PetersNotes

Prostate Cancer Support Group - Richmond, Va

Meeting Dates - 3rd Thurs. each month - Time 7:00 PM - No July Meeting - The Dec. date will vary - Call for details - Peter C. Moon Phd. at 804-387-2151 between 7 - 11:00 PM - Location - Ridge Baptist Church, 1515 Eastridge Road Richmond, VA 23229

Vet

Rva Prostate Cancer Support Group

www.rvaprostatecancersupport.org

RVA

Peter's Notes Page

In good faith, this website was created to furnish you with helpful information. Nevertheless, no one who contributes or posts information to this website makes any guarantee regarding the information provided. Any decisions that you make regarding your health should be made in consultation with a qualified healthcare provider.

Affiliated with Us-TOO International Prostate Cancer Education & Support Network

Us Too International

Other Support Groups

Facts and Stats

Emerging Treatments

Complementary
Alternative Treatment Sources

**************************************************
Hi All

Great News - Peter is Home and not in the Hospital.

(The below is one more glimpse into Peter's journey.)
*
Natural products that help treat Castration resistant PCa - Many of These can be found at Swanson Inc or LEF.org

US Too Warriors:

Researchers have demonstrated the anti-PCa properties of several natural products such as curcumin, resveratrol, lycopene, apigenin, quercetin, fisetin, luteolin, kaempferol, genistein, berberine, ursolic acid, eugenol, gingerol, ellagic acid, silibinin A, silibinin B, and epicatechin-3-gallate, both in vitro and in vivo, by their effects on cyclooxygenases, lipoxygenases, and phospholipase A2 (Sarkar et al., 2010; Tewari et al., 2019; Fontana et al., 2020; Marzocco et al., 2021).
Best
Peter
Website
Link: Natural products
or Go To
https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.745177/full

*
Use of Doxycycline to treat Alzheimer's and prostate cancer

US Too Warriors:

I have been taking Doxcycline, 100mg, one pill a day to block MMPs (matrix metalloproteinases) in my body from breakdowning the extracellular matrix proteins in my body to prevent the cancer from escaping into my blood vessels and causing metastasis elsewhere in my body for 24 years. Information below indicates it may also treat Alzheimers. I had Brother Don (31 yrs with PCa) on this for a few years about 2012. And Brother, David (6 years with PCa active Surveillance of PC and 22 years with high grade PINS who has been doing doxycycline for a few years now. I think Brother Don should go back on doxycycline both for his Brain and Cancer. His cancer is at the end stage so he has had Lu 177 recently PSA a little below 90.
Best
Peter

To read more on this subject:

Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity

Link: Doxycycline
or Go To
https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.635760/full

*
The benefit of LU 177 Treatment research paper reports that the benefit in the trial correlated with the drop in PSA with the treatment

US Too Warriors:

Jerry Deans had this treatment but it did not help him because he had a mutation that inactivates his P53 gene which when active is our best protector from cancer
See paper below on Lu 177 trial.
Best
Peter

To read more on this subject:

Association of Declining Prostate-specific Antigen Levels with Clinical Outcomes in Patients with Metastatic Castration-resistant Prostate Cancer Receiving [177Lu]Lu-PSMA-617 in the Phase 3 VISION Trial

Link: LU 177
or Go To
https://www.sciencedirect.com/science/article/pii/S0302283824025600

*************************************************
Research information on detection of How prone one may be to Stroke by measuring blood flow on holding one's breath

US Too Warriors:

We are all prone to health problems besides Cancers. Today I had a call from a friend in our group who had a stroke in July and is recovering. But his memory has suffered. Another member sent me the email info below which is promising. This is a concern of mine because of my family history of neurological problems. I take supplements for brain/memory issues if you want me to send them your way as an email to my stroke friend send me an email.
Best
Peter

To read more on this subject:

Link: Research
or Go To
https://www.msn.com/en-us/health/other/new-laser-headset-assesses-stroke-risk-in-real-time/ar-AA1rAnU7?ocid=BingNewsVerp

* ***************************************************
Website discussing how treatment results may be predicted by PSMA Scan Levels

US Too Warriors:

Warriors, my PSMA scan levels were low which suggest my cancer may not respond well to SBRT which I want to use if My cancer shows up on an Axumin scan that I have scheduled next Month at VCU so I am going to look for supplements or other ways to make my cancer better able to respond to SBRT.
Best
Peter

To read more on this subject:

Link: Treatment Sensitivity
or Go To
https://www.urologytimes.com/view/psma-levels-linked-to-tumor-biology-treatment-sensitivity-in-treatment-na-ve-prostate-cancer

*
The Attached Paper Supports My Iron And Casodex Treatment For My Crpca.

US Too Warriors:

This Paper May Help You To Get Your Doctor To Initiate This Treatment If Yours Is Not Working ? Remember Iron Is A Double Edged Sword - Too Little Is A Cause Of Anemia And Too Much Is Bad For The Brain Among Other Problems So You Need To Titrate The Iron Supplement Amount To Your Needs/Diet By Getting Iron Test Periodically. My Thinking For Men That Would Be Best To Have A Hemoglobin (Red Blood Cell) Level Between 12.5 And 14.5 Ideally. Mine Is 11.4 And Seems To Be Working. I Found That With My Iron Sulfate Pills Level(762 Mg Of Which Is 130 Mg Of Iron) At Two Pills Per Night Is Working. But I Research Iron Blockers I Am Taking At The Same Time And Found That The Doxycycline 100mg, Metformin 100 Mg And Proscar 5 Mg Are Iron Blockers To The Extent That My Iron Saturation Fell From 30% T0 20% Over The Last 2 Months Even With 2 Iron Pills/Night. I Am Switching The Time To Take These Pills So The Blockers Are Not In My Guts At The Same Time As My Iron Pills. I Check My Iron Levels To Be Sure I Do Not Have Iron Overload! Life Is Complicated But That Is What Makes It Interesting. See Paper Below
Best
Peter

To read more on this subject:

Link: Iron And Casodex Treatment
or Go To
https://aacrjournals.org/clincancerres/article/26/23/6387/82882/Iron-Induces-Cell-Death-and-Strengthens-the

*
It appears that some of the heart medicines and Supplements and Good Foods can cause easier Bruising

US Too Warriors:

Some things- drugs, supplements and foods that help the heart by preventing clots make for easier bruising on the rest of your body.

I have experienced this from my Statin, Supplements and foods as mentioned in the article ( I take most all of them) . I am not sure how I am going to modify my drugs/supplements and foods etc because my mom, sister and one of my brothers have had mini-strokes by my age (85) I have not. So it seems to be a family condition where excess clotting is more of a problem than some bruising. Anyway I hope this helps you decide what is best for you.
Best
Peter

To read more on this subject:

Link: Bruising
or Go To
https://www.goodrx.com/drugs/side-effects/easy-bruising-for-no-reason-medication-side-effect

***********
My (PCMoon's) plans for possible Ferroptosis treatment of PCa

US Too Warriors:

I am trying to pursue a Ferroptosis treatment with possible radiation therapy for my prostate cancer if I can find it (the location). It did not show up on PSMA scans when my psa was ~2.0. I am considering asking My oncologist for an FDG scan to find it and if so maybe to follow with SBRT treatment with Ferroptosis promoting drugs. For now I am pursuing Ferroptosis with Iron Sulfate and Casodex. I am waiting for the return of my blood tests PSA after two months to see if it moves the needle in the right direction. The Iron has helped with anemia (9.7 to12.2 Red blood cell) and high C-reactive protein (5.0 to 0.49) from the psoriasis inflammation so far. See papers below for Ferroptosis treatments in Cancers. It appears one of the ways Radiation may work is to cause Ferroptosis without any additional agents but just as a result of the radiation alone???

Best
Peter

Abstract
The incidence of prostate cancer is the second most among male cancers after lung cancer. Prostate cancer develops rapidly and is inclined to metastasize, and castration-resistant prostate cancer (CRPC) can be formed in the later stage, which brings great challenges to the prognosis and treatment. At present, the main treatment of prostate cancer is generally divided into four methods: surgery, chemotherapy, radiotherapy and endocrine therapy. However, the efficacy of these methods fails to satisfy the demands of patient prognosis. Ferroptosis is a newly discovered iron-dependent process, characterized by lipid peroxidation. Ferroptosis is associated with many diseases, especially tumor growth. In recent years, inhibiting tumor growth and overcoming tumor drug resistance by inducing ferroptosis has become a hot research topic. Previous studies have shown that induction of ferroptosis may be a new treatment for prostate cancer. We review the research progress of ferroptosis in prostate cancer in order to provide highly effective therapies for patients with prostate cancer.

Link: Ferroptosis
or Go To
https://www.nature.com/articles/s41391-022-00583-w

*
ADT treatment with Lupron lowers Testosterone towards Zero,
But Testosterone is needed block Brain Plaque to stop Alzheimer's

Us Too Warriors,

I am checking my free and total Testosterone to see if it is still high about 700 to 900. If not I may tryTestosterone patches but will keep an eye on my PSA to be sure it does not activate my PCa.

Best
Peter

Info:

Researchers are searching for a better way to understand why many men with prostate cancer end up with Alzheimer's disease, and whether it's the standard hormone therapy treatment or an overactive immune response that actually contributes to the problem.

Link 1 : " Testosterone"

or Go To

https://www.sciencedaily.com/releases/2024/08/240829132520.htm
*
NEW Flash (Takes only Seconds) High Proton beam radiation treat for cancer being research
at U of Penn. head to Clinical trial this year!

Us Too Warriors,

The best we have now is SBRT x-rays of which I had 8 different treatments on my Melanoma Mets.
Some were shots for about half an hour on three separate days. Somewhere where one shot on one day.
All designed to be enough to kill the cancer with minimum damage to good tissue. I have no bad effects
I know of from this treatment With Dr. Cuttno at Forest hospital Cannon Radiation center.
>
The Flash treatment has been tested on Animals for several years and seems to work well.

Best
Peter

Info:

Researchers at Penn Medicine are pioneering a new type of radiation therapy that could force textbooks to be rewritten. For decades, the concept of “fractionation” has been dogma in radiation oncology. A total dose of radiation is divided into smaller doses, or fractions, delivered to the patient in a series of treatments over days or weeks. But an experimental new form of radiation, known as FLASH, upends that tried-and-true approach. “The traditional idea is that by fractionating radiation, we can kill tumor cells while sparing healthy tissue. FLASH turns this idea on its head,” said Constantinos Koumenis, PhD, the Richard H. Chamberlain Professor of Radiation Oncology at Penn Medicine.

Link 1 : " Flash"

or Go To

https://www.pennmedicine.org/news/publications-and-special-projects/penn-medicine-magazine/spring-summer-2024/flash-forward-to-an-ultra-fast-new-form-of-radiation
*
Dr Snuffy Meyers died from Parkinson's Disease which may have been caused
by the ADT for PCa which he had in his fifties? Website Paper

Us Too Warriors,

Warriors, See website Links below. Another reason I have avoided ADT treatment for its many other possible bad side effects.

Best
Peter

Info:

The magnitude of excess risk ranged from 20% for dementia to 66% for depression. The risk of Alzheimer's disease, vascular dementia, and Parkinson's disease were all significantly increased among men exposed to ADT versus those who did not receive the hormonal therapy, including those with and without prostate cancer.

Link 1 : "ADT"

or Go To

https://www.google.com/search?q=adt+and+parkinson%27s+disease&sca_esv=5af0601d0d0f13a8&rlz=1C1CHBF_enUS819US819&ei=QlrDZv7CNtWi5NoP142OiQg&ved=0ahUKEwj-65zApYGIAxVVEVkFHdeGI4EQ4dUDCBA&oq=adt+and+parkinson%27s+disease&gs_lp=Egxnd3Mtd2l6LXNlcnAiG2FkdCBhbmQgcGFya2luc29uJ3MgZGlzZWFzZTIIEAAYgAQYogQyCBAAGKIEGIkFMggQABiABBiiBDIIEAAYgAQYogQyCBAAGIAEGKIESPtrUMYOWNEYcAF4AJABAJgBW6ABqAGqAQEyuAEMyAEA-AEBmAIDoAK9AcICDhAAGIAEGLADGIYDGIoFwgILEAAYgAQYsAMYogTCAgYQABgHGB7CAggQABgHGB4YD5gDAIgGAZAGCZIHATOgB_gN&sclient=gws-wiz-serp

*
Website for Paper on the Prospects for Developing Immunotherapy for treating PCa!

Us Too Warriors,

This website provides future Hope for treatment for PCa.

Best
Peter

Abstract:

Immunotherapy has shown promising therapeutic effects in hematological malignancies and certain solid tumors and has emerged as a critical and highly potential treatment modality for cancer. However, prostate cancer falls under the category of immune-resistant cold tumors, for which immunotherapy exhibits limited efficacy in patients with solid tumors. Thus, it is important to gain a deeper understanding of the tumor microenvironment in prostate cancer to facilitate immune system activation and overcome immune suppression to advance immunotherapy for prostate cancer. In this review, we discuss the immunosuppressive microenvironment of prostate cancer, which is characterized by the presence of few tumor-infiltrating lymphocytes, abundant immunosuppressive cells, low immunogenicity, and a noninflammatory phenotype, which significantly influences the efficacy of immunotherapy for prostate cancer. Immunotherapy is mainly achieved by activating the host immune system and overcoming immunosuppression. In this regard, we summarize the therapeutic advances in immune checkpoint blockade, immunogenic cell death, reversal of the immunosuppressive tumor microenvironment, tumor vaccines, immune adjuvants, chimeric antigen receptor T-cell therapy, and overcoming penetration barriers in prostate cancer, with the aim of providing novel research insights and approaches to enhance the effectiveness of immunotherapy for prostate cancer.

Link 1 : "Website"
or Go To
https://www.sciencedirect.com/science/article/abs/pii/S0304383524005500
*
A NEW ALTERNATIVE TREATMENT FOR PCa = SOUR HONEY??

Us Too Warriors,

I just heard of this treatment for PCa = Sour Honey which seems to originate from a special Bee from Brazil. I have not used it or know much about it, but I am giving a web page for you to see if you are interested.

Best
Peter

Benefits of Sour Honey for Prostate Cancer Treatment

Sour honey, also known as “miel de agave,” has emerged as a promising alternative treatment for prostate cancer. Prostate cancer is the second most common cancer in men worldwide, and traditional treatment options such as surgery, radiation therapy, and chemotherapy can have significant side effects.

1. Antioxidant Properties
Sour honey is rich in antioxidants, which can help protect cells from damage caused by free radicals. Free radicals are unstable molecules that can lead to DNA damage and contribute to the development of cancer. By neutralizing free radicals, antioxidants in sour honey may help prevent prostate cancer progression.

2. Anti-inflammatory Effects
Chronic inflammation has been linked to prostate cancer development and progression. Sour honey contains anti-inflammatory compounds that can help reduce inflammation and potentially inhibit the growth of prostate cancer cells. This anti-inflammatory effect may be beneficial in slowing down the spread of the cancer.

3. Immune-Boosting Properties
Studies have shown that sour honey can enhance the immune system’s response to cancer cells. By boosting immune function, sour honey may help the body more effectively identify and destroy cancerous cells in the prostate. This immune-enhancing effect can complement conventional cancer treatments and improve outcomes.

According to a recent study published in the Journal of Cancer Research and Therapeutics, prostate cancer patients who incorporated sour honey into their treatment regimen experienced a significant decrease in tumor size and PSA levels. The study also reported fewer side effects compared to standard treatments like chemotherapy.

Furthermore, a survey conducted among prostate cancer patients in Mexico revealed that 80% of participants who used sour honey as part of their treatment reported improvements in symptoms and overall quality of life. These findings highlight the potential of sour honey as a natural and effective therapy for prostate cancer.

Link 1 : "Sour honey, also known as black Salve honey,"
or Go To
https://www.cancersupportcommunitybenjamincenter.org/the-potential-of-sour-honey-as-an-alternative-cancer-treatment-benefits-effectiveness-and-cost-comparison.html

SAINT CHARLES -- Oxymel N°1 - Sauerhonig classic Bio -- Honey Vinegar Drink

This Oxymel - Sour Honey classic comes from a tried and tested pharmacist's recipe of organic blossom honey from the Weinviertel and naturally cloudy organic apple vinegar. The drink is stirred in a gentle process and never heated. Thus all ingredients are preserved.

We carefully select all suppliers and pay attention to the regionality of the ingredients. The honey is an organic blossom honey from the Weinviertel region from the master beekeeping company Honig & Co. We found the naturally cloudy and non-pasteurised apple vinegar at the Demeter farm Voelkel. In this way we ensure that only the highest quality ingredients are used in our sour honey.

Link 2 : "Saint Charles Apothecary - Oxymel - Sour honey"
or Go To
https://saint-charles.eu/en/products/oxymel-sauerhonig-classic
***
Iron anemia or Iron excess is bad for heart, kidneys, brain, depression- Mental health. A Goldilocks Iron to be right amount !!!

Us Too Warriors,

The right amount of hemoglobin (so you do not have anemia) is for men is 13.5 to16 and for women about12 to14. I learn about this from immunotherapy reaction that caused psoriasis skin inflammation that caused my hemoglobin to drop from above 12 to 9.2 and also caused my C-reactive protein to go from less than one from all anti-inflammatory supplements from less than one to more than 5 which is not Good for the heart. This Made me stop my immunotherapy for Melanoma that seems to have disappeared for 11 metastases (I can start it again if they come back)

I started to take Iron 2 pills (325mg Ferrous sulfate) for my crPCa with Casodex about a month ago for ferroptosis to kill Prostate cancer and My hemoglobin has increased to 11.2 and and my c-reactive protein is now less than one again since stopping the immunotherapy which is excellent. I am now taking 1 1/2 pills of iron for the next month as excess iron is as harmful as too little Iron. One of my brothers has hemochromatosis where you caused too much iron absorption which seems to have damaged his heart valves so he is having valve replacement at UVa hospital this month.

But only very high iron is detrimental to prostate cancer but this probably varies with the stage of the cancer. Also very high iron in the brain, heart and kidneys among these organs is harmful as is low Iron.

My cancer is crPCa which has only a few treatments that usually work only a short time like LU177 and only if you have high PSMa Molecules on your cancer. I don't have any so far from my PSMA scans. For this reason my trial with Ferroptosis (100 gm/d of Casodex plus 2 325 pills of Ferrous Sulfate makes sense and it seems to be working (lower Psa/not doubling every 5 months as it had been doing for the last 4 years.and low hemoglobin suggests I needed more Iron for my heart, brain and kidneys also and fight fatigue from my treatments..) and my Hemoglobin has gone from 9.7 to 11.2 in one month.

Life is Good, have a Blessed Month. We are not having a meeting this month but call (804-387-2151) or or email (pcmoon@vcu.edu) if you have questions.

Best
Peter

Abstract:

An increasing amount of research has recently strengthened the case for the existence of iron dysmetabolism in prostate cancer. It is characterized with a wide array of differential expression of iron-related proteins compared to normal cells. These proteins control iron entry, cellular iron distribution but also iron exit from prostate cells. Iron dysmetabolism is not an exclusive feature of prostate cancer cells, but it is observed in other cells of the tumor microenvironment. Disrupting the machinery that secures iron for prostate cancer cells can retard tumor growth and its invasive potential. This review unveils the current understanding of the ways that prostate cancer cells secure iron in the tumor milieu and how can we exploit this knowledge for therapeutic purposes.

Link 1 : "Iron Anemia"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277552/#s4title
*
Paper - Website discussing the Concerns and process involved using Ferroptosis to treat cancers

Us Too Warriors,

My Personal concern is that excess IRON can weaken brain function but I have had anemia from my Psoriasis inflammation and my many blood draws so my iron supplements are needed to function well so far they have reduced my fatigue by reducing my Anemia as measure by my red blood cell level. I plan to do blood draws to check my iron levels in blood and anemia. When My Anemia disappears I will reduce/stop my iron supplement and try to use the iron in my body to continue Ferroptosis with just Casodex.

Best
Peter

Abstract:

Ferroptosis is a type of regulated cell death characterized by iron accumulation and uncontrolled lipid peroxidation, leading to plasma membrane rupture and intracellular content release. Originally investigated as a targeted therapy for cancer cells carrying oncogenic RAS mutations, ferroptosis induction now exhibits potential to complement chemotherapy, immunotherapy, and radiotherapy in various cancer types. However, it can lead to side effects, including immune cell death, bone marrow impairment, liver and kidney damage, cachexia (severe weight loss and muscle wasting), and secondary tumorigenesis. In this review, we discuss the advantages and offer an overview of the diverse range of documented side effects. Furthermore, we examine the underlying mechanisms and explore potential strategies for side effect mitigation.

Link 1 : "Ferroptosis"
or Go To
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-024-01999-9#Tab1
*
Benefit of Reishi Mushrooms for fighting High cholesterol in fighting PCa and Heart disease

Us Too Warriors,

Cholesterol forms artery plaque in heart disease and the cell membrane as needed for fast growing cancer cells. Reducing Cholesterol is beneficial for heart health and slowing cancer. I recently added (last 3 months) Reishi mushroom supplement from Swanson as I thought it would slow my cancer. I just found online that it is the basis of the long life of Okanowians by reducing their heart problems in reducing cholesterol plaque.

I recently reported to you that myLDL had dropped from 130 to 76 which I attributed to my vitamin C infusion but in fact I had not had any infusions for about 4 months when this level of Cholesterol was measured but I had been taking Reishi Mushrooms pills1 to1.5 grams/d. Read below to find out more.

Best
Peter

Link 1 : "Reishi Mushrooms"
or Go To
https://www.webmd.com/diet/health-benefits-reishi-mushrooms

A new treatment for CRPCa - Ferroptosis

Us Too Warriors,

I have include the website so you can research this method of killing prostate cancer which I have been using for two months with Some Success- combining 130 mg from Iron sulfate and 100mg of Casodex a day, which so far has stopped my PSA from doubling every five months if these results hold thru August I Will Report on it at the September meeting. See the websites from the google search below to let you become familiar with the research in this treatment.

Check this website for more to Protect you and Yours

Best
Peter

Abstract
The incidence of prostate cancer is the second most among male cancers after lung cancer. Prostate cancer develops rapidly and is inclined to metastasize, and castration-resistant prostate cancer (CRPC) can be formed in the later stage, which brings great challenges to the prognosis and treatment. At present, the main treatment of prostate cancer is generally divided into four methods: surgery, chemotherapy, radiotherapy and endocrine therapy. However, the efficacy of these methods fails to satisfy the demands of patient prognosis. Ferroptosis is a newly discovered iron-dependent process, characterized by lipid peroxidation. Ferroptosis is associated with many diseases, especially tumor growth. In recent years, inhibiting tumor growth and overcoming tumor drug resistance by inducing ferroptosis has become a hot research topic. Previous studies have shown that induction of ferroptosis may be a new treatment for prostate cancer. We review the research progress of ferroptosis in prostate cancer in order to provide highly effective therapies for patients with prostate cancer.

Link 1 : "Ferroptosis and Prostate cancer"
or Go To
https://www.nature.com/articles/s41391-022-00583-w
*
Lowering LDL lipids can lower PSA to some degree too

Us Too Warriors,

Lower LDL can lower PSA. Statins can lower LDL to fight Prostate cancer. From Google see how LDL affects PSA as Follows.

"Yes, lowering LDL cholesterol levels can lower prostate-specific antigen (PSA) levels:
Dietary interventions

A study of 291 men found that PSA levels decreased by 1.9% for every 10% reduction in LDL cholesterol levels after dietary interventions. These interventions included high-fiber, low-glycemic index, low-glycemic load, cholesterol-lowering, LGI, and LGL."

MY high dose Infusion Of Vitamin C reduced my Level of LDL by 30% so it reduced my PSA by about 5.7%.

Best
Peter
*
UnExpected Benefit of High dose Vitamin C Infusion in Lowering LDL and fighting Cancers

Us Too Warriors,

My LDL lipids usually 110-120 over the last 39 years but today they came back at 76. I think this is thanks to my high dose -100 gm Vitamin C infusions that I have been using to fight my cancers.

"Yes, high-dose vitamin C infusions can lower LDL cholesterol levels. Vitamin C, also known as ascorbic acid, helps the liver convert cholesterol into bile acids, which reduces LDL levels. Vitamin C also has antioxidant properties that can prevent damage to LDL cholesterol, which can build up in arteries and cause heart attack or stroke"

Sometimes even a Blind Squirrel finds a NUT or two.

"Based on the structural and signaling roles of cholesterol, which are necessary for immune cell activity, high concentrations of cholesterol and its metabolites not only trigger malignant cell activities but also impede immune responses against cancer cells".

Best
Peter
*
Drugs to Avoid as we age due to side effects Website

Us Too Warriors,

The drug I am most Concerned about is Benadryl which can bring on Akzheiner's.

Check this website for more to Protect you and Yours

Best
Peter

Link 1 : "Drugs to Avoid"
or Go To
https://www.goodrx.com/health-topic/senior-health/risky-medications#older-antihistamines
*
To Keep Inflammation low/slow cancer, you need to follow a low inflammation diet with low Histamine food

Us Too Warriors,

With my psoriasis from melanoma Immunotherapy, I Have to be extra careful -for example-last week in an effort to get extra vegetables in my diet I cooked a bag of frozen Lima beans , a favorite of mine without realizing it is high in histamines so I had a bad week with psoriasis breakouts on myskin. Today this showed up as a big drop in my Red blood Cell count from 11.2 (already anemic) to 9.7 Much worse. Also my white cell count fell as the Macrophages tied up my iron - not good because you need iron to make red blood cells. Food diet info follows to help keep inflammation from histamines down so your cancer will not grow as fast.

Best
Peter

Link 1 : "Inflammation"
or Go To
https://www.histaminintoleranz.ch/downloads/SIGHI-Leaflet_HistamineEliminationDiet.pdf
*
All Health Oils = Olive. Avocado and Coconut Oils Website

Us Too Warriors,

In the oil/fat wars, there are some clear winners and losers. First the losers–processed vegetable seed oils including corn oil, soybean oil, cottonseed oil, sunflower oil, and canola oil are extremely dangerous to our health; can cause inflammatory diseases, an increase in harmful free radicals, damage DNA and even increase the risk of certain types of cancer. High omega 6 vegetable seed oils lose BIGTIME.

Best
Peter

Link 1 : "Health Oils"
or Go To
https://thenutritionwatchdog.com/olive-oil-vs-avocado-oil-vs-coconut-oil/

The Use of Dutasteride/Proscar for 24 years has keeped my cancer cells androgen receptors from Amplification (multiplying)

Us Too Warriors,

I finally understand why my self directed treat with dutasteride & proscar has worked so well over these 30 years. See the attached website to learn more.. I knew that These drugs blocked the formation of Dihydrotestosterone which grows PCa 10 Times faster than testosterone but now I know DHT amplifies the receptor on the cancer cells. By using these drugs I have been able to keep my testosterone High because there are fewer receptors on the cancer cells for it to attach to.

Thank GOD for Miracles. This has allowed my cancer not to grow even with High testosterone.

See Website below for more details. I finally understand why my self directed treat with dutasteride & proscar has worked so well over these 30 years. See the attached website to learn more. I knew that These drugs blocked the formation of Dihydrotestosterone which grows PCa 10 Times faster than testosterone but now I know DHT amplifies the receptor on the cancer cells. By using these drugs I have been able to keep my testosterone High because there are fewer receptors on the cancer cells for it to attach to.

Best
Peter

Link 1 : "Dutasteride/Proscar"
or Go To
https://www.vumedi.com/video/aua-2024-insights-manipulating-the-androgen-axis-new-agents-in-mhspc-and-crpc/?token=21d43540-df32-46eb-82e3-9ccd01a57a59&utm_source=USERS%20Urology%20ALL_133255&utm_medium=Video&utm_campaign=%5BUSERSUROALL%5DAUA%202024%20Insights%3A%20%22Manipulating%20the%20Androgen%20Axis%20-%20New%20Agents%20in%20mHSPC%20and%20CRPC%22&utm_content=AUA%202024%20Insights%3A%20%22Manipulating%20the%20Androgen%20Axis%20-%20New%20Agents%20in%20mHSPC%20and%20CRPC%22&utm_term=Ad

Histamine as a cause for PCa growth. Quercetin is a supplement to block this PCa grow & My Heart Afib & Immuno Psoriasis itch !

Us Too Warriors,

See the Article below.

Best
Peter

Abstract

Psoriasis is caused by a complex interplay among the immune system, genetic background, autoantigens, and environmental factors. Recent studies have demonstrated that patients with psoriasis have a significantly higher serum homocysteine (Hcy) level and a higher prevalence of hyperhomocysteinaemia (HHcy). Insufficiency of folic acid and vitamin B12 can be a cause of HHcy in psoriasis. Hcy may promote the immuno-inflammatory process in the pathogenesis of psoriasis by activating Th1 and Th17 cells and neutrophils, while suppressing regulatory T cells. Moreover, Hcy can drive the immuno-inflammatory process by enhancing the production of the pro-inflammatory cytokines in related to psoriasis. Hcy can induce nuclear factor kappa B activation, which is critical in the immunopathogenesis of psoriasis. There may be a link between the oxidative stress state in psoriasis and the effect of HHcy. Hydrogen sulfide (H2S) may play a protective role in the pathogenesis of psoriasis and the deficiency of H2S in psoriasis may be caused by HHcy. As the role of Hcy in the pathogenesis of psoriasis is most likely established, Hcy can be a potential therapeutic target for the treatment of psoriasis. Systemic folinate calcium, a folic acid derivative, and topical vitamin B12 have found to be effective in treating psoriasis.

Link 1 : "Histamine"
or Go To
https://pubmed.ncbi.nlm.nih.gov/31670376/

Lower T4 indicates Hypothyroidism which may produce a slower growing PCa

Us Too Warriors,

Abnormally low levels of free thyroxine (T4), a hormone produced by the thyroid gland, may indicate hypothyroidism, or an underactive thyroid:
Adults: 0.8–1.8 nanograms per deciliter (ng/dL) of blood

T4, Free, Direct My Measured value was 0.8ng/dL so I have Hypothyroidism which may have slowed my Prostate cancer

View trends
Normal range: 0.7 - 1.5 ng/dL Measured 5/29/2024

Best
Peter

*
From May 6 th to May 22nd My recent supplements that have lowered my PSa from 3.5 to 2.3

Us Too Warriors,

I take 2 to 3 pills a day of these pills to fight PCa.

Check them out for your Fight With My Best wishes.

Peter

1. two 65 mg Iron sulfate and two 50 mg pills of Casodex (Prescription) I believe these are the most affected agents.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023567/

2. Reishi Mushroom extract 500mg from Swanson Inc.Reishi Mushroom and prostate cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755215/

3. Advanced Black Seed 4X- extract 250 mg and 50 mg of thymoquinone by Triquetra Nigella Sativa and Prostate cancer
https://f1000research.com/articles/13-229#:~:text=According%20to%20the%20findings%20of,metastasis%20in%20PCa%20experimental%20models.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587125/#:~:text=Recent%20studies%20reported%20that%20thymoquinone,and%20metastasis%2C%20is%20still%20unknown.

4. Dihydromyricetin 700 mg by Sexy Beautiful Me
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317349/#:~:text=DHM%20effectively%20suppresses%20the%20proliferation,(CXCR4)%20%5B60%5D.

5. Hesperidin 500 mg by Swanson
https://pubmed.ncbi.nlm.nih.gov/36139707/#:~:text=Disrupting%20Ca2%2B%20Homeostasis-,Hesperidin%20Suppresses%20the%20Proliferation%20of%20Prostate%20Cancer%20Cells%20by%20Inducing,%3B11(9)%3A1633. .

6. Rapamycin 2mg/day prescription which I was taking as an anti aging pill for the mind which I now find works to fight Prostate cancer when used with Casodex - https://theinterstellarplan.com/2021/03/rapamycin-mtor-inhibition/

Best
Peter
*
Prostate cancer treatment Affects the Heart often so you need to check with Cardiologist

Us Too Warriors,

Chances are at some point you’ve thought about whether or not to see a cardiologist. With statistics like heart disease is the leading cause of death for men and women in the United States, it has surely crossed your mind.

General cardiologists are practitioners that focus on the heart. If you are at risk for heart disease, a routine check-up with this specialized physician can help you to be on top of your heart health.

Best
Peter

Link 1 : "Twelve Reasons to See a Cardiologist"
or Go To
https://www.pennmedicine.org/updates/blogs/heart-and-vascular-blog/2020/august/12-reasons-to-see-a-cardiologist#:~:text=12%20Reasons%20to%20Schedule%20a%20Visit%20With%20a,You%27ve%20been%20diagnosed%20with%20diabetes.%20...%20More%20items

I have just received Dihydromyricetin (DHM) as part of fight of PCa

Us Too Warriors,

I have not started taking it yet. I am already using 4 specific supplements to slow my PCa that have seemed to have slowed my cancer from doubling every 5 months to doubling every three years if the present results hold for a while.
But I am holding DHM for a backup which my wife thought was important.

Best
Peter

DHM effectively suppresses the proliferation of prostate cancer cells by reducing angiogenesis and prevents in vitro migration and invasion of PC-3 human prostate cancer cell lines by downregulating the expression of C-X-C motif chemokine receptor 4 (CXCR4) [60].Jul 18, 2022

Link 1 : "DHM"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317349/#:~:text=DHM%20effectively%20suppresses%20the%20proliferation,(CXCR4)%20%5B60%5D.
*
Drugs to Avoid to prevent the progression Of Alzheimer's as We age

Us Too Warriors,

You and your family need to see this website on how you can avoid the drugs that damage brain function.

Best
Peter

Link 1 : "Drugs to Avoid to prevent the progression Of Alzheimer's"
or Go To
https://www.youtube.com/watch?v=k-3BY-naQ0M
*
(Thyroid function) It appear even with normal TSH, T3 and T4 readings the thyroid may not work properly

Us Too Warriors,

Poor Thyroid function can affect PCa growth rate.I think I may have a thyroid problem as I feel cold if my room temperature is below 80 to 85 degrees (maybe caused by mybrain surgery for melanoma mets???) How do you feel when your thyroid is out of whack==> Depression and Brain Fog Combined with the feelings of fatigue, you can feel sluggish, experience mood swings, and see signs of depression. Over half of people with hypothyroidism experience depression.

I have a benign nodule on my right thyroid gland, I am going to get it checked out. I think you may need a special endocrinologist because normal values may still indicate malfunction of the thyroid gland???

Denis Wilson, md: Low Body Temperature as an Indicator for Poor Expression of Thyroid Hormone

Best
Peter

Link 1 : "Thyroid Hormone"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566469/#
*
Actinium 225 a new radio Isotope to Treat PCa for PSMa presenting cancers

Us Too Warriors,

Actinium 225 PSMA radioligand therapy for prostate cancer. The investigators concluded, “Actinium-225 PSMA radioligand therapy shows a substantial antitumor effect in metastatic castration-resistant prostate cancer and represents a viable therapy option in patients treated with previous lines of approved agents. Xerostomia is a common side-effect. Feb 2, 2024

Best
Peter

Link 1 : "Actinium 225"
or Go To
https://ascopost.com/news/february-2024/actinium-225-psma-radioligand-therapy-for-prostate-cancer/#:~:text=The%20investigators%20concluded%2C%20%E2%80%9CActinium%2D,is%20a%20common%20side%2Deffect.
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Blog on use of ADT can show up as loss of Brain Function initially as Forgetfulness -Menthol and spearmint Tea may help

Us Too Warriors,

Question from Blog ==>Are there any ways to help with the side effect of forgetfulness / mild cognitive impairment while on ADT? My Dad (stage 4 PC) started on ADT 2 only months ago, but there have been a few moments of mild cognitive impairment since starting - forgetting shopping list, trying to return stuff at the wrong store…he’s usually very on the ball. Of course the anxiety of a new and unexpected diagnosis also doesn’t help I’m sure. But anything that can help with brain fog/forgetfulness on ADT? Or is that just a SE he lives with?

Best
Peter

More Info:
What does menthol do for the brain? How brain health and smell are connected. Menthol lowers inflammation in the part of the brain associated with memory. “There appears to be an immunomodulatory effect of menthol in the prefrontal cortex, an area related to memory input, and one that is dysfunctional in the Alzheimer's patient,” explained Dr. Osborn.May 19, 2023

Google search on Spearmint tea==> "Spearmint tea has been used as a traditional remedy to improve brain function. The antioxidants and polyphenols in spearmint leaves may help elevate brain activity, and may also help the brain secrete neurotransmitters like serotonin and dopamine that enhance mood. Human studies have shown that spearmint may help boost working memory, focus, attention, and concentration. One study found that spearmint improved cognitive function in 142 women and men aged 50–70 who took 900 mg of spearmint extract daily. " I have used a "Focus Tea "from LEF.org which is Pricey at a dollar bag/cup It made me more alert but there are similar products on amazon at about 30cents a bag. As I have one APOE4 Alzheimer's Gene, brain function is a concern of mine.

Link 1 : "Purchase"
or Go To
https://www.bulkapothecary.com/raw-ingredients/other-ingredients-and-chemicals/menthol-crystals-usp/
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Benefits of Reishi mushroom extract for health and fighting cancers

Us Too Warriors,

Please check out this website to see if you want to add this mushroom to your armentarian to battle cancer.

Best
Peter

Abstract:
Medicinal Mushrooms are rich sources of pharmacologically active compounds. One of the mushrooms commonly used in traditional Chinese medicine is Ganoderma lucidum (Leyss. Ex Fr.) Karst. In Asian countries it is treated as a nutraceutical, whose regular consumption provides vitality and improves health. Ganoderma lucidum is an important source of biologically active compounds. The pharmacologically active fraction of polysaccharides has antioxidant, immunomodulatory, antineurodegenerative and antidiabetic activities. In this review, we summarize the activity of Ganoderma lucidum polysaccharides (GLP).

Link 1 : "Medicinal Mushrooms"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400705/
*
WEBSITE VIDEO for men with anxiety or depression from PCa

Us Too Warriors,

"A lot of men would rather not talk to their doctors about it. They don't wanna look as if there's something wrong with them psychologically or psychiatrically like they're crazy."

Far too often, some men hesitate to bring up emotional struggles, fearing judgment or being perceived as weak. But the truth is, these emotions are incredibly common among prostate cancer patients, and there is no shame in seeking help.

Watch this entire session, Strategies for Coping with Anxiety and Depression, by Dr. Andrew Roth at bit.ly/rothstrategies.

Best
Peter

Link 1 : "Anxiety or Depression"
or Go To
https://www.inspire.com/groups/zero-prostate-cancer/discussion/strategies-for-coping-with-anxiety-and-depression/?utm_source=referral&utm_medium=web&utm_content=copied_link
*
A New Treatment with Hope for Men with crPCa being Tested in a Clinical Trial

Us Too Warriors,

A new hope for men with metastatic prostate cancer

Best
Peter

Link 1 : "New Treatment"
or Go To
https://hospitalnews.com/a-new-hope-for-men-with-metastatic-prostate-cancer/
*
A paper that Analyzes How Complicated it is to determine Lu 177 is going to Help or Harm in the treatment of PCa !!!

Us Too Warriors,

Until I read this paper and its discussion of PCa heterogeneity, I only knew LU 177 did not help if you did not have PSMA Molecules on your cancer.
Both my brother, Don, and I seem not to have PSMA. I now think it can be Harmful treatment after reading the paper site copied below.

Jerry Deans seemed to get much worse and die after his second treatment with Lu 177. Please read the paper at site to follow to be forewarned.

Best
Peter

Link 1 : "Lu 177"
or Go To
https://www.prostatecancer.news/2019/12/why-lutetium-177-psma-treatment.html
*
Developments coming in PSMA Imaging Discussed at website below

Us Too Warriors,

Dr. Schuster highlights the FDA approval of imaging agent flotufolastat F 18 in prostate cancer.

Best
Peter

Link 1 : "PSMA"
or Go To
https://www.urologytimes.com/view/dr-schuster-highlights-the-fda-approval-of-imaging-agent-flotufolastat-f-18-in-prostate-cancer?utm_source=www.urologytimes.com&utm_medium=relatedContent
*
Lp(a) is a lipid molecule in the blood (like LDL) that increase PCa and Heart Problems

Us Too Warriors,

This problem is more likely if you have a big stomach =overweight and diabetic. The use of a baby aspirin and CoQ10 supplement of 200 mg/day can reduce this problem. Also CoQ10 can help prevent muscle wasting from advanced cancer consuming all your calories to grow itself. Best Peter
From Google:
The analysis showed that genetic variants that predict higher blood levels of lipoprotein A were associated with a higher overall risk of prostate cancer, and also a higher risk of advanced or early-age-onset prostate cancer.

Best
Peter
*
Magnesium Salts supplement Has Many forms and each has potential benefits
for Afib, Sugar Control, Brain, heart, Fatigue, Sleep, Depression etc

Us Too Warriors,

I take Magnesium Threonate for brain issues and Taurate for Afib besides other 300 uses in
our bodies. I take two or three 100mg pills per day towards the 400 mg daily requirement.

Best
Peter

Link 1 : "10 Types of Magnesium (and What to Use Each For)"
or Go To
https://www.healthline.com/nutrition/magnesium-types#:~:text=10%20Types%20of%20Magnesium%20%28and%20What%20to%20Use,...%208%208.%20Magnesium%20sulfate%20...%20More%20items
**
Lower magnesium in your Diet leads to more Advanced Prostate cancer

Need 400 mg/day helps lower bad actor calcium from Dairy

Us Too Warriors,

I try to supplement with 200 to 300 mg/d of Magnesium Citrate,.Malate or Taurate and avoid
Dairy to fight My PCa. See some googled comments below from searching "Magnesium and Prostate Cancer".

Best
Peter

Link 1 : "Magnesium"
or Go To
https://www.newsmax.com/health/dr-crandall/magnesium-heartbeat-vitamin-d/2024/02/07/id/1152713/

Lowering Cholesterol with a statin drug and diet may lower PSA

Us Too Warriors,

Lowering Cholesterol with a statin drug and diet may lower PSA - I am 10 years on a Statin.

Best
Peter

Abstract:
Prostate cancer (PCa) is the most common cancer in men in developed countries. Epidemiological studies have associated high blood-cholesterol levels with an increased risk of PCa, whilst cholesterol-lowering drugs (statins) reduce the risk of advanced PCa. Furthermore, normal prostate epithelial cells have an abnormally high cholesterol content, with cholesterol levels increasing further during progression to PCa. In this review, we explore why and how this occurs. Concurrent to this observation, intense efforts have been expended in cardiovascular research to better understand the regulators of cholesterol homeostasis. Here, we apply this knowledge to elucidate the molecular mechanisms driving the accumulation of cholesterol in PCa. For instance, recent evidence from our group and others shows that major signalling players in prostate growth and differentiation, such as androgens and Akt, modulate the key transcriptional regulators of cholesterol homeostasis to enhance cholesterol levels. This includes adjusting central carbon metabolism to sustain greater lipid synthesis. Perturbations in cholesterol homeostasis appear to be maintained even when PCa approaches the advanced, 'castration-resistant' state. Overall, this provides a link between cholesterol accumulation and PCa cell growth. Given there is currently no cure for castration-resistant PCa, could cholesterol metabolism be a novel target for PCa therapy? Overall, this review presents a picture that cholesterol metabolism is important for PCa development: growth-promoting factors stimulate cholesterol accumulation, which in turn presents a possible target for chemotherapy. Consequently, we recommend future investigations, both to better elucidate the mechanisms driving this accumulation and applying it in novel chemotherapeutic strategies.

Link 1 : "Lowering Cholesterol"
or Go To
https://pubmed.ncbi.nlm.nih.gov/23357067/

Orgovyx and its side effects on the heart's electrical system Blog

Us Too Warriors,

From The Blog Boonster:
I've been taking Orgovyx for over two years with few side effects. But I have been experiencing episodes of dizziness and light-headedness over the last few months.
My cardiologist has diagnosed bradycardia (a slow heartbeat that can cause such episodes). I will need a pacemaker.
I know a side effect of Orgovyx is Long QT Syndrome, which, like bradycardia, affects the heart's electrical system.
I wonder if bradycardia needs to be added to the list of Orgovyx's serious side effects?
--Boon

In the journals :
Magnetic resonance imaging (MRI) has long been considered dangerous for people who have electronic heart devices like pacemakers and defibrillators implanted in their bodies. Now, a study published online Aug. 14, 2017, by the Journal of Clinical Electrophysiology suggests the scans are safe for most people with these devices. Until recently, most devices were not FDA-approved for MRI. They had been considered risky because it was feared that the high-strength magnetic fields used for the scanning could disrupt a pacemaker's or defibrillator's circuits. Yet, when researchers reviewed 212 MRI examinations involving 178 patients with these non approved devices, they did not find a single problem with how they functioned. The researchers concluded that MRI is safe for someone with a device implanted after 2000, as long as the device is checked before and after the procedure and its pacing function is monitored during the scan. In the last seven years, the FDA has approved newer and more expensive devices that are designed to be safe for MRI; these are labeled "MRI conditional." However, the researchers noted that you don't need to replace your older device with an MRI-compatible model before getting a scan.

Best
Peter

RESVERATROL and CANCER - New research, 4 papers reviewed and potential use
in treating COVID-19 mRNA Vaccine Induced Turbo Cancer (p53, chemo resistance)

Us Too Warriors,

RESVERATROL and CANCER - New research, 4 papers reviewed and potential use in treating COVID-19 mRNA Vaccine Induced Turbo Cancer (p53, chemo resistance)
DR. WILLIAM MAKIS MD -APR 25 - ∙ - PREVIEW

Best
Peter

Papers Reviewed:
(2020 April, Berretta et al) - Resveratrol in Cancer Patients: From Bench to Bedside
(2022, April, Almatroodi) - Potential Therapeutic Targets of Resveratrol, a Plant Polyphenol, and Its Role in the Therapy of Various Types of Cancer
(2022 Nov, Jang et al) - Mechanism of Resveratrol-Induced Programmed Cell Death and New Drug Discovery against Cancer: A Review
(2023 Nov, Kursvietiene et al) - Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions

Link 1 : "RESVERATROL and CANCER"
or Go To
https://makismd.substack.com/p/resveratrol-and-cancer-new-research?utm_source=post-email-title&publication_id=1385328&post_id=143978779&utm_campaign=email-post-title&isFreemail=true&r=lm59g&triedRedirect=true&utm_medium=email

Variation in ADT (Lupron) use Continuous Vs Intermittent and patients weight are reported in this paper

Us Too Warriors,

Variation in ADT (Lupron) use Continuous Vs Intermittent and patients weight are reported in this paper

Best
Peter

Abstract:
As a clinical strategy, intermittent androgen deprivation therapy (IADT) has the potential to minimize adverse events associated with continuous androgen deprivation therapy while providing comparable efficacy for patients with advanced prostate cancer. Because most studies supporting IADT to date have been somewhat small and underpowered, additional large, randomized, controlled trials are needed before this strategy becomes the standard of care. However, the potential advantages of IADT, which include improved quality of life, the theoretical possibility of delaying hormone resistance, and possible reduction in expenses to the patient and health care payers, suggest it is a strategy worth further exploration.

Link 1 : "Lupron"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859136/
*
How to improve your walking to Fight PCa

Us Too Warriors,

How Long Should I Take to Walk a Mile?
Story by Alyssa Sparacino • 13h • 5 min read

Best
Peter

Link 1 : "Walking"
or Go To
https://www.msn.com/en-us/health/fitness/how-long-should-i-take-to-walk-a-mile/ar-BB1iVjrt
*
Life extension magazine report on maintaining Muscle mass

Us Too Warriors,

Preventing Sarcopenia:

While most doctors warn against the age-related loss of bone mass, few pay attention to the equally debilitating loss of muscle mass commonly seen in older people. Here are steps that you can take today to preserve healthy muscle mass throughout your lifetime.

Best
Peter

Link 1 : "Sarcopenia"
or Go To
https://www.lifeextension.com/magazine/2007/1/report_muscle
*
A new treatment for Breast cancer bone metastasis may apply to PCa bone Mets and other cancers

Us Too Warriors,

This looks Promising=>Israeli researchers reach bone metastasis breakthrough for breast cancer patients.

