a concise overview of the current preclinical and clinical studies investigating the potential therapeutic synergies achieved by combining these agents with immune checkpoint inhibitors

Link 1 : "Repurposed Drugs"
or Go To
https://www.cancerbiomed.org/content/cbm/early/2023/11/06/j.issn.2095-3941.2023.0281.full.pdf
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Anemia from ADT treatment = T-inhibitors and/or AR inhibitors

Us Too Warriors,

If your anemia is too bad the Doctor may give Blood Transfusions. Mine is slightly low on AR= Casodex but because I am not on T-hibitor= Lupron, it is not too low. If your testosterone is low because of your age you may be anemic without these drugs. Anemia may be evidenced by shortness of breath and/or fatigue.
See Paper Below

Best
Peter

Abstract:

Objective. Haemoglobin levels often decline into the anaemic range with androgen deprivation therapy (ADT). We conducted a chart review of patients receiving ADT for metastatic prostate cancer to assess anaemia-related symptoms.

Methods. 135 stage IV prostate cancer cases were reviewed for treatment type; haemoglobin values before and after treatment; and symptoms of anaemia. Mean haemoglobin levels before and after for all treatment forms, for leuprolide alone, and for combination leuprolide/bicalutamide were calculated and evaluated for significant differences. The numbers of patients developing symptoms were recorded and the effects of specific therapies evaluated.

Results. For all ADT treated patients, mean haemoglobin declined by −1.11 g/dL (p < .0001). Leuprolide-alone treated patients had a mean decline of −1.66 g/dL (p < 0.0001). Leuprolide and bicalutamide combination treatment caused a mean decline of −0.78 g/dL (p = 0.0426). 16 of 43 patients had anemia symptoms. Contingency analysis with Fisher's exact test shows patients receiving leuprolide therapy alone versus other forms of ADT were significantly less likely to have symptoms (χ2 = 0.0190).

Conclusions: The present study confirms that ADT results in a significant drop in haemoglobin levels into the anaemic range. A number of patients become symptomatic from this change. Practitioners should monitor haemoglobin levels, and treat symptomatic patients.

Link 1 : "Anemia"
or Go To
https://www.tandfonline.com/doi/full/10.1080/13685530802172438
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Zero Cancer- Veteran's Brochure for Prostate cancer

Us Too Warriors,

Warriors, Veterans have a 1 in 5 chance of getting Prostate cancer - almost double the male population.

The high numbers may be from Chemical Exposures like agent Orange or Burn pits or the stress of military engagement or duty. But, make sure your military friends have regular Prostate cancer screenings.

See this website for the Brochure
Best
Peter

Link 1 : "Brochure"
or Go To
https://online.flippingbook.com/view/219351375/
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Study Shows How Morphine May Contribute to Bone Loss and Cancer-Induced Bone Pain and Death

Us Too Warriors,

Morphine is often used in Hospice for PCa which may hassen death but the attached article suggests it may not be good for pain. Jerry Dean was suffering with pain in hospice near the end. I do not know if he was on Morphine but it looks as if you would need to be knocked out with morphine not to feel the bone pain it would cause.
Best
Peter

Link 1 : "Morphine"
or Go To
https://theoncologynurse.com/issue-archive/2023/august-2023-vol-16-no-5/19635-study-shows-how-morphine-may-contribute-to-bone-loss-and-cancer-induced-bone-pain
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Zero Cancer- ADT educational Book/Program to make Lupron /AntiAndrogens work Better

Us Too Warriors,

Many of you know that I am not a fan of ADT because of the possible side effects to the Brain, Heart is muscle, body muscles and fatigue that damage the quality of life. But for some men it may extend life and if the man is disciplined enough he may be able to fight off the life destroying side effects but it is not easy!!! For example to prevent muscle loss you may need to take supplements like CoQ10 (200mg/d) besides exercise of = ~>30min/d which becomes very hard if you have fatigue from ADT. Go to this website below to learn more
Best
Peter

Link 1 : "Book/Program"
or Go To
https://www.lifeonadt.com/

Video explaining the use of high Dose Melatonin to stop Advanced PCa(& other cancers) Growth

Us Too Warriors,

I have used melatonin for many years to slow my cancer. (this may be important if you have advanced PCa.) I started with 20 mg per night and now I am at 40 mg now. But the video suggests a very high dose like 180 mg/night. Also, with my high number (10+) of CT, MRI and Pet scans radiation, the video suggests 300 mg before the scan to block radiation Damage. Some people(<10%?) have trouble with melatonin even at low doses <10mg,so try low doses before you try higher to see if you can handle it? I Plan to work my way up slowly to higher doses. It does not require a prescription and this site sells a 60mg pill if you are so inclined?

"www.scientifichealthsolutions.com"

A word of Caution, Melatonin is a blood thinner that can lead to excess bleeding if you have stomach bleeds or hemorrhoids. Aspirin, Aleve ( Nsaids) cause stomach bleeds especially with alcohol use. I use high dose (mega)Vitamin K2 (MK4) from Lef.org for stopping bleeding and getting calcium (hardening of my arteries) out of my arteries from Vitamin D higher adsorption of calcium. Blood thinning is one of the 8 ways claimed in the Video to slow cancer growth with melatonin.

Best
Peter

Dr. Frank Shallenberger, the president of the American Ozone Therapy Association, will demonstrate the crucial role of oxidative therapies in the maintenance and enhancement of mitochondrial energy production, an absolute necessity for better health and optimal aging.

Link 1 : "Optimizing Oxidation in the Care of Chronically Ill Patients"
or Go To
https://www.youtube.com/watch?feature=youtu.be&v=Roh4lQXneQg&fbclid=IwAR36FZEUynwOGS7C9-6unwT9RWr-XohL4fqylMAgUV2fzvMyN3dN7Oxsfgo&app=desktop

SBRT added to Abiratrone after Biochemical recurrence mets is a strong benefit over Abiraterone alone

Us Too Warriors,

Consider adding SBRT treatment when you can to metastasis treatment when possible see website to follow.
Best
Peter

The addition of SBRT to upfront abiraterone acetate and prednisone (AAP) reduced the risk of disease progression or death by 65% compared with AAP alone in patients with oligometastatic castration-resistant prostate cancer.

Link 1 : "SBRT"
or Go To
https://www.urologytimes.com/view/adding-sbrt-to-frontline-abiraterone-shows-benefit-in-oligometastatic-mcrpc?utm_source=sfmc&utm_medium=email&utm_campaign=09262023_UT_PHO-23-URD0421_Monthly%20eNL&eKey=cGNtb29uQHZjdS5lZHU=

Paper on use of Hi Dose Vitamin C Infusion to Fight cancers

Us Too Warriors,

Vitamin C IV at high doses produces Hydrogen peroxide that can kill cancer and may stop Mets. I have been using it as much as 4 times a week in the early summer at Up to 100 gms per dose and now I am at 125 gms twice a week. It can be used by itself or with other standard treatments. It costs about $250/100gm not covered by insurance. It works well with chemoTherapy. I am using it with my Immunotherapy which is new so no clinic data is available for it. But In general it may be needed and work best when the cancer is more advanced and you are dealing with CRPCa which does not have any good long lasting treatments yet or Metastases or hospice care. It may extend life or reduce side effects of pain, fatigue and upset from the meds that may occur with advanced cancers. Go to the website below for discussion on the use of IV Vitamin C with cancers.

Best
Peter

Link 1 : "Hi Dose Vitamin C"
or Go To
https://jeccr.biomedcentral.com/articles/10.1186/s13046-021-02134-y

FDA approved an over the counter cream for ED works for65% of men w/ED -no Prescription needed

Us Too Warriors,

Men with erectile dysfunction will now have the option of using a topical gel to treat the condition.

The U.S. Food and Drug Administration has approved over-the-counter marketing for the product, called Eroxon, as a first-of-its-kind medical product. The British pharmaceutical firm Futura Medical makes the gel.

"FDA set a very high standard in evaluating the effectiveness and safety of De Novo Medical Devices. I am delighted that we met this standard," Futura CEO James Barder said in a news release on Monday.

About 30 million American men are affected by erectile dysfunction, where they're not able to get or keep an erection for sexual activity.

This new gel will be sold in a single-dose tube, CNN reported.

It should be applied to the head of the penis before sex. Users may be able to become erect within 10 minutes and maintain that for long enough to have sex in about 65% of those who use it, according to the company.

The product is already sold in Belgium and the United Kingdom, where it costs the equivalent of $31.22 in U.S. dollars for a four-pack, CNN reported.

"We don't have specific pricing details yet, as the pricing will ultimately be determined by the partner who launches Eroxon in the U.S.," a company spokesman told CNN.

The timeline for when the product will be in the United States is unknown but it could be 2025, CNN reported.

Diseases such as Type 2 diabetes can contribute to erectile dysfunction, as can certain medications, anxiety disorders, smoking, drinking excessive alcohol, being overweight.

Best
Peter

To See More Info - Click on the Link Below:

Link 1 : "ED"
or Go To
https://www.niddk.nih.gov/health-information/urologic-diseases/erectile-dysfunction/symptoms-causes

Prescription Vitamin D = 1,25 OH Vitamin D is "Active" in the body and need not go thru liver and kidneys

Us Too Warriors,

Over the Counter 25 OH Vitamin D3, you can buy at drug stores without a prescription and it is not active in the body to change/produce genes functioning until it is processed in your liver and kidneys.. I will be discussing these vitamin Ds tomorrow at the meeting.

I started taking Active 1,25 OH Vitamin D before about 2010 after reading a clinical article by a Dr. DeBeer in Washington State printed in 2008. He had a small group of 8 men with PCa which gave a low dose 0.5 mcg/d pill per day. 7 of the 8 had a drop in their PSA, and I got my VCU doctor to prescribe it for me at the time and ever since I along with that take a good dose of Vitamin K2 to keep calcium out (from all forms of Vitamin D3 Prescription and over the counter) of my veins. I also check my blood level of calcium for every blood test and avoid dairy to keep calcium levels lower.

These precautions are extremely important for both prescription and over the counter vitamin D. Calcium in veins hurts the heart and blocks blood flow especially In the carotid artery to the brain. My carotid arteries are 16% and 49% blocked. If it gets above 70% the doctors do surgery to unblock them. More at the meeting tomorrow

See paper below see the value of vitamin D. Its improvement of my immune system may be a reason I am defeating melanoma,

Best
Peter

Abstract:
Epidemiological studies indicate that vitamin D insufficiency could have an etiological role in prostate cancer. In addition, calcitriol, used in combination with currently available drugs, has the potential to potentiate their anticancer effects or act synergistically by inhibiting distinct mechanisms involved in prostate cancer growth. Clinical data have not yet provided sufficient evidence to demonstrate benefit of vitamin D due to the limited and underpowered studies that have been published to date. Here, we review the preclinical and clinical studies that describe the activity of calcitriol, applied either alone or in combination and assessed the mechanistic basis of pharmacodynamic and pharmacokinetic interactions with calcitriol. Important considerations for calcitriol use in combination therapy with respect to safety and clinical outcomes have been discussed. Many of these combinations have therapeutic potential for the treatment of several cancer types and it is anticipated that future clinical research will put emphasis on well‑designed clinical trials to establish efficacy.

To See the Info - Click on the Link Below:

Link 1 : "Vit D"
or Go To
https://pubmed.ncbi.nlm.nih.gov/26918053/#:~:text=Epidemiological%20studies%20indicate%20that%20vitamin%20D%20insufficiency%20could,inhibiting%20distinct%20mechanisms%20involved%20in%20prostate%20cancer%20growth.

SBRT radiation looks Promising primary treating gleason 3+4 prostate and Prostate mets

Us Too Warriors,

I had 3 rounds of SBRT treatment to treat my 10 melanoma metastases at different times. To optimize the radiation effectiveness, I started immunotherapy 3 to 5 weeks after SBRT and I did Vitamin C iv infusions right after SBRT ( these decisions were based on research papers). See attached information to follow for PCa. Best Peter

PS. My Melanoma is in remission as none of the mets are lighting up on FDG Pet scan. AMEN!!!
I walked a mile and a half today- the first time since Jan 25 th when I fell after my mile 1 1/2 walk at the end in my driveway and could not wall again until after brain surgery Feb 7th and rehabilitation to the end of March. Life is Good what blessing,
Best
Peter

To Read the Article - Click on the Link Below:

Link 1 : "SBRT"
or Go To
http://rvaprostatecancersupport.org/PDF/5 8 23 SBRT.pdf

********************************
Melatonin to aid Immune system in fighting cancers

Us Too Warriors,

I have been using Melatonin at about 30mg/night for years for sleep. Sleep I think helps the immune system. Melatoin aids the immune system. Papers attached suggested it fights many cancers including Breast. With my use of immunotherapy it should be a bonus.
Best
Peter

To Read the Articles - Click on the Link Below:

*

Boosting immune system against cancer by melatonin: A mechanistic viewpoint

Link 1 : "Link 1"
or Go To
https://pubmed.ncbi.nlm.nih.gov/31629760/

Antitumor effect of melatonin on breast cancer in experimental models: A systematic review

Link 2: "Link 2"
or Go To
https://pubmed.ncbi.nlm.nih.gov/36403922/#:~:text=The%20aim%20of%20this%20systematic%20review%20was%20to,Web%20of%20Science%2C%20and%20Embase%20databases%20were%20used.

*************************************************************************
Us Too Warriors,

RVA Us Too- MY useof IV vitamin C 75gm twice aweek decreased PSA30% when it should have goneup 50%. I am using it to fightmyStage four Melanoma

Melanoma,Grows the same as PCa accelerated by high androgen receptors.See attached paper -I have stage four melanoma with 10 mets 4 in legs , 3in Backbone and 2 in Brain. One in pelvis. I am having 3 radiation sessions to 8 of them, I have had brain surgery and Brain radiation. I can now walk slowly after 12 days of hospital rehab.

I am Thankful FOR for Prostate Cancer as my scan search for PCa mets found the large melanoma met I have in my pelvis. Androgen blockers for PCa fight melanoma and may keep my immunotherapy for melanoma Working.
See paper Below.
BestPeter

To Read the Studies - Click on the Links Below:

Link 1 : "Vit C 1"
or Go To
https://pubmed.ncbi.nlm.nih.gov/12837460/

Link 2 : "Vit C 2"
or Go To
https://www.findinggeniuspodcast.com/podcasts/promiscuous-molecules-jeanne-drisko-explains-the-vitamin-c-for-cancer-connection/

Rva Us Too- Last year in an email I talk how Nicolosamide lowered my PSA in PCa in heated&shaked in olive oil now - papers show it works for melanoma TOO!!!!!
Link 3 : "Nicolosamide 1"
or Go To
https://pubmed.ncbi.nlm.nih.gov/31465777/

Link 4 : "Nicolosamide 2"
or Go To
https://link.springer.com/article/10.1007/s11094-016-1471-5

**************************************************************
Improvement by PROTACs use could improve androgen receptor blocking Therapy in treating PCa and Melanoma Cancers

Us Too Warriors,

If this treatment becomes available it will overcome Androgen receptor blocking failure like my Brother has experienced with Xtandi and I have experienced from Casodex.

And Jerry Deans experienced failures that eventually lead to his Death. See attached Links
Best
Peter

To Read More - Click on the Link Below:

Link 1 : "Improvement 1"
or Go To
https://pubmed.ncbi.nlm.nih.gov/30271980/
*
Link 2 : "Improvement 2"
or Go To
https://www.biorxiv.org/content/10.1101/2022.05.27.493720v1

More information about an imunnotherapy for PCa from a Member who benefited for clinical trial

Us Too Warriors,

This is from a member of our group==>"For prostate cancer patients, keep Enoblituzumab on your radar screen. I participated in a clinical trial at Johns Hopkins, Sidney Kimmel cancer center, and received this immunotherapy agent prior to surgery and was one of 7 patients that had the desired response. Sometime later, I heard of a patient who had had his prostate removed, he had an undetectable PSA, but it had metastasized. He read about the study I participated in and approached Johns Hopkins. They constructed an N-1 study for adjuvant treatment for him and at the time of the article, which was published by Johns Hopkins, he was undetectable, and the metastases had all but disappeared.
Best
Peter

To Read More - Click on the Link Below:

Link 1 : "(Imunnotherapy)"
or Go To
https://www.onclive.com/view/early-data-make-b7-h3-a-checkpoint-contender-in-prostate-cancer-and-beyond

Treatment from a Blog on Mets to spine causing Pain and possible treatment

Us Too Warriors,

I have just completed SBRT treatment to 3 spine Vertebrae, I have no pain yet but to be proactive I have found and ordered an enzyme to prevent pain. I know Jerry Dean suffered Bad pain in his back near the end. Blog below describes this treatment. It is called "Serrapeptase" available w/o prescription on Amazon.
Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "Pain"
or Go To
http://rvaprostatecancersupport.org/PDF/1 14 23 Mets to the spine.pdf

Bone health is important for PCa and also for the Brain Function with age

Us Too Warriors,

Years ago I first reported on a startling discovery – one of the most important factors that keeps your brain healthy and your memory intact is a hormone released by your bones.

And unless you can support your bones in their task of supplying the brain with this vitally important natural chemical called osteocalcin, your memory will almost certainly fracture.

Even though the studies of osteocalcin haven’t been as widely reported as they should have been, researchers have been proceeding full throttle to better understand how this hormone influences the health of your brain and other organs.

Medical folks once believed that your bones mostly function as a structural support system for your body, kind of like beams in a house. However, a new investigation into hormones released by bone tissue have them rethinking that view.

And some of the most surprising findings have centered on how osteocalcin released by the bones affects the brain.
Best
Peter

Necessary for Brain Function

As researchers at Columbia University have noted, their lab tests on animals reveal “a remarkable, totally unexpected aspect of the bone-derived hormone osteocalcin is that it is necessary for both brain development and brain function.”1

To Read the Info - Click on the Link Below:

Link 1 : "(Brain Function)"
or Go To
https://awakeningfromalzheimers.com/want-a-healthy-brain-look-to-your-bones/
**
Immunotherapy is starting to make a splash in treatng Prostates cancer (PCa)

Us Too Warriors,

It looks as if Immunotherapy is starting to Impact on PCa. Look up papers below for more informations - These are the first I have seen.

I expect to have speaker in the near future if covid sub sides to speak about his great results from a clincal trial with Nivolamab immunotherapy. I am getting this therapy soon for my melanoma and hope it helps my PCa.

Usually prostate cancer is considered a "cold" cancer that does not lightup the immune system but if you have the right mutations it seems to work well.
Best
Peter

Abstract

Background:
CheckMate 9KD (NCT03338790) is a non-randomized, multicohort, phase 2 trial of nivolumab plus other anticancer treatments for metastatic castration-resistant prostate cancer (mCRPC). We report results from cohorts A1 and A2 of CheckMate 9KD, specifically evaluating nivolumab plus rucaparib.

To Read the Info - Click on the Link Below:

Link 1 : "(Immunotherapy 1)"
or Go To
https://pubmed.ncbi.nlm.nih.gov/35977756/
*
Abstract

Background:
Docetaxel has immunostimulatory effects that may promote an immunoresponsive prostate tumour microenvironment, providing a rationale for combination with nivolumab (programmed death-1 inhibitor) for metastatic castration-resistant prostate cancer (mCRPC).

Link 2 : "(Immunotherapy 2)"
or Go To
https://pubmed.ncbi.nlm.nih.gov/34802864/
**************************************
Drinking enough water to lower sodium below the Middle range of normal range, but not below normal to add years to your Life

Us Too Warriors,

The importance of drinking enough water was recently Printed online to dilute your Sodium level so you live longer See below Middle-age high normal serum sodium as a risk factor for accelerated biological aging, chronic diseases, and premature mortality
Open Acces - Published:January 02, 2023 - DOI:https://doi.org/10.1016/j.ebiom.2022.104404
Best
Peter

Summary

Background

It is known that some people age faster than others, some people live into old age disease-free, while others develop age-related chronic diseases. With a rapidly aging population and an emerging chronic diseases epidemic, finding mechanisms and implementing preventive measures that could slow down the aging process has become a new challenge for biomedical research and public health. In mice, lifelong water restriction shortens the lifespan and promotes degenerative changes. Here, we test the hypothesis that optimal hydration may slow down the aging process in humans.

To Read the Info - Click on the Link Below:

Link 1 : "(Drinking Enough Water)"
or Go To
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00586-2/fulltext

Website with some Free courses that may help you fight your cancer

Us Too Warriors,

Look at the courses available at this website to see if they float your boat. I will be taking a course onImmunology from Rice University for free.

Best
Peter

Fundamentals of Immunology Specialization

Learn basic concepts and vocabulary in immunology!. Analyze new developments in immunological therapies designed for the treatment of disease.

To Read the Info - Click on the Link Below:

Link 1 : "(Free Courses)"
or Go To
https://www.coursera.org/specializations/immunology?recoOrder=0&sfmc_id=110714670&sfmc_key=0038W00001l2EfSQAU

A new tool in my bag to Fight Prostate and Melanoma - Combination of " IV Vitamin C, Doxycycline and Niclosamide"

Us Too Warriors,

With only High IV Dose Vitamin C use (~50 grams at least twice a week), analysis of PCa treatment shows that it does not lower PSA but that it increases the doubling time which can add more days to your life which I hope to do as my doubling time over the 2 I/2 years usually has been between 3 to 5 months except for a 4 month period when niclosamide stopped it from doubling and dropped it 10%. My present plan is to add IV vitamin C and Niclosamide to my immunotherapy and in future to consider adding Doxycycline which I had used for years but recently stopped because of concern it might affect my gut biome bacteria so as to make my immune system less strong. I will reconsider the use of doxycycline after I see how the Immunotherapy is working???

The paper attached below discusses how this off label use of these drugs can reduce cancer growth by attacking Cancer stem cells.

Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "Combination"
or Go To
https://pubmed.ncbi.nlm.nih.gov/28978032/

*
Radiation for Bone Metastases May Improve Cancer Survival- This is why I am having SBRT w/ Dr Cuttino at Henrico Dr. Hospital Forest

Us Too Warriors,

You may want to file this website below away in case your cancer produces bone Metastasis. My prostate cancer did but I seem to beat it with all I do and Casodex over the last 5 years. But In the last Six months the Melanoma has come on with a vengeance to produce 7 bone mets spots. Bone mets in melanoma are much more unusual compared with Prostate cancer. Bone mets only occur in 4% of the people with melanoma so there is not a lot of research on their treatment.
I think this website to follow is good as it gets in supporting radiation treatment for bone mets.

Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "Link"
or Go To
https://www.medpagetoday.com/meetingcoverage/astro/101436?xid=nl_mpt_SR_specialty_update_2022-11-11&eun=g2139714d0r

*
Secondary cancers associated with Prostate cancer

Us Too Warriors,

This is designed to give you warning that there have been some cancers found to be associated with prostate cancer. I have seen that in my case Melanoma may occur at 20% rate in conjunction with prostate cancer . But,I am particularly vulnerable because I have a red hair gene that makes it 8x times more likely. This web site to follow gives other cancers to be vigilant to detect along with your Prostate cancer. In fact, I found my melanoma Metastasis when searching with a pet scan for prostate cancer metastasis progression.

Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "Link"
or Go To
https://www.cancer.org/cancer/prostate-cancer/after-treatment/second-cancers.html

*
Blog on Discusson of Leakage after PCa surgery and years later

Us Too Warriors,

If you are dealing with incontinence the website below may help. It seems normal to have some stress incontinence that may be made worse by excess water and alcohol, etc.

Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "Blog"
or Go To
https://www.inspire.com/groups/zero-prostate-cancer/discussion/incontinence-long-after-prostatectomy/?dderh=218d4627157bf6a9995654341fd4764d

*
Blog on pain management in men with Advanced Prostate cancer

Us Too Warriors,

I have copied below the response of men dealing with Pain management in advanced Prostate cancer. This is a concern if cancer progresses. SBRT radiation can help and there are many avenues of drug & supplement treatment. It is important to find what works for you without causing other problems.

Nsaids can be a problem if used long or high doses. It help kill my wife after 32 years of Pain. CBD oil and marijuana can help and are being recognized as beneficial. For Now CBD oil and heating pad and movement are adequate for me. I hope what follows will help you manage if you have need. Have A blessed Christmas and New Year.

Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "Blog"
or Go To
http://rvaprostatecancersupport.org/PDF/12 13 22 pain management.pdf

*
Jane McLellan Storey-How She Starve her cancer & My story fighting Prostate cancer w/off label Drugs, Supplemeents & diet is simular

Us Too Warriors,

See the website to find out more that follows and I too depended on Life Extension magazine(Free) for new ammunition besides google research articles to fuel my PCa treatment (28 years). I use some of the same off label drugs (doxycycline and metformin etc). I am now doing the same to fight my Stage 4 melanoma. I will be using high dose IV Vitamin C as She has if I qualify after my blood tests this week. Look at the website below to get the flavor of this Process All the best for for your fight and the holidays

Best
Peter

Against All Odds

Jane McLelland beat cervical, lung, and blood cancers using the missing link to defeat cancer: starving it. She is partnering with Life Extension® to help other patients achieve the same results.

Scientifically reviewed by Dr. Gary Gonzalez, MD, in May 2022. Written by: Laurie Mathena.

Link 1 : "Website"
or Go To
https://www.lifeextension.com/magazine/2020/1/wellness-profile

*
Bone cement to strenghten Bone Mets - I wll be seeing an orthopedist at VCU to see if this would strengthen backbone & Hip mets

Us Too Warriors,

In my 28 years fighting cancer, I had not heard of the use of Bone cement used for treatment prostate cancer but when I contacted a VCU doctor to review my body scans of melanoma he referred me to an Orthopedist doctor in January for bone cement treatment to my mets. After I see him I will report what I find. For now I have attached a paper with some information to use. It appears bone cement can be used in three ways.- 1. as a strengthening of the weakened bone from metastasis or 2. as source medication to kill the cancer in the bone or 3. for both purposes.

Abstract

Metastatic bone lesions are common among patients with advanced cancers. While chemotherapy and radiotherapy may be prescribed immediately after diagnosis, the majority of severe metastatic bone lesions are treated by reconstructive surgery, which, in some cases, is followed by postoperative radiotherapy or chemotherapy. However, despite recent advancements in orthopedic surgery, patients undergoing reconstruction still have the risk of developing severe complications such as tumor recurrence and reconstruction failure. This has led to the introduction and evaluation of poly (methyl methacrylate) and inorganic bone cements as local carriers for chemotherapeutic drugs (usually, antineoplastic drugs (ANPDs)). The present work is a critical review of the literature on the potential use of these cements in orthopedic oncology. While several studies have demonstrated the benefits of providing high local drug concentrations while minimizing systemic side effects, only six studies have been conducted to assess the local toxic effect of these drug-loaded cements and they all reported negative effects on healthy bone structure. These findings do not close the door on chemotherapeutic bone cements; rather, they should assist in materials selection when designing future materials for the treatment of metastatic bone disease.

Link 1 : "Website"
or Go To
https://pubmed.ncbi.nlm.nih.gov/33552885/

*
Portos Decipher TEST of 24 Genes shows men who benefit from Increased radiation Dose after BioChemical recurrrence after surgery

Us Too Warriors,

Check this website to find out more below.

Hope you had Healthy Thanksgiving

An analysis from the phase 3 SAKK 09/10 trial presented at the 2022 ASTRO Annual Meeting showed that PORTOS, an expression signature of 24 DNA damage repair and immune pathway genes, has the potential to predict which patients will benefit from dose-intensified salvage radiotherapy (SRT) after radical prostatectomy.1,2

Link 1 : "Website"
or Go To
https://www.urologytimes.com/view/molecular-signature-predicts-response-to-dose-intensified-salvage-radiotherapy-after-rp

***********************************************
Flash lower dose Proton beam treatment trial for Bone Pain from PCa Metastasis- Promising

Us Too Warriors,

Bone Pain is a big down side of PCa Metastasis which I saw Jerry Dean suffer so any improvement in its treatment is a blessing for people with cancer. This proton beam treatment looks to help. I am not sure how much better it is for pain then SBRT radiation - like the Gamma Knife but it is only the clinical stage now so we will need more information.

Bone Metastases Treated in a FLASH: One Dose of Proton RT

These patients had up to three painful bone metastases in their extremities, but no lesions in the hands, feet, or wrists. They were also required to have a life expectancy of more than 2 months.

There were five male and five female participants, and the median age was 63 years. All of the patients were white, non-Hispanic, and they had a range of primary histologies, including lung, breast, prostate, and thyroid cancer, and multiple myeloma.

Link 1 : "Bone Pain"
or Go To
https://www.medscape.com/viewarticle/982952?src=mkm_ret_221113_mscpmrk_BC_monthly&uac=318354AK&impID=4853207#vp_2

*********************************************
Filtering blood to remove Circulating Tumor Cell is Being developed to prevent Metastasis with CRPC and other cancers

Us Too Warriors,

The future may allow filtering of blood to treat many cancers including prostate cancer- early study looks promising. See the following website !!!

Link 1 : "Filtering Blood"
or Go To
https://extheramedical.com/extracorporeal-blood-filter-removes-circulating-tumor-cells-dialysis-like-cell-removal-therapy-to-be-studied-for-treating-metastatic-cancer/

*
My fellow Members it looks as if I am in for rought ride with Likely neuroendocrine prostate cancer

Us Too Warriors,

I have attached a paper to give you a flavor of this form of prostate cancer that will occur in 15 to 20% of men that become Hormone refractory if they are on ADT for long periods of time. I have been treating PCa for 28 years as of NOV 15th,1994 so I qualify as a long time treater but only on ADT for ~5 years.

I am attaching a paper below which will give you a flavor of what you have to figure out as of now of how to pick possible treatments. This is not a very straight or clear path. I hope I will know more for our next meeting at 2 PM on Nov 17 th. I hope as I travel down this path I can learn ways to help others that follow this path after me.Best Peter

Abstract

Lineage plasticity and histologic transformation to small cell neuroendocrine prostate cancer (NEPC) is an increasingly recognized mechanism of treatment resistance in advanced prostate cancer. This is associated with aggressive clinical features and poor prognosis. Recent work has identified genomic, epigenomic, and transcriptome changes that distinguish NEPC from prostate adenocarcinoma, pointing to new mechanisms and therapeutic targets. Treatment-related NEPC arises clonally from prostate adenocarcinoma during the course of disease progression, retaining early genomic events and acquiring new molecular features that lead to tumor proliferation independent of androgen receptor activity, and ultimately demonstrating a lineage switch from a luminal prostate cancer phenotype to a small cell neuroendocrine carcinoma. Identifying the subset of prostate tumors most vulnerable to lineage plasticity and developing strategies for earlier detection and intervention for patients with NEPC may ultimately improve prognosis. Clinical trials focused on drug targeting of the lineage plasticity process and/or NEPC will require careful patient selection. Here, we review emerging targets and discuss biomarker considerations that may be informative for the design of future clinical studies.

To go to the Article - Click on the Link Below:

Link 1 : "Therapy Considerations"
or Go To
https://pubmed.ncbi.nlm.nih.gov/34111024/

*
Cancer - Table of the two names for each prostate cancer drug

Us Too Warriors,

The below table may be useful.

Best Peter

*
Photo Dynamic Therapy (PDT) in place of Active surveillance for low threat cancers-Available in Europe and Mexico- USA soon???

Us Too Warriors,

PDT looks promising in reducing progression that can occur during active surveillance. See the following Article for details.

Best Peter

To go to the Article - Click on the Link Below:

Link 1 : "Photo Dynamic Therapy"
or Go To
http://rvaprostatecancersupport.org/PDF/10 31 22 PHOTODYNAMIC THERAPY.pdf

*
Dr Bulsic (NIH/speaker at meetings in 2018-2019) found Metformin lowers PSA in 40% of men with T2Diabetes

Us Too Warriors,

I have taken 1500 mg/d of metformin for several years to fight my PCa. If you take metformin you should also take CoQ10 to keep you muscles from hurting as metformin tends to reduce this in your muscles that can make them painful. I do not have diabetes but I think it helps limit my blood sugar to about 80 to 90 Glucose Units (?). You want your glucose to be less than 100 but if it goes below 70 it can cause one to black out.

Best Peter

To go to the Article - Click on the Link Below:

Link 1 : "Article"
or Go To
https://pubmed.ncbi.nlm.nih.gov/33562646/
*
Lupron is not only Bad for your health compared to the Oryvix pill - It is way more expensive at $38,000 per shot

Us Too Warriors,

If you are getting Lupron shots to block your testosterone, you should switch to ORYVIX pills which are not bad for your heart as lupron is!!! By my not going on Lupron in the year 2000 when I had biochemical recurrence of my cancer I have saved the government $1,500,000 and myself $$$$ and 44 shots. Also, a recent ultrasound heart test in the hospital showed no blockage of heart arteries! See the website below for more information.

Best Peter

To go to the Website - Click on the Link Below:

Link 1 : "Lupron Shot vs Oryvix Pill"
or Go To
https://www.npr.org/sections/health-shots/2022/10/26/1131130875/it-cost-38-398-for-a-single-shot-of-a-very-old-cancer-drug
*
How fat contributes to Prostate cancer growth.

Us Too Warriors,

I accompanied my Brother to See Dr Meyers in C'ville, Va about 2014 after many years trying to get him to stop eating bacon to no avail.

AS we were finishing the visit I told on his eating of bacon. Dr. Meyers was very nice about how he replied that he grew up in Pennsylvania Ducth country and ate all the pig stuff growing up. To which my brother replied isn't pork the other white meat? ! Doctor Meyers' answer was "NO" (you have to be careful about how you fall for food advertisements). See the Website below -About Fat like Bacon or chicken fat and skin.

Best Peter

To Read More - Click on the Links Below:

Link 1 : "Fat"
or Go To
https://news.weill.cornell.edu/news/2019/11/high-fat-diet-contributes-to-prostate-cancer-progression#:~:text=%E2%80%9CA%20high%2Dfat%20diet%20causes,cancer%20lethality%2C%E2%80%9D%20said%20Dr
***************************************
One of our members, Chris, had 50% drop in his PSA from1 1.4 to 0.7ng/ml using 3 supplements

Us Too Warriors,

The 3 supplements were Capsaicin, CBD oil and Curcumin. Below you will find some papers supporting these supplements for a slowing of PSA.

I am ordering Capsaicin today called "Cayenne "by Nature's Way from Swanson, I have some CBD oil my wife used for her Fibromyalgia pain and I have ordered more from Swanson. I have been taking Super Bio Curcumin for at least 17 years from Life extension and I am going to increase my 5 pills a day of life extensions 10 + pills, I used to take 15 a day. Now, my PSA is rising, I will be trying these agents to slow its rise. You may want to consider it too if your PSA is rising.

Best Peter

To Read More - Click on the Links Below:

Link 1 : "Capsaicin"
or Go To
https://pubmed.ncbi.nlm.nih.gov/20174488/
*
Link 2 : "Non-THC cannabinoids inhibit prostate carcinoma growth"
or Go To
https://pubmed.ncbi.nlm.nih.gov/22594963/

Link 3 : "Curcumin against Prostate Cancer: Current Evidence "
or Go To
https://pubmed.ncbi.nlm.nih.gov/33182828/
***************************************
Us Too Warriors,
All cardiac Deaths on ADT (Lupron) was 4.78X higher than men with PCa of age 70 to 79 website Link Below"

Us Too Warriors,
This is another reason I have been avoiding Lupton etc for 28 years, If you are on Lupron you need to have a cardiologist do everything to protect your heart. Remember your heart is a muscle and Lupron among its many faults is it causes muscle loss and also the weight gain that it induces is hard on the heart. Exercise is harder to do from fatigue but it is one of the few actions that helps

Best
Peter

FRIDAY, July 29, 2022 (HealthDay News) -- For patients with prostate cancer, use of androgen-deprivation therapy (ADT) is associated with an increased risk for cardiovascular disease (CVD) death, according to a study published online July 26 in The Aging Male.

Justinas Jonusas, from the National Cancer Institute in Vilnius, Lithuania, and colleagues examined the risk for CVD mortality in a retrospective cohort study of patients aged 40 to 79 years diagnosed with prostate cancer between Jan. 1, 2012, and Dec. 31, 2016. The final cohort included 13,343 prostate cancer patients who exclusively used gonadotropin-releasing hormone agonists.

To read more Go to the Website - Click on the Link Below:

Link 1 : "Website"
or Go To
https://www.practiceupdate.com/news/38817/3/3?elsca1=emc_enews_top-10&elsca2=email&elsca3=practiceupdate_uro&elsca4=urology&elsca5=newsletter&rid=NTU2MjE4MTA4NzMS1&lid=20845145

*
Us Too Warriors,
A Study - SBRT for bone metastases in oligometastatic patients

Us Too Warriors,
Consider SBRT as a way to avoid Androgen deprivation Therapy if Mets show up in a Bone scan.

I signed up for a PET bone scan at Henrico Doctors hospital on Sept 12th to see if my mets have changed from a 4+ years ago from my AXumin Scan.

Dr. Cuttino, who spoke at Our meeting a few years ago, is at Sarah Cannon Cancer Building at Henrico Doctors at Forest and Does SBRT treatment
(Jerry Deans benefited from her treatment for a while). I would have her treat me if it looks appropriate.

Best
Peter

To Read the Study Info - Click on the Link Below:

Link 1 : "SBRT"
or Go To
http://rvaprostatecancersupport.org/PDF/8 29 22 Phase 1 .pdf

*
Us Too Warriors,
Cryo-Immuno Focal Clinical trial Reported in the Latest issue of Life Extension magazine website - now recruiting

Us Too Warriors,

This is a new way of attacking PCa with mets. The trial is recruiting See Belolw
Best
Peter

Cancer Therapy & Clinical-Trial Opportunity

A clinical trial uses a new combination of cryo-immune focal therapies against various types of cancer. The goal is to achieve optimal patient outcomes while avoiding serious side effects.
By William Faloon & Stephen Strum, M.D..

To go to the Website - Use the link below:

Link 1 : "'Cryo-Immuno'"
or Go To
https://www.lifeextension.com/magazine/2022/9/cancer-therapy-clinical-trial?sourcecode=CVH220E&CID=710901d4-5914-4258-8b0b-f4b4f1a219b7
******
Us Too Warriors,
Paper attached that outlines how I can approach treat of my mCRPC with ARV-7 splice testosterone positive Cancer

Us Too Warriors,

The paper below is the best information I have been able to garner to give a path on treatments for my particular Flavor of mCRPC cancer. This cancer flavor occurs on Xtandi, Zytiga or Bicalutamide or " ....lutamides" when they stop working for 30%+ of men on these failed treatments.

My Bicalutamide (Casdex) worked excellently for 2 1/2 years before it failed and PSA started back up after dropping 99%. I have not been able to get the ARV-7 test because it is not FDA approved for Casodex even though ARV-7 was first found in men treated and failed with Casodex. I know I am ARV-7 because my PSA stopped doubling on Niclosamide and went down 10%. This is a crazy medical world we live and die in.

If you have mCRPC see the paper below or are being treated by ".....Lutamides or Zytiga" which are expected to fail in 3 to 6 years.
Best
Peter

Abstract:

Metastatic prostate cancer is the most common cancer in males and the fifth cause of cancer mortality worldwide. Despite the major progress in this field, leading to the approval of novel anti-androgens, the prognosis is still poor. A significant number of patients acquire an androgen receptor splice variant 7 (AR-V7), which is constitutively activated and lacks the ligand-binding domain (LBD) while maintaining the nuclear localization signal and DNA-binding domain (DBD). This conformational change, even in the absence of the ligand, allows its retention within the nucleus, where it acts as a transcription factor repressing crucial tumor suppressor genes. AR-V7 is an important oncogenic driver and plays a role as an early diagnostic and prognostic marker, as well as a therapeutic target for antagonists such as niclosamide and TAS3681. Anti-AR-V7 drugs have shown promise in recent clinical investigations on this subset of patients. This mini-review focuses on the relevance of AR-V7 in the clinical manifestations of castration-resistant prostate cancer (CRPC) and summarizes redemptive therapeutic strategies.

To Read the Paper - Use the link below:

Link 1 : "'Paper'"
or Go To
https://pubmed.ncbi.nlm.nih.gov/34073713/
*
Us Too Warriors,
losses in life from disease, aging, work and friends can lead to feelings of loneliness & depression

Us Too Warriors,

RVA Us Too Friends- Life throws us lemons and we need to make lemonade out of them. See below.
Best
Peter

To Read the Article - Use the link below:

Link 1 : "'Losses in Life'"
or Go To
https://www.medicalnewstoday.com/articles/314905
*
Us Too Warriors,
Cancer Patients need to add Zinc and Magnesium CITRATE to their cancer treatment!! search online for these supplements

Us Too Warriors,

Citrate supplements can slow Prostate cancer & OTHER CANCERS. The following argument is copied from the paper Attached below. Citric acid which I have as supplement powder (very sour). Also lemon and as Limes not orange juice( too much sugar) If you do not have enough citrate in your blood the cancer will make more energy in its cells to help it grow but if you add citrate to your blood cancer will make less to grow with.

"Similar results have been observed in prostate cancer7. In vitro, several studies8,9,10,11,12 found that citrate reduced proliferation in multiple tumor cell lines. Loss of citrate synthase led to dramatically upregulated glycolysis, decreased citrate production and accelerated tumor growth and metastases13.
Best
Peter

Abstract:

In this study we have tested the efficacy of citrate therapy in various cancer models. We found that citrate administration inhibited A549 lung cancer growth and additional benefit accrued in combination with cisplatin. Interestingly, citrate regressed Ras-driven lung tumors. Further studies indicated that citrate induced tumor cell differentiation. Additionally, citrate treated tumor samples showed significantly higher infiltrating T-cells and increased blood levels of numerous cytokines. Moreover, we found that citrate inhibited IGF-1R phosphorylation. In vitro studies suggested that citrate treatment inhibited AKT phosphorylation, activated PTEN and increased expression of p-eIF2a. We also found that p-eIF2a was decreased when PTEN was depleted. These data suggest that citrate acts on the IGF-1R-AKT-PTEN-eIF2a pathway. Additionally, metabolic profiling suggested that both glycolysis and the tricarboxylic acid cycle were suppressed in a similar manner in vitro in tumor cells and in vivo but only in tumor tissue. We reproduced many of these observations in an inducible Her2/Neu-driven breast cancer model and in syngeneic pancreatic tumor (Pan02) xenografts. Our data suggests that citrate can inhibit tumor growth in diverse tumor types and via multiple mechanisms. Dietary supplementation with citrate may be beneficial as a cancer therapy.

Link 1 : "'CITRATE'"
or Go To
https://pubmed.ncbi.nlm.nih.gov/28674429/
*
Us Too Warriors,
Longer Use of Avodart( Dutasteride)and Proscar (Finasteride) reduced death by more than 1/2 from PCa in long time Users

Us Too Warriors,

I am a long time user (>8yrs) at 23 years and counting. This is best started early like right after surgery or radiation in primary treatment before PSA is<1.0 . It worked for 14 years for me. It is worth talking to your Doctor about because they block Dihydrotestosterone which grows cancer 10X faster than testosterone,
Best
Peter

Association of 5α-Reductase Inhibitors With Prostate Cancer Mortality

Abstract:

Importance There is evidence that 5α-reductase inhibitors (5-ARIs), a standard treatment of benign prostate hyperplasia, are associated with a decrease in the incidence of prostate cancer (PCa). However, studies to date have had conflicting results regarding the association with prostate cancer mortality (PCM).
Link 1 : "'Longer Use'"
or Go To
https://jamanetwork.com/journals/jamaoncology/fullarticle/2792528?guestAccessKey=a3ba6b9f-891b-4fe7-b3e4-211616194312
*
Us Too Warriors,
Lactate, Lactose & Lactic Acid (in food) increases cancer growth especially as the cancer progresses

Us Too Warriors,

This increased cancer growth is evident at Biochemical cancer recurrence after primary treatment failure and when Metastasis has occurred on failure of primary treatment or on initial diagnoses (if diagnosis was not early enough to predate metastasis).

At these time points, Lactate and Lactic Acid are produced in the body from Sugar at these advanced cancer stages by what is called the "Warburg Effect". Acid pH builds up in the body's tissue around cancer mets that contribute to the deadly effects of metastases. It's best not to add to this acid effect by eating food with Lactose, lactate or lactic acid in it. Also, you need to curtail your sugar intake.

Attached below are papers discussing this problem and list of food to avoid or reduce. Drinking Milk that contains lactose (milk sugar) increases PCa diagnosis significantly see paper below.

I was a big milk drinker - gallon at a time along with ice cream and cheese - All the wrong diet for prostate cancer that had me diagnosed early at 54 years instead at the normal peak about 67 years.
See below paper with lactate/lactic acid foods to avoid especially if you have BCR & Mets as I do.
Best
Peter

Abstract
Herein, we use lessons learned in exercise physiology and metabolism to propose that augmented lactate production ('lactagenesis'), initiated by gene mutations, is the reason and purpose of the Warburg Effect and that dysregulated lactate metabolism and signaling are the key elements in carcinogenesis. Lactate-producing ('lactagenic') cancer cells are characterized by increased aerobic glycolysis and excessive lactate formation, a phenomenon described by Otto Warburg 93 years ago, which still remains unexplained. After a hiatus of several decades, interest in lactate as a player in cancer has been renewed.

Link 1 : "'lactagenesis'"
or Go To
https://pubmed.ncbi.nlm.nih.gov/27993896/

New study associates intake of dairy milk with greater risk of prostate cancer

Link 2 : "'New Study'"
or Go To
https://news.llu.edu/research/new-study-associates-intake-of-dairy-milk-with-greater-risk-of-prostate-cancer

25 Foods High in Lactic Acid

Link 3 : "'25 Foods'"
or Go To
https://futurescopes.com/health/food/59780/25-foods-high-lactic-acid

The Role of Lactate Metabolism in Prostate Cancer Progression and
Metastases Revealed by Dual-Agent Hyperpolarized 13C MRSI

Abstract:
This study applied a dual-agent, 13C-pyruvate and 13C-urea, hyperpolarized 13C magnetic resonance spectroscopic imaging (MRSI) and multi-parametric (mp) 1H magnetic resonance imaging (MRI) approach in the transgenic adenocarcinoma of mouse prostate (TRAMP) model to investigate changes in tumor perfusion and lactate metabolism during prostate cancer development, progression and metastases, and after lactate dehydrogenase-A (LDHA) knock-out. An increased Warburg effect, as measured by an elevated hyperpolarized (HP) Lactate/Pyruvate (Lac/Pyr) ratio, and associated Ldha expression and LDH activity were significantly higher in high- versus low-grade TRAMP tumors and normal prostates.

Link 4 : "'Metabolism'"
or Go To
https://www.mdpi.com/2072-6694/11/2/257
*
Us Too Warriors,
For What it is Worth

Us Too Warriors,

I (Peter) should not get fatigue from Lupron. Moreover, my having GG alleles also predicts my cancer will be less aggressive than if I had CC or GC alleles which is nice to read.
The gene analyzed is the IL6-174 (rs1800795) Gene. IL6 is an Inflammatory Cytokine that makes often makes all disease worse and worse when at high levels in the blood.