Best
Peter

Link 1 : "Metastasis"
or Go To
https://www.jpost.com/science/article-795177

Website that discusses when you can be treated by urologist or should be treated by an Oncologist for PCa

Us Too Warriors,

Basically both will normally only provide you with standard of Care unless they are more open to treat you as an individual and listen to what's important to you as an individual. Basically the urologist will treat your cancer as long as it is only in the lymph nodes and the Oncologist treats cancers when they metastasize beyond the lymph nodes. There is no hard and fast rule about which doctor you see. If you have a knowledgeable urologist that you can communicate well with and he has good experience and support you may well stay with him (her) longer. I switched to an oncologist immediately after prostate surgery because of the bad proste report that suggested my Gleason went to 8 from 3+4 and 35% more cancer was found in my prostate. The surgery gave me 5 years before it failed. This gave me time to figure out what to do to slow the cancer - I have had 6 oncologists over the last 30 years mostly because they retired or moved on.

Best
Peter

Link 1 : "Treatment by Oncologis or Urologist?"
or Go To
https://www.vumedi.com/video/managing-advanced-prostate-cancer-pts-in-urology-clinics-and-when-to-refer-to-medical-oncologists/?token=aa7a9e80-fe87-4200-8474-d86243f13d3a&utm_source=USERS%20Urology%20ALL_129250&utm_medium=Video&utm_campaign=Managing%20Advanced%20Prostate%20Cancer%20Pts%20in%20Urology%20Clinics%20and%20When%20to%20Refer%20to%20Medical%20Oncologists&utm_content=Managing%20Advanced%20Prostate%20Cancer%20Pts%20in%20Urology%20Clinics%20and%20When%20to%20Refer%20to%20Medical%20Oncologists&utm_term=Advanced%20Stage%20Prostate%20Cancer&link_data=eyJidWxrX21haWxfYWN0aW9uIjoiYyIsInJlY2lwaWVudF9pZCI6MjA3OTgyNjg3OSwibWFpbF9pZCI6MTI5MjUwfQ%3A1rrb3s%3AVAij_AIqRZDf_1IWkjyICnG3YtmwEEKZa4SX44YMspA&mail_id=129250

Cancer - Age and Cancer have a way of breaking down our muscle strength - below are some ways to help maintain Strength besides exercise

Us Too Warriors,

Read the following to keep your muscles strong with age.

Best
Peter

Link 1 : "Compound found in coffee may improve muscle health and function during aging"
or Go To
https://www.medicalnewstoday.com/articles/compound-coffee-fenugreek-may-improve-muscle-health-function-aging

Vitamins B12 and D at low levels is associated with Muscle loss for people with type2 diabetes

Us Too Warriors,

Read the following to keep your muscles strong with age.

Best
Peter

Link 1 : "Muscle loss"
or Go To
https://www.nutraingredients-asia.com/Article/2021/09/01/Lower-vitamin-B-and-D-intake-linked-to-muscle-loss-in-older-people-with-type-2-diabetes#
*************************************
Bee Propolis to treat PCa with ARV7 mutation

Us Too Warriors,

ARV7 mutation in PCa usually occurs after many years of treatment and is the cause of failure for some men on standard care.

In the last 6 months I added this to my supplements even though I Haven't tested for arv7 mutation. The abstract that follows describes its use.

Best
Peter

Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT

Abstract:

Androgen receptor (AR) splice variant 7 (AR-V7) is capable to enter nucleus and activate downstream signaling without ligand. AR-V7 assists the tumor growth, cancer metastasis, cancer stemness, and the evolvement of therapy-resistant prostate cancer (PCa). We discovered that caffeic acid phenethyl ester (CAPE) can repress the expression and downstream signaling of AR-V7 in PCa cells. CAPE blocked the gene transcription, nuclear localization, and protein abundance of AR-V7. CAPE inhibited the expression of U2AF65, SF2 and hnRNPF, which were splicing factors for AR-V7 intron. Additionally, CAPE decreased protein stability of AR-V7 and enhanced the proteosome-degradation of AR-V7. We observed that CDK1 and AKT regulated the expression and stability of AR-V7 via phosphorylation of Ser81 and Ser213, respectively. CAPE decreased the expression of CDK1 and AKT. Overexpression of CDK1 restored the abundance of AR-V7 in CAPE-treated PCa cells. Overexpression of AR-V7, AKT or CDK1 rescued the proliferation of PCa cells under CAPE treatment. Intraperitoneal injection of 10 mg/kg CAPE retarded the growth of 22Rv1 xenografts in nude mice and suppressed the protein levels of AR-V7, CDK1 and AKT in 22Rv1 xenografts. Our study provided the rationale of applying CAPE for inhibition of AR-V7 in prostate tumors.

Link 1 : "Bee Propolis"
or Go To
https://www.nature.com/articles/s41417-024-00753-z
***************************************************************************
Website below for 25% discount on Many blood tests thru Life Extension until June

Us Too Warriors,

Website below for 25% discount on Many blood tests thru Life Extension until June

Best
Peter

Link 1 : "Blood Tests"
or Go To
https://www.lifeextension.com/sales/lab-tests?gad_source=1&gclid=CjwKCAjwte-vBhBFEiwAQSv_xRZ53p6r-SDVoEB5rU--NRl08MveFhNFpc1K03UhiScTVBn9Vn7ZfRoC1hQQAvD_BwE
*

The Video scheduled below for 17/18 of May may help those among us dealing with depression that the curve balls we have been pitched in life.
Exercise often helps as well as reaching out and interacting with others. Medications can help also as will probably be discussed in this video. Best Peter

Link 2 : "Depression"
or Go To
https://clinicaloptions.com/events/psychiatry-summit-2024/psychiatry-summit-2024/10518-11227?mkt_tok=NDIzLU1OUC03MjEAAAGR_IhuXtch02nsKlTzLGmv3GwgEq5-XA7ux846BVg9j3JpjMd5aKy_Yjvx8AoJu5qBNSod0p0gmbbA1QVzI51jYjPCmZ6cW-lTDx-tBjjlngsZ
***********************************************************************
Suggested Checklist for men on ADT

Us Too Warriors,

Suggested Checklist for men on ADT. As you may know I am not a fan of ADT but for some it will work for awhile and these suggestions may help.
*
Androgen Deprivation Therapy (ADT) Checklist for Men

(Revised Aug 15, 2022 Fort Collins UsToo Group and modified by RVa Us Too Group March 18th ,2024)

Use this checklist along with your healthcare provider to understand how ADT affects men and to develop plans to mitigate the side effects of ADT. The most common first line ADT treatments that are given by injections include Leuprolide (trade names: EligardTM, Lupron®, ViadurTM ) and Degarelix (trade name: Firmagon® ). On December 18, 2020, the Food and Drug Administration approved the first oral (pill) gonadotropin-releasing hormone (GnRH) receptor antagonist, relugolix, (ORGOVYX TM, Myovant Sciences, Inc.) for advanced prostate cancer. There are other 2nd line hormonal therapies that might be prescribed for high risk/very high risk and metastatic initial treatments and recurrent treatments such as enzalutamide (Xtandi TM), apalutamide (Erleada TM), darolutamide (Nubeqa TM) as well as abiraterone (Zytiga TM).

Best
Peter

Link 1 : "Androgen Deprivation Therapy Checklist"
or Go To
http://rvaprostatecancersupport.org/PDF/3 18 24 Androgen Deprivation Therapy.pdf
***********************************
Video explaining the difference in the treatments for Advance/Metastatic PCa by Oncologist VS Urologists

Us Too Warriors,

It is helpful if you know the difference between these types of Doctors to get the treatment you may need. I switched from my Urologist surgeon 5 years after my surgery when I had BioChemical recurrence of the cancer. But with My research/scientific background I have always told my doctors the treatment I wanted as I am still doing today for both PCa and melanoma. So far so good- All my scans for 10 Melanoma mets are gone and the PSMA scan can not find my PCa at PSa 1.5.

I am a happy camper for now.

Not only is it important to know the difference between these doctors, it is very important to find a Doctor you can work with that listens to what is important to you. For certain treatments you may have to travel out of the area if you can afford to for a special /Unique treatments only available at certain cancer centers - I have gone to John hopkins for consultation and I was able to get a local cancer center to start a new treatment - Just FDA approved Immunotherapy for my Melanoma called Opdualag.
In this regard quality of life is important to me and has been a guiding principle in my treatment selections.
See the website below for the video

Best
Peter

Differences Between Urologists and Medical Oncologists in the Management of Advanced and Metastatic Prostate Cancer
By NORTHWESTERN MEDICINE ONCOLOGY AND HEMATOLOGY FEATURING WILLIAM CATALONA

Link 1 : "Treatments"
or Go To
https://www.vumedi.com/video/differences-between-urologists-and-medical-oncologists-in-the-management-of-advanced-and-metastatic/?token=e88b125c-20d1-4aa4-8161-757e04509701&utm_source=USERS%20Urology%20ALL_128005&utm_medium=Video&utm_campaign=Differences%20Between%20Urologists%20and%20Medical%20Oncologists%20in%20the%20Management%20of%20Advanced%20and%20Metastatic%20Prostate%20Cancer&utm_content=Differences%20Between%20Urologists%20and%20Medical%20Oncologists%20in%20the%20Management%20of%20Advanced%20and%20Metastatic%20Prostate%20Cancer&utm_term=Advanced%20Stage%20Prostate%20Cancer&link_data=eyJidWxrX21haWxfYWN0aW9uIjoiYyIsInJlY2lwaWVudF9pZCI6MjA1NjU0NTI3OCwibWFpbF9pZCI6MTI4MDA1fQ%3A1rkiMR%3APRut9eWTLS3IYbN9QWCke4_oEYKIxZkEQ565UqiKAtg&mail_id=128005
*
Paper website for BAT =Bipolar Androgen therapy works for 30 to 40% of men

Us Too Warriors,

For this treatment to work you need to be castration resistant from being on ADT (lupron). While on ADT you can develop many more Cancer cell receptors for testosterone which are needed to kill the cancer when you are high levels of Testosterone, BAT treatment. I do not expect it will work for me as I have kept a high testosterone for my thirty years of treatment so I will not have a high level of androgen receptors on my cancer cells. I have stayed away from Lupron to keep quality of life (muscles ,brain, heart and energy).

See the website below for the paper.

Best
Peter

Abstract:
Bipolar androgen therapy (BAT) is a new treatment concept for men whose prostate cancer has become resistant to standard hormone‐blocking therapy. Over the past decade, we have performed a series of clinical studies testing BAT in asymptomatic men with castration‐resistant prostate cancer. The key findings from these clinical studies are that BAT (a) can be safely administered to asymptomatic patients with metastatic castrate‐resistant prostate cancer; (b) does not produce symptomatic disease progression; (c) produces sustained prostate‐specific antigen and objective responses in 30%–40% of patients; and (d) can resensitize and prolong response to subsequent antiandrogen therapy. The concept of BAT has generated significant interest from men with prostate cancer, their families, and their physicians. Here we provide a “Patient's Guide” that answers questions about BAT in a form that is accessible to patients, their families, and physicians. Our goal is to provide information to help patients make the most informed decisions they can regarding their prostate cancer treatment.

Link 1 : "Link 1"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313844/
*
Monotherapy use of Nubequa Clinic trial reports 99.6% reduction in PSA in all 100% of the men being treated

Us Too Warriors,

One of our members is using this treatment and in the first month he had a reduction of his PSA from the 200 range to 30.

So he is having a good early response with a good chance that he may match the good results of the clinic trial below in time.

This treatment is not FDA approved yet nor is the Monotherapy with Casodex (No Lupron shots or Orgovyx pills so you keep your testosterone and therefore energy and mind and heart) which I have used for 6 years with no problem as it is cheap compared to Nubequa so nobody seems to care???

To get a Doctor to agree to give you Nubequa you may need to get Orgovyx pills also to block testosterone but do not take the pills and that will then be monotherapy, which is what I hope to do if my off label drugs do not work as well as I expect.

Best
Peter

Link 1 : "Link 1"
or Go To
https://www.onclive.com/view/dr-tombal-on-darolutamide-monotherapy-in-newly-diagnosed-mhspc

Inhibitors of Protein Kinases that inhibit PCa growth

Us Too Warriors,

The following table and paper website lists Inhibitors of Protein Kinases you can purchase online to slow your Prostate cancer.

I have and am using many of the agents like Super Bio Curumin from LEF.org and along with Apigenin from Swanson Plus Berberine, ECCG(G.tea), resveratrol, quercetin and fisetin etc etc. for many years. You will find Curcumin and Emodin in the list below which I was taking up to 2009 when I saw Dr. Snuffy Myers.

He asked what I had been taking to control my cancer - I responded with Curcumin within 6 Months he was recommending it to his patients. You can see it blocks all of the protein Kinase which I did not know at the time. I also mention Emodin, also called Fo-ti, which he did not like which from his research at NIH he considered a poison.

I doubled it - as I expected it to poison the cancer. I am still using it 14 years later. I am taking 4 pills a day of Super biocurcumin now. Until about 2019 I took 10 pills a day of supper Biocurcumin. The website for the paper that has the table is below - Use Link 1.

Best
Peter

Flavonols:

Quercetin has been found in apples, berries, red onions, cherries, broccoli, coriander, etc. [43]. Beside TKs, it has been shown to inhibit the serine/threonine kinases, AKT, mTOR, MAPK, ERK1/2, JNK, etc. This indicates that this compound inhibits members of major pro-survival signalling pathways as shown in Figure 1. A linked search for the number of citations found for quercetin, protein kinases and cancer amounted to 344.

Kaempferol. Common foods that contain kaempferol include apples, grapes, tomatoes, green tea, potatoes, onions and broccoli, just to name a few fruits and vegetables. Kaempferol has been shown to inhibit angiogenesis by targeting VEGF receptor-2 and down-regulating the PI3K/AKT, MEK and ERK pathways [44]. Moreover, kaempferol inhibits invasion and migration of renal cancer cells through the downregulation of AKT and FAK pathways [45] and it increases apoptosis in human cervical cancer HeLa cells via the PI3K/AKT and hTERT pathways [46].

Fisetin has been found in strawberries, apples, persimmons, onions and cucumbers. It has shown anticancer activity on mammary carcinoma cells via regulation of the PI3K/AKT/mTOR pathway [47]. It inhibits laryngeal carcinoma through regulation of AKT/NF-κB/mTOR and ERK1/2 signalling cascades [48] Moreover, it has been shown that fisetin induces apoptosis in human non-small cell l

Link 1 : "Link 1"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469162/

NEW TIL Treatment ="Tumor Infiltrating Lymphocytes" Treats Multiple cancers including PCa and Melanoma!!! at advanced Stages

Us Too Warriors,

This new TIL treatment that has been perfected in the last few years looks to be a Game Changer for patients with advanced disease. It is only available after other treatments are exhausted at Clinics of excellence like MD Anderson in Texas etc.

It requires a piece of cancer tissue extracted from the patient that can be used to get the Lymphocytes from and grow them up (multiply them by the millions in the LAb) and injected back into the cancer in the body to kill the cancer (TIL are part of the immune system fighting the cancer by this process you grow enough ammunition outside of the body to kill the the cancer when these million of cells are injected back into the cancer nass..) It will be expensive but likely covered by insurance.

New Hope for All.

Best
Peter

What is a tumor-infiltrating lymphocyte?(MD Anderson Center - Link 1)
Lymphocytes, or white blood cells, are an important part of the immune system that helps the body fight off infections or eliminate diseased cells. Lymphocytes, made up of T cells and B cells, are constantly patrolling the body to identify cells that shouldn’t be present, including cancer.

As cancers grow, lymphocytes recognize these cells as abnormal and penetrate into the tumor. These are the tumor-infiltrating lymphocytes, or TILs.

Once in the tumor, the TILs begin working to kill cancer cells. Sometimes, they’re prevented from doing that by brakes in the immune system or signals from the tumor that weaken the immune response. Immune checkpoint inhibitors were developed to block some of those brakes and unleash the immune cells to attack cancer.

We also can use the TILs themselves, with some improvements, as a form of cell therapy.

Link 1 : "Tumor Infiltrating Lymphocytes"
or Go To
https://www.mdanderson.org/cancerwise/what-is-tumor-infiltrating-lymphocyte-til-therapy--6-things-to-know.h00-159460056.html

If you have prostate cancer You are more prone to melanoma and
if you have melanoma you are more prone to prostate cancer

Us Too Warriors,

(See abstract to follow) If you have prostate cancer you should consider getting more skin checks by a Dermatologist to catch melanoma before it progresses!!!! I had about 6 Biopsies for melanoma over the last 5 years all caught at early stages but I had biopsies which were not followed by"Mohs" surgery to prove no cancer cells remain by microscope examination of the margins to be sure no cancer remains. Starting this year a surgeon has been hired to check each case with microscopically Mohs surgery, I recommend you have a Dermatologist that uses Moh Surgery in their practice.

Best
Peter

Abstract:(Link 1)
Melanoma and prostate cancer are the fifth and first most common cancers in men within the United States, respectively. The association between the two cancers lies in the mutual androgen-dependence. However, the relationship between prostate cancer history and melanoma development remains to be further elucidated. We aim to determine the odds of history of prostate cancer among men with melanoma as compared to time-frame, clinic, and provider-matched controls without melanoma within a single academic surgical center. We present a case-control study comparing men treated for melanoma and non-melanoma cancer by a single provider between 2010 and 2014 within an academic dermatologic surgical center. Overall, there were nine cases of prostate cancer among the melanoma group and two cases amongst the controls—a statistically significant difference in both uni- and multivariable analyses (p = 0.057 [95% CI 1, 23.5], p = 0.042 [95% CI 1.1, 129], respectively). Body mass index, alcohol use, and skin type II were significant risk factors for melanoma (p = 0.011 [95% CI 1, 1.3], 0.005 [95% CI 1.4, 7], 0.025 [95% CI 1.1, 3.3], respectively). There were more immunosuppressed controls (p = 0.002); however, the melanoma patients had a significantly longer duration of immunosuppression (11.6 vs. 1.9 years, p < 0.001 [95% CI 0.03, 0.5]). Melanoma screenings for men should include questions on prostate cancer history. Prostate cancer patients may benefit from more frequent and comprehensive melanoma screening.

Link 1 : "Link 1"
or Go To
https://pubmed.ncbi.nlm.nih.gov/25884238/
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Image from paper showing many of the ways that supplements interferes with growth of Cancer in Cells

Us Too Warriors,

Open the website below to see many of the supplements I have bought online to slow my cancer that I have used over the last 30 years.

The first website below is the image of cancer pathways and supplements that act on them in the cell and the second website is the paper that Image comes from for more details.

Best
Peter

Abstract:(Link 2)
The advantage of natural compounds is their lower number of side-effects when compared to most synthetic substances. Therefore, over the past several decades, the interest in naturally occurring compounds is increasing in the search for new potent drugs. Natural compounds are playing an important role as a starting point when developing new selective compounds against different diseases. Protein kinases play a huge role in several diseases, like cancers, neurodegenerative diseases, microbial infections, or inflammations. In this review, we give a comprehensive view of natural compounds, which are/were the parent compounds in the development of more potent substances using computational analysis and SAR studies.

Link 1 : "Link 1"
or Go To
https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=7698043_biomolecules-10-01546-g001.jpg

Link 1 : "Link 2"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698043/

Off label drug that makes Docetaxel CHemo work better, longer
and at lower dose that can be bought online without Prescription not expensive.

Us Too Warriors,

This sounds too good to be true!!! Drug name is Dicyclomine. To Find an Online purchase website use "Link 1"

I do not know the dose but I am sending the paper describing its use below. If in the future you expect to start Docetaxel treatment??? you can use this information. See "Link 2"

Best
Peter

Link 1 : "Link 1"
or Go To
https://www.google.com/search?q=dicyclomine+buy+online&rlz=1C1CHBF_enUS819US819&oq=dicyclomine+purchase++online&gs_lcrp=EgZjaHJvbWUqCAgBEAAYFhgeMgYIABBFGDkyCAgBEAAYFhgeMggIAhAAGBYYHjINCAMQABiGAxiABBiKBTINCAQQABiGAxiABBiKBTINCAUQABiGAxiABBiKBTINCAYQABiGAxiABBiKBdIBCjIxNTcxajBqMTWoAgCwAgA&sourceid=chrome&ie=UTF-8

Link 2 : "Link 2"
or Go To
https://www.news-medical.net/news/20240122/Receptor-protein-found-to-be-a-key-player-in-prostate-cancer-cells-drug-resistance.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=prostate_cancer_newsletter_1_february_2024

The advantages Nubeqa of over Casodex, Xtandi and Erleada

Us Too Warriors,

Warriors,
There are fewer side effects from Nubeqa as it does not cross the Blood/Brain Barrier and if you can get it as a monotherapy without Lupron or Orygvix as I am looking into it causes less Heart problems and Fatigue!!!

Check this website for info.

Best
Peter

Link 1 : "Advantages"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367726/

Zero cancer-Information on the Use of Off label drugs and the right to try Drugs not FDA Approved

Us Too Warriors,

Warriors,
There are laws that allow Doctors to prescribe drugs for treatments that have not been FDA approved. But it is not easy to get Doctors to do so. I have been able to find online doctors/pharmacies to provide the off Label Drugs I use for a small charge.

Virginia is a "Right to Try State" that allows Doctors to provide treatment to patients that have exhausted FDA approved treatments.

Check these websites below for more information

Best
Peter

Link 1 : "Link 1"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538391/#:~:text=Off%2Dlabel%20drug%20use%20involves%20prescribing%20medications%20for%20an%20indication,medicine%2C%20OLDU%20has%20become%20common.

Link 2 : "Link 2"
or Go To
https://www.fda.gov/media/133864/download#:~:text=What%20is%20Right%20to%20Try%3F&text=Right%20to%20Try%20is%20one,and%20Drug%20Administration%20(FDA).
**********************************
Hyaluronic Acid =HA is a type of sugar in the extraCellular matrix surrounding the cancer cells that can feed them to grow

Us Too Warriors,

Warriors,
"Hyaluronic acid, or HA, is a known presence in pancreatic tumors, but a new study from researchers at the University of Michigan Health Rogel Cancer Center shows that hyaluronic acid also acts as food to the cancercells.Jan 27, 2022 "
The statement above was copied from Google online!

I found it because I was searching for how my Off Label Drug=

"4-methylumbelliferone" worked to fight prostate and melanoma.

IT WORKS BY REDUCING HA(ie. sugar) IN THE EXTRACELLULAR MATRIX SO IT DOESN'T FEED CANCER GROWTH!!! It reduces 4 growth processes in all cancers. It is not surprising it reduced my PSA by 40% in 3 days.

Best
Peter
(Website for info on slowing PCa growth by blocking HA follows)

Link 1 : "HA"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848908/
*****************************************************************************
I tripled my dose of two of my Off labeled drugs for three days before my recent PSA test and had 40% reduction in my PSA 3.6 to 2.5 in a month

Us Too Warriors,

Warriors,
The two drugs that I added to my usual mix were Micro Niclosamide heated to 200c, vibrate in olive oil and blended with 9.5 pH water taken 3 times a day which I had taken once a day (but not recently with my melanoma diagnosis). The other drug that I added was 4-Methylumbelliferone (p) which again I took by dissolving its powder in green & black tea heated to dissolve the powder plus adding my usual ginseng powder packet (the drug made the tea taste bitter which is a good sign as bitter herbs are found to be good for treating PCa.) I had not taken this off label drug though I had bought it because being treated with melanoma got in the way.

I drank three cups a day. I expect to get Rapamyacin in the mail this weekend from online and I will continue these drugs three times everyday for the next month to see how it may continue to lower My PSA.
(As a Scientist I am doing what I was trained to do: Research theory and Plan experiments to test the theory to develop new treatment Info)

I should have a new PSA test to report at the March Meeting.

Best
Peter
*****
Off label list of Drugs to fight PCa that I use which I will discuss at our meeting on March 21, 2024

Us Too Warriors,

Warriors,
I am going to discuss drugs that I am taking to slow my cancer so in case you find them helpful you can see about adding them to your armouraterian.
I have found them from my many years of research in PCa.
To check them for yourself the best way is to Google
``Drug Name and Prostate Cancer" to find out how it works. {(p) after the drug means it is a prescrription} Best Peter

1. Doxycycline (p)
2. Finasteride (p)
3. Dutasteride
4. Calcitriol (active Vitamin D by prescription) (p)
5. Metformin (p)
6.Naltrexone LDN=4.5 mg (p)
7. Melatonin
8. Vitamin K2 -MK7
9. 4-Methylumbelliferone (p)
10. Rapamycin (just getting soon) (p)
11, Piracetam with L-Carnitine supplement added (p)
12. Nano Made Niclosamide 8 grams -made by dissolving in 200C olive oil in Microwave about 3+ minutes, then Shakened in Ultrasonic and blended in 9.5 pH water
13. Multiple supplements & Drugs -Bio Curcumin, Berberine, Apigenin, Vitamin D3-8000 IU, Pravastatin(p), Resveratrol, Myracetin (Plus many more)
I am trying to obtain
14. Erinacrine (p) , Nubeqa(p)
15. 0. Casodex (p)

Best
Peter
*
Pluvicto was tested in a clinic trial without having Docetaxel or ADT or may be only limit ADT first

Us Too Warriors,

If you are older(age?) and/or have health issues that make taking Docetaxel difficult your Doctor can get an exception for you to get it like my Brother (87 next week). I think if you are in your late 70's or 80's you should be able to get it or if you have disabilities from the cancer. You may have to hunt to find the Doctor to do it?

(IT appears this trial has been completed. If it has GOOD results reported I hope soon it will make getting Pluvicto easier.)

Best
Peter

Link 1 : "Pluvicto"
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/150499765/psma-addition-trial-can-give-access-to-pluvicto-for-denovo-or-mhspc
*****
Good news for treatment for one of our Members

Us Too Warriors,

A new treatment has lowered the PSA from 70 to 3 of a Member with CrPCa in the first month with Nubequa monotherapy and radiation to his back bone metastasis.

Nubequa monotherapy is only available in Australia. The way to get it as monotherapy in USA is to get Nubequa (blocks the androgen receptor on the PCa cells and Orgivixic (which stops production of testosterone) from your oncologist and not take the Orgivixic pills. Our member's oncologist was so pleased with the results of the treatment that he did not care that our member had not taken the Orgivixic pills and suggested he did not need to take the texcetera chemotherapy that was planned. Our member plans to see how this treatment continues before doing anything else. This treatment of Nubequa monotherapy is one I have been planning to try to get as soon as my melanoma was under control which seems to be approaching.

Best
Peter
*
Pluvicto was tested in a clinic trial without having Docetaxel or ADT or may be only limit ADT first

Us Too Warriors,

If you are older(age?) and/or have health issues that make taking Docetaxel difficult your Doctor can get an exception for you to get it like my Brother (87 next week). I think if you are in your late 70's or 80's you should be able to get it or if you have disabilities from the cancer. You may have to hunt to find the Doctor to do it?

(IT appears this trial has been completed. If it has GOOD results reported I hope soon it will make getting Pluvicto easier.)

Best
Peter

Link 1 : "Pluvicto"
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/150499765/psma-addition-trial-can-give-access-to-pluvicto-for-denovo-or-mhspc
************************************
Treatment Intensification in Advanced Prostate Cancer" on VuMedi

Us Too Warriors,

The forwarded email below from Dr Moul of Duke University and others that follow deal with recent developments of treatment intensification for men with Advanced PCa.

You can cycle thru the videos to find ones that may help you decide about treatments that fit your situation.
Best
Peter

Dear Peter Moon,
I would like to share with you a video I’ve posted on VuMedi:

"Treatment Intensification in Advanced Prostate Cancer".

Best regards,

Judd Moul, MD
Duke Cancer Institute, Duke University, Durham, NC

Link 1 : "Treatment Intensification in Advanced Prostate Cancer"
or Go To
https://www.vumedi.com/video/treatment-intensification-in-advanced-prostate-cancer/?token=6d7e2b1e-debe-45ce-9853-20114effdb68&utm_source=USERS%20Urology%20ALL_125055&utm_medium=Video&utm_campaign=Treatment%20Intensification%20in%20Advanced%20Prostate%20Cancer&utm_content=Treatment%20Intensification%20in%20Advanced%20Prostate%20Cancer&utm_term=Advanced%20Stage%20Prostate%20Cancer&link_data=eyJidWxrX21haWxfYWN0aW9uIjoiYyIsInJlY2lwaWVudF9pZCI6MTk5ODkyNDA0MiwibWFpbF9pZCI6MTI1MDU1fQ%3A1rSyPQ%3A6KFENkp1ZrifPELO6mtvqIu_IuA5h-WoUPrbkz5M7dU&mail_id=125055

Zero cancer- Short video (7 minutes) from MD Anderson showing how PCa treatment & health conditions affect survival - website

Us Too Warriors,

The website to follow shows how ADT may shorten survival if you are prone to Metabolic conditions, heart disease, bone loss & mental problems among other conditions. You will need to take extra effort to ward off these afflictions if you are on ADT.
(It explains why I have avoided ADT as much as possible to Maintain my testosterone for going on 30 years).

Best
Peter

Link 1 : "Short Video"
or Go To
https://www.vumedi.com/video/challenging-the-prevailing-therapeutic-dogma-for-prostate-cancer-the-case-for-an-overlap-syndrome/?token=8fb4d095-d19e-4b19-85c4-c3ddd1905199&utm_source=USERS%20Urology%20ALL_125053&utm_medium=Video&utm_campaign=Challenging%20the%20Prevailing%20Therapeutic%20Dogma%20for%20Prostate%20Cancer%3A%20The%20Case%20for%20an%20%22Overlap%20Syndrome%22&utm_content=Challenging%20the%20Prevailing%20Therapeutic%20Dogma%20for%20Prostate%20Cancer%3A%20The%20Case%20for%20an%20%22Overlap%20Syndrome%22&utm_term=Advanced%20Stage%20Prostate%20Cancer&link_data=eyJidWxrX21haWxfYWN0aW9uIjoiYyIsInJlY2lwaWVudF9pZCI6MTk5Njc4MjQyMiwibWFpbF9pZCI6MTI1MDUzfQ%3A1rSFe0%3A4I4GRM35cd-8MoEkcg-j71aAK3vEVZT4NxCInt0jvfc&mail_id=125053

My Brother after 30 years with Prostate cancer has just started treatment with Pluvicto (a Radioactive agent) for PSMa presenting cancer

Us Too Warriors,

My brother, at 88 yrs recently was approved for Pluvicto because his doctor fought for him to get it because of his age and condition suggesting he would not do well on Chemotherapy. (if it had not been approved he would have given him a low dose of chemo to show it did not work to qualify him for Pluvicto without causing harm.)

This is the kind of Doctor you want on your side.

Below is the Pluvicto website's requirement that my brother had to meet to get the Pluvicto Drug. (Which his doctor had to argue for)

Best
Peter

Link 1 : "Pluvicto"
or Go To
http://rvaprostatecancersupport.org/PDF/1 23 24 Pluvicto.pdf

Blog discussing flare in PSA and concerning Blood Counts after first Chemotherapy (Docetaxel ?)

Us Too Warriors,

This blog is the first evidence I have read of a flare in PSA etc after chemo which this blog suggests may indicate failure of treatment and the need to switch to another treatment ASAP

Best
Peter

Link 1 : "Flare in PSA"
or Go To
http://rvaprostatecancersupport.org/PDF/1 21 24 Blog from.pdf
*
New imaging agent "Posluma" for low levels of PSA believed better than Pylarify imaging. FDA approved last summer. Is it available in our area??

Us Too Warriors,

New imaging agent "Posluma" for low levels of PSA believed better than Pylarify imaging. FDA approved last summer. Is it available in our area??

Best
Peter

Link 1 : "Posluma"
or Go To
http://rvaprostatecancersupport.org/PDF/1 21 24 POSLUMA.pdf
*
Protecting Mitochondria in diseases and cancer to fight fatigue, loss of health /function, aging and cancer.

Us Too Warriors,

Many of you know I have taken as many 300 supplement pills when I was younger over the last 30 years. I am down to 150 pills/day that alternate on days to get my 300 pills in. They have helped me up to now fight prostate cancer for 30 years and 10 of my 11 melanoma mets this year. The jury is still out on the one met in my left lung but the increase seen today is hoped to be radiation scarring so we are holding course with immunotherapy until the next scan in two months.

The website site that follows shows how I have defeated fatigue in my cancer treatments with my supplements to foxtrot 1 mile on warm days plus walk a 1/2 mile.

Best
Peter

Link 1 : "Protecting Mitochondria"
or Go To
https://www.youtube.com/watch?v=uIjzl5FQlK8
*
How to Reduce Chemo Side Effects

Us Too Warriors,

Jerry Deans used this therapy with an ice cap, booties, gloves and ice chips in the mouth to prevent hair loss, mouth/saliva issues, stomach and neuropathy problems.

Best
Peter

Link 1 : "How to Reduce Chemo Side Effects"
or Go To
http://rvaprostatecancersupport.org/PDF/1 14 24 How to Reduce Chemo Side Effects.pdf

Melatonin for treating PCa and Vitamin K2 for Blocking Excess Bleeding

Us Too Warriors,

As shown in the paper below Melatonin has many possible ways of fighting PCa.

I have been using 40 mg of Melatonin every night for years . However, I also take vitamin K2 everyday at a medium dose of 300 mcg and at a mega dose (45,000mcg from Life extension) if I have bleeding occasionally from hemorrhoids. Melatonin at this 10 to 40 mg/nite and above is a blood thinner which along with all my blood draws can cause anemia and fatigue which make fighting cancer Hard. When I do not bleed much during the month my red blood levels are about 12.8 and are barely anemic at a below 13.0 and below the anemia level when I bled a lot during the month my red blood levels would drop to 11.0 or less.

It is hard to function, fight cancer when you are anemic.

Best
Peter

Abstract.

Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and experimental studies have documented that melatonin could inhibit different types of cancer in vitro and in vivo. Results showed the involvement of melatonin in different anticancer mechanisms including apoptosis induction, cell proliferation inhibition, reduction in tumor growth and metastases, reduction in the side effects associated with chemotherapy and radiotherapy, decreasing drug resistance in cancer therapy, and augmentation of the therapeutic effects of conventional anticancer therapies. Clinical trials revealed that melatonin is an effective adjuvant drug to all conventional therapies. This review summarized melatonin biosynthesis, availability from natural sources, metabolism, bioavailability, anticancer mechanisms of melatonin, its use in clinical trials, and pharmaceutical formulation. Studies discussed in this review will provide a solid foundation for researchers and physicians to design and develop new therapies to treat and prevent cancer using melatonin.

Link 1 : "Melatonin"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123278/

I am looking forward to A better New year, but feel fortunate to survivied 2023

Us Too Warriors,

I have survived 12+ falls at home from brain melanoma, Brain surgery, Hospital rehab and 4 SBRT treatment rounds to 9 melanoma mets, Bone biopsies, Many MRI, CT scans PSMA pet scans, EDG scans, Monthly blood draws, monthly ImmunoTherapy infusions, 50 Vitamin C(125 gms) Infusions April to Dec.

Finally, On Christmas eve I came down with Covid 19 which I am almost over with thanks to 5 daily rounds Of Paxlovid Plus 2000 mg Vitamin C, 100mg Zinc and 5000 IU of Vitamin D3 every 4 hours.

I was fox trotting a mile a day on good weather days by December before covid and walking a 1/2 mile - I hope to get back to that by the end of January.

I hope your new year is better?

My Friends stay well and fight the Good fight. There will be No Us Too meeting this Jan 2024.

Call me at 804-387-2151 if I can help answer questions?

Best
Peter

Radiation prevalence for different stages of PCa ( Early stage SBRT )
<7 treatments, intermediate stage 8 to 29 treatments, advanced 30 or more>

Us Too Warriors,

Dr. Cuttino at Dr. Hospital Forest on Skipwith road can provide these treatments who spoke at our group recently and has treated 9 of my melanoma metastases recently with good results using between 1 and 5 shots of radiation depending on how well the tissue could tolerate radiation.

Best
Peter

Abstract.

Importance Randomized clinical trials have demonstrated the noninferiority of shorter radiotherapy (RT) courses (termed hypofractionation) compared with longer RT courses in patients with localized prostate cancer. Although shorter courses are associated with cost-effectiveness, convenience, and expanded RT access, their adoption remains variable.

Objective To identify the current practice patterns of external beam RT for prostate cancer in the US.

Design, Setting, and Participants This cohort study obtained data from the National Cancer Database, which collects hospital registry data from more than 1500 accredited US facilities on approximately 72% of US patients with cancer. Patients were included in the sample if they had localized prostate adenocarcinoma that was diagnosed between 2004 and 2020 and underwent external beam RT with curative intent. Analyses were conducted between February and March 2023.

Link 1 : "Radiation"
or Go To
https://jamanetwork.com/journals/jamaoncology/fullarticle/2810124?guestAccessKey=d77e152f-751c-46b5-905c-8e998198f628&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamaoncology&utm_content=etoc&utm_term=122223&utm_adv=000004163876

Zero cancer- Paper on Natural Herbs to Inhibit LSD1 causing Mutation
of P53 & thus protect of GENOME from Advanced Prostate Cancer

Us Too Warriors,

I recently sent you a paper showing that the U. of Michigan had developed a drug to Inhibit LSD1 that they are testing in a phase 1 clinical trial to stop NeuroEndocrine Prostate cancer which probably took Jerry Deans Life because he had a mutated P53 gene which until now has been untreatable with Standard of Care.

It may take 10 or more years before the drug U.of M. is FDA approved if ever?? Therefore I look for herbs to treat with that you will find in the next paragraph some which I found out I was already using.

The paper attached discusses the structure of herbal products that may inhibit LSD1 and protect men with NeuroEndocrine Prostate cancer. Many of these products are available on the internet by googling. Jerry Dean had extensive cancer for over twenty years and I have had it going on for thirty years which makes us more prone to NeuroEndocrine cancers. Fortunately I hope some of the herbs I have taken over the years may have protected me including ==>BioCurcumin, Berberine, Melatonin and Hesperidin among others discussed in the paper to follow. If you have been dealing with advanced cancer for 10 years or more with ADT standard of care especially if it has morphed into mCrPC, you may want to consider this paper carefully - Only about 3% of men have Neuroendocrine cancer when first diagnosed. However 20% of men with long PSA may develop NeuroEndocrine Prostate cancer Best for the holidays, Peter

I think I had talked Jerry into taking Berberine and Biocurcumin for a while but not at the level I was for a long time(years) 8 of 15 pills a day- I am down to 4 a day now as it becomes harder with age to take. But after reading this paper I am going up to 6 per day.

Best
Peter

Abstract.

Natural products generally fall into the biologically relevant chemical space and always possess novel biological activities, thus making them a rich source of lead compounds for new drug discovery. With the recent technological advances, natural product-based drug discovery is now reaching a new era. Natural products have also shown promise in epigenetic drug discovery, some of them have advanced into clinical trials or are presently being used in clinic. The histone lysine specific demethylase 1 (LSD1), an important class of histone demethylases, has fundamental roles in the development of various pathological conditions. Targeting LSD1 has been recognized as a promising therapeutic option for cancer treatment. Notably, some natural products with different chemotypes including protoberberine alkaloids, flavones, polyphenols, and cyclic peptides have shown effectiveness against LSD1. These natural products provide novel scaffolds for developing new LSD1 inhibitors. In this review, we mainly discuss the identification of natural LSD1 inhibitors, analysis of the co-crystal structures of LSD1/natural product complex, antitumor activity and their modes of action. We also briefly discuss the challenges faced in this field. We believe this review will provide a landscape of natural LSD1 inhibitors.

Link 1 : "Natural Herbs"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305746/#:~:text=isolated%206%20flavone%2Dbased%20natural,L)%20and%20reversibly%20inhibited%20LSD1

Moon Brother's Prostate cancer clinical trial Starting January

Us Too Warriors,

My two brothers have PCa. One brother for 5 years on active surveillance psa=3.2 with my help and the other for 31 years after prostatectomy with PSA fluctuating between 20 to 50 on standard & my suggestions until about 4 years when he had to get off Xtandi/ Firmagon because fatigue and memory lapses made it hard to walk etc. My brother on active surveillance is on board so we have N=2 for the trial and my niece Doc daughter of my 31 year old PSA brother is looking at the information I have sent so I hope he will Join the study to make the study with an N=3.

Study will use 4 1/2 mg/d of Low Dose Naltrexone (LDN) and one 300 mg/d pill of R-factor Alpha Lipoic acid (should help) as the treatment to see if it lowers the PSA. My experience is that it has lowered my PSA twice for a month of use or less in the last 6 months when I used it for a total of about 45+% drop.

My PSA on Nov 22,2023 was 1.4 and on June 14, 2023, it was 1.5. But with its usual doubling time over the last 3 years before melanoma I would expect it to be over 3.0. This makes me think that the use of LDH has Cut my PSA in More than 1/2 in those 5 months while only using it less than 2 of the 5months.

I hope to check this out between January and May of next year with my Brothers and myself. I will let you know how it Goes.

All the Best for Safe, and Joy Filled Holiday= Peace Be with You.

Best
Peter

Zero Cancer- a new treatment for Endocrine PCa in Clinical trial

Us Too Warriors,

P53 is the protein called the Guardian of the GENOME. It keeps the cancer from Growing as long as it is not mutated and which can turn the PCa into the super aggressive form known as ENdocrine PCa which does not produce PSA and does not respond to the normal standard of care ADT treatments.

I know that Jerry Dean's P53 protein was mutated so it was no longer protecting him. He fought a gallant fight going to Duke, John Hopkins. New York and Chicago besides local radiation for treatments to give himself more time- I think he added at least two years.

It now appears the University of Michigan research has found a way to reverse the Mutation of P53 giving hope to us that I wish Jerry had. I miss having him as a guiding Light in our Group and Great Friend to All.

P53 understanding and function played a part in Nobel Prize awards because of its importance. The information from U of Michigan research on restoring P53 to Function to fight endocrine PCa cancer Follows below.

Best
Peter

Link 1 : "New Mechanism"
or Go To
https://www.sciencedaily.com/releases/2023/08/230814122244.htm

Limit for PSMA Pet scan detection is above 5mm for Lymph nodes ~Maybe 7mm and
for MRI detection limit is above 11 mm for lymph node

Us Too Warriors,

I recently had a negative PSMA Pet scan when my PSA was 2.0. In checking the literature, I found the paper attached below.

The paper indicates that==>Limit for PSMA Pet scan detection is above 5 mm for Lymph nodes(Maybe 7mm) and for MRI the detection limit is above 11mm for lymph nodes.

If you have several, smaller lymph nodes the detection will be even harder. That makes me think I will have to wait Until my PSA> 4.0 before I get another PSMA Pet and MY PSA just went down 1.5 so I am glad I canceled my PETscan at The end of November - when I had just had one at the Beginning of November.

Pets have radiation so there is a limit on how many you get - 3 before you need to worry about causing more cancers.

Best
Peter

Link 1 : "PET Scan"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689635/

The use of Low Dose Naltrexone as adjunctive treatment to slow cancer

Us Too Warriors,

As I have reported, my PSA dropped 25% last month when for the last 3 1/2 years it has been doubling every 5 months or faster. In trying to see if I had done everything differently, I think it HAPPENED because I had added a low dose opioid inhibitor, called Low dose Naltrexone (LDN) at 4.5 mg/day. LDN=1.5 mg/day to 4.5 mg/day . As best as I can understand LDN acts to decrease opioids in your body so your body produces more because it thinks you are low. These opioids cause your cancer cells to be stuck in early S-phase of cell growth and not to traverse to G phase GROWTH as soon as possible, thereby slowing cancer growth.

On the other hand higher doses cause the cancer to grow. A paper is attached below that describes the effects of Ldn on cancers.

I order Naltrexone online( or by phone) from a website called "Ageless" Phone number = 1-650-503-9990 and paid a charge of about $ 70 for the prescription to the Doctor and I think paid less than $ 110 for the prescription pills good for 270 days!=810pills to the New Jersey pharmacy if you are interested. I have castration resistant PCa which developed on 2 1/2 years of CAsodex monotherapy(6yrs now in spite of not working) =poor man's Androgen receptor blocker which has allowed me to keep my testosterone so do not feel like an old man because I do not get Lupron shots = These shots are bad for heart, mind, muscles and mental function/outlook.

Call if you have questions-1-804- 387-2151 OR NEED TO TALK ABOUT ANY TREATMENT. I have a few more of these adjunctive treatments I use which I will put together for a January meeting of the RVa cancer Meeting.

THERE IS NO DECEMBER MEETING - HAVE A HEALTH HOLIDAY. BEST fOR THE NEW YEAR.

Best
Peter

Link 1 : "Naltrexone"
or Go To
https://link.springer.com/article/10.1007/s12325-020-01591-9
**
FINANCIAL AND LEGAL HELP FOR CANCER PATIENTS WHO CANNOT AFFORD TREATMENT

Us Too Warriors,

Patients who are at the Defined poverty level, making them eligible to receive pro bono services from at least one of the more than 200 skilled and compassionate Cancer LINC volunteer professionals. Whether you’re a patient, family member, friend, caregiver, or medical provider, support is only one click away.

Get Help Today Contact Information Cancer LINC 200 South 3rd Street Richmond, VA 23219 Phone: 804-562-0371 Fax: 804-918-0946 Office Hours M-F: 9:00 am - 5:00 pm

Best
Peter

We serve cancer patients across Central Virginia, including any patient receiving treatment through a Richmond area cancer care group or facility. In our most recent fiscal year, CancerLINC helped 693 patients and their families with 813 legal and financial issues. Approximately 91% of these patients live below the Federally-defined poverty level, making them eligible to receive pro bono services from at least one of the more than 200 skilled and compassionate CancerLINC volunteer professionals.

We are unique. To our knowledge, there is no other organization in the Commonwealth like CancerLINC.

Link 1 : "FINANCIAL AND LEGAL HELP"
or Go To
https://cancerlinc.org/
*
Doxycycline use to block MMP 2 & MMP 9 to Slow PCa
I have used 100 mg/per day to slow Cancer-paper attached

Us Too Warriors,

I know of MMPs and Doxycycline treatment from work in dentistry in trying to stop periodontitis inflammation.

Doxycycline use to block MMP 2 & MMP 9 to Slow PCa - I have used 100 mg/per day to slow Cancer - See paper attached

Warriors I have used a Low dose of Doxycycline to slow my cancer. It is a prescription. I also see in this paper that these same MMPs that increase PCa also affect the heart. This should be a no-brainer to get even your GP to prescribe.
(See the Link Below).

Best
Peter

Link 1 : "Doxycycline"
or Go To
https://www.sinobiological.com/category/ads/mmps-cancer-invasion-and-metastasis?utm_source=edm&utm_medium=email&utm_campaign=mmps-2311
*
The Last words from Dr Snuffy Meyer in Prostapedia Oct 2022 after his death on Immunotherapy is a Gift worth reading

Us Too Warriors,

See the Link Below.

SBRT Radiation to my lung nodule this last month reduced My PSa from 1.9 to 1.5 Thanks to Dr Cuttino

Best
Peter

Prostapedia:

In this issue....

Immunotherapy has an interesting status in prostate cancer treatment research. It has attracted some of the best minds in prostate cancer research and motivated innovative laboratory and clinical research. However, we currently have only one agent FDA-approved for the treatment of prostate cancer, Provenge (Sipuleucel-T). Provenge is a cell-based vaccine that involves harvesting a patient’s immune cells, growing them up in large number and exposing these cells to a fragment of a protein found on prostate cancer cells. These cells are then infused back into the patient. This triggers an immune response to the cancer.

Provenge was approved by the FDA in 2010 for the treatment of patients with metastatic hormone resistant prostate cancer because it improved survival. One factor that has limited the use of Provenge is that patients often experience no shrinkage of cancer metastases nor a drop in the PSA. On the plus side, this vaccine has minimal side effects compared to most cancer Among the various immunotherapeutic approaches discussed in this issue, the immune check point inhibitor, B7-H3, looks promising. In this issue, Dr. Emmanuel Antonarakis covers the current status of agents that target B7-H3, including dramatic results in an early small trial in pre-prostatectomy patients. In addition to its role in protecting cancer cells from the immune system, this protein also appears to foster metastatic spread by stimulation invasion and abiogenesis.

Charles E. Myers, Jr., MD

Link 1 : "Prostapedia"
or Go To
https://online.flippingbook.com/view/940171425/

Paper attached on Bipolar Androgen Treatment= BAT for CrPCa form John Hopkin's researchers a main source for this treatments

Us Too Warriors,

See the Link Below.

Best
Peter

Abstract:

Bipolar androgen therapy (BAT) is a new treatment concept for men whose prostate cancer has become resistant to standard hormone‐blocking therapy. Over the past decade, we have performed a series of clinical studies testing BAT in asymptomatic men with castration‐resistant prostate cancer. The key findings from these clinical studies are that BAT (a) can be safely administered to asymptomatic patients with metastatic castrate‐resistant prostate cancer; (b) does not produce symptomatic disease progression; (c) produces sustained prostate‐specific antigen and objective responses in 30%–40% of patients; and (d) can resensitize and prolong response to subsequent antiandrogen therapy. The concept of BAT has generated significant interest from men with prostate cancer, their families, and their physicians. Here we provide a “Patient's Guide” that answers questions about BAT in a form that is accessible to patients, their families, and physicians. Our goal is to provide information to help patients make the most informed decisions they can regarding their prostate cancer treatment.

Link 1 : "BAT"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313844/

Effect Of Sugar On Immunotherapy

Us Too Warriors,

Does sugar affect Immunotherapy? Using mouse models and data from human patients, the researchers found a direct relationship between the amount of sugar that a tumor consumes and the effectiveness of immunotherapy. The more sugar the tumor consumed, the less effective the immunotherapy.(Feb 17, 2021)

What supplements help immunotherapyVitamin A, beta-carotene, folic acid, vitamin B12, vitamin C, vitamin D, riboflavin, iron, zinc, and selenium may all have immunomodulating functions and could enhance the immune response rates of immunotherapy and even reduce irAEs[89]. They play an important role in reducing oxidative stress in diseases and cancers.Sep 24, 2021
See Paper Below

Best
Peter

Abstract:

Immunotherapy is now commonly prescribed to cancer patients, but autoimmune-related adverse events are considerable. For severe, life-threatening side effects, cessation of therapy seems unavoidable, let alone intensive medical care required for patching up the adverse events. Even without serious adverse events, the response rates are too low and various combinatory regimens have been tried. However, toxicities are also added on, unless the adjuvant agents have remarkably few side effects. Actually, micronutrients are usually taken by a majority of cancer patients as nutritional support or to boost the immune function, let alone hoping to counteract treatment side effects. Recent studies have shown that combinations of micronutrients exert pleiotropic effects in controlling tumor growth and metastasis by modulating the tumor microenvironment, enhancing gut microbiota immune functions, and providing adjunct nutritional support to micronutrient deficient cancer patients. A higher than recommended dietary allowance micronutrient dose is proposed to reduce the toxic free radicals generated as a result of immunotherapy and tumor metabolism. This is not only helpful for managing treatment side effects but also enhancing treatment efficacy. As micronutrient supplementation is also useful to improve patients’ quality of life, prolong survival, and sustain compliance to immunotherapy, further investigations are mandatory.

Link 1 : "Sugar"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479349/#ress%20in%20diseases%20and%20cancers
*
Paper attached on repurposed Drugs to improve Immune system to Fight PCa

Us Too Warriors,

I am presently using Metformin and Zinc to improve my Immune system. Metformin is a prescription used for diabetes to help control sugar. I do not have diabetes but it has no side effects as long as your sugar level does not drop below 70. The zinc supplement stimulates your thyroid gland to produce " "t" immune cells to fight cancer by increasing thymosin α1 (thymosin α1 decrease with age and that is one reasons it is thought more cancer shows up as we age) as discussed in the attached paper - see website below..
See Paper Below

Best
Peter

Abstract:

Cancer remains a significant global health challenge with limited treatment options beyond systemic therapies, such as chemotherapy, radiotherapy, and molecular targeted therapy. Immunotherapy has emerged as a promising therapeutic modality but the efficacy has plateaued, which therefore provides limited benefits to patients with cancer. Identification of more effective approaches to improve patient outcomes and extend survival are urgently needed. Drug repurposing has emerged as an attractive strategy for drug development and has recently garnered considerable interest. This review comprehensively analyses the efficacy of various repurposed drugs, such as transforming growth factor-beta (TGF-β) inhibitors, metformin, receptor activator of nuclear factorκB ligand (RANKL) inhibitors, granulocyte macrophage colony-stimulating factor (GM-CSF), thymosin α1 (Tα1), aspirin, and bisphosphonate, in tumorigenesis with a specific focus on their impact on tumor immunology and immunotherapy. Additionally, we present a concise overview of the current preclinical and clinical studies investigating the potential therapeutic synergies achieved by combining these agents with immune checkpoint inhibitors

Link 1 : "Repurposed Drugs"
or Go To
https://www.cancerbiomed.org/content/cbm/early/2023/11/06/j.issn.2095-3941.2023.0281.full.pdf
*
Anemia from ADT treatment = T-inhibitors and/or AR inhibitors

Us Too Warriors,

If your anemia is too bad the Doctor may give Blood Transfusions. Mine is slightly low on AR= Casodex but because I am not on T-hibitor= Lupron, it is not too low. If your testosterone is low because of your age you may be anemic without these drugs. Anemia may be evidenced by shortness of breath and/or fatigue.
See Paper Below

Best
Peter

Abstract:

Objective. Haemoglobin levels often decline into the anaemic range with androgen deprivation therapy (ADT). We conducted a chart review of patients receiving ADT for metastatic prostate cancer to assess anaemia-related symptoms.

Methods. 135 stage IV prostate cancer cases were reviewed for treatment type; haemoglobin values before and after treatment; and symptoms of anaemia. Mean haemoglobin levels before and after for all treatment forms, for leuprolide alone, and for combination leuprolide/bicalutamide were calculated and evaluated for significant differences. The numbers of patients developing symptoms were recorded and the effects of specific therapies evaluated.

Results. For all ADT treated patients, mean haemoglobin declined by −1.11 g/dL (p < .0001). Leuprolide-alone treated patients had a mean decline of −1.66 g/dL (p < 0.0001). Leuprolide and bicalutamide combination treatment caused a mean decline of −0.78 g/dL (p = 0.0426). 16 of 43 patients had anemia symptoms. Contingency analysis with Fisher's exact test shows patients receiving leuprolide therapy alone versus other forms of ADT were significantly less likely to have symptoms (χ2 = 0.0190).

Conclusions: The present study confirms that ADT results in a significant drop in haemoglobin levels into the anaemic range. A number of patients become symptomatic from this change. Practitioners should monitor haemoglobin levels, and treat symptomatic patients.

Link 1 : "Anemia"
or Go To
https://www.tandfonline.com/doi/full/10.1080/13685530802172438
*
Vitamin K2 paper for health - like keeping excess calcium out of heart blood vessels
which helps with heart health if you are on ADT and w/vitamin D3 for PCa

Us Too Warriors,

Check this out - See below

Best
Peter

Abstract:

Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer (CRC) generally characterized by clinical symptoms, including malabsorption, intestinal dysfunction, injury, and microbiome imbalance, as well as certain secondary intestinal disease complications, continue to be serious public health problems worldwide. The role of vitamin K (Vit K) on intestinal health has drawn growing interest in recent years. In addition to its role in blood coagulation and bone health, several investigations continue to explore the role of Vit K as an emerging novel biological compound with the potential function of improving intestinal health. This study aims to present a thorough review on the bacterial sources, intestinal absorption, uptake of Vit K, and Vit K deficiency in patients with intestinal diseases, with emphasis on the effect of Vit K supplementation on immunity, anti-inflammation, intestinal microbes and its metabolites, antioxidation, and coagulation, and promoting epithelial development. Besides, Vit K-dependent proteins (Vit KDPs) are another crucial mechanism for Vit K to exert a gastroprotection role for their functions of anti-inflammation, immunomodulation, and anti-tumorigenesis.

In summary, published studies preliminarily show that Vit K presents a beneficial effect on intestinal health and may be used as a therapeutic drug to prevent/treat intestinal diseases, but the specific mechanism of Vit K in intestinal health has yet to be elucidated.

Link 1 : "Vitamin K2"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769504/
*
Cancer zero Supplements that increase Dopamine that fight PCa, heart health, Brain, AD. PD, stroke and Depression Etc

Us Too Warriors,

I have copied below supplements that help increase dopamine which is good for fighting cancer, for heart health , brain health(Alzheimer's , Parkinson's and depression).

I take 10 of the 12 supplements listed that may be the reason I am not depressed despite my many reasons to be.
See below

Best
Peter

Link 1 : "Supplements"
or Go To
https://www.healthline.com/nutrition/dopamine-supplements
*
Magnesium has Many health benefits as will be discussed at the meeting including fighting higher Calcium in PCa growth

Us Too Warriors,

Check the paper below showing magnesium benefits in fighting PCa. The normal supplementation for magnesium is about 200 mg to 350mg per day if you have kidney function of Glomerular filtration rate of at least 65 or above. If your kidneys are weaker you need to be sure not to overdo the magnesium as the kidneys need to control the level of magnesium in the blood by filtering it in the kidneys. If the kidneys are weak, extra magnesium is hard on them so no supplement may be possible without more damage to the kidneys.
See below

Best
Peter

Link 1 : "Magnesium"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926493/
*
Standard of Care strategies for treating CrPCa

Us Too Warriors,

I am considered Castration resistant and my Doctor again offered me Enzalutamide even though I had turned him down 3 months before. Again I Told him I Wasn't going there after already avoiding it for 30 years. If you get to this stage in your PCa battle you may not be able to take my independent path. The attached paper may help you make a better choice for you. Duralutamide seems to have better results and few side effects.
See below

Best
Peter

Link 1 : "Standard of Care"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066514/
*
Fisetin -a polyphenol to fight multiple cancers

Us Too Warriors,

This is a supplement you may want to consider in your PCa Fight as it blocks many growth pathways.
See below

Best
Peter

Link 1 : "Fisetin"
or Go To
https://www.lifeextension.com/vitamins-supplements/item02414/bio-fisetin?gad_source=1&gclid=Cj0KCQiAjMKqBhCgARIsAPDgWlxgHUutJTQ4og3qSOrtKXk7OdaMk_YiMUrl03NMpNWGgaLdHukww4caAqLJEALw_wcB
*
Improvements in Radiation treatment of PCa with SBRT

Us Too Warriors,

The following video summed up The benefits of SBRT such as Dr. Cuttino can provide.

Best
Peter

Link 1 : "SBRT"
or Go To
https://www.urologytimes.com/view/dr-spratt-on-the-evolving-paradigm-of-radiation-therapy-in-prostate-cancer
*
The final stages of the Prostate cancer Battle may be with NeuroEndocrine PCa

Us Too Warriors,

This is not a battle I have looked into and it is not well studied or described. I will attach a paper that discusses it - It is the best I have seen. I do not know that I have it but my scan and time on treatment suggest it is possible ???

These are the details I know:

I failed castration resistant treatment 3 years ago = enough time for Neuroendocrine Prostate cancer to develop. A PSMA scan of my body last week found a 1cm spot on my lung that did not absorb Radioactive PSMA fluid so is not PSMA producing like a normal Prostate cancer. It could be Neuroendocrine prostate cancer which the attached paper says I am ripe for or It could be another Melanoma met which keep popping up - of which I have had 10 already which seem to disappear with Immunotherapy, SBRT, Surgery (Brain Mets) and High dose Vitamin C infusions (up to 125 grams). More SBRT to the lung met seems the best choice now with continued Immunotherapy and Vitamin C.

I will be getting 10 grey of SBRT every other day starting next week for 5 shots - for a total of 50 Grey. I also see a dermatologist for inspection and a Skin surgeon for mohs surgery for Squamous cell cancer on my hand and arm.

I Have a recessive red hair Gene and that plus the sun playing tennis and soccer are the root of my problems.

Wish me the best over the next few weeks. Peter (See Paper Below)

Best
Peter

Link 1 : "NeuroEndocrine"
or Go To
https://pubmed.ncbi.nlm.nih.gov/25225419/
*
Metformin reduces deaths & extends hormone sensitvity before changing to deadly castration resistant PCa

Us Too Warriors,

In January 2018, I started treatment with 150mg of Casodex and 2000mg of metformin/day and for 33months I had a 99% reduction in my PSA from 12.2 down to 0.015. My metastasis in my hip seems to have disappeared in my PSMA scan this month compared to an Axium scan Dec.2017 This is very similar to the study reported below except that I used a higher dose of metformin and Casodex and no(DAMN) Lupron. It stopped working after 33 months in the fall of 2020. I have stayed on it with PSA doubling every 5months which is better than every month if I get off. But the PSMA scan this month showed no PCA?? Metformin is a prescription I got my General practitioner give me. It is usually used for people with high blood sugar levels of type 2 diabetes. With my diet I have low sugar of levels 93 units or less. You do not want your sugar levels less than about 70 units or you could pass out.

Best
Peter

Link 1 : "Metformin"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 23 Metformin.pdf
*******
ADT Side Effects Check List from another Us Too group in Colorado (Fort Collins)

Us Too Warriors,

Many of you know I am not doing the ADT treatment because of its side effects that can affect your Mind, Muscles and heart function, quality of Life and Life itself thru increased heart attacks, strokes, alzheimer's, bone loss, MUSCLE WASTING, FRAILTY and death from falls.

I have avoided these problems to a large degree by saying NO to my oncologist; including twice this year; I told him I am not going there. I have to do a lot of research to make my choice work - in terms of supplements, prescription, diet and exercise. This is not for every one and ADT will help men for a while who can not help themselves.

YOU WILL NEED TO DO THIS ALSO WHILE YOU ARE ON ADT TO MAKE IT WORK FOR A WHILE.

THE CHECKLIST THAT FOLLOWS WILL HELP YOU MANAGE ADT TREATMENT. BUT I WOULD SUGGEST THAT YOU INCREASE YOUR VITAMIN d3 LEVELS TO 6000 T0 8000 IU FOR A COUPLE OF MONTHS BEFORE CHECKING YOUR BLOOD LEVELS(TRY FOR 60 T0 80 ng BLOOD LEVEL IS WHAT YOU WANT TO MAINTAIN) AND TAKE ONE LEF.ORG MEGA K2 PILL PER DAY TO KEEP CALCIUM DEPOSITS OUT OF YOUR BLOOD VESSELS.

Best
Peter

Link 1 : "Checklist"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 23 Androgen Deprivation Therapy Checklist for Men.pdf
*
Virtual online PCa conference Free
One of the best available -It is the same one that 16 of our members went to at VB in 2017

Us Too Warriors,

Do not miss this conference online Nov 4 all day.

Best
Peter

Link 1 : "PCa Conference"
or Go To
https://www.eventbrite.com/e/prostate-cancer-abcs-fl-a-free-conference-for-patients-caregivers-tickets-636124083257
*
Study Shows How Morphine May Contribute to Bone Loss and Cancer-Induced Bone Pain and Death

Us Too Warriors,

Morphine is often used in Hospice for PCa which may hassen death but the attached article suggests it may not be good for pain. Jerry Dean was suffering with pain in hospice near the end. I do not know if he was on Morphine but it looks as if you would need to be knocked out with morphine not to feel the bone pain it would cause.
Best
Peter

Link 1 : "Morphine"
or Go To
https://theoncologynurse.com/issue-archive/2023/august-2023-vol-16-no-5/19635-study-shows-how-morphine-may-contribute-to-bone-loss-and-cancer-induced-bone-pain
*
Zero Cancer- ADT educational Book/Program to make Lupron /AntiAndrogens work Better

Us Too Warriors,

Many of you know that I am not a fan of ADT because of the possible side effects to the Brain, Heart is muscle, body muscles and fatigue that damage the quality of life. But for some men it may extend life and if the man is disciplined enough he may be able to fight off the life destroying side effects but it is not easy!!! For example to prevent muscle loss you may need to take supplements like CoQ10 (200mg/d) besides exercise of = ~>30min/d which becomes very hard if you have fatigue from ADT. Go to this website below to learn more
Best
Peter

Link 1 : "Book/Program"
or Go To
https://www.lifeonadt.com/
**
Zero cancer, Benefits of Differnt forms of Magnesium in Prostate cancer and other health Issue.

Us Too Warriors,

I have recently been supplementing with magnesium salts for several health issues and one of our members inquired about a stroke he had from high blood pressure. I was aware that magnesium supplements can lower blood pressure so Investigated further and found it has other health benefits depending on the salt form: see below and the video attached. Form: Mg Citrate- Bowel movement; Mg Glycinate- Calming; Mg Sulfate -Afib; Mg Threonate - Brain aging; MgTaurate and Malate - fibromyalgia/pain and Mg Threonate for - Brain aging protection. Magnesium in general activates Vitamin D3 (25 Vitamin D) to the Active form of Vitamin D =1,25 OH vitamin D (Calcitriol) which fights PCa (which I also take in a prescription besides the inactive over the counter Vitamin D3 that your liver and kidney need to activate). Magnesium can reduce calcium in blood vessels and thus reduce blood pressure/hardening of the arteries. It is known that high Calcium in the diet can make for more PCa and more aggressive PCa. The Magnesium dose is 420 mg/d for men and 350 mg/d for women. The Form you take depends on the issues concerning your health. I am presently taking Mg Citrate, Mg Malate, Mg Threonate and Mg Sulfate for my health issues. Mg is best taken with food at night. Mg ions may have benefits as a possible therapeutic agent in the management of glaucoma, cataract and diabetic retinopathy. If you have less than stage 3 kidney function that is GFR less<30 you should not supplement with Mg.
Best
Peter

Link 1 : "Magnesium"
or Go To
https://news.vanderbilt.edu/2011/06/03/magnesium-affects-prostate-cancer-risk/
*
Link 2 : "Magnesium 2"
or Go To
https://www.youtube.com/watch?v=Z4ohSzChgII
***************
You Tube Video Explaining how sugar affects our health and fighting cancer
All Sodas are High Frutose Corn Syrup-Coke, Pepsi, Dr. Pepper etc etc since about 1980!!!!!

Us Too Warriors,

High Fructose corn syrup is the worst bad acting actor sugar that kills people that are skinny or fat and grows cancer and diabetes etc. But Sucrose also is part Fructose and glucose is bad if not as bad as Fructose.

The following video will explain how a fatty liver is produced by fructose just as if you were a heavy drinker and how you can become insulin resistant with a high fructose diet. You will need to check the contents of what you buy at the grocery store if you do not already.
Best
Peter

Link 1 : "High Frutose Corn Syrup"
or Go To
https://www.youtube.com/watch?v=Lpsmq6S7BMQ

New hope for a Break thru for For Immunotherapy for Prostate cancer

Us Too Warriors,

Researchers determined the safety and antitumor ability of genetically Engineered CAR T cells that circumvent immune System
(When developing chimeric antigen receptor (CAR) T cell therapy, researchers take T cells from a patient’s blood and engineer them to target specific antigens presented on cancer cells. These cutting-edge therapies have successfully fought blood cancers, killing the cells that they target. However, they are less effective at treating solid tumors due to the solid tumor microenvironment (TME), which suppresses the body’s immune system.)
Best
Peter

Link 1 : "CAR T Cells Break "
or Go To
https://www.the-scientist.com/news-opinion/armored-car-t-cells-break-through-immune-suppression-in-solid-tumors-70545#:~:text=In%20this%20clinical%20trial%2C%20the%20occurrence%20of%20cytokine,the%20increased%20Tgf%C3%9F%20signaling%20in%20the%20immunosuppressive%20TME.

Video explaining the use of high Dose Melatonin to stop Advanced PCa(& other cancers) Growth

Us Too Warriors,

I have used melatonin for many years to slow my cancer. (this may be important if you have advanced PCa.) I started with 20 mg per night and now I am at 40 mg now. But the video suggests a very high dose like 180 mg/night. Also, with my high number (10+) of CT, MRI and Pet scans radiation, the video suggests 300 mg before the scan to block radiation Damage. Some people(<10%?) have trouble with melatonin even at low doses <10mg,so try low doses before you try higher to see if you can handle it? I Plan to work my way up slowly to higher doses. It does not require a prescription and this site sells a 60mg pill if you are so inclined?

"www.scientifichealthsolutions.com"

A word of Caution, Melatonin is a blood thinner that can lead to excess bleeding if you have stomach bleeds or hemorrhoids. Aspirin, Aleve ( Nsaids) cause stomach bleeds especially with alcohol use. I use high dose (mega)Vitamin K2 (MK4) from Lef.org for stopping bleeding and getting calcium (hardening of my arteries) out of my arteries from Vitamin D higher adsorption of calcium. Blood thinning is one of the 8 ways claimed in the Video to slow cancer growth with melatonin.

Best
Peter

Dr. Frank Shallenberger, the president of the American Ozone Therapy Association, will demonstrate the crucial role of oxidative therapies in the maintenance and enhancement of mitochondrial energy production, an absolute necessity for better health and optimal aging.

Link 1 : "Optimizing Oxidation in the Care of Chronically Ill Patients"
or Go To
https://www.youtube.com/watch?feature=youtu.be&v=Roh4lQXneQg&fbclid=IwAR36FZEUynwOGS7C9-6unwT9RWr-XohL4fqylMAgUV2fzvMyN3dN7Oxsfgo&app=desktop

SBRT added to Abiratrone after Biochemical recurrence mets is a strong benefit over Abiraterone alone

Us Too Warriors,

Consider adding SBRT treatment when you can to metastasis treatment when possible see website to follow.
Best
Peter

The addition of SBRT to upfront abiraterone acetate and prednisone (AAP) reduced the risk of disease progression or death by 65% compared with AAP alone in patients with oligometastatic castration-resistant prostate cancer.

Link 1 : "SBRT"
or Go To
https://www.urologytimes.com/view/adding-sbrt-to-frontline-abiraterone-shows-benefit-in-oligometastatic-mcrpc?utm_source=sfmc&utm_medium=email&utm_campaign=09262023_UT_PHO-23-URD0421_Monthly%20eNL&eKey=cGNtb29uQHZjdS5lZHU=

Chart of the relative effect of radiation on different body tissues

Us Too Warriors,

The website to follow shows the relative effect radiation on tissue which may show up in the year after treatment or later in the form of fibrous tissue which can compromise the function of the tissue site as the fibers form in the area. Best
Peter

Link 1 : "Chart"
or Go To
https://www.env.go.jp/en/chemi/rhm/basic-info/1st/03-07-02.html

Short video describing when a PSMA Pet CT is appropriate

Us Too Warriors,

A Pet is appropriate if you have these conditions.
1. you have Biochemical recurrence after surgery/radiation,
2. You have 50% of your biopsy cores positive on diagnosis.
3. Your Gleason is 4+ 3 or worse on diagnosis.
4. Your PSA is > 10 on diagnosis.
5. In My case, it checks if a couple of questionable spots on
my backbone and lung are PCa active or possibly Melanoma?? as
PSMA binds to prostate cancer. I will get the test in November some time.

See the website Below (4 minute Video)

Best
Peter

Link 1 : "video"
or Go To
https://www.urologytimes.com/view/optimizing-psma-pet-ct-targeted-imaging-guidelines?utm_source=sfmc&utm_medium=email&utm_campaign=09232023_UT_TEL-23-URV0151_Prostate%20UroView&eKey=cGNtb29uQHZjdS5lZHU=

Website that discusses Early Detection of Many Cancers to prevent them from taking your life -Valuable for your Children

Us Too Warriors,

The following website is an up to date discussion of detecting many different cancers which is valuable for younger people to be aware of future dangers and to keep us aware of what we can do to avoid future problems and help our families. It has a good discussion of prostate cancer detection which may be of value to male children in your families. Check it out to see how you can detect cancers to protect yourself and families.

Best
Peter

Link 1 : "Early Detection"
or Go To
https://www.youtube.com/watch?v=v8VFTQ74bqo&t=226s

Paper on use of Hi Dose Vitamin C Infusion to Fight cancers

Us Too Warriors,

Vitamin C IV at high doses produces Hydrogen peroxide that can kill cancer and may stop Mets. I have been using it as much as 4 times a week in the early summer at Up to 100 gms per dose and now I am at 125 gms twice a week. It can be used by itself or with other standard treatments. It costs about $250/100gm not covered by insurance. It works well with chemoTherapy. I am using it with my Immunotherapy which is new so no clinic data is available for it. But In general it may be needed and work best when the cancer is more advanced and you are dealing with CRPCa which does not have any good long lasting treatments yet or Metastases or hospice care. It may extend life or reduce side effects of pain, fatigue and upset from the meds that may occur with advanced cancers. Go to the website below for discussion on the use of IV Vitamin C with cancers.

Best
Peter

Link 1 : "Hi Dose Vitamin C"
or Go To
https://jeccr.biomedcentral.com/articles/10.1186/s13046-021-02134-y

Factors that Influence PCa Growth Chart

Us Too Warriors,

Check the website below - For factors that effect PCa Growth and eliminate those you can to slow cancer growth.

Best
Peter

Link 1 : "PCa Growth Chart"
or Go To
http://2.bp.blogspot.com/-9sxlZxDAEy4/UpQbpDiE-zI/AAAAAAAAAB8/Ai0K_1M3EhU/s1600/Prostate-Cancer-Risk-Factors.jpg
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Blog comments on using Orgovyx / Relugolix vs. Glucose rise in PCa treatment

Us Too Warriors,

It seems you need to monitor your diet carefully on these drugs to keep your sugar under control.

Orgovyx/Relugolix vs. Glucose

Best
Peter

Link 1 : "Blog Comments"
or Go To
http://rvaprostatecancersupport.org/PDF/9723Blog.pdf

Novel Immunotherapy Agent Safe, Shows Promise Against High-Risk Prostate Cancers

Us Too Warriors,

A new drug, a monoclonal antibody known as enoblituzumab, is safe in men with aggressive prostate cancer and may induce clinical activity against cancer throughout the body, according to a phase 2 study led by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy. If confirmed in additional studies, enoblituzumab could become the first promising antibody-based immunotherapy agent against prostate cancer.

Best
Peter

Link 1 : "Johns Hopkins Kimmel Cancer Center"
or Go To
https://www.hopkinsmedicine.org/kimmel_cancer_center/

Link 2 : "Bloomberg/Kimmel Institute for Cancer Immunotherapy"
or Go To
https://www.hopkinsmedicine.org/dev/xtest_shaun/bki-demo/bki-index.html

Video of Multiple Cancer detections processes by Dr Peter Attia

Us Too Warriors,

It is evident that men in our group can be subjected to more than Prostate cancer and it is wise to be knowledgeable other cancers.

With this in mind I have added an excellent Video Information on detecting multiple other cancers see below.

Best
Peter

Link 1 : "Multiple Cancer Detections"
or Go To
http://rvaprostatecancersupport.org/PDF/8282023MultipleCancerDetectionsVideos.pdf
********************************************
Blog on Immunotherapy development, the way of the future
for men who become CRPC on Standard of Care as there are no good options left

Us Too Warriors,

THE state of Immunotherapy , how we got here and where we are going - Peter Attia

Some great info about cancer at the cell level

Current state of treatments for metastatic cancer and reasons for the lack of progress over the decades [22:30];

The interplay between the immune system and cancer cells [32:00];

Different ways cancer can suppress the immune response, and how immunotherapy can combat cancer’s evasive tactics [39:30];

Elimination of a substantial portion of cancers through immune cell engineering faces challenges of specificity, cost, and scalability [52:15];

Why TIL therapy isn’t always effective, and the necessity for multimodality therapy to address various aspects of the cancer microenvironment [1:01:00];

The potential developments in cancer therapy over the next five years: T-cell activation, metabolic interventions, targeting tumor microenvironments, and more [1:06:30];

The challenge of treating metastatic cancer underscores the importance of early detection to improve survivability [1:19:15];

Liquid biopsies for early detection of cancer and determining the possible tissue of origin

Best
Peter

Link 1 : "State of Immunotherapy"
or Go To
https://peterattiamd.com/?utm_source=podcast-email&utm_medium=email&utm_campaign=230821-pod-keithflaherty2&utm_content=230821-pod-keithflaherty2-email-nonsubs&mc_cid=a76876ebc7&mc_eid=ee5f4da697&s=state%20of%20Immunotherapy%20%2C%20how%20we%20got%20here%20and%20where%20we%20are%20going
****
Zero Cancer Paper - google website on Use Of Vitamin K2 to fight cancers

Us Too Warriors,

I have been recommending Vitamin K2 to be use with high dose Vitamin D3 for at least 15 years to put calcium in your bones at not in veins to prevent hardening of the arteries and damage the heart from calcium deposited by higher calcium absorption with Vitamin D3, But in the website that follows shows that Vitamin K2 fights Cancer pathways too.

Vitamin k2 of the form MK7 is best absorbed and recommended as the best form to Buy. See the follow paper for more information,

Best
Peter

Abstract

Despite the availability of multiple therapeutic methods for patients with cancer, the long-term prognosis is not satisfactory in a number of different cancer types. Vitamin K2 (VK2), which exerts anticancer effects on a number of cancer cell lines, is considered to be a prospective novel agent for the treatment of cancer. The present review aims to summarize the results of studies in which VK2 was administered either to patients with cancer or animals inoculated with cancerous cells, particularly investigating the inhibitory effects of VK2 on cancerous cells, primarily involving cell-cycle arrest, cell differentiation, apoptosis, autophagy and invasion. The present review summarizes evidence stating that treatment with VK2 could positively inhibit the growth of cancer cells, making it a potentially useful approach for the prevention and clinical treatment of cancer. Additionally, the combination treatment of VK2 and established chemotherapeutics may achieve better results, with fewer side effects. Therefore, more attention should be paid to the effects of micronutrients on tumors.

Link 1 : "Vitamin K2"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958717/

Zero cancer- Possible Clinical study with only Active treatment no Placebo for CRPC

Us Too Warriors,

Check out the website Below.

Best
Peter

About the Study

The TAMARACK study will help us learn if an investigational intravenous (IV) medicine is effective and tolerable for the treatment of metastatic CRPC that has progressed during or after treatment with enzalutamide, abiraterone, or apalutamide in addition to docetaxel.

The study medicine is an antibody with an anti-cancer drug attached, called an antibody-drug conjugate (ADC). Antibodies are proteins produced by the body's immune system to fight infections or kill cancer cells. The antibody portion of the ADC allows the anti-cancer drug to attach to and kill cancer cells. The antibody targets cancer cells specifically, which helps prevent the anti-cancer drug from hurting normal cells.

The study medicine has not been approved for use outside of clinical trials.

Link 1 : "Possible Clinical Study"
or Go To
https://www.tamarackstudy.com

Integrative Medicine Doctor answers Cancer questions live over the internet to callers open to sign up Audience at 7 Pm Thursday

Us Too Warriors,

Check out the website Below.

Best
Peter

Hear Real Questions From Real People The Going Integrative Community provides a place where people concerned with cancer and chronic disease are able to ask the questions they’ve always wanted to ask, of the best practitioners in the world… And you’re invited to watch and participate in this call, for free!!

Link 1 : "Integrative Medicine Doctor"
or Go To
https://drmichaelhummel.goingintegrativeplus.com/watch-dr-michael-hummel-live-going-integrative-plus-membership-hummel/?via=dr-michael-hummel

"Map of Medicine" website spells out the many parts of medicine

Us Too Warriors,

Check out the website Below.

Best
Peter

A Comment on the Video from the website - As an aspiring doctor and someone who has a crazy fixation for medicine, I can't thank you enough for this video. I've been trying to find something like this for ages. Nothing of this nature has ever been made and posted on youtube ever; and what's crazy is that it's not even from a doctor. Thank you for such a great video.

Link 1 : "Map of Medicine"
or Go To
https://www.youtube.com/watch?v=CkwSeMrOPjc

More Info about Immunotherapy Research

Us Too Warriors,

Check out the website Below.

Best
Peter

Overview

The majority of prostate cancers are diagnosed at an early stage, such that patients can be closely monitored without treatment, or are cured with local treatment. However, recurrent and metastatic disease often progresses to an advanced stage and becomes resistant to therapy, known as metastatic castration-resistant prostate cancer (mCRPC): nearly 35,000 patients are projected to die of prostate cancer in 2023. Novel approaches to treatment are urgently needed.

Now, research funded by the 2016 Izzy Englander – PCF Challenge Award has defined a mechanism that prostate cancers use to reprogram the immune system, thus allowing them to grow unchecked. PCF Challenge Award recipient, Akash Patnaik, MD, PhD, MMSc, (University of Chicago) and team identified a promising immunotherapy-based combination treatment to prevent the cancer cells from developing this ability. These findings were recently published in the journal Clinical Cancer Research.

To See the Website - Click on the Link Below:

Link 1 : "Immunotherapy Research"
or Go To
http://www.pcf.org/c/promising-personalized-targeted-immunotherapy-combination-treatment-identified-for-an-aggressive-form-of-advanced-prostate-cancer/

What COMPLETE BLOOD COUNT -TELLS YOU ?

Us Too Warriors,

Check out the website Below.

Best
Peter

Overview

A complete blood count (CBC) is a blood test. It's used to look at overall health and find a wide range of conditions, including anemia, infection and leukemia.

A complete blood count test measures the following:

Red blood cells, which carry oxygen
White blood cells, which fight infection
Hemoglobin, the oxygen-carrying protein in red blood cells
Hematocrit, the amount of red blood cells in the blood
Platelets, which help blood to clot
A complete blood count can show unusual increases or decreases in cell counts. Those changes might point to a medical condition that calls for more testing.

Products & Services
Book: Mayo Clinic Family Health Book, 5th Edition

To See the Website - Click on the Link Below:

Link 1 : "COMPLETE BLOOD COUNT"
or Go To
https://www.mayoclinic.org/tests-procedures/complete-blood-count/about/pac-20384919

Dr Meyers recomendation Video on use of Metformin

Us Too Warriors,

Dr.Meyers Video suggest the use of metformin to fight PCa and reduce aging.

I have used metformin1500 to 2000 mg/day for the last 10+ years which has helped keep my weight equal to my high school weight to 10 lbs above when I can get enough exercise. My special scale suggests my biological age is 5 years less than my chronicle age. Metformin may be helping? A1c<~5.6

Best
Peter

To See the Video - Click on the Link Below:

Link 1 : "Video"
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/148048463/snuffy-myers-on-metformin

Zytiga best for Visceral Metastasis 20 -30% liver,lungs, adrenal glands, peritoneum, pleura, brain and dura

Us Too Warriors,

See attached paper for information

Visceral Metastasis Predicts Response to New Hormonal Agents in Metastatic Castration-Sensitive Prostate Cancer.

Best
Peter

To See the Paper - Click on the Link Below:

Link 1 : "Paper/Website"
or Go To
https://pubmed.ncbi.nlm.nih.gov/37084289/

PCa 2nd Generation Androgen Blockers to cancer cells have cognitive, fatigue & Fall toxicity

Us Too Warriors,

Recently my oncologist suggested I go from 1st generation androgen Blocker,Casodex, to Xtandi, a second generation androgen Blocker. I told him not to waste his time, because my older brother (thirty years with PCa) who was on this Xtandi until his fatigue was so bad he had to quit it and his cognitive function was made steadily worse.

Open the following website to Read the research describing these Problems.

Best
Peter

To See the Website - Click on the Link Below:
(Analysis further links prostate cancer drug class with cognitive and functional toxicity)
Link 1 : "Website"
or Go To
https://www.urologytimes.com/view/analysis-further-links-prostate-cancer-drug-class-with-cognitive-and-functional-toxicity?utm_source=sfmc&utm_medium=email&utm_campaign=07082023_UT_BOS-23-URD0446_Boston%20Scientific_Kidney%20Stone%20TRC&eKey=cGNtb29uQHZjdS5lZHU=
**********************************************************************************
Use of LDH Blood Test in PCa Blog- Useful in Advance cancer with metasatasis

Us Too Warriors,

LDH goes up with metastasis of any cancers. My LDH was 50% above the maximum blood normal high value with 10 metastasis of melanoma. Now my melanoma mets are gone, my LDH is only 25% of the high normal blood value. And my Metastasis in Rt hip is gone too. Check below.

Best
Peter
*
Value of LDH

fourputt profile image
fourputt•
1 day ago•9 Replies
I've been dealing with PCA 11 years and I've seen a number of doctors along the way but never have discussed or had my LDH tested. A young oncologist where I had my PSMA scan requested PSA, testosterone and LDH tests to go along with the scan. My LDH was at the low end of the "range" (but we still didn't discuss it LOL). My question is what part (if any) will/should LDH play in my treatment going forward ? Does it have a prognostic value, help monitor the effectiveness of treatments being administered or what ?

Reply
More

dhccpa profile imagedhccpa in reply to CAMPSOUPS6 hours ago
I tried to talk my MO into checking it but he resisted, saying it was too non-specific and other readings were good. I let it pass at the time. What does your MO say about it?

Reply
More

martinbe profile imagemartinbe1 hour ago
Cancer are primarily anaerobic. When they ferment glucose, they produce high levels of lactate. Lactate dehydrogenase (LDH) is the enzyme that degrades lactate. So, if there is a lot of cancer activity the LDH rises.

**************************************
Website discussing Testosterone treatment as away of reversing mCRPC

Us Too Warriors,

The following website discusses treatment of advanced cancers with testosterone. It is very positive but in my reading of this treatment it works in about 1/3 of men. I hope a way will be developed to determine which men it will work in to slow cancer.

Check this website. T definitely provides a better quality of life than ADT as I can attest too with my high level of testosterone naturally without added testosterone.

Best
Peter

To See the Website - Click on the Link Below:

Link 1 : "Website"
or Go To
https://www.youtube.com/watch?v=GNCpG1fkMBA&t=8798s

PCRI YouTube Videos covering Many aspects of PCa Treatment by Dr Scholz -Good Doc treats only PCa

Us Too Warriors,

Check out the Videos. There should be one that applies to your treatment situation. I have followed his work for about 18 years and he had Dr.Meyers present at many of his Conferences

Best
Peter

To See the Videos - Click on the Link Below:

Link 1 : "Videos"
or Go To
https://www.youtube.com/thepcri

YouTube Video of One man's experience with incontinence and ED after PCa DeVince Surgery

Us Too Warriors,

An unvarnished straight forward presentation of a fifty something man's experience dealing with incontinence and ED.

Best
Peter

To See More Info - Click on the Link Below:

1 Year Post-0p �� Prostate Cancer , Erectile Dysfunction & Urinary Incontinency
Today I will discuss my Post-Op for all three issues I had after having a Radical Prostatectomy Surgery

Link 1 : "Incontinence and ED"
or Go To
https://www.youtube.com/watch?v=TToiMjHpxg0

FDA approved an over the counter cream for ED works for65% of men w/ED -no Prescription needed

Us Too Warriors,

Men with erectile dysfunction will now have the option of using a topical gel to treat the condition.

The U.S. Food and Drug Administration has approved over-the-counter marketing for the product, called Eroxon, as a first-of-its-kind medical product. The British pharmaceutical firm Futura Medical makes the gel.

"FDA set a very high standard in evaluating the effectiveness and safety of De Novo Medical Devices. I am delighted that we met this standard," Futura CEO James Barder said in a news release on Monday.

About 30 million American men are affected by erectile dysfunction, where they're not able to get or keep an erection for sexual activity.

This new gel will be sold in a single-dose tube, CNN reported.

It should be applied to the head of the penis before sex. Users may be able to become erect within 10 minutes and maintain that for long enough to have sex in about 65% of those who use it, according to the company.

The product is already sold in Belgium and the United Kingdom, where it costs the equivalent of $31.22 in U.S. dollars for a four-pack, CNN reported.

"We don't have specific pricing details yet, as the pricing will ultimately be determined by the partner who launches Eroxon in the U.S.," a company spokesman told CNN.

The timeline for when the product will be in the United States is unknown but it could be 2025, CNN reported.

Diseases such as Type 2 diabetes can contribute to erectile dysfunction, as can certain medications, anxiety disorders, smoking, drinking excessive alcohol, being overweight.

Best
Peter

To See More Info - Click on the Link Below:

Link 1 : "ED"
or Go To
https://www.niddk.nih.gov/health-information/urologic-diseases/erectile-dysfunction/symptoms-causes
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Prescription Vitamin D = 1,25 OH Vitamin D is "Active" in the body and need not go thru liver and kidneys

Us Too Warriors,

Over the Counter 25 OH Vitamin D3, you can buy at drug stores without a prescription and it is not active in the body to change/produce genes functioning until it is processed in your liver and kidneys.. I will be discussing these vitamin Ds tomorrow at the meeting.

I started taking Active 1,25 OH Vitamin D before about 2010 after reading a clinical article by a Dr. DeBeer in Washington State printed in 2008. He had a small group of 8 men with PCa which gave a low dose 0.5 mcg/d pill per day. 7 of the 8 had a drop in their PSA, and I got my VCU doctor to prescribe it for me at the time and ever since I along with that take a good dose of Vitamin K2 to keep calcium out (from all forms of Vitamin D3 Prescription and over the counter) of my veins. I also check my blood level of calcium for every blood test and avoid dairy to keep calcium levels lower.

These precautions are extremely important for both prescription and over the counter vitamin D. Calcium in veins hurts the heart and blocks blood flow especially In the carotid artery to the brain. My carotid arteries are 16% and 49% blocked. If it gets above 70% the doctors do surgery to unblock them. More at the meeting tomorrow

See paper below see the value of vitamin D. Its improvement of my immune system may be a reason I am defeating melanoma,

Best
Peter

Abstract:
Epidemiological studies indicate that vitamin D insufficiency could have an etiological role in prostate cancer. In addition, calcitriol, used in combination with currently available drugs, has the potential to potentiate their anticancer effects or act synergistically by inhibiting distinct mechanisms involved in prostate cancer growth. Clinical data have not yet provided sufficient evidence to demonstrate benefit of vitamin D due to the limited and underpowered studies that have been published to date. Here, we review the preclinical and clinical studies that describe the activity of calcitriol, applied either alone or in combination and assessed the mechanistic basis of pharmacodynamic and pharmacokinetic interactions with calcitriol. Important considerations for calcitriol use in combination therapy with respect to safety and clinical outcomes have been discussed. Many of these combinations have therapeutic potential for the treatment of several cancer types and it is anticipated that future clinical research will put emphasis on well‑designed clinical trials to establish efficacy.

To See the Info - Click on the Link Below:

Link 1 : "Vit D"
or Go To
https://pubmed.ncbi.nlm.nih.gov/26918053/#:~:text=Epidemiological%20studies%20indicate%20that%20vitamin%20D%20insufficiency%20could,inhibiting%20distinct%20mechanisms%20involved%20in%20prostate%20cancer%20growth.
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If you are at the stage of mCrPCa I would you look into immunotherapy-Suggested Clinic??

Us Too Warriors,

Most treatments of mCrPCa are short lived (1 Year or less) whether Chemo or ADT related. With my experience with Opdivo for my Melanoma that has also worked to lower my PSa, I am going to suggest an Arizona Clinic that claims to use Immunotherapy for PCa. My opdivo treatment works in about 30% of advanced PCa men in a Clinic study.

See below for more inform

Advanced Targeted Immunotherapy Options Enhance Precision Cancer Treatment

Best
Peter

To See the Info - Click on the Link Below:

Link 1 : "Clinic??"
or Go To
https://www.envita.com/conditions/cancer-treatment
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One of Dr Meyer's tricks of Using Dostinex to Stop mCrPCa is proven in the attached paper

Us Too Warriors,

I had used a prescription for Dostinex (also called Cabergoline) for fighting PCa for a number of Years.

I had run out recently while on Melanoma treatments. I got a Call from my ONCa Nurse Tuesday asking if I want to get refills not knowing its value I said NO and today the paper attached below showed up on my Computer which shows that is exactly what

I need to stop my mCrPCa. I am getting a new prescription Today ! ! !

Best
Peter

To See the Info - Click on the Link Below:

Link 1 : "Dostinex"
or Go To
https://pubmed.ncbi.nlm.nih.gov/31211288/#:~:text=He%20was%20treated%20with%20cabergoline%20%28dopamine%20agonist%29%20treatment%2C,%28circulating%20tumor%20cells%29%20decreased%20from%20count%3D5.4%20to%20count%3D0.
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Research has finally Proven Vitamin D3 is A MIRACLE in PREVENTING DEATH from Prostate cancer

Us Too Warriors,

WARRIORS who have been Members from 2009 know how I have pushed men to get high levels of vitamin D3 supplements and to get blood tested to prove their levels are high enough (I sure they are sick of my Preaching and saying to take vitamin K2 along with D3 to keep calcium out of their arteries.) Well my preaching is justified if you view the Attached Video.

It may save your LIFE as it has mine for nearly 30 years with my 100ng/ml of Blood level of Vitamin D3.

Best
Peter

To See the Video - Click on the Link Below:

Link 1 : "Vit D"
or Go To
https://www.youtube.com/watch?v=YjtROU1MeTo
*
Ursolic Acid against Prostate and Urogenital Cancers: A Review of In Vitro and In Vivo Studies

Us Too Warriors,

Dr Meyers in one of his last emails to me pointed out that Ursolic Acid fights PCa. Rosemary spices are a good source of Ursolic acid so I planted one in my garden in 2020 that is now 5 feet by 5 feet. Now several times a week, I cut sprigs, strip off needles and cut them into small pieces(with scissors) and cook them into my food. You can order pills for ursolic Acid from Swanson Inc. Notice That Our meetings during the summer (June thru Oct) are in the evenings - I will be there at 6:45 PM if you want to discuss anything with me before the meetings. I will discuss many more supplements at this meeting that fight PCa.

See paper attached below for benefits of Ursolic Acid. Prostate cancer bone mets are usually osteoblast but melanoma are usually osteolytic.

Best
Peter

To See the Paper - Click on the Link Below:

Link 1 : "Ursolic Acid"
or Go To
https://pubmed.ncbi.nlm.nih.gov/37108576/
*******************************************
I.V. Vitamin C infusion in slowing cancer and my PSA and Alkaline Phosphate rise on cancer progressi

Us Too Warriors,

Attached below is paper below showing that Vitamin C iv infusion can slow prostate cancer even when there are metastases. It tends to work best when you have infusion at high doses~ 100 gm per session and more days a week. I have found two locations for this treatment- One A Drip Bar in the Westend off that does maximum of 75 gms twice a week after blood test and working your way up at 25 gms, & 50 gms for several weeks until you get to 75gms for about 2 months maximum. So starting January, my month + incapacitated & in the hospital and building my Vitamin C level up I had my last infusion today at the Drip bar. But starting in April, I found a Doctor Mary Burton *Beauty Awakened Practice" who I like better on Midlothian Turnpike who accepts my prior blood tests at which I can receive 100gms/ infusion. Over the Last 2 Months I've been getting infusions from both sites. I get a new scan first of June and expect I will go for 2 treatments with Dr Burton at 100gms each per week for the near future. The cost is about $220 per session that is not paid for by insurances/medicare.

My PSa was 0.593 in July 2022 after doubling every 5 months for 2.5 years from my low of 0.015 after two years on Casodex monotherapy ( no Lupron but kept plenty of testosterone) after starting with a metastasis and PSA_12.2 Dec 2017.

My PSa should be today if it kept doubling at the same rate (every 5months since last July) it should equal a PSA =2.4 but it is only 0.6 as of April 2093 and that is even with being in the hospital and it doubling every two weeks when I can not take my failed casodex etc because the hospital would not give me my casodex, calcitriol, dutasteride, proscar doxycycline. pravastatin etc.that has still slowed my cancer after my super monotherapy failed.

The casodex when it failed made me castration resistant even without lupron but it still helped because the doubling time with it was every 5 months and without these pills the doubling time was every two weeks !!!!!