Best
Peter

Genetic predictors of fatigue in prostate cancer patients treated with androgen deprivation therapy: preliminary findings

Abstract
Background: Fatigue is a common and distressing side effect of androgen deprivation therapy (ADT) for prostate cancer. The goal of the current study was to examine the relationship between changes in fatigue following initiation of ADT and single nucleotide polymorphisms (SNPs) in three pro-inflammatory cytokine genes: interleukin-1 beta (IL1B), interleukin-6 (IL6), and tumor necrosis factor alpha (TNFA).

Link 1 : " For What it is Worth"
or Go To
https://pubmed.ncbi.nlm.nih.gov/22475653/

Us Too Warriors,
Car-T studies seem to be starting to control side effects & a New type of cancer cell for CRPC has been found

Us Too Warriors,

Active Surveillance Plus Enzalutamide Monotherapy (Xtandi)vs Active Surveillance Alone in Patients With Low-risk or Intermediate-risk Localized Prostate Cancer ==>46% less progression but 56% Fatigue on Xtandi monotherapy (no Lupron added). My brother had Fatigue on Xtandi w/Lupron. I have not had fatigue on Casodex monotherapy.

Best
Peter

Link 1 : "Car-T"
or Go To
https://ascopubs.org/doi/abs/10.1200/JCO.2022.40.6_suppl.091

Home Health News - Cornell Scientists Have Identified a New Incredibly Common Subtype of Prostate Cancer
Link 2 : "Subtype"
or Go To
https://scitechdaily.com/cornell-scientists-have-identified-a-new-incredibly-common-subtype-of-prostate-cancer/

Us Too Warriors,
Free online course from John Hopkins' Dr Kenneth Pienta on Prostate Cancer treatment- next session starting Aug.1 (3WKs Long)

Us Too Warriors,

You may remember Dr Pienta who spoke well at the 2017 to 2019 Va Beach Cancer Meetings that as many as 20 of our Members attended. Jerry Deans saw him for a period of time after that meeting and other Doctors at J.H. which is known for the advanced research in PCa and is the closest to Richmond that a number of our members are treated at with advanced cancer.

I plan to take this course which will be most likely be standard of Care treatment that I have not done since my surgery in 1994.

Related Courses

Johns Hopkins University Introduction to the Biology of Cancer 4.3

Johns Hopkins University Understanding Cancer Metastasis 5.0

Johns Hopkins University Cancer Biology

Best
Peter

Link 1 : "Online Courses"
or Go To
https://www.classcentral.com/course/prostate-cancer-8070

Us Too Warriors,
Interaction Vitamin D & p53 Wild(Protective) But P53 Mut(NOTProt)

Us Too Warriors,

Jerry Deans With his p53 Mutation keeps teaching us how to protect ourselves. If you read this to the last paper you will see why I try to eat Broccoli a couple times a week and watercress as often as I can find it.
Good info follows.

Best
Peter

1st site below Vitamin D Protective when P 53 wild type still active in cancer

Link 1 : "Wild"
or Go To
https://pubmed.ncbi.nlm.nih.gov/32918225/

2nd site below Vitamin D not protective when p53 mutated most likely by metastasis if not before??? ( can be germline (inherited) or somatic developed w/Cancer progression to metastasis)

Link 2 : "Not Protective"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882298/

Website for p53 mutation testing info follows

Link 3 : "Testing"
or Go To
https://medlineplus.gov/lab-tests/tp53-genetic-test/#:~:text=A%20TP53%20genetic%20test%20looks,stop%20the%20growth%20of%20tumors

Broccoli and Watercress to Restore p53 wild type Protection and Keep Vitamin D3 fighting PCa!!!

Link 4 : "Restore"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260992/

Revisiting the Role of p53 in Prostate Cancer

Link 5 : "Role"
or Go To
https://exonpublications.com/index.php/exon/article/view/318/632#:~:text=Inactivating%20mutations%20in%20TP53%20occur,p53%20as%20a%20transcription%20factor

Us Too Warriors,
Alzheimer’s Breakthrough: Genetic Link to Gut Disorders Confirmed

Us Too Warriors,

Summary: A new study reveals a genetic link between Alzheimer’s disease and several gut-related disorders. Researchers report Alzheimer’s patients and those with intestinal disorders have specific genes in common. The findings add to the evidence the gut-brain axis may play a role in the development of neurodegenerative disorders. Source: Edith Cowan University People with gut disorders may be at greater risk of developing Alzheimer’s Disease (AD).

Please see the attached website link for details.

Best
Peter

Genes, Gut Diseases and Cholesterol are all tied to Alzheimer's that can benefit from statins like Prostate cancer can also.

Link 1 : "Alzheimer’s disease"
or Go To
https://neurosciencenews.com/alzheimers-gut-genetics-21058/

Us Too Warriors,
Curcumin, Apigenin, Berberine, Jerry Deans used to help him slow his PCa for 23 years in his Good Fight

Us Too Warriors,

Jerry Battled PCa for 23 years and found from genetic analysis he was fighting the loss of P53 anticancer gene and the harm of MDM2 to this pathway. From Us Too email messages he learned Curcumin, Apigenin, and Berberine helped his battle. Jerry lived a spiritual active life to the fullest to the end. His Church life was strong and he was also active in "Richmond Hill '' Weekend Spiritual Group. He was Active in his personal interests to the end as this last year he had his 100th dive on the reefs off the tip of Florida and camping with his family in the last few months.

One of the problems with being on clinical trials is they expect you to stop natural cancer agents which has to be a concern as they are helping in the battle. When I was sick in the middle of January 2022 and my wife died, I stopped all my treatments for a month and my PSA went from decreasing slowly to doubling every 2 weeks. I went back on the supplements/drugs and the PSA stopped growing.

Now, if Jerry were here I would tell him to add Rutin and Ginseng to Curcumin, Apigenin, and Berberine to fight his cancer P53 protection failure.

Please see the attached research paper for details.

Best
Peter

Abstract:

The p53 tumor suppressor plays a major role in controlling the initiation and development of cancer by regulating cell cycle arrest, apoptosis, senescence, and DNA repair. The MDM2 oncogene is a major negative regulator of p53 that inhibits the activity of p53 and reduces its protein stability. MDM2, p53, and the p53-MDM2 pathway represent well-documented targets for preventing and/or treating cancer. Natural products, especially those from medicinal and food plants, are a rich source for the discovery and development of novel therapeutic and preventive agents against human cancers. Many natural product-derived MDM2 inhibitors have shown potent efficacy against various human cancers. In contrast to synthetic small-molecule MDM2 inhibitors, the majority of which have been designed to inhibit MDM2-p53 binding and activate p53, many natural product inhibitors directly decrease MDM2 expression and/or MDM2 stability, exerting their anticancer activity in both p53-dependent and p53-independent manners. More recently, several natural products have been reported to target mutant p53 in cancer. Therefore, identification of natural products targeting MDM2, mutant p53, and the p53-MDM2 pathway can provide a promising strategy for the development of novel cancer chemopreventive and chemotherapeutic agents. In this review, we focus our discussion on the recent advances in the discovery and development of anticancer natural products that target the p53-MDM2 pathway, emphasizing several emerging issues, such as the efficacy, mechanism of action, and specificity of these natural products.

To Read the Info - Click on the Link Below:

Link 1 : "Research Paper"
or Go To
https://www.sciencedirect.com/science/article/pii/S2352304218300758?via%3Dihub

Us Too Warriors,
Up your amount of Curcumin - It stops mTOR a metastasis promotor in PCa & also destabilizes MGMT to block Alzheimer's growth

Us Too Warriors,

If you have been with Us Too for awhile you have heard me recommend Curcumin (lef.org) and know I would take as many as 12 pills per day. I have been taking 4 to 8 pills for the last year but after reading papers below I am going back to 12 pills. The reason for my increase is that in one of the papers below comparing various inhibitors of mTOR the graph shows you need a good amount of Curcumin to lower the mTOR. If you take less than enough it does no good and you are wasting your money. I want to add in passing that mTOR grows many cancers including bladder and brain cancers. My first experience with this mTOR pathway was when one of our members with Metastases to his SKull bone went to John Hopkins for a clinical trial for Rapamyacin, a drug that blocks mTOR. He was on it for at least 2 years and it cleared up his Mets. Rapamycin is hard to get because it is not considered standard of care. Curcumin is not hard to get.

mTOR also promotes Alzheimer's which is a concern in My family so blocking mTOR is something important to my family besides in cancers.

I also found that Supplement "Fisitin" I take as aromatase to block estrogen formation from my testosterone also blocks mTOR. ( that's a bonus)

Best
Peter

Past, Current, and Future Strategies to Target ERG Fusion-Positive Prostate Cancer
Abstract:
The ETS family member ERG is a transcription factor with physiological roles during development and in the vascular and hematopoietic systems. ERG oncogenic activity characterizes several malignancies, including Ewing's sarcoma, leukemia and prostate cancer (PCa). In PCa, ERG rearrangements with androgen-regulated genes-mostly TMPRSS2-characterize a large subset of patients across disease progression and result in androgen receptor (AR)-mediated overexpression of ERG in the prostate cells. Importantly, PCa cells overexpressing ERG are dependent on ERG activity for survival, further highlighting its therapeutic potential. Here, we review the current understanding of the role of ERG and its partners in PCa. We discuss the strategies developed in recent years to inhibit ERG activity, the current therapeutic utility of ERG fusion detection in PCa patients, and the possible future approaches to target ERG fusion-positive tumors.

To Read the Info - Click on the Link Below:

Link 1 : "Hitting the Golden TORget: Curcumin’s Effects on mTOR Signaling"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638063/#__ffn_sectitle

Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt/mTOR pathway: go four better to treat bladder cancer

Link 2 : "Bladder cancer"
or Go To
http://rvaprostatecancersupport.org/PDF/7 14 22 Khan2020_Article_ResveratrolCurcuminPaclitaxelA.pdf

Potential natural mTOR inhibitors screened by in silico approach and suppress hepatic stellate cells activation

Link 3 : "mTOR"
or Go To
https://www.tandfonline.com/doi/abs/10.1080/07391102.2017.1411295?journalCode=tbsd20&_ga=2.257707083.1560075554.1657828666-1040706182.1657828666#

Dietary flavonoid fisetin: A novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management

Link 4 : "Fisetin"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813433/#

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies

Link 5 : "Alzheimer"
or Go To
https://www.tandfonline.com/doi/full/10.1080/14737175.2017.1244482?scroll=top&needAccess=true

******************************************
Us Too Warriors,
NEW Prostate cancer Mutation TMPRSS2-ERG Gene Fusion paper applies to 50+% men with PCa

Us Too Warriors,

Past, Current, and Future Strategies to Target ERG Fusion-Positive Prostate Cancer

Francesca Lorenzini 1,* and Francesca Demichelis1,2,3,1Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento,38123 Trento, Italy2The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine,Weill Cornell Medical College, New York, NY 10021, USA3The Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine,New York, NY 10021, USACorrespondence: francesca.lorenzin@unitn.it (F.L.); f.demichelis@unitn.it (F.D.)

Simple Summary:
In addition to its role in development and in the vascular and hematopoietic systems, ERG plays a central role in prostate cancer. Approximately 40–50% of prostate cancer cases are characterized by ERG gene fusions, which lead to ERG overexpression. Importantly, inhibition of ERG activity in prostate cancer cells decreases their viability. Therefore, inhibiting ERG might represent an important step to improve treatment efficacy for patients with ERG-positive prostate tumors. Here, we summarize the attempts made over the past years to repress ERG activity, the current use of ERG fusion detection and the strategies that might be utilized in the future to treatERG fusion-positive tumors.Abstract:The ETS family member ERG is a transcription factor with physiological roles during development and in the vascular and hematopoietic systems. ERG oncogenic activity characterizes several malignancies, including Ewing’s sarcoma, leukemia and prostate cancer (PCa). In PCa,ERGrearrangements with androgen-regulated genes—mostlyTMPRSS2—characterize a large subset of patients across disease progression and result in androgen receptor (AR)-mediated overexpression ofERG in the prostate cells. Importantly, PCa cells overexpressing ERG are dependent on ERG activity for survival, further highlighting its therapeutic potential. Here, we review the current understanding of the role of ERG and its partners in PCa. We discuss the strategies developed in recent years to inhibit ERG activity, the current therapeutic utility of ERG fusion detection in PCa patients, and the possible future approaches to target ERG fusion-positive tumors

In another paper recently found that this mutation leads principle to Bone metastasis. This fits with my experience of a right hip bone metastasis detected in December 2017 by Axumin Scan at VCU when my cancer levels PSA =24.4 ng/ml.

Best
Peter

Past, Current, and Future Strategies to Target ERG Fusion-Positive Prostate Cancer
Abstract:
The ETS family member ERG is a transcription factor with physiological roles during development and in the vascular and hematopoietic systems. ERG oncogenic activity characterizes several malignancies, including Ewing's sarcoma, leukemia and prostate cancer (PCa). In PCa, ERG rearrangements with androgen-regulated genes-mostly TMPRSS2-characterize a large subset of patients across disease progression and result in androgen receptor (AR)-mediated overexpression of ERG in the prostate cells. Importantly, PCa cells overexpressing ERG are dependent on ERG activity for survival, further highlighting its therapeutic potential. Here, we review the current understanding of the role of ERG and its partners in PCa. We discuss the strategies developed in recent years to inhibit ERG activity, the current therapeutic utility of ERG fusion detection in PCa patients, and the possible future approaches to target ERG fusion-positive tumors.

To Read the Info - Click on the Link Below:

Link 1 : "Gene Fusion Papers"
or Go To
https://pubmed.ncbi.nlm.nih.gov/35267426/

******************************************************************************************
Us Too Warriors,
Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer

Us Too Warriors,

The abstract below also gives the basis for how and why myself made drug treatment works after casodex or Xtandi fail.

Best
Peter

Abstract:
Purpose:
Enzalutamide, a second-generation antiandrogen, was recently approved for the treatment of castration-resistant prostate cancer (CRPC) in patients who no longer respond to docetaxel. Despite these advances that provide temporary respite, resistance to enzalutamide occurs frequently. Androgen receptor (AR) splice variants such as AR-V7 have recently been shown to drive castration-resistant growth and resistance to enzalutamide. This study was designed to identify inhibitors of AR variants and test its ability to overcome resistance to enzalutamide.

To Read the Info - Click on the Link Below:

Link 1 : "Niclosamide"
or Go To
https://pubmed.ncbi.nlm.nih.gov/24740322/
*
Niclosamide jumps the hurdle of enzalutamide resistance

Jerry Deans' cancer failure initially was from Xtandi CRPC before it metastasized so much. Treatment for V7 - may have helped him at that initial stage but it was not widely known or were there any clinical trials that would allow Doctors to prescribe it or FDA approved. He fought valiantly with what was available to him through many cutting edge doctors and trials. You should now know through my efforts that you can arm yourself with some of your own effort and my help to protect you from the scourge of V7. Best Peter

What follows are Journal Editorial comments on treating V7

Link 2 : "Hurdle"
or Go To
https://www.nature.com/articles/nrurol.2014.160
*
Us Too Warriors, You should know about this test. I had not heard of it but as you can see this paper came out in 2016. I have known about ARV7+ failure of ADT for several years but I did not know or hear that doctors could test for it to see if it was occurring in your CRPC cancer until last week. This test is important to keep in mind in case you become hormone refactory=CRPC as your ADT often fails after a few years. This test can help guide your next treatment.
Website follows and then abstract:

Background - Circulating tumor cells (CTCs) expressing AR-V7 protein localized to the nucleus (nuclear-specific) identify metastatic castration-resistant prostate cancer (mCRPC) patients with improved overall survival (OS) on taxane therapy relative to the androgen receptor signaling inhibitors (ARSi) abiraterone acetate, enzalutamide, and apalutamide.

Link 3 : "AR-V7"
or Go To
https://www.europeanurology.com/article/S0302-2838(16)30857-0/fulltext

******************************************
Us Too Warriors,
Alkalazed water fights PCa - fist page of paper from Dr Snuffy Meyers
Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice

Us Too Warriors,

My Niclosamide treatment uses 9.5 pH water which may be adding to its success to stop PCa.

Best
Peter

Abstract:
The microenvironment of solid tumours is extremely acidic and this condition arises since the precancerous stage. This acidic milieu could therefore provide a useful target for both prophylactic and therapeutic approaches. In TRAMP transgenic mice, an in vivo model of prostate adenocarcinoma (AC), oral administration of alkaline water was devoid of unwanted side effects, and when started from an early age was as effective as NaHCO3 in significantly delaying tumour progression, while when started when prostate tumours were already present, a nonstatistically significant trend in the same direction was detected. These findings indicate that the use of alkalinizing drugs should be considered for chemoprevention and, in association with standard chemotherapy, for treatment of human prostate AC.

To Read the Info - Click on the Link Below:

Link 1 : "Alkalinisation"
or Go To
https://www.tandfonline.com/doi/full/10.1080/14756366.2016.1252760

Us Too Warriors,
Two supplements to add to your PCa cancer fight = Apigenin and Berberine

Us Too Warriors,

You can get these supplements from Swanson Inc. I have been using them for years in my fight. The two websites attached below show how they can help you.

Best
Peter

Berberine Inhibits the Metastatic Ability of Prostate Cancer Cells by Suppressing Epithelial-to-Mesenchymal Transition (EMT)-Associated Genes with Predictive and Prognostic Relevance

Int. J. Med. Sci.2015, Vol. 12 http://www.medsci.org63IInntteerrnnaattiioonnaallJJoouurrnnaallooffMMeeddiiccaallSScciieenncceess2015; 12(1): 63-71. doi: 10.7150/ijms.9982Research PaperBerberine Inhibits the Metastatic Ability of Prostate Cancer Cells by Suppressing Epithelial-to-Mesenchymal Transition (EMT)-Associated Genes with Predictive and Prognostic RelevanceChia-Hung Liu1, Wan-Chun Tang2, Peik Sia2, Chi-Chen Huang3, Pei-Ming Yang2, Ming-Heng Wu4, I- Lu Lai5, Kuen-Haur Lee2 

Abstract:
Background:Over 70% of cancer metastasis from prostate cancer develops bone metastases that are not sensitive to hormonal therapy, radiation therapy, or chemotherapy. The epitheli-al-to-mesenchymal transition (EMT) genetic program is implicated as a significant contributor to prostate cancer progression. As such, targeting the EMT represents an important therapeutic strategy for preventing or treating prostate cancer metastasis. Berberine is a natural alkaloid with significant antitumor activities against many types of cancer cells. In this study, we investigated the molecular mechanism by which berberine represses the metastatic potential of prostate cancer.Methods:The effects of berberine on cell migration and invasion were determined by transwell migration assay and Matrigel invasion assay. Expressions of EMT-related genes were determined by an EMT PCR Array and a quantitative RT-PCR. The prognostic relevance of berberine's modula-tion of EMT-related genes in prostate cancer was evaluated using Kaplan-Meier survival analysis. Results:Berberine exerted inhibitory effects on the migratory and invasive abilities of highly metastatic prostate cancer cells. These inhibitory effects of berberine resulted in significant re-pression of a panel of mesenchymal genes that regulate the developmental EMT. Among EMT-related genes downregulated by berberine, high BMP7, NODAL and Snail gene expressions of metastatic prostate cancer tissues were associated with shorter survival of prostate cancer patients and provide potential therapeutic interventions.Conclusions:We concluded that berberine should be developed as a pharmacological agent for use in combination with other anticancer drug for treating metastatic prostate cancer

To Read the Info - Click on the Link Below:

Link 1 : "Berberine"
or Go To
https://click.endnote.com/viewer?doi=10.7150%2Fijms.9982&token=WzQ4NDQ5LCIxMC43MTUwL2lqbXMuOTk4MiJd.d1NDMtzVJiDmjBUb4PkRUYuB-Yk

Apigenin impedes cell cycle progression at G2 phase in prostate cancer cells

Link 2 : "Apigenin"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174405/

Us Too Warriors,
Website for paper shows Nano Niclosamide Blocks Short V7 testosterone from activating PCa cells after Casodex&Xtandi fail

Us Too Warriors,

This explains why my PCa stopped growing after I started Making and Taking Nano Niclosamide last August !
See this website

Best
Peter
Small Molecule TherapeuticsNiclosamide and Bicalutamide CombinationTreatment Overcomes Enzalutamide- andBicalutamide-Resistant Prostate Cancer
Chengfei Liu1, Cameron M. Armstrong1, Wei Lou1, Alan P. Lombard1, Vito Cucchiara1,Xinwei Gu1, Joy C. Yang1, Nagalakshmi Nadiminty1, Chong-xian Pan2,3,4,Christopher P. Evans1,3, and Allen C. Gao1,3,4
Abstract:
Activation of the androgen receptor (AR) and its splice variantsis linked to advanced prostate cancer and drives resistance toantiandrogens. The roles of AR and AR variants in the develop-ment of resistance to androgen deprivation therapy (ADT) andbicalutamide treatment, however, are still incompletely under-stood. To determine whether AR variants play a role in bicaluta-mideresistance,we developed bicalutamide-resistant LNCaPcells(LNCaP-BicR) and found that these resistant cells express signif-icantly increased levels of AR variants, particularly AR-V7, both atthe mRNA and protein levels. Exogenous expression of AR-V7 inbicalutamide-sensitive LNCaP cells confers resistance to bicalu-tamide treatment. Knockdown of AR-V7 in bicalutamide- andenzalutamide-resistant CWR22Rv1, enzalutamide-resistant C4-2B (C4-2B MDVR), and LNCaP-BicR cells reversed bicalutamideresistance. Niclosamide, a potent inhibitor of AR variants, signif-icantly enhanced bicalutamide treatment. Niclosamide and bica-lutamide combination treatment not only suppressed AR andAR variants expression and inhibited their recruitment to thePSA promoter, but also significantly induced apoptosis inbicalutamide- and enzalutamide-resistant CWR22Rv1 andC4-2B MDVR cells. In addition, combination of niclosamidewith bicalutamide inhibited the growth of enzalutamide-resis-tant tumors. In summary, our results demonstrate that ARvariants, particularly AR-V7, drive bicalutamide resistance andthat targeting AR-V7 with niclosamide can resensitize bicalu-tamide-resistant cells to bicalutamide treatment. Furthermore,combination of niclosamide with bicalutamide inhibits enza-lutamide resistant tumor growth, suggesting that the combi-nation of niclosamide and bicalutamide could be a potentialcost-effective strategy to treat advanced prostate cancer inpatients, including those who fail to respond to enzalutamidetherapy.Mol Cancer Ther; 16(8); 1521–30.Ó2017 AACR

To Read the Info - Click on the Link Below:

Link 1 : "Nano Niclosamide"
or Go To
https://click.endnote.com/viewer?doi=10.1158%2F1535-7163.mct-16-0912&token=WzQ4NDQ5LCIxMC4xMTU4LzE1MzUtNzE2My5tY3QtMTYtMDkxMiJd.FmeKKeHf6zuTalW_1CjsbS8SmNs

\
Us Too Warriors,
A new type Prostate cancer Cell Type discovered ==> SCL = Stem Cell Like cancer Cells

Us Too Warriors,

Check this website for information about this cell type which seems to apply to 30% of PCa. The only other two detected so far are Androgen dependent which accounts for over 50% and NeuroEndocrine (~10%?) that develops later usually during treatment often and is harder to treat.

Genetic mutations modify how these cancers act and respond to treatment .

At this time it is not clear how to detect SCL PCa or treat it as this is the early stage in the research.

Best
Peter
A previously unknown subtype of hormone-resistant prostate cancer accounts for about 30% of all cases, according to a new study from a team of scientists at Memorial Sloan Kettering Cancer Center (MSK) and Weill Cornell Medicine, published May 27, 2022, in the journal Science. The results could pave the way for targeted therapies for people with this subtype of prostate cancer.

To Read the Info - Click on the Link Below:

Link 1 : "Cell Type"
or Go To
https://www.mskcc.org/news/msk-scientists-identify-new-and-very-common-subtype-prostate

Us Too Warriors,
U.S. Preventive Services Task Force (USPSTF) in 2012 and May 2022 gave PSA screening for PCa a Grade of D

Us Too Warriors,
Did Change in PSA-Based Screening Recommendation Hinder Prostate Cancer–Specific Survival?
( YES!!! Peter Moon's Comment)
Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "PSA-Based Screening"
or Go To
http://rvaprostatecancersupport.org/PDF/6 3 22 Based Screening.pdf

*
Us Too Warriors,
MoonShoot by US Goverment = better screening of PCa to stop Mets & men from dying, Bone scaning & Gleason scoring & profile of Advanced cancer
Patient Profile 3: High-Risk Prostate Cancer

Us Too Warriors,

The articles in "Urology Times" may help you do a better in treating your cancer found at this website that follows below.

Best
Peter

To see the Video/Article - Click on the Link Below:

Link 1 : "MoonShoot"
or Go To
https://www.urologytimes.com/view/patient-profile-3-high-risk-prostate-cancer

*
Us Too Warriors,
Anemia in Men With Advanced Prostate Cancer: Incidence, Etiology, and Treatment

Us Too Warriors,
My older brother has had PCa for 29 years and recently his Iron level was Measured at 6% saturation in his transferrin molecules. He recently went to the emergency room because he had chest pains which can be caused by low Iron causing the heart muscles not to get enough oxygen so they are painful. ( He was not having a heart attack). Normal IRON is between 30 and 40 % saturation. I am 24 % saturated recently when I am usually between 30 to 40% saturated. Coffee and Tea drinking will sequester iron out of the body and Citrus or vitamin C pills help increase iron absorption from food like meats etc.
Best
Peter

Abstract:
Anemia associated with advanced prostate cancer is a common occurrence. This article reviews the incidence and examines the various causes of this condition, including androgen deprivation, nutritional decline, bone marrow infiltration, treatment-related toxicity, and the chronic inflammatory state. Treatment of anemia in men with advanced prostate cancer is also discussed. In patients with limited bone marrow reserve, blood transfusions may be the only effective treatment. [Rev Urol. 2004;6(1):1-4]

To read the Info - Click on the Links Below:

Link 1 : "Anemia"
or Go To
http://rvaprostatecancersupport.org/PDF/4 27 22 Anemia.pdf

*
Us Too Warriors,
Doxycycline benefit in blockoing MMPs ---- Metrix Metalloproteinases to slow Prostate cancer
and
Five Bacteria in the Urine have been associated with aggressive prostate cancer in patients

Us Too Warriors,
From the Paper - See Link below :
"In conclusion, our results indicate that doxycycline inhibits the expression of various MMPs and NF-kB signaling may have a role in the regulation of the expression of MMPs in LPS-induced PC3 human prostate cancer cells. The results of the present study may help to clarify the cellular mechanisms of the inhibitory effect of doxycycline at subantimicrobial dose in LPS-induced PC3 cells and to encourage future use of doxycycline as an additional novel therapeutic agent in prostate cancer treatment."

I worked on treating the damage of MMPs on teeth (tooth decay breakdown of Collagen) and destruction of the collagen of the periodontal ligament in Perio disease (so teeth fall out) We used Doxycycline chips, silver fluoride solutions and anti-MMP mouthwashes to stop bacterial inflammation that releases damaging MMPs during my 49 years at VCU . I will be going next week to the VCU Nano Microscope lab to examine the size of a Drug mix particles I am using to treat my cancer that has been working to stop my PSa rise.

Best
Peter

To read the Info - Click on the Links Below:

Link 1 : "Doxycycline"
or Go To
http://rvaprostatecancersupport.org/PDF/4 21 22 Doxycycline.pdf

and

Us Too Warriors, I have been taking 100mg /day of Doxycycline antibiotic to fight PCa for over 20 years- This 100mg dose is below the antibiotic dose of 200 mg /day and I have not noticed any problem over the years. I can not remember the research that started me on this path, but the papers below may support this path.
Best Peter

Link 2 : "Microbiomes of Urine"
or Go To
http://rvaprostatecancersupport.org/PDF/4 21 22 Microbiomes of Urine.pdf

Link 3 : "Five types of bacteria linked to aggressive prostate cancer"
or Go To
http://rvaprostatecancersupport.org/PDF/4 21 22 Five types of bacteria linked to aggressive prostate cancer.pdf

*
Us Too Warriors,
Comparison of CT scans (poor) with PSMA Pet and Axumin Scans (both much better than Ct scan)

Us Too Warriors,
You need a good scan to make the best decision for your treatment. The information to follow will help you understand the scans available to get a good one for you.

Below are two discussions that Show Axumin and PSMA Pet scans are much better than CT Scans for Detecting PCa Mets.
Best
Peter

To read the Blog - Click on the Link Below:

Link 1 : "Scans"
or Go To
http://rvaprostatecancersupport.org/PDF/4 16 22 PSMA PET.pdf

*
Us Too Warriors,
Paper on how Melatonin excludes/kicks the activated androgen receptor
out of cell Nucleus to prevent the Dividing/growth of PCa cells

Us Too Warriors,
Melatonin is taken before bedtime to aid in sleep but as the paper below shows not only does it help recover of the day's stress by improving sleep it also kicks the activated androgen receptor out the nucleus so the cancer cell can not divide to grow. see below . Melatonin improves blood flow which is good for the brain, muscles and heart unless you are having surgery or internal bleeding.

Best
Peter

To read the Article - Click on the Link Below:

Link 1 : "Melatonin"
or Go To
http://rvaprostatecancersupport.org/PDF/4 1 22 Melatonin.pdf

*
Us Too Warriors,
A new wrinkle on SBRT to fight Enzalutamide & ADT with metastasis failure to fight PCa

Us Too Warriors,
This treatment used high Di Hydrotestosterone DHT) instead of testosterone on cancer cells instead of high dose testosterone as has been tested on cancer patients followed by ADT (Lupron) This "standard" SBRT" treatment has been shown to work in a number of patients (30 t0 50%?)without mets.

This "New Wrinkle'' using DHT is shown to work on cells from PCa mets men but not in a clinical trial on patients and in this cancer planted in mice.

What is interesting about this study is that DHT is expected to grow PCa cancer 10 times faster than testosterone. I have been taking dutasteride =Avodart (prescription drug) for 22 years to block an enzyme called alpha reductase which turns testosterone into DHT which slow my cancer growth from psa=0.30 to 1.0 for over 12 years and has proved by best weapon so far but to work it has to started after prostate surgery biochemical recurrence before the psa goes above 1.0 See below

Best
Peter

To see the Article - Click on the Link Below:

Link 1 : "New Wrinkle"
or Go To
http://rvaprostatecancersupport.org/PDF/3 24 22 Chen-2022-High-dose-androgen-induced-autophag.pdf

*
Us Too Warriors,
Bipolar Androgen Therapy and the Immune System
Part Three: The Potential of Combination Therapy

Us Too Warriors,

The paper below describes research at John Hopkins that shows that increasing testosterone may benefit a group of men to fight PCa. I am going to talk to my oncologist about doing it for me, but I suspect I will have to go to John Hopkins for the treatment or another University center like in Seattle or S.Carolina or New orleans with well known PCa oncologists.

Best
Peter

Some men are exceptional responders to Bipolar Androgen Therapy (BAT). Its pioneer, medical oncologist Samuel Denmeade, M.D., Co-Director of the Johns Hopkins Prostate Cancer Program, has a few patients who have remained on BAT alone for several years. But for many men, the response is temporary; just a few months. Why? Could it have something to do with mutated genes? What about the immune system?

To see the Article - Click on the Link Below:

Link 1 : "Part Three"
or Go To
https://www.pcf.org/c/bipolar-androgen-therapy-and-the-immune-system/

More Matereial - Supraphysiologic Testosterone Induces Ferroptosis and
Activates Immune Pathways through Nucleophagy in Prostate Cancer

Link 2 : "Supraphysiologic Testosterone"
or Go To
http://rvaprostatecancersupport.org/PDF/2 28 22 Kumar-2021-Supraphysiological-testosterone-ind.pdf

***
Us Too Warriors,
Daralutamide and Survival in Metastatic, Hormone Sensitive Prostate Cancer

Us Too Warriors,

I have been a fan of Duralutamide the latest testosterone Receptor blocker on prostate cancer cells and would like to use it as a monotherapy without ADT as I am presently doing with Casodex an early testosterone Receptor blocker on the cancer . The only way to get Daralutamide as a monotherapy, I have heard of, is to get the Duralutamide, is to get and take the Duralutamide pills and get ADT in the newest version as a pill ( Spelled something like Orv,,,,,,y) and not take these ADT pills. I have only heard of one person doing this and have not heard the results, but my Casodex monotherapy reduced my PSA by 99.9% and stopped my hip metastasis started 4 years ago. Casodex ability started to wain after 2 1/2 and now though still using it I am adding a new trick using solubilized Niclosamide that is supposed to according to research to restore Casodex's and Xtandi's punch and this new self made treatment has been working stopping the PSA doubling time of 5months and reducing the PSA by 10% over a four month period of treatment. I hope to disclose the process in a meeting in April or May as Covid I pray continues to wain.

The paper attached below shows the benefit of Duralutamide when used with ADT (which is a bad actor with such problems as weight gain, loss of mobility, muscle strength,, decreased brain function and increased heart failure among others) my oldest brother on Xtandi and ADT has experienced some of them (after being on it for about four years before dropping it). I have been able to reverse/slow his psa rise over the last three years with several off label supplements/treatments. He had Prostate surgery 29 years ago- so he is a trooper. He is on Casodex monotherapy (150mg/d) and dutasteride 0.5 mg/day now like me.
Best
Peter

Abstract
BACKGROUND
Darolutamide is a potent androgen-receptor inhibitor that has been associated with increased overall survival among patients with nonmetastatic, castration-resistant prostate cancer. Whether a combination of darolutamide, androgen-deprivation therapy, and docetaxel would increase survival among patients with metastatic, hormone-sensitive prostate cancer is unknown.

To see the Information - Click on the Link Below:

Link 1 : "Darolutamide"
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/147627062/daralutamide-and-survival-in-metastatic-hormone-sensitive-prostate-cancer

*
Us Too Warriors,
Dexamethasone is better for use with Zytiga then or after Prednisone for PCa survival

Us Too Warriors,

Objective:
To evaluate the effects of switching from prednisone (P) to dexamethasone (D) at asymptomatic prostate-specific antigen (PSA) progression in patients with metastatic castrationresistant prostate cancer (mCRPC) treated with abiraterone acetate (AA).

Best
Peter

To see the Info - Click on the Link Below:

Link 2 : "Dexamethasone"
or Go To
http://rvaprostatecancersupport.org/PDF/2 21 22 BJU International.pdf

*
Us Too Warriors,
Turkey Tail Mushrooms

Us Too Warriors,

This may be helpful-- I have been using Turkey Tail Mushrooms for many years.

Creatine powers T cells’ fight against cancer Tiare Dunlap | October 18, 2019 Creatine, the organic acid that is popularly taken as a supplement by athletes and bodybuilders, serves as a molecular battery for immune cells by storing and distributing energy to power their fight against cancer, according to new UCLA research. Best
Peter

To see the Info - Click on the Link Below:

Link 2 : "Turkey Tail"
or Go To
http://rvaprostatecancersupport.org/PDF/2 16 22 Turkey Tail .pdf

*
Us Too Warriors,
Sjöberg Prize awarded for cause of prostate cancer discovery
February 15, 2022 - Health Europa

Us Too Warriors,

This fusion defect may be the cause of your cancer( 50% chance) which makes it very responsive Di/Testosterone and it therefore responds well to T receptor blockers (like Casodex & Xtandi) and T reducers like dutasteride(avodart) and finasteride(proscar). By stating when my BCR after surgery had a PSA less than 1.0 (actually 0.3) I kept my psa increasing slowly for 13 years until it reached before it got above 1.0 which research by Dr. Gearald Androile in St louis showed it takes off like mine did for 4 years until I started Casodex in Dec 2017. I am still on it but it is slowly losing its punch after 4 years in which it dropped my psa by 99.9 %. It is back to.3 now as it was 1999 but doubling at least every 5 months or less. I am developing another horse to ride which I will explain after I work out all the details at meeting when or Email when I have tested it out. In the mean, I am testing it on my brothers so the clinical trial will have an N=3. Dr Meyers sent me a paper a few years ago talking about Clinical trials with N=1.

See website below for prize ($1 million dollars) for discovering TMPRSS2-ERG fusion gene. Cancer can produce somatic gene mutations which make your cancer get worse. Over the last 28 years so I have taken antioxidants and inflammatoires to slow this from occurring as well as diet and exercise.

Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Fusion Defect"
or Go To
https://www.healtheuropa.eu/sjoberg-prize-awarded-for-cause-of-prostate-cancer-discovery/113544/

*********************************************
Us Too Warriors,
Body fat linked to lower bone density, particularly in men
February 14, 2022 - By Mary Chris Jaklevic - FROM THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Us Too Warriors,

Read this and see what you can do with diet and exercise to reduce your waist size - I am.

Fat tends to make PCa more aggressive because the protective vitamin D is absorbed in fat cells and is not available to protect against cancer and grow bones. Also, more estrogen is produced that can go to estrogen's alpha receptor to grow the cancer.

Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Body Fat"
or Go To
https://www.mdedge.com/endocrinology/article/251748/osteoporosis/body-fat-linked-lower-bone-density-particularly-men

*************************************************
Us Too Warriors,
Bipolar Androgen Therapy - BAT to fight PCa?
January 24, 2022 | By JANET FARRAR WORTHINGTON

Us Too Warriors,

Could More Testosterone Be the Hidden Key to Fighting Prostate Cancer? Researchers Drive Prostate Cancer “BATty” - Part One: The Concept of BAT

Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "BAT to fight PCa"
or Go To
https://www.pcf.org/c/could-more-testosterone-be-the-hidden-key-to-fighting-prostate-cancer-part1/

*
Us Too Warriors,
Check this website for news you can use.

Testing Breakthrough in Diagnosing Prostate Cancer

See Below - Best
Peter

To see the Info - Click on the Links:

Link 1 : "Breakthrough"
or Go To
https://www.cancerdefeated.com/testing-breakthrough-in%e2%80%a8-diagnosing-prostate-cancer/
*****************************************
Us Too Warriors,
I tried Modified Citrus Pectin many years ago as it was advertised to prevent mets and lower PSA. It was priced at about $100/month & not covered by insurance. The clinical study below I think is at a higher dose than I used - I do not expect the price has decreased. - I am looking to see what it costs now at the higher dose of 15grams /day divided into 3 doses of 5 grams on an empty stomach before meals.

The second off label treatment is CBD oil treatment of (30 +mg/dose), and I am going to increase dosing to 3 times a day which will increase the cost to $70/month and I hope to improve its effectiveness too.

See Below - Best
Peter

Introduction
With over 207,000 newly diagnosed cases in the U.S. annually, prostate cancer is the second most widespread cancer in men in the U.S. [1]. While localized treatment modalities often cure patients with localized disease, approximately 30% demonstrate biochemical relapse at ten years. The ideal management of these patients remains elusive at present. Radiation treatment given for suspected recurrent malignant disease after a period of observation after prostatectomy, also known as salvage radiation therapy (SRT), provides long-term benefits in some patients, and the use of androgen deprivation treatment (ADT) continues to be debatable [2]. While ADT effectively reduces serum PSA levels in the majority of patients, its long-term benefits on survival and quality of life remain unclear. Data emphasize the incidence of accumulative toxicities with ADT, which may offset any potential survival benefit from early intervention and impact the life quality [3].

To see the Info - Click on the Links:

Link 1 : "Citrus Pectin"
or Go To
https://www.mdpi.com/2072-6643/13/12/4295/htm
*
Simple Summary:

The use of cannabinoids containing plant extracts as herbal medicine can be traced back to as early as 500 BC. In recent years, the medical and health-related applications of one of the non-psychotic cannabinoids, cannabidiol or CBD, has garnered tremendous attention. In this review, we will discuss the most recent findings that strongly support the further development of CBD as a promising anti-cancer drug.

Link 2 : "Cannabidiol (CBD) as a Promising Anti-Cancer Drug"
or Go To
http://rvaprostatecancersupport.org/PDF/1 15 22 cancers-12-03203.pdf

*****************************************
Us Too Warriors,
I have been providing my wife with CBD oil (from Hemp) for about three years which has overcome her thirty years of Pain, fatigue and poor sleep from Fibromyalgia. My wife takes a dose of 25 to 30 mg of liquid CBD oil per night before going to sleep from a dropper.

It (CBD OIL) now appears to help fight covid. My interest in CBD oil came from studies that suggest it may fight PCa. I tried a bottle 5 years ago and did not see much benefit for my cancer. I had half a bottle left and got my wife to try it - She liked it and I have been supplying her at over $1000/year since then. I am going to give it another look for PCa. I am attaching a paper on the end of this email on its benefit for PCa studies in animals. See the following:

See Below - Best For the New Year
Peter

To see the Info - Click on the Links:

Link 1 : "CBD 1"
or Go To
http://rvaprostatecancersupport.org/PDF/1 13 22.pdf

Link 2 : "CBD 2"
or Go To
http://rvaprostatecancersupport.org/PDF/1 13 22 CBD might help prime cells against COVID.pdf

*
Us Too Warriors,
Paper attached that suggest Flavanoids that help with Covid-19 - See The Flavanoids in Figure 1, I also take to fight PCa too !!!

See Below - Best For the New Year
Peter

ABSTRACT:

In terms of public health, the 21st century has been characterized by coronavirus pandemics: in 2002-03 the virus SARS-CoV caused SARS; in 2012 MERS-CoV emerged and in 2019 a new human betacoronavirus strain, called SARS-CoV-2, caused the unprecedented COVID-19 outbreak. During the course of the current epidemic, medical challenges to save lives and scientific research aimed to reveal the genetic evolution and the biochemistry of the vital cycle of the new pathogen could lead to new preventive and therapeutic strategies against SARS-CoV-2. Up to now, there is no cure for COVID-19 and waiting for an efficacious vaccine, the development of “savage” protocols, based on “old” anti-inflammatory and anti-viral drugs represents a valid and alternative therapeutic approach. As an alternative or additional therapeutic/preventive option, different in silico and in vitro studies demonstrated that small natural molecules, belonging to polyphenol family, can interfere with various stages of coronavirus entry and replication cycle. Here, we reviewed the capacity of wellknown (e.g. quercetin, baicalin, luteolin, hesperetin, gallocatechin gallate, epigallocatechin gallate) and uncommon (e.g. scutellarein, amentoflavone, papyriflavonol A) flavonoids, secondary metabolites widely present in plant tissues with antioxidant and anti-microbial functions, to inhibit key proteins involved in coronavirus infective cycle, such as PLpro, 3CLpro, NTPase/helicase. Due to their pleiotropic activities and lack of systemic toxicity, flavonoids and their derivative may represent target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections.

To see the Info - Click on the Link Below:

Link 1 : "Flavanoids"
or Go To
http://rvaprostatecancersupport.org/PDF/1 2 22 Russo-2020-Roles-of-flavonoids-against-corona.pdf

*
Us Too Warriors,
Use of Prolactin blocker drug to "CURE" ADT refractory PCa
Us Too Warriors,

This is the first "cure" for cancer at this stage (ADT resistant) I have seen. If you are on ADT you may find this exciting. I have been using a low dose of Cabergoline for years as recommended by Dr. Snuffy Meyers even though I am not on ADT.

See Below - Best For the New Year
Peter

Conclusions:

This report of a novel chemotherapy for androgen-independent malignancy corroborates our understanding of the implications of prolactin in its development and treatment. There are about 165,000 cases/year with 25,000 deaths/year in the U.S.; and 1.0 million cases/year with 260,000 deaths/year worldwide. Those patients with androgen-independent prostate cancer can now employ this cabergoline treatment to prevent or terminate this deadly type of prostate cancer.

To see the Info - Click on the Link Below:

Link 1 : "CURE"
or Go To
http://rvaprostatecancersupport.org/PDF/12 27 21 nihms.pdf

*
Us Too Warriors,
2021 Top Story in Prostate Cancer: An Inflection Point — The Dawn of PSMA Theranostics
Us Too Warriors,
Keep Jerry in your prayers. His cancer is extensive and showing up in his Brain, Lungs and Bones beside lymph nodes. He has had
all these areas treated with SBRT with some benefit. He is trying a new treatment called Lu 177 which has a good promise to help
in his fight. We wish him all the best in his trip to Chicago. I have added this website below to help you know about LU 177.
All the Best for the coming year. See below.
Best
Peter

To see the Website - Click on the Link Below:

Link 1 : "Inflection Point"
or Go To
https://www.practiceupdate.com/c/127381/68/3/?elsca1=emc_coll_2021TopStories2&elsca2=email&elsca3=practiceupdate_uro&elsca4=2021TopStories2&elsca5=collection&rid=NTU2MjE4MTA4NzMS1&lid=10705082

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Us Too Warriors,
Understanding Precision Medicine for your PCa or any cancer
Us Too Warriors,
See Paper attached - Knowing the Mutation in My genes (TMPRSS2-ERG fusion) has helped me find treatments that work. The paper attached speaks to many of the known mutations and treatments that work for them in PCa. This paper did not have an answer for my mutation but my research found an answer. So once you know your mutation thru gene analysis you can go on line and find the latest research papers - You need to keep looking as new papers are coming out all the time.

To see the Info - Click on the Link Below:

Link 1 : "Precision"
or Go To
http://rvaprostatecancersupport.org/PDF/12 11 21 Precision.pdf

*
Us Too Warriors,
Avodart an alpha redutase inhibitor that stops the growth of PCa with TMPRSS2-ERG Mutations(which occurs in 50% of men w/PCa)
Us Too Warriors,
See Paper attached - I started proscar in 2000 with a BCR (PSA= 0.29 6 yrs after surgery) and added Avodart in 2003 so I have used both for now for 18 years. For 13 of those years, it kept my cancer only growing slowly (PSA <1.3) because I have PCa with TMPRSS2-ERG Mutations from gene analysis by blocking the formation of Dihydrotestosterone which grows PCa 10X faster than testosterone alone.
PS. I suggest that you add Avodart to your treatment to see if you are in the 50% with TMPRSS2-ERG Mutations in their PCa,

To see the Info - Click on the Link Below:

Link 1 : " Avodart "
or Go To
http://rvaprostatecancersupport.org/PDF/12 11 21 Variability.pdf

***********************************************
Us Too Warriors,
Ivermectin (same Catergory as Niclosamide) inhibits Gastric cancer and Prostate cancer spread as anti-protease

Us Too Warriors,
See Paper attached - Generic form costs 6 cents per serving to make.
Best for the Holidays

See below.
Best
Peter

Ivermectin, a potential anticancer drug derived from an antiparasitic drug

ABSTRACT
Ivermectin is a macrolide antiparasitic drug with a 16-membered ring that is widely used for the treatment of many parasitic diseases such as river blindness, elephantiasis and scabies. Satoshi omura ¯ and William C. Campbell won the 2015 Nobel Prize in Physiology or Medicine for the discovery of the excellent efficacy of ivermectin against parasitic diseases. Recently, ivermectin has been reported to inhibit the proliferation of several tumor cells by regulating multiple signaling pathways. This suggests that ivermectin may be an anticancer drug with great potential. Here, we reviewed the related mechanisms by which ivermectin inhibited the development of different cancers and promoted programmed cell death and discussed the prospects for the clinical application of ivermectin as an anticancer drug for neoplasm therapy.