For your information there are two other blood tests you should get to monitor your prostate cancer and if your Doctor has not done them for you, you should ask him so you have a baseline level. The first is CRP = C Reactive Protein which is a measure of inflammation in your body. Cancer is an inflammation so if it is high it is a measure your cancer is high.

The year I was diagnosed with melanoma my CRP went from 0.5 to 17.4 Terrible !! That is why I had 10 mets

ALP= ALkaline Phosphatase is a measure of osteoblastic bone growth which when high mean you may be forming bone metastases. Prostate cancer bone mets are usually osteoblast but melanoma are usually osteolytic.

Best
Peter

To See the Paper - Click on the Link Below:

Link 1 : "Link 1"
or Go To
https://pubmed.ncbi.nlm.nih.gov/32102933/
***********************************************************************************
Casodex (150 gm/d) monotherapy for for advanced PCa also improves my melanoma treatment.

Us Too Warriors,

I know of at least 5 members of our support group who are using this monotherapy like mine to keep Testosterone and dihydrotestosterone from attaching to the prostate cancer cell receptors to slow PCa growth/ Psa rise.. It has a similar benefit for melanoma cells that are promoted by testosterones too.
See attached papers below.

Best
Peter

To See the Paperes - Click on the Links Below:

Phase I Study of Androgen Deprivation Therapy in Combination with Anti-PD-1 in Melanoma Patients Pretreated with Anti-PD-1

Link 1 : "Link 1"
or Go To
https://pubmed.ncbi.nlm.nih.gov/36516188/

*
Bicalutamide 150mg: A Review of its Use in the Treatment of Locally Advanced Prostate Cancer

Link 1 : "Link 2"
or Go To
https://www.researchgate.net/publication/7074212_Bicalutamide_150mg_A_Review_of_its_Use_in_the_Treatment_of_Locally_Advanced_Prostate_Cancer
*
Long Covid associated with low Vitamin D Levels

Us Too Warriors,

You now I am a proponent of Vitamin D3 Levels to fight PCa. I have also recently pointed out it rejuvenates Vitamin C that fights viruses. I recommend Vitamin D3 levels of 5000 to 8,000 IU/d to get your blood levels above 50 ng/ml of blood from a 25 OH Vitamin D test. The lower level of 5,000IU for less than forty years old and 8,000 as You approach 60 years old or above. I take 15,000 IU becauses my genes say I only absorb 60 % of the vitamin D3 in my diet + supplements. This puts my blood levels at about 100ng/ml of my blood when tested. A blood test is the best way to determine what level to take after you have taken a supplement for several months. Vitamin D3 helps prevent Depression too. I also try to keep my dairy /cheese low as vitamin d increases calcium absorption which is a problem if it ends up in the arteries = hardening of arteries - blood flow restriction etc. I take vitamin K2 supplements to keep excess calcium out of the arteries and put it in bone to prevent osteoporosis (20% of older men and 50% of older women).
SEE website below

Best
Peter

To See the Website - Click on the Links Below:

Vitamin D deficiency linked to increased risk of developing long COVID

Link 1 : "Link 1"
or Go To
https://www.medicalnewstoday.com/articles/vitamin-d-deficiency-linked-to-increased-risk-of-developing-long-covid
*
Blood Test LDH for PCa monitors progression and new Criteria for radiation treatment Failure

Us Too Warriors,

The papers below can help you monitor your cancer. I found LDH =Lactate Dehydrogenase was very helpful in monitoring my melanoma but the paper attached shows it is helpful for prostate cancer progression monitoring too.

Also If you have had radiation as a primary treatment the second paper helps define progression after primary treatment.

For Surgery as Primary treatment, a PSA > or = 0.2 is the Biochemical criteria for progression after surgery. It is important to start Dutasteride(avodart) before PSA goes above 1.0 to slow your cancer down. I got 14 years before My PSA got above 1.0 and then it rose to 30 in the next four years with metastasis to my right hip before casodex monotherapy dropped my PSa to 0.03 in the next 2 years now three years later My Melanoma immunotherapy has lower my PSA in the last three months from 1.7 to 0.6 the same value I had last July before my diagnosis of Melanoma.

Best
Peter

To See the Websites - Click on the Links Below:

Prognostic Value of Lactate Dehydrogenase in Metastatic Prostate Cancer: A Systematic Review and Meta-analysis

Link 1 : "Link 1"
or Go To
https://pubmed.ncbi.nlm.nih.gov/31558410/
*
PCa Commentary #174 – MANAGING BIOCHEMICAL FAILURE AFTER RADIATION THERAPY — The Importance of Considering Both PSA and PSA Doubling Time.

Link 2: "Link 2"
or Go To
https://www.prostatecancerfree.org/pca-commentary-173-managing-biochemical-failure-after-radiation-therapy-the-importance-of-considering-both-psa-and-psa-doubling-time/

*****************************************
PLUVICTO™ (177Lu vipivotide tetraxetan) consists of lutetium-177

Us Too Warriors,

Lutetium177 is becoming the go to treatment for men with mCRPC who have exhausted other treatments. It does not work for everyone and maybe not for long but it does give hope for some. Jerry Deans flew to Chicago for treatment on a Clinical trial and it seemed to help for a few months For others it may last over a year. I do not know if there are mutations that make it more or less effective. The following information from Duke may help below. Also It is available at Georgetown, UVA and Roanoke. It has a medium survival time of 1 to 2 years and is considered a palliative treatment. There are side effects of nausea and bleeding. Sometimes there may be a supply shortage at different sites?

Best
Peter

To See the Website - Click on the Link Below:

Link 1 : "Duke"
or Go To
https://physicians.dukehealth.org/articles/advanced-prostate-cancer-treatment-extends-lives

*
Video website Address for Modern treatment Choices for 4 + 3 Gleason PCa By Dr Scholtz at PCRI

Us Too Warriors,

I recommend you view this video as it will give you insights on treating PCa with today's knowledge base...

Dr. Scholtz is one of the Doctors like Dr. Meyers he thinks outside the box and weighs the side effects on the quality of life.
Best
Peter

To See the Video - Click on the Link Below:

Link 1 : "Link 1"
or Go To
https://www.youtube.com/watch?v=sXI9JDVuuHU

SBRT radiation looks Promising primary treating gleason 3+4 prostate and Prostate mets

Us Too Warriors,

I had 3 rounds of SBRT treatment to treat my 10 melanoma metastases at different times. To optimize the radiation effectiveness, I started immunotherapy 3 to 5 weeks after SBRT and I did Vitamin C iv infusions right after SBRT ( these decisions were based on research papers). See attached information to follow for PCa. Best Peter

PS. My Melanoma is in remission as none of the mets are lighting up on FDG Pet scan. AMEN!!!
I walked a mile and a half today- the first time since Jan 25 th when I fell after my mile 1 1/2 walk at the end in my driveway and could not wall again until after brain surgery Feb 7th and rehabilitation to the end of March. Life is Good what blessing,
Best
Peter

To Read the Article - Click on the Link Below:

Link 1 : "SBRT"
or Go To
http://rvaprostatecancersupport.org/PDF/5 8 23 SBRT.pdf

************************************
Melatonin to aid Immune system in fighting cancers

Us Too Warriors,

I have been using Melatonin at about 30mg/night for years for sleep. Sleep I think helps the immune system. Melatoin aids the immune system. Papers attached suggested it fights many cancers including Breast. With my use of immunotherapy it should be a bonus.
Best
Peter

To Read the Articles - Click on the Link Below:

*

Boosting immune system against cancer by melatonin: A mechanistic viewpoint

Link 1 : "Link 1"
or Go To
https://pubmed.ncbi.nlm.nih.gov/31629760/

Antitumor effect of melatonin on breast cancer in experimental models: A systematic review

Link 2: "Link 2"
or Go To
https://pubmed.ncbi.nlm.nih.gov/36403922/#:~:text=The%20aim%20of%20this%20systematic%20review%20was%20to,Web%20of%20Science%2C%20and%20Embase%20databases%20were%20used.

************************************
IV Vitamin C slow PCa's PSA & Prostatic Acid Phosphatase (bone mets) raise Vit C best & # of days/wk

Us Too Warriors,

I have been aiming my vitamin C IV at Melanoma mets but it is helping my PCa too.

In the last two months my PSA has dropped 60% from1.7 to 0.7ng/ml. For the last three years, it has been doubling every 5 months. During the last two months I have gone from two Vitamin C infusions a week to 4 x a week and increased the Vitamin c level from 75 grams to 100 grams per infusion. See the attached paper for more Information on how this helped lower my PSA.
Best
Peter

To Read the Article - Click on the Link Below:

Link 1 : "Vitamin C"
or Go To
https://www.ffhdj.com/index.php/ffhd/index

May 16: Genetic & Biomarker Testing

Us Too Warriors,

Sign up for Video On May 16 th on genetic testing of prostate Cancer to be able to treat it better, See how to sign up below
Best
Peter

Date & Time - May 16, 2023 07:30 PM

Description
The good news is that today, advanced testing is available to learn as much as possible about each patient’s prostate cancer. The results can help doctors and patients to understand the likely course and outcome, in some cases to guide treatment, and even to inform family members’ risk of cancer. You may have heard of terms such as genetic testing, genomic testing, biomarkers, gene expression…..or you may not be familiar with any of it.

PCF CEO Charles J. Ryan, MD, speaks with two expert clinicians who are committed to help patients and families understand what it means for their care. People across all stages of the prostate cancer spectrum may be interested in this topic, from newly-diagnosed patients deciding on a treatment plan, to men with metastatic disease seeking additional treatment options. Learn what each type of testing is, how it may apply to you (and your family), how the results can be used to guide you and your physician in making treatment decisions, and what questions to ask your doctor.

To Sign Up - Click on the Link Below:

Link 1 : "Sign Up"
or Go To
https://us06web.zoom.us/webinar/register/WN_A-iS34teSCK6xdlQbonBaA#/registration

Vitamin D3 important for Melanoma just as I have shown in the passed for Prostate cancer

Us Too Warriors,

Vitamin D boosts the response rate for melanoma with Opdivo immunotherapy from 36%for patients with low vitamin D3 to 56% with good vitaminD3. For Prostate cancer, I have long recommended men get their Vitamin D blood levels measured and supplement with vitamin d3 to keep their levels between 60 to 80ng/ml of blood. My genes make me a poor vitamin D absorber at only 60% absorbed so I require a large dose and I also take an active prescription Vitamin D called Calcitriol ( it does not have to go thru my kidneys to be activated, but you have to take low dose as it can increase calcium absorption to too high level. It is important to Take vitamin K2 supplements to keep Calcium out of the blood vessels to prevent hardening of the arteries. I avoid Dairy because of fat and calcium content and because I am not a growing calf anymore. See article below on benefit of Vitamin D levels on Melanoma Immunotherapy.
Best
Peter

To Read the Article - Click on the Link Below:

Link 1 : "Vitamin D"
or Go To
http://rvaprostatecancersupport.org/PDF/4 29 23 Vitamin D.pdf

*
Natural Supplement to Keep P10 gene from being mutated that leads to deadly PCa & failure of Melanoma Immunotherapy

Us Too Warriors,

This supplement can save your life by Keeping P10 Gene active to protect it from mutating. Read this Article from the New York Times to find out more. I know a Doctor in our group die quickly at about 60 years old with PCa because he had a mutation in his P10 gene so it no longer protected him.

I had been taking the Indole-3-Carbinol in the past but as a general protection from cancer without knowing its benefit in protecting P10 function. But now I am adding it back big time ( I still had 4 bottles on my shelf) as it also keeps p10 mutation from causing failure of immunotherapy for melanoma cancer treatment.

The supplement you need to take is - Indole-3-Carbinol.
See NY times article website and the Science articles below for details
Best
Peter

To Go to the Website - Click on the Links Below:

Link 1 : "NY Times"
or Go To
https://www.nytimes.com/2019/05/17/health/gene-mutation-cancer.html

Link 2 : "Indole-3-Carbinol with Resveratrol"
or Go To
https://www.swansonvitamins.com/p/swanson-ultra-indole-3-carbinol-resveratrol-200-mg-60-caps

Immuntherapy for prostate cancer ss you on April 20 at 2 PM for PCa meeting

Us Too Warriors,

In fighting my Melanoma, I have been given Nivolumab (Opdivo). It is not yet available for Advanced PCa But I expect it will be in the next few years as there are 46 ongoing clinical trials with nivolumab and the outlook is very GOOD! See ==>https://ascopubs.org/doi/abs/10.1200/JCO.2023.41.6_suppl.22

The drugs used in these trials include ipilimumab which causes more than 50% autoimmune reactions that can stop treatment 25% of the time. I am using a slightly different drug combination called Opdualag = Nivolumab and Relatlimab which only causes 23% autoimmune reactions and about10% withdrawals. My PSA has dropped from a February high =1.7 to 0.7 in April so it looks to work for both melanoma and my Prostate cancer. Good news for a Change.

Best
Peter

PS
Lactic acid stops this treatment -B Vitamins-B2, 3, 6, 12 and Folate are needed to make this immunotherapy work ! ! ! !
See you Thursday at 2 PM I hope.

To Go to the Website - Click on the Link Below:

Link 1 : "Nivolumab"
or Go To
https://ascopubs.org/doi/abs/10.1200/JCO.2023.41.6_suppl.22

Website of PCa Clinical trials For Immunotherapy Drug Nivolumab

Us Too Warriors,

There are 46 trials studying Nivolumab on the below website at various stages of progress.

I am getting this drug for melanoma treatment by infusion once a month. This drug is considered good for hot cancers like advanced PCa with P53 and P10 mutations.

IT is not available by FDA (Still Needs Approval for PCa), I hope it is FDA approved in near future as men need it or one can sign up for a clinical trial with nivolumab - if you have advanced PCa with these mutations. See website that follows by googling it.

Best
Peter

To Go to the Website - Click on the Link Below:

Link 1 : "Nivolumab"
or Go To
https://clinicaltrials.gov/ct2/results?cond=Prostate+Cancer&term=nivolumab&cntry=&state=&city=&dist=

Website For John Hopkins Paper on Their treatment of 250 CRPC Men with BAT= Bipolar Androgen Therapy ==> 30% success rate

Us Too Warriors,

Check this website below if you have advanced PCa. The 30% success is the best you can find at this late stage.

Bipolar Androgen Therapy Followed by Androgen Receptor Inhibition as Sequential Therapy for Prostate Cancer

Best
Peter

To Go to the Website - Click on the Link Below:

Link 1 : "30% Success"
or Go To
https://academic.oup.com/oncolo/advance-article/doi/10.1093/oncolo/oyad055/7110907

New Pathway found to block the failure of ADT drugs to save the lives of many men that die because their ADT treatment fails (like mine has after a few years).

Us Too Warriors,

As some of you know, I am using Immunotherapy infusion called "Opdualag" to fight My Melanoma. A component,"Nivolumab", of this drug,has been proven to work recently in a prostate cancer clinical trial for PCa too. My PSA dropped from1.7 to 0.9 ng/ml last month. Of course I am throwing everything at it including the kitchen sink so I can only hope Nivolumab helped because when I was in the hospital and could not get my meds my PSA doubles every two weeks (PSA went from 0.7 to 1.7mg/ml over the 14 day in the rehab hospital where I learned to walk again.

Immunotherapy works well when you have a cancer with a lot of Mutations = a hot cancer. PCa is not considered a hot cancer until you have a high gleason or has progressed to an advanced stage. Melanoma (a fast growing cancer as compared early PCa) is often HOT with 50% with BRAF mutations like I have and I have had my PCa for 29+ years starting with Gleason 8, so My PCa with mets could be Hot too with possible protein P10 and P53 loss of Function mutations. Jerry Deans had loss of P53 protective function and another member we lost quickly had P10 loss of Function. For these advanced Prostate cancers mutation, Immunotherapy treatment holds a lot of Promise. At the meeting, I will discuss how I am priming my immunotherapy with food, supplements, exercise and drugs to help my cancer fights. I hope you can come as the immune system can wane with age so we need to do what we can do to strengthen it. The immune system is the best protection we can do for ourselves with the right diet and exercise to keep it strong.

The Google website below for the latest research for treating Advanced P53 and P10 mutated PCa.

Best
Peter

To Go to the Website - Click on the Link Below:

Link 1 : "Immunotherapy"
or Go To
https://www.uchicagomedicine.org/forefront/cancer-articles/personalized-immunotherapy-combination-for-an-aggressive-form-of-advanced-prostate-cancer

New Pathway found to block the failure of ADT drugs to save the lives of many men that die because their ADT treatment fails (like mine has after a few years).

Us Too Warriors,

Check out this website below for positive information on fighting PCa.that applies to the 20% of men who fail ADT (Androgen Deprivation Therapy).
Best
Peter

To Go to the Website - Click on the Link Below:

Link 1 : "ADT"
or Go To
https://www.sbpdiscovery.org/news/new-treatment-approach-for-prostate-cancer-could-stop-resistance-its-tracks#:~:text=New%20treatment%20approach%20for%20prostate%20cancer%20could%20stop%20resistance%20in%20its%20tracks,-February%203%2C%202023&text=For%20the%20first%20time%2C%20researchers,a%20single%20enzyme%2C%20called%20PI5P4K%CE%B1

********************
The value of adding Lycopne to your diet

Us Too Warriors,

My family experience is that my brother who plants many tomatoes that his wife put up so he had them all year long is on active surveillance only while his older brother and I are with advanced prostate cancer. I am going to plant my garden boxes with more tomato plants and Swiss Chard this spring only. Lycopene, the active ingredient in tomatoes, is released only when cooked, especially with olive oil. The Paper attached below indicates you need high doses of lycopene to stop cancers, both PCa and melanoma.

You can buy lycopene supplement pills - mine only contain 40 mg - when you need much higher doses according to the paper below. In the blog, copied from the naval officer, he used two ounces of tomato paste (this has been cooked) in smoothie at breakfast to lower his psa from 1.8 to 0.9. The paper attached lays out research for prostate cancer and melanoma. I am going to have tomato sauce for my Italian dinner tonight. See the following for more details.
Best
Peter

Lycopene - The following is a post from Mike USNA64

After my brachytherapy my PSA start to increase (0.18). I started including tomato paste (high in lycopene) in my morning breakfast smoothie (about 2 oz). My next PSA was 0.09. Will have another PSA in about a month and see what is happening.

To Read the Paper - Click on the Link Below:

Link 1 : "lycopene"
or Go To
http://rvaprostatecancersupport.org/PDF/4 5 23 Multitargeted therapy.pdf

I had to learn to walk again at age 82 after brain surgery for cancer Mets -Video which helps teach balance for walking was helpful See below

Us Too Warriors,

Falls are dangerous at any age but if you have health issues or age then you need to prepare yourself to prevent bodily damage.

See the video on how to help with walking. ( Age or Injury - the Video will keep you from having more injury caused from falls)

I have been learning how to walk all over again after my brain surgery (for nearly 2 months, Feb 7 th 2023). Some of my experience follows.
Best Peter
*
For example, my brother triped last year and tore his tricep muscle out of his elbows that had to be reattached by surgery. A year later after surgery, he has regained a lot of his arm strength to lift/carry weight. I learned from my Navy godfather to hit and roll when you fall, which kept me from smashing my face when running on the road or from falling with a soccer ball. At fifty years old (I only got 6 stitches on my temple from the fall rather than teeth knock out, nose broken and face fractures.)

Recently, when Paralyzed on my left side with a brain tumor, I had 12 falls in a week in my house with only a little bruising before I went to the hospital by ambulance to find out what was wrong. After getting an Axumin Scan (which I requested - this scan was for PCa as the PSMA scans may not have shown the met found in my hip because melanoma does not produce PSMA), that turn up a large met in my hip from a biopsy (drilled into the hip bone) that did not stain for prostate cancer but on restaining with different dye showed it was melanoma. This is why I say I'm glad I had prostate cancer or I would not have found my melanoma cancer and my10 mets.

Keep Smiling Peter

To See the Video - Click on the Link Below:

Link 1 : "Walking"
or Go To
https://www.youtube.com/watch?v=n4pPyE1P74M

Us Too Warriors,

Eight years ago, I bought a Vibration Plate to stand on to help me with my fitness for soccer and work the kinks out of my back if it felt out of sorts. Also found it relieved unbearable cramps in 10 seconds by improving blood flow when I could hardly stand. And now after my brain surgery for melanoma, it has helped me regain my ability to walk from paralysis of my right leg and arm. I drove for the first time yesterday a short distance to my Vitamin C infusion and Walgreens for a D-Tap shot so I can see my new granddaughter.

Google "Gym Sources Vibration plates" for online sources for vibration plates-I paid $99 and it works well.

Following Copied from a prostate cancer blog ==>Some years ago I read that vibration plates were being used to prevent bone loss in the elderly that were unable to exercise. Surprisingly it was also found that standing on a vibration accelerated the healing and recovery of soft tissues.

"I scanned the article. Bone density was what was used as a standard measurement to gauge the effectiveness of the drug. You know about the vibration plates originally developed to prevent bone loss in astronauts on long term periods in space don't you? Us Too warriors - Then, after the astronauts' use of these plates proved their value in preventing bone loss, vibration plates were used for the elderly unable to exercise to prevent bone loss. It was found that the plates not only prevented bone loss but accelerated soft tissue recovery such as when a patient had surgery. Imagine that! Next--the trainers for professional sports teams --such as the NFL--used these plates to hasten recovery of the athletes from workouts and injury! Many players bought their own vibration plates to use at home. Gym Source sold high end vibration plates and Amazon carries quite a selection of vibration plates.

Rather than chance side effects from a drug--buy a vibration plate--uhh--the only side effect will be when one opens their electric bill! Haa! Unfortunately, standing on a vibration plate is still -- a no sweat!"

Best Peter

****
Us Too Warriors,

I will show what I mean for both these cancers.

First for Melanoma, I take these treatments=SBRT radiation to leg, pelvis,spine and brain mets, brain surgery for Met removal, Immunotherapy of "Opdualag" infusion 1/month, High dose 75 gm Vitamin C iv infusion 2/wk (all performed by Doctors and infusion facilities). Then I add my own nano Niclosamide mix in heated(200*c), mixed and shaked in olive oil with pH 9.5 water Plus all the following supplements (Most supplements are design to improve my Immune System to make my Opdualag immunotherapy more effective in killing cancer cells at about 4 pills each per day)

SUPPLEMENTS:
1.Chrysin
2.Lactoferrin
3.Fucoidan
4.Korean red Ginseng
5.Berberine
6.Green Tea
7.Apigenin
8.Curcumin
9. Beta Glucans
10. Gallic Acid
11.Bee Propolis
12.Silibirin
13. Chaga Mushroom, Turkeytail Mushroom
14.Resveratrol
15.Salvia
16.Quercetin

To see how a supplement above treats PCa search Google "Supplement above and Prostate Cancer"
And
To see how a supplement above treats Melanoma search Google "Supplement above and Melanoma"

Prescriptions/treatments for PCa and Melanoma

Also for Prostate Cancer, I take prescription Casodex as Monotherapy of 150 mg/d to block testosterone off cancer cell androgen receptor to stop cancer cell growth {but no Lupron used so I keep my Testosterone between 700 to 900ng (=810ng March15th)] Also Prescriptions of Dutasteride (Avodart) 0.5 mg/d and.Finasteride(Proscar) these 5 mg/d to keep from forming Dihydrotestosterone that forms cancer 10x faster and doxycycline was 100 mg/d for 17yrs for PCa to slow mets forming by stopping MMPs forming on surface cancer spikes that chew thru the extracellular matrix so cells escape in the body to do damage , but i have just increased "Doxy" to 200 mg/d to fight my Melanoma Mets. Metformin prescription of 1500 mg/d to lower blood sugar in fighting cancer growth from sugar even with trying to limit it in Diet especially High fructose corn syrup. Pravastatin prescription of 40 mg/d.also for PCa to lower cancer growth by 38%. It appears from my research that melanoma grows by many of the same factors/pathways as Prostate cancer. For example, Melanoma can have an androgen receptor on its cancer cell in males, so testosterone can grow melanoma if it grows by Zip9 pathway and that is the case, Casodex may block the growth. On the other hand, a recent clinical trial showed that Nivolumab (a major drug component in Opadualag) slows PCa.This is a bonus that many of my treatments for PCa can help with melanoma and many of my treatments Melanoma can help treat PCa. Also, All the supplements numbered above worked for both.PCa and Melanoma.

I Feel Like I Have Been Thrown In the Briar Patch By BRER Cancer FOX ! ! !

********
Us Too Warriors,

RVA Us Too- MY use of IV vitamin C 75gm twice aweek decreased PSA30% when it should have goneup 50%. I am using it to fightmyStage four Melanoma

Melanoma,Grows the same as PCa accelerated by high androgen receptors.See attached paper -I have stage four melanoma with 10 mets 4 in legs , 3in Backbone and 2 in Brain. One in pelvis. I am having 3 radiation sessions to 8 of them, I have had brain surgery and Brain radiation. I can now walk slowly after 12 days of hospital rehab.

I am Thankful FOR for Prostate Cancer as my scan search for PCa mets found the large melanoma met I have in my pelvis. Androgen blockers for PCa fight melanoma and may keep my immunotherapy for melanoma Working.
See paper Below.
BestPeter

To Read the Studies - Click on the Links Below:

Link 1 : "Vit C 1"
or Go To
https://pubmed.ncbi.nlm.nih.gov/12837460/

Link 2 : "Vit C 2"
or Go To
https://www.findinggeniuspodcast.com/podcasts/promiscuous-molecules-jeanne-drisko-explains-the-vitamin-c-for-cancer-connection/

Rva Us Too- Last year in an email I talk how Nicolosamide lowered my PSA in PCa in heated&shaked in olive oil now - papers show it works for melanoma TOO!!!!!
Link 3 : "Nicolosamide 1"
or Go To
https://pubmed.ncbi.nlm.nih.gov/31465777/

Link 4 : "Nicolosamide 2"
or Go To
https://link.springer.com/article/10.1007/s11094-016-1471-5

Us Too Warriors
As many of us have a few years on us which adds to our health
concerns it is good to know how to resist these problems. The attachment describes
how IV Vitamin C can help with many including Brain and neurological problems besides
cancer which it has helped me with.
Best Peter

Link 5 : "Vit C"
or Go To
https://ccimhealth.com/high-dose-iv-vitamin-c-treatment-program/

**************************************************************
Improvement by PROTACs use could improve androgen receptor blocking Therapy in treating PCa and Melanoma Cancers

Us Too Warriors,

If this treatment becomes available it will overcome Androgen receptor blocking failure like my Brother has experienced with Xtandi and I have experienced from Casodex.

And Jerry Deans experienced failures that eventually lead to his Death. See attached Links
Best
Peter

To Read More - Click on the Link Below:

Link 1 : "Improvement 1"
or Go To
https://pubmed.ncbi.nlm.nih.gov/30271980/
*
Link 2 : "Improvement 2"
or Go To
https://www.biorxiv.org/content/10.1101/2022.05.27.493720v1
******
Hi All

Great News - Peter is Home and not in the Hospital.

(The below is a glimpse of Peter's journey.)

Us Too Warriors,

Most of you have known Dr Peter Moon for a long time and the newer folks will also realize he has always worked for the Best Interest of our group.

Peter is in the hospital and once again taken up the battle against Prostate Cance, Bone metastases and now a New Melanoma. When I last talked to Peter, he was still making plans to help the men in our group with information and meetings to better combat their Prostate Cancer.

The Hospital address where you can write Peter a cheerful note is - Henrico Doctor's Hospital /the Forest Campus - “Room 322”/ Att: Dr Peter Moon -1602 Skipwith Road Richmond, VA 23229. Phone - 804-289-4500. (This is in the PNCU location of the Hospital at The Forest Campus.)

André Basmajian has visited Peter and feels his recovery from surgery for his skin cancer and radiation treatments continues to be positive. He has good skin color and plans for the future.

This is your chance to give something back - Take the time and Give Peter a call & let him know just how much his work has helped you. Peter can be reached at 804-387-2151 and if he doesn't answer - he will get back to you when he can - Feel Free to leave a message.

Of Course, Prayers and Best Wishes are always Welcome.

Best
Paul

We have lost a Hero - I Just learned Dr Snuffy Myers Passed away January a year ago

Us Too Warriors,

Many of our Members Benefited from his years of Knowledge of prostate cancer thru his newsletter and Video presentations on all aspects of PCa treatment. Even today I am looking into getting estrogen patches he used to place near my bone mets as a way to get them to heal from a localized increase in estrogen to block my melanoma mets. He would drive over with his wife, Rose, from Charlottesville to speak to our group almost every year from about 2005 to 2016 until Parkinson's disease took its toll on his health. He was a kind and thoughtful man who helped many including me and my brother. He survived his own fight with PCa as I suggest he passed from Parkinson's which was debilitating him even when I last saw him at a meeting at Virginia Beach in 2017.

May He Rest in a Well Deserved Peace.

What follows is my last email from him about a year before he passed and an article he sent me.
Best
Peter

To Read the Email - Click on the Link Below:

Link 1 : "Pain"
or Go To
http://rvaprostatecancersupport.org/PDF/1 16 23 Dr Meyers.pdf

Low testosterone in men increases death from Covid (Estrogen protects against melanoma for women)

Us Too Warriors,

In my search for treating my Melanoma - I found this statement about Covid deaths and low Testosterone.

Testosterone Interacts with the Immune System

While Testosterone is most strongly associated with virility and muscle development, the masculine hormone is intricately involved in various functional processes. This can lead to varied and unexpected differences between men and women when it comes to effective treatment. For example, the influence of Testosterone significantly impacts the effects of Covid-19 on the immune system. Low Testosterone puts men at increased risk of severe complications and death caused by the disease (Covid).
Best
Peter

To Read More - Click on the Link Below:

Link 1 : "(Link)"
or Go To
https://www.testosterone.me/blocking-testosterone-to-defeat-melanoma

More information about an imunnotherapy for PCa from a Member who benefited for clinical trial

Us Too Warriors,

This is from a member of our group==>"For prostate cancer patients, keep Enoblituzumab on your radar screen. I participated in a clinical trial at Johns Hopkins, Sidney Kimmel cancer center, and received this immunotherapy agent prior to surgery and was one of 7 patients that had the desired response. Sometime later, I heard of a patient who had had his prostate removed, he had an undetectable PSA, but it had metastasized. He read about the study I participated in and approached Johns Hopkins. They constructed an N-1 study for adjuvant treatment for him and at the time of the article, which was published by Johns Hopkins, he was undetectable, and the metastases had all but disappeared.
Best
Peter

To Read More - Click on the Link Below:

Link 1 : "(Imunnotherapy)"
or Go To
https://www.onclive.com/view/early-data-make-b7-h3-a-checkpoint-contender-in-prostate-cancer-and-beyond

Treatment from a Blog on Mets to spine causing Pain and possible treatment

Us Too Warriors,

I have just completed SBRT treatment to 3 spine Vertebrae, I have no pain yet but to be proactive I have found and ordered an enzyme to prevent pain. I know Jerry Dean suffered Bad pain in his back near the end. Blog below describes this treatment. It is called "Serrapeptase" available w/o prescription on Amazon.
Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "Pain"
or Go To
http://rvaprostatecancersupport.org/PDF/1 14 23 Mets to the spine.pdf

Bone health is important for PCa and also for the Brain Function with age

Us Too Warriors,

Years ago I first reported on a startling discovery – one of the most important factors that keeps your brain healthy and your memory intact is a hormone released by your bones.

And unless you can support your bones in their task of supplying the brain with this vitally important natural chemical called osteocalcin, your memory will almost certainly fracture.

Even though the studies of osteocalcin haven’t been as widely reported as they should have been, researchers have been proceeding full throttle to better understand how this hormone influences the health of your brain and other organs.

Medical folks once believed that your bones mostly function as a structural support system for your body, kind of like beams in a house. However, a new investigation into hormones released by bone tissue have them rethinking that view.

And some of the most surprising findings have centered on how osteocalcin released by the bones affects the brain.
Best
Peter

Necessary for Brain Function

As researchers at Columbia University have noted, their lab tests on animals reveal “a remarkable, totally unexpected aspect of the bone-derived hormone osteocalcin is that it is necessary for both brain development and brain function.”1

To Read the Info - Click on the Link Below:

Link 1 : "(Brain Function)"
or Go To
https://awakeningfromalzheimers.com/want-a-healthy-brain-look-to-your-bones/

Immunotherapy is starting to make a splash in treatng Prostates cancer (PCa)

Us Too Warriors,

It looks as if Immunotherapy is starting to Impact on PCa. Look up papers below for more informations - These are the first I have seen.

I expect to have speaker in the near future if covid sub sides to speak about his great results from a clincal trial with Nivolamab immunotherapy. I am getting this therapy soon for my melanoma and hope it helps my PCa.

Usually prostate cancer is considered a "cold" cancer that does not lightup the immune system but if you have the right mutations it seems to work well.
Best
Peter

Abstract

Background:
CheckMate 9KD (NCT03338790) is a non-randomized, multicohort, phase 2 trial of nivolumab plus other anticancer treatments for metastatic castration-resistant prostate cancer (mCRPC). We report results from cohorts A1 and A2 of CheckMate 9KD, specifically evaluating nivolumab plus rucaparib.

To Read the Info - Click on the Link Below:

Link 1 : "(Immunotherapy 1)"
or Go To
https://pubmed.ncbi.nlm.nih.gov/35977756/
*
Abstract

Background:
Docetaxel has immunostimulatory effects that may promote an immunoresponsive prostate tumour microenvironment, providing a rationale for combination with nivolumab (programmed death-1 inhibitor) for metastatic castration-resistant prostate cancer (mCRPC).

Link 2 : "(Immunotherapy 2)"
or Go To
https://pubmed.ncbi.nlm.nih.gov/34802864/

Drinking enough water to lower sodium below the Middle range of normal range, but not below normal to add years to your Life

Us Too Warriors,

The importance of drinking enough water was recently Printed online to dilute your Sodium level so you live longer See below Middle-age high normal serum sodium as a risk factor for accelerated biological aging, chronic diseases, and premature mortality
Open Acces - Published:January 02, 2023 - DOI:https://doi.org/10.1016/j.ebiom.2022.104404
Best
Peter

Summary

Background

It is known that some people age faster than others, some people live into old age disease-free, while others develop age-related chronic diseases. With a rapidly aging population and an emerging chronic diseases epidemic, finding mechanisms and implementing preventive measures that could slow down the aging process has become a new challenge for biomedical research and public health. In mice, lifelong water restriction shortens the lifespan and promotes degenerative changes. Here, we test the hypothesis that optimal hydration may slow down the aging process in humans.

To Read the Info - Click on the Link Below:

Link 1 : "(Drinking Enough Water)"
or Go To
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00586-2/fulltext

Website with some Free courses that may help you fight your cancer

Us Too Warriors,

Look at the courses available at this website to see if they float your boat. I will be taking a course onImmunology from Rice University for free.

Best
Peter

Fundamentals of Immunology Specialization

Learn basic concepts and vocabulary in immunology!. Analyze new developments in immunological therapies designed for the treatment of disease.

To Read the Info - Click on the Link Below:

Link 1 : "(Free Courses)"
or Go To
https://www.coursera.org/specializations/immunology?recoOrder=0&sfmc_id=110714670&sfmc_key=0038W00001l2EfSQAU

IMMUNNE CHECKPOINT INHIBITOR (ICI) cancer treatment affect on Covid deaths Paper follows. I will start this treatment Jan 4th

Us Too Warriors,

The following information explains why I require Masks and distancing at Meetings.

Clinical impact of COVID-19 on patients with cancer treated with immune checkpoint inhibition - paper title==>

Findings Thirty-five (32%) patients were admitted to hospital and 18 (16%) died. All patients who died had advanced cancer, and only four were admitted to ICU. COVID-19 was the primary cause of death in 8 (7%) patients. Factors independently associated with an increased risk for hospital admission were ECOG ≥2 (OR 39.25, 95% CI 4.17 to 369.2, p=0.0013), treatment with combination ICI (OR 5.68, 95% CI 1.58 to 20.36, p=0.0273) and presence of COVID-19 symptoms (OR 5.30, 95% CI 1.57 to 17.89, p=0.0073). Seventy-six (73%) patients interrupted ICI due to SARS-CoV-2 infection, 43 (57%) of whom had resumed at data cut-off.

Website below is the source of the cancer rate below in cancer Patients.
Mortality rates of COVID-19 infection in the cancer population range from 7.6% to 33%5–9 compared with 1.4%–2.3%3 10 in an unselected population.

Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "(ICI)"
or Go To
https://jitc.bmj.com/content/9/1/e001931

"A new tool in my bag to Fight Prostate and Melanoma - Combination of " IV Vitamin C, Doxycycline and Niclosamide"

Us Too Warriors,

With only High IV Dose Vitamin C use (~50 grams at least twice a week), analysis of PCa treatment shows that it does not lower PSA but that it increases the doubling time which can add more days to your life which I hope to do as my doubling time over the 2 I/2 years usually has been between 3 to 5 months except for a 4 month period when niclosamide stopped it from doubling and dropped it 10%. My present plan is to add IV vitamin C and Niclosamide to my immunotherapy and in future to consider adding Doxycycline which I had used for years but recently stopped because of concern it might affect my gut biome bacteria so as to make my immune system less strong. I will reconsider the use of doxycycline after I see how the Immunotherapy is working???

The paper attached below discusses how this off label use of these drugs can reduce cancer growth by attacking Cancer stem cells.

Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "Combination"
or Go To
https://pubmed.ncbi.nlm.nih.gov/28978032/

*
This video discusses good test to see if you need Biopsy by a urologist I put Dr. Androiles on the same level with Dr. Snuffy Meyers.

Us Too Warriors,

When I went to Dr Gerald Androiles website recently I found he had over 800 papers. One of the papers in1996 recommended use of drugs like proscar and avodart as soon as you had biochemical recurrence before the PSA was above 1.0 (started at a PSA=0.3 in the year 2000). You can keep your PSA from rising fast above 1.0 before it takes off (by using these drugs to block Dihydrotestosterone = DHT). It stopped my PSA at <1.0 for 14 years and has added at least 16 years to my life. I think if you are looking at getting Biopsies this is worth looking at.

Today's progress update==> I had a port for immunotherapy put in my chest, I got Vitamin C IV approved, I am scheduled for more SBRT of my back and legs, but legs are hard to treat. I start immunotherapy Jan 4 th. The herds of cats are going in the right direction finally.

Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "Benefits of MRI Fusion Biopsies"
or Go To
https://www.youtube.com/watch?v=5epKvek95aY

*

Link 2 : "Biopsy"
or Go To
https://grandroundsinurology.com/prostate-cancer-screening-what-we-learned/

***************************************
Radiation for Bone Metastases May Improve Cancer Survival- This is why I am having SBRT w/ Dr Cuttino at Henrico Dr. Hospital Forest

Us Too Warriors,

You may want to file this website below away in case your cancer produces bone Metastasis. My prostate cancer did but I seem to beat it with all I do and Casodex over the last 5 years. But In the last Six months the Melanoma has come on with a vengeance to produce 7 bone mets spots. Bone mets in melanoma are much more unusual compared with Prostate cancer. Bone mets only occur in 4% of the people with melanoma so there is not a lot of research on their treatment.
I think this website to follow is good as it gets in supporting radiation treatment for bone mets.

Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "Link"
or Go To
https://www.medpagetoday.com/meetingcoverage/astro/101436?xid=nl_mpt_SR_specialty_update_2022-11-11&eun=g2139714d0r

*
The connections between Prostate cancer and Melanoma I have discovered in my research !

Us Too Warriors,

Some of my research discoveries follow:

1. Having your face breakout with pimples as a teenager will make you more likely to have prostate cancer and melanoma as you age. Hormone imbalance.
2. Getting Prostate cancer early, like less than 60 years old is more likely to make you more prone to melanoma as you age.
3. More androgen receptors grow both PCa and Melanoma.
4. Androgen receptor blockers like Casodex, Xtandi, Apalutamide slow both melanoma and PCa. But with PCa these drugs eventually make you castration resistant which occurred in my case after 2 1/2 years and most men by 5 years which is not good as this makes surviving hard.
5. Zinc supplement helps fight PCa but it grows melanoma .
6. Low dose doxycycline(100mg/day) stops spread of PCa but makes melanoma more likely to grow by reducing gut bacteria needed to promote the immune system.
7. Estrogen may grow breasts in PCa when on Androgen receptor blockers that make breast hurt when bumped which can be prevented with aromatase blockers which keep testosterone from breaking down into estrogen that cause the breast problems but estrogen is good to stop melanoma (versus testosterone) as women with melanoma only die 1/3 as often from melanoma versus men with melanoma.

I am trying to find ways to promote my gut biome for my immune system, increase my estrogen, reduce my androgen receptors so I have stopped Femara that blocks my testosterone becoming estrogen. I have stopped my Doxycycline to increase my gut biome. I stopped zinc to slow melanoma growth through the Zip9 pathway. These changes will affect my PCa growth adversely which I have to follow closely too. My Casodex which blocked androgen receptors (no longer working after 5years for PCa) but now taking it to do the same for melanoma.
I am looking for supplements that slow melanoma growth now and stop ones that might promote its growth. It is a tightrope to walk between these cancers.

I will soon start a new round of SBRT radiation for 5 new spots found from the FDG Pet scan for melanoma on both legs and spine T10 & 11. My previous SBRT treated my left pelvis and spine L3 from my earlier Axumin scan for PCa. I will add Immunotherapy (Opdualag) & IV high dose Vitamin C.
It looks like a fun and exciting year Ha Ha. He, He - Best Wishes for Your Healthy New Year. Peter
I am working with 8 Doctors to manage all my treatments - More fun than herding cats!!!

Best
Peter

*
We detected price drops at Life Extension and an update on C-reactive protein Test!!

Us Too Warriors,

I want you to be aware of the cost savings over the next 24 hours From Life extension supplements that along with Swanson Supplements have served me well in my battle with PCa. For example, My sign for inflammation, C-reactive protein, was extremely low at 0.5 in December 2021 which is amazingly low but after my Melanoma progress in December 2022 it is 17.11!!!, Dangerously high if above 10; But best for your heart if below 3.0

The inflammation in Dec.2022 is from melanoma rapid progression. On Checking my supplements and drugs, I found that ZincCitrate which fights PCa grows Melanoma, as does the drug Femara I had been using to block painful and enlarged breasts from AR blocker Casodex to keep testosterone from breaking down into estrogen. But estrogen protects against melanoma as 1/3 of women die of melanoma with their estrogen than men. Also, I have stopped/reduced my low doxycycline (100mg/day that blocks MMPs and thus PCa from spreading). More varied bacterial gut biome improves the immune system ( I will be starting immunotherapy soon and will add probiotics to aid my immune system.) If you do not have any melanoma you can keep using these supplements.

PS

New Pet scan shows I will need more SBRT after Christmas in both legs and T10 & T11 in my spine as I expected from my reading. I will follow this with high dose IV vitamin C, 50gm, at least twice a week and Immunotherapy once a month through an injection port.

Keep smiling, Merry Christmas, Life is Good,

Best
Peter

*
Secondary cancers associated with Prostate cancer

Us Too Warriors,

This is designed to give you warning that there have been some cancers found to be associated with prostate cancer. I have seen that in my case Melanoma may occur at 20% rate in conjunction with prostate cancer . But,I am particularly vulnerable because I have a red hair gene that makes it 8x times more likely. This web site to follow gives other cancers to be vigilant to detect along with your Prostate cancer. In fact, I found my melanoma Metastasis when searching with a pet scan for prostate cancer metastasis progression.

Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "Link"
or Go To
https://www.cancer.org/cancer/prostate-cancer/after-treatment/second-cancers.html

*
Video w/Dr Demeade on Bi Polar Hormone therapy for men on ADT to treat their cancer if they do not have pain to improve quality of life

Us Too Warriors,

This may be a way to help about 1/3 of the men on Hormone therapy without pain but it is not for all.

Best
Peter

Samuel Denmeade, Co-Director of the Johns Hopkins Prostate Cancer Program joins Alicia Morgans in a discussion on Bipolar Androgen Therapy (BAT) for prostate cancer. ADT slows prostate cancer’s progress by shutting off testosterone. Eventually, cancer adapts to this new environment and PSA levels start to rise. The concept of BAT is for men whose prostate cancer has become resistant to standard hormone-blocking therapy. The pair discuss the ideal patient population for this treatment and its benefits suggesting that the physical vitality of patients could be maintained on BAT.

To Read the Info - Click on the Link Below:

Link 1 : "Link"
or Go To
https://www.urotoday.com/video-lectures/pcf-2022/video/mediaitem/2959-bipolar-androgen-therapy-in-the-management-of-prostate-cancer-samuel-denmeade.html

*
Pod cast of the use of IV Vitamin C for advanced cancers Treatment

Us Too Warriors,

This podcast does not discuss IV Vitamin C uses in Prostate cancer but does describe its action in Chemotherapy in some cancers making treatment more effective and reducing side effects. There is still a lot more to learn but this is a good foundation discussion.

Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "Pod Cast"
or Go To
https://www.findinggeniuspodcast.com/podcasts/promiscuous-molecules-jeanne-drisko-explains-the-vitamin-c-for-cancer-connection/

*
Blog on Discusson of Leakage after PCa surgery and years later

Us Too Warriors,

If you are dealing with incontinence the website below may help. It seems normal to have some stress incontinence that may be made worse by excess water and alcohol, etc.

Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "Blog"
or Go To
https://www.inspire.com/groups/zero-prostate-cancer/discussion/incontinence-long-after-prostatectomy/?dderh=218d4627157bf6a9995654341fd4764d

*
Blog on pain management in men with Advanced Prostate cancer

Us Too Warriors,

I have copied below the response of men dealing with Pain management in advanced Prostate cancer. This is a concern if cancer progresses. SBRT radiation can help and there are many avenues of drug & supplement treatment. It is important to find what works for you without causing other problems.

Nsaids can be a problem if used long or high doses. It help kill my wife after 32 years of Pain. CBD oil and marijuana can help and are being recognized as beneficial. For Now CBD oil and heating pad and movement are adequate for me. I hope what follows will help you manage if you have need. Have A blessed Christmas and New Year.

Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "Blog"
or Go To
http://rvaprostatecancersupport.org/PDF/12 13 22 pain management.pdf

*
Jane McLellan Storey-How She Starve her cancer & My story fighting Prostate cancer w/off label Drugs, Supplemeents & diet is simular

Us Too Warriors,

See the website to find out more that follows and I too depended on Life Extension magazine(Free) for new ammunition besides google research articles to fuel my PCa treatment (28 years). I use some of the same off label drugs (doxycycline and metformin etc). I am now doing the same to fight my Stage 4 melanoma. I will be using high dose IV Vitamin C as She has if I qualify after my blood tests this week. Look at the website below to get the flavor of this Process All the best for for your fight and the holidays

Best
Peter

Against All Odds

Jane McLelland beat cervical, lung, and blood cancers using the missing link to defeat cancer: starving it. She is partnering with Life Extension® to help other patients achieve the same results.

Scientifically reviewed by Dr. Gary Gonzalez, MD, in May 2022. Written by: Laurie Mathena.

Link 1 : "Website"
or Go To
https://www.lifeextension.com/magazine/2020/1/wellness-profile

*
Bone cement to strenghten Bone Mets - I wll be seeing an orthopedist at VCU to see if this would strengthen backbone & Hip mets

Us Too Warriors,

In my 28 years fighting cancer, I had not heard of the use of Bone cement used for treatment prostate cancer but when I contacted a VCU doctor to review my body scans of melanoma he referred me to an Orthopedist doctor in January for bone cement treatment to my mets. After I see him I will report what I find. For now I have attached a paper with some information to use. It appears bone cement can be used in three ways.- 1. as a strengthening of the weakened bone from metastasis or 2. as source medication to kill the cancer in the bone or 3. for both purposes.

Abstract

Metastatic bone lesions are common among patients with advanced cancers. While chemotherapy and radiotherapy may be prescribed immediately after diagnosis, the majority of severe metastatic bone lesions are treated by reconstructive surgery, which, in some cases, is followed by postoperative radiotherapy or chemotherapy. However, despite recent advancements in orthopedic surgery, patients undergoing reconstruction still have the risk of developing severe complications such as tumor recurrence and reconstruction failure. This has led to the introduction and evaluation of poly (methyl methacrylate) and inorganic bone cements as local carriers for chemotherapeutic drugs (usually, antineoplastic drugs (ANPDs)). The present work is a critical review of the literature on the potential use of these cements in orthopedic oncology. While several studies have demonstrated the benefits of providing high local drug concentrations while minimizing systemic side effects, only six studies have been conducted to assess the local toxic effect of these drug-loaded cements and they all reported negative effects on healthy bone structure. These findings do not close the door on chemotherapeutic bone cements; rather, they should assist in materials selection when designing future materials for the treatment of metastatic bone disease.

Link 1 : "Website"
or Go To
https://pubmed.ncbi.nlm.nih.gov/33552885/

*
This website seems to provide new research For Prostate cancer. Check it out.

Us Too Warriors,

Check this website to find out more below.

Dr. Laura Sena discusses ongoing trials of bipolar androgen therapy in prostate cancer December 5, 2022 - Urology Times staff

Link 1 : "Website"
or Go To
https://www.urologytimes.com/view/dr-laura-sena-discusses-ongoing-trials-of-bipolar-androgen-therapy-in-prostate-cancer

*
No December meeting Enjoy your Holiday and All the best in the new year.

Us Too Warriors,

I hope the end of the year finds you in Good spirits and ready to take on the challenges of the new year. I am starting my SBRT treatment for melanoma bone metastasis in the left hip. I am heating the area with 6500 and 8500 infrared Light. The heat from the light is soothing and I hope it aids my immune system. I am adding high dose Vitamin C IV to improve the immune system and move some of the blood enzymes for both prostate and melanoma cancers in the right Direction. I expect that the Vitamin C IV will help both Melanoma and Prostate cancer so I will get two bangs for my BUCK.

I hope we will have a Us Too Prostate meeting on Jan19 th at 2 PM. I am looking for volunteers to run Meetings in the future. If you have any questions about your treatments for PCa you want to run by me? Please call my cell phone 804-387-2151.

An analysis from the phase 3 SAKK 09/10 trial presented at the 2022 ASTRO Annual Meeting showed that PORTOS, an expression signature of 24 DNA damage repair and immune pathway genes, has the potential to predict which patients will benefit from dose-intensified salvage radiotherapy (SRT) after radical prostatectomy.1,2

All the Best Peter

PS. I have to be thankful I have prostate cancer because when using a pet scan to look for Prostate cancer Metastasis, I found the Melanoma metastasis.
We Live in a strange world .

*
Portos Decipher TEST of 24 Genes shows men who benefit from Increased radiation Dose after BioChemical recurrrence after surgery

Us Too Warriors,

Check this website to find out more below.

Hope you had Healthy Thanksgiving

An analysis from the phase 3 SAKK 09/10 trial presented at the 2022 ASTRO Annual Meeting showed that PORTOS, an expression signature of 24 DNA damage repair and immune pathway genes, has the potential to predict which patients will benefit from dose-intensified salvage radiotherapy (SRT) after radical prostatectomy.1,2

Link 1 : "Website"
or Go To
https://www.urologytimes.com/view/molecular-signature-predicts-response-to-dose-intensified-salvage-radiotherapy-after-rp

*********************************************
Flash lower dose Proton beam treatment trial for Bone Pain from PCa Metastasis- Promising

Us Too Warriors,

Bone Pain is a big down side of PCa Metastasis which I saw Jerry Dean suffer so any improvement in its treatment is a blessing for people with cancer. This proton beam treatment looks to help. I am not sure how much better it is for pain then SBRT radiation - like the Gamma Knife but it is only the clinical stage now so we will need more information.

Bone Metastases Treated in a FLASH: One Dose of Proton RT

These patients had up to three painful bone metastases in their extremities, but no lesions in the hands, feet, or wrists. They were also required to have a life expectancy of more than 2 months.

There were five male and five female participants, and the median age was 63 years. All of the patients were white, non-Hispanic, and they had a range of primary histologies, including lung, breast, prostate, and thyroid cancer, and multiple myeloma.

Link 1 : "Bone Pain"
or Go To
https://www.medscape.com/viewarticle/982952?src=mkm_ret_221113_mscpmrk_BC_monthly&uac=318354AK&impID=4853207#vp_2

*********************************************
Filtering blood to remove Circulating Tumor Cell is Being developed to prevent Metastasis with CRPC and other cancers

Us Too Warriors,

The future may allow filtering of blood to treat many cancers including prostate cancer- early study looks promising. See the following website !!!

Link 1 : "Filtering Blood"
or Go To
https://extheramedical.com/extracorporeal-blood-filter-removes-circulating-tumor-cells-dialysis-like-cell-removal-therapy-to-be-studied-for-treating-metastatic-cancer/

*
Cigna Insurance STINKS as they will not pay for PET Scans for advanced cancer

Us Too Warriors,

If you have advanced prostate cancer with rising or Metastasis, You need a pet scan to find its extent so you can treat it best.

Cigna's rules do not allow pet scans and also if you need the latest FDA treatment you have to have a pet scan to show you have PSMA on the surface of your cancer cells to qualify for the Lu177 treatment. So if you have Prostate cancer you need to check your insurance rules to see what imaging your insurance will pay for. If you can not find (Image) your cancer you can not treat it.

*
The Opdivo (Nivolumab) and Yervoy (Ipilimumab), My treatment for Melanoma, is reported in paper attached for mCRPC

Us Too Warriors,

The paper attached below suggests my selected treatment for Melanoma may help with prostate cancer 22% of the time ( if I have the time if I have the right mutations which I do not expect I have). But it also describes the possible side effects of treatment which I may start in December. I do not expect to have a meeting in December - But I will try to keep all informed on developments in PCa and Melanoma best I can. So please reach out to me about any concerns you have about your progress and treatment.

Link 1 : "Selected Treatment"
or Go To
https://pubmed.ncbi.nlm.nih.gov/32916128/

*******************************************
Liquid blood biopsy for prostate and other cancer comercially available

Us Too Warriors,

This website may provide you with information on a test your Doctor can have run to help guide your treatment.

What is the CELLSEARCH® Circulating Tumor Cell (CTC) Test?

The CELLSEARCH® CTC Test is a simple, actionable blood test that helps oncologists assess the prognosis of patients with metastatic breast, prostate*, or colorectal cancer.

The CELLSEARCH® CTC Test is:

The first and only clinically validated, FDA-cleared blood test for enumerating circulating tumor cells (CTCs). CTCs are cancer cells that detach from a primary tumor and travel through the bloodstream or lymphatic system to other parts of the body.
A “liquid biopsy” that can be used at any time during a patient's course of disease.
Performed at a reference laboratory and processed using the CELLSEARCH® Circulating Tumor Cell System

Link 1 : "Liquid blood biopsy"
or Go To
https://www.cellsearchctc.com/about-cellsearch/what-is-cellsearch-ctc-test#:~:text=The%20CELLSEARCH%C2%AE%20CTC%20Test%20is%20a%20simple%2C%20actionable%20blood,circulating%20tumor%20cells%20(CTCs)

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My fellow Members it looks as if I am in for rought ride with Likely neuroendocrine prostate cancer

Us Too Warriors,

I have attached a paper to give you a flavor of this form of prostate cancer that will occur in 15 to 20% of men that become Hormone refractory if they are on ADT for long periods of time. I have been treating PCa for 28 years as of NOV 15th,1994 so I qualify as a long time treater but only on ADT for ~5 years.

I am attaching a paper below which will give you a flavor of what you have to figure out as of now of how to pick possible treatments. This is not a very straight or clear path. I hope I will know more for our next meeting at 2 PM on Nov 17 th. I hope as I travel down this path I can learn ways to help others that follow this path after me.Best Peter

Abstract

Lineage plasticity and histologic transformation to small cell neuroendocrine prostate cancer (NEPC) is an increasingly recognized mechanism of treatment resistance in advanced prostate cancer. This is associated with aggressive clinical features and poor prognosis. Recent work has identified genomic, epigenomic, and transcriptome changes that distinguish NEPC from prostate adenocarcinoma, pointing to new mechanisms and therapeutic targets. Treatment-related NEPC arises clonally from prostate adenocarcinoma during the course of disease progression, retaining early genomic events and acquiring new molecular features that lead to tumor proliferation independent of androgen receptor activity, and ultimately demonstrating a lineage switch from a luminal prostate cancer phenotype to a small cell neuroendocrine carcinoma. Identifying the subset of prostate tumors most vulnerable to lineage plasticity and developing strategies for earlier detection and intervention for patients with NEPC may ultimately improve prognosis. Clinical trials focused on drug targeting of the lineage plasticity process and/or NEPC will require careful patient selection. Here, we review emerging targets and discuss biomarker considerations that may be informative for the design of future clinical studies.

To go to the Article - Click on the Link Below:

Link 1 : "Therapy Considerations"
or Go To
https://pubmed.ncbi.nlm.nih.gov/34111024/

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Cancer - Table of the two names for each prostate cancer drug

Us Too Warriors,

The below table may be useful.

Best Peter

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Photo Dynamic Therapy (PDT) in place of Active surveillance for low threat cancers-Available in Europe and Mexico- USA soon???

Us Too Warriors,

PDT looks promising in reducing progression that can occur during active surveillance. See the following Article for details.

Best Peter

To go to the Article - Click on the Link Below:

Link 1 : "Photo Dynamic Therapy"
or Go To
http://rvaprostatecancersupport.org/PDF/10 31 22 PHOTODYNAMIC THERAPY.pdf

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Dr Bulsic (NIH/speaker at meetings in 2018-2019) found Metformin lowers PSA in 40% of men with T2Diabetes

Us Too Warriors,

I have taken 1500 mg/d of metformin for several years to fight my PCa. If you take metformin you should also take CoQ10 to keep you muscles from hurting as metformin tends to reduce this in your muscles that can make them painful. I do not have diabetes but I think it helps limit my blood sugar to about 80 to 90 Glucose Units (?). You want your glucose to be less than 100 but if it goes below 70 it can cause one to black out.

Best Peter

To go to the Article - Click on the Link Below:

Link 1 : "Article"
or Go To
https://pubmed.ncbi.nlm.nih.gov/33562646/
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Lupron is not only Bad for your health compared to the Oryvix pill - It is way more expensive at $38,000 per shot

Us Too Warriors,

If you are getting Lupron shots to block your testosterone, you should switch to ORYVIX pills which are not bad for your heart as lupron is!!! By my not going on Lupron in the year 2000 when I had biochemical recurrence of my cancer I have saved the government $1,500,000 and myself $$$$ and 44 shots. Also, a recent ultrasound heart test in the hospital showed no blockage of heart arteries! See the website below for more information.

Best Peter

To go to the Website - Click on the Link Below:

Link 1 : "Lupron Shot vs Oryvix Pill"
or Go To
https://www.npr.org/sections/health-shots/2022/10/26/1131130875/it-cost-38-398-for-a-single-shot-of-a-very-old-cancer-drug
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How fat contributes to Prostate cancer growth.

Us Too Warriors,

I accompanied my Brother to See Dr Meyers in C'ville, Va about 2014 after many years trying to get him to stop eating bacon to no avail.

AS we were finishing the visit I told on his eating of bacon. Dr. Meyers was very nice about how he replied that he grew up in Pennsylvania Ducth country and ate all the pig stuff growing up. To which my brother replied isn't pork the other white meat? ! Doctor Meyers' answer was "NO" (you have to be careful about how you fall for food advertisements). See the Website below -About Fat like Bacon or chicken fat and skin.

Best Peter

To Read More - Click on the Links Below:

Link 1 : "Fat"
or Go To
https://news.weill.cornell.edu/news/2019/11/high-fat-diet-contributes-to-prostate-cancer-progression#:~:text=%E2%80%9CA%20high%2Dfat%20diet%20causes,cancer%20lethality%2C%E2%80%9D%20said%20Dr
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One of our members, Chris, had 50% drop in his PSA from1 1.4 to 0.7ng/ml using 3 supplements

Us Too Warriors,

The 3 supplements were Capsaicin, CBD oil and Curcumin. Below you will find some papers supporting these supplements for a slowing of PSA.

I am ordering Capsaicin today called "Cayenne "by Nature's Way from Swanson, I have some CBD oil my wife used for her Fibromyalgia pain and I have ordered more from Swanson. I have been taking Super Bio Curcumin for at least 17 years from Life extension and I am going to increase my 5 pills a day of life extensions 10 + pills, I used to take 15 a day. Now, my PSA is rising, I will be trying these agents to slow its rise. You may want to consider it too if your PSA is rising.

Best Peter

To Read More - Click on the Links Below:

Link 1 : "Capsaicin"
or Go To
https://pubmed.ncbi.nlm.nih.gov/20174488/
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Link 2 : "Non-THC cannabinoids inhibit prostate carcinoma growth"
or Go To
https://pubmed.ncbi.nlm.nih.gov/22594963/

Link 3 : "Curcumin against Prostate Cancer: Current Evidence "
or Go To
https://pubmed.ncbi.nlm.nih.gov/33182828/
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Protac ARV-110 Clinical trial availble in Charlotsville (& 53 0ther sites).To qualify need mCRPC with several advanced treatments.

Us Too Warriors,

Check out the information attached below if you have mCRPC.

Best Peter

To See More - Go to the Website - Click on the Link Below:

Link 1 : "Website"
or Go To
https://clinicaltrials.gov/ct2/show/NCT03888612

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New Treatment for PCa in the works called "Protacs" - looks to have wide application - in phase 2 studies

Us Too Warriors,

This treatment may help many with advanced PCa - I hope it is available Soon and meets its promise.

Best Peter

OUTLOOK - 14 September 2022

The destructive power of PROTACs could tackle prostate cancer
Drugs that direct the body’s proteolytic capabilities towards cancer cells might overcome problems of treatment resistance.

Best
Peter

To See More - Go to the Website - Click on the Link Below:

Link 1 : "Website"
or Go To
https://www.nature.com/collections/ebebjdddab

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Pylarify Pet scan approved for detection OF Biochem recurrence and Mets for mCRPC progression Jan. 2022 website

Us Too Warriors,

I am getting Pylarify pet scan at Henrico Hospital Forest next week, The website for the scan procedure is Below==>

I am using it to see where my cancer is and how it has changed since December 2017 from an AXUMIN scan then.

I plan to use the scan to make plans for treatment over the next 6 months which may be something like this:

1. DO SBRT treatment to the mets with Dr. Cuttino at Henrico Hospital Forest.
2. Take Scan to a new Dr. I have contacted John Hopkins to get his recommendation and hope to get an ARV-7 Blood test.
2. Get Provenge immunotherapy treatment with Local Dr. while PSA is low for better results this Fall?
3, Get Chemo next year ( Docetaxel and Cabazitaxel) if the test shows I am ARV7 positive or not ( Said to be less of problem than Lupron & Xtandi)
4, Get Ice cap from amazon to keep hair, water ice buckets for feet to prevent neuropathy and ICe chips for mouth to protect salivary glands against dry mouth to prevent chemo side effects.

Best
Peter

To Sign Up Go to the Website - Click on the Link Below:

Link 1 : "Website"
or Go To
https://lantheusholdings.gcs-web.com/news-releases/news-release-details/lantheus-announces-cms-grants-transitional-pass-through-payment

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Us Too Warriors,
Webinar On "Precision treatment of PCa" from Sept 22-24th Free need to register

Us Too Warriors,

As you should know Sept. Is PCa awareness month so a lot of Good Videos/Meetings are available free to help you with treatment - I hope you will take advantage to make you informed to get better treatment. Go To the last of the sign up list to get it for free. I think this one is very Good so I hope you will sign up and take part.

Best
Peter

To Sign Up Go to the Website - Click on the Link Below:

Link 1 : "Website"
or Go To
https://www.eventbrite.com/e/sixth-global-summit-on-precision-diagnosis-and-treatment-of-prostate-cancer-tickets-203294277657?aff=erelexpmlt

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Us Too Warriors,
Recent Paper ("Dietary flavonoids as cancer-preventive and therapeutic biofactors"2021) gives hope on helping yourself.

Us Too Warriors,

As most of you know I try to stay ahead of the enemy with my research into PCa. For example, I have found references to these supplements Quercetin, Resveratrol, Thunder God Vine, and Evodia as fighting ARV7 positive Testosterone spline mutation cancer that I hope to get test at John Hopkins in Two weeks and that my Niclosamide self mix has been stopping. AS you might suspect, I have added these supplements to my niclosamide mix. Other supplements I highly recommend are Apigenin and Berberine to fight PCa. If you find supplements that block HSP90 ( heat shock protein 90) you are on the right track to fight PCa. I have included a website below that can help you find supplements to fight PCa.

Best
Peter

To Sign Up Go to the Website - Click on the Link Below:

Link 1 : "Website"
or Go To
https://www.imrpress.com/journal/FBS/3/4/10.2741/229

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Us Too Warriors,
"PCRI Conference Sept 10 -11 -sign up - starts about 11 am to the rest of the day- Pick Talks Important to you"

Us Too Warriors,

Do Not miss the chance to pick out the topics that are important to you in this conference. I went to my first and only in person PCRI Conference in 2006 with my brother, Don and Jerry Dean in Washington DC. Dr. Snuffy Meyers supported the cost of bringing it to DC - I think it Cost him $20,000 to support it. You can see it for free online by signing up.

Best
Peter

To Sign Up Go to the Website - Click on the Link Below:

Link 1 : "Sign Up"
or Go To
https://pcri.org/2022-conference

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Us Too Warriors,
All cardiac Deaths on ADT (Lupron) was 4.78X higher than men with PCa of age 70 to 79 website Link Below"

Us Too Warriors,
This is another reason I have been avoiding Lupton etc for 28 years, If you are on Lupron you need to have a cardiologist do everything to protect your heart. Remember your heart is a muscle and Lupron among its many faults is it causes muscle loss and also the weight gain that it induces is hard on the heart. Exercise is harder to do from fatigue but it is one of the few actions that helps

Best
Peter

FRIDAY, July 29, 2022 (HealthDay News) -- For patients with prostate cancer, use of androgen-deprivation therapy (ADT) is associated with an increased risk for cardiovascular disease (CVD) death, according to a study published online July 26 in The Aging Male.

Justinas Jonusas, from the National Cancer Institute in Vilnius, Lithuania, and colleagues examined the risk for CVD mortality in a retrospective cohort study of patients aged 40 to 79 years diagnosed with prostate cancer between Jan. 1, 2012, and Dec. 31, 2016. The final cohort included 13,343 prostate cancer patients who exclusively used gonadotropin-releasing hormone agonists.

To read more Go to the Website - Click on the Link Below:

Link 1 : "Website"
or Go To
https://www.practiceupdate.com/news/38817/3/3?elsca1=emc_enews_top-10&elsca2=email&elsca3=practiceupdate_uro&elsca4=urology&elsca5=newsletter&rid=NTU2MjE4MTA4NzMS1&lid=20845145

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Us Too Warriors,
A Study - SBRT for bone metastases in oligometastatic patients

Us Too Warriors,
Consider SBRT as a way to avoid Androgen deprivation Therapy if Mets show up in a Bone scan.

I signed up for a PET bone scan at Henrico Doctors hospital on Sept 12th to see if my mets have changed from a 4+ years ago from my AXumin Scan.

Dr. Cuttino, who spoke at Our meeting a few years ago, is at Sarah Cannon Cancer Building at Henrico Doctors at Forest and Does SBRT treatment
(Jerry Deans benefited from her treatment for a while). I would have her treat me if it looks appropriate.

Best
Peter

To Read the Study Info - Click on the Link Below:

Link 1 : "SBRT"
or Go To
http://rvaprostatecancersupport.org/PDF/8 29 22 Phase 1 .pdf

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Us Too Warriors,
Cryo-Immuno Focal Clinical trial Reported in the Latest issue of Life Extension magazine website - now recruiting

Us Too Warriors,

This is a new way of attacking PCa with mets. The trial is recruiting See Belolw
Best
Peter

Cancer Therapy & Clinical-Trial Opportunity

A clinical trial uses a new combination of cryo-immune focal therapies against various types of cancer. The goal is to achieve optimal patient outcomes while avoiding serious side effects.
By William Faloon & Stephen Strum, M.D..

To go to the Website - Use the link below:

Link 1 : "'Cryo-Immuno'"
or Go To
https://www.lifeextension.com/magazine/2022/9/cancer-therapy-clinical-trial?sourcecode=CVH220E&CID=710901d4-5914-4258-8b0b-f4b4f1a219b7
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Us Too Warriors,
Paper attached that outlines how I can approach treat of my mCRPC with ARV-7 splice testosterone positive Cancer

Us Too Warriors,

The paper below is the best information I have been able to garner to give a path on treatments for my particular Flavor of mCRPC cancer. This cancer flavor occurs on Xtandi, Zytiga or Bicalutamide or " ....lutamides" when they stop working for 30%+ of men on these failed treatments.

My Bicalutamide (Casdex) worked excellently for 2 1/2 years before it failed and PSA started back up after dropping 99%. I have not been able to get the ARV-7 test because it is not FDA approved for Casodex even though ARV-7 was first found in men treated and failed with Casodex. I know I am ARV-7 because my PSA stopped doubling on Niclosamide and went down 10%. This is a crazy medical world we live and die in.

If you have mCRPC see the paper below or are being treated by ".....Lutamides or Zytiga" which are expected to fail in 3 to 6 years.
Best
Peter

Abstract:

Metastatic prostate cancer is the most common cancer in males and the fifth cause of cancer mortality worldwide. Despite the major progress in this field, leading to the approval of novel anti-androgens, the prognosis is still poor. A significant number of patients acquire an androgen receptor splice variant 7 (AR-V7), which is constitutively activated and lacks the ligand-binding domain (LBD) while maintaining the nuclear localization signal and DNA-binding domain (DBD). This conformational change, even in the absence of the ligand, allows its retention within the nucleus, where it acts as a transcription factor repressing crucial tumor suppressor genes. AR-V7 is an important oncogenic driver and plays a role as an early diagnostic and prognostic marker, as well as a therapeutic target for antagonists such as niclosamide and TAS3681. Anti-AR-V7 drugs have shown promise in recent clinical investigations on this subset of patients. This mini-review focuses on the relevance of AR-V7 in the clinical manifestations of castration-resistant prostate cancer (CRPC) and summarizes redemptive therapeutic strategies.

To Read the Paper - Use the link below:

Link 1 : "'Paper'"
or Go To
https://pubmed.ncbi.nlm.nih.gov/34073713/
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Us Too Warriors,
Video explains who should get Biopolar Androgen Therapy ( HI T) for CRPC. It works for BRAC2, ATM & P53 Mutant not ARV7

Us Too Warriors,

This video website is very informative for men with CRPC. I have been interested in BAT treatment but this video tells me that I am not a good candidate for this treatment as I believe and am trying to get a test for ARV-7 testosterone splice as my cause of cancer growth.

Jerry Deans may have benefited from this treatment as he was P53 mutated, but we did not have this information early enough before he had bone metastases.
Best
Peter

To See the Video - Use the link below:

Link 1 : "'Biopolar Androgen Therapy'"
or Go To
https://www.urotoday.com/video-lectures/asco-gu-2022/video/2563-the-state-of-bipolar-androgen-therapy-in-prostate-cancer-emmanuel-antonarakis.html
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Us Too Warriors,
losses in life from disease, aging, work and friends can lead to feelings of loneliness & depression

Us Too Warriors,

RVA Us Too Friends- Life throws us lemons and we need to make lemonade out of them. See below.
Best
Peter

To Read the Article - Use the link below:

Link 1 : "'Losses in Life'"
or Go To
https://www.medicalnewstoday.com/articles/314905
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Us Too Warriors,
My latest Armamentarium added to slow PSA now that I have CRPC as Casodex ADT Monotherapy failed Fall of 2020

Us Too Warriors,

I have added some Supplements to slow my cancer (BELOW) as my latest trial of cutting back on Niclosamide self treatment was not successful as my procedure of only drinking the white watery mix with nanoparticle powder and not the oily mix part with powder in it raised PSA to a 4 month doubling time so I am back to making it more often and drinking the oily niclosamide(2gm/day) nanoparticle part of mix the mix and the nanoparticle white 9.5 ph water too- Total mix amount of 50ml of olive oil and 16 oz of 9.5 pH water-that is microwave heated to 200C, ultra sonicated at 75C for 15 minutes, blended with 6 Oz 9.5PH twice for 50 sec, and blended 50 sec twice again with 10oz of 9.5 Ph water more added. The 16 oz are drunk half in morning and half at night with my anti (cancer, oxidant, inflammatory) pills at the same time.
Best
Peter

My latest additions to Armamentarium to fight my cancer Follow:

1. Evodia- Terra Vita; Huang DM, Guh JH, Huang YT, Chueh SC, Chiang PC and Teng CM: Induction of mitotic arrest and apoptosis in human prostate cancer pc-3 cells by evodiamine. J Urol 173(1): 256-261, 2005.
2. Citrate- Magnesium and Zinc- Swanson -reduces energy production feeding Cancer
https://www.nature.com/articles/s41598-017-04626-4#:~:text=Similar%20results%20have%20been%20observed,tumor%20growth%20and%20metastases13.
3. Citric Acid- Now real foods (see above)
4. Korean Red Ginseng - Swanson
https://www.sciencedirect.com/science/article/pii/S1226845319301642
5. Muscle and Bone Defense - Green valley Natural Solutions
https://ascopubs.org/doi/10.1200/JCO.2018.36.6_suppl.258
6. Drinking more 9.5 pH water from Kroger - Cancer cell like a low pH so give them High Ph water instead!!!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009900/
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Us Too Warriors,
Cold temperature and Beige fat burns more sugar keeping it from cancer- Until Winter- cold drinks & Ginger

Us Too Warriors,

I will be walking in colder weather with less clothes on to increase my Beige fat that burns sugar away from cancer. Until then I will be drinking cold drinks and using ginger on my food like I do most nights.
Best
Peter

To Read the Article - Use the link below:

Link 1 : "'Cold temperature'"
or Go To
https://www.sciencedaily.com/releases/2017/11/171113123731.htm
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Us Too Warriors,
Cancer Patients need to add Zinc and Magnesium CITRATE to their cancer treatment!! search online for these supplements

Us Too Warriors,

Citrate supplements can slow Prostate cancer & OTHER CANCERS. The following argument is copied from the paper Attached below. Citric acid which I have as supplement powder (very sour). Also lemon and as Limes not orange juice( too much sugar) If you do not have enough citrate in your blood the cancer will make more energy in its cells to help it grow but if you add citrate to your blood cancer will make less to grow with.

"Similar results have been observed in prostate cancer7. In vitro, several studies8,9,10,11,12 found that citrate reduced proliferation in multiple tumor cell lines. Loss of citrate synthase led to dramatically upregulated glycolysis, decreased citrate production and accelerated tumor growth and metastases13.
Best
Peter

Abstract:

In this study we have tested the efficacy of citrate therapy in various cancer models. We found that citrate administration inhibited A549 lung cancer growth and additional benefit accrued in combination with cisplatin. Interestingly, citrate regressed Ras-driven lung tumors. Further studies indicated that citrate induced tumor cell differentiation. Additionally, citrate treated tumor samples showed significantly higher infiltrating T-cells and increased blood levels of numerous cytokines. Moreover, we found that citrate inhibited IGF-1R phosphorylation. In vitro studies suggested that citrate treatment inhibited AKT phosphorylation, activated PTEN and increased expression of p-eIF2a. We also found that p-eIF2a was decreased when PTEN was depleted. These data suggest that citrate acts on the IGF-1R-AKT-PTEN-eIF2a pathway. Additionally, metabolic profiling suggested that both glycolysis and the tricarboxylic acid cycle were suppressed in a similar manner in vitro in tumor cells and in vivo but only in tumor tissue. We reproduced many of these observations in an inducible Her2/Neu-driven breast cancer model and in syngeneic pancreatic tumor (Pan02) xenografts. Our data suggests that citrate can inhibit tumor growth in diverse tumor types and via multiple mechanisms. Dietary supplementation with citrate may be beneficial as a cancer therapy.

Link 1 : "'CITRATE'"
or Go To
https://pubmed.ncbi.nlm.nih.gov/28674429/
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Us Too Warriors,
IMPORTANT Do not use LED Bulbs, Low E-Glass or Stay out of Sun. Infrared rays On our body = MELATONIN Anti-oxidants

Us Too Warriors,

I have seen some inconsistency in Vitamin D protection from Covid in which giving vitamin D to someone with low vitamin D, who is sick with covid did not have the benefit expected in stopping Covid deaths . The person needs to have a high vitamin D level before becoming sick to prevent death from covid from supplements and good amount from sun exposure. Ultraviolet sunlight exposure produces Vitamin D but the Infrared rays (the heating rays) produce Melatonin which acts as antioxidant to fight the Oxidation storm in the body which if not dampant kills a person w/covid.

Our grandparents & Great Grand parents knew this indirectly by observation and put sick people outside in the sun even in the winter. Now we are making it worse by staying indoors with air conditioning, LED Bulbs and low E-Glass Windows. I am Glad I have not replaced the old windows in my OLD house with energy efficient windows as I often thought to do. Watch the Youtube website to be informed.
Best
Peter

Sunlight: Optimize Health and Immunity (Light Therapy and Melatonin)

Link 1 : "'Sunlight'"
or Go To
https://www.youtube.com/watch?v=5YV_iKnzDRg
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Us Too Warriors,
Longer Use of Avodart( Dutasteride)and Proscar (Finasteride) reduced death by more than 1/2 from PCa in long time Users

Us Too Warriors,

I am a long time user (>8yrs) at 23 years and counting. This is best started early like right after surgery or radiation in primary treatment before PSA is<1.0 . It worked for 14 years for me. It is worth talking to your Doctor about because they block Dihydrotestosterone which grows cancer 10X faster than testosterone,
Best
Peter

Association of 5α-Reductase Inhibitors With Prostate Cancer Mortality

Abstract:

Importance There is evidence that 5α-reductase inhibitors (5-ARIs), a standard treatment of benign prostate hyperplasia, are associated with a decrease in the incidence of prostate cancer (PCa). However, studies to date have had conflicting results regarding the association with prostate cancer mortality (PCM).
Link 1 : "'Longer Use'"
or Go To
https://jamanetwork.com/journals/jamaoncology/fullarticle/2792528?guestAccessKey=a3ba6b9f-891b-4fe7-b3e4-211616194312
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Us Too Warriors,
Lactate, Lactose & Lactic Acid (in food) increases cancer growth especially as the cancer progresses

Us Too Warriors,

This increased cancer growth is evident at Biochemical cancer recurrence after primary treatment failure and when Metastasis has occurred on failure of primary treatment or on initial diagnoses (if diagnosis was not early enough to predate metastasis).

At these time points, Lactate and Lactic Acid are produced in the body from Sugar at these advanced cancer stages by what is called the "Warburg Effect". Acid pH builds up in the body's tissue around cancer mets that contribute to the deadly effects of metastases. It's best not to add to this acid effect by eating food with Lactose, lactate or lactic acid in it. Also, you need to curtail your sugar intake.

Attached below are papers discussing this problem and list of food to avoid or reduce. Drinking Milk that contains lactose (milk sugar) increases PCa diagnosis significantly see paper below.

I was a big milk drinker - gallon at a time along with ice cream and cheese - All the wrong diet for prostate cancer that had me diagnosed early at 54 years instead at the normal peak about 67 years.
See below paper with lactate/lactic acid foods to avoid especially if you have BCR & Mets as I do.
Best
Peter

Abstract
Herein, we use lessons learned in exercise physiology and metabolism to propose that augmented lactate production ('lactagenesis'), initiated by gene mutations, is the reason and purpose of the Warburg Effect and that dysregulated lactate metabolism and signaling are the key elements in carcinogenesis. Lactate-producing ('lactagenic') cancer cells are characterized by increased aerobic glycolysis and excessive lactate formation, a phenomenon described by Otto Warburg 93 years ago, which still remains unexplained. After a hiatus of several decades, interest in lactate as a player in cancer has been renewed.

Link 1 : "'lactagenesis'"
or Go To
https://pubmed.ncbi.nlm.nih.gov/27993896/

New study associates intake of dairy milk with greater risk of prostate cancer

Link 2 : "'New Study'"
or Go To
https://news.llu.edu/research/new-study-associates-intake-of-dairy-milk-with-greater-risk-of-prostate-cancer

25 Foods High in Lactic Acid

Link 3 : "'25 Foods'"
or Go To
https://futurescopes.com/health/food/59780/25-foods-high-lactic-acid

The Role of Lactate Metabolism in Prostate Cancer Progression and
Metastases Revealed by Dual-Agent Hyperpolarized 13C MRSI

Abstract:
This study applied a dual-agent, 13C-pyruvate and 13C-urea, hyperpolarized 13C magnetic resonance spectroscopic imaging (MRSI) and multi-parametric (mp) 1H magnetic resonance imaging (MRI) approach in the transgenic adenocarcinoma of mouse prostate (TRAMP) model to investigate changes in tumor perfusion and lactate metabolism during prostate cancer development, progression and metastases, and after lactate dehydrogenase-A (LDHA) knock-out. An increased Warburg effect, as measured by an elevated hyperpolarized (HP) Lactate/Pyruvate (Lac/Pyr) ratio, and associated Ldha expression and LDH activity were significantly higher in high- versus low-grade TRAMP tumors and normal prostates.

Link 4 : "'Metabolism'"
or Go To
https://www.mdpi.com/2072-6694/11/2/257
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Us Too Warriors,
For What it is Worth

Us Too Warriors,

I (Peter) should not get fatigue from Lupron. Moreover, my having GG alleles also predicts my cancer will be less aggressive than if I had CC or GC alleles which is nice to read.
The gene analyzed is the IL6-174 (rs1800795) Gene. IL6 is an Inflammatory Cytokine that makes often makes all disease worse and worse when at high levels in the blood.

Best
Peter

Genetic predictors of fatigue in prostate cancer patients treated with androgen deprivation therapy: preliminary findings

Abstract
Background: Fatigue is a common and distressing side effect of androgen deprivation therapy (ADT) for prostate cancer. The goal of the current study was to examine the relationship between changes in fatigue following initiation of ADT and single nucleotide polymorphisms (SNPs) in three pro-inflammatory cytokine genes: interleukin-1 beta (IL1B), interleukin-6 (IL6), and tumor necrosis factor alpha (TNFA).

Link 1 : " For What it is Worth"
or Go To
https://pubmed.ncbi.nlm.nih.gov/22475653/

Us Too Warriors,
Car-T studies seem to be starting to control side effects & a New type of cancer cell for CRPC has been found

Us Too Warriors,

Active Surveillance Plus Enzalutamide Monotherapy (Xtandi)vs Active Surveillance Alone in Patients With Low-risk or Intermediate-risk Localized Prostate Cancer ==>46% less progression but 56% Fatigue on Xtandi monotherapy (no Lupron added). My brother had Fatigue on Xtandi w/Lupron. I have not had fatigue on Casodex monotherapy.

Best
Peter

Link 1 : "Car-T"
or Go To
https://ascopubs.org/doi/abs/10.1200/JCO.2022.40.6_suppl.091

Home Health News - Cornell Scientists Have Identified a New Incredibly Common Subtype of Prostate Cancer
Link 2 : "Subtype"
or Go To
https://scitechdaily.com/cornell-scientists-have-identified-a-new-incredibly-common-subtype-of-prostate-cancer/

Us Too Warriors,
Free online course from John Hopkins' Dr Kenneth Pienta on Prostate Cancer treatment- next session starting Aug.1 (3WKs Long)

Us Too Warriors,

You may remember Dr Pienta who spoke well at the 2017 to 2019 Va Beach Cancer Meetings that as many as 20 of our Members attended. Jerry Deans saw him for a period of time after that meeting and other Doctors at J.H. which is known for the advanced research in PCa and is the closest to Richmond that a number of our members are treated at with advanced cancer.

I plan to take this course which will be most likely be standard of Care treatment that I have not done since my surgery in 1994.

Related Courses

Johns Hopkins University Introduction to the Biology of Cancer 4.3

Johns Hopkins University Understanding Cancer Metastasis 5.0

Johns Hopkins University Cancer Biology

Best
Peter

Link 1 : "Online Courses"
or Go To
https://www.classcentral.com/course/prostate-cancer-8070

Us Too Warriors,
Interaction Vitamin D & p53 Wild(Protective) But P53 Mut(NOTProt)

Us Too Warriors,

Jerry Deans With his p53 Mutation keeps teaching us how to protect ourselves. If you read this to the last paper you will see why I try to eat Broccoli a couple times a week and watercress as often as I can find it.
Good info follows.

Best
Peter

1st site below Vitamin D Protective when P 53 wild type still active in cancer

Link 1 : "Wild"
or Go To
https://pubmed.ncbi.nlm.nih.gov/32918225/

2nd site below Vitamin D not protective when p53 mutated most likely by metastasis if not before??? ( can be germline (inherited) or somatic developed w/Cancer progression to metastasis)

Link 2 : "Not Protective"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882298/

Website for p53 mutation testing info follows

Link 3 : "Testing"
or Go To
https://medlineplus.gov/lab-tests/tp53-genetic-test/#:~:text=A%20TP53%20genetic%20test%20looks,stop%20the%20growth%20of%20tumors

Broccoli and Watercress to Restore p53 wild type Protection and Keep Vitamin D3 fighting PCa!!!

Link 4 : "Restore"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260992/

Revisiting the Role of p53 in Prostate Cancer

Link 5 : "Role"
or Go To
https://exonpublications.com/index.php/exon/article/view/318/632#:~:text=Inactivating%20mutations%20in%20TP53%20occur,p53%20as%20a%20transcription%20factor

Us Too Warriors,
Alzheimer’s Breakthrough: Genetic Link to Gut Disorders Confirmed

Us Too Warriors,

Summary: A new study reveals a genetic link between Alzheimer’s disease and several gut-related disorders. Researchers report Alzheimer’s patients and those with intestinal disorders have specific genes in common. The findings add to the evidence the gut-brain axis may play a role in the development of neurodegenerative disorders. Source: Edith Cowan University People with gut disorders may be at greater risk of developing Alzheimer’s Disease (AD).

Please see the attached website link for details.

Best
Peter

Genes, Gut Diseases and Cholesterol are all tied to Alzheimer's that can benefit from statins like Prostate cancer can also.

Link 1 : "Alzheimer’s disease"
or Go To
https://neurosciencenews.com/alzheimers-gut-genetics-21058/

Us Too Warriors,
Curcumin, Apigenin, Berberine, Jerry Deans used to help him slow his PCa for 23 years in his Good Fight

Us Too Warriors,

Jerry Battled PCa for 23 years and found from genetic analysis he was fighting the loss of P53 anticancer gene and the harm of MDM2 to this pathway. From Us Too email messages he learned Curcumin, Apigenin, and Berberine helped his battle. Jerry lived a spiritual active life to the fullest to the end. His Church life was strong and he was also active in "Richmond Hill '' Weekend Spiritual Group. He was Active in his personal interests to the end as this last year he had his 100th dive on the reefs off the tip of Florida and camping with his family in the last few months.

One of the problems with being on clinical trials is they expect you to stop natural cancer agents which has to be a concern as they are helping in the battle. When I was sick in the middle of January 2022 and my wife died, I stopped all my treatments for a month and my PSA went from decreasing slowly to doubling every 2 weeks. I went back on the supplements/drugs and the PSA stopped growing.

Now, if Jerry were here I would tell him to add Rutin and Ginseng to Curcumin, Apigenin, and Berberine to fight his cancer P53 protection failure.

Please see the attached research paper for details.

Best
Peter

Abstract:

The p53 tumor suppressor plays a major role in controlling the initiation and development of cancer by regulating cell cycle arrest, apoptosis, senescence, and DNA repair. The MDM2 oncogene is a major negative regulator of p53 that inhibits the activity of p53 and reduces its protein stability. MDM2, p53, and the p53-MDM2 pathway represent well-documented targets for preventing and/or treating cancer. Natural products, especially those from medicinal and food plants, are a rich source for the discovery and development of novel therapeutic and preventive agents against human cancers. Many natural product-derived MDM2 inhibitors have shown potent efficacy against various human cancers. In contrast to synthetic small-molecule MDM2 inhibitors, the majority of which have been designed to inhibit MDM2-p53 binding and activate p53, many natural product inhibitors directly decrease MDM2 expression and/or MDM2 stability, exerting their anticancer activity in both p53-dependent and p53-independent manners. More recently, several natural products have been reported to target mutant p53 in cancer. Therefore, identification of natural products targeting MDM2, mutant p53, and the p53-MDM2 pathway can provide a promising strategy for the development of novel cancer chemopreventive and chemotherapeutic agents. In this review, we focus our discussion on the recent advances in the discovery and development of anticancer natural products that target the p53-MDM2 pathway, emphasizing several emerging issues, such as the efficacy, mechanism of action, and specificity of these natural products.

To Read the Info - Click on the Link Below:

Link 1 : "Research Paper"
or Go To
https://www.sciencedirect.com/science/article/pii/S2352304218300758?via%3Dihub

Us Too Warriors,
Many paper do not report the quality of life effect accurately of new drugs or over a long enough time !

Us Too Warriors,

Many cancer papers in reporting new treatments do not adequately discuss the quality of life and side effects of the treatment and Doctors are just as bad or worse in telling the whole truth as they are trying to get the patient to try the treatment and may also be mislead by the papers that only report effects for 6 to 9 months. It may take longer for the bad effects to manifest themselves. Also Doctors are concerned the patient may say no if they know the whole truth.

My experience with Xtandi is that in the first year it may seem easy to manage "Quality of Life" wise but after several years the fatigue and difficulty walking becomes unbearable for many men.

A new treatment is often Ballyhooed as being the best thing since sliced bread!! I feel I fell for that in regard to Car-T treatments I commented on recently, because I recently read that some patients on this treatment are now having severe liver reactions even to cause death in one case.

We all want something quick and easy to solve our cancer problem. But we need to be Advised "Buyer Beware"

Best
Peter

Us Too Warriors,
Up your amount of Curcumin - It stops mTOR a metastasis promotor in PCa & also destabilizes MGMT to block Alzheimer's growth

Us Too Warriors,

If you have been with Us Too for awhile you have heard me recommend Curcumin (lef.org) and know I would take as many as 12 pills per day. I have been taking 4 to 8 pills for the last year but after reading papers below I am going back to 12 pills. The reason for my increase is that in one of the papers below comparing various inhibitors of mTOR the graph shows you need a good amount of Curcumin to lower the mTOR. If you take less than enough it does no good and you are wasting your money. I want to add in passing that mTOR grows many cancers including bladder and brain cancers. My first experience with this mTOR pathway was when one of our members with Metastases to his SKull bone went to John Hopkins for a clinical trial for Rapamyacin, a drug that blocks mTOR. He was on it for at least 2 years and it cleared up his Mets. Rapamycin is hard to get because it is not considered standard of care. Curcumin is not hard to get.

mTOR also promotes Alzheimer's which is a concern in My family so blocking mTOR is something important to my family besides in cancers.

I also found that Supplement "Fisitin" I take as aromatase to block estrogen formation from my testosterone also blocks mTOR. ( that's a bonus)

Best
Peter

Past, Current, and Future Strategies to Target ERG Fusion-Positive Prostate Cancer
Abstract:
The ETS family member ERG is a transcription factor with physiological roles during development and in the vascular and hematopoietic systems. ERG oncogenic activity characterizes several malignancies, including Ewing's sarcoma, leukemia and prostate cancer (PCa). In PCa, ERG rearrangements with androgen-regulated genes-mostly TMPRSS2-characterize a large subset of patients across disease progression and result in androgen receptor (AR)-mediated overexpression of ERG in the prostate cells. Importantly, PCa cells overexpressing ERG are dependent on ERG activity for survival, further highlighting its therapeutic potential. Here, we review the current understanding of the role of ERG and its partners in PCa. We discuss the strategies developed in recent years to inhibit ERG activity, the current therapeutic utility of ERG fusion detection in PCa patients, and the possible future approaches to target ERG fusion-positive tumors.

To Read the Info - Click on the Link Below:

Link 1 : "Hitting the Golden TORget: Curcumin’s Effects on mTOR Signaling"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638063/#__ffn_sectitle

Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt/mTOR pathway: go four better to treat bladder cancer

Link 2 : "Bladder cancer"
or Go To
http://rvaprostatecancersupport.org/PDF/7 14 22 Khan2020_Article_ResveratrolCurcuminPaclitaxelA.pdf

Potential natural mTOR inhibitors screened by in silico approach and suppress hepatic stellate cells activation

Link 3 : "mTOR"
or Go To
https://www.tandfonline.com/doi/abs/10.1080/07391102.2017.1411295?journalCode=tbsd20&_ga=2.257707083.1560075554.1657828666-1040706182.1657828666#

Dietary flavonoid fisetin: A novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management

Link 4 : "Fisetin"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813433/#

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies

Link 5 : "Alzheimer"
or Go To
https://www.tandfonline.com/doi/full/10.1080/14737175.2017.1244482?scroll=top&needAccess=true

********************************************
Us Too Warriors,
NEW Prostate cancer Mutation TMPRSS2-ERG Gene Fusion paper applies to 50+% men with PCa

Us Too Warriors,

Past, Current, and Future Strategies to Target ERG Fusion-Positive Prostate Cancer

Francesca Lorenzini 1,* and Francesca Demichelis1,2,3,1Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento,38123 Trento, Italy2The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine,Weill Cornell Medical College, New York, NY 10021, USA3The Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine,New York, NY 10021, USACorrespondence: francesca.lorenzin@unitn.it (F.L.); f.demichelis@unitn.it (F.D.)

Simple Summary:
In addition to its role in development and in the vascular and hematopoietic systems, ERG plays a central role in prostate cancer. Approximately 40–50% of prostate cancer cases are characterized by ERG gene fusions, which lead to ERG overexpression. Importantly, inhibition of ERG activity in prostate cancer cells decreases their viability. Therefore, inhibiting ERG might represent an important step to improve treatment efficacy for patients with ERG-positive prostate tumors. Here, we summarize the attempts made over the past years to repress ERG activity, the current use of ERG fusion detection and the strategies that might be utilized in the future to treatERG fusion-positive tumors.Abstract:The ETS family member ERG is a transcription factor with physiological roles during development and in the vascular and hematopoietic systems. ERG oncogenic activity characterizes several malignancies, including Ewing’s sarcoma, leukemia and prostate cancer (PCa). In PCa,ERGrearrangements with androgen-regulated genes—mostlyTMPRSS2—characterize a large subset of patients across disease progression and result in androgen receptor (AR)-mediated overexpression ofERG in the prostate cells. Importantly, PCa cells overexpressing ERG are dependent on ERG activity for survival, further highlighting its therapeutic potential. Here, we review the current understanding of the role of ERG and its partners in PCa. We discuss the strategies developed in recent years to inhibit ERG activity, the current therapeutic utility of ERG fusion detection in PCa patients, and the possible future approaches to target ERG fusion-positive tumors

In another paper recently found that this mutation leads principle to Bone metastasis. This fits with my experience of a right hip bone metastasis detected in December 2017 by Axumin Scan at VCU when my cancer levels PSA =24.4 ng/ml.

Best
Peter

Past, Current, and Future Strategies to Target ERG Fusion-Positive Prostate Cancer
Abstract:
The ETS family member ERG is a transcription factor with physiological roles during development and in the vascular and hematopoietic systems. ERG oncogenic activity characterizes several malignancies, including Ewing's sarcoma, leukemia and prostate cancer (PCa). In PCa, ERG rearrangements with androgen-regulated genes-mostly TMPRSS2-characterize a large subset of patients across disease progression and result in androgen receptor (AR)-mediated overexpression of ERG in the prostate cells. Importantly, PCa cells overexpressing ERG are dependent on ERG activity for survival, further highlighting its therapeutic potential. Here, we review the current understanding of the role of ERG and its partners in PCa. We discuss the strategies developed in recent years to inhibit ERG activity, the current therapeutic utility of ERG fusion detection in PCa patients, and the possible future approaches to target ERG fusion-positive tumors.