IVERMECTIN not only has strong effects on parasites but also has potential antiviral effects. IVM can inhibit the replication of flavivirus by targeting the NS3 helicase [17]; it also blocks the nuclear transport of viral proteins by acting on α/β-mediated nuclear transport and exerts antiviral activity against the HIV-1 and dengue viruses [18].

To see the Info - Click on the Link Below:

Link 1 : "Ivermectin"
or Go To
http://rvaprostatecancersupport.org/PDF/12 9 21 Ivermectin.pdf

***
Us Too Warriors,
Dietary Compounds that fight cancer

Us Too Warriors,
Please read the attached paper to find what you can do (without your docs help) to fight cancer. The paper represents the many supplements and foods I have used to stop my cancer. Next year I will send out my latest treatment protocol after it has stopped my cancer for 6 months running. It has been working for four months so far - Before it was doubling every 4 months.
Best for the Holidays

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Dietary Compounds"
or Go To
http://rvaprostatecancersupport.org/PDF/11 29 21 Carlos-Reyes.pdf

*
Us Too Warriors,
Statins like Pravastatin blocks "ROCK" = ROCK inhibitor which keeps cancers for spreading
(I researched this for a nephew w/Gastric cancer)

Us Too Warriors,
I have Taken Pravastatin for several years and researched it then when my GP Doctor prescribed it. I found a paper showing that it would slow PCa growth by 38%.

I also take 200 to 300 mg of CoQ10 /day along with the statin (all of them) because it can be hard on the muscles as per Research by Dr. Snuffy Meyers to the point the muscles will shrink and be painful.

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Statin"
or Go To
http://rvaprostatecancersupport.org/PDF/11 25 21 Statin.pdf

*************************************************
Us Too Warriors,
blog on " PSA rising on BAT" ==> Replies suggest how to treat it

Us Too Warriors,
This blog discusses how to do BAT treatment and by controlling DHT to keep PSA from rising by using Avodart block DHT but you have to start your Avodart at aPCA below <1.0 mine was 0.29 because I did my research as soon as the PSA came back at 5 years after surgery. If the PSA is above >1.0 when you start Avodart,

It may be slowed for a year or two before it starts growing more rapidly. I was able to use Avodart after cancer returned after surgery to control my PSA rise after surgery for 13 years. In Dec 1999, PSA = 0.29 and in Dec.2013

PSA =1.2 and Dec. 2014 PSA =2.2 . So it started to grow more rapidly and by Dec. 2017 my PSA had risen to12.2 and an Axumin scan showed mets in my right hip bone and multiple pelvic lymph >6 nodes. One of the things you need to know about Avodart is it reduces PSA put out by half so my cancer cells in December 2017 at 12.2 was actually = to a cancer mass = 24.4 PSA so it was not surprising I had metastasis. My reading of the literature is you can have mets show up with PSA in the mid teen range. see more info about Avodart use with BAT treatment.

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "BAT"
or Go To
http://rvaprostatecancersupport.org/PDF/11 12 21 PSA rising on BAT.pdf

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Us Too Warriors,
Article showing value of PSA testing - Have your Brothers, Nephews& cousins start PSA testing as they reach 40, 45and 50 years!

Us Too Warriors,
If your family has a genetic mutation for prostate cancer (like mine - 3 brothers w/PCa), it is important to start as early as 40 years old with PSA testing so you have a baseline for comparison and you can catch it early before it is dangerous.
Please Send This to the males in your family (even better to the females also) to make sure the males get to the Doctor in time!!

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "PSA Screening"
or Go To
http://rvaprostatecancersupport.org/PDF/11 4 21 PSA Screening.pdf

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Us Too Warriors,
Prostate Cancer treated with ADT Damages 21/2 more failures of the Kidneys and Antiandrogen therapy add is even worse.

Us Too Warriors,
(Link 1)This report is old (2013 ) but news to me. As we age our kidneys work less well as determined by GFR blood test - If you are in the 70 to 80yrs age range if your GFR is in the 70 to 80 ( units?) range, you are doing okay.but when you get down to 30 (units?) in your GFR you are in stage 3 kidney failure.
and
(Link 2)As many of you know I have been using Casodex for ~ 4 years to lower my PSa to undetectable for 3 of those years.

But the attached paper raises some concern about kidney function problems to the extent that the paper suggests adding testosterone to the treatment which is unusual as often casodex is used with ADT which lowers testosterone (an may not recover off of Antiandrogens like casodex etc) and does lead to kidney failure as in the last paper I sent earlier today. However, Casodex blocks testosterone from getting into cells particularly cancer cells so adding testosterone is unusual but may be necessary if you have low testosterone?

I am unusual in that I have very high testosterone ( I have never been on ADT) at 850 to 1500 units. So my kidneys have been OK with a GFR of 70 units at 81 yrs.. But if you have been on ADT or naturally have lower testosterone <450 units you may need to take some amount of testosterone to protect your kidneys as they need it to function well and if you have low kidney function testosterone may help. My Brother has low T after being on Xtandi and lupron (ADT), so he may need to talk to his Doctor about getting some testosterone patches or Injections to protect his kidneys.

This opens the questions about the effects of other Antiandrogens (besides casodex)like Xtandi, Apalutamide, Nubecqa etc on kidneys) especially when used with ADT & low testosterone Men?

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "ADT Damages"
or Go To
http://rvaprostatecancersupport.org/PDF/10 31 21 ADT Damages.pdf

Link 2 : "ADT Damages 2"
or Go To
http://rvaprostatecancersupport.org/PDF/10 31 21 ADT Damages 2.pdf

*
Us Too Warriors,
Lycopene to fight Alzheimers, Parkinsons and cancers( stomach and PCa among others)

Us Too Warriors,
Lycopene that I use (40 mg/day from Puritan Pride acts as a blood thinner that lowers blood pressure and helps blood flow to the brain and kidneys for improved function. If you have low blood pressure or are on blood thinners you will need to find out the right amount for you. I have low blood pressure and some of my supplements act as blood thinners so when I had 100+ lycopene per day for a few weeks, I had some excess bleeding which stopped on 40 mg/day. Lycopene that I use (40 mg/day from Puritan Pride acts as a blood thinner that lowers blood pressure and helps blood flow to the brain and kidneys for improved function. If you have low blood pressure or are on blood thinners you will need to find out the right amount for you. I have low blood pressure and some of my supplements act as blood thinners so when I had 100+ lycopene per day for a few weeks, I had some excess bleeding which stopped on 40 mg/day.
and
When you use antioxidants to fight PCa you are also protecting yourself from Covid. In the paper that follows, I am using all but one of the supplements shown in Figure 1 that block ACE2 from getting into your cells to grow Covid. I also take at least 6 green pills a day which chelate iron so it is excreted from my body. I know that excess iron as an oxidant grows PCa and damages the brain. I have been taking green tea pills from lef.org for twenty years.(See Link 2)

ABSTRACT
Lycopene is a naturally occurring carotenoid found abundantly in red fruits and vegetables. Myriads of literature documented potential health benefits of lycopene, owing to its sublime capacity of suppressing oxidative stress, inflammation, and modulation of various cell survival pathways. Due to its lipophilic nature, lycopene can reach brain adequately by traversing the blood-brain barrier thereby extending it’s promising therapeutic benefits in neurological disorders. Lycopene efficiently assists in restoring the characteristic behavioural and pathophysiological changes associated with neurodegenerative disorders, epileptic conditions, aging, subarachnoid hemorrhage, spinal cord injury, and neuropathy. The detrimental impacts of environmental neurotoxins on brain and neuropathological consequences of consumption of high-lipid diet can also be mitigated by lycopene. Apart from its high antioxidant potency, lycopene confers neuroprotection by preventing proteinopathies, neuroinflammation, apoptosis, cerebral edema, and synaptic dysfunction. This review provides a lucid idea on the potential multi-faceted benefits of lycopene in disorders of the central nervous system and elucidates the molecular mechanisms and pathways of its action.

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Lycopene"
or Go To
http://rvaprostatecancersupport.org/PDF/10 31 21 Lycopene.pdf

Link 2 : "COVID-19"
or Go To
http://rvaprostatecancersupport.org/PDF/10 31 21 Coivid19.pdf

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Us Too Warriors,
Exercise study proves better heart and slower PSA climb for men exercising on Active surveillance for PCa

Us Too Warriors,
Effects of Exercise on Cardiorespiratory Fitness and Biochemical Progression in Men With Localized Prostate Cancer Under Active Surveillance The ERASE Randomized Clinical Trial

Dong-Woo Kang, PhD; Adrian S. Fairey, MD; Normand G. Boulé, PhD; Catherine J. Field, Ph

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Exercise"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 21 Exercise.pdf

*
Us Too Warriors,
SARMs a new area of off label Drug/supplement that may or may not benefit PCa -seems best for muscle and bone loss with age or cancer

Us Too Warriors,
This is a new area, SARMs (Selective Androgen Receptor Modulators) , of investigation for me. I do not claim to know the answers. I have attached some papers that may discuss SARMs for your examination with no recommendation on my part except to inform you that the area exists. SARMs exist in a gray area in that they are not FDA approved or controlled so it is buyer beware. But they may be helpful with age or weight/muscle loss from cancer. See below. best peter

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Androgen Receptor Modulator"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 21 Androgen Receptor Modulator .pdf

Link 2 : "SARMs"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 21 SARMs.pdf

Link 3 : "Selective Androgen Receptor"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 21 Selective androgen receptor.pdf

Link 4 : "Future of Androgen"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 b21 future of androgen.pdf

*
Us Too Warriors,
SARMs a new area of off label Drug/supplement that may or may not benefit PCa -seems best for muscle and bone loss with age or cancer

Us Too Warriors,
This is a new area, SARMs (Selective Androgen Receptor Modulators) , of investigation for me. I do not claim to know the answers. I have attached some papers that may discuss SARMs for your examination with no recommendation on my part except to inform you that the area exists. SARMs exist in a gray area in that they are not FDA approved or controlled so it is buyer beware. But they may be helpful with age or weight/muscle loss from cancer. See below. best peter

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Androgen Receptor Modulator"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 21 Androgen Receptor Modulator .pdf

Link 2 : "SARMs"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 21 SARMs.pdf

*
Us Too Warriors,
Supraphysiological testosterone induces ferroptosis and activates immune pathways through nucleophagy in prostate cancer

Us Too Warriors,
Research at John Hopkins explains how BAT works on PCa
Best
Peter

Abstract:

The discovery that androgens play an important role in the progression of prostate cancer (PCa) led to the development of androgen deprivation therapy (ADT) as a first line of treatment. However, paradoxical growth inhibition has been observed in a subset of PCa upon administration of supraphysiological levels of testosterone (SupraT), both experimentally and clinically. Here we report that SupraT activates cytoplasmic nucleic acid sensors and induces growth inhibition of SupraT-sensitive PCa cells. This was initiated by the induction of two parallel autophagy-mediated processes, namely, ferritinophagy and nucleophagy. Consequently, autophagosomal DNA activated nucleic acid sensors that converge on NF-κB to drive immune signaling pathways. Chemokines and cytokines secreted by the tumor cells in response to SupraT resulted in increased migration of cytotoxic immune cells to tumor beds in xenograft models and patient tumors. Collectively, these findings indicate that SupraT may inhibit a subset of PCa by activating nucleic acid sensors and downstream immune signaling.

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link : "Supraphysiological"
or Go To
https://pubmed.ncbi.nlm.nih.gov/34645612/

Us Too Warriors,
Prostate cancer Met cells functions as Basal or Luminal subtypes which respond differently with ADT and Chemo

Us Too Warriors,
From the papers below - it appears for survival - it is important to know which subtype of PCa you have. From my good response to Hormone/adt treatments, I surmise my cancer is Luminal. The attached paper may be helpful in guiding your treatment.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Link 1"
or Go To
http://rvaprostatecancersupport.org/PDF/9 24 21 jamaoncology_mabaera_2021_ic_210015_1631115307.97663.pdf
and
Link 2 : "Link 2"
or Go To
http://rvaprostatecancersupport.org/PDF/9 24 21 jamaoncology_aggarwal_2021_oi_210061_1631115289.70279.pdf

Us Too Warriors,
Characteristic of Good BAT responders included TP53 Mutations

Us Too Warriors,
This paper can help you determine if you are a good BAT ( Bipolar Androgen Therapy) responder!!!
Best
Peter

To see the Info - Click on the Link Below:

Link : "BAT"
or Go To
http://rvaprostatecancersupport.org/PDF/9 24 21 BAT.pdf

Us Too Warriors,
Chrysin for fighting Prostate and many other cancers

Us Too Warriors,
I have been using Chrysin for about 4 years as an agent to suppress my high testosterone from breaking down into Estrogen which can grow PCa if the estrogen attaches to the Alpha estrogen receptor. But the Attached paper below shows that Chrysin has a much wider way of fighting prostate cancer. See below.
Best
Peter

To see the Info - Click on the Link Below:

Link : "Chrysin"
or Go To
http://rvaprostatecancersupport.org/PDF/9 21 21 Chrysin.pdf

Us Too Warriors,
Single Lab test for detection of Multiple cancers(50+)

Us Too Warriors,
I just heard of The Galleri Lab Test For Cancers - I am just investigating it and do not know much yet but I know cancer can attack you in many organs and as we may focus on Prostate cancer. There are many other sites out there that are to protect and find out early. It is important to survive - My nephew was just diagnosed with advanced stomach cancer which is hard to deal with and I am going to my surgeon Friday to see about surgery for a melanoma (in Situ). This is my 3 or 4th melanoma so I am getting good at spotting them and other skin cancers. But most cancers are hard to detect until they are advanced so this test, if it proves as good as it sounds, is something I will want to do. Check it out for yourself and family, See Below
Best
Peter

To see the Info - Click on the Link Below:

Link : "Single Lab test"
or Go To
https://www.galleri.com/hcp/clinical-evidence

and

Link : "Multiple Cancers"
or Go To
http://rvaprostatecancersupport.org/PDF/9 16 21 Galleri-Cancers-Detected-Chart_061621.pdf

Us Too Warriors,
Bipolar testosterone Paper Attached which agrees with Jerry Deans Improved experience

Us Too Warriors,
Objective :
To investigate whether bipolar androgen therapy (BAT), involving rapid cyclic administration of high-dose testosterone, as a novel treatment for metastatic castration-resistant prostate cancer (mCRPC) promotes improvements in body composition and associated improvements in lipid profiles and quality of life
Best
Peter

To see the Info - Click on the Link Below:

Link : "Bipolar"
or Go To
http://rvaprostatecancersupport.org/PDF/9 10 21 Marshall-2021-Reversing-the-effects-of-androgende.pdf

Us Too Warriors,
List of the Standard of Care recommend by Doctors for PCa at it verus stages for your infornamtion

Us Too Warriors,
Check out this website and compare it to what stage you think your cancer is. This is standard of care and is what most doctors will recommend unless they think outside the Box. As you know by now I think outside the box and I am testing my own concoction with niclosamide this month and hope to test its effect on PSA in the next two weeks. I am trying to see how I can obtain Nubequa antiandrogen as a monotherapy to replace my Casodex monotherapy that had been working well until lately for over 3 years.

Google this website for info
Best
Peter

To see the Info - Click on the Link Below:

Link : "Standard of Care"
or Go To
https://emedicine.medscape.com/article/2007095-overview

Us Too Warriors,
TMPRSS2

Us Too Warriors,
The attached paper is very complex but it suggests that This gene fusion may make Covid more dangerous. TMPRSS2 is one of the means by which Covid gets into our cells to damage them and being Fused to ERG does not seem to help the issue as best I read the paper. I have gotten the booster shot as has one of my brothers and I hope my other brother will too
Best
Peter

To see the Info - Click on the Link Below:

Link : "TMPRSS2"
or Go To
http://rvaprostatecancersupport.org/PDF/9 6 21 main (3).pdf

and

Chemotherapy does not look promising for me or my brothers. You can check to see if you have this gene fusion - if you need too. See attached paper.

Link : "Docetaxel Resistance"
or Go To
http://rvaprostatecancersupport.org/PDF/9 8 21 TMPRSS2.pdf

Us Too Warriors,
Covid Booster

Us Too Warriors,
I have been able to get Covid Booster shots for Myself and wife, Sue. I qualified by being prescribed a high dose prednisone ( at 60 Mg has to be 20 mg or more to qualify as an immune lowering treatment) for oral blistering drug reaction from two prescriptions in a row for tick bites. I was able to get a booster for my wife by showing the pharmacist the two papers showing that Epstein virus lowers the immune system and covid causes reactivation of EBV that is sequestered in the body and results in long Covid Haulers in 2/3 of these patients. EBV caused my wife to suffer Chronic Fatigue/fibromyalgia for 30+ years. It is a real bad actor that causes Mononucleosis in young people ie Kissing disease. It is expected that 95% of the population has been exposed to EBV and have it in their body to be reactivated by covid and may be a cause of higher death rates, So these arguments may apply to you and your family.

I went to CVS and found them hard to deal with for the shot and I found it easier getting the shot at Walmart after talking with pharmacist and pointing out that EBV corresponds to their immunosuppressive syndromes on the sheet of acceptable problems to get a shot.

See Shot info papers attached farther down
Best
Peter

To see the Info - Click on the Link Below:

Link : "Cohen"
or Go To
http://rvaprostatecancersupport.org/PDF/9 5 21 Cohen.pdf

and

Link : "Epstein-Barr"
or Go To
http://rvaprostatecancersupport.org/PDF/9 5 21 Epstein-Barr.pdf

Us Too Warriors,
Tomatoes

Us Too Warriors,
I hope you have been taking advantage of cooking tomatoes this summer because cooking them helps release them from their skin where Lycopene is found and adding some olive oil to the dish will help release it. I am into making my own cancer medicine which is lipidfilic which allows me to dissolve the active drug into olive oil which I also add 40 mg of lycopene released from their capsules by cutting them open. I will know in three weeks if it is working when I get my next PSA test to see if it has dropped or the rate of climb has stalled (presently doubling every 3 months). The paper below describes the advantage of Lycopene in Prostate , Stomach and lung cancers among others.
Best
Peter

To see the Info - Click on the Link Below:

Link : "Tomatoes"
or Go To
http://rvaprostatecancersupport.org/PDF/8 30 21 Giovannucci-1999-Tomatoes.pdf

and

Potential inhibitory effect of lycopene on prostate cancer
Studying prostate cancer is important due to its high annual incidences and mortality rates in the world. Although prostate cancer mortality rates are reduced using new therapy, complicated routes and side effects of these current drugs require a daily available treatment for prevention. Lycopene is a natural, prominent, and effective product which has a high value in diet. The anti-cancer effect, non-toxicity, safety and preventive or therapeutic roles of lycopene have been investigated in several studies. In the current review, we have collected information about the anti-cancer, anti-progressive and apoptotic effects of lycopene on prostate cancer. This article is a summary of the most important original and review articles on lycopene and its anticancer effects that are systematically categorized and presents information about the molecular structure, different sources, biological functions, and its in-vivo and in-vitro effects of lycopene on variety of cancerous and normal cells. The clinical studies provide a clear image for continuous use of this adjunctive dietary for different type of cancers, especially prostate cancer in men. In addition, this article discusses the various molecular pathways activated by lycopene that eventually prevent or suppress cancer. Lycopene has been found to effectively suppress the progression and proliferation, arrest in-cell cycle, and induce apoptosis of prostate cancer cells in both in-vivo and invitro conditions. Additionally, lycopene showed that it could modulate the signaling pathways and their protein for the treatment or prevention of prostate cancer

Link : "lycopene"
or Go To
http://rvaprostatecancersupport.org/PDF/9 1 21 Mirahmadi-2020-Potential-inhibitory-effect-of-lyco.pdf

Us Too Warriors,
Covid

Us Too Warriors,
The following website may help with Covid.

Best
Peter

Do any supplements help with the coronavirus (COVID-19)? Do supplements like vitamin D, zinc, vitamin C, or herbals work? Reviewed and edited by Tod Cooperman, M.D. Tod Cooperman, M.D.
Last Updated: 08/10/2021 | Initially Posted: 03/06/2020

To see the Info - Click on the Link Below:

Link : "Covid"
or Go To
https://www.consumerlab.com/answers/do-natural-remedies-or-supplements-prevent-coronavirus/natural-remedies-coronavirus/

Us Too Warriors,
Ivermectin inhibits HSP27 and potentiates efficacy of oncogene targeting in tumor models

Us Too Warriors,
If you get advanced prostate cancer keep the paper below in mind.

Best
Peter

HSP27 is highly expressed in, and supports oncogene addiction of, many cancers. HSP27 phosphorylation is a limiting step for activation of this protein and a target for inhibition, but its highly disordered structure challenges rational structureguided drug discovery. We performed multistep biochemical, structural, and computational experiments to define a spherical 24-monomer complex composed of 12 HSP27 dimers with a phosphorylation pocket flanked by serine residues between their N-terminal domains. Ivermectin directly binds this pocket to inhibit MAPKAP2-mediated HSP27 phosphorylation and depolymerization, thereby blocking HSP27-regulated survival signaling and client-oncoprotein interactions. Ivermectin potentiated activity of anti–androgen receptor and anti-EGFR drugs in prostate and EGFR/HER2-driven tumor models, respectively, identifying a repurposing approach for cotargeting stress-adaptive responses to overcome resistance to inhibitors of oncogenic pathway signaling.

To see the Info - Click on the Link Below:

Link : "Ivermectin"
or Go To
http://rvaprostatecancersupport.org/PDF/8 24 21 Nappi-2019-Ivermectin.pdf

Us Too Warriors,
Presdnisone is prescribed with Zytiga PCa treatment at 10mg/d in advanced cancer can Cause heart damage

Us Too Warriors, friends and family, I had a drug dose reaction to two rounds (10 days each hi dose 200 mg/d doxycycline) for two tick bits within 8 days of each other (to prevent Lyme disease as I had red bullseye from a bit). The high dose Doxycycline caused the roof of my mouth to break out in blisters making it hard to eat/swallow. One of my dental friends recommended a short course of prednisone and "miracle compounded mouthwash" that my dental son prescribed. It has worked well to reduce the blistering in four days.

I have learned a lot about Doxycycline and prednisone in the process that which I'm going to relay to you below.

1. I have used low dose doxycycline (100mg/day) for 14 years to prevent MMPS from the cancer cells from promoting Metastasis so I already had doxycycline primed in my system before I started on the higher doses.
2. Doxycycline reduces Tau and amyloid plaques in the brain to keep the brain better functioning against Alzheimer's.
3. Prednisone raises the heart rate in my case low thirties for me (BPM) to 55 to 65 BPM. which is the normal range.
4. Prednisone makes afib conversion better by stopping inflammation of the heart muscle.
5. If you are on high doses of prednisone for any period of time you will have withdrawal symptoms if you do not taper off slowly.
6. My prescription for the blisters had built in taper off = 4 days at 60mg; 4days at 40 mg and 4days at 20 mg.
7. Prednisone causes heart disease even at 5 mg/day (74% increase) if used for any period of time. Higher the dose the worse the heart is made.
8. See the attached paper for more info below

Read below for more information.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Prednisone"
or Go To
https://www.sciencedaily.com/releases/2020/12/201203144217.htm

Us Too Warriors,
Cognitive Decline Associated With Anesthesia and Surgery in Older Patients

At 54 years old my PCa surgery caused me to lose my spatial map in my head for driving in Richmond for at least 5 years. I do not know if I relearned it by driving or if it came back on its own? But now I can recall in my mind the street connections to get me to a place I know in my mind.

So I believe Surgery & anesthetics can hurt your mind so it is a side effect you need to be aware of if your doctors recommend Surgery.

For my last Melanoma surgery that required surgery under my arm to remove a lymph node to prove I was cancer free; I got my doctor with local lidocaine which she agreed to as she had done a surgery like that for a pregnant woman.
Read below for more information.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Cognitive Decline"
or Go To
http://rvaprostatecancersupport.org/PDF/8 9 21 jama.pdf

Us Too Warriors,
Adjuvant Treatment to many types of cancer, LEF protocol attachment for your Info

Over the years it has been obvious for selves and families we need to be able to defend against many health issues and cancers besides Prostate cancer. I have had 5 skin cancers (2 were melanomas) removed in the last five years and one on my wife. I have already helped my family in their treatment of two Prostate cancers (both brothers) kidney cancer and lung cancer. Recently, a family member who ate too many hot peppers has been diagnosed with stomach cancer, a common problem in Mexico. With that in mind I have attached a Life Extension protocol below that discusses many adjuvant treatments to make understanding and treating many of the cancers we are subject to as well as prostate cancer possible. I hope this will make you better able or your family better able to defend against them.

Read below for more information.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Adjuvant Treatment"
or Go To
https://www.lifeextension.com/protocols/cancer/cancer-adjuvant-therapy

******************************************
Us Too Warriors,
Covid long haulers are tied to reactivation of Latent Epstein-Barr Virus (95 % of adults have latent EBV in their blood)

Black seed Cumin {Nigella (N. sativa)} by Swanson Inc , I discussed as a source of Thymoquinone to promote the immune system and fight Prostate cancer at one of our Us Too meetings about 5 years ago. Well, now it is being tested by NIH to fight long term Covid in a Phase 1 trial. This is a particular concern for me as my wife as I believe she got Fibromyalgia from a bout with EBV! EBV is also the cause of mononucleosis = the Kissing disease. Remember 95 % of people have this latent virus in their body so if you have weak immune system it is likely to reactivate if you get covid - I recommend that you start taking Black cumin seeds as a preventative.
Read below for more information.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Black Seed"
or Go To
http://rvaprostatecancersupport.org/PDF/8 4 21 Taborsky-2012.pdf

*

Link : "Epstein-Barr-virus"
or Go To
http://rvaprostatecancersupport.org/PDF/8 4 21 Epstein-Barr-virus.pdf

****************************************
Us Too Warriors,
Discussion of Focal therapy for PCa for local PCa

If you have MRI or other imaging biopsy that shows your cancer is localized/small, not high gleason and not near an area hard to treat you may be a candidate for focal therapy.
Read below for more information.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Focal Therapy"
or Go To
http://rvaprostatecancersupport.org/PDF/8 2 21.pdf

Us Too Warriors,
Paper describing benefits of Vitamins K1 and K2 for many health issues including PCa

Read below and consider if you should not add vitamin K2 supplements to your armamentarium. I learned of the value of Vitamin K in my research career for jaw bone health and its use to prevent osteoporosis. Presently I am recommending its supplementation in children to VCU Pedontics department to prevent tooth decay in children. We have already shown the benefit of vitamin D3 to prevent tooth decay in children in a clinical study at VCU. Vitamin D3 supplementation increases gut calcium absorption and Vitamin K2 sends the Calcium to the bones thus keeping it out of blood vessels (preventing hardening of the arteries).
Read below for more information.

Best
Peter

To see the Info - Click on the Link Below:

Link : "K2"
or Go To
http://rvaprostatecancersupport.org/PDF/7 27 21 Vit K.pdf

Us Too Warriors,
Tetenas and diptheria and petussas vaccine can boost imuune system
improves Immune system and reduces Covid side effects by 50%

I recently got Tetanus and diphtheria and pertussis Vaccine at Patient 1st as a way to boost my Covid Vaccine as it is about 6months from my 2nd Pfizer shot for Covid-19. I went there to get doxycycline for possible tick bite as I had red bulls eye on my leg characteristic of the bite. I normally take 100mg pill per day to slow PCa metastasis, but Two 100 mg pills a day are the treatment for Tick bites. I have found 6 ticks crawling on my body in the last few weeks but none had bite thru the skin that I knew of.
Read below for more information.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Old Vaccine"
or Go To
http://rvaprostatecancersupport.org/PDF/7 24 21 Prior-vaccination.pdf

Link : "Old Vaccine Article"
or Go To
https://www.medicalnewstoday.com/articles/old-vaccines-for-covid-19-tetanus-diphtheria-show-promise

Us Too Warriors,
New drug for PCa & Breast cancer to breakdown AR-V7 short androgen = receptor activators ( PCa on all the time= Anti adrogens don'twork)

You have seen emails from me about developing worm Pill=Nicolaosamide to break down AR-V7. I have found out this niclosamide is not very soluble so it has to be micronized to size of about 1 micron to make it work in the body in a "Jet Mill" I am waiting for delivery of Niclosamide from Germany but I think it is being held up by the flooding there. Also I may have to get a Jet Mill to make it work??

In the meantime, I found the paper attached (by one of the researchers who tested Niclosamide) on a new drug (ARVib) being developed to block AR-V7.

Pfizer is investing 1 billion dollars to bring it to market in partnership with a small drug company ARVINAS that developed it. They are aiming to tackle breast cancer first so I expect it will be 5 years at least before it is available for PCa. So for now I will be pursuing niclosamide.

Best
Peter

To see the Info - Click on the Link Below:

Link : "New Drug"
or Go To
http://rvaprostatecancersupport.org/PDF/7 23 21 Liu-2021.pdf

Us Too Warriors,
Niclosamine and Indomethacin May make Anti-androgens like Casodex, Enzalutamide work after they start to fail do to AV-7

This is a treatment I am investigating as my casodex is starting to fail after 3 years. I will start it within a month and may know how it is working by the fall. See abstract and patent that follow. Wish me well and I hope it can help others in our group.
Abstract:

Enzalutamide and Indomethacin in Treating Patients with Recurrent or Metastatic Castration-Resistant Prostate Cancer

This phase I / II trial studies the side effects of enzalutamide and indomethacin and to see how well they work in treating patients with prostate cancer that does not respond to treatment with hormones despite surgical removal of testes (castration-resistant), has come back (recurrent), or has spread from where it started to other places in the body (metastatic). Androgens can cause the growth of prostate cancer cells. Indomethacin is a non-steroidal anti- inflammatory drug that has been found to block one of the signals that enhance prostate cancer cell growth. Hormone therapy using enzalutamide and indomethacin may fight prostate cancer by lowering the amount of androgen the body makes and / or blocking the use of androgen by the tumor cells.

Location: University of California Davis Comprehensive Cancer Center, Sacramento.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Patent"
or Go To
http://rvaprostatecancersupport.org/PDF/7 12 21 Patent Application.pdf

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Us Too Warriors,
Niclosamide and Bicalutamide Combination Treatment Overcomes Enzalutamide
and Bicalutamide-Resistant Prostate Cancer

Abstract:

Activation of the androgen receptor (AR) and its splice variants is linked to advanced prostate cancer and drives resistance to antiandrogens. The roles of AR and AR variants in the development of resistance to androgen deprivation therapy (ADT) and bicalutamide treatment, however, are still incompletely understood. To determine whether AR variants play a role in bicalutamide resistance, we developed bicalutamide-resistant LNCaP cells (LNCaP-BicR) and found that these resistant cells express significantly increased levels of AR variants, particularly AR-V7, both at the mRNA and protein levels. Exogenous expression of AR-V7 in bicalutamide-sensitive LNCaP cells confers resistance to bicalutamide treatment. Knockdown of AR-V7 in bicalutamide- and enzalutamide-resistant CWR22Rv1, enzalutamide-resistant C4- 2B (C4-2B MDVR), and LNCaP-BicR cells reversed bicalutamide resistance. Niclosamide, a potent inhibitor of AR variants, significantly enhanced bicalutamide treatment. Niclosamide and bicalutamide combination treatment not only suppressed AR and AR variants expression and inhibited their recruitment to the PSA promoter, but also significantly induced apoptosis in bicalutamide- and enzalutamide-resistant CWR22Rv1 and C4-2B MDVR cells. In addition, combination of niclosamide with bicalutamide inhibited the growth of enzalutamide-resistant tumors. In summary, our results demonstrate that AR variants, particularly AR-V7, drive bicalutamide resistance and that targeting AR-V7 with niclosamide can resensitize bicalutamide-resistant cells to bicalutamide treatment. Furthermore, combination of niclosamide with bicalutamide inhibits enzalutamide resistant tumor growth, suggesting that the combination of niclosamide and bicalutamide could be a potential cost-effective strategy to treat advanced prostate cancer i

Best
Peter

To see the Info - Click on the Link Below:

Link : "Niclosamide and Bicalutamide"
or Go To
http://rvaprostatecancersupport.org/PDF/7 9 21 Niclosamide-and-bicalutamide-combin.pdf

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Us Too Warriors,
SBRT supports rariation in 3 to 4 metastasis in many cancers

Abstract below for your information. it used a range of radiation levels from 30 gray total in 3 application to 50 grey total in 5 applications

Best
Peter

Abstract:

Importance: Stereotactic body radiotherapy (SBRT) for oligometastases is hypothesized to improve survival and is increasingly used. Little evidence supports its safe use to treat patients with multiple metastases.

Objective: To establish safety of SBRT dose schedules in patients with 3 to 4 metastases or 2 metastases in close proximity to each other.

To see the Info - Click on the Link Below:

Link : "SBRT"
or Go To
https://pubmed.ncbi.nlm.nih.gov/33885704/

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Us Too Warriors,
CBD effects apoptosis in all 4 PCa cell lines -- significantly enhanced the anti‐cancer effects of bicalutamide

The results obtained can be summarized as follows. Firstly, cannabinoids and BDS reduced PCC viability with higher potency and efficacy in the absence of serum proteins, and regardless of the presence of hormones in the medium and of the androgen dependency of the PCC line under study. With serum deprivation, CBD was the most efficacious compound in three out of the four cell lines investigated. These results are in full agreement with previous observations in glioma cells (Jacobsson et al., 2000). Secondly,amongst all the possible known cannabinoid targets investigated, only TRPM8 channels, when present (as in LNCaP cells), seemed to mediate, and only in part, the effect of CBD. Finally, under certain dosing conditions, CBD produced synergistic effects with docetaxel and/or bicalutamide in DU‐145 and/or LNCaP cells.

Best
Peter

To see the Info - Click on the Link Below:

Link : "CBD"
or Go To
http://rvaprostatecancersupport.org/PDF/6 23 21 De-petrocellis.pdf

*******************************************
Us Too Warriors,
Vitamin K2 supplementation to fight PCa, Heart disease and chronic kidney disease

I am just reordering My " Mega Vitamin K2 supplement" from Lef.org . I am recommending it to my brothers both for PCa and one with chronic Kidney disease and the other with heart related carotid artery calcification surgery for 80% blockage. Read the attachments below as it is hard to get enough Vitamin k2 from leafy green vegetables for what we need as we Age.

I am working with the VCU pedodontics department to see if I can interest them in a clinical trial of Vitamin K2 in young children as I have in the past done with vitamin D3 as a way to prevent cavities in young children. Think about your GrandChildren for Vitamins D3 & K2.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Vitamin K2"
or Go To
http://rvaprostatecancersupport.org/PDF/6 20 21 Juanola-falgarona-2014-Dietary-intake-of-vitamin-k-is-inve-1.pdf
*
Vitamin K role in mineral and bone disorder of chronic kidney disease

Link : "Vitamin K2 - Kidney Disease"
or Go To
https://pubmed.ncbi.nlm.nih.gov/31836502/

*********************************************
Us Too Warriors,
Selective androgen receptor modulators activate the canonical prostate
cancer androgen receptor program and repress cancer growth

Introduction

Prostate secretory epithelial cells and neoplastic derivatives are dependent on the androgen receptor (AR) to regulate differentiation, metabolism, growth, and survival (1–3). Currently, inhibition of AR signaling using androgen deprivation therapy (ADT), which involves various means of depriving tumors of the AR ligands testosterone (T) and dihydrotestosterone (DHT), is the predominant therapeutic approach for treating metastatic prostate cancer (mPC) (4). Although ADT is highly effective initially, mPC progresses to metastatic castration-resistant prostate cancer (mCPRC) within 1 to 3 years (5)

Best
Peter

To see the Rest of the Info - Click on the Link Below:

Link : "Modulators"
or Go To
http://rvaprostatecancersupport.org/PDF/6 20 21 Nyquist-2021-Selective-androgen-receptor-modulat (1).pdf

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Us Too Warriors,
Selective androgen receptor modulators- SARMs look very promising as new PCa treatment -available without a prescription

This SARMs use for PCa is new to me as of today and it has been Clinically tested at U. of Washington. I am ordering some online to try today.

It is used by weight lifters and is good to build muscle, fat loss and bone health as well as prevent muscle wasting (cachexia) from cancer.

It has positive benefits for these conditions as opposed to these negative conditions produced by Lupron ADT.

Best
Peter

To see the Info - Click on the Link Below:

Link : "SARMs"
or Go To
http://rvaprostatecancersupport.org/PDF/6 18 21 SARM.pdf

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Us Too Warriors,
PSMA imaging test now availble in Fort Lauderdale

This test recently approved for imaging advanced cancer. See below.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Pylarify"
or Go To
http://rvaprostatecancersupport.org/PDF/6 18 21 Pylarify.pdf

Us Too Warriors,
Melatonin and Doxycycline Blog attached to prevent/slow PCa cell migration and Mets

Read the blog below to see how to slow/prevent PCa cell migration to new organs called the EMT progression/transition. In the E=Epithilial stage the cells bind together but M=Mesenchymal where the cells do not bind together and they can float/migrate off to do damage in other organs.

I use 50 mg of melatonin at night at bedtime and if I wake I take 20 more. I take 100mg of doxycycline which I know from research in dental diseases ( tooth decay and periodontal infections) are prevented or reduced by doxycycline by preventing Matrix Metalloproteinases (MMPs) from breaking down collagen in the periodontal ligament fixing our tooth roots in to our jaw bone. When the MMPs break down the ligaments the roots come loose from the jaw and fall out. Also, the collagen in the dentin under the enamel of our teeth, is attacked by decay's MMPs turning it into a mushy of gelatin at the decay site. MMPs are shot out of invadopodia spikes on our cancer cells to drill through the extracellular matrix holding the cells in place so they can migrate to form mets in other organs and bones to do damage. You can see my dental research primed me to understand cancers ways of action,

Please read the following to inform yourself:

Best
Peter

To see the Blog - Click on the Link Below:

Link : "Blog"
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/146255838/melatonin-suppressed-pca-cells-migration-and-invasion-by-blocking-emt-epithelial-mesenchymal-transition

Us Too Warriors,
Paper comparing 2nd & 3rd level Antiandrogens Apalutamide, Enzalutamide, and Darolutamide Clinicla trials nmCastration resistant PCa

The paper attached below describes the side effects found in the Clinical trials and the effectiveness in treating nmCastration resistant PCa.

My brother had to stop Enzalutamide as the fatigue was so great it interfered with his mobility/walking. This fatigue problem was also pointed out by the clinical trial. He is trying a short course of Casodex as monotherapy, a level 1 antiandrogen, that has worked for me going on 3 1/2 years. If and when Casodex fails for me I would consider Darolutamide as it has the best side effect profile except Afib. See the attached paper to inform yourself.

Best
Peter

To Go to the Website - Click on the Link Below:

Link : "Antiandrogens"
or Go To
http://rvaprostatecancersupport.org/PDF/6 3 21 s41391-020-00310-3.pdf"

Us Too Warriors,
Too back up your Glucose restriction by lowering Glutamine and Glutamate with supplements and to slow PCa growth

Check out the website below for more information:

Here are 10 foods that can block glutaminase in research. I take 3 pills per day of the items marked with @

EGCG (Green tea)@
Curcumin (Turmeric root)@
Lycopene (Tomatoes)@
Ursolic Acid (Holy basil, pistachio nuts, Rosemary)@
Resveratrol (Red grape skins)@
Honokiol, magnol (Magnolia Bark Extract)@
Graviola (Soursop)
Sulforaphane (Sprouting seeds)@
Valerian
Withanolide (Ashwagandha)@

Best
Peter

To Go to the Wewbsite - Click on the Link Below:

Link : "Foods"
or Go To
https://www.canceractive.com/article/glutamine-glutamate-diet-and-cancer

Us Too Warriors,
STOP FIGHTING CANCER and Start Treating the Cause

The book copied below has many suggestions for treating prostate cancer inflammation and antioxidants that I have used for years. Give it a look and see if it can help in your treatment. It was sent to me by the Doctor Wife of one of our members. we hope you find it helpful.

Best
Peter

To Go to the Information - Click on the Link Below:

Link : "Treating the Cause"
or Go To
http://rvaprostatecancersupport.org/PDF/5 24 21 Stop-Fighting-Cancer-3rd-Edition-compressed.pdf

Us Too Warriors,
My Personal "trial" of Cyclic Testosterone Therapy

This blog describes a brave man who has blazed a path for others by working with his Doctors. It is early in the game but the results look very promising. This is not BAT=Bipolar Androgen therapy because no ADT is Used. It should be called " Monopolar Testosterone therapy".

Best
Peter

To Go to the Information - Click on the Link Below:

Link : "Cyclic"
or Go To
http://rvaprostatecancersupport.org/PDF/5 20 21 My Personal.pdf

Us Too Warriors,
My Personal "trial" of Cyclic Testosterone Therapy

This blog describes a brave man who has blazed a path for others by working with his Doctors. It is early in the game but the results look very promising. This is not BAT=Bipolar Androgen therapy because no ADT is Used. It should be called " Monopolar Testosterone therapy".

Best
Peter

To Go to the Information - Click on the Link Below:

Link : "Cyclic"
or Go To
http://rvaprostatecancersupport.org/PDF/5 20 21 My Personal.pdf

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Us Too Warriors,
SBRT - CyberKnife

A member who lives near me will be using SBRT CyberKnife therapy to treat his 3+4 diagnosed PCa soon. I am attaching some Googled information on Herbal supplements that may reduce the side effects and may make it more effective. He will be going to Northern Virginia for treatment(~5 days) and it is also available through Dr. Cuttino at Henrico Doctors.

From what I read the Supplements which may make SBRT more effective, reduce radiation side effects and Online for purchase are: biocurcumin,69–71 resveratrol,72–74 dihydroartemisinin75–77. But most Especially Nitric Oxide like the Snap Inc's Nitric Oxide Booster and LEF's " NitroVasc Boost". These are ones that you can buy onLine. Nitric Oxide acts like Oxygen when radiated and increases blood flow so the oxygen poor regions of the cancer can be damaged by the radiation which are areas where the cancer may be hard to kill with radiation!!!

Best
Peter

Abstract:
Radiotherapy (RT) is a cancer treatment that uses high doses of radiation to kill cancer cells and shrink tumors. Although great success has been achieved on radiotherapy, there is still an intractable challenge to enhance radiation damage to tumor tissue and reduce side effects to healthy tissue. Radiosensitizers are chemicals or pharmaceutical agents that can enhance the killing effect on tumor cells by accelerating DNA damage and producing free radicals indirectly. In most cases, radiosensitizers have less effect on normal tissues. In recent years, several strategies have been exploited to develop radiosensitizers that are highly effective and have low toxicity. In this review, we first summarized the applications of radiosensitizers including small molecules, macromolecules, and nanomaterials, especially those that have been used in clinical trials. Second, the development states of radiosensitizers and the possible mechanisms to improve radiosensitizers sensibility are reviewed. Third, the challenges and prospects for clinical translation of radiosensitizers in oncotherapy are presented.

To Go to the Information - Click on the Link Below:

Link : "CyberKnife"
or Go To
http://rvaprostatecancersupport.org/PDF/5 19 21 ijn-290438-application-of-radiosensitizers-i.pdf

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Us Too Warriors,
The BAD Doctors of The United States (ANTI)Preventive Services Task Force (USPSTF) is a government-funded group

You need to read the below article and send to family and friends. The red text additions are mine.

The BAD Doctors of The United States (ANTI)Preventive Services Task Force (USPSTF) is a government-funded group that claims:
Cross-section of bladder and prostate affected by cancer “to improve (Harm) the health of all Americans by making (False) evidence-based recommendations about clinical preventive services.” recommended against PSA test for PCa in 2012. This resulted in the number of Annual PSA tests dropping from 50% of Men to 30% of men and the age for testing was raised to 55years old to start while families with a history of PCa should start at 40 year. The earlier you Dx Prostate cancer the more likely it is to be dangerous!!

Read and send it to your Sons and Son-in-laws and friends.

Best
Peter

To Go to the Information - Click on the Link Below:

Link : "Bad"
or Go To
http://rvaprostatecancersupport.org/PDF/5 18 21 Bad.pdf

Us Too Warriors,
Relation of TMPRSS2-ERG Fusion Mutation in PCa and Covid 19 is not clear but many interactions seem possible

See the Attached paper on how TMPRSS2 gene may relate to your cancer and Covid-19.??

I learn the following things that apply to between 40 % and 70% of PCa which affect men with TMPRSS2 -ERG PCa:

1. As TMPRSS2-ERG fusion prostate cancer advances it is likely to trigger worse mutations of: P53 negative, Pten negative and Brca 1 & 2 mutations.
2. There is less TMPRSS@-ERG fusion mutation production in the central zone of the prostate than in the peripheral zone of the prostate so growth for men with that area of the prostate should be much slower. My Brother David's cancer is in that area. I and my Brother Don's were at the periphery. David with the help of some of my supplements was not diagnosed with PCa until 26 & 27 years after Me and Don. David is on active surveillance with slow growing PSA with another MRI biopsy in another year - 3+ years from the first.
3. Vcap cell line is TMPRSS2-ERG fusion gene positive and LNCAP cell line is TMPRSS2-ERG fusion gene negative.
4. TMPRSS2-ERG fusion Prostate cancer genes are usually very high in Vitamin D3 receptors-so vitamin D supplement may be a good treatment.
5. TMPRSS2 is used to get the Covid virus into Our body cells to affect the lung etc.
Best
Peter

Abstract:
Members of Coronaviridae family have been the source of respiratory illnesses. The outbreak of SARS-CoV-2 that produced a severe lung disease in afflicted patients in China and other countries was the reason for the incredible attention paid toward this viral infection. It is known that SARS-CoV-2 is dependent on TMPRSS2 activity for entrance and subsequent infection of the host cells and TMPRSS2 is a host cell molecule that is important for the spread of viruses such as coronaviruses.

Different factors can increase the risk of prostate cancer, including older age, a family history of the disease. Androgen receptor (AR) initiates a transcriptional cascade which plays a serious role in both normal and malignant prostate tissues. TMPRSS2 protein is highly expressed in prostate secretory epithelial cells, and its expression is dependent on androgen signals. One of the molecular signs of prostate cancer is TMPRSS2-ERG gene fusion. In TMPRSS2-ERG-positive prostate cancers different patterns of changed gene expression can be detected. The possible molecular relation between fusion positive prostate cancer patients and the increased risk of lethal respiratory viral infections especially SARS-CoV-2 can candidate TMPRSS2 as an attractive drug target. The studies show that some molecules such as nicotinamide, PARP1, ETS and IL-1R can be studied deeper in order to control SARS-CoV-2 infection especially in prostate cancer patients.

This review attempts to investigate the possible relation between the gene expression pattern that is produced through TMPRSS2-ERG fusion positive prostate cancer and the possible influence of these fluctuations on the pathogenesis and development of viral infections such as SARS-CoV-2.