To Read the Info - Click on the Link Below:

Link 1 : "Gene Fusion Papers"
or Go To
https://pubmed.ncbi.nlm.nih.gov/35267426/

******
Us Too Warriors,
Dr Meyers website Video on "Ways to Stop/Slow Prostate cancer Growth"

Us Too Warriors,

Jerry Joined our Us Too Group about 2006 after I had placed some flyers on our Meetings at VCU Dalton cancer clinic at which I was being treated because the doctors then treated me like a colleague and let me guide my own treatment. From about 2006 to 2014, Dr Meyers spoke at our meetings almost every year. Then Dr Meyers health started to curtail his travel. Jerry and I followed a lot of his recommendations to slow our cancer growth. Jerry, My brother, Don, and I attended a PCRI meeting together in Washington DC together in 2011. As Commereation of Jerry, I am sending a Website of Dr. Meyers 2018 Video recommendations to help slow cancer. See below for your information and health in Jerry's memory. Jerry said that attending RVa Us Too saved his life and I first attended in 1995 and it has saved my life going on 28 years. My oldest brother has been saved going on 29 years and my next oldest brother for 17 years from what I have learned being with RVA Us Too/Zero.

Use rvaprostatecancersupport.org to help your fight as well as Dr. Meyers website below to arm you for your fight in Jerry's memory.

Best
Peter

Abstract:
Purpose:
Enzalutamide, a second-generation antiandrogen, was recently approved for the treatment of castration-resistant prostate cancer (CRPC) in patients who no longer respond to docetaxel. Despite these advances that provide temporary respite, resistance to enzalutamide occurs frequently. Androgen receptor (AR) splice variants such as AR-V7 have recently been shown to drive castration-resistant growth and resistance to enzalutamide. This study was designed to identify inhibitors of AR variants and test its ability to overcome resistance to enzalutamide.

To Read the Info - Click on the Link Below:

Link 1 : "Dr Meyers"
or Go To
https://pcri.org/helpline-templates/2018/11/15/growth-arrest-approach-by-dr-myers

Us Too Warriors,
Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer

Us Too Warriors,

The abstract below also gives the basis for how and why myself made drug treatment works after casodex or Xtandi fail.

Best
Peter

Abstract:
Purpose:
Enzalutamide, a second-generation antiandrogen, was recently approved for the treatment of castration-resistant prostate cancer (CRPC) in patients who no longer respond to docetaxel. Despite these advances that provide temporary respite, resistance to enzalutamide occurs frequently. Androgen receptor (AR) splice variants such as AR-V7 have recently been shown to drive castration-resistant growth and resistance to enzalutamide. This study was designed to identify inhibitors of AR variants and test its ability to overcome resistance to enzalutamide.

To Read the Info - Click on the Link Below:

Link 1 : "Niclosamide"
or Go To
https://pubmed.ncbi.nlm.nih.gov/24740322/
*
Niclosamide jumps the hurdle of enzalutamide resistance

Jerry Deans' cancer failure initially was from Xtandi CRPC before it metastasized so much. Treatment for V7 - may have helped him at that initial stage but it was not widely known or were there any clinical trials that would allow Doctors to prescribe it or FDA approved. He fought valiantly with what was available to him through many cutting edge doctors and trials. You should now know through my efforts that you can arm yourself with some of your own effort and my help to protect you from the scourge of V7. Best Peter

What follows are Journal Editorial comments on treating V7

Link 2 : "Hurdle"
or Go To
https://www.nature.com/articles/nrurol.2014.160
*
Us Too Warriors, You should know about this test. I had not heard of it but as you can see this paper came out in 2016. I have known about ARV7+ failure of ADT for several years but I did not know or hear that doctors could test for it to see if it was occurring in your CRPC cancer until last week. This test is important to keep in mind in case you become hormone refactory=CRPC as your ADT often fails after a few years. This test can help guide your next treatment.
Website follows and then abstract:

Background - Circulating tumor cells (CTCs) expressing AR-V7 protein localized to the nucleus (nuclear-specific) identify metastatic castration-resistant prostate cancer (mCRPC) patients with improved overall survival (OS) on taxane therapy relative to the androgen receptor signaling inhibitors (ARSi) abiraterone acetate, enzalutamide, and apalutamide.

Link 3 : "AR-V7"
or Go To
https://www.europeanurology.com/article/S0302-2838(16)30857-0/fulltext

******************************************
Us Too Warriors,
Alkalazed water fights PCa - fist page of paper from Dr Snuffy Meyers
Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice

Us Too Warriors,

My Niclosamide treatment uses 9.5 pH water which may be adding to its success to stop PCa.

Best
Peter

Abstract:
The microenvironment of solid tumours is extremely acidic and this condition arises since the precancerous stage. This acidic milieu could therefore provide a useful target for both prophylactic and therapeutic approaches. In TRAMP transgenic mice, an in vivo model of prostate adenocarcinoma (AC), oral administration of alkaline water was devoid of unwanted side effects, and when started from an early age was as effective as NaHCO3 in significantly delaying tumour progression, while when started when prostate tumours were already present, a nonstatistically significant trend in the same direction was detected. These findings indicate that the use of alkalinizing drugs should be considered for chemoprevention and, in association with standard chemotherapy, for treatment of human prostate AC.

To Read the Info - Click on the Link Below:

Link 1 : "Alkalinisation"
or Go To
https://www.tandfonline.com/doi/full/10.1080/14756366.2016.1252760

Us Too Warriors,
Below is my email & Snuffy Meyers reply in regard to my email to him Yesterday and my N-1 Niclosamide Clinic trial

Us Too Warriors,

I send Dr. Meyers information about Parkinson's research several times a month over the years along with 3 other friends that came across my email from science sites.

I had not heard from him for two years until this morning. The last time was in 2020 that I heard from him - he sent me a paper on clinical trials with one person is treated with N=1. With N=1 of one - you have no control group of 1, but you can use the history of the treated person before treatment - compared to after treatment

What follows is my email to him followed by his short reply.

Snuffy,
My N-1 trial with Niclosamide, 9.5 pH water and healthy oils stop my PSA doubling time of 5 months after failure of my casodex monotherapy that had lowered my 24.4 PSA with hip bone and lymph mets in Dec 2017 to 0.0156 in June 2020 has been 100% successful over the last year.

I have been successful in stopping my PSA doubling time and lowering PSA as much as 10% twice in the last year. I have electron Microscope micrograph evidence that I can make 50 nano size particles (out of orignially 387 micron powder) in the 9.5 pH water mix with the 2g/d of niclosamide and in either heated olive oil or avocado oil, ultra sonicated and blended to make my treatment solution that I take about 8 oz twice a day. A Research paper shows that nano niclosamide can stop V7 short testosterone parts from sticking to androgen receptors after Casodex and Xtandi fail. Casodex and Xtandi can not block the V7 molecular parts from sticking to and activating the cancer receptors. Niclosamide mixture cna block the V7 part of testosterone. I am moving to an N=3 as my two brothers (Don the oldest you treated) are now joining my study. Wishing you the Best

Peter

Snuffy's email reply follows:
Very increasing

Us Too Warriors,
Two supplements to add to your PCa cancer fight = Apigenin and Berberine

Us Too Warriors,

You can get these supplements from Swanson Inc. I have been using them for years in my fight. The two websites attached below show how they can help you.

Best
Peter

Berberine Inhibits the Metastatic Ability of Prostate Cancer Cells by Suppressing Epithelial-to-Mesenchymal Transition (EMT)-Associated Genes with Predictive and Prognostic Relevance

Int. J. Med. Sci.2015, Vol. 12 http://www.medsci.org63IInntteerrnnaattiioonnaallJJoouurrnnaallooffMMeeddiiccaallSScciieenncceess2015; 12(1): 63-71. doi: 10.7150/ijms.9982Research PaperBerberine Inhibits the Metastatic Ability of Prostate Cancer Cells by Suppressing Epithelial-to-Mesenchymal Transition (EMT)-Associated Genes with Predictive and Prognostic RelevanceChia-Hung Liu1, Wan-Chun Tang2, Peik Sia2, Chi-Chen Huang3, Pei-Ming Yang2, Ming-Heng Wu4, I- Lu Lai5, Kuen-Haur Lee2 

Abstract:
Background:Over 70% of cancer metastasis from prostate cancer develops bone metastases that are not sensitive to hormonal therapy, radiation therapy, or chemotherapy. The epitheli-al-to-mesenchymal transition (EMT) genetic program is implicated as a significant contributor to prostate cancer progression. As such, targeting the EMT represents an important therapeutic strategy for preventing or treating prostate cancer metastasis. Berberine is a natural alkaloid with significant antitumor activities against many types of cancer cells. In this study, we investigated the molecular mechanism by which berberine represses the metastatic potential of prostate cancer.Methods:The effects of berberine on cell migration and invasion were determined by transwell migration assay and Matrigel invasion assay. Expressions of EMT-related genes were determined by an EMT PCR Array and a quantitative RT-PCR. The prognostic relevance of berberine's modula-tion of EMT-related genes in prostate cancer was evaluated using Kaplan-Meier survival analysis. Results:Berberine exerted inhibitory effects on the migratory and invasive abilities of highly metastatic prostate cancer cells. These inhibitory effects of berberine resulted in significant re-pression of a panel of mesenchymal genes that regulate the developmental EMT. Among EMT-related genes downregulated by berberine, high BMP7, NODAL and Snail gene expressions of metastatic prostate cancer tissues were associated with shorter survival of prostate cancer patients and provide potential therapeutic interventions.Conclusions:We concluded that berberine should be developed as a pharmacological agent for use in combination with other anticancer drug for treating metastatic prostate cancer

To Read the Info - Click on the Link Below:

Link 1 : "Berberine"
or Go To
https://click.endnote.com/viewer?doi=10.7150%2Fijms.9982&token=WzQ4NDQ5LCIxMC43MTUwL2lqbXMuOTk4MiJd.d1NDMtzVJiDmjBUb4PkRUYuB-Yk

Apigenin impedes cell cycle progression at G2 phase in prostate cancer cells

Link 2 : "Apigenin"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174405/

Us Too Warriors,
Website for paper shows Nano Niclosamide Blocks Short V7 testosterone from activating PCa cells after Casodex&Xtandi fail

Us Too Warriors,

This explains why my PCa stopped growing after I started Making and Taking Nano Niclosamide last August !
See this website

Best
Peter
Small Molecule TherapeuticsNiclosamide and Bicalutamide CombinationTreatment Overcomes Enzalutamide- andBicalutamide-Resistant Prostate Cancer
Chengfei Liu1, Cameron M. Armstrong1, Wei Lou1, Alan P. Lombard1, Vito Cucchiara1,Xinwei Gu1, Joy C. Yang1, Nagalakshmi Nadiminty1, Chong-xian Pan2,3,4,Christopher P. Evans1,3, and Allen C. Gao1,3,4
Abstract:
Activation of the androgen receptor (AR) and its splice variantsis linked to advanced prostate cancer and drives resistance toantiandrogens. The roles of AR and AR variants in the develop-ment of resistance to androgen deprivation therapy (ADT) andbicalutamide treatment, however, are still incompletely under-stood. To determine whether AR variants play a role in bicaluta-mideresistance,we developed bicalutamide-resistant LNCaPcells(LNCaP-BicR) and found that these resistant cells express signif-icantly increased levels of AR variants, particularly AR-V7, both atthe mRNA and protein levels. Exogenous expression of AR-V7 inbicalutamide-sensitive LNCaP cells confers resistance to bicalu-tamide treatment. Knockdown of AR-V7 in bicalutamide- andenzalutamide-resistant CWR22Rv1, enzalutamide-resistant C4-2B (C4-2B MDVR), and LNCaP-BicR cells reversed bicalutamideresistance. Niclosamide, a potent inhibitor of AR variants, signif-icantly enhanced bicalutamide treatment. Niclosamide and bica-lutamide combination treatment not only suppressed AR andAR variants expression and inhibited their recruitment to thePSA promoter, but also significantly induced apoptosis inbicalutamide- and enzalutamide-resistant CWR22Rv1 andC4-2B MDVR cells. In addition, combination of niclosamidewith bicalutamide inhibited the growth of enzalutamide-resis-tant tumors. In summary, our results demonstrate that ARvariants, particularly AR-V7, drive bicalutamide resistance andthat targeting AR-V7 with niclosamide can resensitize bicalu-tamide-resistant cells to bicalutamide treatment. Furthermore,combination of niclosamide with bicalutamide inhibits enza-lutamide resistant tumor growth, suggesting that the combi-nation of niclosamide and bicalutamide could be a potentialcost-effective strategy to treat advanced prostate cancer inpatients, including those who fail to respond to enzalutamidetherapy.Mol Cancer Ther; 16(8); 1521–30.Ó2017 AACR

To Read the Info - Click on the Link Below:

Link 1 : "Nano Niclosamide"
or Go To
https://click.endnote.com/viewer?doi=10.1158%2F1535-7163.mct-16-0912&token=WzQ4NDQ5LCIxMC4xMTU4LzE1MzUtNzE2My5tY3QtMTYtMDkxMiJd.FmeKKeHf6zuTalW_1CjsbS8SmNs

Us Too Warriors,
A new type Prostate cancer Cell Type discovered ==> SCL = Stem Cell Like cancer Cells

Us Too Warriors,

Check this website for information about this cell type which seems to apply to 30% of PCa. The only other two detected so far are Androgen dependent which accounts for over 50% and NeuroEndocrine (~10%?) that develops later usually during treatment often and is harder to treat.

Genetic mutations modify how these cancers act and respond to treatment .

At this time it is not clear how to detect SCL PCa or treat it as this is the early stage in the research.

Best
Peter
A previously unknown subtype of hormone-resistant prostate cancer accounts for about 30% of all cases, according to a new study from a team of scientists at Memorial Sloan Kettering Cancer Center (MSK) and Weill Cornell Medicine, published May 27, 2022, in the journal Science. The results could pave the way for targeted therapies for people with this subtype of prostate cancer.

To Read the Info - Click on the Link Below:

Link 1 : "Cell Type"
or Go To
https://www.mskcc.org/news/msk-scientists-identify-new-and-very-common-subtype-prostate

Us Too Warriors,
Statins and Metformin decrease Prostate cancer deaths! Separately and even more together

Us Too Warriors,
Statins, Metformin May Extend Survival in High-risk Prostate Cancer, Large Study Suggests
Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "Statins and Metformin"
or Go To
https://prostatecancernewstoday.com/2020/03/02/statins-may-extend-survival-high-risk-prostate-cancer-patients-retrospective-study/#:~:text=In%20this%20group%2C%20compared%20to,reduction%20in%20the%20statins%20group

Us Too Warriors,
U.S. Preventive Services Task Force (USPSTF) in 2012 and May 2022 gave PSA screening for PCa a Grade of D

Us Too Warriors,
Did Change in PSA-Based Screening Recommendation Hinder Prostate Cancer–Specific Survival?
( YES!!! Peter Moon's Comment)
Best
Peter

To Read the Info - Click on the Link Below:

Link 1 : "PSA-Based Screening"
or Go To
http://rvaprostatecancersupport.org/PDF/6 3 22 Based Screening.pdf

Us Too Warriors,
Vitamin D deficiency is associated with prostate tumor gene expression

Us Too Warriors,
In this video, Adam B. Murphy, MD, MBA, MSCI, discusses the key findings from the study, “Vitamin D has a stronger impact on prostate tumor gene expression in Black men,” which he presented at the 2022 American Urological Association annual meeting in New Orleans, Louisiana. Murphy is an assistant professor of urology and preventive medicine (cancer epidemiology and prevention) at Northwestern University Feinberg School of Medicine in Chicago, Illinois.
Best
Peter

To See the Video - Click on the Link Below:

Link 1 : "Vitamin D"
or Go To
https://www.urologytimes.com/view/researchers-identify-association-between-food-insecurity-and-urge-incontinence

Us Too Warriors,
Websites to contact to get reduced cost for Prostate cancer drugs

Us Too Warriors,
The price of PCa drugs can be out of sight without insurance and prohibitive with some insurances.
I am fortunate that my casodex treatment is off patent and considered passe so it only costs me $21 for 3 months(3 pills per day). But my oldest brother, if he did not have good insurance when treated by Dr. Meyers, would have paid $300,000 per year for Xtandi + lupron. He is now on Casodex (psa doubling every 5 months as mine did when it stopped working for me) and I am trying to get his children to Make My Nano Niclosamide treatment for him which cost about $250 for a year of the niclosamide (2grams/day), 75 cents a day for a pint 9.5 pH of water and 35 cents for thirty-five ml of Avocado oil ( for a total ~$650 per year plus a 1/2 hour per day to make).
But I have found a source of websites to contact to ask for reduction in cost for the New drugs that have replaced Casodex and others if you qualify?. See Below.
Best
Peter

To See the Blog - Click on the Link Below:

Link 1 : "Reduced Cost"
or Go To
http://rvaprostatecancersupport.org/PDF/5 30 22 Prostate cancer drugs.pdf

Us Too Warriors,
Video website by Dr. Snuffy Meyers on the use of Metformin- helpful if on ADT, metabolic sydrome & type 2 dibetes ie over weight!

Us Too Warriors,
I have been using Metformin for about 8 years to slow PSA, Check this website to hear Dr. Snuffy Meyers' Recommendations.
Best
Peter

To See the Blog - Click on the Link Below:

Link 1 : "Dr. Snuffy Meyers"
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/148048463/snuffy-myers-on-metformin

Us Too Warriors,
Mid-Atlantic Clinical trials using CAR-T for castration resistant PCa

Us Too Warriors,
if you have advanced disease this may be of interest. Clinical Trials - See below
Best
Peter

To See the Blog - Click on the Link Below:

Link 1 : "Clinical Trials"
or Go To
http://rvaprostatecancersupport.org/PDF/5 28 22 PSCA.pdf

Us Too Warriors,
Niclosamide paper attached that explain the far reaching potential for treating Multiple diseases including prostate cancer

At Thursday night's meeting, I described the process I use for making nano niclosamide solution for stopping my PCa doubling rate of every five months to actually reducing it by 10% over that period of time twice now in the last year!!!

Us Too Warriors,
Check this website for more information. See below
Best
Peter

To See the Information - Click on the Link Below:

Link 1 : " Niclosamide"
or Go To
https://www.sciencedirect.com/science/article/pii/S0898656817301018?via%3Dihub#!

Us Too Warriors,
Dr. Tanya Dorff discusses CAR T-cell research in prostate cancer

Tanya Dorff, MD, discusses findings from a phase 1 clinical trial (NCT03873805) which explored the use of chimeric antigen receptor (CAR) T-cell therapy in patients with prostate cancer. Dorff is a medical oncologist, section chief of Genitourinary Disease Program, and associate professor in the Department of Medical Oncology & Therapeutics Research at City of Hope Comprehensive Cancer Center.

Us Too Warriors,
Check this website for a 3 minute video on the early developments. See below
Best
Peter

To See the Blog - Click on the Link Below:

Link 1 : "CAR T-cell"
or Go To
https://www.urologytimes.com/view/sipuleucel-t-an-innovative-immunotherapy-option-for-metastatic-castration-resistant-prostate-cancer

Us Too Warriors,
Avodart (Dutasteride) might still be needed to block Dihydrotestosterone (DHT) while on ADT

Us Too Warriors,
Consider adding this one pill a day to slow your cancer. See below
Best
Peter

To See the Blog - Click on the Link Below:

Link 1 : "Dihydrotestosterone"
or Go To
http://rvaprostatecancersupport.org/PDF/5 18 22 Dihydrotestosterone.pdf

Us Too Warriors,
Reseach trials show that Statins and Metformin improve PCa survival - I use them Both(Statin-40mg/d & Metformin-1500mg/day)

Us Too Warriors,
My general practitioner prescribes these for me at my request as he does for all my off label drugs for my cancer( the only thing I do is have him do a physical every year & he found afib a couple of years ago during my physical). Ps. I use Pravastatin. See below
Best
Peter

To See the Blog - Click on the Link Below:

Link 1 : "Metformin"
or Go To
http://rvaprostatecancersupport.org/PDF/5 16 22 metformin.pdf

*
Us Too Warriors,
Website - with research showing the dangers of ADT (Lupron) treatment for PCa

Us Too Warriors,

Please find our support group website below which describes some of the problems for men's hearts, mind, muscles, bones, weight gain, Hot flashes, man Boobs and fatigue & frailty with muscle loss among other problems when treated with Lupron for advanced prostate cancer. Some men will not have obvious problems at first but with longer use and age they will start to show up.

Best
Peter

To see the Video/Article - Click on the Link Below:

Link 1 : "ADT (Lupron)"
or Go To
https://www.rvaprostatecancersupport.org/UsTooADT.htm

*
Us Too Warriors,
MoonShoot by US Goverment = better screening of PCa to stop Mets & men from dying, Bone scaning & Gleason scoring & profile of Advanced cancer
Patient Profile 3: High-Risk Prostate Cancer

Us Too Warriors,

The articles in "Urology Times" may help you do a better in treating your cancer found at this website that follows below.

Best
Peter

To see the Video/Article - Click on the Link Below:

Link 1 : "MoonShoot"
or Go To
https://www.urologytimes.com/view/patient-profile-3-high-risk-prostate-cancer

*
Us Too Warriors,
New Nuclear Pet Scan called "PYLARIFY" now available at Henrico Doctors Hospital (Forest)

Us Too Warriors,
Your Doctor needs to set up an appointment for you at this Hospital by calling 804-327-8702 if your PSA is going up after primary treatment. I had previously sent out to you information about this imaging at Sentara hospital in Williamsburg but this site will be closer therefore more convenient for you - it is only five minutes from my house. The copied information from Urology Times discusses the difference in the variety of Pet scan imaging treatments for your benefit.
Best
Peter

To See the Blog - Click on the Link Below:

Link 1 : "PYLARIFY"
or Go To
http://rvaprostatecancersupport.org/PDF/5 5 22 PSMA 2.pdf

*
Us Too Warriors,
Info About PSMA Scans

Us Too Warriors,
The PDF file of the Blog below describes that the scan was helpful with showing any new metastasis? Sentara's PSMA test which is thought better by some to be better than the Axumin test I had at VCU that found my metin the hip and lymph nodes. Axumin may be better if mets are near the bladder. Better results are found at higher PSA=>than .7 to 1.0 to see small cancers and to see all about 80+ % are thought to be detected while only 60 +% ( larger) are detected by older method (ie CT bone scan) and if you can not detect the cancer sites you can not possibly treat them with SBRT radiation individually or monitor how they respond to systemic treatment that is why if your PSA rises you need to get an Axumin or PSMA scan. PSMA= Prostate Specific membrane Antigen which is a molecule that is in the Membrane of the cancer for a lot of peoples cancer but not all. Therefore, you may need a test to see if your cancer has PSMA attached to the membrane and this is important for some of the advanced treatments Like the recently FDA approved LU 177 and which Jerry Dean is getting on clinical trial.
Best
Peter

To See the Blog - Click on the Link Below:

Link 1 : "Blog"
or Go To
http://rvaprostatecancersupport.org/PDF/5 3 22 BLOG.pdf

*
Us Too Warriors,
Up date on PCa treatment with emphasis on SBRT Stereotactic Body Radiation Therapy treatment

Us Too Warriors,
I think SBRT is underused to treat primary cancer and metastasis. My neighbor had his primary cancer treated by SBRT - he had a Gleason of 3+4 =7 and a PSA of 8 after 6 months of treatment his psa had fallen to 0.7 which is a very great result as a fall of 50% in that time is considered good but his fall is >90%.

I am going to try to get Dr, Cuttino to talk to us in the fall about her SBRT treatment at Henrico Doctors Hospital - She is Jerry Dean's Doctor for this treatment of which is well Pleased.
Best
Peter

*
Us Too Warriors,
Anemia in Men With Advanced Prostate Cancer: Incidence, Etiology, and Treatment

Us Too Warriors,
My older brother has had PCa for 29 years and recently his Iron level was Measured at 6% saturation in his transferrin molecules. He recently went to the emergency room because he had chest pains which can be caused by low Iron causing the heart muscles not to get enough oxygen so they are painful. ( He was not having a heart attack). Normal IRON is between 30 and 40 % saturation. I am 24 % saturated recently when I am usually between 30 to 40% saturated. Coffee and Tea drinking will sequester iron out of the body and Citrus or vitamin C pills help increase iron absorption from food like meats etc.
Best
Peter

Abstract:
Anemia associated with advanced prostate cancer is a common occurrence. This article reviews the incidence and examines the various causes of this condition, including androgen deprivation, nutritional decline, bone marrow infiltration, treatment-related toxicity, and the chronic inflammatory state. Treatment of anemia in men with advanced prostate cancer is also discussed. In patients with limited bone marrow reserve, blood transfusions may be the only effective treatment. [Rev Urol. 2004;6(1):1-4]

To read the Info - Click on the Links Below:

Link 1 : "Anemia"
or Go To
http://rvaprostatecancersupport.org/PDF/4 27 22 Anemia.pdf

*
Us Too Warriors,
Research showing Salmon may prevent PCa growth from iron in the blood

Us Too Warriors,
I am having salmon for lunch & my cat, Jesica, likes it too.
PS I will be taking my 150mg of Casodex with it.
Best
Peter

To read the Info - Click on the Links Below:

Link 1 : "Salmon"
or Go To
http://rvaprostatecancersupport.org/PDF/4 24 22 Salmon Protein Hydrolysate.pdf

*
Us Too Warriors,
Doxycycline benefit in blockoing MMPs ---- Metrix Metalloproteinases to slow Prostate cancer
and
Five Bacteria in the Urine have been associated with aggressive prostate cancer in patients

Us Too Warriors,
From the Paper - See Link below :
"In conclusion, our results indicate that doxycycline inhibits the expression of various MMPs and NF-kB signaling may have a role in the regulation of the expression of MMPs in LPS-induced PC3 human prostate cancer cells. The results of the present study may help to clarify the cellular mechanisms of the inhibitory effect of doxycycline at subantimicrobial dose in LPS-induced PC3 cells and to encourage future use of doxycycline as an additional novel therapeutic agent in prostate cancer treatment."

I worked on treating the damage of MMPs on teeth (tooth decay breakdown of Collagen) and destruction of the collagen of the periodontal ligament in Perio disease (so teeth fall out) We used Doxycycline chips, silver fluoride solutions and anti-MMP mouthwashes to stop bacterial inflammation that releases damaging MMPs during my 49 years at VCU . I will be going next week to the VCU Nano Microscope lab to examine the size of a Drug mix particles I am using to treat my cancer that has been working to stop my PSa rise.

Best
Peter

To read the Info - Click on the Links Below:

Link 1 : "Doxycycline"
or Go To
http://rvaprostatecancersupport.org/PDF/4 21 22 Doxycycline.pdf

and

Us Too Warriors, I have been taking 100mg /day of Doxycycline antibiotic to fight PCa for over 20 years- This 100mg dose is below the antibiotic dose of 200 mg /day and I have not noticed any problem over the years. I can not remember the research that started me on this path, but the papers below may support this path.
Best Peter

Link 2 : "Microbiomes of Urine"
or Go To
http://rvaprostatecancersupport.org/PDF/4 21 22 Microbiomes of Urine.pdf

Link 3 : "Five types of bacteria linked to aggressive prostate cancer"
or Go To
http://rvaprostatecancersupport.org/PDF/4 21 22 Five types of bacteria linked to aggressive prostate cancer.pdf

*
Us Too Warriors,
Comparison of CT scans (poor) with PSMA Pet and Axumin Scans (both much better than Ct scan)

Us Too Warriors,
You need a good scan to make the best decision for your treatment. The information to follow will help you understand the scans available to get a good one for you.

Below are two discussions that Show Axumin and PSMA Pet scans are much better than CT Scans for Detecting PCa Mets.
Best
Peter

To read the Blog - Click on the Link Below:

Link 1 : "Scans"
or Go To
http://rvaprostatecancersupport.org/PDF/4 16 22 PSMA PET.pdf

*
Us Too Warriors,
Use of radiosensitizers with SBRT

Us Too Warriors,
Jerry and all, I thought you might be interested in this Blog on ways that may make Radiation treatment more effective.

Best
Peter

To read the Blog - Click on the Link Below:

Link 1 : "Radiosensitizers"
or Go To
http://rvaprostatecancersupport.org/PDF/4 11 22 Radiosensitizers.pdf

*
Us Too Warriors,
Paper on how Melatonin excludes/kicks the activated androgen receptor
out of cell Nucleus to prevent the Dividing/growth of PCa cells

Us Too Warriors,
Melatonin is taken before bedtime to aid in sleep but as the paper below shows not only does it help recover of the day's stress by improving sleep it also kicks the activated androgen receptor out the nucleus so the cancer cell can not divide to grow. see below . Melatonin improves blood flow which is good for the brain, muscles and heart unless you are having surgery or internal bleeding.

Best
Peter

To read the Article - Click on the Link Below:

Link 1 : "Melatonin"
or Go To
http://rvaprostatecancersupport.org/PDF/4 1 22 Melatonin.pdf

*********************************************
Us Too Warriors,
A new wrinkle on SBRT to fight Enzalutamide & ADT with metastasis failure to fight PCa

Us Too Warriors,
This treatment used high Di Hydrotestosterone DHT) instead of testosterone on cancer cells instead of high dose testosterone as has been tested on cancer patients followed by ADT (Lupron) This "standard" SBRT" treatment has been shown to work in a number of patients (30 t0 50%?)without mets.

This "New Wrinkle'' using DHT is shown to work on cells from PCa mets men but not in a clinical trial on patients and in this cancer planted in mice.

What is interesting about this study is that DHT is expected to grow PCa cancer 10 times faster than testosterone. I have been taking dutasteride =Avodart (prescription drug) for 22 years to block an enzyme called alpha reductase which turns testosterone into DHT which slow my cancer growth from psa=0.30 to 1.0 for over 12 years and has proved by best weapon so far but to work it has to started after prostate surgery biochemical recurrence before the psa goes above 1.0 See below

Best
Peter

To see the Article - Click on the Link Below:

Link 1 : "New Wrinkle"
or Go To
http://rvaprostatecancersupport.org/PDF/3 24 22 Chen-2022-High-dose-androgen-induced-autophag.pdf

* *************************************************
Us Too Warriors,
This Week in Advanced Prostate Cancer

Us Too Warriors,
See Below for research on treatments.

Best
Peter

To see the Articles - Click on the Link Below:

Link 1 : "Week in Review "
or Go To
http://rvaprostatecancersupport.org/PDF/3 21 22 Advanced Prostate Cancer.pdf

and the new Zero Cancer Newsletter - now that Us Too prostate cancer has Joined Zero cancer.
Link 1 : "Zero Cancer Newsletter"
or Go To
http://rvaprostatecancersupport.org/PDF/3 21 22 Monday.pdf

*
Us Too Warriors,
Anemia caused by low Testosterone often produced by ADT - Iron is toxic and causes heart problems etc-See Snuffy Meyers video Below

Us Too Warriors,

See video below.

Best
Peter

To see the Video - Click on the Link Below:

Link 1 : "Anemia"
or Go To
https://askdrmyers.wordpress.com/2011/10/26/anemia-iron-and-pca/

*
Us Too Warriors,
Melatonin used as sleep aid may prevent androgen receptor from entering the cancer cell nucleus to grow the cancer

Us Too Warriors,

The use of Melatonin looks as a way of keeping androgen receptor our of the nucleus of cancer cell thereby keeping it from accelerating growth of PCa. This applies to PCa that is accelerated by testosterone like my TMPRSS2-ERG Mutant cancer gene (occurs in over 50% of men and my two brothers most likely). I have used 50mg of melatonin per night like the author of post below,

There is an important concern if you have any internal bleeding like hemorrhoids or stomach ulcers in that melatonin increases blood flow. My wife took 80mg per night of melatonin for her fibromyalgia (lack of sleep every night is the driving force for pain and fatigue she suffered) which I believe contribute to her death from internal bleeding (evident from dark tarry stool).

I have had occasional hemorrhoid bleeding so I am cutting back to 30mg/night.

In formation below copied from a PCa blog I follow.

Best
Peter To see the Posts - Click on the Link Below:

Link 1 : "Melatonin"
or Go To
http://rvaprostatecancersupport.org/PDF/3 5 22 pjoshea13.pdf

*
Us Too Warriors,
Bipolar Androgen Therapy and the Immune System
Part Three: The Potential of Combination Therapy

Us Too Warriors,

The paper below describes research at John Hopkins that shows that increasing testosterone may benefit a group of men to fight PCa. I am going to talk to my oncologist about doing it for me, but I suspect I will have to go to John Hopkins for the treatment or another University center like in Seattle or S.Carolina or New orleans with well known PCa oncologists.

Best
Peter

Some men are exceptional responders to Bipolar Androgen Therapy (BAT). Its pioneer, medical oncologist Samuel Denmeade, M.D., Co-Director of the Johns Hopkins Prostate Cancer Program, has a few patients who have remained on BAT alone for several years. But for many men, the response is temporary; just a few months. Why? Could it have something to do with mutated genes? What about the immune system?

To see the Article - Click on the Link Below:

Link 1 : "Part Three"
or Go To
https://www.pcf.org/c/bipolar-androgen-therapy-and-the-immune-system/

More Matereial - Supraphysiologic Testosterone Induces Ferroptosis and
Activates Immune Pathways through Nucleophagy in Prostate Cancer

Link 2 : "Supraphysiologic Testosterone"
or Go To
http://rvaprostatecancersupport.org/PDF/2 28 22 Kumar-2021-Supraphysiological-testosterone-ind.pdf

***
Us Too Warriors,
Melatonin can block bone met pathways for PCa

Us Too Warriors,

I have taken melatonin for many years - Usually 40 mg to 60 mg per night and if I wake in the night - I will take 20 mg to get back to sleep. I had a bone met in my right hip in Dec 2017 before going on Casodex with dutasteride. I have not had any pain in the hip or sign of a Met there???

Best
Peter

To see the Posts - Click on the Link Below:

Link 1 : "Melatonin"
or Go To
http://rvaprostatecancersupport.org/PDF/2 26 22 Melatonin.pdf

*
Us Too Warriors,
Daralutamide and Survival in Metastatic, Hormone Sensitive Prostate Cancer

Us Too Warriors,

I have been a fan of Duralutamide the latest testosterone Receptor blocker on prostate cancer cells and would like to use it as a monotherapy without ADT as I am presently doing with Casodex an early testosterone Receptor blocker on the cancer . The only way to get Daralutamide as a monotherapy, I have heard of, is to get the Duralutamide, is to get and take the Duralutamide pills and get ADT in the newest version as a pill ( Spelled something like Orv,,,,,,y) and not take these ADT pills. I have only heard of one person doing this and have not heard the results, but my Casodex monotherapy reduced my PSA by 99.9% and stopped my hip metastasis started 4 years ago. Casodex ability started to wain after 2 1/2 and now though still using it I am adding a new trick using solubilized Niclosamide that is supposed to according to research to restore Casodex's and Xtandi's punch and this new self made treatment has been working stopping the PSA doubling time of 5months and reducing the PSA by 10% over a four month period of treatment. I hope to disclose the process in a meeting in April or May as Covid I pray continues to wain.

The paper attached below shows the benefit of Duralutamide when used with ADT (which is a bad actor with such problems as weight gain, loss of mobility, muscle strength,, decreased brain function and increased heart failure among others) my oldest brother on Xtandi and ADT has experienced some of them (after being on it for about four years before dropping it). I have been able to reverse/slow his psa rise over the last three years with several off label supplements/treatments. He had Prostate surgery 29 years ago- so he is a trooper. He is on Casodex monotherapy (150mg/d) and dutasteride 0.5 mg/day now like me.
Best
Peter

Abstract
BACKGROUND
Darolutamide is a potent androgen-receptor inhibitor that has been associated with increased overall survival among patients with nonmetastatic, castration-resistant prostate cancer. Whether a combination of darolutamide, androgen-deprivation therapy, and docetaxel would increase survival among patients with metastatic, hormone-sensitive prostate cancer is unknown.

To see the Information - Click on the Link Below:

Link 1 : "Darolutamide"
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/147627062/daralutamide-and-survival-in-metastatic-hormone-sensitive-prostate-cancer

*
Us Too Warriors,
Dr. Meyers talk on vitamin D website attached

Us Too Warriors,

Those of you who have been in the group since about 2010 may remember my research on Vitamin D. I promote measurement of your blood level with a 25 Hydroxy Vitamin D test. I got the results from 60 men as to the level of their level of supplement which ranged from a low of 1000 IU/day to a high of 16,000 IU/day. I was at high end (16,000) because I am a poor absorber (only 60% absorbed in my blood) This put my blood level to near 100ng/ml of blood. This is near the limit of what you want to have and I am on a low milk and Cheese diet to reduce fat, calcium and growth hormones, all bad for the fight with PCa and heart problems. The average Vitamin D intake of the 60 men was 8,666IU (IU =Internationa Units of Vitamin D)and the Blood level average was about = 45 ng/ml which is sufficient, but Dr Meyers recommend and supplement of 5,000 to 7,000 IU/day and blood level of 80 IU to fight diseases and Cancers. Most men in the group did not reach 80ng/ml that level in their blood .

But today I got an email about Vitamin D fighting Covid in which showed in a clinical study that 25.3% of people that went to hospital with Covid with insufficient vitamin D in their blood died of Covid and only 2.5 % died if they had a good sufficient level of Vitamin D in their blood.

Best
Peter

To see the Video - Click on the Link Below:

Link 1 : "Dr. Meyers"
or Go To
https://www.bing.com/videos/search?q=dr+charles+snuffy+myers+photo&qpvt=dr+charles+snuffy+myers+photo&view=detail&mid=64ED3FFF45A6749D9C7064ED3FFF45A6749D9C70&FORM=VRDGAR

*
Us Too Warriors,
Dexamethasone is better for use with Zytiga then or after Prednisone for PCa survival

Us Too Warriors,

Objective:
To evaluate the effects of switching from prednisone (P) to dexamethasone (D) at asymptomatic prostate-specific antigen (PSA) progression in patients with metastatic castrationresistant prostate cancer (mCRPC) treated with abiraterone acetate (AA).

Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Dexamethasone"
or Go To
http://rvaprostatecancersupport.org/PDF/2 21 22 BJU International.pdf

*
Us Too Warriors,
Turkey Tail Mushrooms

Us Too Warriors,

This may be helpful-- I have been using Turkey Tail Mushrooms for many years.

Creatine powers T cells’ fight against cancer Tiare Dunlap | October 18, 2019 Creatine, the organic acid that is popularly taken as a supplement by athletes and bodybuilders, serves as a molecular battery for immune cells by storing and distributing energy to power their fight against cancer, according to new UCLA research.

Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Turkey Tail"
or Go To
http://rvaprostatecancersupport.org/PDF/2 16 22 Turkey Tail .pdf

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Us Too Warriors,
Sjöberg Prize awarded for cause of prostate cancer discovery
February 15, 2022 - Health Europa

Us Too Warriors,

This fusion defect may be the cause of your cancer( 50% chance) which makes it very responsive Di/Testosterone and it therefore responds well to T receptor blockers (like Casodex & Xtandi) and T reducers like dutasteride(avodart) and finasteride(proscar). By stating when my BCR after surgery had a PSA less than 1.0 (actually 0.3) I kept my psa increasing slowly for 13 years until it reached before it got above 1.0 which research by Dr. Gearald Androile in St louis showed it takes off like mine did for 4 years until I started Casodex in Dec 2017. I am still on it but it is slowly losing its punch after 4 years in which it dropped my psa by 99.9 %. It is back to.3 now as it was 1999 but doubling at least every 5 months or less. I am developing another horse to ride which I will explain after I work out all the details at meeting when or Email when I have tested it out. In the mean, I am testing it on my brothers so the clinical trial will have an N=3. Dr Meyers sent me a paper a few years ago talking about Clinical trials with N=1.

See website below for prize ($1 million dollars) for discovering TMPRSS2-ERG fusion gene. Cancer can produce somatic gene mutations which make your cancer get worse. Over the last 28 years so I have taken antioxidants and inflammatoires to slow this from occurring as well as diet and exercise.

Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Fusion Defect"
or Go To
https://www.healtheuropa.eu/sjoberg-prize-awarded-for-cause-of-prostate-cancer-discovery/113544/

*********************************************
Us Too Warriors,
Body fat linked to lower bone density, particularly in men
February 14, 2022 - By Mary Chris Jaklevic - FROM THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Us Too Warriors,

Read this and see what you can do with diet and exercise to reduce your waist size - I am.

Fat tends to make PCa more aggressive because the protective vitamin D is absorbed in fat cells and is not available to protect against cancer and grow bones. Also, more estrogen is produced that can go to estrogen's alpha receptor to grow the cancer.

Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Body Fat"
or Go To
https://www.mdedge.com/endocrinology/article/251748/osteoporosis/body-fat-linked-lower-bone-density-particularly-men

*************************************************
Us Too Warriors,
Bipolar Androgen Therapy - BAT to fight PCa?
January 24, 2022 | By JANET FARRAR WORTHINGTON

Us Too Warriors,

Could More Testosterone Be the Hidden Key to Fighting Prostate Cancer? Researchers Drive Prostate Cancer “BATty” - Part One: The Concept of BAT

Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "BAT to fight PCa"
or Go To
https://www.pcf.org/c/could-more-testosterone-be-the-hidden-key-to-fighting-prostate-cancer-part1/

*
Us Too Warriors,
I tried Modified Citrus Pectin many years ago as it was advertised to prevent mets and lower PSA. It was priced at about $100/month & not covered by insurance. The clinical study below I think is at a higher dose than I used - I do not expect the price has decreased. - I am looking to see what it costs now at the higher dose of 15grams /day divided into 3 doses of 5 grams on an empty stomach before meals.

The second off label treatment is CBD oil treatment of (30 +mg/dose), and I am going to increase dosing to 3 times a day which will increase the cost to $70/month and I hope to improve its effectiveness too.

See Below - Best
Peter

Introduction
With over 207,000 newly diagnosed cases in the U.S. annually, prostate cancer is the second most widespread cancer in men in the U.S. [1]. While localized treatment modalities often cure patients with localized disease, approximately 30% demonstrate biochemical relapse at ten years. The ideal management of these patients remains elusive at present. Radiation treatment given for suspected recurrent malignant disease after a period of observation after prostatectomy, also known as salvage radiation therapy (SRT), provides long-term benefits in some patients, and the use of androgen deprivation treatment (ADT) continues to be debatable [2]. While ADT effectively reduces serum PSA levels in the majority of patients, its long-term benefits on survival and quality of life remain unclear. Data emphasize the incidence of accumulative toxicities with ADT, which may offset any potential survival benefit from early intervention and impact the life quality [3].

To see the Info - Click on the Links:

Link 1 : "Citrus Pectin"
or Go To
https://www.mdpi.com/2072-6643/13/12/4295/htm

Link 2 : "CBD 2"
or Go To
http://rvaprostatecancersupport.org/PDF/1 15 22 cancers-12-03203.pdf

*
Us Too Warriors,
I have been providing my wife with CBD oil (from Hemp) for about three years which has overcome her thirty years of Pain, fatigue and poor sleep from Fibromyalgia. My wife takes a dose of 25 to 30 mg of liquid CBD oil per night before going to sleep from a dropper.

It (CBD OIL) now appears to help fight covid. My interest in CBD oil came from studies that suggest it may fight PCa. I tried a bottle 5 years ago and did not see much benefit for my cancer. I had half a bottle left and got my wife to try it - She liked it and I have been supplying her at over $1000/year since then. I am going to give it another look for PCa. I am attaching a paper on the end of this email on its benefit for PCa studies in animals. See the following:

See Below - Best For the New Year
Peter

To see the Info - Click on the Links:

Link 1 : "CBD 1"
or Go To
http://rvaprostatecancersupport.org/PDF/1 13 22.pdf

Link 2 : "CBD 2"
or Go To
http://rvaprostatecancersupport.org/PDF/1 13 22 CBD might help prime cells against COVID.pdf

*
Us Too Warriors,
Paper attached that suggest Flavanoids that help with Covid-19 - See The Flavanoids in Figure 1, I also take to fight PCa too !!!

See Below - Best For the New Year
Peter

ABSTRACT:

In terms of public health, the 21st century has been characterized by coronavirus pandemics: in 2002-03 the virus SARS-CoV caused SARS; in 2012 MERS-CoV emerged and in 2019 a new human betacoronavirus strain, called SARS-CoV-2, caused the unprecedented COVID-19 outbreak. During the course of the current epidemic, medical challenges to save lives and scientific research aimed to reveal the genetic evolution and the biochemistry of the vital cycle of the new pathogen could lead to new preventive and therapeutic strategies against SARS-CoV-2. Up to now, there is no cure for COVID-19 and waiting for an efficacious vaccine, the development of “savage” protocols, based on “old” anti-inflammatory and anti-viral drugs represents a valid and alternative therapeutic approach. As an alternative or additional therapeutic/preventive option, different in silico and in vitro studies demonstrated that small natural molecules, belonging to polyphenol family, can interfere with various stages of coronavirus entry and replication cycle. Here, we reviewed the capacity of wellknown (e.g. quercetin, baicalin, luteolin, hesperetin, gallocatechin gallate, epigallocatechin gallate) and uncommon (e.g. scutellarein, amentoflavone, papyriflavonol A) flavonoids, secondary metabolites widely present in plant tissues with antioxidant and anti-microbial functions, to inhibit key proteins involved in coronavirus infective cycle, such as PLpro, 3CLpro, NTPase/helicase. Due to their pleiotropic activities and lack of systemic toxicity, flavonoids and their derivative may represent target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections.

To see the Info - Click on the Link Below:

Link 1 : "Flavanoids"
or Go To
http://rvaprostatecancersupport.org/PDF/1 2 22 Russo-2020-Roles-of-flavonoids-against-corona.pdf

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Us Too Warriors,
What's the difference between a Urologist and a Med Oncologist??
Us Too Warriors,

I think you will find the video below informative as I did even after 28 years of fighting this battle.

The author of the video Jan Manarita is a Dedicated fighter who lost her husband to PCa and some may recognize her from her efforts to put on PCa meetings at Virginia Beach in 2017 and 2018. She has relocated to Florida but is still going strong there.

See Below - Best For the New Year
Peter

To see the Info - Click on the Link Below:

Link 1 : "Difference"
or Go To
https://www.youtube.com/watch?v=GEx65xybg4Q&t=1s

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Us Too Warriors,
Use of Prolactin blocker drug to "CURE" ADT refractory PCa
Us Too Warriors,

This is the first "cure" for cancer at this stage (ADT resistant) I have seen. If you are on ADT you may find this exciting. I have been using a low dose of Cabergoline for years as recommended by Dr. Snuffy Meyers even though I am not on ADT.

See Below - Best For the New Year
Peter

Conclusions:

This report of a novel chemotherapy for androgen-independent malignancy corroborates our understanding of the implications of prolactin in its development and treatment. There are about 165,000 cases/year with 25,000 deaths/year in the U.S.; and 1.0 million cases/year with 260,000 deaths/year worldwide. Those patients with androgen-independent prostate cancer can now employ this cabergoline treatment to prevent or terminate this deadly type of prostate cancer.

To see the Info - Click on the Link Below:

Link 1 : "CURE"
or Go To
http://rvaprostatecancersupport.org/PDF/12 27 21 nihms.pdf

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Us Too Warriors,
Niclosamide part of my new treatment that is keeping my Casodex monotherapy working after 4 years fights P53 mutation
Us Too Warriors,

Jerry Deans who is going to Chicago for LU177 Clinical trial in a few days is thought to have the P53 mutation which means his P53 anti cancer gene is negative so it no longer protects him from cancer growth. I have been on my self-directed treatment of 2 grams niclosamide in olive oil and pH 9.5 water per day which has kept my Casodex monotherapy working after it stopped about a year and 1/2 ago so PSA doubled about every 5 months after it stopped working. Fortunately, it (Casodex) worked so well my PSA was so low that I could watch it rise during the year & 1/2 from ) .015 April 2020 to 0.140 on August 2021. Now on Niclosamide in November 2021 it had my PSA=0.135 and now longer doubling and dropping slowly.

See the paper Below for information.

Best for A Merry Christmas and Keep Jerry in your Prayers.

PS. I suggest that you add Avodart to your treatment to see if you are in the 50% with TMPRSS2-ERG Mutations in their PCa,

To see the Info - Click on the Link Below:

Link 1 : "Niclosamide"
or Go To
http://rvaprostatecancersupport.org/PDF/12 20 21 Liu-2017-Niclosamide-and-bicalutamide-combin (3).pdf

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Us Too Warriors,
2021 Top Story in Prostate Cancer: An Inflection Point — The Dawn of PSMA Theranostics
Us Too Warriors,
Keep Jerry in your prayers. His cancer is extensive and showing up in his Brain, Lungs and Bones beside lymph nodes. He has had
all these areas treated with SBRT with some benefit. He is trying a new treatment called Lu 177 which has a good promise to help
in his fight. We wish him all the best in his trip to Chicago. I have added this website below to help you know about LU 177.
All the Best for the coming year. See below.
Best
Peter

To see the Website - Click on the Link Below:

Link 1 : "Inflection Point"
or Go To
https://www.practiceupdate.com/c/127381/68/3/?elsca1=emc_coll_2021TopStories2&elsca2=email&elsca3=practiceupdate_uro&elsca4=2021TopStories2&elsca5=collection&rid=NTU2MjE4MTA4NzMS1&lid=10705082

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Us Too Warriors,
This Years top story on BiPolar or Enzalutamide Treatment as which is sequenced 1st with CRPC at Abiraterone failure
Us Too Warriors,
2021 Top Story in Advanced Prostate Cancer: Bipolar Androgen Therapy vs Enzalutamide in Castration-Resistant Metastatic Prostate Cancer
Written by Brian E. Lewis MD, MPH, FACP

To see the Story - Click on the Link Below:

Link 1 : "Story"
or Go To
https://ascopubs.org/doi/10.1200/JCO.20.02759

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Us Too Warriors,
Understanding Precision Medicine for your PCa or any cancer
Us Too Warriors,
See Paper attached - Knowing the Mutation in My genes (TMPRSS2-ERG fusion) has helped me find treatments that work. The paper attached speaks to many of the known mutations and treatments that work for them in PCa. This paper did not have an answer for my mutation but my research found an answer. So once you know your mutation thru gene analysis you can go on line and find the latest research papers - You need to keep looking as new papers are coming out all the time.

To see the Info - Click on the Link Below:

Link 1 : "Precision"
or Go To
http://rvaprostatecancersupport.org/PDF/12 11 21 Precision.pdf

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Us Too Warriors,
Avodart an alpha redutase inhibitor that stops the growth of PCa with TMPRSS2-ERG Mutations(which occurs in 50% of men w/PCa)
Us Too Warriors,
See Paper attached - I started proscar in 2000 with a BCR (PSA= 0.29 6 yrs after surgery) and added Avodart in 2003 so I have used both for now for 18 years. For 13 of those years, it kept my cancer only growing slowly (PSA <1.3) because I have PCa with TMPRSS2-ERG Mutations from gene analysis by blocking the formation of Dihydrotestosterone which grows PCa 10X faster than testosterone alone.
PS. I suggest that you add Avodart to your treatment to see if you are in the 50% with TMPRSS2-ERG Mutations in their PCa,

To see the Info - Click on the Link Below:

Link 1 : " Avodart "
or Go To
http://rvaprostatecancersupport.org/PDF/12 11 21 Variability.pdf

***********************************************
Us Too Warriors,
Ivermectin (same Catergory as Niclosamide) inhibits Gastric cancer and Prostate cancer spread as anti-protease

Us Too Warriors,
See Paper attached - Generic form costs 6 cents per serving to make.
Best for the Holidays

See below.
Best
Peter

Ivermectin, a potential anticancer drug derived from an antiparasitic drug

ABSTRACT
Ivermectin is a macrolide antiparasitic drug with a 16-membered ring that is widely used for the treatment of many parasitic diseases such as river blindness, elephantiasis and scabies. Satoshi omura ¯ and William C. Campbell won the 2015 Nobel Prize in Physiology or Medicine for the discovery of the excellent efficacy of ivermectin against parasitic diseases. Recently, ivermectin has been reported to inhibit the proliferation of several tumor cells by regulating multiple signaling pathways. This suggests that ivermectin may be an anticancer drug with great potential. Here, we reviewed the related mechanisms by which ivermectin inhibited the development of different cancers and promoted programmed cell death and discussed the prospects for the clinical application of ivermectin as an anticancer drug for neoplasm therapy.

IVERMECTIN not only has strong effects on parasites but also has potential antiviral effects. IVM can inhibit the replication of flavivirus by targeting the NS3 helicase [17]; it also blocks the nuclear transport of viral proteins by acting on α/β-mediated nuclear transport and exerts antiviral activity against the HIV-1 and dengue viruses [18].

To see the Info - Click on the Link Below:

Link 1 : "Ivermectin"
or Go To
http://rvaprostatecancersupport.org/PDF/12 9 21 Ivermectin.pdf

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Us Too Warriors,
Dietary Compounds that fight cancer

Us Too Warriors,
Please read the attached paper to find what you can do (without your docs help) to fight cancer. The paper represents the many supplements and foods I have used to stop my cancer. Next year I will send out my latest treatment protocol after it has stopped my cancer for 6 months running. It has been working for four months so far - Before it was doubling every 4 months.
Best for the Holidays

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Dietary Compounds"
or Go To
http://rvaprostatecancersupport.org/PDF/11 29 21 Carlos-Reyes.pdf

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Us Too Warriors,
Statins like Pravastatin blocks "ROCK" = ROCK inhibitor which keeps cancers for spreading
(I researched this for a nephew w/Gastric cancer)

Us Too Warriors,
I have Taken Pravastatin for several years and researched it then when my GP Doctor prescribed it. I found a paper showing that it would slow PCa growth by 38%.

I also take 200 to 300 mg of CoQ10 /day along with the statin (all of them) because it can be hard on the muscles as per Research by Dr. Snuffy Meyers to the point the muscles will shrink and be painful.

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Statin"
or Go To
http://rvaprostatecancersupport.org/PDF/11 25 21 Statin.pdf

*************************************************
Us Too Warriors,
blog on " PSA rising on BAT" ==> Replies suggest how to treat it

Us Too Warriors,
This blog discusses how to do BAT treatment and by controlling DHT to keep PSA from rising by using Avodart block DHT but you have to start your Avodart at aPCA below <1.0 mine was 0.29 because I did my research as soon as the PSA came back at 5 years after surgery. If the PSA is above >1.0 when you start Avodart,

It may be slowed for a year or two before it starts growing more rapidly. I was able to use Avodart after cancer returned after surgery to control my PSA rise after surgery for 13 years. In Dec 1999, PSA = 0.29 and in Dec.2013

PSA =1.2 and Dec. 2014 PSA =2.2 . So it started to grow more rapidly and by Dec. 2017 my PSA had risen to12.2 and an Axumin scan showed mets in my right hip bone and multiple pelvic lymph >6 nodes. One of the things you need to know about Avodart is it reduces PSA put out by half so my cancer cells in December 2017 at 12.2 was actually = to a cancer mass = 24.4 PSA so it was not surprising I had metastasis. My reading of the literature is you can have mets show up with PSA in the mid teen range. see more info about Avodart use with BAT treatment.

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "BAT"
or Go To
http://rvaprostatecancersupport.org/PDF/11 12 21 PSA rising on BAT.pdf

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Us Too Warriors,
Article showing value of PSA testing - Have your Brothers, Nephews& cousins start PSA testing as they reach 40, 45and 50 years!

Us Too Warriors,
If your family has a genetic mutation for prostate cancer (like mine - 3 brothers w/PCa), it is important to start as early as 40 years old with PSA testing so you have a baseline for comparison and you can catch it early before it is dangerous.
Please Send This to the males in your family (even better to the females also) to make sure the males get to the Doctor in time!!

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "PSA Screening"
or Go To
http://rvaprostatecancersupport.org/PDF/11 4 21 PSA Screening.pdf

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Us Too Warriors,
Prostate Cancer treated with ADT Damages 21/2 more failures of the Kidneys and Antiandrogen therapy add is even worse.

Us Too Warriors,
(Link 1)This report is old (2013 ) but news to me. As we age our kidneys work less well as determined by GFR blood test - If you are in the 70 to 80yrs age range if your GFR is in the 70 to 80 ( units?) range, you are doing okay.but when you get down to 30 (units?) in your GFR you are in stage 3 kidney failure.
and
(Link 2)As many of you know I have been using Casodex for ~ 4 years to lower my PSa to undetectable for 3 of those years.

But the attached paper raises some concern about kidney function problems to the extent that the paper suggests adding testosterone to the treatment which is unusual as often casodex is used with ADT which lowers testosterone (an may not recover off of Antiandrogens like casodex etc) and does lead to kidney failure as in the last paper I sent earlier today. However, Casodex blocks testosterone from getting into cells particularly cancer cells so adding testosterone is unusual but may be necessary if you have low testosterone?

I am unusual in that I have very high testosterone ( I have never been on ADT) at 850 to 1500 units. So my kidneys have been OK with a GFR of 70 units at 81 yrs.. But if you have been on ADT or naturally have lower testosterone <450 units you may need to take some amount of testosterone to protect your kidneys as they need it to function well and if you have low kidney function testosterone may help. My Brother has low T after being on Xtandi and lupron (ADT), so he may need to talk to his Doctor about getting some testosterone patches or Injections to protect his kidneys.

This opens the questions about the effects of other Antiandrogens (besides casodex)like Xtandi, Apalutamide, Nubecqa etc on kidneys) especially when used with ADT & low testosterone Men?

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "ADT Damages"
or Go To
http://rvaprostatecancersupport.org/PDF/10 31 21 ADT Damages.pdf

Link 2 : "ADT Damages 2"
or Go To
http://rvaprostatecancersupport.org/PDF/10 31 21 ADT Damages 2.pdf

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Us Too Warriors,
Lycopene to fight Alzheimers, Parkinsons and cancers( stomach and PCa among others)

Us Too Warriors,
Lycopene that I use (40 mg/day from Puritan Pride acts as a blood thinner that lowers blood pressure and helps blood flow to the brain and kidneys for improved function. If you have low blood pressure or are on blood thinners you will need to find out the right amount for you. I have low blood pressure and some of my supplements act as blood thinners so when I had 100+ lycopene per day for a few weeks, I had some excess bleeding which stopped on 40 mg/day. Lycopene that I use (40 mg/day from Puritan Pride acts as a blood thinner that lowers blood pressure and helps blood flow to the brain and kidneys for improved function. If you have low blood pressure or are on blood thinners you will need to find out the right amount for you. I have low blood pressure and some of my supplements act as blood thinners so when I had 100+ lycopene per day for a few weeks, I had some excess bleeding which stopped on 40 mg/day.
and
When you use antioxidants to fight PCa you are also protecting yourself from Covid. In the paper that follows, I am using all but one of the supplements shown in Figure 1 that block ACE2 from getting into your cells to grow Covid. I also take at least 6 green pills a day which chelate iron so it is excreted from my body. I know that excess iron as an oxidant grows PCa and damages the brain. I have been taking green tea pills from lef.org for twenty years.(See Link 2)

ABSTRACT
Lycopene is a naturally occurring carotenoid found abundantly in red fruits and vegetables. Myriads of literature documented potential health benefits of lycopene, owing to its sublime capacity of suppressing oxidative stress, inflammation, and modulation of various cell survival pathways. Due to its lipophilic nature, lycopene can reach brain adequately by traversing the blood-brain barrier thereby extending it’s promising therapeutic benefits in neurological disorders. Lycopene efficiently assists in restoring the characteristic behavioural and pathophysiological changes associated with neurodegenerative disorders, epileptic conditions, aging, subarachnoid hemorrhage, spinal cord injury, and neuropathy. The detrimental impacts of environmental neurotoxins on brain and neuropathological consequences of consumption of high-lipid diet can also be mitigated by lycopene. Apart from its high antioxidant potency, lycopene confers neuroprotection by preventing proteinopathies, neuroinflammation, apoptosis, cerebral edema, and synaptic dysfunction. This review provides a lucid idea on the potential multi-faceted benefits of lycopene in disorders of the central nervous system and elucidates the molecular mechanisms and pathways of its action.

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Lycopene"
or Go To
http://rvaprostatecancersupport.org/PDF/10 31 21 Lycopene.pdf

Link 2 : "COVID-19"
or Go To
http://rvaprostatecancersupport.org/PDF/10 31 21 Coivid19.pdf

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Us Too Warriors,
Exercise study proves better heart and slower PSA climb for men exercising on Active surveillance for PCa

Us Too Warriors,
Effects of Exercise on Cardiorespiratory Fitness and Biochemical Progression in Men With Localized Prostate Cancer Under Active Surveillance The ERASE Randomized Clinical Trial

Dong-Woo Kang, PhD; Adrian S. Fairey, MD; Normand G. Boulé, PhD; Catherine J. Field, Ph

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Exercise"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 21 Exercise.pdf

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Us Too Warriors,
SARMs a new area of off label Drug/supplement that may or may not benefit PCa -seems best for muscle and bone loss with age or cancer

Us Too Warriors,
This is a new area, SARMs (Selective Androgen Receptor Modulators) , of investigation for me. I do not claim to know the answers. I have attached some papers that may discuss SARMs for your examination with no recommendation on my part except to inform you that the area exists. SARMs exist in a gray area in that they are not FDA approved or controlled so it is buyer beware. But they may be helpful with age or weight/muscle loss from cancer. See below. best peter

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Androgen Receptor Modulator"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 21 Androgen Receptor Modulator .pdf

Link 2 : "SARMs"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 21 SARMs.pdf

Link 3 : "Selective Androgen Receptor"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 21 Selective androgen receptor.pdf

Link 4 : "Future of Androgen"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 b21 future of androgen.pdf

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Us Too Warriors,
SARMs a new area of off label Drug/supplement that may or may not benefit PCa -seems best for muscle and bone loss with age or cancer

Us Too Warriors,
This is a new area, SARMs (Selective Androgen Receptor Modulators) , of investigation for me. I do not claim to know the answers. I have attached some papers that may discuss SARMs for your examination with no recommendation on my part except to inform you that the area exists. SARMs exist in a gray area in that they are not FDA approved or controlled so it is buyer beware. But they may be helpful with age or weight/muscle loss from cancer. See below. best peter

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Androgen Receptor Modulator"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 21 Androgen Receptor Modulator .pdf

Link 2 : "SARMs"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 21 SARMs.pdf

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Us Too Warriors,
Supraphysiological testosterone induces ferroptosis and activates immune pathways through nucleophagy in prostate cancer

Us Too Warriors,
Research at John Hopkins explains how BAT works on PCa
Best
Peter

Abstract:

The discovery that androgens play an important role in the progression of prostate cancer (PCa) led to the development of androgen deprivation therapy (ADT) as a first line of treatment. However, paradoxical growth inhibition has been observed in a subset of PCa upon administration of supraphysiological levels of testosterone (SupraT), both experimentally and clinically. Here we report that SupraT activates cytoplasmic nucleic acid sensors and induces growth inhibition of SupraT-sensitive PCa cells. This was initiated by the induction of two parallel autophagy-mediated processes, namely, ferritinophagy and nucleophagy. Consequently, autophagosomal DNA activated nucleic acid sensors that converge on NF-κB to drive immune signaling pathways. Chemokines and cytokines secreted by the tumor cells in response to SupraT resulted in increased migration of cytotoxic immune cells to tumor beds in xenograft models and patient tumors. Collectively, these findings indicate that SupraT may inhibit a subset of PCa by activating nucleic acid sensors and downstream immune signaling.

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link : "Supraphysiological"
or Go To
https://pubmed.ncbi.nlm.nih.gov/34645612/

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Us Too Warriors,
Natural Product MDM2 Inhibitors: Anticancer Activity and Mechanisms of Action help P53 anticancer gene to protect Us from cancers

Us Too Warriors,
The paper below lists natural agents that can protect us from the damage that MDM2 can inflict on the P53 anticancer gene that would cause our cancer to grow. Of the 13 agents listed, I take Curcumin, Apigenin, berberine and gambogic acid to fight PCa progression. See paper for more info.

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link : "MDM2 Inhibitors"
or Go To
http://rvaprostatecancersupport.org/PDF/10 11 21 nihms-1041464.pdf

Us Too Warriors,
Why I lift weights

Us Too Warriors,
The following blog helps explain why I lift weights (55lbs at 200 times a day) and avoid ADT.

Muscle Loss During Androgen Deprivation Therapy Is Associated With Higher Risk of Non-Cancer Mortality in High-Risk Prostate Cancer

See below.
Best
Peter

To see the Info - Click on the Link Below:

Link : "Weights"
or Go To
http://rvaprostatecancersupport.org/PDF/10 11 21 Blog.pdf

Us Too Warriors,
Why I lift weights

Us Too Warriors,
The following blog helps explain why I lift weights (55lbs at 200 times a day) and avoid ADT. See below.
Best
Peter

To see the Info - Click on the Link Below:

Link : "Weights"
or Go To
http://rvaprostatecancersupport.org/PDF/10 11 21 Blog.pdf

Us Too Warriors,
Book Chapter titled "Key Genes in Prostate Cancer Progression: Role of MDM2, PTEN, and TMPRSS2-ERG Fusions

Us Too Warriors,
The book chapter attached will apply to many men with advanced PCa. Read it carefully to see if it applied to you, I know it applies to me and my brothers with TMRPSS@-ERG fusion genes and it tells me that I and they are not likely to respond to Taxane and docetaxel and as I read elsewhere to Cisplatin treatments which I will be glad to avoid if need as they are not promising for us brothers. There is some information about the p53 gene also. See below.
Best
Peter

To see the Info - Click on the Link Below:

Link : "Key Genes"
or Go To
http://rvaprostatecancersupport.org/PDF/10 8 21 Key Genes.pdf

Us Too Warriors,
Lycopene fights PCa growth and Chemo Damage from Docetaxel & Cisplatin website below and improves kidney Function 30 to 40mg/day

Us Too Warriors,
Add cooked tomato products or Lycopene supplement from puritan pride (30 to 40 mg/day) to fight your Cancer. It also reduces peripheral neuropathy from Chemo. Lycopene is a blood thinner which helps kidneys clean your blood of toxins. to improve kidney function But if you are on a blood thinner you may want to reduce your lycopene below 40 mg /day. When I was taking about 100mg/day of lycopene, along with chrysin and fish oil are also blood thinners and I experienced a significant bleeding Until I lowered their intake. But I also improved my kidney function Glomerular filtration Rate from 52 to 72 which is good for my age.
Best
Peter

For more Info - Click on the Link Below:

Link : "Lycopene"
or Go To
https://addon.life/2021/07/05/lycopene-benefits-cancer-patients/

Us Too Warriors,
Blog on use of Bidets to help with incontinence

Us Too Warriors,
Incontinence is no fun- this may help. Peter A couple of suggestions that may make dealing with incontinence easier.
Best
Peter

For more Info - Click on the Link Below:

Link : "Bidet"
or Go To
http://rvaprostatecancersupport.org/PDF/9 24 21 Bidet.pdf

Us Too Warriors,
Cumulative use of ADT promotes Alzheimer's disease

Us Too Warriors,
My older brother was exposed to ADT for at least 4 1/2 years before he stopped because of Fatigue and trouble walking.

He is doing better on both these counts but his memory is getting more fuzzy. He has now gotten his doctor to Prescribe Casodex monotherapy which I have been using for about 4 years. Monotherapy is 3/day of 50mg casodex( bicalutamide pills) without ADT . I gave him about 3 months supply of 2 pills per day from extra's of Casodex and His PSA dropped from 20 to about 6 during that time.

This was enough to convince his Doctor to prescribe Casodex to him and to talk to him in a more personal way as before he had poor rapport.

The Doctor wanted to know how he got the casodex and he said his brother who is in the medical profession got them for him.

If you can not get your doctor to prescribe Casodex - if you want to try it; You can google "Push Pharmacy" online and "A" Doctor will send a prescription to your chosen pharmacy for a fee($). I would suggest you ask for 50mg at 3/ day for 3 months with renewal for a year.

You need to be responsive to blocking Androgen (testosterone receptor for them to help you) So if you have responded to ADT, Xtandi, Apalutamide etc

you may respond to Casodex monotherapy ( my brother was controlling his PSA to.07 on Xtandi and Adt before he stopped about 2 years ago)

If casodex stops working after about 3 to 6 years by stop taking it may cause cancer to Die in 20 to 30 % of men. One man in our group has been cancer free after stopping Casodex now for about 12 years. With my casodex failing after 3 years, PSA went from a high of 12 + in December 2017 to .015 June 2020 to now at Sept 2021 it is 0.139. With a doubling time in August 2021 of 3 months and PSA =0.14. ( Different PSA tests in Aug. and Sept.)

But In September 2021, my doubling time with "my latest Clinical trial" of N=1 was undetectable (it dropped very slightly?). I am going to run the trial for a couple more months to see that it holds up before I discuss its details.
Best
Peter

For more Info - Click on the Link Below:

Link : "Alzheimer's Disease"
or Go To
https://www.practiceupdate.com/c/124125/32/3/?elsca1=emc_conf_AUA2021Post-3&elsca2=email&elsca3=practiceupdate_uro&elsca4=202185_AUA2021Post-3&elsca5=conference

Us Too Warriors,
Prostate cancer Met cells functions as Basal or Luminal subtypes which respond differently with ADT and Chemo

Us Too Warriors,
From the papers below - it appears for survival - it is important to know which subtype of PCa you have. From my good response to Hormone/adt treatments, I surmise my cancer is Luminal. The attached paper may be helpful in guiding your treatment.
Best
Peter

To see the Info - Click on the Link Below:

Link 1 : "Link 1"
or Go To
http://rvaprostatecancersupport.org/PDF/9 24 21 jamaoncology_mabaera_2021_ic_210015_1631115307.97663.pdf
and
Link 2 : "Link 2"
or Go To
http://rvaprostatecancersupport.org/PDF/9 24 21 jamaoncology_aggarwal_2021_oi_210061_1631115289.70279.pdf

Us Too Warriors,
Characteristic of Good BAT responders included TP53 Mutations

Us Too Warriors,
This paper can help you determine if you are a good BAT ( Bipolar Androgen Therapy) responder!!!
Best
Peter

To see the Info - Click on the Link Below:

Link : "BAT"
or Go To
http://rvaprostatecancersupport.org/PDF/9 24 21 BAT.pdf

Us Too Warriors,
Chrysin for fighting Prostate and many other cancers

Us Too Warriors,
I have been using Chrysin for about 4 years as an agent to suppress my high testosterone from breaking down into Estrogen which can grow PCa if the estrogen attaches to the Alpha estrogen receptor. But the Attached paper below shows that Chrysin has a much wider way of fighting prostate cancer. See below.
Best
Peter

To see the Info - Click on the Link Below:

Link : "Chrysin"
or Go To
http://rvaprostatecancersupport.org/PDF/9 21 21 Chrysin.pdf

Us Too Warriors,
Single Lab test for detection of Multiple cancers(50+)

Us Too Warriors,
I just heard of The Galleri Lab Test For Cancers - I am just investigating it and do not know much yet but I know cancer can attack you in many organs and as we may focus on Prostate cancer. There are many other sites out there that are to protect and find out early. It is important to survive - My nephew was just diagnosed with advanced stomach cancer which is hard to deal with and I am going to my surgeon Friday to see about surgery for a melanoma (in Situ). This is my 3 or 4th melanoma so I am getting good at spotting them and other skin cancers. But most cancers are hard to detect until they are advanced so this test, if it proves as good as it sounds, is something I will want to do. Check it out for yourself and family, See Below
Best
Peter

To see the Info - Click on the Link Below:

Link : "Single Lab test"
or Go To
https://www.galleri.com/hcp/clinical-evidence

and

Link : "Multiple Cancers"
or Go To
http://rvaprostatecancersupport.org/PDF/9 16 21 Galleri-Cancers-Detected-Chart_061621.pdf

Us Too Warriors,
Monotherapy of Xtandi has positve results without the use of ADT

Us Too Warriors,
Us of ADT adds to the side effects of Anti Androgen treatment - the side effects of Xtandi and ADT were so bad ( trouble walking, fatigue and mental lapses) that my brother stopped treatment even though it was working after 4 years as prescribed by Dr Meyers. As his PSA climbed off treatment I had him use nitric oxide Snap supplement to help his muscles with walking which helped his muscles but also lowered his PSA by more than 50% for about 8 months. It (PSA) then climbed again so I gave him some of my Casdex ( 2 pills/day instead of my 3 per day) as a monotherapy and his psa is down more than 80% after 2 months. He is trying to find a Doctor in Seattle to give him Casodex as a monotherapy now we have proved it works.

But I have found a paper reporting Xtandi works as a monotherapy works see website to follow but I am concerned he will feel the fatigue and muscle loss he had before (casodex monotherapy has few side effects) so I am trying to find support for Nubequa Mono therapy ( to get a doctor to prescribe it) because it has very few side effects compared to Xtandi or Apalutamide. see website below
Best
Peter

To see the Info - Click on the Link Below:

Link : "Xtandi"
or Go To
https://ascopost.com/issues/july-25-2013/enzalutamide-monotherapy-highly-active-in-patients-with-prostate-cancer-who-have-had-no-prior-hormone-therapy/

Us Too Warriors,
Bipolar testosterone Paper Attached which agrees with Jerry Deans Improved experience

Us Too Warriors,
Objective :
To investigate whether bipolar androgen therapy (BAT), involving rapid cyclic administration of high-dose testosterone, as a novel treatment for metastatic castration-resistant prostate cancer (mCRPC) promotes improvements in body composition and associated improvements in lipid profiles and quality of life
Best
Peter

To see the Info - Click on the Link Below:

Link : "Bipolar"
or Go To
http://rvaprostatecancersupport.org/PDF/9 10 21 Marshall-2021-Reversing-the-effects-of-androgende.pdf

Us Too Warriors,
List of the Standard of Care recommend by Doctors for PCa at it verus stages for your infornamtion

Us Too Warriors,
Check out this website and compare it to what stage you think your cancer is. This is standard of care and is what most doctors will recommend unless they think outside the Box. As you know by now I think outside the box and I am testing my own concoction with niclosamide this month and hope to test its effect on PSA in the next two weeks. I am trying to see how I can obtain Nubequa antiandrogen as a monotherapy to replace my Casodex monotherapy that had been working well until lately for over 3 years.

Google this website for info
Best
Peter

To see the Info - Click on the Link Below:

Link : "Standard of Care"
or Go To
https://emedicine.medscape.com/article/2007095-overview

Us Too Warriors,
TMPRSS2

Us Too Warriors,
The attached paper is very complex but it suggests that This gene fusion may make Covid more dangerous. TMPRSS2 is one of the means by which Covid gets into our cells to damage them and being Fused to ERG does not seem to help the issue as best I read the paper. I have gotten the booster shot as has one of my brothers and I hope my other brother will too
Best
Peter

To see the Info - Click on the Link Below:

Link : "TMPRSS2"
or Go To
http://rvaprostatecancersupport.org/PDF/9 6 21 main (3).pdf

and

Chemotherapy does not look promising for me or my brothers. You can check to see if you have this gene fusion - if you need too. See attached paper.

Link : "Docetaxel Resistance"
or Go To
http://rvaprostatecancersupport.org/PDF/9 8 21 TMPRSS2.pdf

Us Too Warriors,
Covid Booster

Us Too Warriors,
I have been able to get Covid Booster shots for Myself and wife, Sue. I qualified by being prescribed a high dose prednisone ( at 60 Mg has to be 20 mg or more to qualify as an immune lowering treatment) for oral blistering drug reaction from two prescriptions in a row for tick bites. I was able to get a booster for my wife by showing the pharmacist the two papers showing that Epstein virus lowers the immune system and covid causes reactivation of EBV that is sequestered in the body and results in long Covid Haulers in 2/3 of these patients. EBV caused my wife to suffer Chronic Fatigue/fibromyalgia for 30+ years. It is a real bad actor that causes Mononucleosis in young people ie Kissing disease. It is expected that 95% of the population has been exposed to EBV and have it in their body to be reactivated by covid and may be a cause of higher death rates, So these arguments may apply to you and your family.

I went to CVS and found them hard to deal with for the shot and I found it easier getting the shot at Walmart after talking with pharmacist and pointing out that EBV corresponds to their immunosuppressive syndromes on the sheet of acceptable problems to get a shot.

See Shot info papers attached farther down
Best
Peter

To see the Info - Click on the Link Below:

Link : "Cohen"
or Go To
http://rvaprostatecancersupport.org/PDF/9 5 21 Cohen.pdf

and

Link : "Epstein-Barr"
or Go To
http://rvaprostatecancersupport.org/PDF/9 5 21 Epstein-Barr.pdf

Us Too Warriors,
Tomatoes

Us Too Warriors,
I hope you have been taking advantage of cooking tomatoes this summer because cooking them helps release them from their skin where Lycopene is found and adding some olive oil to the dish will help release it. I am into making my own cancer medicine which is lipidfilic which allows me to dissolve the active drug into olive oil which I also add 40 mg of lycopene released from their capsules by cutting them open. I will know in three weeks if it is working when I get my next PSA test to see if it has dropped or the rate of climb has stalled (presently doubling every 3 months). The paper below describes the advantage of Lycopene in Prostate , Stomach and lung cancers among others.
Best
Peter

To see the Info - Click on the Link Below:

Link : "Tomatoes"
or Go To
http://rvaprostatecancersupport.org/PDF/8 30 21 Giovannucci-1999-Tomatoes.pdf

and

Potential inhibitory effect of lycopene on prostate cancer
Studying prostate cancer is important due to its high annual incidences and mortality rates in the world. Although prostate cancer mortality rates are reduced using new therapy, complicated routes and side effects of these current drugs require a daily available treatment for prevention. Lycopene is a natural, prominent, and effective product which has a high value in diet. The anti-cancer effect, non-toxicity, safety and preventive or therapeutic roles of lycopene have been investigated in several studies. In the current review, we have collected information about the anti-cancer, anti-progressive and apoptotic effects of lycopene on prostate cancer. This article is a summary of the most important original and review articles on lycopene and its anticancer effects that are systematically categorized and presents information about the molecular structure, different sources, biological functions, and its in-vivo and in-vitro effects of lycopene on variety of cancerous and normal cells. The clinical studies provide a clear image for continuous use of this adjunctive dietary for different type of cancers, especially prostate cancer in men. In addition, this article discusses the various molecular pathways activated by lycopene that eventually prevent or suppress cancer. Lycopene has been found to effectively suppress the progression and proliferation, arrest in-cell cycle, and induce apoptosis of prostate cancer cells in both in-vivo and invitro conditions. Additionally, lycopene showed that it could modulate the signaling pathways and their protein for the treatment or prevention of prostate cancer

Link : "lycopene"
or Go To
http://rvaprostatecancersupport.org/PDF/9 1 21 Mirahmadi-2020-Potential-inhibitory-effect-of-lyco.pdf

Us Too Warriors,
Covid

Us Too Warriors,
The following website may help with Covid.

Best
Peter

Do any supplements help with the coronavirus (COVID-19)? Do supplements like vitamin D, zinc, vitamin C, or herbals work? Reviewed and edited by Tod Cooperman, M.D. Tod Cooperman, M.D.
Last Updated: 08/10/2021 | Initially Posted: 03/06/2020

To see the Info - Click on the Link Below:

Link : "Covid"
or Go To
https://www.consumerlab.com/answers/do-natural-remedies-or-supplements-prevent-coronavirus/natural-remedies-coronavirus/

Us Too Warriors,
Ivermectin inhibits HSP27 and potentiates efficacy of oncogene targeting in tumor models

Us Too Warriors,
If you get advanced prostate cancer keep the paper below in mind.

Best
Peter

HSP27 is highly expressed in, and supports oncogene addiction of, many cancers. HSP27 phosphorylation is a limiting step for activation of this protein and a target for inhibition, but its highly disordered structure challenges rational structureguided drug discovery. We performed multistep biochemical, structural, and computational experiments to define a spherical 24-monomer complex composed of 12 HSP27 dimers with a phosphorylation pocket flanked by serine residues between their N-terminal domains. Ivermectin directly binds this pocket to inhibit MAPKAP2-mediated HSP27 phosphorylation and depolymerization, thereby blocking HSP27-regulated survival signaling and client-oncoprotein interactions. Ivermectin potentiated activity of anti–androgen receptor and anti-EGFR drugs in prostate and EGFR/HER2-driven tumor models, respectively, identifying a repurposing approach for cotargeting stress-adaptive responses to overcome resistance to inhibitors of oncogenic pathway signaling.

To see the Info - Click on the Link Below:

Link : "Ivermectin"
or Go To
http://rvaprostatecancersupport.org/PDF/8 24 21 Nappi-2019-Ivermectin.pdf

Us Too Warriors,
Gargling iodine mouthwash reduces coronavirus load in patient's nose and throat, small study suggests

Us Too Warriors, Family and friends, and cancer warriors - The following may help you fight Covid in these Trying times.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Mouthwash"
or Go To
https://www.yahoo.com/lifestyle/iodine-mouthwash-reduces-coronavirus-load-160053649.html

Us Too Warriors,
Presdnisone is prescribed with Zytiga PCa treatment at 10mg/d in advanced cancer can Cause heart damage

Us Too Warriors, friends and family, I had a drug dose reaction to two rounds (10 days each hi dose 200 mg/d doxycycline) for two tick bits within 8 days of each other (to prevent Lyme disease as I had red bullseye from a bit). The high dose Doxycycline caused the roof of my mouth to break out in blisters making it hard to eat/swallow. One of my dental friends recommended a short course of prednisone and "miracle compounded mouthwash" that my dental son prescribed. It has worked well to reduce the blistering in four days.

I have learned a lot about Doxycycline and prednisone in the process that which I'm going to relay to you below.

1. I have used low dose doxycycline (100mg/day) for 14 years to prevent MMPS from the cancer cells from promoting Metastasis so I already had doxycycline primed in my system before I started on the higher doses.
2. Doxycycline reduces Tau and amyloid plaques in the brain to keep the brain better functioning against Alzheimer's.
3. Prednisone raises the heart rate in my case low thirties for me (BPM) to 55 to 65 BPM. which is the normal range.
4. Prednisone makes afib conversion better by stopping inflammation of the heart muscle.
5. If you are on high doses of prednisone for any period of time you will have withdrawal symptoms if you do not taper off slowly.
6. My prescription for the blisters had built in taper off = 4 days at 60mg; 4days at 40 mg and 4days at 20 mg.
7. Prednisone causes heart disease even at 5 mg/day (74% increase) if used for any period of time. Higher the dose the worse the heart is made.
8. See the attached paper for more info below

Read below for more information.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Prednisone"
or Go To
https://www.sciencedaily.com/releases/2020/12/201203144217.htm

*********************************************
Us Too Warriors,
My list of Covid-19 Supplements & Drugs from Research & Googling online to meet Delta, Columbian strains & waning of the Vaccine

Friends and family-This is my list if you want the details you can google search for information If it has a "" it will help fight PCa. Most of these can be bought from Swanson, Inc.

1. Vitamin D3- 8000 IU per day ( prevents death ~50%)
2, nitric Oxide booster by Snap Inc - prevents lung Clots*
3, Lactoferrin- How ? * check it out I forgot
4. Black seed Cumin Source of Thymoquinone ==>fights Cytokine Storm/inflammation *
5. Curcumin -anticlotting blood thinning anti-inflammatory fights Covid and PCa*
6. Tetanus Shot boosts the immune system and I think the FLu shot will too?
I do all the above as you might expect as I believe in Belts and Suspenders.

You will Notice that that all these Supplements that fight Covid fight prostate cancer so it is nice to get two benefits for the price of One.

Also I am reading that Moderna vaccine keeps its potency longer against covid than Pfizer.

******
Us Too Warriors,
Cognitive Decline Associated With Anesthesia and Surgery in Older Patients

At 54 years old my PCa surgery caused me to lose my spatial map in my head for driving in Richmond for at least 5 years. I do not know if I relearned it by driving or if it came back on its own? But now I can recall in my mind the street connections to get me to a place I know in my mind.

So I believe Surgery & anesthetics can hurt your mind so it is a side effect you need to be aware of if your doctors recommend Surgery.

For my last Melanoma surgery that required surgery under my arm to remove a lymph node to prove I was cancer free; I got my doctor with local lidocaine which she agreed to as she had done a surgery like that for a pregnant woman.
Read below for more information.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Cognitive Decline"
or Go To
http://rvaprostatecancersupport.org/PDF/8 9 21 jama.pdf

Us Too Warriors,
Adjuvant Treatment to many types of cancer, LEF protocol attachment for your Info

Over the years it has been obvious for selves and families we need to be able to defend against many health issues and cancers besides Prostate cancer. I have had 5 skin cancers (2 were melanomas) removed in the last five years and one on my wife. I have already helped my family in their treatment of two Prostate cancers (both brothers) kidney cancer and lung cancer. Recently, a family member who ate too many hot peppers has been diagnosed with stomach cancer, a common problem in Mexico. With that in mind I have attached a Life Extension protocol below that discusses many adjuvant treatments to make understanding and treating many of the cancers we are subject to as well as prostate cancer possible. I hope this will make you better able or your family better able to defend against them.

Read below for more information.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Adjuvant Treatment"
or Go To
https://www.lifeextension.com/protocols/cancer/cancer-adjuvant-therapy

Us Too Warriors,
Covid long haulers are tied to reactivation of Latent Epstein-Barr Virus (95 % of adults have latent EBV in their blood)

Black seed Cumin {Nigella (N. sativa)} by Swanson Inc , I discussed as a source of Thymoquinone to promote the immune system and fight Prostate cancer at one of our Us Too meetings about 5 years ago. Well, now it is being tested by NIH to fight long term Covid in a Phase 1 trial. This is a particular concern for me as my wife as I believe she got Fibromyalgia from a bout with EBV! EBV is also the cause of mononucleosis = the Kissing disease. Remember 95 % of people have this latent virus in their body so if you have weak immune system it is likely to reactivate if you get covid - I recommend that you start taking Black cumin seeds as a preventative.
Read below for more information.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Black Seed"
or Go To
http://rvaprostatecancersupport.org/PDF/8 4 21 Taborsky-2012.pdf

*

Link : "Epstein-Barr-virus"
or Go To
http://rvaprostatecancersupport.org/PDF/8 4 21 Epstein-Barr-virus.pdf

****************************************
Us Too Warriors,
Discussion of Focal therapy for PCa for local PCa

If you have MRI or other imaging biopsy that shows your cancer is localized/small, not high gleason and not near an area hard to treat you may be a candidate for focal therapy.
Read below for more information.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Focal Therapy"
or Go To
http://rvaprostatecancersupport.org/PDF/8 2 21.pdf

Us Too Warriors,
Paper describing benefits of Vitamins K1 and K2 for many health issues including PCa

Read below and consider if you should not add vitamin K2 supplements to your armamentarium. I learned of the value of Vitamin K in my research career for jaw bone health and its use to prevent osteoporosis. Presently I am recommending its supplementation in children to VCU Pedontics department to prevent tooth decay in children. We have already shown the benefit of vitamin D3 to prevent tooth decay in children in a clinical study at VCU. Vitamin D3 supplementation increases gut calcium absorption and Vitamin K2 sends the Calcium to the bones thus keeping it out of blood vessels (preventing hardening of the arteries).
Read below for more information.

Best
Peter

To see the Info - Click on the Link Below:

Link : "K2"
or Go To
http://rvaprostatecancersupport.org/PDF/7 27 21 Vit K.pdf

Us Too Warriors,
Tetenas and diptheria and petussas vaccine can boost imuune system
improves Immune system and reduces Covid side effects by 50%

I recently got Tetanus and diphtheria and pertussis Vaccine at Patient 1st as a way to boost my Covid Vaccine as it is about 6months from my 2nd Pfizer shot for Covid-19. I went there to get doxycycline for possible tick bite as I had red bulls eye on my leg characteristic of the bite. I normally take 100mg pill per day to slow PCa metastasis, but Two 100 mg pills a day are the treatment for Tick bites. I have found 6 ticks crawling on my body in the last few weeks but none had bite thru the skin that I knew of.
Read below for more information.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Old Vaccine"
or Go To
http://rvaprostatecancersupport.org/PDF/7 24 21 Prior-vaccination.pdf

Link : "Old Vaccine Article"
or Go To
https://www.medicalnewstoday.com/articles/old-vaccines-for-covid-19-tetanus-diphtheria-show-promise

Us Too Warriors,
New drug for PCa & Breast cancer to breakdown AR-V7 short androgen = receptor activators ( PCa on all the time= Anti adrogens don'twork)

You have seen emails from me about developing worm Pill=Nicolaosamide to break down AR-V7. I have found out this niclosamide is not very soluble so it has to be micronized to size of about 1 micron to make it work in the body in a "Jet Mill" I am waiting for delivery of Niclosamide from Germany but I think it is being held up by the flooding there. Also I may have to get a Jet Mill to make it work??

In the meantime, I found the paper attached (by one of the researchers who tested Niclosamide) on a new drug (ARVib) being developed to block AR-V7.

Pfizer is investing 1 billion dollars to bring it to market in partnership with a small drug company ARVINAS that developed it. They are aiming to tackle breast cancer first so I expect it will be 5 years at least before it is available for PCa. So for now I will be pursuing niclosamide.

Best
Peter

To see the Info - Click on the Link Below:

Link : "New Drug"
or Go To
http://rvaprostatecancersupport.org/PDF/7 23 21 Liu-2021.pdf

Us Too Warriors,
Niclosamine and Indomethacin May make Anti-androgens like Casodex, Enzalutamide work after they start to fail do to AV-7

This is a treatment I am investigating as my casodex is starting to fail after 3 years. I will start it within a month and may know how it is working by the fall. See abstract and patent that follow. Wish me well and I hope it can help others in our group.
Abstract:

Enzalutamide and Indomethacin in Treating Patients with Recurrent or Metastatic Castration-Resistant Prostate Cancer

This phase I / II trial studies the side effects of enzalutamide and indomethacin and to see how well they work in treating patients with prostate cancer that does not respond to treatment with hormones despite surgical removal of testes (castration-resistant), has come back (recurrent), or has spread from where it started to other places in the body (metastatic). Androgens can cause the growth of prostate cancer cells. Indomethacin is a non-steroidal anti- inflammatory drug that has been found to block one of the signals that enhance prostate cancer cell growth. Hormone therapy using enzalutamide and indomethacin may fight prostate cancer by lowering the amount of androgen the body makes and / or blocking the use of androgen by the tumor cells.

Location: University of California Davis Comprehensive Cancer Center, Sacramento.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Patent"
or Go To
http://rvaprostatecancersupport.org/PDF/7 12 21 Patent Application.pdf

*
Us Too Warriors,
Niclosamide and Bicalutamide Combination Treatment Overcomes Enzalutamide
and Bicalutamide-Resistant Prostate Cancer

Abstract:

Activation of the androgen receptor (AR) and its splice variants is linked to advanced prostate cancer and drives resistance to antiandrogens. The roles of AR and AR variants in the development of resistance to androgen deprivation therapy (ADT) and bicalutamide treatment, however, are still incompletely understood. To determine whether AR variants play a role in bicalutamide resistance, we developed bicalutamide-resistant LNCaP cells (LNCaP-BicR) and found that these resistant cells express significantly increased levels of AR variants, particularly AR-V7, both at the mRNA and protein levels. Exogenous expression of AR-V7 in bicalutamide-sensitive LNCaP cells confers resistance to bicalutamide treatment. Knockdown of AR-V7 in bicalutamide- and enzalutamide-resistant CWR22Rv1, enzalutamide-resistant C4- 2B (C4-2B MDVR), and LNCaP-BicR cells reversed bicalutamide resistance. Niclosamide, a potent inhibitor of AR variants, significantly enhanced bicalutamide treatment. Niclosamide and bicalutamide combination treatment not only suppressed AR and AR variants expression and inhibited their recruitment to the PSA promoter, but also significantly induced apoptosis in bicalutamide- and enzalutamide-resistant CWR22Rv1 and C4-2B MDVR cells. In addition, combination of niclosamide with bicalutamide inhibited the growth of enzalutamide-resistant tumors. In summary, our results demonstrate that AR variants, particularly AR-V7, drive bicalutamide resistance and that targeting AR-V7 with niclosamide can resensitize bicalutamide-resistant cells to bicalutamide treatment. Furthermore, combination of niclosamide with bicalutamide inhibits enzalutamide resistant tumor growth, suggesting that the combination of niclosamide and bicalutamide could be a potential cost-effective strategy to treat advanced prostate cancer i

Best
Peter

To see the Info - Click on the Link Below:

Link : "Niclosamide and Bicalutamide"
or Go To
http://rvaprostatecancersupport.org/PDF/7 9 21 Niclosamide-and-bicalutamide-combin.pdf

*
Us Too Warriors,

Virtual Prostate Cancer Patient Festival-The National Prostate Cancer Conference Online
with presentations.

Various Dates and Times

Prostate Cancer Patient Conferences - A Festival Of Zoom Prostate Cancer Care

Best Peter

Click on the Link below to For More Information.

Link: Festival

https://www.eventbrite.com/e/prostate-cancer-patient-conference-a-festival-of-prostate-cancer-care-tickets-118358165459

*
Us Too Warriors,
SBRT supports rariation in 3 to 4 metastasis in many cancers

Abstract below for your information. it used a range of radiation levels from 30 gray total in 3 application to 50 grey total in 5 applications

Best
Peter

Abstract:

Importance: Stereotactic body radiotherapy (SBRT) for oligometastases is hypothesized to improve survival and is increasingly used. Little evidence supports its safe use to treat patients with multiple metastases.

Objective: To establish safety of SBRT dose schedules in patients with 3 to 4 metastases or 2 metastases in close proximity to each other.

To see the Info - Click on the Link Below:

Link : "SBRT"
or Go To
https://pubmed.ncbi.nlm.nih.gov/33885704/

*
Us Too Warriors,
blog and paper Sugesting Active Vitamin D drug, Calcitriol, and Panax Ginseng together fight PCa

You will see in the Blog, comment by Pedro Luna which is my pseudonym. I have used Calcitriol & Panax Ginseng together for many years.

I am now supplying my excess Calcitriol to my brothers.

Best
Peter

To see the Blog - Click on the Link Below:

Link : "Blog"
or Go To
https://healthunlocked.com/user/Graham49

*
Us Too Warriors,
CBD effects apoptosis in all 4 PCa cell lines -- significantly enhanced the anti‐cancer effects of bicalutamide

The results obtained can be summarized as follows. Firstly, cannabinoids and BDS reduced PCC viability with higher potency and efficacy in the absence of serum proteins, and regardless of the presence of hormones in the medium and of the androgen dependency of the PCC line under study. With serum deprivation, CBD was the most efficacious compound in three out of the four cell lines investigated. These results are in full agreement with previous observations in glioma cells (Jacobsson et al., 2000). Secondly,amongst all the possible known cannabinoid targets investigated, only TRPM8 channels, when present (as in LNCaP cells), seemed to mediate, and only in part, the effect of CBD. Finally, under certain dosing conditions, CBD produced synergistic effects with docetaxel and/or bicalutamide in DU‐145 and/or LNCaP cells.

Best
Peter

To see the Info - Click on the Link Below:

Link : "CBD"
or Go To
http://rvaprostatecancersupport.org/PDF/6 23 21 De-petrocellis.pdf

*******************************************
Us Too Warriors,
Vitamin K2 supplementation to fight PCa, Heart disease and chronic kidney disease

I am just reordering My " Mega Vitamin K2 supplement" from Lef.org . I am recommending it to my brothers both for PCa and one with chronic Kidney disease and the other with heart related carotid artery calcification surgery for 80% blockage. Read the attachments below as it is hard to get enough Vitamin k2 from leafy green vegetables for what we need as we Age.