To Go to the Information - Click on the Link Below:

Link : "TMPRSS2-ERG"
or Go To
http://rvaprostatecancersupport.org/PDF/5 16 21 main (1).pdf

Us Too Warriors,
My experience with low dose Doxycycline (100 mg/day) fighting Mets from PCa and Periodontal Disease and now Covid

I have been taking low dose doxycycline for periodontal disease for 14 years to prevent/slow PCa - the mets which are allowed to escape into the body by invadopodia spikes on cancer cells that shoot out Matrix Metallo Proteins that breakdown the extracellular protein collagen that helps to encapsulate the cancer so it is harder to escape to a blood vessel to damage other body organs as a metastasis. These Matrix Metallo Proteins (MMPs) also attack the periodontal ligament that holds teeth to bone to keep them fixed in place. Periodontal infections release MMPs to break down the ligament so that the teeth are loosened and fall out. These same MMPs attack the Dentin of the tooth and turn it into the mush of tooth decay.These same MMPs attack the lungs during Covid and cause blood Clots that kill.

With the use of low dose doxycycline, my periodontal tissue has been excellent - much improved compared to earlier years - no bleeding on brushing, I have all my teeth at 81yrs with only one crown for a cracked tooth. My research in this area over the years has paid dividends for my teeth, cancer and Covid. I was able to make improved bonding treatments for use at the VCU dental school and throughout the world.
Best
Peter

Abstract:
This review describes the relationship between dentin collagen hybrid bond layer degradation and the Matrix Metalloproteinases (MMPs) after their release by acid etch and rinse adhesives and self etching bonding adhesives that can reduce the bond stability over time. MMP-2, MMP-8 and MMP-9 are indicated as the active proteases that breakdown the collagen fibrils in the hybrid bond layer. Phosphoric acid in the acid etch and rinse bonding process and acid primers in the self etch process are implicated in the release of these proteases and their activation by several non-collagen proteins also released from dentin by the etching. MMPs are released in saliva by salivary glands, by cells in the gingival crevices to crevicular fluid and by pulpal odontoblasts cells to the dentinal fluids. These sources may affect the hybrid layer also. Evidence of the bond strength deterioration over time and the ability of Chlorhexidine to prevent bond deterioration by inhibiting MMP action are discussed. Dentin Bonding procedure utilizing Chlorhexidine for different application times and concentrations are being developed. The application of 2% Chlorhexidine to the phosphoric acid etch surface after rinsing off the acid is the only procedure that has been clinically tested for a longer period of time and shown to prevent bond strength degradation so far. The adoption of this procedure is recommended as means of improving bond stability at this time.

To Go to the Information - Click on the Link Below:

Link : "Periodontal Disease"
or Go To
http://rvaprostatecancersupport.org/PDF/5 14 21 TODENTJ-4-147.pdf

Us Too Warriors,
Aspirin Use / Prostate Cancer among African-American Men in the Southern Community Cohort Study

Prospective SCCS data suggest that aspirin use may help prevent lethal prostate cancer among this high-risk group of men
Best
Peter

To Go to the Information - Click on the Link Below:

Link : "Aspirin"
or Go To
http://rvaprostatecancersupport.org/PDF/5 8 21 Cohort study of aspirin use among African Americans.pdf
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Us Too Warriors,
Green tea and Mung Bean Turn Off the Cytokine Switch

A biochemical “switch” that turns on many of the chronic diseases of aging has been uncovered. Known as HMGB1, this molecule triggers the release of cytokines—a collection of chemical signals—that generate inflammation in your body. In a hospital setting, researchers have shown that mung bean seed coat and green tea extract counteract HMGB1, safely quelling acute inflammation before it becomes chronic.
Best
Peter

To Go to the Information - Click on the Link Below:

Link : "Cytokine Switch"
or Go To
https://www.lifeextension.com/magazine/2014/1/turn-off-the-cytokine-switch
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Us Too Warriors,
Vitamin K2 is good for heart, brain and ADT lupron treatment which lowers K2 in PCa patients
that will cause Osteoporosis in PCa and doubles the risk of heart attacks.

There are many benefits of Vitamin K2 see below. (Especially if you have APOE4 genes Alzheimer's genes like my family)

Best
Peter

To Go to the Information - Click on the Links Below:

Link 1 : "ADT"
or Go To
http://rvaprostatecancersupport.org/PDF/4 15 21 androgen-deprivation-therapy-induces-vitamin.pdf

Link 2 : "Vit K2"
or Go To
https://lundberginstitute.org/surprise-vitamin-k2-and-cancer/

Link 3 : "Managing prostate cancer metastasis using vitamin k2"
or Go To
https://grantome.com/grant/NIH/R21-CA184646-01A1

Link 4 : "Vit K2 & Alzheimer’s disease"
or Go To
https://www.alzheimers.net/2014-07-09-vitamin-k-alzheimers-prevention
*
Us Too Warriors,
Long-term Efficacy and Safety of Enzalutamide Monotherapy

Long-term Efficacy and Safety of Enzalutamide Monotherapy in Hormone-naïve Prostate Cancer: 1- and 2-Year Open-label Follow-up Results
Best
Peter

Abstract - Background

Enzalutamide is an androgen receptor inhibitor with a demonstrated overall survival benefit in metastatic castration-resistant prostate cancer. A phase 2 study of enzalutamide monotherapy in patients with hormone-naïve prostate cancer (HNPC) showed a high response rate for the prespecified primary endpoint (ie, prostate-specific antigen [PSA] response at week 25), regardless of metastases at baseline, and favorable tolerability.

To Go to the Information - Click on the Links Below:

Link 1 : "Monotherapy"
or Go To
https://www.sciencedirect.com/science/article/pii/S0302283815000706#:~:text=A%20phase%202%20study%20of%20enzalutamide%20monotherapy%20in,regardless%20of%20metastases%20at%20baseline%2C%20and%20favorable%20tolerability.
*
Us Too Warriors,
Nitrosative stress in cancer therapy

Paper below is on NO pathways in Cancer
Best
Peter

To Go to the Information - Click on the Links Below:

Link 1 : "NO pathways"
or Go To
http://rvaprostatecancersupport.org/PDF/4 5 21 994103 (1)-1.pdf
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Us Too Warriors,
Lowering Cholesterol/PCa growth

I have been using prescription statins for about a year. My doctor prescribed Pravastatin (Hydrophilic molecule) which is one of the two best, The other best statin is Pitavastatin (Lipophilic Molecule) See the attached paper. Also, I have been taking Red Rice Yeast supplement, Swanson Inc., a natural source of Atorvastatin for years. I am going to see if my GP Doctor will also prescribe a low dose of Pitavastatin. My dental research experience suggests that using both hydrophobic and hydrophilic statin will be more effective in lowering Cholesterol/PCa growth. Metformin which I have used for 3+ years makes statins more effective! Best Peter A 2nd Paper below discusses how Statins work in PCa,
Best
Peter

To Go to the Information - Click on the Links Below:

Link 1 : "Cholesterol 1"
or Go To
http://rvaprostatecancersupport.org/PDF/4 5 21 vc995759-1.pdf

Link 2 : "Cholesterol 2"
or Go To
https://pubmed.ncbi.nlm.nih.gov/32694690/
*
Us Too Warriors,
Phytoestrogen use in Advanced Cancer that maintain the Estrogen receptor
beta active KEEPs EGFR out of the Nucleus to slow PCa

This just published paper describes the need to use phytoestrogens with Finasteride(but probably also Avodart??) in Advanced Cancer to maintain the Estrogen receptor beta active that KEEPs EGFR out of the Nucleus to slow PCa. I have been taking Phytoestrogens with Finasteride and Avodart for years (21years) for years. See Paper attached my email address below!

This attached Paper seems closely tied to the email I sent you a few days ago titled : RVA Us Too- ESTROGEN RECEPTOR beta Inhibits PCa/CRPC forming on ADT!!!!
Best
Peter

To Go to the Information - Click on the Link Below:

Link : "Phytoestrogen"
or Go To
http://rvaprostatecancersupport.org/PDF/4 1 21 Wu-2021-Estrogen-receptor--and-treatment-wi.pdf
*********************************************
Us Too Warriors,
"BR-DIM" supplement is highlighted as a way to prevent or reverse CRPC especially of enzalutamide resistant

"BR-DIM" supplement is derived from Cruciferous vegetables which we all know are good for fighting PCa. Well finally some clinical trial results are published and attached below. It appears to inhibit the Androgen receptor from going to the nucleus which grows the cancer and keeps short length androgen receptors like ARv-7 away which is on all the time and does not need testosterone to grow PCa..

"BR-DIM" is described as an Androgen receptor Antagonist which is what Enzalutamide and Casodex (which Iuse and it is expected to make them act better and longer. I have been using DIM-plus thru Swanson but I will explore Amazon to see what's available.
Best
Peter

To Go to the Information - Click on the Links Below:

Link 1: "Link 1"
or Go To
http://rvaprostatecancersupport.org/PDF/4 1 21 41598_2020_Article_80519-1.pdf
*
Link 2: "Link 2"
or Go To
http://rvaprostatecancersupport.org/PDF/4 1 21 ajtr0008-0166-1.pdf
*
Link 3: "Link 3"
or Go To
http://rvaprostatecancersupport.org/PDF/4 1 21 4439307.pdf
****************************************************************************************
Us Too Warriors,
ESTOGEN RECEPTOR beta Inhibits PCa/CRPC forming on ADT!!!!

I have known that increasing ESTROGEN RECEPTOR beta and decreasing ESTROGEN RECEPTOR alpha was beneficial in SLOWING PCa.

But a Paper came out today that shows phytoestrogen like Apigenin phytoestrogen, Soy phytoestrogen and Tectogenin phytoestrogen and VPA Drug can increase ESTROGEN RECEPTOR beta to fight CRPC forming on ADT treatment in patients. SEE papers attached.
Best
Peter

To Go to the Information - Click on the Links Below:

Link 1: "Link 1"
or Go To
http://rvaprostatecancersupport.org/PDF/3 29 21 Estrogen.pdf
*
Link 2: "Link 2"
or Go To
http://rvaprostatecancersupport.org/PDF/3 29 21 Estrogen 2.pdf
*****************************************************************************************
Us Too Warriors,
P53 mutation paper and effects in different cancers

Garufi et al., found that capsaicin, the major constituent of peppers, induced mutant p53 degradation and restored wild type p53 functions such as DNA binding and transactivation of target genes [11]. Furthermore, in combination with chemotherapeutic agents, capsaicin induced cell death suggesting that capsaicin-induced p53 reactivation may improve mutp53-carrying cancer cell response to chemotherapy [116].
See below
Best
Peter

To Go to the Information - Click on the Links Below:

Link 1: "Link 1"
or Go To
http://rvaprostatecancersupport.org/PDF/3 27 21 13046_2018_Article_705.pdf
*
Link 2: "Link 2"
or Go To
http://rvaprostatecancersupport.org/PDF/3 27 21 2460353 (1).pdf
*
Link 3 : "Link 3"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228035/
*
Link 4 Vegetables as Good Source on how to fight P53 : "Link 4"
or Go To
https://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/isothiocyanates

******************************************************************************************
Us Too Warriors,
More Glutamine and Glutamate reduction and Diet to fight Cancer

Check out these websites to lower your Glutamine/Glutamate by a spicy diet and Supplements.

I am taking 9 of the 10 supplements to lower Glutamate in the second website. The only one I am not taking is Valerian.
See below
Best
Peter

Anti-Cancer Strategies: Inhibit Glutamine

To Go to the Web pages - Click on the Links Below:

Link 1 : "Strategies 1"
or Go To
hhttps://eatandbeatcancer.com/2017/06/24/anti-cancer-strategies-inhibit-glutamine/
*
Link 2 : "Strategies 2"
or Go To
https://www.canceractive.com/article/glutamine-glutamate-diet-and-cancer

****
Us Too Warriors,
Promising research work at Duke on Glutamine suppression as an alternative to ADT

This sounds interesting. I'm hopeful that it turns out to be a legit therapy.
See below
Best
Peter

The team of Duke Cancer Institute researchers used that finding to propose a treatment strategy that eliminates the need to inhibit the androgen receptor completely. Their goal is to directly target the tumor’s preferred source of fuel – an amino acid called glutamine.

To Go to the Web page - Click on the Link Below:

Link : "Duke"
or Go To
https://corporate.dukehealth.org/news/prostate-cancer-uses-metabolic-switch-thrive-after-hormone-therapy

Us Too Warriors,
FEMA will provide $7000 funeral expenses startin in April 2021 for anyone who die from Covid after Jan 2020

Us Too men, I hope your families have survived this Virus and are getting shots if they have not already gotten them.
See below
Best
Peter

To Go to the FEMA Web page - Click on the Link Below:

Link : "FEMA"
or Go To
https://www.fema.gov/disasters/coronavirus/economic/funeral-assistance

Us Too Warriors,
Radioligand shows benefit over chemotherapy in prostate cancer

PSMA (prostate-specific membrane antigen) -targeted radiopharmaceutical therapy could be more effective and better tolerated than current chemotherapy in patients with metastatic castration-resistant prostate cancer (mCRPC), according to a recent trial.

The Australian study published in the Lancet, compared Lutetium-177 [177Lu]Lu-PSMA-617 (intravenously every six weeks for up to six cycles) with cabazitaxel (20 mg/m2 intravenously every three weeks for up to ten cycles) in 183 men with mCRPC.
See below
Best
Peter

To Read the Paper - Click on the Link Below:

Link : "Radioligand"
or Go To
https://wchh.onlinelibrary.wiley.com/do/10.1002/tre.0030031

Us Too Warriors,
Relation between Nitric Oxide Supplementation, Hormones and TMPRSS2-ERG Mutated PCa

The Moon Brothers have this mutation and that is probably why my Older brothers PSA went down over the last 8 months on nitric oxide supplement after getting off of Xtandi for about 8 months and PSA went from 0.076 to 6.2 with doubling time of less than every two months. His PSa on Nitric Oxide over the last 8 months went from 6.2 to 1.6 and was not doubling!!! He got on Nitric oxide at my suggestion to help walk and prevent falling. On Xtandi he had gotten to the point he needed a cane to walk to prevent falling. Now, he seldom needs a cane. I am building muscle with Nitric Oxide and have double the weight I can lift and the number of repeats I lift over the last year. I suggest you consider testing nitric oxide booster ( from SNAP Inc) for muscle building and prevent falls but check its effect on your PSA after you have used it a short while (a month or two) as I do not know how it will affect other mutations in PCa.
See below
Best
Peter

To Read the Papers - Click on the Link Below:

Link : "Supplementation"
or Go To
http://rvaprostatecancersupport.org/PDF/3 21 21 Mancarella.pdf

Us Too Warriors,
10 way s to Lower PSA Now

10 Things That Lower PSA Levels (And Some Things That Increase It)
See below
Best
Peter

To Read the Papers - Click on the Link Below:

Link : "PSA"
or Go To
https://prostate.net/10-things-lower-psa-levels/

Us Too Warriors,
Study of matrix Metalloproteinases and their inhibitors in prostate cancer

MMPs stands for Matrix Metalloproteinases. They are a group of 26 enzymes which breakdown matrix Collagen proteins in the body including extracellular matrix which encapsulates the PCa tumor to help keep PCa from spreading to the rest of the body organs==>Metastasis.. So things which stop MMPs keep Cancer from spreading. In dentistry it stops dental decay, osteoporosis, and tooth loss from destruction of tooth perio ligaments. In dentistry Doxycycline antibiotic chips are placed in the Tooth sulcus deep pockets to protect the perio ligament from bacteria producing MMPs. I take an off label 100 mg of Doxycycline pill/day for years (a lower dose than antibacterial level to block MMPs in the body to keep PCa from spreading and not kill gut bacteria needed for digestion) .This antibiotic blocks MMP2, 3 and 9. However, I have recently found MMP11 and MMP13 causes cancer to progress so I am looking at ways(supplements) to block MMP 11 & 13. (see attached paper below.. I am also finding evidence that MMP13 also causes the pain and burning in neuropathic pain and blocking them helps recovery from neuropathy. More information to follow as I find it on MMP11 and 13. Casodex and Xtandi may block MMP13.
See below
Best
Peter

To Read the Papers - Click on the Links Below:

Link 1 : "Metalloproteinases"
or Go To
http://rvaprostatecancersupport.org/PDF/3 17 21 Escaff-2010-Study-of-matrix-metalloproteinases-.pdf

*
Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Prostate Cancer Progression
Link 2 : "Natural Inhibitors "
or Go To
http://rvaprostatecancersupport.org/PDF/3 17 21 cancers-06-01298.pdf

*********************************************
Us Too Warriors,
How to use MRI for Active Surveillance.

INTRODUCTION
Worldwide, prostate cancer is the second most common cancer diagnosed in men according to data from the GLOBOCAN database. In the United States, it is estimated that prostate cancer will be diagnosed in approximately 248,530 men in the United States in 2021 and account for approximately 34,130 deaths [1].

Although widespread use of serum prostate-specific antigen (PSA) screening of healthy men has resulted in decreases in cancer-related mortality, this benefit has been accompanied by increased detection and treatment of many cancers bearing low metastatic potential (ie, clinically insignificant lesions) [2]. (See "Screening for prostate cancer", section on 'PSA testing'.)
See below
Best
Peter

To Read the Article - Click on the Link Below:

Link 1 : "MRI"
or Go To
https://www.uptodate.com/contents/the-role-of-magnetic-resonance-imaging-in-prostate-cancer#!

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Us Too Warriors,
Nitric Oxide

I told you about my brother, Don (28 year PCa survivor), lowering his PSA after it was at 6.2 after 8 months after being at 0.078 8 months before when he stopped Xtandi. His PSA was doubling every two months when 8 months off Xtandi. He Got off the Xtandi because of the fatigue it caused ( on it for 4 years) and the trouble he had walking. I told him to take "Nitric Oxide Booster " from Snap Inc. to help his muscles so he could walk better at 85 and to fight blood Clots from Covid. But he had the Bonus of his PSA falling from 6.2 to 1.6 over a period of 8 months. The paper attached below says that High NItric Oxide can reduce the androgen receptors to reduce cancer growth and that low nitric Oxide in the blood may make the cancer more likely to grow to become Castration resistant.

My Family has a germline mutation ( TMPRSS2-ERG Mutation) that makes me and my two brothers very susceptible to androgen (Testosterone) causing PCa growth - 50% or more of men are supposed to have this mutation. The Paper that follows suggests that PCa men can benefit from Nitric Oxide Booster to slow PCa.

Jerry Dean is going to try this to see if it helps?? And improve his muscles and fatigue from many rounds of Chemo. I have Found my Muscles are growing at 80 years, especially in my chest to point with my increasing exercise level. They are now bigger than they have ever been and I am now able unscrew jar lids better that I have in the last 30+ years.
See below
Best
Peter

Abstract:
Nitric oxide (NO) is a ubiquitous signaling molecule in the human body with well-known roles in many different processes and organ systems. In cancer, the two-concentrations hypothesis of NO has dictated that low levels of NO are cancer promoting, while high levels of NO are protective against cancer. Although prostate cancer is a hormonally driven malignancy, research has been shifting away from androgen-responsive epithelial cells and evolving to focus on NO therapies, the tumor microenvironment (TME), and inflammation. NO is reported to be able to inhibit activity of the androgen receptor. This may prevent prostate growth, but low levels of NO could conversely select for castration-resistant prostate cells, creating an aggressive cancer phenotype. At high levels, nitrosative stress created from NO overproduction can be protective against prostate neoplasia. In this review, we discuss development and possibilities of NO-based therapies for prostate cancer.

To Read the Paper - Click on the Link Below:

Link 1 : "Nitric Oxide"
or Go To
http://rvaprostatecancersupport.org/PDF/3 17 21 Nitric Oxide.pdf

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Us Too Warriors,
Paper with Topical amitriptyline, ketamine, and lidocaine in neuropathic pain caused by radiation skin reaction

Please find attached a paper which describes some over the counter treatments for Radiation sensitivity.
See below
Best
Peter

To Read the Paper - Click on the Links Below:

Link 1 : "Pain"
or Go To
http://rvaprostatecancersupport.org/PDF/3 15 21 Uzaraga-2012-Topical-amitriptyline-ketamine-and--1.pdf

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Us Too Warriors,
Curcumin (and Turmeric?) may make radiation treatment for cancer more effective and reduce Side effects

Curcumin is refined from Turmeric but some companies add ingredients that make its absorption in the blood go from 2% for tumeric to 25% or more for Curcumin. I use the life Extension Curcumin Elite (15 pills a day) to fight my PCa.

Curcumin (and Turmeric?) may make radiation treatment for cancer more effective and reduce the Side effects.
See below
Best
Peter

To Read the Paper - Click on the Links Below:

Link 1 : "Curcumin"
or Go To
http://rvaprostatecancersupport.org/PDF/3 14 21 Verma-2016-Relationship-and-interactions-of-cu.pdf

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Us Too Warriors,
Drug for mTor1/2 Bone Mets

The paper attached below is for a new drug tested on mice that blocks both forms of mTor (1/2) which is important because drugs that block only one form of mTor will fail in a short time for PCa.
See below
Best
Peter

Bone metastasis is the leading cause of prostate cancer (PCa) mortality, frequently marking the progression to castration-resistant PCa. Dysregulation of the androgen receptor pathway is a common feature of castration-resistant PCa, frequently appearing in association with mTOR pathway deregulations. Advanced PCa is also characterized by increased tumor heterogeneity and cancer stem cell (CSC) frequency. CSC-targeted therapy is currently being explored in advanced PCa, with the aim of reducing cancer clonal divergence and preventing disease progression. In this study, we compared the molecular pathways enriched in a set of bone metastasis from breast and prostate cancer from snap-frozen tissue. To further model PCa drug resistance mechanisms, we used two patient-derived xenografts (PDX) models of bone-metastatic PCa, BM18, and LAPC9. We developed in vitro organoids assay and ex vivo tumor slice drug assays to investigate the effects of mTOR- and CSC-targeting compounds. We found that both PDXs could be effectively targeted by treatment with the bivalent mTORC1/2 inhibitor Rapalink-1. Exposure of LAPC9 to Rapalink-1 but not to the CSC-targeting drug disulfiram blocked mTORC1/2 signaling, diminished expression of metabolic enzymes involved in glutamine and lipid metabolism and reduced the fraction of CD44+ and ALDEFluorhigh cells, in vitro. Mice treated with Rapalink-1 showed a significantly delayed tumor growth compared to control and cells recovered from the tumors of treated animals showed a marked decrease of CD44 expression. Taken together these results highlight the increased dependence of advanced PCa on the mTOR pathway, supporting the development of a targeted approach for advanced, bone metastatic PCa.

To Read the Paper - Click on the Links Below:

Link 1 : "Bone"
or Go To
http://rvaprostatecancersupport.org/PDF/3 10 21 fonc-10-01012.pdf

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Us Too Warriors,
Zinc Metallochaperones as Mutant p53 Reactivators: A New Paradigm in Cancer Therapeutics

Best
Peter

Abstract:

Restoration of wild-type structure and function to mutant p53 with a small molecule (hereafter referred to as “reactivating” mutant p53) is one of the holy grails in cancer therapeutics. The majority of TP53 mutations are missense which generate a defective protein that is targetable. We are currently developing a new class of mutant p53 reactivators called zinc metallochaperones (ZMCs) and, here, we review our current understanding of them. The p53 protein requires the binding of a single zinc ion, coordinated by four amino acids in the DNA binding domain, for proper structure and function. Loss of the wild-type structure by impairing zinc binding is a common mechanism of inactivating p53. ZMCs reactivate mutant p53 using a novel two-part mechanism that involves restoring the wild-type structure by reestablishing zinc binding and activating p53 through post-translational modifications induced by cellular reactive oxygen species (ROS). The former causes a wild-type conformation change, the later induces a p53-mediated apoptotic program to kill the cancer cell. ZMCs are small molecule metal ion chelators that bind zinc and other divalent metal ions strong enough to remove zinc from serum albumin, but weak enough to donate it to mutant p53. Recently we have extended our understanding of the mechanism of ZMCs to the role of cells’ response to this zinc surge. We found that cellular zinc homeostatic mechanisms, which normally function to maintain free intracellular zinc levels in the picomolar range, are induced by ZMCs. By normalizing zinc levels, they function as an OFF switch to ZMCs because zinc levels are no longer sufficiently high to maintain a wild-type structure. This on/off switch leads to a transient nature to the mechanism of ZMCs in which mutant p53 activity comes on in a few hours and then is turned off. This finding has important implications for the translation of ZMCs to the clinic because it indicates that ZMC concentrations need not be maintained at high levels for their activity. Indeed, we found that short exposures (as little as 15 min) were adequate to observe the mutant p53 reactivating activity. This switch mechanism imparts an advantage over other targeted therapeutics in that efficacy can be accomplished with minimal exposure which minimizes toxicity and maximizes the therapeutic window. This on/off switch mechanism is unique in targeted cancer therapeutics and will impact the design of human clinical trials

To Read the Paper - Click on the Links Below:

Link 1 : "Zinc"
or Go To
http://rvaprostatecancersupport.org/PDF/3 10 21 cancers-10-00166-1.pdf

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Us Too Warriors,
Sesamin inhibits lipopolysaccharide-induced proliferation and invasion through the p38-MAPK and NF-κB signaling pathways in prostate cancer cells

Dr. Prachya Kongthaweelert, deputy associate professor at The Thailand Excellence Center for Tissue Engineering and Stem Cells at Chiang Mai University, said that, while black sesame seeds look simple enough, they have very beneficial properties to those with cancer. He and his team have discovered that extracting “Sesamin,” a natural chemical compound from the seeds, and using it as part of cancer treatment can slow or stop the growth of cancer cells and create an environment in the body that stimulate antibodies, according to Thai PBS.
Best
Peter

Abstract:

Sesamin, a lipid-soluble lignan, is one of the major constituents of sesame. Previous studies have reported that sesamin induces growth inhibition in human cancer cells, particularly prostate cancer cells. In the present study, we mainly explored the mechanism underlying the protective effect of sesamin on prostate cancer cell proliferation and invasion induced by lipopolysaccharide (LPS). We found that the proliferation of PC3 cells, as determined using the MTT assay, and the expression of cyclin D1, COX-2, Bcl-2 and survivin proteins elevated by LPS were distinctly inhibited by sesamin in a dosedependent manner. Meanwhile, the ability of PC3 cell invasion, as determined using the Transwell assay and the expression of matrix metalloproteinase 9 (MMP-9), intercellular adhesion molecule-1 (ICAM-1) and vascular endothelial growth factor (VEGF) proteins increased by LPS were obviously reduced by sesamin in a dose-dependent manner. In addition, the accumulation of TGF-α and interleukin-6 (IL-6) production induced by LPS in the culture supernatant was found to be decreased dose-dependently with sesamin pretreatment in PC3 cells using the enzyme-linked immunosorbent assay (ELISA) kit. Furthermore, phosphorylation of the p38 protein and nuclear factor (NF)-κB activity in the PC3 cells were enhanced by LPS and further inhibited with sesamin, SB203580 pretreatment or p38-siRNA transfection, respectively. Sesamin or SB203580 pretreatment obviously inhibited PC3 cells-derived tumor growth induced by LPS in vivo. Taken together, these results suggest that the potential ability of sesamin to downregulate the secretion of cytokines and the expression of cell proliferative- and invasive-related gene products induced by LPS was shown to be via the p38 mitogen-activated protein kinase (p38-MAPK) and NF-κB signaling pathways, which may be one of the mechanisms of the anticancer activity of this sesamin agent in prostate cancer cells.

To Read the Paper - Click on the Links Below:

Link 1 : "Sesamin"
or Go To
http://rvaprostatecancersupport.org/PDF/3 9 21 or_33_6_3117_PD.pdf

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Us Too Warriors,
Association of Bone Metastatic Burden With Survival Benefit From Prostate Radiotherapy in Patients With Newly Diagnosed Metastatic Prostate Cancer

Best
Peter

IMPORTANCE: Prostate radiotherapy (RT) improves survival in men with low-burden metastatic prostate cancer. However, owing to the dichotomized nature of metastatic burden criteria, it is not clear how this benefit varies with bone metastasis counts and metastatic site.

OBJECTIVE To evaluate the association of bone metastasis count and location with survival benefit from prostate RT.

To Read the Paper - Click on the Links Below:

Link 1 : "Burden"
or Go To
http://rvaprostatecancersupport.org/PDF/3 9 21 jamaoncology_ali_2021_oi_200113_1612551450.8.pdf

***********************************
Us Too Warriors,
Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection

Statins and Zinc are good to fight Covid. Best
Peter

Abstract: Background:
Zinc is an essential micronutrient that impacts host–pathogen interplay at infection. Zinc balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases, two groups with an increased risk for severe severe coronavirus disease 2019 (COVID-19) outcomes. We hypothesize that serum zinc content (SZC) influences COVID-19 disease progression, and thus might represent a useful biomarker. Methods: We ran an observational cohort study with 249 COVID-19 patients admitted in Hospital del Mar. We have studied COVID-19 severity and progression attending to SZC at admission. In parallel, we have studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) replication in the Vero E6 cell line modifying zinc concentrations. Findings: Our study demonstrates a correlation between serum zinc levels and COVID-19 outcome. Serum zinc levels lower than 50 µg/dL at admission correlated with worse clinical presentation, longer time to reach stability, and higher mortality. Our in vitro results indicate that low zinc levels favor viral expansion in SARS-CoV-2 infected cells. Interpretation: Low SZC is a risk factor that determines COVID-19 outcome. We encourage performing randomized clinical trials to study zinc supplementation as potential prophylaxis and treatment with people at risk of zinc deficiency.

To Read the Papers - Click on the Links Below:

Link 1 : "Zinc"
or Go To
http://rvaprostatecancersupport.org/PDF/3 9 21 nutrients-13-00562.pdf

*

Link 2 : "Statin"
or Go To
http://rvaprostatecancersupport.org/PDF/3 9 21 Statin users 50.pdf

*********************************************************************
Us Too Warriors,
Papers on Scanning of PCa for mets etc. resent with papers NOW attached

Check these 2 papers to see when Scanning works WELL. Best
Peter

Abstract:
Prostate cancer–specific positron emission tomography (pcPET) has been shown to detect sites of disease recurrence at serum prostate-specific antigen (PSA) levels that are lower than those levels detected by conventional imaging. Commonly used pcPET radiotracers in the setting of biochemical recurrence are reviewed including carbon 11/fludeoxyglucose 18 (F-18) choline, gallium 68/F-18 prostatespecific membrane antigen (PSMA), and F-18 fluciclovine. Review of the literature generally favors PSMAbased agents for the detection of recurrence as a function of low PSA levels. Positive gallium 68/F-18 PSMA positron emission tomography/computed tomography scans detected potential sites of recurrence in a median 51.5% of patients when PSA level is b1.0 ng/mL, 74% of patients when PSA level is 1.0 to 2.0 ng/mL, and 90.5% of patients when PSA level is N2.0 ng/mL. Review of carbon 11/fludeoxyglucose 18 (F-18) choline and F-18 fluciclovine data commonly demonstrated lower detection rates for each respective PSA cohort, although with some important caveats, despite having similar operational characteristics to PSMA-based imaging. Sensitive pcPET imaging has provided new insight into the early patterns of disease spread, which has prompted judicious reconsideration of additional local therapy after either prostatectomy, definitive radiation therapy, or postprostatectomy radiation therapy. This review discusses the literature, clinical utility, availability, and fundamental understanding of pcPET imaging needed to improve clinical practice. © 2017 The Authors. Published by Elsevier Inc. on behalf of American Society for Radiation Oncology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

To Read the Papers - Click on the Links Below:

Link 1 : "Link 1"
or Go To
http://rvaprostatecancersupport.org/PDF/3 8 21 Zhou2019_Article_ComparisonOfPSMA-PETCTCholi.pdf

*

Link 2 : "Link 2"
or Go To
http://rvaprostatecancersupport.org/PDF/3 8 21 PIIS1879850017302060.pdf

***********************************
Us Too Warriors,
Melatonin for bone health and PCa Mets

I have been using Melatonin at 50mg /night and My wife at 80 mg/night for years. See the Paper attached below for its benefit for PCa & bones.
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Melatonin"
or Go To
http://rvaprostatecancersupport.org/PDF/3 7 21 Liu-2021-Melatonin-interrupts-osteoclast-fun.pdf

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Us Too Warriors,
Add Spices to your Diet to Fight cancer

The Slide show Attached below will give you many ideas of Food & Spices you can add to your diet to fight your cancer and make your food taste great too!! You will see in the slides that India and China that make and use the most spices have much less cancer than the USA

My mother, who traveled in China, was very creative in using spices and I followed her lead. What I like about stir fries is I can get everything into the dish and I am looking for more spices as I go to Indian food stores. I found this slide website when trying to see how Sesame Seed might fight PCa. Between my Supplements and spices I may use 50% of agents covered in the slides. But I see I have many more to find and investigate. I hope you find it helpful to see how they fight the inflammation that promotes cancer.

Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Spices"
or Go To
http://rvaprostatecancersupport.org/PDF/3 6 21 19...aggarwal.pdf

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Us Too Warriors,
Polaris Gene Test

Check out this website Below (https://prostatecancernewstoday.com/2021/02/23/prolaris). This gene test test-identifies-higher-risk-patients who can safely-skip- ADT treatment or those should add it to their radition.

It has good information on reducing Mets from 25% to less than 3.9% at 10 years by Adding ADT to Radiation treatment if you are in a high risk Group as shown by this test.

Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Polaris"
or Go To
https://prostatecancernewstoday.com/2021/02/23/prolaris-test-identifies-higher-risk-patients-safely-skip-adt/

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Us Too Warriors,
Treatment with Cabergoline (Dopamine agonist)

I have been using Dostinex prescription (Dr. Meyers recommendation) for about 13 years at 1 or 2 half pills per week. I have not talked about it because I did not know how it worked. But the recent attached paper reports that it can put PCa in remission for men that had ADT - that no longer works which is GREAT so I want you to know about.

I am in the process of sending my Oldest brother (had ADT treatment) an excess of my pills to try to see if they will work for him as he has similar Genes we hope so we will become an N21/2 in the Moon Brother's Clinic Trial. For my next oldest brother, I think I have slowed his cancer by 12 years, as I have him on half my drugs thru his GP Doctor who I talked to for him and they have dropped his PSA several times from 3+ to 1.1 after he was diagnose with high grade PINs ( a precancers condition in 2006).

If you have been or are on ADT treatment read the paper attached paper carefully! You may want may want to get your Prolactin blood level tested to see if you a good candidate for the use of the Drug Dostinex for your PCa. see Paper that follows .
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Cabergoline"
or Go To
http://rvaprostatecancersupport.org/PDF/3 6 21 nihms-1019063.pdf

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Us Too Warriors,
Vit K2

Please find below Paper exposing the Benefits of Vitamin k2 for Bone and advanced PCa health.

Lef.org has a new very high dose Vitamin K2 Supplement (45 mg) which I have just started taking. I had been taking their low dose of K1 and K2 pills for years. The high dose level used in the european studies is very effective and is available from Life extension see below. What is Copied below is the Life Extension article from the 2018 magazine which is on the Virginia Urology website (Will WONDERS NEVER CEASE!!!!)
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Life Extension"
or Go To
https://www.lifeextension.com/vitamins-supplements/item02417/mega-vitamin-k2-high-potency-for-strong-bones?gclid=Cj0KCQiAhP2BBhDdARIsAJEzXlH2Xn1r5Enrol72WyTPKmSrIg6CpyIxn_0OaNtg5JBTq7c2QPjJAnsaAtubEALw_wcB

To go to the Wewbsite - Click on the Link Below:

Link : "Article"
or Go To
https://www.lifeextension.com/magazine/2009/1/vitamin-k-protection-against-arterial-calcification-bone-loss-cancer-aging
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Us Too Warriors,
Drug that that can over come ADT of Xtandi resistance when CRPC occurs

Patients with castration resistant prostate cancer (CRPC) usually have a poor prognosis. In part, this is due to the cancer’s ability to resist anti-androgen therapy. A study shows that combining a CPT1A inhibitors with anti-androgen therapy increases the cancer’s sensitivity to the anti-androgen drug enzalutamide.
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "(CRPC)"
or Go To
https://www.sciencedaily.com/releases/2017/05/170515125937.htm
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Us Too Warriors,
New drug being Clinical tested = CC#1477 that Blocks p300 and CBP binding and so does CURCUMIN to fight PCa

P300 and CBP are proteins in PCa cancer cells. When the proteins are bound together and go to the cell nucleus they Grow PCa. Eight years ago I went to a Research seminar at VCU Massey cancer Center by a Doctor from Philadelphia that presented his research that proteins p300 and CBP bind together to form a heterodimer protein group which when it goes to the nucleus it grows the PCa. For this reason, I increased my Super Biocurcumin from LEF.org from 9 pills per day to 15 pills a day which I still take them today. More information on Curcumin below at: https://www.mdpi.com/2218-273X/10/11/1536/htm
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "New drug"
or Go To
http://rvaprostatecancersupport.org/PDF/3 1 21 biomolecules-10-0153.pdf

To go to the Wewbsite - Click on the Link Below:

Link : "CURCUMIN"
or Go To
https://www.mdpi.com/2218-273X/10/11/1536/htm

Us Too Warriors,
Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer

Emergence of an aggressive androgen receptor (AR)-independent neuroendocrine prostate cancer (NEPC) after androgen-deprivation therapy (ADT) is well-known. Nevertheless, the majority of advanced-stage prostate cancer patients, including those with SPINK1-positive subtype, are treated with AR-antagonists. Here, we show AR and its corepressor, REST, function as transcriptional-repressors of SPINK1, and AR-antagonists alleviate this repression leading to SPINK1 upregulation. Increased SOX2 expression during NE-transdifferentiation transactivates SPINK1, a critical-player for maintenance of NE-phenotype. SPINK1 elicits epithelial-mesenchymal-transition, stemness and cellular-plasticity. Conversely, pharmacological Casein Kinase-1 inhibition stabilizes REST, which in cooperation with AR causes SPINK1 transcriptional-repression and impedes SPINK1-mediated oncogenesis. Elevated levels of SPINK1 and NEPC markers are observed in the tumors of AR-antagonists treated mice, and in a subset of NEPC patients, implicating a plausible role of SPINK1 in treatment-related NEPC. Collectively, our findings provide an explanation for the paradoxical clinical-outcomes after ADT, possibly due to SPINK1 upregulation, and offers a strategy for adjuvant therapies.
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "SPINK1"
or Go To
http://rvaprostatecancersupport.org/PDF/2 26 21 s41467-019-14184-0-1.pdf
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Us Too Warriors,
Genomic variations associated with prostate cancer in large cohort of African American men.

Racial disparities in prostate cancer (PCa) incidence and mortality are well known. PCa is known to be more aggressive in African American men (AAM) in terms of higher incidence and mortality rates. Here we validate a tumor gene expression pan-cancer race model in men with PCa and further characterize genomic differences that may contribute to disparate clinical outcomes
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Genomic Variations"
or Go To
https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.6_suppl.20
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Us Too Warriors,
Mutational Drivers of cancer cell migration and invasion

This recent paper below is what we have to stop to fight cancer.
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Mutational Drivers"
or Go To
http://rvaprostatecancersupport.org/PDF/2 24 21 s41416-020-01149-0.pdf
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Us Too Warriors,
"Wormwood" from Swanson is my Source of Artemisinin

See the attached paper on Artemisinin. I also got some Artemisinin seeds to plant when it is warmer (research discovery of Artemisinin and its benefits won a Noble prize in 2015). Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Artemisinin"
or Go To
http://rvaprostatecancersupport.org/PDF/2 23 21 molecules-21-01331.pdf
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Us Too Warriors,
Paper attached on ways to make P53 negative PCa more able to responded chemotherapy

The paper below looks like it could be helpful.

Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Paper"
or Go To
http://rvaprostatecancersupport.org/PDF/2 23 21 aging-12-103377-1.pdf
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Us Too Warriors,
Beginning of a break thru in Advanced cancer P13K_AKT_mTOR pathways

It has been hard to crack the CODE to stop advanced cancer with P53 or/And P10 Mutations.

We have one member who responded to Rapamycin while having multiple bone mets which treats mTOR pathway which has an mTOR1 and mTOR2 paths that both have to be blocked which worked for him in a John Hopkins Clinical Trial to put him in remission. But he was one of the few to respond. It appears that if you have mutations in P53 or/and P10 you may need to block most or All the P13K_AKT_mTOR pathways. The attached paper discusses the research to try to accomplish this Goal to extend life.

Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Pathways"
or Go To
https://www.urotoday.com/clinical-trials/from-the-editor/126829-pi3k-akt-mtor-inhibitors-for-prostate-cancer-finally-hints-of-a-breakthrough.html#:~:text=PI3K/AKT/mTOR%20Inhibitors%20for%20Prostate%20Cancer%20%E2%80%93%20Finally%20Hints,castration-resistant%20prostate%20cancer.%201,2%20Not%20surprising%20is

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Us Too Warriors,
Statin treatments for Advanced PCa have improved survival

It appears that from the attached paper below that the Lipophilic statin = Pitavastatin is the most effective in preventing PCa deaths and the second best is the Hydrophilic Statin = Pravastatin. I got my GP doctor to prescribe Pravastatin about a year ago as my LDL was higher than it had been. It is now lower, but I may talk to him about Pitavastatin as it is significantly better for PCa survival.

The website below is another paper about statins but it does not have much on pitastatin as there were not many men using it. Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Statin"
or Go To
http://rvaprostatecancersupport.org/PDF/2 21 21 Wu-2019-Mortality-associated-with-statins-i.pdf

To go to the Website - Click on the Link Below:

Link : "Website"
or Go To
https://www.cancernetwork.com/view/statins-associated-lower-all-cause-and-prostate-cancer-mortality
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Us Too Warriors,
Anticancer Properties of Capsaicin Against Human Cancer

Abstract.
There is persuasive epidemiological andexperimental evidence that dietary phytochemicals haveanticancer activity. Capsaicin is a bioactive phytochemical abundant in red and chili peppers. While the preponderance of the data strongly indicates significant anticancer benefitsof capsaicin, more information to highlight molecular mechanisms of its action is required to improve our knowledge to be able to propose a potential therapeutic strategy for use of capsaicin against cancer. Capsaicin has been shown to alter the expression of several genes involved in cancer cell survival, growth arrest, angiogenesis and metastasis. Recently,many research groups, including ours, found that capsaicin targets multiple signaling pathways, oncogenes and tumor-suppressor genes in various types of cancer models. In this review article, we highlight multiple molecular targets responsible for the anticancer mechanism of capsaicin. In addition, we deal with the benefits of combinational use of capsaicin with other dietary or chemotherapeutic compounds,focusing on synergistic anticancer activities.

Best
Peter

To Read - Click on the Link Below:

Link 1 : "Capsaicin"
or Go To
http://rvaprostatecancersupport.org/PDF/2 20 21 PCa-Capsaicin837.pdf

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Us Too Warriors,
ERG genes that fuses with TMPRSS2 genes promotes advanced aggressive cancers with the P53 and P10 negative Mutations

To stop these dangerous PCa's we need to find a way to knock down the formation of ERG genes that promote their growth!!

My family with theTMPRSS2-ERG Fusion Mutation are prone to this Cancer Gene

Family and friends, The way to fight ERG cancer oncogene is to find agents which will reduce its formation or cause it to disinigrate. I am on the trail of agents to do this, but these oncogene dangers are only recently recognized and its treatment is not fully developed so stay tuned.

The attached papers discusses agents that may accomplish this but at this point I do not recognize any agent that is easily available. It is going to take more research to find one or to locate a paper describing its action.

The attached paper discusses agents that may accomplish this but at this point I do not recognize any agent that is easily available. It is going to take more research to find one or to locate a paper describing its action.

Best
Peter

To Read the Articles - Click on the Link Below:

Link 1 : "Mutations"
or Go To
http://rvaprostatecancersupport.org/PDF/2 6 21 onc2015109.pdf

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To Read the Articles - Click on the Link Below:

Link 2 : "Nuclear factor kappa B"
or Go To
http://rvaprostatecancersupport.org/PDF/2 7 21 2402482 (1).pdf

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To Read the Articles - Click on the Link Below:

Link 3 : "Vitamin D Receptor"
or Go To
http://rvaprostatecancersupport.org/PDF/2 7 21 Washington-2010--dihydroxyvitamin-d-inhibits-growth.pdf

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Us Too Warriors,
Off label Drugs

Off label Drugs for fighting PCa see papers below
See Below

Best
Peter

To Read the Article - Click on the Link Below:

Link : "Off label Drugs"
or Go To
http://rvaprostatecancersupport.org/PDF/2 3 21 Off label Drugs for fighting PCa.pdf

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Us Too Warriors,
Terazosin - Prostate Drug Associated With Lower Risk of Parkinson’s Disease

Terazosin, a medication prescribed to treat enlarged prostate, was associated with a lower risk of developing Parkinson’s disease.
See Below

Best
Peter

To Read the Article - Click on the Link Below:

Link : "Terazosin"
or Go To
https://neurosciencenews.com/prostate-drug-parkinsons-17645/

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Us Too Warriors,
Xtandi VS Lower dose (50mg) Casodex for metastatic hormone sensitive PCa both included ADT Lupron

Paper below Compares to treatments for Xtandi VS Lower dose (50mg) Casodex.

My Brother , Don, used Xtandi and Metformin and ADT prescribed by Doctor Snuffy Myers for 4 years that controlled his cancer at a low PSA (.078) from a value above 10 + at start until the Fatigue last year as side effect became too much and made walking hard ay 84 years so he quite ADT and Xtandi June 2019. His PSA went up to 6.8 in a year (June 2020) at which time I suggested he start taking a "Nitric Oxide Booster by Snap Inc" to fight Covid-19 which turns out to fight PCa too. His PSA after 6 months has dropped to 1.2.

I use Casodex (at higher dose 150mg/day) with metformin and etc etc But NO ADT which dropped my PSA from high 12.2 with multiple mets to a low of 0.0152 June 2020. My PSA has gone up a little in the last 6 Months to 0.056 which initially had a doubling time of every 5 months in October but had slowed to every 12 months in December 2020. So I have had a ride on this treatment for 3 years so far and hope to keep it growing even more slowly for another 3+ years if possible. Casodex has the benefit of preventing bone osteoporosis better than treatments with ADT and not producing fatigue. I also have reduced breast pains with several aromatases and this may keep estrogen out of the Estrogen alpha androgen receptor which may reduce PCa growth too.

I hope this helps. My brother Don has had PCa for 27 years and I have had it for 26 years.

Best
Peter

To Read the Article - Click on the Link Below:

Link : "Xtandi"
or Go To
http://rvaprostatecancersupport.org/PDF/1 30 21 vaishampayan_2021_oi_201051_1611109178.02501 (1).pdf

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Us Too Warriors,
CBD oil, Berberine and Hesperidin Supplements Benefits

Check out these websites for CBD oil, Berberine and Hesperidin supplements benefits.

Best
Peter

To See the Websites - Click on the Links Below:

Link 1: "Link 1"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682269/

Link 1: "Link 2"
or Go To
https://pubmed.ncbi.nlm.nih.gov/24025684/
Link 1: "Link 3"
or Go To
https://pubmed.ncbi.nlm.nih.gov/23353054/
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Us Too Warriors,
Comparison of Cabiataxel VS LU177 treatment of PCA mets of CRPC

(UroToday.com) During the second day of the 2020 Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP) Mini Annual Scientific Meeting (ASM), two sessions examined key trials in ANZUP. The first of these focused on trials in prostate cancer and germ cell tumors. In the prostate session, Dr. Louise Emmett led a discussion of the TheraP trial along with Drs. Michael Hofman and Peter Grimison.

Best
Peter

To Read the Article - Click on the Link Below:

Link : "Comparison"
or Go To
https://www.urotoday.com/conference-highlights/anzup-mini-asm-2020/anzup-2020-gu-malignancies-prostate/126232-anzup-mini-asm-2020-prostate-therap-and-the-global-context-of-therap-and-pathway-to-approval.html?utm_source=newsletter_8712&utm_medium=email&utm_campaign=developments-on-the-horizon-targeted-molecular-therapies-in-the-treatment-of-metastatic-castration-resistant-prostate-cancer-mcrpc

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Us Too Warriors,
Radiation given for PCa when a person is most active during the day gives fewer side effects

Radiation given for PCa when a person is most active during the day gives fewer side effects from the treatment for PCa and BCa.

Best
Peter

To Read the Article - Click on the Link Below:

Link : "Radiation"
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/140627199/afternoon-radiotherapy-reduces-side-effects-for-some-patients

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Us Too Warriors,
Covid-Prostate Mine Field

Check this website to get a guide to negotiate the covid-prostate mine field.

Best
Peter

To Read the Article - Click on the Link Below:

Link : "Mine Field"
or Go To
https://www.pcf.org/guide/prostate-cancer-patient-guide/

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Us Too Warriors,
Supplement to restore P53 mutant protein to an anti-cancer fighting protein = Watercress

To Jerry and any other Us too Warriors that have Mutated P53 Proteins affecting the growth of their cancer -Watercress contains the active agent.

This sentence is copied from the paper: " we reported that phenethyl isothiocyanate (PEITC), abundant in watercress, selectively depletes mutant p53, but not wild-type (WT) p53, in a variety of human cancer cell lines [14]" I take Watercress pill (3/d) from Swanson with the hope it will keep my P53 from mutating, but if I knew it was mutated i would take 15 pills/day and buy fresh watercress from a market and eat a bunch every day. In Richmond, http://newgrandmart.com/

This Grand Mart has carried Watercress in the Westend and is found in West Broad Commons Shopping Ctr. at 9040 Broad street.

Best
Peter

To Read the Article - Click on the Link Below:

Link : "Watercress"
or Go To
http://rvaprostatecancersupport.org/PDF/1 22 21 PP-XDI-USA-0219Living Healthy Cookbook with Information about Urologic Cancers-1.pdf

Us Too Warriors,
COVID-19

I got my first Pfizer shot a week ago and I get the second in two weeks. But If you are having trouble finding a shot like I am for My wife - these supplements help to ward off or treat Covid infection see list:
Vitamin D3 ~8,000 IU/day (Good to Take Super Vitamin K (K2) rom Life extension also to put calcium in bones)
Zinc~ 50Mg/day Lactoferrin - 3 Swanson pills/day
Vitamin C~ 6,000 Mg/day
Nitric Oxide Booster- 3 pills/day From Snap Inc.
Brown seaweed -3 pills/day Swanson Inc
These will act to help fight PCa too so I will take them after my second covid shot.
See attached below.

Best
Peter

Impact of chronic exposure to 5-alpha reductase inhibitors on the risk of hospitalization for COVID-19: a case-control study in male population from two COVID-19 regional centers of Lombardy (Italy)

ABSTRACT

Background: There are sex differences in vulnerability to Coronavirus disease 2019 (COVID-19). The coronavirus S protein mediates viral entry into target cells employing the host cellular serine protease TMPRSS2 for S-protein priming. The TMPRSS2 gene expression is responsive to androgen stimulation and it could partially explain sex differences. We hypothesized that men chronically exposed to 5-alpha reductase inhibitors (5ARIs) for benign prostate hyperplasia (BPH) have a lower risk of hospitalization for COVID-19.

Methods: This is a population-based case-control study on consecutive patients positive for SARS-CoV-2 virus who required hospitalization for COVID-19 (cases), age-matched to beneficiaries of the Lombardy Regional Health Service (controls). Data were collected by two high-volume COVID-19 regional centers of Lombardy (Italy). The primary outcome was to compare the prevalence of patients chronically exposed to 5ARIs, who required hospitalization for COVID-19, with the one of controls.

Results: Overall, 943 males were enrolled; 45 (4.77%) were exposed to 5ARI. COVID-19 patients aged >55 years under 5ARI treatment were significantly less than expected on the basis of the prevalence of 5ARI treatment among age-matched controls (5.57 vs. 8.14%; p=0.0083, 95%CI=0.75-3.97%). This disproportion was higher for men aged >65 (7.14 vs. 12.31%; p=0.0001, 95%CI=2.83-6.97%). Eighteen 5ARIs-patients died; the mean age of men who died was higher than those who did not: 75.98±9.29 vs. 64.78±13.57 (p<0.001). Cox-regression and multivariable models did not show correlation between 5ARIs exposure and protection against intensive care unit admission/death.

Conclusions: Men exposed to 5ARIs might be less vulnerable to severe COVID-19, supporting its use in disease prophylaxis.

To Read the Book - Click on the Link Below:

Link : "COVID-19"
or Go To
https://pubmed.ncbi.nlm.nih.gov/33439572/
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Us Too Warriors,
Nutrition and Cancer

See attached paper below.

Best
Peter

ABSTRACT

Nutrition and Cancer

While each person and each cancer diagnosis is unique, general guidance before, during and after treatment includes eating nutritious foods to help focus on healthy habits. When you are healthy, eating enough food may not be a problem. But when you are dealing with cancer and treatment, this may be harder to do. Chemotherapy, surgery, radiation therapy and other cancer treatments may take a toll on the body. They may affect taste, smell, appetite, how much food is eaten and the ability to absorb nutrients from food. This cookbook is designed to help you think about what you eat and to help you select meals while you or someone you love is dealing with cancer. Talk with your physician or care team about cancer treatment, as well as about what to eat during cancer treatment. They may refer you to a dietitian who can help you with your diet and to choose foods and drinks during and after treatment.

To Read the Book - Click on the Link Below:

Link : "Cookbook"
or Go To
http://rvaprostatecancersupport.org/PDF/1 22 21 PP-XDI-USA-0219Living Healthy Cookbook with Information about Urologic Cancers-1.pdf
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Us Too Warriors,
Major Surgery Affects Memory in Individuals with Cerebral Amyloid- Pathology

See attached paper below. I had the experience of having a loss of mental graphical memory of my mental driving map when I drove around Richmond for several years after my Prostatectomy surgery at 54 years when driving around Richmond. It has mostly returned at 80 years, but this is a side effect of the anaesthesia you need to take seriously.

Best
Peter

ABSTRACT

Background: Major surgery has been associated with perioperative neurocognitive disorders (PND), but the contributing factors and long-term prognosis are uncertain. We hypothesize that preclinical Alzheimer’s disease (AD) might predispose to cognitive deterioration after surgery.

Objective: To analyze the effect of amyloid- on the cognitive trajectory after orthopedic surgery in a sample of non-demented subjects.

Methods: Non-demented individuals older than 65 years that were on the waiting list for orthopedic surgery with spinal anesthesia underwent a neuropsychological assessment before and after surgery. During surgery, cerebrospinal fluid samples were obtained to determine AD biomarkers.

To Read the Article - Click on the Link Below:

Link : "Memory"
or Go To
http://rvaprostatecancersupport.org/PDF/1 22 21 jad_2021_79-2_jad-79-2-jad191229_jad-79-jad1.pdf
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Us Too Warriors,
Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression1

My brother like me has the mutation TMPRSS2-ERG in hs PCa. He also has a garden with 50 Tomato plants he harvested his last tomatoes in Early January from his greenhouse. He would put up canned and frozen sauce every year with his wife's help. He has PCa mutation TMPRSS2-ERG Cancers like me. He had Pre cancerous PCa PINs in 1996. But he was diagnosed with cancer until the fall of 2019 with my help with my help getting him to take antioxidants and anti inflammatories and his own love of tomatoes. I was diagnosed in 1994 with PCa in spite of loving tomatoes. I did not eat as much as he did. So read below the paper attached for your information.

Best
Peter

ABSTRACT

Background: There is limited evidence that supports etiologically distinct molecular subtypes of prostate cancer, the identification of which may improve prevention. Given their antioxidant properties, we hypothesized that lycopene and tomato sauce may be especially protective against diseases harboring the common gene fusion transmembrane protease, serine 2 (TMPRSS2):v-ets avian erythroblastosis virus E26 oncogene homolog (ERG).

To Read the Article - Click on the Link Below:

Link 1: "Article"
or Go To
http://rvaprostatecancersupport.org/PDF/1 20 21 Pca- Tomato Lycopene and Tmprss2-erg mutationajcn118703.pdf
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Us Too Warriors,
For Increased Vitamin D Use To Combat COVID-19

Please read the letter below and use the benefits of this knowledge to protect you and your family. Vitamin D is low in people of darker skin color, nursing homes and all during the winter as the Sun is lower in the sky.

Best
Peter

Scientific evidence indicates vitamin D reduces infections & deaths - Dec 7, 2020

To all governments, public health officials, doctors, and healthcare workers,
[Residents of the USA: Text “VitaminDforAll” to 50409 to send this to your state’s governor.]
Research shows low vitamin D levels almost certainly promote COVID-19 infections, hospitalizations, and deaths. Given its safety, we call for immediate widespread increased vitamin D intakes.
Vitamin D modulates thousands of genes and many aspects of immune function, both innate and adaptive. The scientific evidence1 shows that:

To Read the Letter - Click on the Link Below:

Link 1: "Letter"
or Go To
http://rvaprostatecancersupport.org/PDF/1 20 21 Over 200.pdf
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Us Too Warriors,

Milk break produce can produce Lactate and lactic acid which may be used to grow bone cancers, Some Probiotics species may produce Lactic acid which is bad for PCa growth! This is one of the reasons I avoid milk products and cheese. And I am going to be careful in selecting the probiotics I use.

See statement below copied from a paper on probiotics and a paper attached about cancer mets in the back bone. See below. Best Peter

Bifidobacterium as a genus does not yield D-lactate as a metabolic end product. Some Lactobacillus species do (Table 19.1 in Pot 2014). Among common probiotic Lactobacillus species, the following are classified as species that can produce D-lactic acid: L. acidophilus, L. gasseri, L. delbrueckii subsp. bulgaricus (one of the 2 yogurt starter culture bacteria), L. fermentum, L. lactis, L. brevis, L. helveticus, L. plantarum and L. reuteri. Individual strains within each species may vary with regard to levels of D-lactic acid produced.

Best
Peter

Abstract:

Abstract: Spine tumors are among the most difficult tumors to treat given their proximity to the spinal cord. Despite advances in adjuvant therapies, surgery remains a critical component of treatment, both in primary tumors and metastatic disease. Given the significant morbidity of these surgeries and with other current adjuvant therapies (e.g., radiation, chemotherapy), interest has grown in other methods of targeting tumors of the spine. Recent efforts have highlighted the tumor microenvironment, and specifically lactate, as central to tumorigenesis. Once erroneously considered a waste product that indicated hypoxia/hypoperfusion, lactate is now known to be at the center of whole-body metabolism, shuttling between tissues and being used as a fuel. Diffusion-driven transporters and the near-equilibrium enzyme lactate dehydrogenase (LDH) allow rapid mobilization of large stores of muscle glycogen in the form of lactate. In times of stress, catecholamines can bind muscle cell receptors and trigger the breakdown of glycogen to lactate, which can then diffuse out into circulation and be used as a fuel where needed. Hypoxia, in contrast, is rarely the reason for an elevated arterial [lactate]. Tumors were originally described in the 1920’s as being “glucose-avid” and “lactate-producing” even in normoxia (the “Warburg effect”). We now know that a broad range of metabolic behaviors likely exist, including cancer cells that consume lactate as a fuel, others that may produce it, and still others that may change their behavior based on the local microenvironment. In this review we will examine the relationship between lactate and tumor metabolism with a brief look at spine-specific tumors. Lactate is a valuable fuel and potent signaling molecule that has now been implicated in multiple steps in tumorigenesis [e.g., driving vascular endothelial growth factor (VEGF) expression in normoxia]. Future work should utilize translational animal models to target tumors by altering the local tumor microenvironment, of which lactate is a critical part.

To Read the Paper - Click on the Link Below:

Link 1: "Lactate"
or Go To
http://rvaprostatecancersupport.org/PDF/1 16 21 atm-07-10-220.pdf
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Us Too Warriors,

Natural Agents to add to your amour to block P53 mutation and/or MDM2 binding to P53 you have found in your genes

I am going to suggest some supplement websites that may help with cancer and papers attached to support their use. See Below.

Best
Peter

Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine
Abstract:

The p53 tumor suppressor plays a major role in controlling the initiation and development of cancer by regulating cell cycle arrest, apoptosis, senescence, and DNA repair. The MDM2 oncogene is a major negative regulator of p53 that inhibits the activity of p53 and reduces its protein stability. MDM2, p53, and the p53-MDM2 pathway represent welldocumented targets for preventing and/or treating cancer. Natural products, especially those from medicinal and food plants, are a rich source for the discovery and development of novel therapeutic and preventive agents against human cancers. Many natural product-derived MDM2 inhibitors have shown potent efficacy against various human cancers. In contrast to synthetic small-molecule MDM2 inhibitors, the majority of which have been designed to inhibit MDM2- p53 binding and activate p53, many natural product inhibitors directly decrease MDM2 expression and/or MDM2 stability, exerting their anticancer activity in both p53-dependent and p53- independent manners. More recently, several natural products have been reported to target mutant p53 in cancer. Therefore, identification of natural products targeting MDM2, mutant p53, and the p53-MDM2 pathway can provide a promising strategy for the development of novel cancer chemopreventive and chemotherapeutic agents. In this review, we focus our discussion on the recent advances in the discovery and development of anticancer natural products that target the p53-MDM2 pathway, emphasizing several emerging issues, such

To Read the Paper - Click on the Link Below:

Link 1: "Natural Products"
or Go To
http://rvaprostatecancersupport.org/PDF/1 13 21 Natural products targeting the p53-MDM2 main.pdf
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Fucoxanthin and Its Metabolite Fucoxanthinol in Cancer Prevention and Treatment
See Below

ABSTRACT
Fucoxanthin is a carotenoid present in the chloroplasts of brown seaweeds. When ingested, it is metabolized mainly to fucoxanthinol by digestive enzymes of the gastrointestinal tract. These compounds have been shown to have many beneficial health effects, including anti-mutagenic, anti-diabetic, anti-obesity, anti-inflammatory and anti-neoplastic actions. In every cancer tested, modulatory actions of fucoxanthinol on viability, cell-cycle arrest, apoptosis and members of the NF-κB pathway were more pronounced than that of fucoxanthin. Anti-proliferative and cancer preventing influences of fucoxanthin and fucoxanthinol are mediated through different signalling pathways, including the caspases, Bcl-2 proteins, MAPK, PI3K/Akt, JAK/STAT, AP-1, GADD45, and several other molecules that are involved in cell cycle arrest, apoptosis, anti-angiogenesis or inhibition of metastasis. In this review, we address the mechanisms of action of fucoxanthin and fucoxanthinol according to different types of cancers. Current findings suggest that these compounds could be effective for treatment and/or prevention of cancer development and aggressiveness.

Link 2: "Brown Seaweeds"
or Go To
http://rvaprostatecancersupport.org/PDF/1 13 21 Martin-2015-Fucoxanthin-and-its-metabolite-fuco.pdf

Source Website:
"Gambogic acid, a natural xanthone, has been reported to inhibit MDM2 at both the transcriptional and posttranslational levels and exerts anticancer activity in vitro and in vivo, regardless of the p53 status of the cells/tumors.62 "
Source of Garcinia:

Link 3: "Garcinia"
or Go To
https://www.iherb.com/pr/Now-Foods-Garcinia-1-000-mg-120-Tablets/55359

Source Website:
"Fucoxanthin (27), a natural carotenoid, inhibits cell growth and colony formation, induces cell cycle arrest at the G0/G1 phase, and leads to apoptosis in T24 bladder cancer cells. 109 Fucoxanthin inhibits the mortalin-p53 complex and reactivates mutant p53 in these cells, resulting in the upregulation of p21. The crude extract of turmeric (Curcuma longa) and its bioactive component, curcumin, have been found to induce apoptosis and autophagy in A431 epidermoid cancer cells, which express mutant p53 R273H.110 Both turmeric and curcumin induce macroautophagy, resulting in the degradation of mutant p53. (You know how I love Curcumin at 15 pills a day. And In the past i have dropped my PSa taking 3 pills of Fucoxanthin a day)
Source of Fucoidan:

Link 4: "Fucoidan"
or Go To
https://www.swansonvitamins.com/swanson-greenfoods-formulas-pure-maximum-strength-fucoidan-extract-500-mg-60-veg-caps

Source Website:
"Fucoxanthin (27), a natural carotenoid, inhibits cell growth and colony formation, induces cell cycle arrest at the G0/G1 phase, and leads to apoptosis in T24 bladder cancer cells.109 Fucoxanthin inhibits the mortalin-p53 complex and reactivates mutant p53 in these cells, resulting in the upregulation of p21. The crude extract of turmeric (Curcuma longa) and its bioactive component, curcumin, have been found to induce apoptosis and autophagy in A431 epidermoid cancer cells, which express mutant p53 R273H.110 Both turmeric and curcumin induce macroautophagy, resulting in the degradation of mutant p53. (you know how I love Curcumin at 15 pills a day. And In the past i have dropped my PSa taking 3 pills of Fucoxanthin a day)
Source of Fucoxanthin :

Link 5: "Fucoxanthin"
or Go To
hthttps://www.luckyvitamin.com/p-13164-garden-of-life-fucothin-concentrated-fucoxanthin-90-softgels?LanguageCode=EN&locale=en-US&as=nd&scid=scplp62303&sc_intid=62303&utm_campaign=LV-US-ShoppingCampaign-SmartShopping-TopBrands&gclid=Cj0KCQiArvX_BRCyARIsAKsnTxMvwU2DzLiiv7R0k_MN5p5-u3rSwruIrtEs07H5pXSwpTG6oFnb4LoaAmvNEALw_wcB

Difference Between Fucoidan and Fucoxanthin - Website Info:

Link 6: "Difference"
or Go To
https://www.differencebetween.com/difference-between-fucoidan-and-fucoxanthin/#:~:text=The%20key%20difference%20between%20fucoidan,brown%20algae%20and%20other%20heterokontshttps://www.luckyvitamin.com/p-13164-garden-of-life-fucothin-concentrated-fucoxanthin-90-softgels?LanguageCode=EN&locale=en-US&as=nd&scid=scplp62303&sc_intid=62303&utm_campaign=LV-US-ShoppingCampaign-SmartShopping-TopBrands&gclid=Cj0KCQiArvX_BRCyARIsAKsnTxMvwU2DzLiiv7R0k_MN5p5-u3rSwruIrtEs07H5pXSwpTG6oFnb4LoaAmvNEALw_wcB
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Us Too Warriors,

Vitamin K2

I have often recommended that members supplement with Vitamin K2 with their Vitamin D2 to prevent hardening of yours of Arteries and its attendant heart disease. I take 3 pills a day of Life Extension Super K with its Vitamin K2 present. The YouTube Video below discusses the need and uses of Vitamin K2 for your information.

Best
Peter

Abstract:

To See the Video - Click on the Link Below:

Link 1: "Vitamin K2"
or Go To
https://www.youtube.com/watch?v=BvGssM-X-Lg&feature=youtu.be
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Articles:

It Appears that Vitamin K2 can slow cancer especially bone Metastasis. Life extension has just put out a high dose Vitamin K2 pill with about 45 the dose of their Super Vitamin K2 that I have been taking for years. This may turn out to be a way to fight bone metastasis in prostate cancer! I am just beginning to investigate this stay tuned
See Below

ABSTRACT
Epidemiological studies have demonstrated a relationship between cancer incidence and dietary habits. Especially intake of certain essential nutrients like vitamins has been shown to be beneficial in experimental studies and some clinical trials. Vitamin K (VK) is an essential nutrient involved in the blood clotting cascade, and there are considerable experimental data demonstrating its potential anticancer activity in several cancer types including prostate cancer. Previous in vitro and in vivo studies have focused mainly on anti-oxidative effects as the underlying anticancer mechanism of VK. However, recent studies reveal that VK inhibits the growth of cancer cells through other mechanisms, including apoptosis, cell cycle arrest, autophagy, and modulation of various transcription factors such as Myc and Fos. In the present review, we focus on the anticancer effect of dietary VK and its analogs on prostate cancer, with an emphasis on the signaling pathways that are activated following exposure to these compounds. This review also highlights the potential of VK and its derivatives as an adjuvant treatment in combination with other vitamins or with chemotherapeutic drugs. Based on our recent results and a review of the existing literature, we present evidence that VK and its derivatives can potentially be explored as cancer therapy, especially for prostate cancer.

Link 2: "Vit K"
or Go To
http://rvaprostatecancersupport.org/PDF/1 13 21 Dasari-2017-Vitamin-k-and-its-analogs-potential (1).pdf

ABSTRACT
In recent years, several studies have shown that vitamin k2 (VK2) has anticancer activity in a variety of cancer cells. The antitumor effects of VK2 in prostate cancer are currently not known. In the present study, we sought to characterize the anticancer potential of VK2 in both androgen-dependent and -independent prostate cancer cells. Our investigations show that VK2 is able to suppress viability of androgen-dependent and androgen-independent prostate cancer cells via caspase-3 and -8 dependent apoptosis. We also show that VK2 treatment reduces androgen receptor expression and PSA secretion in androgen-dependent prostate cancer cells. Our results also implicate VK2 as a potential anti-inflammatory agent, as several inflammatory genes are downregulated in prostate cancer cells following treatment with VK2. Additionally, AKT and NF-kB levels in prostate cancer cells are reduced significantly when treated with VK2. These findings correlated with the results of the Boyden chamber and angiogenesis assay, as VK2 treatment reduced cell migration and angiogenesis potential of prostate cancer cells. Finally, in a nude mice model, VK2 administration resulted in significant inhibition of both androgen-dependent and androgen-independent tumor growth. Overall, our results suggest that VK2 may be a potential therapeutic agent in the treatment of prostate cancer.

Link 3: "Vit K"
or Go To
http://rvaprostatecancersupport.org/PDF/1 13 21 Samykutty-2013-Vitamin-k-a-naturally-occurring-men.pdf
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Us Too Warriors,

Cortisol and Health-related Quality of Life as Prognostic Indicators for Prostate Cancer
Risk in West African Black Men in Nigeria, Cameroon and the USA:
The CaPTC Cohort Study

Life stressed increase Cortisol which Grows PCa see attachments below. For those of you who have been members for a while will remember Jerry Deans leading several of our meetings to teach us on how tho lower stress by relaxing and breathing deeply while we repeated a montra to ourselves as we breathe deeply in and out with our eyes closed. I have been using this for about 14 years since Jerry first introduced our group to it. This produces a physiological process in our body called the "stress relaxation response". I have studied this Response and found that this can also be produced by a Life extension supplement extracted from green tea called "L-Theanine" ( Enhanced Stress Relaxation pills). I Have had my wife using these pills for years as she is very hyper and jumps if I walk into the room too Quietly.

Stress has been very bad for her fibromyalgia which I think my cancer diagnosis greatly exaggerated. We have only started to get a handle on it by her adding CBD hemp oil to treatment in the last year or two.

Read the attached paper below and figure out how you can reduce stress to slow your cancer.

Best
Peter

Abstract:

More Info - Click on the Link Below:

Link 1: "Cortisol"
or Go To
http://rvaprostatecancersupport.org/PDF/1 11 21 116-Article Text-1398-3-10-20210104.pdf
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Us Too Warriors,

50% Of Pca MEN Have The TMPRSS2-ERG Mutation – That I Have

The treatment that I found for my mutation by trial and error from research papers may work for you if you have this mutation (which 50% or more have as shown by several analysis from several gene analysis that show it is the most common mutation). It tends to make the cancer more aggressive. When the cancer is at early stages, Avodart(dutasteride = .5mg/day ) will be enough slow the PSA which work for me for 15 years after I had biochemical recurrence after my prostatectomy (and my PSA was less than 1.0 (actually at PSA = 0.3). it is still working for one of my brothers with this family germline mutation.

After your PSA goes above 1.0 while on dutasteride it (PSA) will start rising faster and faster and at this point you need to add Casodex(bicalutamide =150 mg/day) the androgen receptor blocker to drive your PSA down.

The two attached papers below explain how these drugs work to control the PSA - read them for your benefit.

Best
Peter

Abstract:

Role of Dutasteride in Pre-Clinical ETS Fusion-Positive Prostate Cancer Models

and

Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer

More Info - Click on the Links Below:

Link 1: "Dutasteride"
or Go To
http://rvaprostatecancersupport.org/PDF/1 6 21 22509_ftp.pdf

Link 2: "Estrogen-dependent"
or Go To
http://rvaprostatecancersupport.org/PDF/1 6 21 nihms272096.pdf
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Us Too Warriors,

Treatments for Anemia when you Have Prostate cancer?

I am trying to give one of my brothers advice to increase his Blood Hematocrit without causing other problems. He has lowered kidney function which is important in producing blood cells. There are drugs to stimulate blood cell formation like Procrit and Epo but they contribute to strokes and heart problems and Prostate cancer growth. and are only used for quality of life for PCa men on hospice.

His PCa seems to be slowed in growing by many of the things that I take and we have the same TMPRSS2-ERG fusion Gene so they seem to be working as his PSA with a prostate is only 1.4 at 82 years.

My expectation is that his low testosterone ~200 may be contributing to his poor kidney function and anemia. So I think he should check with his Doctors to see if he can get testosterone cream to rub on his body to raise his testosterone to 450 to 550. This should help his kidney function and reduce anemia. The concern is that the testosterone may increase his cancer growth but with a testosterone of 200 it is high enough to saturate his cancer cell so the increase would have little effect. But I would recommend he double his dose of Avodart or add proscar to his present dose of avodart whichever he can get his Doctor to Do? This will keep his Dihydrotestosterone low so as not stimulate PCa.

See the two websites attached for more information.

Best
Peter

Abstract:

Erythropoiesis-Stimulating Agents Recommended for Some Patients With Cancer and Anemia

and

Blood Disorders (Anemia, Leukopenia, and Thrombocytopenia)

More Info - Click on the Links Below:

Link 1: "Erythropoiesis-Stimulating"
or Go To
https://ascopost.com/issues/may-25-2019/erythropoiesis-stimulating-agents-recommended-for-some-patients-with-cancer-and-anemia/
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Link 2: "Blood Disorders"
or Go To
https://www.lifeextension.com/protocols/heart-circulatory/blood-disorders
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Us Too Warriors,

Therapeutic Potential of Leelamine, a Novel Inhibitor of Androgen Receptor and Castration-Resistant Prostate Cancer

See the link below for more information.

Best Holiday
Peter

Abstract:

Clinical management of castration-resistant prostate cancer (CRPC) resulting from androgen deprivation therapy remains challenging. CRPC is driven by aberrant activation of androgen receptor (AR) through mechanisms ranging from its amplification, mutation, post-translational modification, and expression of splice variants (e.g., AR-V7). Herein, we present experimental evidence for therapeutic vulnerability of CRPC to a novel phytochemical,leelamine (LLM), derived from pine tree bark. Exposure of human prostate cancer cell lines LNCaP (an androgen-responsive cell line with mutant AR), C4-2B (an androgen-insensitive variant of LNCaP), and 22Rv1 (a CRPC cell line with expression of AR-Vs), and a murine prostate cancer cell line Myc-CaP to plasma achievable concentrations of LLM resulted in ligand-dependent (LNCaP) and ligand-independent (22Rv1) growth inhibition in vitro that was accompanied by downregulation of mRNA and/or protein levels of full-length AR as well as its splice variants including AR-V7. LLM treatment resulted in apoptosis induction in the absence and presence of R1881. In silico modelling followed by luciferase reporter assay revealed a critical role for non-covalent interaction of LLM with Y739 in AR activity inhibition. Substitution of the amine group with an isothiocyanate functional moiety abolished AR and cell viability inhibition by LLM. Administration of LLM resulted in 22Rv1 xenograft growth suppression that was statistically insignificant but was associated with a significant decrease in Ki-67 expression, mitotic activity, expression of full-length AR and AR-V7 proteins, and secretion of prostate-specific antigen. The present study identifies a novel chemical scaffold for the treatment of CRPC.

More Info - Click on the Link Below:

Link: "Leelamine"
or Go To
http://rvaprostatecancersupport.org/PDF/1 1 21 Singh-2018-Therapeutic-potential-of-leelamine-.pdf
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Us Too Warriors,

Turmeric in Combination with Quercetin

One of the ways PCa progresses on ADT or on Androgen receptor blocking Mono Therapy like Casodex or in combined ADT and Xtandi is by the cancer increasing the number of Androgen receptors (This is caused making a bigger Sail so even low Testosterone grows the cancer).

I have recently read that testosterone in Turmeric in combination with quercetin helps to block this process. I have started to have some growth in my Casodex monotherapy so I added more Turmeric and Quercetin to my treatments to stop the growth.

Best Holiday
Peter

Abstract:

Cancer is a hyperproliferative disorder that is usually treated by chemotherapeutic agents that are toxic not only to tumor cells but also to normal cells, so these agents produce major side effects. In addition, these agents are highly expensive and thus not affordable for most. Moreover, such agents cannot be used for cancer prevention. Traditional medicines are generally free of the deleterious side effects and usually inexpensive. Curcumin, a component of turmeric (Curcuma longa), is one such agent that is safe, affordable, and efficacious. How curcumin kills tumor cells is the focus of this review. We show that curcumin modulates growth of tumor cells through regulation of multiple cell signaling pathways including cell proliferation pathway (cyclin D1, c-myc), cell survival pathway (Bcl-2, Bcl-xL, cFLIP, XIAP, c-IAP1), caspase activation pathway (caspase-8, 3, 9), tumor suppressor pathway (p53, p21) death receptor pathway (DR4, DR5), mitochondrial pathways, and protein kinase pathway (JNK, Akt, and AMPK). How curcumin selectively kills tumor cells, and not normal cells, is also described in detail.

More Info - Click on the Link Below:

Link: "Combination"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758121/
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Us Too Warriors,

Neem

Neem is my Latest addition to help my PCa Fight

Best Holiday
Peter

NEEM/AND ITS COMPONENTS AS EFFECTIVE AGENTS FOR PREVENTION, TREATMENT AND CELL DEATH, FOR PCA, AND OTHER CANCERS.

The 2 main components of Neem that are active against cancer, are Azadirachtin, and Nimbolia. I am doing below my research summarization. And for those that want to study these compounds and Neem can find lots to read in Pub Med, Science Direct et. al. and I do not copy and paste.

Usually Ethanolic extracts of Indian Neem Leaf are what are used in the study of the effects on cancer cell lines. Yes Prostate included. Natives of India have use the Neem Leaf for 400 years, and the local Herbalists, over many decades regularly treat cervical cancer with Neem Preparations.

More Info - Click on the Links Below:

Link 1: "Neem"
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/144946771/neem-and-its-components-as-effective-agents-for-prevention-treatment-and-cell-death-for-pca-and-other-cancers.#post-responses
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Link 2: "Gov-Link Neem"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682706/
*
Link 3: " Sloan Kettering Cancer Center-Link Neem"
or Go To
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/neem
*********************************************
Us Too Warriors,

Could chocolate or green tea fight Covid-19? NC State researchers think it's possible

I have been taking 9 pills/day of Super Green Tea Extract( lightly caffeinated) from Life Extension Inc for about 15 years for PCa as a strong antioxidant. (These pills are probably equal to 30 to 60 cups of tea/day). The website below from N.C. State Researchers suggest this is a good combination with Dark chocolate to fight Covid-19. It is a very enjoyable way to fight covid especially if your Brother has sent you a Dark Chocolate with Hazelnut bar as he did for Christmas (and if your favorite nuts are Hazel Nuts like me). Enjoy your holiday in good health,

I pray.

Peter

New research coming out of N.C. State says that certain foods, including dark chocolate and green tea, may be inhibitors to the virus that causes Covid-19.

This week, new research was published in Frontiers in Plant Sciencedetailing work from a team of plant biologists at N.C. State regarding how certain chemical compounds in food and beverages may interact with the virus. Researchers analyzed how compounds found in certain foods could bind to and block the function of a specific enzyme – or protease – in the virus, which could inhibit it in a number of ways including slowing its replication.

For Much More Info - Click on the Link Below:

Link: "Chocolate "
or Go To
https://www.bizjournals.com/triangle/news/2020/12/01/covid-diet-fight-virus-chocolate-green-tea-grapes.html
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Us Too Warriors,

Natural Health Healing like nasal lavage and gargle can fight getting and spreading

Check the website below about ways to help you.

Best Holiday
Peter

The Journal of the American Medical Association (JAMA) is among the most widely respected medical journals in the world. In July, it published a collaborative research paper looking at nasal irrigation and its hypothetical effects on the coronavirus. The analysis was written by scientists at the Washington University School of Medicine and Oregon Health & Science University.2

It was titled: Benefits and Safety of Nasal Saline Irrigations in a Pandemic—Washing COVID-19 Away.3

Can you actually “wash away” the coronavirus?

For Much More Info - Click on the Link Below:

Link: "Natural Health Healing "
or Go To
https://www.institutefornaturalhealing.com/issues/ih_october2020.html?bsft_eid=ada17c73-9711-0932-5e68-50c9fa120466&bsft_aaid=125df99d-f163-4437-b900-29fafdc6a7e6&utm_campaign=12-23-20-thc-dedicated-engagement-effort1&utm_source=blueshift&utm_medium=email&utm_content=12-23-20-thc-dedicated-engagement-effort1&bsft_clkid=f1a83a7e-0db8-4914-8149-2347b076c251&bsft_uid=0131f227-755f-4690-a6df-f7d7c78c0773&bsft_mid=97a3f152-5dda-4865-89cb-b7765259a20f&bsft_utid=0131f227-755f-4690-a6df-f7d7c78c0773-THCDED&bsft_link_id=9&bsft_mime_type=html&bsft_ek=2020-12-23T22%3A31%3A07Z&bsft_lx=5&bsft_tv=
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Us Too Warriors,

Prostate cancer regulator plays role in COVID-19, providing a promising treatment lead

The website below explains research showing How PCa treatment can block Covid -19 infection which I discussed in past emails !!

Best Holiday
Peter

By taking a lesson from prostate cancer, researchers now have a promising lead on a treatment for COVID-19. Two proteins, ACE2 and TMPRSS2, help the coronavirus gain entry and replicate within cells. TMPRSS2 is well-known to Arul Chinnaiyan, M.D., Ph.D. His lab discovered that TMPRSS2 fuses with the ETS gene to drive more than half of all prostate cancers. They also knew that TMPRSS2 was regulated by the androgen receptor.

More Info - Click on the Link Below:

Link: "COVID-19"
or Go To
https://medicalxpress.com/news/2020-12-prostate-cancer-role-covid-treatment.html
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Us Too Warriors,

New Scan Finds Prostate Cancer Cells Hiding in the Body

After doctors found cancer in Dr. Mark Samberg’s prostate last spring, the 70-year-old retired urologist prepared to have his prostate removed. He knew that the surgery would cure him, assuming the cancer was confined to the organ.

But his doctors had a nagging concern — the cancer cells seen on the biopsy were aggressive and may already have escaped from his prostate. If so, the operation would not cure him. The problem for Dr. Samberg, and for many men with aggressive prostate cancer, was this: If there are cancer cells outside the prostate, how can they be found?

Now the Food and Drug Administration has approved a test that can locate prostate cancer cells wherever they are. Exuberant cancer specialists said the test would alter treatment for patients nationwide.

Best Holiday
Peter

More Info - Click on the Link Below:

Link: "Hiding"
or Go To
https://www.nytimes.com/2020/12/16/health/prostate-cancer-scan.html?referringSource=articleShare
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Us Too Warriors,

Food and Supplement study in FDA journal on natural treatments to Prevent Metastasis in many Cancers & PCa

My PSA as of October was though very low (0.048). But, it was doubling every 5 Months and at that rate it does not take long to get high. So I added 4 more natural PCa inhibitors and on Dec 16th the doubling time had increased to 12 months by my blood test - My Christmas present came early for Christmas. Look at the natural agents in the attached paper and see if you can give yourself a Present and as you know I am always looking for presents.

Best Holiday
Peter

More Info - Click on the Link Below:

Link: "Food and Supplement Study"
or Go To
http://rvaprostatecancersupport.org/PDF/12 21 20 1-s2.0-S102194981830084X-main.pdf

Us Too Warriors,

Radiation Therapy Failure and Radiosensitization of Prostate Cancer

The paper attached below suggests Drugs and Supplements that may prevent radiation failure produced by the biomarkers.

Best
Peter

Review Article
Factors Implicated in Radiation Therapy Failure and Radiosensitization of Prostate Cancer

Helmut Bonkhoff

Copyright © 2012 Helmut Bonkhoff. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Tissue markers may be helpful in enhancing prediction of radiation therapy (RT) failure of prostate cancer (PCa). Among the various biomarkers tested in Phase III randomized trials conducted by the Radiation Therapy Oncology Group, p16, Ki-67, MDM2, COX-2, and PKA yielded the most robust data in predicting RT failure. Other pathways involved in RT failure are also implicated in the development of castration-resistant PCa, including the hypersensitive androgen receptor, EGFR, VEGF-R, and PI3K/Akt. Most of them are detectable in PCa tissue even at the time of initial diagnosis. Emerging evidence suggests that RT failure of PCa results from a multifactorial and heterogeneous disease process. A number of tissue markers are available to identify patients at high risk to fail RT. Some of these markers have the promise to be targeted by drugs currently available to enhance the efficacy of RT and delay disease progression.

More Info - Click on the Link Below:

Link: "Therapy Failure"
or Go To
http://rvaprostatecancersupport.org/PDF/12 16 20 593241.pdf

Us Too Warriors,

Targeting transcriptional regulation of SARS-CoV-2entry factors ACE2 and TMPRSS2Y

See paper attached below to fight Covid and PCa.

Best
Peter

Contributed by Arul M. Chinnaiyan, November 18, 2020 (sent for review October 16, 2020; reviewed by William L. Dahut and Nicholas Nickols)

Helmut Bonkhoff

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, employs two key host proteins to gain entry and replicate within cells, angiotensin-converting enzyme 2 (ACE2) and the cell surface transmembrane protease serine 2 (TMPRSS2). TMPRSS2 was first characterized as an androgenregulated gene in the prostate. Supporting a role for sex hormones, males relative to females are disproportionately affected by COVID19 in terms of mortality and morbidity. Several studies, including one employing a large epidemiological cohort, suggested that blocking androgen signaling is protective against COVID-19. Here, we demonstrate that androgens regulate the expression of ACE2, TMPRSS2, and androgen receptor (AR) in subsets of lung epithelial cells. AR levels are markedly elevated in males relative to females greater than 70 y of age. In males greater than 70 y old, smoking was associated with elevated levels of AR and ACE2 in lung epithelial cells. Transcriptional repression of the AR enhanceosome with AR or bromodomain and extraterminal domain (BET) antagonists inhibited SARS-CoV-2 infection in vitro. Taken together, these studies support further investigation of transcriptional inhibition of

More Info - Click on the Link Below:

Link: "SARS-CoV-2"
or Go To
http://rvaprostatecancersupport.org/PDF/12 16 20 2021450118.full-1.pdf

Us Too Warriors,

Melatonin

Cleveland Clinic Identifies Melatonin as COVID-19 Treatment

By Joseph Mercola
December 3, 2020 Updated: December 6, 2020
Print

Melatonin is a hormone synthesized in your pineal gland and many other organs. While it is most well-known as a natural sleep regulator, it also has many other important functions.
Melatonin Is a potent antioxidant with the rare ability to enter your mitochondria, where it helps “prevent mitochondrial impairment, energy failure, and apoptosis of mitochondria damaged by oxidation,” notes a 2007 review published in Frontiers in Bioscience. It also helps recharge glutathione, and glutathione deficiency has been linked to COVID-19 severity

Research has also found that melatonin is important in several other ways:
It plays an important role in cancer prevention
Is important for brain, cardiovascular, and gastrointestinal health
Boosts immune function in a variety of ways
May improve the treatment of certain bacterial diseases, including tuberculosis
Helps quell inflammation
May prevent or improve autoimmune diseases, including Type 1 diabetes
Is an important energy hormone that can influence your energy level
Helps regulate gene expression via a series of enzymes
Has anticonvulsant and antiexcitotoxic properties
Best
Peter

More Info - Click on the Link Below:

Link: "Melatonin"
or Go To
https://www.theepochtimes.com/cleveland-clinic-identifies-melatonin-as-covid-19-treatment_3592407.html

Us Too Warriors,

Natural-Aromatase-Inhibitors

I have been trying to block my Alpha estrogen receptor as with my use of Casodex I produce high testosterone which Aromatases in my blood from diet etc can turn the testosterone into estrogen which if it bonds to my Alpha estrogen receptor can grow the cancer. So I take Aromatase inhibitors to block estrogen formation. My list of twelve Aromatases is listed below the abstract that follows.

Xu Z, Wang Y, Xiao ZG, et al. Nuclear receptor ERRα and transcription factor ERG form a reciprocal loop in the regulation of TMPRSS2:ERG fusion gene in prostate cancer. Oncogene. 2018; 37(48):6259-6274 [PubMed] Article available free on PMC after 31/12/2019 Related Publications

The TMPRSS2:ERG (T:E) fusion gene is generally believed to be mainly regulated by the activated androgen receptor (AR) signaling in androgen-dependent prostate cancer. However, its persistent expression in castration-resistant and neuroendocrine prostate cancers implies that other transcription factors might also regulate its expression. Here, we showed that up-regulation of nuclear receptor estrogen-related receptor alpha (ERRα) was closely associated with the oncogenic transcription factor ERG expression in prostate cancer, and their increased coexpression patterns were closely associated with high Gleason scores and metastasis in patients. Both ERRα and ERG exhibited a positive expression correlation in a castration-resistant prostate cancer (CRPC) xenograft model VCaP-CRPC. We showed that ERRα could directly transactivate T:E fusion gene in both AR-positive and -negative prostate cancer cells via both ERR-binding element- and AR-binding element-dependent manners. Ectopic T:E expression under ERRα regulation could promote both in vitro invasion and in vivo metastasis capacities of AR-negative prostatic cells. Intriguingly, ERG expressed by the T:E fusion could also transactivate the ERRα (ESRRA) gene. Hereby, ERRα and ERG can synergistically regulate each other and form a reciprocal regulatory loop to promote the advanced growth of prostate cancer. Inhibition of ERRα activity by ERRα inverse agonist could suppress T:E expression in prostate cancer cells, implicating that targeting ERRα could be a potential therapeutic strategy for treating the aggressive T:E-positive prostate cancer.

Check this website==> https://www.canceractive.com/article/natural-aromatase-inhibitors
Follow are some of the Aromatase inhibitors I know I am taking. I expect that some of the other supplements are also inhibitor too
1. Femara - prescription to reduce breast growth and hot flashes - 1 pill/day
2. Foti ( also called emodin) 3/day
3. Chrysin 3/d
4 Grape seed Extract 3/d
5 DIM 3/d
6. Apigenin 3/d
7 Indole 3- Carbinol =I3C 3/d
8. Quercetin 3/d
9. Luteolin 3/d
10. Myricetin 3/d
11. Green tea 9/d
12. Curcumin 12/d

Best
Peter

More Info - Click on the Link Below:

Link: "Natural-Aromatase-Inhibitors"
or Go To
https://www.canceractive.com/article/natural-aromatase-inhibitors

Us Too Warriors,

Development of a stress response therapy targeting aggressive prostate cancer

Oncogenic lesions up-regulate bioenergetically demanding cellular processes, such as protein synthesis, to drive cancer cell growth and continued proliferation. However, the hijacking of these key processes by oncogenic pathways imposes onerous cell stress that must be mitigated by adaptive responses for cell survival. The mechanism by which these adaptive responses are established, their functional consequences for tumor development, and their implications for therapeutic interventions remain largely unknown. Using murine and humanized models of prostate cancer (PCa), we show that one of the three branches of the unfolded protein response is selectively activated in advanced PCa. This adaptive response activates the phosphorylation of the eukaryotic initiation factor 2– (P-eIF2) to reset global protein synthesis to a level that fosters aggressive tumor development and is a marker of poor patient survival upon the acquisition of multiple oncogenic lesions. Using patient-derived xenograft models and an inhibitor of P-eIF2 activity, ISRIB, our data show that targeting this adaptive brake for protein synthesis selectively triggers cytotoxicity against aggressive metastatic PCa, a disease for which presently there is no cure.

Also, Link 2

Drug Reverses Age-Related Mental Decline Within Days
Rapid Rejuvenation of Mental Faculties in Aged Mice Implicates Reversible Physiological ‘Blockage’ Behind Age-Related Cognitive Losses
Best
Peter

More Info - Click on the Link Below:

Link: "Stress Response Therapy"
or Go To
http://rvaprostatecancersupport.org/PDF/121 11 20 eaar2036.full.pdf

Drug Reverses Age-Related Mental Decline Within Days

Link: "Mental Faculties"
or Go To
https://www.ucsf.edu/news/2020/12/419201/drug-reverses-age-related-mental-decline-within-days

Us Too Warriors,

Metformin

I have been using Metformin to fight my cancer for about 5 years after Adovart stopped controlling the cancer growth. It reduces the sugar in the blood and is commonly used to help people with diabetes. It is important to have a glucose level in the higher 70's to be able to take Metformin. My glucose has been between about 86 to 93. If Glucose goes below 70 there is the chance that the person may pass out. But using metformin reduces inflammation which is a problem for cancer and covid. I mistakenly took double the maximum dose of Metformin when my doctor or pharmacy changed my pills from 500 mg to 1000mg pills without telling me. It caused me to throw up for several days until I read the label on the bottle.

Also, High dose Vitamin D3 reduces Covid deaths by 75% found in Spanish clinical analysis. High dose Vitamin D3 also helps men with advanced PCa survive too. A dose of 8,866 IU of vitamin D3 is what our group averaged when I had them quizzed. This is a good number to start with and then after 3 Months get a 25 OH vitamin D blood test to see if your blood level is between 60+ to 80 ng/ml. The variation of vitamin d absorption in the gut can be as much a factor of 7X that is why you need blood tests to know your number. I take about 17,000 IU of Vitamin D to get my level at 100ng/ml. In the winter, You should bump up Vitamin D in the winter when the Sun is low so the UV is absorbed before reaching the earth. Best
Peter

Diabetes Drug May Decrease COVID-19 Death Risk In Women

A recent study found an association between metformin and a significantly reduced mortality risk in women with type 2 diabetes or obesity who were hospitalized with COVID-19.

More Info - Click on the Link Below:

Link: "Metformin"
or Go To
http://rvaprostatecancersupport.org/PDF/12 11 20 Metformin.pdf

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Us Too Warriors,

"Association of Presalvage Radiotherapy" and Antiandrogen Therapy

Check these websites. Best
Peter

Association of Presalvage Radiotherapy PSA Levels After Prostatectomy With Outcomes of Long-term Antiandrogen Therapy in Men With Prostate Cancer.

Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer

More Info - Click on the Links Below:

Link: "Presalvage"
or Go To
https://pubmed.ncbi.nlm.nih.gov/32215583/

Link: "Antiandrogen"
or Go To
https://pubmed.ncbi.nlm.nih.gov/28146658/

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Us Too Warriors,

How to handle a Relapse after treatment for prostate cancer.

Check this out if you are facing BCR like I have for the last 21 years. Best
Peter

Four key questions

If your PSA rises after prostate cancer treatment, answering four key questions will help you and your doctor determine next steps:

What were your risk characteristics, such as Gleason score, PSA, and cancer stage, at the time of diagnosis? (See Table 1.)
What type of treatment did you have? That will help determine your next treatment options.
How long has it been since you underwent initial therapy for prostate cancer? This helps indicate how aggressive follow-up treatment needs to be.
How fast is your PSA rising, as determined from several evaluations?

More Info - Click on the Link Below:

Link: "Relapse"
or Go To
https://www.health.harvard.edu/blog/how-to-handle-a-relapse-after-treatment-for-prostate-cancer-2009031122

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Us Too Warriors,

Bicalutamide and Metformin

43% of the men (3) getting Bicalutamide and Metformin had Undetectable PSA like I do (PSA less than 0.1) at 32 weeks of use. Best
Peter More Info - Click on the Link Below:

Link: "Undetectable"
or Go To
https://ascopubs.org/doi/abs/10.1200/JCO.2020.38.6_suppl.85

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Us Too Warriors,

Imaging Technology

Topic: jinxing Yu's Zoom Meeting "How modern imaging technology helps patients who are under active surveillance, status post prostatectomy or radiation treatment?"

Best
Peter

Abstract:

How does modern imaging technology help patients who are under active surveillance, post prostatectomy or post radiation?

Jinxing Yu, MD
Professor of Radiology & Surgery
Director of Oncologic and Prostate Imaging
Department of Radiology
Virginia Commonwealth University Health

More Info - Click on the Link Below To See the Power Point Presentation Notes:

Link: "Power Point"
or Go To
http://rvaprostatecancersupport.org/PDF/11 22 20 Prostate Talk for prostate cancer supporting group 2020 (1).pdf

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Us Too Warriors,

piperlongumine

I am adding this supplement to my long list. See Website & Paper attached below for info.

Best
Peter

Abstract:

BACKGROUND:
—Elevated NF-κB activity has been previously demonstrated in prostate cancercell lines as hormone-independent or metastatic characteristics develop. We look at the effects of piperlongumine (PL), a biologically active alkaloid/amide present in piper longum plant, on theNF-κB pathway in androgen-independent prostate cancer cells.

METHODS:
—NF-κB activity was evaluated using Luciferase reporter assays and Western blotanalysis of p50 and p65 nuclear translocation. IL-6, IL-8, and MMP-9 levels were assessed usingELISA. Cellular adhesion and invasiveness properties of prostate cancer cells treated with PLwere also assessed.

RESULTS:
—NF-κB DNA-binding activity was directly down-regulated with increasingconcentrations of PL, along with decreased nuclear translocation of p50 and p65 subunits.Expression of IL-6, IL-8, MMP-9, and ICAM-1 was attenuated, and a decrease of cell-to-matrixadhesion and invasiveness properties of prostate cancer cells were observed.

CONCLUSIONS:
—PL-mediated inhibition of NF-κB activity decreases aggressive growthcharacteristics of prostate cancer cells in vitro.

More Info - Click on the Links Below:

Link: "Piperlongumine"
or Go To
http://rvaprostatecancersupport.org/PDF/11 21 20 nihms580665 (1).pdf
*
Link: "Purchase"
or Go To
https://bixabotanical.com/products/piper-longum-1?utm_medium=cpc&utm_source=google&utm_campaign=Google%20Shopping&utm_campaign=gs-2020-03-12&utm_source=google&utm_medium=smart_campaign&gclid=EAIaIQobChMI6N2hyKuU7QIVFK7ICh0R8QiTEAQYAyABEgL5X_D_BwE

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Us Too Warriors,

mCRPC: Cabazitaxel tops enzalutamide and abiraterone in quality of life outcomes

Key clinical point: In previously treated patients with metastatic castration-resistant prostate cancer (mCRPC), cabazitaxel significantly improved pain response, prolonged time to pain progression and reduced the risk of symptomatic skeletal events vs abiraterone or enzalutamide.

Best
Peter

More Info - Click on the Link Below:

Link: "Pain"
or Go To
https://www.mdedge.com/fedprac/clinical-edge/summary/prostate-cancer/mcrpc-cabazitaxel-tops-enzalutamide-and-abiraterone?group_type=week

*
Us Too Warriors,

RVA Us Too - Covid treatment/ prevention -Zn, Vitamin C & D3,Nitric Oxide etc

I am sure you are aware that having PCa puts us plus the age most of us Carry puts us in a higher mortality range if we catch Covid.

I calculate my chance of Mortality at 40%,and my brothers at 55%and 80%.

These are the % Numbers if we were not taking things to mitigate the infection.

These are the agents I and my brothers are using plus a new anti- depressiant agent studied at U of Va discussed below : High doses Zn, Vitamins C & D3, Nitric Oxide, Brown Seaweed, Lactoferrin, Guafenesin and see far below antidepressant fluvoxamine.

See below for information

Best
Peter

Click on the Link Below:

Link: "Covid"
or Go To
https://neurosciencenews.com/antidepressant-coronavirus-17272/

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Us Too Warriors,

Fight Multiple Cancers

This is a possible path to fight multiple cancers including PCa which I am investigating. See Attachments.
See below for information

Best
Peter

Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways :

Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells

Click on the Links Below:

Link: "Benzimidazoles"
or Go To
http://rvaprostatecancersupport.org/PDF/11 12 20 Benzimidazoles.pdf
*
Link: "Fenbendazole"
or Go To
http://rvaprostatecancersupport.org/PDF/11 12 20 Fenbendazole.pdf

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Us Too Warriors,

Cellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications

This long Paper 132 paper analyzes out how mutation changes as PCa progresses. I think it may have answers if you can find them for your cancers. It will take a lot of digging to relate to your gene analysis.

See below for information

Best
Peter

Abstract: :
Prostate cancer is the most frequent nonskin cancer and second most common cause of cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with many patients exhibiting an aggressive disease with progression, metastasis, and other patients showing an indolent disease with low tendency to progression. Three stages of development of human prostate tumors have been identified: intraepithelial neoplasia, adenocarcinoma androgen-dependent, and adenocarcinoma androgen-independent or castration-resistant. Advances in molecular technologies have provided a very rapid progress in our understanding of the genomic events responsible for the initial development and progression of prostate cancer. These studies have shown that prostate cancer genome displays a relatively low mutation rate compared with other cancers and few chromosomal loss or gains. The ensemble of these molecular studies has led to suggest the existence of two main molecular groups of prostate cancers: one characterized by the presence of ERG rearrangements (~50% of prostate cancers harbor recurrent gene fusions involving ETS transcription factors, fusing the 50 untranslated region of the androgen-regulated gene TMPRSS2 to nearly the coding sequence of the ETS family transcription factor ERG) and features of chemoplexy (complex gene rearrangements developing from a coordinated and simultaneous molecular event), and a second one characterized by the absence of ERG rearrangements and by the frequent mutations in the E3 ubiquitin ligase adapter SPOP and/or deletion of CDH1, a chromatin remodeling factor, and interchromosomal rearrangements and SPOP mutations are early events during prostate cancer development. During disease progression, genomic and epigenomic abnormalities accrued and converged on prostate cancer pathways, leading to a highly heterogeneous transcriptomic landscape, characterized by a hyperactive androgen receptor signaling axis.

Click on the Link Below:

Link: "Mutation Changes"
or Go To
http://rvaprostatecancersupport.org/PDF/11 5 20 PCa-Jerry Pten P53 TMPRSS2-ERG Spink1 Cellular.pdf

*
Us Too Warriors,

Cannabinoids

Another armamentarium I will add to my present treatment. See blog & paper below for your information. CBD oil has made my wife a new woman! by helping her with sleep which has mitigated her body pains.

See below for information

Best
Peter

BACKGROUND AND PURPOSE:
Cannabinoid receptor activation induces prostate carcinoma cell (PCC) apoptosis, but cannabinoids other than D9 -tetrahydrocannabinol (THC), which lack potency at cannabinoid receptors, have not been investigated. Some of these compounds antagonize transient receptor potential melastatin type-8 (TRPM8) channels, the expression of which is necessary for androgen receptor (AR)-dependent PCC survival.

Click on the Links Below:

Link: "Paper"
or Go To
http://rvaprostatecancersupport.org/PDF/11 5 20 De-petrocellis-2013-Non-thc-cannabinoids-inhibit-prosta.pdf

Link: "Blog"
or Go To
http://rvaprostatecancersupport.org/PDF/11 5 20 Blog follows.pdf

*
Us Too Warriors,

Key Genes in Prostate Cancer Progression: Role of MDM2, PTEN, and TMPRSS2-ERG Fusions

This will help all understand why gene testing can help. See below.

Best
Peter

Abstract

In recent years, multiple genes or their protein products have been linked to initiation and progression of prostate cancer. Such genes include TMPRSS2, ERG, PTEN, and MDM2. This chapter discusses the pathological roles as well as the potential diagnos‐ tic and therapeutic applications of these genes that are highly expressed in prostate cancer when compared to other cancer types. The presence of these genes and related defects are linked to growth, progression, metastasis, invasiveness and resistance in prostate cancers. While knowledge related to TMPRSS2, ERG, and PTEN have been accumulating in the last two decades, the prometastatic role of MDM2 has been emerging in the last few years and revealing important functions related to prostate cancer progression.

To See the Study:

Click on the Link:

Link: "Study"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 20 10.5772_64337 (1).pdf

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Us Too Warriors,

Vitamin D

Frailty is an issue all of us may face as we age if we have success fighting PCa that is contributed to by ADT and Chemo drugs.

I have discussed the Need for Vitamin D, Vitamin K2, CoQ10, Magnesium, Nitric Oxide Booster and to keep muscle, bone and exercise to keep our body working. See website below but like most Medical papers on vitamin D3 level their high level is low (= 4000IU). The average of our group (50 men responding) in 2011 was = 8666IU. The only way to know if you are taking a good amount is a 25 OH Vitamin D3 blood test. It ideally would be at least 65 to 80ng/ml of blood. I keep my and my wife's level at 100 ng/ml in our blood. I take 15,000 IU and My wife takes 10,000 IU for us to have the same amount in our blood (100ng/ml). My gene analysis shows that I only absorb only 60%. I take this high dose in the hope this will allow me to play soccer with my Buddies when Covid is over and soccer goals like I did last fall. Website below:

Best
Peter

To See the Website below:

Click on the Link:
Link: "Vitamin D"
or Go To
https://www.medicalnewstoday.com/articles/very-high-dosages-of-vitamin-d-may-delay-frailty-in-old-age?utm_source=newsletter&utm_medium=email&utm_campaign=MNT%20Daily%2
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Us Too Warriors,

Natural Products ( Flavanoids $ Drugs) that inhibit Covid and PCa from binding energies by computer molecular modeling calculations

The attached Papers suggest natural products that may bind to TMPRSS2 protease proteins to fight Covid and PCa. I had projects in dentistry about bone mineralization using molecular modeling about 25 years ago so I know it is very complex. The simplified way to look at it is:"the more negative the sum of all the binding energies among the natural products and TMPRSS2; the stronger the bond so that it (the bound natural product molecules) will interfere with TMPRSS2, stopping the Covid virus from entering our cells or the growth of PCa. These natural molecules found in food or supplements (Neohesperidin, Myricitrin, Quercitrin, Naringin, Icariin, and Ambroxol) were found to work against the TMPRSS2 protein in the paper . You will have to search for these supplements as I will to find sources.

These following drugs also block TMPRSS2 proteins by binding to them; Camostat, Bromhexine and Guaifenesin. Camostat is used in Japan for pancreatitis. Bromhexane is available overseas in cough medicines as I discussed in another recent email. Guaifenesin is found in American over-the- counter Cough/Mucus relieving medicines (Easiest to get at a drugstore). Do not use any cold/cough medicine that contains DM==>Dextromethorphan which is bad for prostate ( cancer/ enlargement). These cough relief agents release TMPRSS2 from our throat and chest so they can be spit out to excrete them form body so the can do not harm.See below for the paper.
Best
Peter

To See the paper below:

Click on the 3 Links:
Link 1 "Covid"
or Go To
http://rvaprostatecancersupport.org/PDF/10 27 20 PCa-TMPRSS2 natural product inhibitors for PCa and Covid.pdf
*

Link 2 "Anti-TMPRSS2"
or Go To
http://rvaprostatecancersupport.org/PDF/10 27 20 tbsd_a_1798813_sm6268.pdf
*

Link 3 "Natural Poducts"
or Go To
https://www.tandfonline.com/doi/pdf/10.1080/07391102.2020.1798813?needAccess=true&
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Us Too Warriors,

The Androgen-Regulated Protease TMPRSS2

This is an over the counter used in tablets and Cough syrups available in many countries overseas - not in the USA. It rids the throat and lungs of TMPRSS2 proteins that initiate Covid damage there. It also suppresses PCa growth by blocking TMPRSS2-ERG growth promoting PCa Mutation formation by reducing TMPRSS2 proteins. This may be beneficial for covid and PCa but if you have liver or Lung issues you will need to be careful to limit the amount used and check these organs with blood tests to cause no harm.

The Androgen-Regulated Protease TMPRSS2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis
Best
Peter

To See the paper below:

Click on the Link:
"Therapeutic Implications"
or Go To
http://rvaprostatecancersupport.org/PDF/10 27 20 Lucas-2014.pdf
*
Us Too Warriors,

Metastasis

The research website below suggest that men as they progress to Metastasis may develop this mutation and be less responsive to Chemo.

TMPRSS2-ERG in Blood and Docetaxel Resistance in Metastatic Castration-resistant Prostate Cancer

See website below for more information.

Best
Peter

To See the Website below:

Click on the Link:
"Metastasis"
or Go To
https://pubmed.ncbi.nlm.nih.gov/26948395/
*
Us Too Warriors,

Casodex and Avodart to Control PSA

If you are on Casodex and Avodart to control your PSA after primary treatment - It may stop working after several years (at least then stopping the Casodex may work again for 20 to 50% of the men). We have one member who started to have a doubling time of one month after being on casodex that shocked his PSA to .04 but then it started to double in One month feeding on his Casodex. This suggests his cancer is really really feeding on the casodex. He stopped the Casodex and has been in remission for 14 years now!!!

See website below for more information - This is my next treatment if my PSA increases rapidly.

Best
Peter

To See the Website below:

Click on the Link:
"Control"
or Go To
https://csn.cancer.org/node/151359
*
Us Too Warriors,

Cellular and Molecular Mechanisms Underlying Prostate Cancer Development:Therapeutic Implications

Look at pages 46,47 and 49 for the SPINK1 mutation. (most important for African Americans)

Look at pages 20-23 on the relationship of TMPRSS2-ERG are related to P53 and P10 mutations. best Peter (Most important for Caucasin Americans)

Other pages may also be scanned to find other places for these mutations as well as looking at the references for more detail.
Best
Peter

To See the paper below:

Click on the Link:
"Therapeutic Implications"
or Go To
http://rvaprostatecancersupport.org/PDF/10 17 20 medicines-06-00082 (2).pdf

Us Too Warriors,

A Must Read - Testosterone Metabolism and Prostate Cancer.

Following One line from the paper explains my successful treatment!!!!

"The existence of mAR and iAR suggest novel therapies. For example Casodex knocks out iAR but not mAR thus a combination of high T plus Casodex (or T plus Casodex plus Proscar(" + or Dutasteride PCMoon") might be effective." See [Friedman comment].

Friedman summarized this protocol in this [AMNI table].
Best
Peter

In this post we discuss theories of testosterone metabolism as it relates to prostate cancer. The research discussed here involves, in part, theories which, while based on scientific studies, still require additional investigation in order to establish their validity in a medical context. We will primarily rely on the four pathway model found in Endotext, an online endocrinology textbook, and further modelling efforts based on the highly accessed 2007 [PMID: 17678531] [Full text] and 2005 [PMID: 15777479] [Full Text] papers by Friedman in the journal: Theoretical Biology and Medical Modelling.

[Note that since this page was written Ed Friedman has published a book entitled "The New Testosterone Treatment: How You and Your Doctor Can Fight Breast Cancer, Prostate Cancer, and Alzheimer's". This book was just published so I have not seen it nor is the information below based on it. June 2013]

We start by discussing two naive single pathway models that likely correspond to what many believe to be the case but are too limited to give sufficiently complete understanding of the biochemical dynamics. To overcome this limitation, we then expand the single pathway model to a four pathway model. This is followed by a discussion of the androgen and estrogen receptors that form key components of the four pathway model. To this we discuss a further layer involving certain apoptotic and anti-apoptotic proteins. (Apoptotic proteins cause cancer cells to be killed, which is desirable, whereas anti-apoptotic proteins protect cancer cells which is undesirable.)

To See the paper below:

Click on the Link:
"Testosterone Metabolism and Prostate Cancer"
or Go To
https://palpable-prostate.blogspot.com/2008/02/testosterone-metabolism-and-prostate.html?fbclid=IwAR1BQto_SdyzRgjtGfxEaz0ZGTmcD6Gf8T4AyuwVqJZrp3jYdIWHoOyu4VY
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Us Too Warriors,

Garcinia Cambogia

The attached paper suggesting Garcinia Cambogia as a supplement to fight these PCa mutations is below
Gambogic Acid Induces Cell Apoptosis and Inhibits MAPK Pathway in PTEN-/-/p53-/- Prostate Cancer Cells In Vitro and Ex Vivo

Warning:
It appears that too much Garcinia Cambogia (more than160 mg /day) may lower kidney function and liver function. I do not have mutations in P10 or P53 so I am going to limit my Garcinia Cambogia pill intake to 80 mg/day. If you decide to use this supplement, I would suggest that you check your kidney and liver functions before you start these pills and after you have used them for six weeks check again to see they do no harm. If were you I would limit my intake to 80 mg of Garcinia Cambogia unless I had one of the bad mutations P10 or P53 negative and I would then up my intake to only 160 mg (2 of the Swanson pills/day) after I had used 1 pill and check it for 6 weeks to show it was no harm and then after 6 weeks on 2 pills I would check kidney and liver functions again. These pills are supposed to be for weight loss. Remember that excess fat and sugar and weight are bad for kidney and liver function as well as cancer.
Best
Peter

To See the paper below:

Click on the Link:
"Garcinia Cambogia"
or Go To
http://rvaprostatecancersupport.org/PDF/10 11 20 Pan2018_Article_GambogicAcidInducesCellApoptos.pdf
*
Can be Purchased at
"Purchase"
or Go To
https://www.amazon.com/Swanson-Garcinia-Cambogia-Milligrams-Capsules/dp/B00F5VV6B6/ref=sr_1_6?crid=1WL0O8WO2WLTM&dchild=1&keywords=garcinia+cambogia+swanson&qid=1602454659&sprefix=Garcinia+Cambogia+Swan%2Caps%2C138&sr=8-6
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Us Too Warriors,

Statin

I recently had my GP prescribe Pravastatin (40mg/d) which is a hydrophilic statin and I started to take Red rice yeast from Swanson Inc (SWU991) that contains a small amount of natural lipophilic statin at 3 pills/d. They lowered my LDL and raised my HDL and my kidney function significantly improved. TMG (From LEF) can increase kidney function also by lowering Homocysteine which I use from Swanson, Inc. See the Link attached below for more info.
Best
Peter

To See the paper below:

Click on the Link:
"Statin"
or Go To
http://rvaprostatecancersupport.org/PDF/10 11 20 Wang-2016-Statin-use-and-mortality-of-patient.pdf
*
Us Too Warriors,

FoTi

I have been taking Emodin = FoTi = Pterostilbene for about 14 years. I talked to Dr. Meyers about them in 2008 he warned me about taking them so I tripled down and took more. He had studied them and thought them a poison . I reasoned that they might poison my cancer. Here I am in remission still taking them for 14+ years later.
You decide for yourself.

Best
Peter

See paper attached below.
To see the Paper:
Click on the Link:
"FoTi"
or Go To
http://rvaprostatecancersupport.org/PDF/10 10 20 Lin-2012-Activation-of-ampk-by-pterostilbene.pdf
*
Us Too Warriors,

Nuclear Exclusion of the Androgen Receptor by Melatonin

My dose of 40 mg before bedtime is the level recommended to fight cancers and 3 mg per night is more like the value used to improve sleep.
Best
Peter

Abstract:
Androgen receptors (AR) play a crucial role in androgen-mediated processes and prostate cancer progression. The pineal hormone melatonin attenuates the androgen-dependent growth of benign and cancer prostate epithelial cells in vitro and may reverse clinical resistance to androgen ablation therapy in patients progressing on gonadotropin releasing hormone (GnRH) analogue. Where along the AR cascade does melatonin act remains to be determined. The effects of melatonin on AR localization, level and activity were assessed using androgen-insensitive prostate carcinoma PC3 cells stably transfected with a wild-type AR-expressing vector (PC3-AR).AR was localized to the PC3-AR cell nucleus in the absence of dihydrotestosterone (DHT). Melatonin caused a robust exclusion of the AR from the cell nucleus to the cytoplasm. The nuclear export inhibitor, leptomycin B prevented this process. The exclusion was selective since melatonin had no such effect on the nuclear localization of estrogen receptors alpha (ERalpha) in these cells. Melatonin also caused nuclear exclusion of the AR in the presence of DHT. In addition, it attenuated androgen induced reporter gene activity in PC3 cells co-transfected with the human AR and AR reporter plasmids. Elevated androgen concentrations counteracted melatonin's effects. Melatonin did not decrease AR level or androgen binding in the cells. The nuclear localization of the AR is a hallmark of its cellular activity. These data point to AR nuclear exclusion as a possible mechanism to attenuate androgen responses in target tissues.

To see the rest of the Paper:

Click on the Link:

"Melatonin"
or Go To
https://pubmed.ncbi.nlm.nih.gov/12127045/
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Us Too Warriors,

Significant Association

After cross-checking the patients’ vitamin D levels with the severity of their COVID-19 symptoms and accounting for confounding factors, the researchers found that having a vitamin D level of above 30 ng/ml was significantly associated with having less severe COVID-19.

Among the 235 patients with confirmed COVID-19, only 32.8% had sufficient levels of the vitamin.

The researchers also found that the patients with sufficient vitamin D had higher blood lymphocyte counts and lower levels of C-reactive protein in their blood — both of which indicate a positive immune response.

The researchers speculate that this may have reduced the likelihood of developing cytokine storm, which can cause acute respiratory distress syndrome in COVID-19 patients, sometimes resulting in death.

The research, published in the journal PLOS ONE, could be valuable for doctors attempting to reduce the mortality rates of COVID-19 in the absence of an effective vaccine.

If further studies back up these findings, vitamin D supplements might offer a cost-effective way to limit the risk of severe COVID-19. It is important to note that this recent study has several limitations, which we address below.

To see the Paper:

Click on the Link:

"Significant Association"
or Go To
https://www.medicalnewstoday.com/articles/vitamin-d-sufficiency-may-reduce-complications-of-covid-19
*
Us Too Warriors,

Websites which may help with Cancer Treatment costs below.

To Go to The Websites:

Click on the Link:

Link 1 - Does Medicare cover cancer treatment? :
"Medicare"
or Go To
https://www.medicalnewstoday.com/articles/does-medicare-cover-cancer-treatment

Click on the Link:

Link 2 - What is Medicare buy-in? :
"Medicare buy-in"
or Go To
https://www.medicalnewstoday.com/articles/medicare-buy-in?utm_source=newsletter&utm_medium=email&utm_campaign=MNT%20Daily%20News&utm_content=2020-10-01&utm_country=&utm_hcp=&apid=27042543&utm_term=A

*
Us Too Warriors,

Discussion by email with Dr. Bilusic (NIH) about nitric Oxide for Prostate cancer

My email to Dr. Bilusic Follows:

Dr. Bilusic, If you are familiar with Nitric Oxides function in PCa I hope you will comment? I hope your research has made your path cross "How Nitric Oxide levels in the Blood affect prostate cancer growth". Mine path crossed it recently, when trying to protect my oldest brother from Covid-19. I sent him Nitric Oxide Booster (supplement used by muscle builders) because my online research suggested Nitric Oxide would prevent blood clots in the lung so oxygen levels and breathing would not be compromised. This was in June of this year at that time he had been off of ADT and Xtandi for 7 months (It was still working for at least 4 years before he stopped). When he stopped the fatigue and ability to walk were too hard to stand. After being off ADT and Xtandi for 7 months in June, his PSA went from 0.078 in Dec 2019 to 6.8 in June 2020 with a doubling time of less than 2 months. After being on Nitric Oxide Booster for one month his PSA dropped to 5.8 and now in another month it is 2.3. (And he is walking without a cane!)

My ( peter's) interpretation follows of NO action from my reading:
Nitric oxide is complicated- It has three forms of which I am not very familiar with as to how, why and under what circumstances they occur and which ones help or not. I have attached several papers but there are more. The most encouraging result was that in a phase two clinic among 29 men with recurrent PCa after radiation or surgery, 17 (62%) completed the 24 month trial with a heart Nitric Oxide medication. These 17 men had longer doubling times with average going from 13 months at start to 31 months at the end. I have not gotten the paper details yet. But I suspect that the men that did not stay on trial had PSA progression. There seems to be multiple Drugs/supplements/foods=beets & greens that can generate Nitric oxide and possibly many routes of action.
Cancers like We(Me & 2 Brothers) have with androgen sensitive growth seems to respond best to Nitric Oxide treatment. WE have a germline mutation =TMPRSS2-ERG fusion mutation. The mode of action that seems most to explain the beneficial results is: The indication is that Low Nitric Oxide promotes HIF-1 which is "Hypoxia inducing factor" which promotes angiogenesis = blood vessel growth to feed the cancer. But High levels of Nitric Oxide promote the Action of P53 which is the best anticancer molecule we have helping us. If a man has a P53 mutation so it does not function right then Nitric Oxide may not be helpful or as helpful ( But Stopping HIF-1 May still help to some extent?). Also, If a man's cancer is not responsive to androgen then Nitric Oxide treatment may not be as helpful.

Thanks for any comments, Best Peter

EMAIL REPLY from Dr. Bilusic follows:

Dr. Moon,

There is a lot of research going on about role of NO in prostate cancer. There are some contradictory studies. It is still considered experimental.

Best Marijo

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Us Too Warriors,

RVA Us Too - Low Testosterone and High DHT may be dangers in men for Covid damage/death but not ADT ???

Link 1.
I have read papers that show that reducing Dihydrotestosterone protects against Covid. Reducing DHT with Avodart increases testosterone. ADT also lowers DHT. Also see papers attached below

Link 2
COVID-19 May Deplete Testosterone For those who were asymptomatic, 65.2% reported a loss in libido.

I have attached Two Links below .

Best Peter
*
To Read The Papers:

Click on the Link:

Link 1 : "Therapeutic"
or Go To
https://www.healio.com/news/hematology-oncology/20200625/adt-and-covid19-a-therapeutic-discussion

Click on the Link:

Link 2 : "Testosterone"
or Go To
https://neurosciencenews.com/coronavirus-testosterone-17094/

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Us Too Warriors,

Nitric oxide and natural supplements effect on radiation damage

Link 1.
Radiation-induced gastrointestinal injury or radiation enteropathy is an imminent risk during radiation therapy of abdominal or pelvic tumors. Despite remarkable technological advancements in image-guided radiation delivery techniques, the risk of intestinal injury after radiotherapy for abdominal or pelvic cancers has not been completely eliminated. The irradiated intestine undergoes varying degrees of adverse structural and functional changes, which can result in transient or long-term complications. The risk of development of enteropathy depends on dose, fractionation, and quality of radiation. Moreover, the patients’ medical condition, age, inter-individual sensitivity to radiation and size of the treatment area are also risk factors of radiation enteropathy. Therefore, strategies are needed to prevent radiotherapy-induced undesirable alteration in the gastrointestinal tract. Many natural plant products, by virtue of their plethora of biological activities, alleviate the adverse effects of radiation-induced injury. The current review discusses potential roles and possible mechanisms of natural plant products in suppressing radiation enteropathy. Natural plant products have the potential to suppress intestinal radiation toxicity.

Link 2
Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction.

Link 3
Food Supplements to Mitigate Detrimental Effects of Pelvic Radiotherapy.

Link 4
Antibiotic Alleviates Radiation-Induced Intestinal Injury by Remodeling Microbiota, Reducing Inflammation, and Inhibiting Fibrosis

Link 5
Antibiotic Alleviates Radiation-Induced Intestinal Injury by Remodeling Microbiota, Reducing Inflammation, and Inhibiting Fibrosis

Link 6
Berberine Exerts a Protective Effect on Gut-Vascular Barrier via the Modulation of the Wnt/Beta-Catenin Signaling Pathway During Sepsis

Link 7
Total body irradiation-induced colon damage is prevented by nitrate-mediated suppression of oxidative stress and homeostasis of the gutmicrobiome. Nitric Oxide

I have attached Seven Links below .

Best Peter
*
To Read The Papers:

Click on the Link:

Link 1 : "Therapeutic Potential"
or Go To
https://www.tandfonline.com/doi/abs/10.1080/09553002.2018.1552374

Click on the Link:

Link 2 : "Baicalein"
or Go To
https://europepmc.org/article/med/31474856

Click on the Link:

Link 3 : "Food Supplements"
or Go To
https://www.siftdesk.org/index-article/Food-Supplements-to-Mitigate-Detrimental-Effects-of-Pelvic-Radiotherap/346639/58

Click on the Link:

Link 4 : "Antibiotic"
or Go To
https://pubmed.ncbi.nlm.nih.gov/32095719/

Click on the Link:

Link 5 : "Quercetin"
or Go To
http://rvaprostatecancersupport.org/PDF/9 29 20 Protective Effects of Quercetin on Intestinal Damage from radiation in rats.pdf

Click on the Link:

Link 6 : "Berberine"
or Go To
http://rvaprostatecancersupport.org/PDF/9 29 20 Berberine Exerts a Protective Effect on Gut mucosa from radiation.pdf

Click on the Link:

Link 7 : "Nitric Oxide"
or Go To
http://rvaprostatecancersupport.org/PDF/9 29 20 Nitric Oxide.pdf

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Us Too Warriors,

Androgen deprivation Therapy (ADT for PCa) and low testosterone may Increase chances of Kidney damage

My last brother diagnosed (Oct2019) with PCa has reduced Kidney Function and lower levels of testosterone so I thought I should see if there could be a connection between low testosterone and Kidney function.

The two papers attached below show there can be an increased problem with kidney function with low testosterone natural and by use of ADT. So if you have either of these conditions you need to check your Kidney function with CBC blood tests to see if it is affecting your kidneys by looking at your GFR levels and your Creatinine level.

Best Peter
*
To Read The Papers:

Click on the Links:

Link 1 : "Link 1"
or Go To
http://rvaprostatecancersupport.org/PDF/9 25 20 David-Testosterone Replacement Therapy (TRT) is Associated better Kidney function in Veterans.pdf *

To Read More Local Information:

Click on the Link:

Link 2 : "Link 2"
or Go To
http://rvaprostatecancersupport.org/PDF/9 25 20 joi130032.pdf
*********************************************
Us Too Warriors,

Lu177 treatment in men w/ Multiple treatments

PhaseI/IITrialoftheCombinationof177LutetiumProstatespecificMembraneAntigen617andIdronoxil(NOX66)inMenwithEnd-stageMetastaticCastration-resistantProstateCancer(LuPIN)
Best Peter

To Read More:

Click on the Link:

Link : "Lu177"
or Go To
http://rvaprostatecancersupport.org/PDF/09 22 20 PIIS2588931120300936.pdf
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Us Too Warriors,

Optimal chemohormonal sequencing for mCRPC MAY be Taxotere->Zytiga->Jevtana->Xtandi

(1) Taxotere (docetaxel) first

In a retrospective study presented at the Society for Urologic Oncology meeting, researchers at the Mayo Clinic reported on 112 patients with metastatic castration-resistant prostate cancer (mCRPC).

•Group A (80 men) had docetaxel (Taxotere) followed by one of the second-line hormonal therapies: either abiraterone (Zytiga) or enzalutamide (Xtandi)
•Group B (32 men) had a second-line hormonal therapy followed by Taxotere.
•Bone metastases were more common in Group B (87%) than Group A (58%)

Best Peter

To Read More:

Click on the Link:

Link: "Optimal Chemohormonal"
or Go To
https://www.prostatecancer.news/2019/12/optimal-chemohormonal-sequencing-for.html

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Us Too Warriors,

Testosterone to TREAT prostate cancer - are they crazy? No - it just may work. (mCRPC)

The attachment below shows that Bi Polar Testosterone can work to treat Hormone sensitive PCa not Just CRPC!!!
Best Peter

To Read More (Part 1 and Part 2):

Click on the Link:

Link : "Part 1"
or Go To
https://www.prostatecancer.news/2016/09/testosterone-to-treat-prostate-cancer.html

Link : "Part 2"
or Go To
https://www.prostatecancer.news/2016/09/testosterone-to-treat-prostate-cancer_5.html
*
Us Too Warriors,

Vitamin C May help with Muscle mass development in older men and women

I take about 6 grams = 6000 mg per day to fight PCa and now the paper below indicates it can help with my muscle mass
Best Peter

Lower Dietary and Circulating Vitamin C in Middle- and Older-Aged Men and Women Are Associated with Lower Estimated Skeletal Muscle Mass

To Read More:

Click on the Link:

Link : "Muscle Mass"
or Go To
http://rvaprostatecancersupport.org/PDF/09 8 20 Muscle mass.pdf
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Us Too Warriors,

High dose testosterone causes DNA damage and suppresses prostate cancer growth

I am very excited about this trial and my oldest Brother is in Seattle Wa. I do not know all the details yet, But I would like them to include Avodart to prevent high levels of Dihydrotestosterone which could drive Covid damage. OR use after we have a Vaccine for Covid.

Best Peter

To Read More:

Click on the Link:

Link: "Testosterone"
or Go To
https://cdmrp.army.mil/pcrp/research_highlights/20schweizer_highlight

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Us Too Warriors,

Androgen Receptor Blockers

PCa treatments which act as androgen receptor blockers like Xtandi reduces formation of TMPRSS2 proteins from provides access of Covid virus into lungs and testes cells that cause lung clots in cytokine storm and could make our younger sons not fertile if they get covid infected. AVodart and Proscar by blocking alpha reductase enzymes blocks Dihydrotestosterone and thus prevents formation of TMPRSS2. Attached below is a Clinical Trial study to see if Casodex Androgen Receptor Blocker in a clinical trial will fight COVID by blocking testosterone and lower TMPRSS2!!!!

If you do not have Lupron , or Xtandi or Avodart on board for your PCa treatment, I would recommend you get one of your doctors to prescribe Avodart as it is the easiest to get, low cost and minimum side effects to block TMPRSS2 to fight COVID. I have been taking it along with Proscar for 20 years as I have the TMPRSS2-erg Mutation.

The below Link is about A Randomized Clinical Trial Will Assess Efficacy and Safety of Bicalutamide in Hospitalized Patients With COVID-19

Best Peter

To Read More:

Click on the Link:

Link: "Bicalutamide"
or Go To
https://www.cancertherapyadvisor.com/home/cancer-topics/general-oncology/bicalutamide-covid19-coronavirus-randomized-clinical-trial-efficacy-treatment/

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Us Too Warriors,

Okra

When I was younger I did not like the texture of Okra, but I have acquired a taste for it and eat/enjoy it steamed. I have several plants in my garden (from seeds supplied from Rusty, one of our warriors - Thank You) and have been eating it a couple times a week recently.

The website below suggests it may fight several cancers, including PCa. (Okra May Fight Breast and Prostate Cancer)

Best Peter

To Read More:

Click on the Link:

Link: "Okra"
or Go To
http://www.edenprescription.com/Okra.html

*********************************************
Us Too Warriors,

For Your Information

A list of Useful items to fight Cancer.

Best Peter

Link 1. Unique targeting of androgen-dependent and -independent AR signaling in prostate cancer to overcome androgen resistance

Link 2. Dose-finding and Pharmacokinetic Study of DpC, Administered Orally to Patients With Advanced Solid Tumors

Link 3. A new anti-cancer drug for prostate cancer overcomes the twin problems plaguing researchers for decades. It halts metastasis (tumour spread) and drug resistance.

To Read More:

Click on the Link:

Link 1. : "Unique"
or Go To
http://rvaprostatecancersupport.org/PDF/08 31 20 PCa-DpC.pdf
*
Link 2 : "Pharmacokinetic Study"
or Go To
http://rvaprostatecancersupport.org/PDF/08 31 20 Clinical Trial.pdf
*
Link 3 : "Halts Metastasis"
or Go To
https://www.miragenews.com/new-anti-cancer-drug-breakthrough-for-prostate-cancer/

*********************************************
Us Too Warriors,

Abstract 3481

Another reason to get off the couch see below.

Abstract 3481: Continuous load bearing exercise inhibits the development of prostate cancer bone metastasis

Best Peter

To Read More:

Click on the Link:

Link: "Abstract 3481"
or Go To
https://cancerres.aacrjournals.org/content/80/16_Supplement/3481

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Us Too Warriors,

Radiation and Immunotherapy

Dr Drake is one of Jerry Deans Docs in NY,NY.

This paper makes interesting points of How Radiation and Immunotherapy may work together to make a local radiation treatment have a systemic effect.

Best Peter

To Read More:

Click on the Link:

Link: "Radiation and Immunotherapy"
or Go To
https://grandroundsinurology.com/radiation-immunotherapy-the-abscopal-effect/

*********************
Us Too Warriors,

Brown Seaweed

When my PSA started rising fast from 3.0 to 4.8 ng/ml in 3 months in 2016 I started using Fucoxanthin Supplement pills (3/dinner) taken in combination with Edamame frozen soybean steam for dinner. In the next three months my PSA dropped to 3.6 ng/ml from the 4.8. I lost track of this process; so In the next year my PSA climbed to 12.2ng/ml (5 month doubling time) before I found in Dec, 2017 the treatment that has put my cancer in remission.

But, I have rediscovered Fucoxanthin as a treatment for Covid-19 and also for cancer. The papers attached support this Fucoxanthin as a treatment for cancer and Covid 19.

I just purchased 12 bottles of Brown Seaweed as my source of Fucoxanthin from Swanson INC to keep my cancer away and help if I am exposed to Covid 19. Read the papers so you can protect yourself and family. Stay healthy

Best Peter

To Read More:

Click on the Link:

Link: "Brown Seaweed"
or Go To
http://rvaprostatecancersupport.org/PDF/08 18 20 PCa-Brown Seaweed-Fucoxanthin.pdf

Link: "Covid-19"
or Go To
https://thehill.com/opinion/healthcare/510852-can-seaweed-really-help-us-fight-covid-19

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Us Too Warriors,

Killing cancer cells

I have used Nsaids Over the counter at various times in my 26 year fight with cancer. I used Ibuprofen at higher doses for a year, and another time full dose aspirin. I stopped using them for many years because at these doses I think it was damaging my hearing but now I am taking one baby aspirin per day because I read it lowered ERG proteins which form part of my PCa Mutation =TMPRSS2-ERG fusion Gene. Killing cancer cells.

But, in addition, the following article suggests that baby aspirin improves PCa survival by fighting inflammation from the dying PCa cell debris and prevents it from feeding live cancer growth.

The dead cell debris is thought to contribute to the development of cancer treatment resistance as the dead cells help the cancer grow faster.

Best Peter

Dr. Sui Huang

Killing cancer cells is the fundamental objective of chemotherapy, radiation and targeted cancer therapies. However, these treatments often fail to eradicate tumors, and cancer often recurs.

So, is killing the problem?

Dr. Sui Huang (pictured above), professor and cancer biologist at Institute for Systems Biology, along with former mentee and longtime collaborator Dr. Dipak Panigrahy at Beth Isreal Deaconess Medical Center in Boston and colleagues at Harvard Medical School, show that dead cells, or cell debris, generated by treatments intended to eradicate tumor cells, actually act as strong stimulators of tumor progression. Their findings were published in The Journal of Experimental Medicine on November 30.

Traditional cancer therapies, then, become a double-edged sword: Too much and too fast, yet incomplete, killing of the tumor cell population will generate so much debris that the tumor stimulatory effect overpowers the decimation of tumor cells. The dead cells trigger a reaction that strengthens the cancer cells that have just escaped death by drugs: These become more like stem cells, which are resilient and robust, and eventually cause recurrence of the tumor.

To Read More:

Click on the Link:

Link: "Cancer Cells"
or Go To
http://rvaprostatecancersupport.org/PDF/08 14 20 Killing cancer cells.pdf

*******************************************************************
Us Too Warriors,

Attachments

I hope you find something useful in the Attachments. The first attachment describes a phase 3 trial designed which will open in the 4 th quarter which is for advanced cancer that has failed Xtandi or Zytiga with rising PSA. The second attachment has many other topics that may be helpful. All the Best

Best Peter

To Read More:

Click on the Link:

Link: "4 th Quarter"
or Go To
https://www.onclive.com/view/fda-provides-regulatory-clarity-on-phase-3-trial-design-for-veru-111-in-mcrpc

*

Link: "Other Topics"
or Go To
https://www.prostatepedia.net/blogs/prostatepedia

***
Us Too Warriors,

Immunology Is Where Intuition Goes to Die

There’s a joke about immunology, which Jessica Metcalf of Princeton recently told me. An immunologist and a cardiologist are kidnapped. The kidnappers threaten to shoot one of them, but promise to spare whoever has made the greater contribution to humanity. The cardiologist says, “Well, I’ve identified drugs that have saved the lives of millions of people.” Impressed, the kidnappers turn to the immunologist. “What have you done?” they ask. The immunologist says, “The thing is, the immune system is very complicated …” And the cardiologist says, “Just shoot me now.”

Best Peter

To Read More:

Click on the Link:

Link: "Immunology"
or Go To
https://www.theatlantic.com/health/archive/2020/08/covid-19-immunity-is-the-pandemics-central-mystery/614956/

*
Us Too Warriors,

Two Diseases For The Price of One Drug

I have now found several drugs and supplements that both fight prostate cancer and Covid virus. I have always liked having the benefit to two diseases for the price of one drug or supplement. I think this works because the drug/supplements improve the immune system which aids both conditions see below. Lactoferrin and Nitric OXide which I have recently found fights the Covid Virus but on checking - I find it also fights prostate and maybe other cancers. I have recently found that high dose vitamin D3, Vitamin C and Zinc that I have used to fight Prostate cancer also fights the effects of Covid virus. But also anti prostate cancer drugs that lower Di-hydrotesterone like Avodart or proscar lower TMPRSS2 protein formation which is the bad acting protein that allows the virus to enter our organ cells to damage/kill them.

As you might expect, I take advantage of all these drugs and supplements to fight my cancer and to prevent the virus. In fact, My brother for the last month started taking Nitric Oxide Booster when his PSA was doubling every two months or less after coming off of Xtandi because of the debilitating side effects so that his PSA had risen from.08 to 6.8 in about 10 months. The last PSA this week(after 6 weeks since the last) his PSA had dropped to 5.8 after being on Nitric Oxide booster for a month and was no longer doubling. YAAaaa!!!! When you are older your Nitric oxide drops to 5% of that of a 20 year old. Beets are a good source of NO.

See what these supplements can do to fight Covid and Cancers. Look for papers attached far below.
Best Peter

To Read More:

Click on the Link:

Link: "Lactoferrin"
or Go To
http://rvaprostatecancersupport.org/PDF/08 03 20 PCa-Lactoferrin selectivel Kill PC-3 PCa cells.pdf

*

Link: "Nitric Oxide"
or Go To
http://rvaprostatecancersupport.org/PDF/08 03 20 PCa-Nitric Oxide in Halting Cancer Progression.pdf

*************************************************
Us Too Warriors,

Is there an association between statin use and the risk of prostate cancer mortality?

See the attached paper. I just recently had my GP prescribe the Statin =Prarsstatin because my Cholesterol was at 200 and my apolipoprotein was very high both signs are not good for heart function. This was unusual and may be because of covid as I have not been able to play soccer or go to the YMCA.

Anyway many of the things that cause heart problems also grow cancer. The use of this statin turns out to be the best choice for slowing PCa deaths; see attachment.
Best Peter

To Read More:

Click on the Link:

Link: "Statin Use"
or Go To
https://medivizor.com/view_article/46047983

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Us Too Warriors,

Cryosurgical Tumor Cell Lysis and Intratumoral Immunotherapy

Regression of metastatic cancer and abscopal effects following in situ vaccination by cryosurgical tumor cell lysis and intratumoral immunotherapy: A case series

Abstract:

Purpose: To evaluate the efficacy and safety of a novel in situ cancer vaccination method for the treatment of aggressive solid tumors, with an initial focus on metastatic prostate cancer (PCa). Procedure: 27 consecutive patients with metastatic cancers (21 with PCa and 6 with other cancers), were treated by in situ cryosurgical lysis of tumor tissue followed by injection of ipilimumab, pembrolizumab or nivolumab, and sargramostim directly into the zone of lysis. This was followed by 30 daily s.c. injections of sargramostim. Patients received 1 to 3 cycles of the above therapy at intervals of ≥ 1 month. Responses to therapy were assessed by RECIST v.1.1 and for patients with PCa, serum PSA levels. This IRB-approved study, Shulman IRB Protocol #00027107, is a retrospective analysis (with prospective follow-up) of the practice of medicine of two physicians. All patients signed informed consent. Results: 21 patients with progressive metastatic PCa and 6 with other metastatic cancers (2 bladder, 1 pancreatic, 1 colon, 1 melanoma, and 1 unknown) were treated. RECIST responses for 2 patients (both with PCa) could not be evaluated due to a lack of follow-up imaging. Among the remaining 25 patients, CRs were seen in 9 (36%) patients and a PR in 1 (4%), for an ORR of 40%. SD was seen in 8 (32%) patients, and progression was seen in 7 (28%).
Best Peter

To Read More:

Click on the Link:

Link: "Immunotherapy "
or Go To
https://www.abstractsonline.com/pp8/#!/9045/presentation/7023

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Us Too Warriors,

Curcumin and Turmeric

Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine

Abstract:

The p53 tumor suppressor plays a major role in controlling the initiation and development of cancer by regulating cell cycle arrest, apoptosis, senescence, and DNA repair. The MDM2 oncogene is a major negative regulator of p53 that inhibits the activity of p53 and reduces its protein stability. MDM2, p53, and the p53-MDM2 pathway represent welldocumented targets for preventing and/or treating cancer. Natural products, especially those from medicinal and food plants, are a rich source for the discovery and development of novel therapeutic and preventive agents against human cancers. Many natural product-derived MDM2 inhibitors have shown potent efficacy against various human cancers. In contrast to synthetic small-molecule MDM2 inhibitors, the majority of which have been designed to inhibit MDM2- p53 binding and activate p53, many natural product inhibitors directly decrease MDM2 expression and/or MDM2 stability, exerting their anticancer activity in both p53-dependent and p53- independent manners. More recently, several natural products have been reported to target mutant p53 in cancer. Therefore, identification of natural products targeting MDM2, mutant p53, and the p53-MDM2 pathway can provide a promising strategy for the development of novel cancer chemopreventive and chemotherapeutic agents. In this review, we focus our discussion on the recent advances in the discovery and development of anticancer natural products that target the p53-MDM2 pathway, emphasizing several emerging issues, such as the efficacy, mechanism of action, and specificity of these natural products.
Best Peter

To Read More:

Click on the Link:

Link: "Curcumin and Turmeric"
or Go To
http://rvaprostatecancersupport.org/PDF/07 27 20 PCa-Natural products targeting the p53-MDM2 in PCa.pdf

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Us Too Warriors,

Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions

I would suggest you take many polyphenols pills to fight p53. I use many of them and they may be making my P53 more effective by increasing its positive P53 production to fight my cancer ? !!!!

Here is a list of the ones I take green tea, Dim, Quercetin, Fisetin, Berberine, Apigenin, curcumin, FoTi, Grape seed extract, pterostilbene, Wormwood, chaga mushroom, Turkey tail Mushroom, Boswella and more.
Best Peter

To Read More:

Click on the Link:

Link: "Targeting p53"
or Go To
https://www.sciencedirect.com/science/article/pii/S0734975019300667

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Us Too Warriors,

Apigenin: A Promising Molecule for Cancer Prevention

Abstract Apigenin, a naturally occurring plant flavone, abundantly present in common fruits and vegetables is recognized as a bioactive flavonoid shown to possess anti-inflammatory, antioxidant and anticancer properties. Epidemiologic studies suggest that a diet rich in flavones is related to a decreased risk of certain cancers, particularly cancers of the breast, digestive tract, skin, prostate and certain hematological malignancies. It has been suggested that apigenin may be protective in other diseases that are affected by oxidative process such as cardiovascular and neurological disorders, although more research needs to be conducted in this regard. Human clinical trials examining the effect of supplementation of apigenin on disease prevention have not been conducted although there is considerable potential for apigenin to be developed as a cancer chemopreventive agent.
Best Peter

To Read More:

Click on the Link:

Link: "Apigenin"
or Go To
http://rvaprostatecancersupport.org/PDF/07 19 20 PCa-Apigenin- A Promising Molecule for Cancer Prevention.pdf

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Us Too Warriors,

How Avodart for PCa and Vitamin D3 at doses of 5,000 to 8,000 IU can fight Covid as well as PCa

The paper below is helpful to understand How Avodart for PCa and Vitamin D3 at doses of 5,000 to 8,000 IU can fight Covid as well as PCa by reducing the production of DHT and C-reactive Protein specifically that both reduce TMPRSS2 proteins in the lungs, Gut and other body organs causing the inflammation of the cytokine storm.

Best Peter

To Read More:

Click on the Link:

Link: "Avodart"
or Go To
http://rvaprostatecancersupport.org/PDF/07 19 20 A-closer-look-at-TMPRSS2-This-could-help-treat-COVID-19.pdf

*************************
Us Too Warriors,

Vitamin D supplementation makes (lowers) my C-reactive protein very low = 0.57

My high Vitamin D supplementation makes (lowers) my C-reactive protein very low = 0.57; C - reactive Protein is considered low if =< 1.0.

My Vitamin D3 level is 100ng/ml which is considered the highest value that one should try to reach in your blood. The paper below shows the research backing up lowering of c-reactive protein to fight PCa. This Vitamin D3 supplementation lowers TMPRSS2 proteins which is related to my cancer mutation of TMPRSS2-ERG fusion which is one of the pieces of the puzzle that may have put my cancer in remission. About 50% of Prostate Cancer patients have this mutation

Best Peter

To Read More:

Click on the Link:

Link: "C-reactive Protein"
or Go To
http://rvaprostatecancersupport.org/PDF/07 19 20 PCa-C-reactive protein in prostate Growth AsianJAndrol163467-2256248_003736.pdf

*
Us Too Warriors,

Bowel Problems

Some parameters which may affect PCa occurrence rate are discussed in the attachments. I am aware of a number of our men have bowel problems, Generally any inflammation is a problem for any one with cancer.

Association between inflammatory bowel disease and prostate cancer: A large‐scale, prospective, population‐based study

and

Hematologic Markers and Prostate Cancer Risk: A Prospective Analysis in UK Biobank.
Best Peter

To Read More:

Click on the Link:

Link: "Inflammatory Bowel Disease"
or Go To
https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.33048

and

To Read More:

Click on the Link:

Link: "Hematologic Markers"
or Go To
https://cebp.aacrjournals.org/content/early/2020/06/22/1055-9965.EPI-19-1525

*
Us Too Warriors,

Dr. Meyers Prescription

I thought you might want to revisit Dr. Meyers prescription to see if it has anything to help you control your cancer. it is Attached below:

Best Peter

To Read More:

Click on the Link:

Link: "Dr. Meyers Prescription"
or Go To
https://grandroundsinurology.com/durable-complete-remission-prostate-cancer/

Hot Sheet

US Too Warriors:
Sign up to get the Hot Sheet newsletters. July 2020 Hot Sheet :

Link: July 2020
or Go To
https://www.ustoo.org/PDFs/HotSheets/UsTOO_HotSHEET_July_2020.pdf

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Us Too Warriors,

Nitric Oxide

The Nitric oxide (NO) Molecule In Our Body Has Many Good Effects. I Am Going To State A Few Researched Effects But Unfortunately It Fall As We Age-It May Be Why Younger People Are Less Likely To Be Damaged Or Die From Covid.

Info for
1. NO is good for the heart
2. It helps Build Muscles and now there are muscle building supplements with NO.
3. You get more in your body by breathing in through the nose as it is released from nasal passages and by humming between breaths. and breathing out through the mouth- this is not easy to do without thinking about it
4. It helps oxygen blood saturation if small Amounts of NO are added to oxygen Breathed in for Covid therapy in the hospital
5. Dark Chocolate (w low sugar) and Beets are the source of NO.
6. You can Check your NO in your saliva by using a test strep from BERKELEYLIFE.COM -I WAS BETWEEN DEPLETED AND LOW WHEN I FIRST MEASURED MY NO SALIVA LEVEL THREE WEEKS AGO. NOW AFTER EATING PICKLED BEETS & LOW SUGAR DARK CHOCOLATE & TAKING A TAKING NITRIC OXIDE BOOSTER SUPPLEMENT I HAVE RAISED MY SALIVA NO TO BETWEEN THE "TARGETED TO HIGH LEVEL"

FROM SNAP ==>https://www.amazon.com/s?k=snap+nitric+oxide&hvadid=78409029

Info Prostate cancer
1. High levels of NO in blood are good for slowing this cancer growth and preventing CRPC.
2. See Paper attached FURTHER below THE EMPTY BLOCK BELOW:
BEST PETER Best Peter

To Read More:

Click on the Link:

Link: "Nitric Oxide"
or Go To
http://rvaprostatecancersupport.org/PDF/07 01 20 Yang And Ying Of NO in PCA.pdf

**********************
Us Too Warriors,

Bicalutamide: first lab results, nadir comes when?

I am using 150 mg casodex with metformin 1500mg & Avodart and proscar plus doxycycline and femara that blocks estrogen, hot flashes & breast pain. The Blog copied below describes the use in men with PCA and comments by other PCA men.

To Read More - Click on the Link:

Link: Blocks
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/143677191/bicalutamide-first-lab-results-nadir-comes-when

Us Too Warriors,

Prostatepedia - Effective June 15, Prostatepedia will become a free publication of the National Alliance of State Prostate Cancer Coalitions (NASPCC).

Attached below is the newsletter and you will be able to get it free in the future. I have been paying $86 per year to send it out to you over the years but now you can sign-up to get it for free as Dr. Meyers is changing the way it is available.
Best Peter

To Read More:

Click on the Link:

Link: "Prostatepedia"
or Go To
http://rvaprostatecancersupport.org/PDF/06 13 20 Prostatepedia_V5N8_9_AprilMay2020.01.pdf

Us Too Warriors,

Blocking the PD-1/PD-L1 Axis in Advanced Prostate Cancer: Are We Moving in the Right Direction?

I received an email from Fred Johnson, one of our members, about the use of this immunotherapy for treatment of pancreatic cancer successfully for Harry Reid (former leader of the Senate) in a passionate USE in small group 4 patients. It also has some small benefit in PCa if the cancer is advanced (Mutations & Mets) and it will be important to Identify the men it will help with the right mutations.
Best Peter

To Read More:

Click on the Link:

Link: "Moving"
or Go To
https://pubmed.ncbi.nlm.nih.gov/31032288/

Us Too Warriors,

SEE the website below for agents you may want to investigate with your Doctor. If you have an unusual doctor who uses drugs off label you may find he will prescribe other drugs off label. I have 7 off label drugs and only one FDA approved, Casodex.. one of my off label drugs metformin acts on the mTor which is one of the pathways that grows Pten mutated PCa. Rapamycin (another drug for the mtor pathway) is FDA approved for kidney cancer but one of our members had good results with this for his mTor pathway for his mets now going on 12 years from a John Hopkins Clinic trial but it was not good enough for other men on the trial to get it FDA approved . But if you went to an oncologist who treats kidney cancer and PCa you may be able to get access to rapamycin for your PCa. It would be good to know if mTor is an active pathway for your PCa (Pten mutated). Always check the side effects of any drug you try.
Best Peter

To Read More:

Click on the Link:

Link: "Drugs"
or Go To
http://rvaprostatecancersupport.org/PDF/06 11 20 PCa-PtenTherapeutic targeting of cancers with loss of PTEN function.pdf

Us Too Warriors,

I think Jerry Deans is going to add Fisetin to his Armour against PCa. I have attached the below paper for your consideration for adding it to your own Armour. It Blocks most of the cancer growth, invasion and metastasis pathways.

It is right up there with Curcumin and green tea in its actions.
Best Peter

To Read More:

Click on the Link:

Link: Fisetin
or Go To
http://rvaprostatecancersupport.org/PDF/06 03 20 PCa-Fisetin AMOUR for PCa biomolecules-09-00174.pdf

Us Too Warriors,

RVA Us Too Warriors and family. The Nitric oxide (NO) molecule in our body has many helpful facets. I am going to state a few researched effects but there is much more to know. Also - Info for CoViD-19

Nitric oxide (NO) is a ubiquitous signaling molecule in the human body with well-known roles in many different processes and organ systems.

1. Nitric oxide (NO) is good for the heart
2. It helps Build Muscles and now there are muscle building supplements with Nitric oxide (NO).
3. You get more in your body by breathing in thru the nose as it is released from nasal passages and by humming between breaths.
4. It helps oxygen blood saturation if small Amounts of Nitric oxide (NO) are added to oxygen Breathed in for Covid therapy
5. Dark Chocolate (with low sugar) and Beets are a source of NO.

Info Prostate cancer

1. High levels of NO in blood are good for slowing this cancer growth and preventing CRPC.
2. See Paper attached below

Best Peter

To Read More:

Click on the Link:

Link: Nitric oxide
or Go To
http://rvaprostatecancersupport.org/PDF/05 29 20 Yang And Ying Of NO in PCA.pdf

You can buy strips on line to test your saliva first thing in the morning by put a drop on the strip (not put in mouth) to see if your diet need to be enhanced with more greens, beets and Dark low sugar chocolate etc. I tried to find them at Walgreens and CVS locally with no Luck. Search on line for "nitric Oxide Test strips" if you want to find them. By age fifty Nitric Oxide in the body has dropped 50% from the 20's. I do not know what it is at 80 but I will find out. And to eat the right foods See the below Link:

Click on the Link:

Link: Foods
or Go To
https://swfas.org/foods-boost-nitric-oxide-levels-naturally/

Us Too Warriors,

Please find analysis by Dr, Moyad from Us Too International on possible treatments to mitigate Covid -19 Virus in the nose and some on going analysis of possible on going clinical trial treatments with nasal spray (etc) to reduce Virial load and contamination with salt nasal sprays etc. This is unproven but may prove useful. Dr. Moyad has not been my favorite for analysis of supplements that aid in PCa treatment as he tends to have negative attitude and often recommends too little or says things do not work in studies that used too little to be effective but in this case I think he has put a lot of thought into these investigations on studying Covid -19. I hope you find it useful.
Best Peter

To Read More:

Click on the Link:

Link: Covid-19
or Go To
http://rvaprostatecancersupport.org/PDF/05 28 20 Conquering COVID Part 2.pdf

Us Too Warriors,

The paper below suggests metformin often used by diabetics to reduce blood sugar can slow PCa. High Sugar levels grow cancer.
Best Peter

To Read More:

Click on the Link:

Link: Metformin
or Go To
http://rvaprostatecancersupport.org/PDF/05 28 20 PCa-Metformin in Chemotherapy-naive Castration-resistant Prostate.pdf

*
Us Too Warriors,

I have been using Fisetin from Swanson to put my PCa in remission. I have mention this in the past at meetings but the paper I requested from the Author several months ago below has just Arrived! It is below for your information. Casodex is the Anti-androgen I am using now for 2 1/2 years to trigger my cancer remission.
Best Peter

To Read More:

Click on the Link:

Link: Fisetin
or Go To
http://rvaprostatecancersupport.org/PDF/05 17 20 PCa-Fisetin.pdf

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Us Too Warriors,

Natural Product MDM2 Inhibitors: Anticancer Activity and Mechanisms of Action - See Below
Best Peter

To Read More:

Click on the Link:

Link: Inhibitors
or Go To
http://rvaprostatecancersupport.org/PDF/05 15 20 PCa-Natural Product MDM2 Inhibitors.pdf

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Us Too Warriors,

When I first learned of my Metastasis 2 1/2 years ago I asked my doctor about getting Xofigo, a nuclear injection that goes to bone and radiates the bone marrow cancer in situ. He told me it is only recommended if there is bone pain which fortunately I did not have. The study below indicates that marrow damage can be as high 45% in PCa patients, especially those that have already been treated by external radiation. See below
Best Peter

To Read More see the Two Links:

Click on the Link:

Link: Xofigo
or Go To
https://www.ncbi.nlm.nih.gov/pubmed/32140364

Link: Bone Marrow Failure
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757096/

*
Us Too Warriors,

Kill 2 Birds with one Stone.

Wormwood for PCa and it may be good to fight Covid 19
Best Peter

To Read More

Click on the Link:

Link: Covid 19
or Go To
http://rvaprostatecancersupport.org/PDF/05 4 20 COVID19 - Artemisia+annua+against+viruses Swanson =Wormwood.pdf

Link: Cancer
or Go To
http://student-doctor.dryarnell.com/2013/01/29/artemisinin-and-prostate-cancer/

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Us Too Warriors,

This information below was published in Richmond paper which may you have seen. i believe I sent information about the use of Vitamin C for virus which i take 3000 mg per day along with high dose Vitamin D ( >10,000 IU) and Zinc (40 mg) but Infusion of Vitamin C ~ 15 grams at a time by IV is much better. I have been in contact DR Fowler at VCU who says that this infusion should help in the COVID 19 fight.

Remind me ... what is the role of Vit C in PCa?

Aha... nice to see my perception from weeks ago reflected finally even in conservative Richmond Times Dispatch! (Re: Cytokine Storm)

"There’s a growing belief in the medical community that it isn’t the coronavirus itself that kills a patient, but the patient’s extreme inflammatory response. The immune system floods the cells with proteins called cytokines. When the body produces a rush of cytokines — known as a cytokine storm — blood vessels become weak, allowing fluid to leak in and fill the lung cavities. This can shut down organs and make recovery difficult.
Best Peter

To Read The Richmond Times-Dispatch Article:
A Richmond doctor’s dramatic story of COVID-19 infection, hospitalization and survival.
Click on the Link:

Link: Article
or Go To
https://www.richmond.com/special-report/coronavirus/a-richmond-doctor-s-dramatic-story-of-covid-19-infection-hospitalization-and-survival/article_750722ad-7918-544d-bc4d-798d456033f6.html

Us Too Warriors,

Coronavirus-19 - Prostatepedia - March 2020 - Volume 5 - No. 6 Best Peter

These are indeed trying times. As we grapple to control the COVID-19 pandemic, you as prostate cancer patients may in particular be worried about both your risk of contracting COVID-19 or of how the pandemic will compromise your prostate cancer treatment plan.

To Read the Article - Click on the Link:

Link: Prostatepedia
or Go To
http://rvaprostatecancersupport.org/PDF/04 06 20 Prostatepedia_V5N7_March2020.pdf

Us Too Warriors,

All, This looks promising for advanced PCa.
Best Peter

Prostate-specific membrane antigen (PSMA)-targeting Radio-Ligand Therapy with beta-emitting 177Lutetium has already been investigated in several early phase dosimetry studies, demonstrated promising results in phase-2, and recently the first phase-3 trial finished recruitment. In contrast, PSMA-targeting alpha-particle therapy (TAT) has only been evaluated in few preclinical experiments, preliminary dosimetry attempts and some retrospective observational studies, yet. First clinical experience with 225Ac-PSMA-617 demonstrates promising antitumor activity with a 63%-70% PSA>50%-response rate, 10-15 months duration of response and complete remissions in approximately ten percent of patients, some of them with enduring relapse-free survival.

For More Information - Click on the Link:

Link: Radio-Ligand Therapy
or Go To
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/120144-225ac-psma-617-for-therapy-of-prostate-cancer.html

Us Too Warriors,

Below are information Changes that may occur as the Pandemic gets worse.
Best Peter

COVID-19 Pandemic Rearranges Oncology Practice, Policies at Seattle Cancer Care Alliance
Danielle Ternyila - Published Online:1:00 PM, Fri March 20, 2020

As the Coronavirus disease 2019 (COVID-19) pandemic evolves, healthcare providers in the oncology realm are faced with a number of unforeseen challenges requiring immediate attention and swift changes in policies. Experts at the Seattle Cancer Care Alliance (SCCA) shared their insights and advice with the public in a recent article to demonstrate how they have adapted to provide the most optimal care for patients with cancer in light of the COVID-19 outbreak.

For More Information - Click on the Link:

Link: Oncology Practice
or Go To
https://www.targetedonc.com/news/covid19-pandemic-rearranges-oncology-practice-policies-at-seattle-cancer-care-alliance?p=1

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Prostatepedia Jan/Feb 2020

Immunotherapy for prostate cancer.

To Read the Article - Click on the Link:

Link: Prostatepedia
or Go To
http://rvaprostatecancersupport.org/PDF/03 13 20 Prostatepedia_Jan_Feb2020_V5INo5_6.pdf

***********************************************

COV-19 Virus

RVA - Us Too Warriors:

(COV-19 Virus)

Please see the LEF recommendations for the COV -19 Virus. I take all of the supplements and Metformin prescription routinely for my cancer except Cimetidine so they are doing double duty on COV-19.

Check out this website for agents to help reduce the problem. A word to the wise, the use of Cimetidine ( in Tagamet) should be restricted to the early stages of just a cough of the Virus as it may make the cytokine storm worse if used when fever occurs

To Read More - Click on the Links:

Link: Life Extension
or Go To
https://www.lifeextension.com/protocols/infections/2019-novel-coronavirus-sars-cov2-covid-19?sourcecode=INC210E&utm_medium=email&utm_source=misc&utm_campaign=coronavirus-INC210E-0310&utm_content=article2-readmore&M_BT=49905301

Link: Influenza
or Go To
https://www.lifeextension.com/protocols/infections/influenza

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New Principle for Eradicating Cancer: Leave No Dead Cells Behind

Killing cancer cells is the fundamental objective of chemotherapy, radiation and targeted cancer therapies. However, these treatments often fail to eradicate tumors, and cancer often recurs.

So, is killing the problem?

Dr. Dipak Panigrahy at Beth Isreal Deaconess Medical Center in Boston and colleagues at Harvard Medical School, show that dead cells, or cell debris, generated by treatments intended to eradicate tumor cells, actually act as strong stimulators of tumor progression. Their findings were published in The Journal of Experimental Medicine on November 30.

To Read the Article - Click on the Link:

Link: Leave No Dead Cells Behind
or Go To
http://rvaprostatecancersupport.org/PDF/03 06 20 New Principle for Eradicating Cancer.pdf

*******

Fatigue

RVA - Us Too Warriors:

Fatigue is a common symptom

Fatigue is a common symptom from cancer treatments especially advanced cancers and if on ADT Lupron and some antiandrogens like Xtandi.

Consumer Labs which analyzes supplements for purity and reliability of the dose content also discusses their use to help reduce fatigue. (See below)

To Read the Article - Click on the Link:

Link: Fatigue
or Go To
http://rvaprostatecancersupport.org/PDF/3 4 20 Supplements to Increase Energy.pdf

***************************************************************************************************

Cell Damage/Inflammation Damage

RVA - Us Too Warriors:

Lactate Dehydrogenase

Lactate Dehydrogenase in the blood is a sign of cell damage/inflammation damage which is released into the blood and can occur from the damage/inflammation from cancer.

One thing to be aware of is do not do heavy workouts near the days of the blood test as the muscle cell injury will release LDH into the blood. Also avoid lactate added to food - I have seen it as additive to baked goods - do not buy them. Vitamin C supplements may lower LDH,

If LDH values are dropping with Chemo treatment it may be a sign it is working!!!

See paper below Best Peter

To Read the Article - Click on the Link:

Link: Cell Damage/Inflammation Damage
or Go To
http://rvaprostatecancersupport.org/PDF/3 2 20 1-s2.0-S1558767319302253-main.pdf

***

Celastrol, an active constituent of the TCM plant Tripterygium
wilfordii Hook.f., inhibits prostate cancer bone metastasis

Background:
Treatment failure of prostate cancer (PCa) is often due to bone metastasis. Celastrol, an active constituent of Tripterygium wilfordii roots, has shown anti-tumor effects in previous studies in accordance with its indication in traditional Chinese medicine.

To Read more on this Subject
Click on the Link:

Link: Celastrol
or Go To
https://www.nature.com/articles/pcan201661

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Anti-androgens may increase mortality risk in men with CVD
Badar M. Mian, MD
August 30, 2019 - Volume: 47 - Issue: 9

Genitourinary Cancers, Prostate Cancer

Badar M. Mian, MDAdvanced prostate cancer and cardiovascular disease often coexist in older men. Over the last 5 years, new second-generation antiandrogens, namely abiraterone (ZYTIGA) and enzalutamide (XTANDI), are being used with more frequency in men with advanced prostate cancer. Patients with significant cardiovascular disease (CVD) are often excluded from clinical trials for reasons that are understandable. But in clinical practice, the excluded patients are often the ones treated with those same medications.

A new study suggests that newer antiandrogens may increase the risk of early mortality and hospitalization, especially in men with known CVD such as myocardial infarction, atrial fibrillation, congestive heart failure, stroke, or ischemic heart disease (Eur Urol Aug. 2, 2019 [Epub ahead of print]).

Lu-Yao and colleagues used the Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked files (representing nearly 31% of the U.S. population) to identify men with prostate cancer who had received chemotherapy and abiraterone or enzalutamide. A total of 3,876 patients were eligible for the study, including 2,845 treated with abiraterone and 1,031 treated with enzalutamide. The main goal of the analysis was to determine the mortality rate within 6 months after starting therapy with these two antiandrogens. They also wished to determine the risk of hospitalization after the initiation of antiandrogen therapy.

Also from Dr. Mian: Untreated MIBC has short natural course, significant morbidity

Interestingly, 67% of the eligible patients had one or more documented CVD before receiving abiraterone or enzalutamide.

In the post-chemotherapy group of patients being treated with abiraterone, 24% died within 6 months, compared with 17% in the pivotal trial that led to its approval. Among patients being treated with enzalutamide, 28% died within 6 months, compared with 12% in the pivotal trial. In the group without chemotherapy, 18% of patients died within 6 months of starting abiraterone and 17% died within 6 months of starting enzalutamide.

In the post-chemotherapy cohort receiving either abiraterone or enzalutamide, there was no significant difference in hospitalization rates between the two drugs. However, those with one or two CVDs had a 43% increased risk of hospitalization compared to those with no CVDs.

***************
Next: Higher hospitalization rate in abi patients with no chemo

Antiandrogens may increase mortality risk in men with CVD: Page 2 of 2
Badar M. Mian, MD

August 30, 2019 - Volume: 47 - Issue: 9

Genitourinary Cancers, Prostate Cancer

Higher hospitalization rate in abi patients with no chemo

In the group without chemotherapy, abiraterone was associated with a higher rate of hospitalization than enzalutamide among patients with one or more CVDs. In this group, hospitalization rate was higher with abiraterone use even in the patients with no history of CVD.

As stated by the authors, the worse outcomes (cardiovascular toxicity and/or mortality) following the use of abiraterone have been reported by previously published meta-analyses. In the STAMPEDE trial, the addition of abiraterone was associated with improved cancer-free-survival but no real improvement in overall survival, likely due to increased cardiovascular mortality.

It appears that abiraterone is associated with worse outcomes even if there is no documented chemotherapy or CVDs. However, without direct comparison, we cannot suggest that one drug is superior to the other. Other antiandrogens such as apalutamide (Erleada) and darolutamide (Nubeqa) have been approved recently and the use of antiandrogens has been moving “upfront;” eg, before chemotherapy and without metastases. This will likely result in increased use of drugs in this class, making the issue of adverse outcomes even more relevant.

Read: Renal mass biopsy safe, but when is it necessary?

The usual limitations of a retrospective analysis apply to this study as well. The data do not allow for a comparison with an appropriate control group that did not receive abiraterone or enzalutamide, or direct comparison. However, the Medicare-linked SEER data represent a broad cross-section of the population that is afflicted with prostate cancer and CVDs, which makes the information presented here quite pertinent for most clinicians.

The phenomenon of worse outcomes in the real-world setting after the initial approval of a drug or device has been well documented. Clinicians often loosen the criteria beyond what was allowed in the clinical trials, exposing the patients to a host of drug-drug or drug-disease interactions.

The subjects of this study had also received androgen deprivation therapy, which is associated with developing CVDs. Is it possible that these subjects were primed, through previous use of ADT, for worse outcomes following the addition of abiraterone and enzalutamide? The unique contribution of these second-generation antiandrogens to cardiovascular mortality is not entirely clear.

Several professional organizations are offering workshops geared towards incorporating these and other oral anti-cancer agents into the practice of urology. Hopefully, the educational activities will sufficiently emphasize a more careful selection of patients for these drugs. There is a clear impetus for a multidisciplinary program to monitor the treatment and adverse outcomes of newer antiandrogens which, at present, may be out of the comfort zone of many urologists.
***
Overview of Treatment for Advanced Prostate Cancer, including Metastatic Disease – Novel Treatment – Summary:

RVA - Us Too Warriors:

Abstract:
The genetic landscape of prostate cancer has been well-mapped in recent years, and the discovery of the vast array of mutations that can occur in mCRPC has led many researchers to try and determine if any are actionable. Novel therapies currently in development include androgen receptor inhibitors, epigenetic modulators, cyclin-dependent kinase (CDK) 4/6 inhibitors, and various immunotherapies, but researchers looking at PI3Kinase/Akt inhibition, PARP inhibitors, and Lu-PSMA have presented the most promising data so far.

To Read more on this Subject
Click on the Link:

Link: Novel Therapies
or Go To
https://grandroundsinurology.com/overview-of-treatment-for-advanced-prostate-cancer-including-metastatic-disease-novel-treatment/?utm_campaign=Weekly%20Email%20GRU&utm_source=hs_email&utm_medium=email&utm_content=83375949&_hsenc=p2ANqtz--HeuHAk88-eSaWcZLrTYO7RFwgQyKTXu2YPf9W0IOjar38r52gxIPmBYHVshAjww9GQqtoIawLsgsQFqs42_YzLRzxjw&_hsmi=83375949

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Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents

RVA - Us Too Warriors:

I hope you can find your way through the maze to find the plants that fight your cancer.

Abstract
Prostate cancer is a heterogeneous disease, the second deadliest malignancy in men and the most commonly diagnosed cancer among men. Traditional plants have been applied to handle various diseases and to develop new drugs. Medicinal plants are potential sources of natural bioactive compounds that include alkaloids, phenolic compounds, terpenes, and steroids. Many of these naturally-occurring bioactive constituents possess promising chemopreventive properties. In this sense, the aim of the present review is to provide a detailed overview of the role of plant-derived phytochemicals in prostate cancers, including the contribution of plant extracts and its corresponding isolated compounds.

To Read the Article - Click on the Link:

Link: Phytochemicals
or Go To
http://rvaprostatecancersupport.org/PDF/2 10 20 PCa-Flavanoids from numerous Plants to fight PCa.pdf

*****

ASCO 2019: ENZAMET, Overall Survival Results
of a Phase III Randomized Trial of Standard-of-care Therapy with or
without Enzalutamide for mHSPC, an ANZUP-led International Cooperative Group Trial

RVA - Us Too Warriors:
The 70 to 80% loss of QOL in both groups as shown by graphs at the end of this abstract is shocking to me. It is the reason I have avoided ADT like the plague. I am finding I am increasing my work out weights slowly at YMCA and at home. My Antioxidant and anti-inflammatories are designed to slow my aging as well as slow my cancer. I hope you can find your own happy life style to follow.

Barcelona, Spain (UroToday.com) At 2019 ASCO meeting, Davis and colleagues previously reported that treatment with enzalutamide rather than an older non-steroidal anti-androgen (bicalutamide, nilutamide, or flutamide), resulted in longer overall survival when added to standard first-line treatment, with or without concurrent early docetaxel, in mHSPC (HR 0.67, 95% CI 0.52 to 0.86, p = 0.002).1 Additionally, enzalutamide also leads to longer progression free survival (HR 0.40, 95% CI 0.33-0.49). At the ESMO 2019 prostate cancer session, Dr. Stockler and colleagues from the ENZAMET consortium reported results of the health-related quality of life data.

To Read the Article - Click on the Link:

Link: Enzamet
or Go To
https://www.urotoday.com/conference-highlights/asco-2019-annual-meeting/asco-2019-prostate-cancer/112971-asco-2019-overall-survival-results-of-a-phase-iii-randomized-trial-of-standard-of-care-therapy-with-or-without-enzalutamide-for-mhspc-enzamet-an-anzup-led-international-cooperative-group-trial.html

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Systemic Alkalinisation Delays Prostate Cancer Cell Progression in TRAMP mice

RVA - Us Too Warriors:

IS Alkaline water Good for Bone density, Preventing dental decay, dry mouth from chemo therapy, and slowing Prostate cancer???.

Abstract
The microenvironment of solid tumours is extremely acidic and this condition arises since the precancerous stage. This acidic milieu could therefore provide a useful target for both prophylactic and therapeutic approaches. In TRAMP transgenic mice, an in vivo model of prostate adenocarcinoma (AC), oral administration of alkaline water was devoid of unwanted side effects, and when started from an early age was as effective as NaHCO3 in significantly delaying tumour progression, while when started when prostate tumours were already present, a nonstatistically significant trend in the same direction was detected. These findings indicate that the use of alkalinizing drugs should be considered for chemoprevention and, in association with standard chemotherapy, for treatment of human prostate AC.

To Read the Article - Click on the Link:

Link: Alkalinisation
or Go To
http://rvaprostatecancersupport.org/PDF/2 9 20 Astigiano-2017-Systemic-alkalinisation-delays-pros.pdf

***************************************************************************************************

Quercetin Targets hnRNPA1 to Overcome Enzalutamide Resistance in Prostate Cancer Cells

RVA - Us Too Warriors:

I read that this may keep Taxane from failing too. Dose recommended of quercetin is 1000 to 3000 mg /day.

Abstract
Prostate cancer remains dependent on androgen receptor signaling even after castration. Aberrant androgen receptor signaling in castration-resistant prostate cancer is mediated by mechanisms such as alterations in the androgen receptor and activation of interacting signaling pathways. Clinical evidence confirms that resistance to the next-generation antiandrogen, enzalutamide, may be mediated to a large extent by alternative splicing of the androgen receptor to generate constitutively active splice variants such as AR-V7. The splice variants AR-V7 and ARv567es have been implicated in the resistance to not only enzalutamide, but also to abiraterone and other conventional therapeutics such as taxanes. Numerous studies, including ours, suggest that splicing factors such as hnRNPA1 promote the generation of AR-V7, thus contributing to enzalutamide resistance in prostate cancer cells. In the present study, we discovered that quercetin, a naturally occurring polyphenolic compound, reduces the expression of hnRNPA1, and consequently, that of AR-V7. The suppression of AR-V7 by quercetin resensitizes enzalutamide-resistant prostate cancer cells to treatment with enzalutamide. Our results indicate that quercetin downregulates hnRNPA1 expression, downregulates the expression of AR-V7, antagonizes androgen receptor signaling, and resensitizes enzalutamide-resistant prostate cancer cells to enzalutamide treatment in vivo in mouse xenografts. These findings demonstrate that suppressing the alternative splicing of the androgen receptor may have important implications in overcoming the resistance to next-generation antiandrogen therapy. Mol Cancer Ther; 16(12); 2770–9. ©2017 AACR.
Best Peter

To Read the Article - Click on the Link:

Link: Quercetin
or Go To
https://mct.aacrjournals.org/content/16/12/2770

*****

Luteolin

RVA - Us Too Warriors:

Luteolin inhibits blood vessel growth to slow PCa. See attachment below Below.

Best Peter

To Read the Article - Click on the Link:

Link: Luteolin
or Go To
http://rvaprostatecancersupport.org/PDF/2 1 20 PCa-Luteolin.pdf

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PSA Doubling Time and Absolute PSA Predict Metastasis-free Survival

RVA - Us Too Warriors:

PSA Doubling Time and Absolute PSA Predict Metastasis-free Survival in Men With Biochemically Recurrent Prostate Cancer after Radical Prostatectomy - Beyond the Abstract
My cancer metastasized between my 16th and 19th years after BCR. During that time My PSA went from 2.2 to 12 and PSA doubling time went from 18 months at the 16th year to 5 months in the 19th year. I wish I had started my present casodex/metformin/avodart(dutasteride)/doxycycline treatment when my PSA started to double faster after it went over 1.3 which had a doubling time of 3 to 4 years. I start the caosodex/etc treatment as soon as the Axumin pet scan showed multiple lymph nodes in my pelvis and in my right hip socket femur. Two MRI scans during this 3 year fast rise in PSA did not show any mets because MRI is not good at seeing lymph node mets and MRI did not extend down to my hip - I did not know these limitations when had 2 MRIs as my PSA increased faster. I did have the MRI extended to cover my hip and the hip bone met showed up.

If possible you should add treatments to stop mets if your PSA is rising fast (a short doubling time the abstract below indicates that a doubling time of less than 7.5 months for is point at which mets will occur. I would suggest 9 months to give you time to get the treatment started. Read the following abstract to get more information. I am fortunate that my METs have respond for two years now with PSA < 0.025 - I do not know if I have no mets now because I can not image them as the PSA is to low to detect

Best Peter

To Read the Article - Click on the Link:

Link: PSA Doubling Time
or Go To
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/118729-psa-doubling-time-and-absolute-psa-predict-metastasis-free-survival-in-men-with-biochemically-recurrent-prostate-cancer-after-radical-prostatectomy-beyond-the-abstract.html

***************************************************

The Aberrant Hedgehog (Hh) Signaling Induced by Mutations

RVA - Us Too Warriors:

This growth SHH pathway is slowed down by such supplements as Vitamin D3, Green tea, Curcumin, Berberine, Apigenin, resveratrol, quercetin. All of which I have been using - some for many years. Swanson is a Good source.

The aberrant Hedgehog (Hh) signaling induced by mutations or overexpression of the signaling mediators has been implicated in cancer, associated with processes including inflammation, tumor cell growth, invasion, and metastasis, as well as cancer stemness. Small molecules targeting the regulatory components of the Hh signaling pathway, especially Smoothened (Smo), have been developed for the treatment of cancer. However, acquired resistance to a Smo inhibitor vismodegib observed in clinical trials suggests that other Hh signaling components need to be explored as potential anticancer targets. Natural and dietary compounds provide a resource for the development of potent agents affecting intracellular signaling cascades, and numerous studies have been conducted to evaluate the efficacy of natural products in targeting the Hh signaling pathway. In this review, we summarize the role of Hh signaling in tumorigenesis, discuss results from recent studies investigating the effect of natural products and dietary components on Hh signaling in cancer, and provide insight on novel small molecules as potential Hh signaling inhibitors.

Best Peter

To Read the Article - Click on the Link:

Link: Aberrant Hedgehog
or Go To
http://rvaprostatecancersupport.org/PDF/1 27 20 PCa-Hedgehog Signaling in Cancer by Natural and diet.pdf

*

CRPC produced by ADT treatment of Hormone Sensitive Cancers

RVA - Us Too Warriors:

The attached papers indicated CRPC produced by ADT treatment of hormone sensitive cancers makes the cancer grow by increasing prolactin which can be blocked by drugs that block prolactin, Cabergoline (dostinex) or bromocriptine, to possible put the CRPC cancer in remission.
Best Peter

To Read the Articles - Click on the Links:

Link: Clioquinol
or Go To
http://rvaprostatecancersupport.org/PDF/1 26 20 PCa-Clioquinol.pdf

Link: PCa-prolactin
or Go To
http://rvaprostatecancersupport.org/PDF/1 26 20 PCa-prolactin.pdf

Link: PCa-Termination
or Go To
http://rvaprostatecancersupport.org/PDF/1 26 20 PCa-Termination of Untreatable Androgen-independent Prostate cured with Cabergoline.pdf

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Naturally occurring anti-cancer agents targeting EZH2

RVA - Us Too Warriors:

Some of you may be using metformin because of Pre or Diabetes or to reduce your blood sugar to fight PCa. And a few because of NIH clinic study using it with Casodex with metformin which I put you on to and is working for at least four men in our group(including me)! The attachment will show research to develop a drug to block EZH2 growth pathway and natural agents I have been recommending (curcumin and berberine etc) that make metformin more effective in blocking this Pathway.

Abstract:
Natural products are considered as promising tools for the prevention and treatment of cancer. The enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase unit of polycomb repressor complexes such as PRC2 complex that has oncogenic roles through interference with growth and metastatic potential. Several agents targeting EZH2 has been discovered but they often induce side effects in clinical trials. Recently, EZH2 has emerged as a potential target of natural products with documented anti-cancer effects and this discloses a new scenario for the development of EZH2 inhibitory strategies with agents with low cytotoxic detrimental effects. In fact, several natural products such as curcumin, triptolide, ursolic acid, sulforaphane, davidiin, tanshindiols, gambogic acid, berberine and Alcea rosea have been shown to serve as EZH2 modulators. Mechanisms like inhibition of histone H3K4, H3K27 and H3K36 trimethylation, down-regulation of matrix metalloproteinase expression, competitive binding to the S-adenosylmethionine binding site of EZH2 and modulation of tumor-suppressive microRNAs have been demonstrated to mediate the EZH2-inhibitory activity of the mentioned natural products. This review summarizes the pathways that are regulated by various natural products resulting in the suppression of EZH2, and provides a plausible molecular mechanism for the putative anti-cancer effects of these compounds.

Best Peter

To Read the Articles - Click on the Links:

Link: Anti-cancer Agents
or Go To
https://www.sciencedirect.com/science/article/abs/pii/S0304383517301842

*
Urologic Surgery and Mechanisms of Therapeutic Resistance

RVA - Us Too Warriors:

Some interesting research follows that you can apply to your fight.

Message from the Director of Research
"We are the one of the largest urologic research programs in the nation with six research laboratories and over $4 million in research grants in 2014."
Allen C. Gao, M.D., Ph.D. - Director of Research -Department of Urologic Surgery
and Suppressing the nuclear receptor protein ROR-?; with small-molecule compounds can reduce androgen receptor (AR) levels in castration-resistant prostate cancer and stop tumor growth.

and

Mechanisms of Therapeutic Resistance in Prostate Cancer

Abstract:
Abstract Prostate cancer is the second leading cause of cancer deaths in the USA. The challenge in managing castration-resistant prostate cancer (CRPC) stems not from the lack of therapeutic options but from the limited duration of clinical and survival benefit offered by treatments in this setting due to primary and acquired resistance. The remarkable molecular heterogeneity and tumor adaptability in advanced prostate cancer necessitate optimization of such treatment strategies. While the future of CRPC management will involve newer targeted therapies in deliberately biomarker-selected patients, interventions using current approaches may exhibit improved clinical benefit if employed in the context of optimal sequencing and combinations. This review outlines our current understanding of mechanisms of therapeutic resistance in progression to and after the development of castration resistance, highlighting targetable and reversible mechanisms of resistance.

Best Peter

To Read the Articles - Click on the Links:

Link: Urologic Surgery
or Go To
http://rvaprostatecancersupport.org/PDF/1 19 20 Message.pdf

To read Mechanisms of Therapeutic Resistance in Prostate Cancer
Click on the Link:

Link: Therapeutic Resistance
or Go To
http://rvaprostatecancersupport.org/PDF/1 19 20 PCa-Mechanisms.pdf

*

New York Times Editorial and the Apple Watch

RVA - Us Too Warriors:

The two articles "New York Times Editorial on The FDA" and the "Apple Watch" - “how good it is for cardiac issues.”

Andre’ has the Apple Watch Series 4 which is the first watch with the ECG feature and the BPM feature. The Apple Watch Series 5 starts at $400. I don’t know if the Series 4 is still sold, however, it may be available at retailers such as Best Buy and Costco.

Thank You Andre’ for providing this information

To Read the Articles - Click on the Link:

Link: FDA
or Go To
http://rvaprostatecancersupport.org/PDF/11720FDA-Opinion.pdf

Link: Apple Watch

http://rvaprostatecancersupport.org/PDF/11720TheWatch.pdf
*

Diet and Exercise

RVA - Us Too Warriors:

In winter it is important to focus on Diet and Exercise because it is harder to get outside and vegetables are needed even more but become less available.

Best Peter

To Read the Prostatepedia Article - Click on the Link:

Link: Diet and Exercise
or Go To
http://rvaprostatecancersupport.org/PDF/1 15 20 ProstatepediaDietExercise.pdf

*
Genetics for PCa

Us Too warriors,

Statin use is associated with lower risk of PTEN-null and lethal prostate cancer

Abstract:

Background: Statins are associated with lower risk of aggressive prostate cancer, but lethal prostate cancer is understudied and contributing mechanisms unclear. We prospectively examined statins and lethal prostate cancer risk in the Health Professionals Follow-up Study (HPFS), tested associations with molecular subtypes, and integrated gene expression profiling to identify putative mechanisms. Methods: Our study included 44,126 men cancer-free in 1990, followed for prostate cancer incidence through 2014, with statin use recorded on biennial questionnaires. We used multivariable Cox regression to examine associations between statins and prostate cancer risk overall, by measures of clinically-significant disease, and by ERG and PTEN status. In exploratory analysis, age-adjusted gene set enrichment analysis identified statin-associated pathways enriched in tumor and adjacent normal prostate tissue.

Results: During 24 years follow-up, 6,305 prostate cancers were diagnosed and 801 (13%) were lethal (metastatic at diagnosis or metastatic/fatal during follow-up). Relative to never/past use, current statin use was inversely associated with risk of lethal prostate cancer (HR 0.76; 95%CI 0.60-0.96) but not overall disease. We found a strong inverse association for risk of PTEN-null cancers (HR 0.40; 95%CI 0.19-0.87) but not PTENintact cancers (HR 1.18; 95%CI 0.95-1.48; p-heterogeneity=0.01). Associations did not differ by ERG. Inflammation and immune pathways were enriched in normal prostate of statin ever (n=10) versus never users (n=103).

To Read More - Click on Our Link

Link: Genetics
or Go To
http://rvaprostatecancersupport.org/PDF/1 12 20 Allott-2019-Statin-use-is-associated-with-lower.pdf

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BREAKING NEWS: Prostate Cancer Deaths To Hit Highest Numbers in Two Decades
Us Too warriors,

WASHINGTON, D.C. – Despite most cancers seeing a drop in deaths, prostate cancer deaths are on the rise in the U.S. New reporting from the American Cancer Society shows that in 2020, the number of men who will die from prostate cancer will hit a record high over the last two decades, with an increase of 5 percent since just last year.

The annual report – Cancer Facts and Figures – was released earlier today, and states that disease reductions “halted” for prostate cancer. Other troubling findings include a prediction that in 2020, prostate cancer will receive the most diagnoses among male cancers, with 21 percent of new cancer cases being prostate-related, compared to the next highest, lung and bronchus, at only 13 percent. Of those diagnosed with prostate cancer, 10 percent are expected to pass away from the disease.

To Read More - Click on Our Link

Link: Prostate Cancer Deaths
or Go To
https://zerocancer.org/zeronews/2020rates/

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Enzalutamide induces PSMA upregulation

Us Too warriors,

Abstract
PURPOSE:
There is preliminary evidence for prostate-specific membrane antigen (PSMA) upregulation effects of androgen receptor blockade in prostate cancer. In an attempt to find the best condition for PSMA radioligand therapy in metastatic castration-resistant prostate cancer (mCRPC) patients, we evaluated the effect of oral enzalutamide in patients, predominantly having previously progressed on enzalutamide treatment.

To Read More - Click on Our Link

Link: PSMA
or Go To
https://www.ncbi.nlm.nih.gov/pubmed/31901103

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A Case of General Fatigue Caused by Enzalutamide that was Evaluated Using the Cancer Fatigue
Scale and Overcome by Switching to Nighttime Treatment

Us Too warriors,
Abstract
An 81-year-old man with castration-resistant prostate cancer experienced general fatigue while receiving enzalutamide treatment. In some patients we encountered the enzalutamide treatment had to be interrupted or the dose decreased because of this adverse effect. We evaluated the patient's general fatigue using the Cancer Fatigue Scale (CFS) score and clarified the quantitative information about his general fatigue. In order to maintain the optimal dose, we advised the patient to take enzalutamide at night. This alleviated the adverse effect, and he could maintain the optimal dose of this medicine. We compared the CFS score before and after switching to nighttime treatment and found improvement. This is the first report of a CFS-based evaluation of the improvement in general fatigue caused by enzalutamide by switching to nighttime treatment.

To Read More - Click on Our Link

Link: Fatigue
or Go To
https://www.ncbi.nlm.nih.gov/pubmed/31902181

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P53 is considered the mother of all anticancer genes

Us Too warriors,
This is the first paper I have seen that claims to fight this defect. P53 is considered the mother of all anticancer genes and when it is knocked out it patients do not farewell.

Inactivation of the p53gene is a key driver of tumorigenesis in various cancer cohorts and types. The quest for a successful p53-based therapy that holds the promise of treating more than half of the cancer population has culminated in extensive knowledgeabout the role and function of p53and led to new proposed innovative strategies against p53-defective cancers. We will discusssome of these latest studies with a focus on metabolic regulation and DNA damage response and also highlight novel functionsof p53in these pathways that may provide a contemporary rationale for targeting p53loss in tumors.

To Read More - Click on Our Link

Link: P53
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478123/pdf/mjz012.pdf

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Repurposing screen identifies Mebendazole as a clinical candidate
to synergize with docetaxel for prostate cancer treatment

Us Too warriors,

BACKGROUND: Docetaxel chemotherapy in prostate cancer has a modest impact on survival. To date, efforts to develop combination therapies have not translated into new treatments. We sought to develop a novel therapeutic strategy to tackle chemoresistant prostate cancer by enhancing the efficacy of docetaxel.
METHODS: We performed a drug-repurposing screen by using murine-derived prostate cancer cell lines driven by clinically relevant genotypes. Cells were treated with docetaxel alone, or in combination with drugs (n = 857) from repurposing libraries, with cytotoxicity quantified using High Content Imaging Analysis.
RESULTS: Mebendazole (an anthelmintic drug that inhibits microtubule assembly) was selected as the lead drug and shown to potently synergise docetaxel-mediated cell killing in vitro and in vivo. Dual targeting of the microtubule structure was associated with increased G2/M mitotic block and enhanced cell death. Strikingly, following combined docetaxel and mebendazole treatment, no cells divided correctly, forming multipolar spindles that resulted in aneuploid daughter cells. Liposomes entrapping docetaxel and mebendazole suppressed in vivo prostate tumour growth and extended progression-free survival.
CONCLUSIONS: Docetaxel and mebendazole target distinct aspects of the microtubule dynamics, leading to increased apoptosis and reduced tumour growth. Our data support a new concept of combined mebendazole/docetaxel treatment that warrants further clinical evaluation.

To Read More - Click on Our Link

Link: Mebendazole
or Go To
http://rvaprostatecancersupport.org/PDF/1 9 20 PCa-mebendazole.pdf

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Phytochemicals and PI3K Inhibitors in Cancer—An Insight

RVA - Us Too Warriors:

Abstract

In today's world of modern medicine and novel therapies, cancer still remains to be one of the prime contributor to the death of people worldwide. The modern therapies improve condition of cancer patients and are effective in early stages of cancer but the advanced metastasized stage of cancer remains untreatable. Also most of the cancer therapies are expensive and are associated with adverse side effects. Thus, considering the current status of cancer treatment there is scope to search for efficient therapies which are cost-effective and are associated with lesser and milder side effects. Phytochemicals have been utilized for many decades to prevent and cure various ailments and current evidences indicate use of phytochemicals as an effective treatment for cancer. Hyperactivation of phosphoinositide 3-kinase (PI3K) signaling cascades is a common phenomenon in most types of cancers. Thus, natural substances targeting PI3K pathway can be of great therapeutic potential in the treatment of cancer patients. This chapter summarizes the updated research on plant-derived substances targeting PI3K pathway and the current status of their preclinical studies and clinical trials.

Best Peter

To Read more on this subject - Click on the Links:

Link: Phytochemicals
or Go To
https://www.researchgate.net/publication/321813034_Phytochemicals_and_PI3K_Inhibitors_in_Cancer-An_Insight

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Melatonin

RVA - Us Too Warriors:

Melatonin May Increase Anticancer Potential of Pleiotropic Drugs

Abstract:
Melatonin (N-acetyl-5-methoxytryptamine) is not only a pineal hormone, but also an ubiquitary molecule present in plants and part of our diet. Numerous preclinical and some clinical reports pointed to its multiple beneficial effects including oncostatic properties, and as such, it has become one of the most aspiring goals in cancer prevention/therapy. A link between cancer and inflammation and/or metabolic disorders has been well established and the therapy of these conditions with so-called pleiotropic drugs, which include non-steroidal anti-inflammatory drugs, statins and peroral antidiabetics, modulates a cancer risk too. Adjuvant therapy with melatonin may improve the oncostatic potential of these drugs. Results from preclinical studies are limited though support this hypothesis, which, however, remains to be verified by further research

Best Peter

Also:
RVA Us Too Warriors, Most of my many antioxidant supplement polyphenols are designed to inhibit IL-6 stimulation of NFkb, But melatonin which I take at very high dose of 40 mg per night is very good at doing this and keeps ARV-7 from making Anti-Androgen therapies like Xtandi, casodex etc from failing from CRPC.
and
Melatonin Inhibits Androgen Receptor Splice Variant-7 (AR-V7)-Induced Nuclear Factor-Kappa B (NF-κB) Activation and NF-κB Activator-Induced AR-V7 Expression in Prostate Cancer Cells: Potential Implications for the Use of Melatonin in Castration-Resistant Prostate Cancer (CRPC) Therapy.

To Read more on these subjects - Click on the Links:

Link: IL-6 Stimulation
or Go To
http://rvaprostatecancersupport.org/PDF/2 8 20 PCa-Melatonin differentiates PCa and slows growth.pdf

Link: Variant-7 (AR-V7)
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485954/#__ffn_sectitle

Link: Anticancer Potential
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320927/

and
Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis

Abstract:
There is highly credible evidence that melatonin mitigates cancer at the initiation, progression and metastasis phases. In many cases, the molecular mechanisms underpinning these inhibitory actions have been proposed. What is rather perplexing, however, is the large number of processes by which melatonin reportedly restrains cancer development and growth. These diverse actions suggest that what is being observed are merely epiphenomena of an underlying more fundamental action of melatonin that remains to be disclosed. Some of the arresting actions of melatonin on cancer are clearly membrane receptor-mediated while others are membrane receptor-independent and involve direct intracellular actions of this ubiquitously-distributed molecule. While the emphasis of melatonin/cancer research has been on the role of the indoleamine in restraining breast cancer, this is changing quickly with many cancer types having been shown to be susceptible to inhibition by melatonin. There are several facets of this research which could have immediate applications at the clinical level. Many studies have shown that melatonin’s co-administration improves the sensitivity of cancers to inhibition by conventional drugs. Even more important are the findings that melatonin renders cancers previously totally resistant to treatment sensitive to these same therapies. Melatonin also inhibits molecular processes associated with metastasis by limiting the entrance of cancer cells into the vascular system and preventing them from establishing secondary growths at distant sites. This is of particular importance since cancer metastasis often significantly contributes to death of the patient. Another area that deserves additional consideration is related to the capacity of melatonin in reducing the toxic consequences of anti-cancer drugs while increasing their efficacy. Although this information has been available for more than a decade, it has not been adequately exploited at the clinical level. Even if the only beneficial actions of melatonin in cancer patients are its ability to attenuate acute and long-term drug toxicity, melatonin should be used to improve the physical wellbeing of the patients. The experimental findings, however, suggest that the advantages of using melatonin as a co-treatment with conventional cancer therapies would far exceed improvements in the wellbeing of the patients.

To Read more on this subject - Click on the Links:

Link: Full Service
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412427/

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Mushroom Consumption
RVA Us Too Warriors:

Mushroom consumption and incident risk of prostate cancer in Japan: A pooled analysis of the Miyagi Cohort Study and the Ohsaki Cohort Study

Introduction
According to Global Cancer Statistics 2018,1 prostate cancer ranks as the second-most frequent cancer and the ﬁfth leading cause of cancer death in men. Although there is no sure way to prevent prostate cancer, maintaining healthy eating habits (e.g., consuming more vegetables and fruits) has been suggested as an approach that might lower the risk of prostate cancer.

Mushrooms have a long history of being consumed as food and used in Asian medicines. However, research on the health effects of mushrooms has only emerged and been developed in recent decades. To date, an increasing number of in vivo and in vitro studies have suggested the beneﬁcial effects of mushrooms on health, such as antioxidation, anti-inﬂammation, immunomodulation, etc.

Additionally, mushrooms also reportedly have anticancer properties and effects against tumor development.In vivo and in vitro evidence has shown that mushrooms have the potential to prevent several kinds of cancers (e.g., those of the breast, bladder, colon and lung), including prostate cancer. Extracts of mushrooms such as Agaricus blazei Murill, Agaricus bisporus, Trametes versicolor, Cordyceps militaris and Coprinus comatus were suggested to inhibit cell proliferation in human prostate cancer cell lines and to restrict prostate tumorigenic progression from the hormone-dependent to the hormonerefractory state.

To Read more on this subject - Click on the Link:

Link: Mushroom
or Go To
http://rvaprostatecancersupport.org/PDF/12 15 19 Zhang_et_al-2019-International_Journal_of_Cancer.pdf

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Pterostilbene
RVA Us Too Warriors:

Pterostilbene in Blueberries vs Resveratrol in Grape Skins. It seems Pterostilbene is more bioavailable than Resveratrol and may be a better Resveratrol.

Best Peter

To Read more on this subject - Click on the Link:

Link: Pterostilbene
or Go To
http://www.pterostilbene.com/

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Recruitment of miR-8080 by luteolin inhibits androgen receptor splice variant 7
expression in castration-resistant prostate cancer.

RVA Us Too Warriors:

A need exists for seeking effective treatments for castration-resistant prostate cancer (CRPC) in response to its emergence following androgen deprivation therapy as a major clinical problem. In the present study, we investigated the chemopreventive and chemotherapeutic potential of luteolin, a flavonoid with antioxidative properties, on prostate cancer, including CRPC.

Best Peter

To Read more on this subject - Click on the Link:

Link: luteolin
or Go To
https://www.ncbi.nlm.nih.gov/pubmed/31805186

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Dementia and Depression
RVA Us Too Warriors:

Risk of Dementia and Depression in Young and Middle-aged Men Presenting with Nonmetastatic Prostate Cancer Treated with Androgen Deprivation Therapy.

BACKGROUND: Previous studies have found an association between androgen deprivation therapy (ADT) and an increased risk of dementia and depression in elderly men. This association remains controversial, and little is known about the effects of ADT in younger men.

OBJECTIVE: To examine the association between the receipt of ADT and these outcomes in young men aged 40-64 yr presenting with nonmetastatic prostate cancer (PCa).

Best Peter

To Read more on this subject - Click on the Link:

Link: Dementia and Depression
or Go To
https://www.ncbi.nlm.nih.gov/pubmed/31624049

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Cabazitaxel
RVA Us Too Warriors:

Overall and progression-free survival with cabazitaxel in metastatic castration-resistant prostate cancer in routine clinical practice: the FUJI cohort.

BACKGROUND: Cabazitaxel is a treatment of metastatic castration-resistant prostate cancer (mCRPC) after docetaxel failure. The FUJI cohort aimed to conﬁrm the real-life overall and progression-free survival (OS, PFS) and safety of cabazitaxel.
METHODS: Multicentre, non-interventional cohort of French mCRPC patients initiating cabazitaxel between 2013 and 2015, followed 18 months.
RESULTS: Four hundred one patients were recruited in 42 centres. At inclusion, median age was 70, main metastatic sites were bones (87%), lymph nodes (42%) and visceral (20%). 18% had cabazitaxel in 2nd-line treatment, 39% in 3rd-line and 43% in 4th-line or beyond. All had prior docetaxel, and 82% prior abiraterone, enzalutamide or both. Median duration of cabazitaxel treatment was 3.4 months. Median OS from cabazitaxel initiation was 11.9 months [95% CI: 10.1–12.9]. In multivariate analyses, grade≥3 adverse events, visceral metastases, polymedication, and >5 bone metastases were associated with a shorter OS. Main grade≥3 adverse events were haematological with 8% febrile neutropenia.
CONCLUSION: Real-life survival with cabazitaxel in FUJI was shorter than in TROPIC (pivotal trial, median OS 15.1 months) or PROSELICA (clinical trial 20 vs 25mg/m2, median OS, respectively, 13.4 and 14.5 months). There was no effect of treatment-line on survival. No unexpected adverse concerns were identiﬁed. STUDY REGISTRATION: It was registered with the European Medicines Agency EUPASS registry, available at www.encepp.eu, as EUPAS10391. It has been approved as an ENCEPP SEAL study.
Best
Peter

To Read more on this subject - Click on the Link:

Link: Cabazitaxel
or Go To
http://rvaprostatecancersupport.org/PDF/11 29 19 Rouyer-2019-Overall-and-progression-free-surviv.pdf

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Onvansertib/Abiraterone Stabilizes PSA in 75 Percent of Patients With mCRPC
RVA Us Too Warriors:

The combination of onvansertib (PCM-075) with abiraterone acetate (Zytiga) decreased the prostate-specific antigen (PSA) levels in most of the evaluable patients treated in a phase II study (NCT03414034), which used the combination in adult patients with metastatic castration-resistance prostate cancer (mCRPC), according to a press release from onvansertib developer, Trovagene, Inc.1

Best Peter

To Read more on this subject - Click on the Link:

Link: Onvansertib/Abiraterone
or Go To
https://www.targetedonc.com/news/onvansertibabiraterone-stabilizes-psa-in-75-percent-of-patients-with-mcrpc

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Highlights of Natural Products in Prostate Cancer Drug Discovery
RVA Us Too Warriors:

Where does it all come from:

1. Introduction - The remarkable impact of natural products (NPs) in the quest for new agents and new directions in medicinal discovery is well established. The exploration of Nature as a source of novel active agents that may serve as leads and scaffolds for drugs targeting a myriad of diseases and the use of synthetic organic chemistry to modify them have been a driving force for drug discovery.

2. Natural products and cancer - Over the course of millennia, natural compounds have evolved into specific scaffolds that interact with cellular macromolecules (Clardy & Walsh, 2004). Such scaffolds can be used as templates and fine-tuned by medicinal chemists to produce novel compounds with therapeutic applications.

Best Peter

To Read more on this subject - Click on the Link:

Link: Natural Products
or Go To
http://rvaprostatecancersupport.org/PDF/11 26 19 PCa-Natural Products in PCa related Pten neagative and othe conditions.pdf

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Everyday Urology - Volume 4, Issue 3

From the Desk of the Editor: Volume 4, Issue 3

Welcome to Everyday Urology - Oncology Insights. As is our journal’s goal, this issue will illuminate recent advances within the management armamentarium of Urologic Oncology by featuring clinical care updates and expert opinions. In this issue, Everyday Urology focuses on advanced prostate cancer, highlighting recent additions to the nmCRPC treatment landscape as well as the emerging role of theranostics. Finally, our spotlight features coverage of the Advanced Prostate Cancer Consensus Conference, (APCCC 2019) held August 29 - 31, 2019 in Basel, Switzerland.

Click on the Link to Read more:

Link: Issue 3
or Go To
https://www.urotoday.com/journal/everyday-urology-oncology-insights.html
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Clinical Features of Neuroendocrine Prostate Cancer

Highlights

•Neuroendocrine prostate cancer (NEPC) may arise de novo or develop in the later stages of castration-resistant prostate cancer as a mechanism of resistance.
•NEPC is associated with low PSA and frequent visceral metastases.
•Small-cell carcinoma is associated with worse overall survival than mixed histology.
•RB1 and TP53 loss in both de novo and treatment-related NEPC harbours poor outcome.

To read more on this subject:

Link: Neuroendocrine
or Go To
https://www.ejcancer.com/article/S0959-8049(19)30471-X/abstract

*
Calculator

RVA Warriors:

The Website Calculator below shows the chances of PCa for men not diagnosed yet or it can be used to see what your chancers were when you were diagnosed based on your information then. My information at age 54 years old when diagnosed suggested I had a 9% chance of aggressive cancer and a 11% of not aggressive cancer. This is a high ratio of aggressive cancer which I turn out to have -- Peter Moon PhD

To go to the Calculator use our Link:

Link: Calculator
or Go To
http://www.prostatecancer-riskcalculator.com/seven-prostate-cancer-risk-calculators

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Genomic Drivers of Poor Prognosis

US Too Warriors:

The paper below is helpful if you have progressed to advanced cancers - It will help you to navigate what treatments may still work. We have men in our group who are making the decision on their next treatments after failure on Xtandi or Zytiga. Please keep them in your thoughts and prays.
Enjoy the gift of this beautiful Day -- Peter Moon PhD

To read more on this subject:

Link: Drivers
or Go To
http://rvaprostatecancersupport.org/PDF/10 4 19 j.eururo.2019.03.020.pdf

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Precision Medicine

US Too Warriors:

The attached paper is a follow up to my talk last night on Purpose of my Talk to get you to "Learning your Mutations in Your cancer so you can find a treatment/doctor who can/will treat you with a drug targeted at your mutation = Precision Medicine.!!!!
Not to give you the standard of Care that is 30 years out of date.

To read more on this subject:

Link: Precision Medicine
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483502/

Link: Detection
or Go To
http://rvaprostatecancersupport.org/PDF/ 9 14 19 PP-Gene Analysis IS Imperative Us Too Sept19, 2019 PDF.pdf

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2019 Annual Meeting of the American Society for Radiation Oncology

ASTRO 2019: Hormone Therapy Increase Mortality in Select Patients Undergoing Prostate Cancer Salvage Radiotherapy

September 15, 2019—Chicago, Illinois—Prolonged hormone therapy is more harmful than beneficial for men with recurring prostate cancer and low prostate-specific antigen (PSA) levels, according to a secondary analysis of a recent clinical trial that changed the standard of care.

To Read more on this subject - Click on Our Link:
Link: Hormone Therapy
or Go To
https://www.practiceupdate.com/news/26591/32/1?elsca1=emc_conf_ASTRO2019During-1&elsca2=email&elsca3=practiceupdate_onc&elsca4=201982_ASTRO2019During-1&elsca5=conference&rid=NTU2MjE4MTA4NzMS1&lid=10332481

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A Way Around Lupron

Us Too warriors,
See Uva research paper attached after the news release that may promise a way around Lupron for advanced cancer.
and UVA discovers incredible HULLK that controls prostate cancer progression.
Peter

To Read more on this subjects:
Click on Our Links
Link: A Way Around Lupron
or Go To
http://rvaprostatecancersupport.org/PDF/8 1 19 PCa.pdf

Link: HULLK
or Go To
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-019-1039-6

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AGEs

Advanced glycation end-products:

Dr David P. Turner - Associate Professor
Director of shRNA Technology and AGE analysis Shared Resources
Department of Pathology and Laboratory Medicine
The James E. Clyburn Research Center - Medical University of South Carolina
Charleston, SC 29425 - Office: BE407 - Office Phone: (843) 876-2309
Laboratory: BE428 - www.agekills.org

Dr David Turner. Ph.D. of the Medical University of South Carolina gave a Presentation on AGEs on 7/20/19 at the
"Men's Health Conference: Prostate Cancer Summit at the Quioccasin Baptist Church - Richmond Va

Advanced glycation end-products:
A biological consequence of lifestyle contributing to cancer disparity David P. Turner Department of Pathology & Laboratory Medicine, Hollings Cancer Center; Medical University of South Carolina, Charleston, SC 29425 Abstract Low income, poor diet, obesity and a lack of exercise are inter-related lifestyle factors that can profoundly alter our biological make-up to increase cancer risk, growth and development. We recently reported a potential mechanistic link between carbohydrate derived metabolites and cancer which may provide a biological consequence of lifestyle that can directly impact tumor biology. Advanced glycation end-products (AGEs) are reactive metabolites produced as a byproduct of sugar metabolism. Failure to remove these highly reactive metabolites can lead to protein damage, aberrant cell signaling, increased stress responses, and decreased genetic fidelity. Critically, AGE accumulation is also directly affected by our lifestyle choices and shows a race specific, tumor dependent pattern of accumulation in cancer patients. This review will discuss the contribution of AGEs to the cancer phenotype with a particular emphasis on their biological links with the socioeconomic and environmental risk factors that drive cancer disparity. Given the potential benefits of lifestyle changes and the potential biological role of AGEs in promoting cancer, opportunities exist for collaborations impacting basic, translational, epidemiological and cancer prevention initiatives.

We recently reported a potential mechanistic link between sugar derived metabolites and cancer which may provide a molecular consequence of our lifestyle choices that can directly impact tumor biology and contribute to cancer disparity (4). Advanced glycation end products (AGEs) are reactive metabolites produced during the breakdown of sugar. AGEs accumulate in our tissues and organs over time and contribute to the development and complications associated with diseases of advancing age including diabetes, cardiovascular disease, renal failure, arthritis and neurodegenerative disorders (5). The rate of AGE accumulation in our bodies results from a balance between 1) their endogenous accumulation during the breakdown of sugar via the non-enzymatic, spontaneous glycosylation of proteins, lipids and DNA; 2) their exogenous intake through the foods we consume and other lifestyle factors such as drinking alcohol, smoking and a sedentary lifestyle; and 3) their inefficient removal via renal and/or enzymatic clearance, around 10– 30% of exogenous AGEs are absorbed intestinally but only a third of those are excreted in urine and feces (6). Changes in this dynamic equilibrium, as seen as we grow older or as a consequence of poor lifestyle, causes increased levels of AGE accumulation which promote disease complications and progression.

To Read more on this subject:
Click on Our Link
Link: Manuscript/Report
or Go To
http://rvaprostatecancersupport.org/PDF/7 22 19 Turner 2015 Can Res.pdf

For a better view of the Flyer You see above - Click on Our Link
Link: Flyer
or Go To
http://rvaprostatecancersupport.org/PDF/7 22 19 HCC AGE flyer.pdf

To See The Advanced Glycation End Product (AGE) Content of 549 Foods
(28.35 grams = 1 ounce and 5ml = 1.0144 Tsp)
Click on Our Link
Link: Foods
or Go To
http://rvaprostatecancersupport.org/PDF/07 22 2019 Advanced Glycation End Products in Foods .pdf
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Fenbendazole

US Too Warriors:

I had mentioned in the past meetings that the anti-worm medicine, Niclosamide, was effective in restoring Enzalutamide and Bicalutamide treatment effectiveness after PSA started to rise during treatment. Now another anti-worm medicine, Fenbendazole, is being used by patient self treatment with many types of advanced cancers including PCa -dropping the PSA to Undetectable to put the cancer in remission.

It seems very promising to me; I think the Sun is coming out for all of US.
This is the best news,
Peter

To read more on this subject:
Click on Our Links

Link: Fenbendazole
or Go To
https://www.cancertreatmentsresearch.com/fenbendazole/

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Testosterone Recovery After Cessation of Androgen-Deprivation Therapy for Prostate Cancer

The Journal of Sexual Medicine

US Too Warriors:
This will discuss the recovery in men after ADT treatment.
All best peter

TAKE-HOME MESSAGE

The authors performed a prospective analysis of patients receiving androgen-deprivation therapy (ADT) and the return to baseline testosterone levels. Testosterone levels were measured at baseline and after cessation of ADT. The authors analyzed the testosterone return to castrate level, return to normal level, and return to baseline level. A total of 307 men were included in the study. After 2 years of ADT cessation, testosterone in 8% of men remained at the castrate level, the level returned to normal (>300 ng/dL) in 76%, and returned to baseline in 51%. Predictors of slow recovery included baseline testosterone <400 ng/dL, ADT duration >6 months, and age >65.

ADT can be the cause of substantial undesirable side effects. Appropriate counseling prior to initiation of ADT is warranted, including the potentially prolonged effect of ADT on testosterone levels, with only half of patients returning to their baseline levels 2 years after stopping ADT.

To read more on this subject:
Click on Our Link

Link: ADT
or Go To
https://www.practiceupdate.com/content/testosterone-recovery-after-cessation-of-androgen-deprivation-therapy-for-prostate-cancer/85396/55/3/1

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Targeted biopsy of the prostate:
Improvement in detection of high-grade cancer, or the Will Rogers phenomenon?

Click on Our Link to Read more
Targeted Biopsy
or Go To
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/112599-targeted-biopsy-of-the-prostate-improvement-in-detection-of-high-grade-cancer-or-the-will-rogers-phenomenon.html
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Stevia Rebaudiana- It is not just a sugar substitute anymore

Natural antimicrobial agents, which have been used for thousands of years, have been shown to be effective against various pathogens [32]. Many in vitro and clinical studies have demonstrated their effectiveness not only against B. burgdorferi but also against many other pathogens [33–38]. Stevia rebaudiana which belongs to the Asteraceae family is typically referred to as honey leaf or sweet leaf, and due to its natural sweetness, it is used as a natural substitute to synthetic sweetener [39–41]. The leaf extract of Stevia possesses many phytochemicals, which include austroinullin, β-carotene, dulcoside, nilacin, rebaudi oxides, riboflavin, steviol, stevioside, and tiamin with known antimicrobial properties against many pathogens [40, 42, 43]. The role of these compounds is mainly to protect the plant from microbial infection and adverse environmental conditions [38–43]. Stevia is also well known in traditional medicine for its use in treatment of many diseases like diabetes, high blood pressure, and weight loss [44, 45]. In a few clinical studies, it is reported that the phytochemical stevioside reduces blood pressure in patients experiencing mild hypertension and reduces blood glucose levels in type 2 diabetic patients [44, 45]. It was also demonstrated that the patients did not encounter any adverse effects from the use of stevioside [44, 45].

Considering the effectiveness of Stevia leaf extract in laboratory and clinical studies, we evaluated the antimicrobial potential of Stevia (whole leaf extracts) against the Lyme disease causing pathogen, B. burgdorferi, in a goal to eliminate all the different morphological forms in vitro. To effectively evaluate the whole Stevia leaf extract, we compared the antimicrobial effect of Stevia with antibiotics (doxycycline, cefoperazone, daptomycin) and their combination, which were recently found effective against Borrelia persisters.

In this study, we evaluated the effectiveness of whole leaf Stevia extract against B. burgdorferi spirochetes, persisters, and biofilm forms in vitro. The susceptibility of the different forms was evaluated by various quantitative techniques in addition to different microscopy methods. The effectiveness of Stevia was compared to doxycycline, cefoperazone, daptomycin, and their combinations. Our results demonstrated that Stevia had significant effect in eliminating B. burgdorferi spirochetes and persisters. Subculture experiments with Stevia and antibiotics treated cells were established for 7 and 14 days yielding, no and 10% viable cells, respectively compared to the above-mentioned antibiotics and antibiotic combination. When Stevia and the three antibiotics were tested against attached biofilms, Stevia significantly reduced B. burgdorferi forms. Results from this study suggest that a natural product such as Stevia leaf extract could be considered as an effective agent against B. burgdorferi.

Click on Our Link to Read more
Stevia
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681354/
*
Plant Extracts

US Too Warriors:

The figure is from the attached paper (link below). I am using 8 of the 13 supplement extracts portrayed around the outside of the figure that attack the various cancer growth factors portrayed acting on the PCa cell nucleus.
All the best, Peter

To Read more on this subject:
Click on Our Link

Link: Extracts
or Go To
http://rvaprostatecancersupport.org/PDF/6 11 19 Iqbal-2017-Plant-derived-anticancer-agents-a-g-1.pdf

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Testosterone Slows Prostate Cancer Recurrence in Low-Risk Patients

TUESDAY, March 19, 2019 (HealthDay News) -- For patients with localized prostate cancer, testosterone replacement therapy (TRT) slows recurrence, according to a study presented at the annual meeting of the European Association of Urology, held from March 15 to 19 in Barcelona, Spain.

Click on Our Link to Read more
Testosterone
or Go To
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/111033-testosterone-slows-prostate-cancer-recurrence-in-low-risk-patients.html

Hot Sheet

US Too Warriors:
Sign up to get the Hot Sheet newsletters. June 2019 Hot Sheet :

Link: Sign up Hot Sheet
or Go To
https://www.ustoo.org/Read-the-HotSheet-Newsletter

*

Example of the Newsletter's topics in 2018 here you can see some of the archive online.

To See an example:
Click on Our Link

Link: Jan 2018 Hot Sheet
or Go To
http://rvaprostatecancersupport.org/PDF/6419Us-TOO-HotSHEET-January-2018d.pdf

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Mar 2019 - Prostatepedia issue below focuses on treatment issues
for men with an increasing PSA after prostatectomy or prostate radiation

This issue focuses on treatment issues for men with an increasing PSA after prostatectomy or prostate radiation. In this introduction and review are of some basic concepts that should help you follow the discussion more easily.

Click on Our Link to Read more
PSA
or Go To
http://rvaprostatecancersupport.org/PDF/Prostatepedia_V4N7_March2019.pdf
*
Long-term Outcomes of Stereotactic Body Radiotherapy for Low-Risk and Intermediate-Risk Prostate Cancer.

Stereotactic body radiotherapy harnesses improvements in technology to allow the completion of a course of external beam radiotherapy treatment for prostate cancer in the span of 4 to 5 treatment sessions.

Click on Our Link to Read more
Stereotactic
or Go To
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/110247-long-term-outcomes-of-stereotactic-body-radiotherapy-for-low-risk-and-intermediate-risk-prostate-cancer.html
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Jan 2019 - Prostatepedia issue below on Immunotherapy
Link: Jan
or Go To
http://rvaprostatecancersupport.org/PDF/Prostatepedia_January2019_V4N5.pdf

*
Nov Prostatepedia issue below on imaging to detect your cancer so you can pick the best treatments.

Link: Nov
or Go To
http://rvaprostatecancersupport.org/PDF/PCa-Prostatepedia_November2018_V4N3.pdf

The Importance of PSA Doubling Time (PSADT) and Metastases-Free Survival (MFS)
Click on Our Link to read the Article
PSADT
or go to:
https://grandroundsinurology.com/pca-commentary-volume-122-May-2018/

RADIOLIGAND THERAPY (RLT) with 177-LUTETIUM:
Forthcoming Treatment Option Likely to Upgrade the Management of Advanced Prostate Cancer in the Near Future.

Click on Our Link to read the Article
RADIOLIGAND
or go to:
https://grandroundsinurology.com/pca-commentary-volume-123-June-2018/

NEUROENDOCRINE PROSTATE CANCER:
An Adverse Development in Advanced Disease — Which Largely Has Flown Under the Radar.

Click on Our Link to read the Article
NEUROENDOCRINE
or go to:
https://grandroundsinurology.com/pca-commentary-volume-125-August-2018/
DECIPHER AND A HYBRID CLINICAL – GENOMIC CLASSIFIER:
Improving the Prognostic Accuracy of NCCN Risk Categories

Click on Our Link to read the Article
DECIPHER
or go to:
https://grandroundsinurology.com/pca-commentary-volume-127-October-2018/
*
Mouse Study Demonstrates How Nerves Propel Prostate Cancer

Click on Our Link to read the Article
Nerves
or go to:
http://www.einstein.yu.edu/news/releases/1276/study-shows-how-nerves-drive-prostate-cancer/
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Indications for and transitioning to secondary treatment while on

active surveillance for prostate cancer

Abstract: For men with lower risk prostate cancer, there is ever-growing literature that demonstrates the oncologic safety of deferring radical treatment and opting for regular monitoring for disease progression. This strategy’s success is largely owed to appropriate, systematic monitoring protocols that typically employ various prostate specific antigen (PSA) metrics or digital rectal exam (DRE) findings. Novel biologic markers and advanced imaging techniques have shown promise in active surveillance (AS) populations such as for use of patient candidacy as well as detection of disease progression. This review summarizes contemporary surveillance protocols as well as the emerging technologies which demonstrate significant potential to improve such protocols.

Click on Our Link to read the Article
Active
or go to:
http://www.rvaprostatecancersupport.org/PDF/PCa-Acive Surviellance52918.pdf
*
Life Extension Magazine

Destroying the Myth About Testosterone Replacement and
Prostate Cancer By Abraham Morgentaler, MD, Facs

For decades, the medical establishment erroneously conjectured that testosterone replacement therapy increases one’s risk of prostate cancer.

Harvard-based Abraham Morgentaler, MD, FACS, has demonstrated this theory to be mistaken. Contrary to the notion that restoring testosterone to youthful levels is somehow risky, Dr. Morgentaler meticulously shows an increased risk of prostate cancer in aging men with low testosterone. This same information about the dangers of low testosterone was long ago uncovered by the Life Extension Foundation.
Click on Our Link to read this article
Link: Testosterone
or go to:
http://www.lifeextension.com/Magazine/2008/12/Destroying-the-Myth-about-Testosterone-Replacement-Prostate-Cancer/Page-01
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Prostate Cancer Treatment Overview

Prostate Cancer Treatment Guide - This Page will allow you to find and compare the Various Prostate Cancer Treatments.
If you have not made a decision - This is a good place to start.

Click on Our Link for the Prostate Cancer Treatment Guide
Link: Guide
or go to:
http://www.prostate-cancer.com/index.cfm
*
FDG-PET/CT Identifies Patients at Very High Risk for Early Recurrence and Resistance to Castration

TAKE-HOME MESSAGE:

This study sought to determine if 18F-FDG-PET/CT can identify aggressive prostate cancers. A total of 148 consecutive men diagnosed with Gleason 8 or higher prostate cancer on biopsy underwent staging with FDG-PET/CT and bone scan. A high level of intra-prostatic FDG uptake was associated with worse pathologic features at prostatectomy, shorter biochemical recurrence-free survival (median, 11.3 vs 49.5 months), and greater risk for castrate-resistant disease (aHR, 4.02).

FDG-PET/CT may be a useful adjunct to staging CT to guide decision-making as many questions regarding the benefit of surgical management of high-grade prostate cancer remain unanswered.
– Joshua Cohn, MD

Click on Our Link to read this article
Link: FDG-PET/CT
or go to:
https://www.practiceupdate.com/C/66827/56?elsca1=emc_enews_topic-alert#topicAlerts
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Dairy intake after prostate cancer diagnosis in relation to disease-specific and total mortality.

Subject: Milk and Other Dairy Foods in Relation to Prostate Cancer Recurrence

The authors assessed the impact of dairy (specifically whole milk) on the risk of recurrence in patients with prostate cancer (N = 1334). Results showed that men who consumed four or more servings per week of whole milk had a 73% increased risk of recurrence compared with men who consumed fewer than three servings per month. Among very overweight and obese men (BMI ≥27 kg/m2), more than four servings per week vs none to three servings per month of whole milk was associated with a threefold higher risk of recurrence.

Results suggest that whole milk may confer an increased risk of prostate cancer recurrence, especially in obese men. This information should be included in discussions about lifestyle and conservative modifications that may improve a patient's overall cancer risk.

Click on Our Link to read the Abstract
Dairy
or go to:
https://www.ncbi.nlm.nih.gov/pubmed/25989745#
*
Treatment decision incongruence associated with lower health-related quality of life
in prostate cancer survivors. Results from the Picture study: Beyond the Abstract

Subject: What is your method of Making treatment decisions with your Doctor?

Click on Our Link to read the Abstract
Abstract
or go to:
http://www.rvaprostatecancersupport.org/Treatment%20decision%20incongruence%20associated%20with%20lower%20health.pdf
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Princeton University

Subject: A new weapon against bone metastasis?

Promising antibody treatment (15D11) for bone mets that may go to Clinical trial soon???
A new weapon against bone metastasis? Princeton lab develops antibody to fight cancer.

Click on Our Link
Link: Bone Mets
or Go To
https://www.princeton.edu/news/2017/12/11/new-weapon-against-bone-metastasis-princeton-lab-develops-antibody-fight-cancer
*
URO Today

ESOU18: MRI in-bore Guided Biopsies

Amsterdam, The Netherlands (UroToday.com) Dr. Sedelaar gave his perspective of in-bore MRI guided biopsies. The first case reports of in-bore MRI guided biopsies were reported in the year 2000, and recently in 2017, there have been more than 20 publications worldwide, with one series encompassing more than a 1000 patients.

Click on Our Link to read this article
MRI
or go to:
https://www.urotoday.com/conference-highlights/esou18/esou18-prostate-cancer/101469-esou18-mri-in-bore-guided-biopsies.html
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The attached paper discribes the clinical trial on Exercises for Bone Mets.

Us Too Warriors - The attached paper discribes the clinical trial on Exercises for bone mets.
This may be hard to do if you are in pain and if the damage may cause fracture. This study has not been report as it is on going - But it is something to think about doing if you can.

Click on Our Link to read the posts
Blog
or go to:
http://rvaprostatecancersupport.org/PDF/PCa-Bone mets in Backbone Clinical Protocol to analyze Exercise benefits.pdf
*
Snuffy Myers On Immunotherapy For Prostate Cancer

Snuffy Myers On Immunotherapy For Prostate Cancer and other posts on the Prostatepedia Blog.

Click on Our Link to read all the posts
Blog
or go to:
https://www.prostatepedia.net/blogs/prostatepedia
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URO Today Articles of Interest

Active Surveillance: Protecting Patients From Harm
Optimizing Active Surveillance for Prostate Cancer
Magnetic Resonance Imaging-Targeted vs. Systematic Biopsies in Men on Active Surveillance: Results of a Prospective, Randomized Canadian Urology Research Consortium Trial.
Canadian Vs. U.S. Guidelines on Active Surveillance
A Systematic Approach to Discussing Active Surveillance with Patients with Low-risk Prostate Cancer: Beyond the Abstract
What ProtecT Tells Us About Active Surveillance - Session Highlights
Genomic Tests in Active Surveillance and the Role of Hereditary Testing - Session Highlights
Active Surveillance Patient Perspective Question and Answer Panel - Session Highlights
Statin Use and Time to Prostate Cancer Progression in Men Undergoing Active Surveillance
4th ESO Prostate Cancer Observatory: The Urologist’s Perspective on Active Surveillance
Association Between Germline Genetic Variation and Progression in Men with Low-Risk Prostate Cancer on Active Surveillance

Click on Our Link to read all the articles
(Use the search window to find the other articles - copy & paste the title in the window)
URO
or go to:
https://www.urotoday.com/conference-highlights/cua-2017/96650-cua-2017-optimizing-active-surveillance-for-prostate-cancer.html?utm_source=newsletter_5079&utm_medium=email&utm_campaign=optimizing-active-surveillance-for-prostate-cancer-highest-viewer-rated-content-in-2017
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Compare Prostate Cancer Treatments – High Risk
High Risk prostate cancer patients experience the highest range of results and approaches as they are likely to have prostate cancer outside of the prostate. When selecting a course of action, consultations are recommended with a urologist or surgeon, radiation oncologist and medical oncologist. Different treatments have different results and side effects. It is important to understand the potential impact each treatment can have on your quality of life after treatment.

The below link will give you an:
Interactive Comparison Graph - Compare Prostate Cancer Treatments - High Risk Group

Click on Our Link to read the article and use the graph
Graph
or go to:
http://www.pctrf.org/high-risk-results/
*
Surgical Treatment of Male Postprostatectomy Incontinence: Current Concepts.
and
Diminished long-term recovery of peak flow rate (PFR) after robotic prostatectomy in men with baseline PFR <10 mL/s and incidental association with high-risk prostate cancer.
In October 2017, a nonsystematic review of the literature published within the last 2 yr was performed using the PubMed/Medline database. In total, 58 articles were included in the current analysis.
Click on Our Link to read all the articles
Current Concepts
or go to:
https://www.urotoday.com/index.php?option=com_content&view=category&id=1697&utm_source=newsletter_5078&utm_medium=email&utm_campaign=uroalerts-men-s-health-weekly
*
Target definition in salvage postoperative radiotherapy for prostate cancer: 18F-fluorocholine PET/CT assessment of local recurrence.
Abstract:
PURPOSE: Inadequate clinical target volume (CTV) definition is likely to be a major contributing factor to local recurrence (LR) rate after radiotherapy. Our aims were to identify sites of prostate cancer LR in biochemical recurrence post-prostatectomy using 18F-Fluorocholine (18F-FCH) positron emission tomography/computed tomography (PET/CT) and to compare different CTV-delineation guidelines in a cohort of postoperative patients.
Click on Our Link to read more
PET/CT
or go to:
https://www.ncbi.nlm.nih.gov/pubmed/28984165
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August - Prostapedia from Dr. Myers:

"Aggressive Cancers"
In This Newsletter You will find:

In August, we’re talking about what used to be thought of as a rare form of metastatic prostate cancer but now appears to be quite common. In this month’s guest commentary, Dr. Neeraj Agarwal summarizes the problem of neuroendocrine cancer and frames the conversations that follow.

Click on Our Link to read more
Prostapedia
or go to:
http://rvaprostatecancersupport.org/PDF/Prostatepedia_August2017.pdf
*
Article:

"Starving Cancer Cells" By a News Reporter-Staff News Editor at Cancer Weekly
On This Site You will find:

New research from The University of Texas at Austin identifies several natural compounds found in food, including turmeric, apple peels and red grapes, as key ingredients that could thwart the growth of prostate cancer, the most common cancer afflicting U.S. men.

Click on Our Link to read more
Starving
or go to:
http://www.ustoo.org/News-Page/oLV3sHZQWMQtc1carD3dty_0RDcajhv1Qg9LVIP9AQ_SZqyEJjil5giQ9b3kQcI9bzKzSd6kVVYf_79cXYtO3Q
*
Article:

"Mediterranean Herb Guards Vital Liver Functions" By Linda Nevis
On This Site You will find:

The liver performs over 500 life-sustaining functions, including neutralizing toxins.
Milk thistle, a plant native to the Mediterranean regions, has long been prized as a treatment for chronic liver ailments.
Human and animal studies are confirming these benefits.
Click on Our Link to read more
Milk thistle
or go to:
http://www.lifeextension.com/Magazine/2016/5/Mediterranean-Herb-Guards-Vital-Liver-Functions/Page-01
*
Article:

Androgen Receptor Inhibitor - induced "BRCAness" and PARP inhibition
are synthetically lethal for castration-resistant prostate cancer.
On This Site You will find:

Cancers with loss-of-function mutations in BRCA1 or BRCA2 are deficient in the DNA damage repair pathway
called homologous recombination (HR), rendering these cancers exquisitely vulnerable to poly(ADP-ribose)
polymerase (PARP) inhibitors.

Click on Our Link to read more
Androgen Receptor Inhibitor
or go to:
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/95995-androgen-receptor-inhibitor-induced-brcaness-and-parp-inhibition-are-synthetically-lethal-for-castration-resistant-prostate-cancer.html
*
Article:

Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade.
On This Site You will find:

Prostate cancer (PCa) is the most common malignancy among Western men and the second leading-cause
of cancer related deaths. For men who develop metastatic castration resistant PCa (mCRPC), survival is
limited, making the identification of novel therapies for mCRPC critical.

Click on Our Link to read more
Lipid Catabolism
or go to:
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/95534-lipid-catabolism-inhibition-sensitizes-prostate-cancer-cells-to-antiandrogen-blockade.html
*
Article:

Advanced Prostate Cancer Consensus Conference: APCCC
On This Site You will find:

Articles - Video Lectures - Clinical Trials -Centers of Excellence - Conference Highlights - Journal - Calendar

Click on Our Link to read more
Conference
or go to:
https://www.urotoday.com/video-lectures/advanced-prostate-cancer-consensus-conference-apccc.html?utm_source=newsletter_4444&utm_medium=email&utm_campaign=advanced-prostate-cancer-consensus-conference-interviews-with-presenters-by-alicia-morgans-neal-shore-and-charles-ryan
*
Article:

PCa Commentary Vol. #105: FOLLICLE STIMULATING HORMONE (FSH): Its Suppression by Degarelix (Firmagon)
May Contribute to the Drug’s Effectiveness in Androgen Suppression and Its Lesser Cardiotoxicity Compared to Leuprolide (Lupron.)
FOLLICLE STIMULATING HORMONE
or go to:
http://www.pctrf.org/pca-commentary-vol-105-follicle-stimulating-hormone-fsh-suppression-degarelix-firmagon-may-contribute-drugs-effectiveness-androgen-suppression-lesser-cardioto/
*
Article:

Clinical comparison of the efficacy of three different bowel preparation methods on the infectious
complications following transrectal ultrasonography guided prostate biopsy in nursing practice.
Click on Our Link to read more
Infection
or go to:
https://www.ncbi.nlm.nih.gov/pubmed/28401738
*
Article:

Dosimetric impacts of endorectal balloon in CyberKnife stereotactic body radiation therapy
(SBRT) for early-stage prostate cancer.
Click on Our Link to read more
CyberKnife
or go to:
https://www.ncbi.nlm.nih.gov/pubmed/28407345
*
PAN Foundation

The copay assistance program for individuals with metastatic prostate cancer has just opened at the Patient
Access Network (PAN) Foundation. This is a great potential opportunity for eligible men affected by metastatic
prostate cancer to receive up to $12,000 a year in financial assistance.

For more information visit:

Click on Our Link to read more

PAN

or go to:
http://bit.ly/2n1SftA

You may apply online or call 1-866-316-7263.

**********************************

Article:

Two-thirds of Americans see docs who got paid by drug companies: Study
Drexel University Health News, 03/16/2017

About 65 percent of those surveyed as a part of the study by Genevieve Pham–Kanter, PhD, an assistant professor
in Drexel’s Dornsife School of Public Health, visited a doctor within the last year who had received payments or
gifts from pharmaceutical or medical device companies. What’s more: Only 5 percent of those surveyed knew that their
doctor had received such payments.

Click on Our Link to read more

Article

or go to:
https://www.mdlinx.com/family-medicine/medical-news-article/2017/03/16/doctors-payments-from-drug-companies/7087462/

Has Your Doctor Received Drug or Device Company Money?

Click on Our Link to find out

Money

or go to:
https://www.mdlinx.com/family-medicine/news.cfm

*

Scientists use new 'blood biopsies' with experimental device to speed
cancer diagnosis and predict disease spread.

Researchers are using a new blood-analysis technique and tiny experimental device to help physicians predict
which cancers are likely to spread by identifying and characterizing tumor cells circulating through the blood.

Click on Our Link to read more

Blood Biopsies

or go to:
https://www.sciencedaily.com/releases/2017/02/170213091131.htm

*

Life Extension Magazine

How to Reverse Markers of Prostate Cancer.

Despite prostate cancer being the second leading cause of cancer death in men, a raging debate has ensued as
to whether men should have annual PSA blood tests. The scales are tilting in favor of Life Extension®’s
multi-decade campaign to educate men about the importance of regular PSA screening. Not only are there proven
ways to reverse rising PSA levels, but breakthrough treatments can enable safer diagnosis and curative treatment
without the side effects associated with conventional surgery and radiation.

To Read The Articles - Click on Our Link

Life Extension Magazine

or go to:

http://www.lifeextension.com/Magazine/2016/6

*****************************************
URO Today
Your Urology News and Education Resource.

Here you will find Articles, Videos Lectures, Clinical Trials and more. All are Choice topics on Immunotherapy.
Look Around the site & find the Topic that suits your needs by clicking on their links.

UroToday always offers free, open access to all site content - Enter your email address to sign in and
they will send you an Email link to sign in with.

To Read The Articles - Click on Our Link

URO Today

or go to:

https://www.urotoday.com/

Meeting Information for Dec 8 2016

After the Us Too dinner on 12/8/2016 there will be a discussion on
"Preventing PCa Metastasis by Blocking MMPs

To get up to speed - Read the below - Click on Our Link

MMPs

or go to

href="http://www.jamersonscrafts.com/Pictures/PDF/Prevent PCa Metastasis by Blocking MMPs.pdf

Meeting Handout for Nov 17 2016

Us Too Warriors, We hope you can come to the meeting and bring
a copy of the handout covering ADT and its Possible Problems:

Cognitive – Depression, Stress, Alzheimer’s, Parkinson’s increase, Headache
Metabolic- Weight gain, Muscle mass loss, Fat mass up, Lipids LDL +/HDL -, TriGly. +, Diabetes
Physical- Fatigue, Muscle weakness, Falls, BMD -, Fractures, B. +, Sex organs –, ED, Hot Flashes
Heart - Heart disease ~+20 to 40 % if already precent, Diabetes, Insulin resistance.

To Read and print this Handout - Click on Our Link

Handout

or go to
href="http://www.jamersonscrafts.com/Pictures/PDF/Us Too Warriors Nov17 2016.pdf