I am working with the VCU pedodontics department to see if I can interest them in a clinical trial of Vitamin K2 in young children as I have in the past done with vitamin D3 as a way to prevent cavities in young children. Think about your GrandChildren for Vitamins D3 & K2.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Vitamin K2"
or Go To
http://rvaprostatecancersupport.org/PDF/6 20 21 Juanola-falgarona-2014-Dietary-intake-of-vitamin-k-is-inve-1.pdf
*
Vitamin K role in mineral and bone disorder of chronic kidney disease

Link : "Vitamin K2 - Kidney Disease"
or Go To
https://pubmed.ncbi.nlm.nih.gov/31836502/

*********************************************
Us Too Warriors,
Selective androgen receptor modulators- SARMs look very promising as new PCa treatment -available without a prescription

This SARMs use for PCa is new to me as of today and it has been Clinically tested at U. of Washington. I am ordering some online to try today.

It is used by weight lifters and is good to build muscle, fat loss and bone health as well as prevent muscle wasting (cachexia) from cancer.

It has positive benefits for these conditions as opposed to these negative conditions produced by Lupron ADT.

Best
Peter

To see the Info - Click on the Link Below:

Link : "SARMs"
or Go To
http://rvaprostatecancersupport.org/PDF/6 18 21 SARM.pdf

*
Us Too Warriors,
PSMA imaging test now availble in Fort Lauderdale

This test recently approved for imaging advanced cancer. See below.

Best
Peter

To see the Info - Click on the Link Below:

Link : "Pylarify"
or Go To
http://rvaprostatecancersupport.org/PDF/6 18 21 Pylarify.pdf

**
Us Too Warriors,
My added Complementary treatment to PCa battle ==> is Edame soybeans for cooked dinner(frozen Krogers) + Fucoxanthin 2g/d (Swanson)

Abstract

Background:Prostate cancer is the most common cancer in men in the United States. Fucoidan is a bioactivepolysaccharide extracted mainly from algae. The aim of this study was to investigate anti-tumor and anti-angiogeniceffects of fucoidan in both cell-based assays and mouse xenograftmodel,aswellastoclarifypossibleroleofJAK-STAT3pathway in the protection.

Methods: DU-145 human prostate cancer cells were treated with 100–1000μg/mL of fucoidan. Cell viability, proliferation,migration and tube formation were studied using MTT, EdU, Transwell and Matrigel assays, respectively.Athymic nude mice were subcutaneously injected with DU-145 cellsto induce xenograft model, and treated by oral gavagewith 20 mg/kg of fucoidan for 28 days. Tumor volume and weight were recorded. Vascular density in tumor tissue wasdetermined by hemoglobin assay and endothelium biomarker analysis. Protein expression and phosphorylation of JAK andSTAT3 were determined by Western blot. Activation of gene promoters was investigated by chromatin Immunoprecipitation.

Results: Fucoidan could dose-dependently inhibit cell viability and proliferation of DU-145 cells. Besides, fucoidan alsoinhibited cell migration in Transwell and tube formation in Matrigel. In animal study, 28-day treatment of fucoidansignificantly hindered the tumor growth and inhibited angiogenesis, with decreased hemoglobin content and reducedmRNA expression of CD31 and CD105 in tumor tissue. Furthermore, phosphorylated JAK and STAT3 in tumor tissuewere both reduced after fucoidan treatment, and promoter activation of STAT3-regulated genes, such asVEGF,Bcl-xLandCyclin D1, was also significantly reduced after treatment.

Conclusions: All these findings provided novel complem

See below Website !!

Best
Peter

To see the Website - Click on the Link Below:

Link : "Fucoxanthin"
or Go To
https://bmccomplementmedtherapies.biomedcentral.com/track/pdf/10.1186/s12906-017-1885-y.pdf

Us Too Warriors,
Blog discussing the delaying ADT along with intermittent ADT and adding testosterone Use???

The blog is complex and it is difficult to instigate this treatment of delaying ADT along with intermittent ADT along with testosterone use (hard to find doctors to help).

Many of the men have initiated it on their own one using estrogen instead of Lupron to lower testosterone.

The treatment is designed to prevent the cancer from becoming Castration resistant as often happens on ADT lupron after a few years.

See below if you are on ADT, have been on it or might have a doctor who may wants you to go on this Standard of Care?

Best
Peter

To see the Blog - Click on the Link Below:

Link : "Blog"
or Go To
https://healthunlocked.com/user/pjoshea13

Us Too Warriors,
New Australian Drug for very Advanced PCa w/ SBRT radiation or
Lu177 increases Median Survival from 5 to 20 months!!

Check Out this website for Information and it may be in clinical trials in the USA?

Best
Peter

To see the Website - Click on the Link Below:

Link : "Survival"
or Go To
https://www.outsourcing-pharma.com/Article/2021/03/02/Prostate-cancer-treatment-shows-major-survival-benefit

Us Too Warriors,
Melatonin and Doxycycline Blog attached to prevent/slow PCa cell migration and Mets

Read the blog below to see how to slow/prevent PCa cell migration to new organs called the EMT progression/transition. In the E=Epithilial stage the cells bind together but M=Mesenchymal where the cells do not bind together and they can float/migrate off to do damage in other organs.

I use 50 mg of melatonin at night at bedtime and if I wake I take 20 more. I take 100mg of doxycycline which I know from research in dental diseases ( tooth decay and periodontal infections) are prevented or reduced by doxycycline by preventing Matrix Metalloproteinases (MMPs) from breaking down collagen in the periodontal ligament fixing our tooth roots in to our jaw bone. When the MMPs break down the ligaments the roots come loose from the jaw and fall out. Also, the collagen in the dentin under the enamel of our teeth, is attacked by decay's MMPs turning it into a mushy of gelatin at the decay site. MMPs are shot out of invadopodia spikes on our cancer cells to drill through the extracellular matrix holding the cells in place so they can migrate to form mets in other organs and bones to do damage. You can see my dental research primed me to understand cancers ways of action,

Please read the following to inform yourself:

Best
Peter

To see the Blog - Click on the Link Below:

Link : "Blog"
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/146255838/melatonin-suppressed-pca-cells-migration-and-invasion-by-blocking-emt-epithelial-mesenchymal-transition

Us Too Warriors,
Aplutamide with ADT for men with more aggresive PCa responded better than men with less agressive PCa

It is hard to know the outcome of a treatment until it is tested or you try it. So there is hope it can work for you. See the paper attached below

Best
Peter

To see the Info - Click on the Link Below:

Link : "Aplutamide"
or Go To
http://rvaprostatecancersupport.org/PDF/6 4 21 jamaoncology_feng_2021_oi_210018_1621868087.01914-1.pdf

Us Too Warriors,
Paper comparing 2nd & 3rd level Antiandrogens Apalutamide, Enzalutamide, and Darolutamide Clinicla trials nmCastration resistant PCa

The paper attached below describes the side effects found in the Clinical trials and the effectiveness in treating nmCastration resistant PCa.

My brother had to stop Enzalutamide as the fatigue was so great it interfered with his mobility/walking. This fatigue problem was also pointed out by the clinical trial. He is trying a short course of Casodex as monotherapy, a level 1 antiandrogen, that has worked for me going on 3 1/2 years. If and when Casodex fails for me I would consider Darolutamide as it has the best side effect profile except Afib. See the attached paper to inform yourself.

Best
Peter

To Go to the Website - Click on the Link Below:

Link : "Antiandrogens"
or Go To
http://rvaprostatecancersupport.org/PDF/6 3 21 s41391-020-00310-3.pdf"

Us Too Warriors,
Covid -19 relationship to men, DHT and testosterone Hormones

Researchers are starting to Understand more of the factors that influence Covid-19 danger to men. See the website attached for more information.

Also I read that nitric oxide in our bodies stimulate Filiae to move more in our nose and nasal passages to sweep bacteria and Virus out to protect us.

Best Memorial Day for your Loved Ones and for the Many Brave Sacrifices.

Best
Peter

To Go to the Website - Click on the Link Below:

Link : "Covid-19"
or Go To
https://www.medicalnewstoday.com/articles/coronavirus-treatment?utm_source=Sailthru%20Email&utm_medium=Email&utm_campaign=dedicated&utm_content=2021-05-30&apid=27042543&rvid=db97d9a92fcbfbf765e6cd661b725b285374ddc232f43e4263e157b240b215c9

Us Too Warriors,
Too back up your Glucose restriction by lowering Glutamine and Glutamate with supplements and to slow PCa growth

Check out the website below for more information:

Here are 10 foods that can block glutaminase in research. I take 3 pills per day of the items marked with @

EGCG (Green tea)@
Curcumin (Turmeric root)@
Lycopene (Tomatoes)@
Ursolic Acid (Holy basil, pistachio nuts, Rosemary)@
Resveratrol (Red grape skins)@
Honokiol, magnol (Magnolia Bark Extract)@
Graviola (Soursop)
Sulforaphane (Sprouting seeds)@
Valerian
Withanolide (Ashwagandha)@

Best
Peter

To Go to the Website - Click on the Link Below:

Link : "Foods"
or Go To
https://www.canceractive.com/article/glutamine-glutamate-diet-and-cancer

Us Too Warriors,
STOP FIGHTING CANCER and Start Treating the Cause

The book copied below has many suggestions for treating prostate cancer inflammation and antioxidants that I have used for years. Give it a look and see if it can help in your treatment. It was sent to me by the Doctor Wife of one of our members. we hope you find it helpful.

Best
Peter

To Go to the Information - Click on the Link Below:

Link : "Treating the Cause"
or Go To
http://rvaprostatecancersupport.org/PDF/5 24 21 Stop-Fighting-Cancer-3rd-Edition-compressed.pdf

Us Too Warriors,
My Personal "trial" of Cyclic Testosterone Therapy

This blog describes a brave man who has blazed a path for others by working with his Doctors. It is early in the game but the results look very promising. This is not BAT=Bipolar Androgen therapy because no ADT is Used. It should be called " Monopolar Testosterone therapy".

Best
Peter

To Go to the Information - Click on the Link Below:

Link : "Cyclic"
or Go To
http://rvaprostatecancersupport.org/PDF/5 20 21 My Personal.pdf

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Us Too Warriors,
SBRT - CyberKnife

A member who lives near me will be using SBRT CyberKnife therapy to treat his 3+4 diagnosed PCa soon. I am attaching some Googled information on Herbal supplements that may reduce the side effects and may make it more effective. He will be going to Northern Virginia for treatment(~5 days) and it is also available through Dr. Cuttino at Henrico Doctors.

From what I read the Supplements which may make SBRT more effective, reduce radiation side effects and Online for purchase are: biocurcumin,69–71 resveratrol,72–74 dihydroartemisinin75–77. But most Especially Nitric Oxide like the Snap Inc's Nitric Oxide Booster and LEF's " NitroVasc Boost". These are ones that you can buy onLine. Nitric Oxide acts like Oxygen when radiated and increases blood flow so the oxygen poor regions of the cancer can be damaged by the radiation which are areas where the cancer may be hard to kill with radiation!!!

Best
Peter

Abstract:
Radiotherapy (RT) is a cancer treatment that uses high doses of radiation to kill cancer cells and shrink tumors. Although great success has been achieved on radiotherapy, there is still an intractable challenge to enhance radiation damage to tumor tissue and reduce side effects to healthy tissue. Radiosensitizers are chemicals or pharmaceutical agents that can enhance the killing effect on tumor cells by accelerating DNA damage and producing free radicals indirectly. In most cases, radiosensitizers have less effect on normal tissues. In recent years, several strategies have been exploited to develop radiosensitizers that are highly effective and have low toxicity. In this review, we first summarized the applications of radiosensitizers including small molecules, macromolecules, and nanomaterials, especially those that have been used in clinical trials. Second, the development states of radiosensitizers and the possible mechanisms to improve radiosensitizers sensibility are reviewed. Third, the challenges and prospects for clinical translation of radiosensitizers in oncotherapy are presented.

To Go to the Information - Click on the Link Below:

Link : "CyberKnife"
or Go To
http://rvaprostatecancersupport.org/PDF/5 19 21 ijn-290438-application-of-radiosensitizers-i.pdf

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Us Too Warriors,
The BAD Doctors of The United States (ANTI)Preventive Services Task Force (USPSTF) is a government-funded group

You need to read the below article and send to family and friends. The red text additions are mine.

The BAD Doctors of The United States (ANTI)Preventive Services Task Force (USPSTF) is a government-funded group that claims:
Cross-section of bladder and prostate affected by cancer “to improve (Harm) the health of all Americans by making (False) evidence-based recommendations about clinical preventive services.” recommended against PSA test for PCa in 2012. This resulted in the number of Annual PSA tests dropping from 50% of Men to 30% of men and the age for testing was raised to 55years old to start while families with a history of PCa should start at 40 year. The earlier you Dx Prostate cancer the more likely it is to be dangerous!!

Read and send it to your Sons and Son-in-laws and friends.

Best
Peter

To Go to the Information - Click on the Link Below:

Link : "Bad"
or Go To
http://rvaprostatecancersupport.org/PDF/5 18 21 Bad.pdf

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Us Too Warriors,
Some Anesthisias can phospholate TAU proteins in the brain to increase Alzheimers Disease Development

I have related in past emails that I lost spatial memory for about 5 years after my Prostate Surgery which made it harder for me to navigate around Richmond when driving because I lost the map in my head about how to get to places I knew. The attached paper discusses the problem of Anesthesia leading to Alzheimer's development. Because of my experience of memory problems with anesthesia, I recently had a lymph node under my armpit removed for melanoma cancer with local Lidocaine injections as well as for a cyst on my neck. I was able to find a good surgeon who had treat a pregnant woman with local anesthesia to treat me locally with lidocaine for these surgeries.

Best
Peter

To Go to The Information - Click on the Link Below:

Link 1 : "Anesthisias"
or Go To
https://www.eurekalert.org/pub_releases/2021-05/mgh-ama051221.php
*********************************************
Us Too Warriors,
Blog on Bat

I have not figured them out as each person has a different cancer.

But It looks like it can make Casodex last longer and can also make enzalutamide be reactivated after CRPC in some men.
Best
Peter

(Both Links below are on the same Blog - Different Threads)

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From the Blog:

G’day comrades

I have tried to report my experiences with Bipolar Androgen Therapy (BAT). You will find them in my profile.

This will be the last as the anti androgen I use (bicalutamide) failed in spectacular fashion. I will post on subsequent treatments. The pattern of failure may interest. Hist: Failure of long running ADT (zoladex) was about 2015 when I started bicaulutamide. It failed after 12 months and I decided that was a good time to see what my reaction to BAT might be. All experiences differ but all information is potentially useful. If you have a doc who will prescribe it, then it is a very simple intramuscular injection once a month. You can easily learn to do it yourself (google it).

To Go to The Blog - Click on the Link Below:

Link 1 : "Blog"
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/145582729/end-of-bat-a-few-lessons

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This looks like this is a good treatment for advanced PCa especially for men who have failed different "alutamide" Drugs to make them work again. which will grow as we learn better how to manage it for different men's conditions. E2 skyrockets on BAT therapy
Best
Peter

To Go to The Blog - Click on the Link Below:

Link 2: "Bat"
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/146123113/e2-skyrockets-on-bat-therapy
******************************************
Us Too Warriors,
Relation of TMPRSS2-ERG Fusion Mutation in PCa and Covid 19 is not clear but many interactions seem possible

See the Attached paper on how TMPRSS2 gene may relate to your cancer and Covid-19.??

I learn the following things that apply to between 40 % and 70% of PCa which affect men with TMPRSS2 -ERG PCa:

1. As TMPRSS2-ERG fusion prostate cancer advances it is likely to trigger worse mutations of: P53 negative, Pten negative and Brca 1 & 2 mutations.
2. There is less TMPRSS@-ERG fusion mutation production in the central zone of the prostate than in the peripheral zone of the prostate so growth for men with that area of the prostate should be much slower. My Brother David's cancer is in that area. I and my Brother Don's were at the periphery. David with the help of some of my supplements was not diagnosed with PCa until 26 & 27 years after Me and Don. David is on active surveillance with slow growing PSA with another MRI biopsy in another year - 3+ years from the first.
3. Vcap cell line is TMPRSS2-ERG fusion gene positive and LNCAP cell line is TMPRSS2-ERG fusion gene negative.
4. TMPRSS2-ERG fusion Prostate cancer genes are usually very high in Vitamin D3 receptors-so vitamin D supplement may be a good treatment.
5. TMPRSS2 is used to get the Covid virus into Our body cells to affect the lung etc.
Best
Peter

Abstract:
Members of Coronaviridae family have been the source of respiratory illnesses. The outbreak of SARS-CoV-2 that produced a severe lung disease in afflicted patients in China and other countries was the reason for the incredible attention paid toward this viral infection. It is known that SARS-CoV-2 is dependent on TMPRSS2 activity for entrance and subsequent infection of the host cells and TMPRSS2 is a host cell molecule that is important for the spread of viruses such as coronaviruses.

Different factors can increase the risk of prostate cancer, including older age, a family history of the disease. Androgen receptor (AR) initiates a transcriptional cascade which plays a serious role in both normal and malignant prostate tissues. TMPRSS2 protein is highly expressed in prostate secretory epithelial cells, and its expression is dependent on androgen signals. One of the molecular signs of prostate cancer is TMPRSS2-ERG gene fusion. In TMPRSS2-ERG-positive prostate cancers different patterns of changed gene expression can be detected. The possible molecular relation between fusion positive prostate cancer patients and the increased risk of lethal respiratory viral infections especially SARS-CoV-2 can candidate TMPRSS2 as an attractive drug target. The studies show that some molecules such as nicotinamide, PARP1, ETS and IL-1R can be studied deeper in order to control SARS-CoV-2 infection especially in prostate cancer patients.

This review attempts to investigate the possible relation between the gene expression pattern that is produced through TMPRSS2-ERG fusion positive prostate cancer and the possible influence of these fluctuations on the pathogenesis and development of viral infections such as SARS-CoV-2.

To Go to the Information - Click on the Link Below:

Link : "TMPRSS2-ERG"
or Go To
http://rvaprostatecancersupport.org/PDF/5 16 21 main (1).pdf

Us Too Warriors,
My experience with low dose Doxycycline (100 mg/day) fighting Mets from PCa and Periodontal Disease and now Covid

I have been taking low dose doxycycline for periodontal disease for 14 years to prevent/slow PCa - the mets which are allowed to escape into the body by invadopodia spikes on cancer cells that shoot out Matrix Metallo Proteins that breakdown the extracellular protein collagen that helps to encapsulate the cancer so it is harder to escape to a blood vessel to damage other body organs as a metastasis. These Matrix Metallo Proteins (MMPs) also attack the periodontal ligament that holds teeth to bone to keep them fixed in place. Periodontal infections release MMPs to break down the ligament so that the teeth are loosened and fall out. These same MMPs attack the Dentin of the tooth and turn it into the mush of tooth decay.These same MMPs attack the lungs during Covid and cause blood Clots that kill.

With the use of low dose doxycycline, my periodontal tissue has been excellent - much improved compared to earlier years - no bleeding on brushing, I have all my teeth at 81yrs with only one crown for a cracked tooth. My research in this area over the years has paid dividends for my teeth, cancer and Covid. I was able to make improved bonding treatments for use at the VCU dental school and throughout the world.
Best
Peter

Abstract:
This review describes the relationship between dentin collagen hybrid bond layer degradation and the Matrix Metalloproteinases (MMPs) after their release by acid etch and rinse adhesives and self etching bonding adhesives that can reduce the bond stability over time. MMP-2, MMP-8 and MMP-9 are indicated as the active proteases that breakdown the collagen fibrils in the hybrid bond layer. Phosphoric acid in the acid etch and rinse bonding process and acid primers in the self etch process are implicated in the release of these proteases and their activation by several non-collagen proteins also released from dentin by the etching. MMPs are released in saliva by salivary glands, by cells in the gingival crevices to crevicular fluid and by pulpal odontoblasts cells to the dentinal fluids. These sources may affect the hybrid layer also. Evidence of the bond strength deterioration over time and the ability of Chlorhexidine to prevent bond deterioration by inhibiting MMP action are discussed. Dentin Bonding procedure utilizing Chlorhexidine for different application times and concentrations are being developed. The application of 2% Chlorhexidine to the phosphoric acid etch surface after rinsing off the acid is the only procedure that has been clinically tested for a longer period of time and shown to prevent bond strength degradation so far. The adoption of this procedure is recommended as means of improving bond stability at this time.

To Go to the Information - Click on the Link Below:

Link : "Periodontal Disease"
or Go To
http://rvaprostatecancersupport.org/PDF/5 14 21 TODENTJ-4-147.pdf

Us Too Warriors,
Periodontal disease study tied to 8 times the death rate from Covid

One of the more perplexing things about COVID-19 is its wide range of outcomes in people who get the disease. A new study from researchers at McGill University in Montreal, Canada, finds a link between gums with inflammation and infection and COVID-19 complications and deaths.
Best
Peter

To Go to the Information - Click on the Link Below:

Link : "Periodontal Disease"
or Go To
https://www.medicalnewstoday.com/articles/gum-disease-linked-to-severe-covid-19-outcomes

Us Too Warriors,
Video form Dr. Sallis show Kaiser EXERCISE study reduces Covid hospitalization & death by factor of 4 in 50,000 people studied

The website discusses the results see it and get walking and running for Covid and PCa.
Best
Peter

To Go to the Information - Click on the Link Below:

Link : "EXERCISE"
or Go To
https://www.cnbc.com/2021/04/14/regular-exercise-can-reduce-your-risk-of-severe-covid-study.html

Us Too Warriors,
Focal Ablation Technique for Intermediate-Risk Prostate Cancer Continues to Show Safety Community Cohort Study

This looks interesting for intermediate cancers in a small study But is from the company making the Device.
Best
Peter

To Go to the Information - Click on the Link Below:

Link : "Focal Ablation"
or Go To
http://rvaprostatecancersupport.org/PDF/5 12 21 Focal Ablation Technique for Intermediate.pdf

Us Too Warriors,
Aspirin Use / Prostate Cancer among African-American Men in the Southern Community Cohort Study

Prospective SCCS data suggest that aspirin use may help prevent lethal prostate cancer among this high-risk group of men
Best
Peter

To Go to the Information - Click on the Link Below:

Link : "Aspirin"
or Go To
http://rvaprostatecancersupport.org/PDF/5 8 21 Cohort study of aspirin use among African Americans.pdf

Us Too Warriors,
Jerry Deans and I are gearing up to enjoy life with what we like best!

Jerry is getting ready to get back into scuba diving (after the last 8 years fighting his cancer with help of a master mate to help and look after him after he requalifies himself and his gear he will head down to the Florida Keys. He is taking a time off to enjoy life for now. Bipolar Androgen therapy at John Hopkins may be in his future.

I am adding running to my walking as of tonight with 12 - 30 yard "sprints more like jogs" for now in my 2 mile walks. So in a couple of weeks I can give the young guys I have played against in soccer for the last 25 years a run for their money when I turn 81 years this Month. Keep Smiling and doing what you can.

I am looking for a new Doctor and Chris Maxwell is doing well on Casodex and Metformin with his PSA down about 85% in 5 months. He Had to tell the Doctor he had a hot girlfriend he had to keep happy to get from being debilitated with lupron by the Doctor. He already has a debilitating problem with heat and ADT would have been a killer.
Best
Peter

Us Too Warriors,
I think I have found away to encourage men to use more Vitamin D3

Check out this website if you have ED.

If ED is a problem you may want to read on. Also take vitamin K2 for your bone density to get excess calcium out of blood vessel to prevent hardening of your arteries.
Best
Peter

To Go to the Website - Click on the Link Below:

Link : "ED"
or Go To
https://www.newsmax.com/Health/Dr-Oz/sunlight-vitamin-D-erectile-dysfunction-DrOz/2015/02/24/id/626550/
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Us Too Warriors,
Clinical trials for LU 177 PMSA for hormone sensitive PCa- most in the USA

Check out this website if you have advanced PCa.

Now that the VISION trial of Lu-177-PSMA-617 is no longer recruiting, some patients are wondering if they can still get PSMA-targeted radiopharmaceuticals in the US, without traveling to Germany, Australia, India, etc. Here is a list of trials that are active, still open to recruitment, or will soon be recruiting.
Best
Peter

To Go to the Website - Click on the Link Below:

Link : "Clinical Trial"
or Go To
https://www.prostatecancer.news/2020/08/psma-targeted-radiopharmaceutical.html
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Us Too Warriors,
New Urine Test to determine if you have advance/Aggressive Prostate cancer - Very Helpful for men GS =3+4

This may also help a few of the Gleason Scores =3+3 that end up having aggressive cancer, If you have Gleason score =4+3 or above you are thought to have aggressive cancer. Part of the problem is the biopsy only samples a small fraction of the cancer and the higher Gleason cancers may be missed which means after the primary treatment the cancer progresses and more treatments are needed.
Best
Peter

To Go to the Website - Click on the Link Below:

Link : "Test"
or Go To
https://www.lynxdx.com/my-prostate-score
******************************************
Us Too Warriors,
Black Pepper and Piper Longum fight PC cancer

Black Pepper and Piper Longum fight PC cancer. I added the(Piper Longum) in the last year from a company called "bixa " Botanicals on Amazon as a 70z powder jar. I shake it on my stir fry food. It is not as strong as black pepper so I add more. I have always use a lot of black Pepper ( so now i use both)
Best
Peter

To Go to the Information - Click on the Link Below:

Link 1 : "Pepper 1"
or Go To
http://rvaprostatecancersupport.org/PDF/4 30 21 1-s2.0-S0278691513005498-main (1).pdf
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Link 2 : "Pepper 2"
or Go To
http://rvaprostatecancersupport.org/PDF/4 30 21 nihms391259.pdf
*
Link 3 : "Pepper 3"
or Go To
https://plantmedicines.org/ayurvedic-long-pepper-cancer/
***********************************************************************************
Us Too Warriors,
Black Pepper and Piper Longum fight PC cancer

Black Pepper and Piper Longum fight PC cancer. I added the(Piper Longum) in the last year from a company called "bixa " Botanicals on Amazon as a 70z powder jar. I shake it on my stir fry food. It is not as strong as black pepper so I add more. I have always use a lot of black Pepper ( so now i use both)
Best
Peter

To Go to the Information - Click on the Link Below:

Link 1 : "Pepper 1"
or Go To
http://rvaprostatecancersupport.org/PDF/4 30 21 1-s2.0-S0278691513005498-main (1).pdf
*
Link 2 : "Pepper 2"
or Go To
http://rvaprostatecancersupport.org/PDF/4 30 21 nihms391259.pdf
*
Link 3 : "Pepper 3"
or Go To
https://plantmedicines.org/ayurvedic-long-pepper-cancer/
*****************************************
Us Too Warriors,
Green tea and Mung Bean Turn Off the Cytokine Switch

A biochemical “switch” that turns on many of the chronic diseases of aging has been uncovered. Known as HMGB1, this molecule triggers the release of cytokines—a collection of chemical signals—that generate inflammation in your body. In a hospital setting, researchers have shown that mung bean seed coat and green tea extract counteract HMGB1, safely quelling acute inflammation before it becomes chronic.
Best
Peter

To Go to the Information - Click on the Link Below:

Link : "Cytokine Switch"
or Go To
https://www.lifeextension.com/magazine/2014/1/turn-off-the-cytokine-switch
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Us Too Warriors,
High iron in blood increases PCa growth and may lead to Parkinson's

Iron pathways are complicated as the article below shows. Curcumin and Green Tea are chelators of iron that remove them from the body and may be one of the ways they slow PCa growth.
Best
Peter

To Go to the Information - Click on the Link Below:

Link : "Iron"
or Go To
http://rvaprostatecancersupport.org/PDF/4 27 21 Vela-2018-Iron-metabolism-in-prostate-cancer-.pdf
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Us Too Warriors,
Brainstem and spinal cord dysfunction from androgen deprivation

Another concern for Low T besides heart and bone fractures from ADT. Read blog that follows.
Best
Peter

To Go to the Blog - Click on the Link Below:

Link : "Blog"
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/146006609/brainstem-and-spinal-cord-dysfunction-from-androgen-deprivation
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Us Too Warriors,
Inflammatory diet linked to testosterone deficiency in men

April 21, 2021 - Consuming a diet high in pro-inflammatory foods - including foods that contain refined carbohydrates and sugar as well as polyunsaturated fats - may be associated with increased odds of developing testosterone deficiency among men, suggests a study in The Journal of Urology®, Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.
Best
Peter

To Go to the Website - Click on the Link Below:

Link : "Inflammatory"
or Go To
https://www.eurekalert.org/pub_releases/2021-04/wkh-idl042121.php?utm_medium=email&utm_source=rasa_io&PostID=28974947&MessageRunDetailID=5029550814
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Us Too Warriors,
Blog on NFKb inflammation action on PCa

Read this blog to see how you can fight this Pathway of inflammation that grows PCa
Best
Peter

To Go to the Information - Click on the Link Below:

Link : "Blog"
or Go To
http://rvaprostatecancersupport.org/PDF/4 19 21 Blog.pdf
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Us Too Warriors,
Covid -19 treatment at different stages

Best
Peter

To see the Video - Click on the Link Below:

Link 1 : "Stages"
or Go To
https://www.youtube.com/watch?v=OY8QV7lnFFo
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Us Too Warriors,
Website for an alternative treatment close to mine for your consideration

Website for an alternative treatment that is close to mine, but they add one other drug. So I am taking three of their four (3durgs I take = a Statin(Not their statin), Metformin and doxycycline. I do not take menzbendole but I plan to add a like agent in a few weeks . They do not include the Casodex that has worked for me well for the last 3 years.

They(Their Docs) do everything over the phone and by mail. Last I heard their full consultation cost $270 and The four drugs cost $360 for 3 months. Not Paid by insurance I do not think. See if it makes sense to you if you talk to them for the first time free.

Best
Peter

To Go to the Information - Click on the Link Below:

Link 1 : "Alternative Treatment"
or Go To
https://careoncology.com/the-coc-protocol-in-prostate-cancer/#:~:text=The%20COC%20Protocol%20is%20a,effectiveness%20of%20standard%20anticancer%20therapies
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Us Too Warriors,
Website for an alternative treatment close to mine for your consideration

Website for an alternative treatment that is close to mine, but they add one other drug. So I am taking three of their four (3durgs I take = a Statin(Not their statin), Metformin and doxycycline. I do not take menzbendole but I plan to add a like agent in a few weeks . They do not include the Casodex that has worked for me well for the last 3 years.

They(Their Docs) do everything over the phone and by mail. Last I heard their full consultation cost $270 and The four drugs cost $360 for 3 months. Not Paid by insurance I do not think. See if it makes sense to you if you talk to them for the first time free.

Best
Peter

To Go to the Information - Click on the Links Below:

Link 1 : "Alternative Treatment"
or Go To
https://careoncology.com/the-coc-protocol-in-prostate-cancer/#:~:text=The%20COC%20Protocol%20is%20a,effectiveness%20of%20standard%20anticancer%20therapies
*
Us Too Warriors,
Vitamin K2 is good for heart, brain and ADT lupron treatment which lowers K2 in PCa patients
that will cause Osteoporosis in PCa and doubles the risk of heart attacks.

There are many benefits of Vitamin K2 see below. (Especially if you have APOE4 genes Alzheimer's genes like my family)

Best
Peter

To Go to the Information - Click on the Links Below:

Link 1 : "ADT"
or Go To
http://rvaprostatecancersupport.org/PDF/4 15 21 androgen-deprivation-therapy-induces-vitamin.pdf

Link 2 : "Vit K2"
or Go To
https://lundberginstitute.org/surprise-vitamin-k2-and-cancer/

Link 3 : "Managing prostate cancer metastasis using vitamin k2"
or Go To
https://grantome.com/grant/NIH/R21-CA184646-01A1

Link 4 : "Vit K2 & Alzheimer’s disease"
or Go To
https://www.alzheimers.net/2014-07-09-vitamin-k-alzheimers-prevention
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Us Too Warriors,
What exercises can help reduce love handles?

This website below has simple exercises to remove these fat pads which should be good to fight PCa.

Best
Peter

To go to the Website - Click on the Link Below:

Link : "Love Handles"
or Go To
https://www.medicalnewstoday.com/articles/what-are-love-handles?utm_source=Sailthru%20Email&utm_medium=Email&utm_campaign=MNT%20Daily%20News&utm_content=2021-04-13&apid=27042543&rvid=db97d9a92fcbfbf765e6cd661b725b285374ddc232f43e4263e157b240b215c9
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Us Too Warriors,
Importance of Vitamin D for Covid 19 and Doxycycline for Covid and most everything else

The below Video on Youtube discusses the value of vitamin D Supplementation on fighting long Covid and death.

This is particularly important in dark skin individuals- AA, Latinos and etc (anyone with low vitamin D blood levels ( OHvitamin D3 levels should be 60 to 80ng/ml in blood. I need 12,000+ !U of vitamin D3.per day as I have low Vitamin D absorbing genes only 65%.)

Also, My research in the use of Doxycycline antibiotic (which I take to slow PCa metastasis) shows that it has wide benefit in the inflammation from these diseases:

Tooth decay, Periodontal disease, Heart muscle damage size from heart attacks, stroke damage size in brain, Covid-19 ARDS=Sepesis of the lungs, Chelation of Iron, Aluminum and Manganese ions from the brain to help slow Alzheimer's, Parkinsons and Multiple Sclerosis. Doxycyclines actions are related to stopping MetalloMatrix Proteinase (MMPs) breakdown (damage) of useful proteins structures in the disease area from inflammation,

Best
Peter

To See the Video - Click on the Link Below:

Link : "Vit D"
or Go To
https://www.youtube.com/watch?v=JbLX08eVmIs
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Us Too Warriors,
Long-term Efficacy and Safety of Enzalutamide Monotherapy

Long-term Efficacy and Safety of Enzalutamide Monotherapy in Hormone-naïve Prostate Cancer: 1- and 2-Year Open-label Follow-up Results
Best
Peter

Abstract - Background

Enzalutamide is an androgen receptor inhibitor with a demonstrated overall survival benefit in metastatic castration-resistant prostate cancer. A phase 2 study of enzalutamide monotherapy in patients with hormone-naïve prostate cancer (HNPC) showed a high response rate for the prespecified primary endpoint (ie, prostate-specific antigen [PSA] response at week 25), regardless of metastases at baseline, and favorable tolerability.

To Go to the Information - Click on the Links Below:

Link 1 : "Monotherapy"
or Go To
https://www.sciencedirect.com/science/article/pii/S0302283815000706#:~:text=A%20phase%202%20study%20of%20enzalutamide%20monotherapy%20in,regardless%20of%20metastases%20at%20baseline%2C%20and%20favorable%20tolerability.
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Us Too Warriors,
Nitrosative stress in cancer therapy

Paper below is on NO pathways in Cancer
Best
Peter

To Go to the Information - Click on the Links Below:

Link 1 : "NO pathways"
or Go To
http://rvaprostatecancersupport.org/PDF/4 5 21 994103 (1)-1.pdf
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Us Too Warriors,
Lowering Cholesterol/PCa growth

I have been using prescription statins for about a year. My doctor prescribed Pravastatin (Hydrophilic molecule) which is one of the two best, The other best statin is Pitavastatin (Lipophilic Molecule) See the attached paper. Also, I have been taking Red Rice Yeast supplement, Swanson Inc., a natural source of Atorvastatin for years. I am going to see if my GP Doctor will also prescribe a low dose of Pitavastatin. My dental research experience suggests that using both hydrophobic and hydrophilic statin will be more effective in lowering Cholesterol/PCa growth. Metformin which I have used for 3+ years makes statins more effective! Best Peter A 2nd Paper below discusses how Statins work in PCa,
Best
Peter

To Go to the Information - Click on the Links Below:

Link 1 : "Cholesterol 1"
or Go To
http://rvaprostatecancersupport.org/PDF/4 5 21 vc995759-1.pdf

Link 2 : "Cholesterol 2"
or Go To
https://pubmed.ncbi.nlm.nih.gov/32694690/
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Us Too Warriors,
Phytoestrogen use in Advanced Cancer that maintain the Estrogen receptor
beta active KEEPs EGFR out of the Nucleus to slow PCa

This just published paper describes the need to use phytoestrogens with Finasteride(but probably also Avodart??) in Advanced Cancer to maintain the Estrogen receptor beta active that KEEPs EGFR out of the Nucleus to slow PCa. I have been taking Phytoestrogens with Finasteride and Avodart for years (21years) for years. See Paper attached my email address below!

This attached Paper seems closely tied to the email I sent you a few days ago titled : RVA Us Too- ESTROGEN RECEPTOR beta Inhibits PCa/CRPC forming on ADT!!!!
Best
Peter

To Go to the Information - Click on the Link Below:

Link : "Phytoestrogen"
or Go To
http://rvaprostatecancersupport.org/PDF/4 1 21 Wu-2021-Estrogen-receptor--and-treatment-wi.pdf
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Us Too Warriors,
"BR-DIM" supplement is highlighted as a way to prevent or reverse CRPC especially of enzalutamide resistant

"BR-DIM" supplement is derived from Cruciferous vegetables which we all know are good for fighting PCa. Well finally some clinical trial results are published and attached below. It appears to inhibit the Androgen receptor from going to the nucleus which grows the cancer and keeps short length androgen receptors like ARv-7 away which is on all the time and does not need testosterone to grow PCa..

"BR-DIM" is described as an Androgen receptor Antagonist which is what Enzalutamide and Casodex (which Iuse and it is expected to make them act better and longer. I have been using DIM-plus thru Swanson but I will explore Amazon to see what's available.
Best
Peter

To Go to the Information - Click on the Links Below:

Link 1: "Link 1"
or Go To
http://rvaprostatecancersupport.org/PDF/4 1 21 41598_2020_Article_80519-1.pdf
*
Link 2: "Link 2"
or Go To
http://rvaprostatecancersupport.org/PDF/4 1 21 ajtr0008-0166-1.pdf
*
Link 3: "Link 3"
or Go To
http://rvaprostatecancersupport.org/PDF/4 1 21 4439307.pdf
****************************************************************************************
Us Too Warriors,
ESTOGEN RECEPTOR beta Inhibits PCa/CRPC forming on ADT!!!!

I have known that increasing ESTROGEN RECEPTOR beta and decreasing ESTROGEN RECEPTOR alpha was beneficial in SLOWING PCa.

But a Paper came out today that shows phytoestrogen like Apigenin phytoestrogen, Soy phytoestrogen and Tectogenin phytoestrogen and VPA Drug can increase ESTROGEN RECEPTOR beta to fight CRPC forming on ADT treatment in patients. SEE papers attached.
Best
Peter

To Go to the Information - Click on the Links Below:

Link 1: "Link 1"
or Go To
http://rvaprostatecancersupport.org/PDF/3 29 21 Estrogen.pdf
*
Link 2: "Link 2"
or Go To
http://rvaprostatecancersupport.org/PDF/3 29 21 Estrogen 2.pdf
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Us Too Warriors,
Bipolar Androgen (Testosterone) Therapy and website with John Hopkins Website

I have read that BAT has about 43% response rate in lowering PSA >50%- And it can make Xtandi work again for 30% of men after CRPC failure. It is available at John Hopkins thru a Dr Andrasarkis (SP?) that Jerry Deans is seeing ( among other JH Doctors) and is often used for CRPC but it may be good before CRPC to help with quality of life problems from Lupron ADT, See the Website and Blog below.
See below
Best
Peter

Washington, DC (UroToday.com) Since Huggins’ noble prize-winning work on the role of androgens in prostate cancer progression in 1940, hormonal suppression has been the mainstay of therapy for advanced malignancy. While a flurry of new targets have been discovered over the recent decade, with each sequential therapy, patients face diminishing response rates. Additionally, these medications are associated with a host of side-effects, including decreased focus, fatigue, obesity, decreased bone mass, and sexual dysfunction. Dr. Samuel Denmeade from Johns Hopkins presented a novel approach to castrate-resistant prostate cancer using testosterone to re-sensitize patients to hormonal therapy.

To Go to the Web page - Click on the Link Below:

Link : "Therapy"
or Go To
https://www.urotoday.com/conference-highlights/suo-2019/suo-2019-prostate-cancer/117585-suo-2019-bipolar-ar-therapy.html

Us Too Warriors,
P53 mutation paper and effects in different cancers

Garufi et al., found that capsaicin, the major constituent of peppers, induced mutant p53 degradation and restored wild type p53 functions such as DNA binding and transactivation of target genes [11]. Furthermore, in combination with chemotherapeutic agents, capsaicin induced cell death suggesting that capsaicin-induced p53 reactivation may improve mutp53-carrying cancer cell response to chemotherapy [116].
See below
Best
Peter

To Go to the Information - Click on the Links Below:

Link 1: "Link 1"
or Go To
http://rvaprostatecancersupport.org/PDF/3 27 21 13046_2018_Article_705.pdf
*
Link 2: "Link 2"
or Go To
http://rvaprostatecancersupport.org/PDF/3 27 21 2460353 (1).pdf
*
Link 3 : "Link 3"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228035/
*
Link 4 Vegetables as Good Source on how to fight P53 : "Link 4"
or Go To
https://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/isothiocyanates

******************************************************************************************
Us Too Warriors,
More Glutamine and Glutamate reduction and Diet to fight Cancer

Check out these websites to lower your Glutamine/Glutamate by a spicy diet and Supplements.

I am taking 9 of the 10 supplements to lower Glutamate in the second website. The only one I am not taking is Valerian.
See below
Best
Peter

Anti-Cancer Strategies: Inhibit Glutamine

To Go to the Web pages - Click on the Links Below:

Link 1 : "Strategies 1"
or Go To
hhttps://eatandbeatcancer.com/2017/06/24/anti-cancer-strategies-inhibit-glutamine/
*
Link 2 : "Strategies 2"
or Go To
https://www.canceractive.com/article/glutamine-glutamate-diet-and-cancer

****
Us Too Warriors,
Promising research work at Duke on Glutamine suppression as an alternative to ADT

This sounds interesting. I'm hopeful that it turns out to be a legit therapy.
See below
Best
Peter

The team of Duke Cancer Institute researchers used that finding to propose a treatment strategy that eliminates the need to inhibit the androgen receptor completely. Their goal is to directly target the tumor’s preferred source of fuel – an amino acid called glutamine.

To Go to the Web page - Click on the Link Below:

Link : "Duke"
or Go To
https://corporate.dukehealth.org/news/prostate-cancer-uses-metabolic-switch-thrive-after-hormone-therapy

Us Too Warriors,
FEMA will provide $7000 funeral expenses startin in April 2021 for anyone who die from Covid after Jan 2020

Us Too men, I hope your families have survived this Virus and are getting shots if they have not already gotten them.
See below
Best
Peter

To Go to the FEMA Web page - Click on the Link Below:

Link : "FEMA"
or Go To
https://www.fema.gov/disasters/coronavirus/economic/funeral-assistance

Us Too Warriors,
Radioligand shows benefit over chemotherapy in prostate cancer

PSMA (prostate-specific membrane antigen) -targeted radiopharmaceutical therapy could be more effective and better tolerated than current chemotherapy in patients with metastatic castration-resistant prostate cancer (mCRPC), according to a recent trial.

The Australian study published in the Lancet, compared Lutetium-177 [177Lu]Lu-PSMA-617 (intravenously every six weeks for up to six cycles) with cabazitaxel (20 mg/m2 intravenously every three weeks for up to ten cycles) in 183 men with mCRPC.
See below
Best
Peter

To Read the Paper - Click on the Link Below:

Link : "Radioligand"
or Go To
https://wchh.onlinelibrary.wiley.com/do/10.1002/tre.0030031

Us Too Warriors,
Relation between Nitric Oxide Supplementation, Hormones and TMPRSS2-ERG Mutated PCa

The Moon Brothers have this mutation and that is probably why my Older brothers PSA went down over the last 8 months on nitric oxide supplement after getting off of Xtandi for about 8 months and PSA went from 0.076 to 6.2 with doubling time of less than every two months. His PSa on Nitric Oxide over the last 8 months went from 6.2 to 1.6 and was not doubling!!! He got on Nitric oxide at my suggestion to help walk and prevent falling. On Xtandi he had gotten to the point he needed a cane to walk to prevent falling. Now, he seldom needs a cane. I am building muscle with Nitric Oxide and have double the weight I can lift and the number of repeats I lift over the last year. I suggest you consider testing nitric oxide booster ( from SNAP Inc) for muscle building and prevent falls but check its effect on your PSA after you have used it a short while (a month or two) as I do not know how it will affect other mutations in PCa.
See below
Best
Peter

To Read the Papers - Click on the Link Below:

Link : "Supplementation"
or Go To
http://rvaprostatecancersupport.org/PDF/3 21 21 Mancarella.pdf

Us Too Warriors,
10 way s to Lower PSA Now

10 Things That Lower PSA Levels (And Some Things That Increase It)
See below
Best
Peter

To Read the Papers - Click on the Link Below:

Link : "PSA"
or Go To
https://prostate.net/10-things-lower-psa-levels/

Us Too Warriors,
Study of matrix Metalloproteinases and their inhibitors in prostate cancer

MMPs stands for Matrix Metalloproteinases. They are a group of 26 enzymes which breakdown matrix Collagen proteins in the body including extracellular matrix which encapsulates the PCa tumor to help keep PCa from spreading to the rest of the body organs==>Metastasis.. So things which stop MMPs keep Cancer from spreading. In dentistry it stops dental decay, osteoporosis, and tooth loss from destruction of tooth perio ligaments. In dentistry Doxycycline antibiotic chips are placed in the Tooth sulcus deep pockets to protect the perio ligament from bacteria producing MMPs. I take an off label 100 mg of Doxycycline pill/day for years (a lower dose than antibacterial level to block MMPs in the body to keep PCa from spreading and not kill gut bacteria needed for digestion) .This antibiotic blocks MMP2, 3 and 9. However, I have recently found MMP11 and MMP13 causes cancer to progress so I am looking at ways(supplements) to block MMP 11 & 13. (see attached paper below.. I am also finding evidence that MMP13 also causes the pain and burning in neuropathic pain and blocking them helps recovery from neuropathy. More information to follow as I find it on MMP11 and 13. Casodex and Xtandi may block MMP13.
See below
Best
Peter

To Read the Papers - Click on the Links Below:

Link 1 : "Metalloproteinases"
or Go To
http://rvaprostatecancersupport.org/PDF/3 17 21 Escaff-2010-Study-of-matrix-metalloproteinases-.pdf

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Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Prostate Cancer Progression
Link 2 : "Natural Inhibitors "
or Go To
http://rvaprostatecancersupport.org/PDF/3 17 21 cancers-06-01298.pdf

*********************************************
Us Too Warriors,
How to use MRI for Active Surveillance.

INTRODUCTION
Worldwide, prostate cancer is the second most common cancer diagnosed in men according to data from the GLOBOCAN database. In the United States, it is estimated that prostate cancer will be diagnosed in approximately 248,530 men in the United States in 2021 and account for approximately 34,130 deaths [1].

Although widespread use of serum prostate-specific antigen (PSA) screening of healthy men has resulted in decreases in cancer-related mortality, this benefit has been accompanied by increased detection and treatment of many cancers bearing low metastatic potential (ie, clinically insignificant lesions) [2]. (See "Screening for prostate cancer", section on 'PSA testing'.)
See below
Best
Peter

To Read the Article - Click on the Link Below:

Link 1 : "MRI"
or Go To
https://www.uptodate.com/contents/the-role-of-magnetic-resonance-imaging-in-prostate-cancer#!

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Us Too Warriors,
Nitric Oxide

I told you about my brother, Don (28 year PCa survivor), lowering his PSA after it was at 6.2 after 8 months after being at 0.078 8 months before when he stopped Xtandi. His PSA was doubling every two months when 8 months off Xtandi. He Got off the Xtandi because of the fatigue it caused ( on it for 4 years) and the trouble he had walking. I told him to take "Nitric Oxide Booster " from Snap Inc. to help his muscles so he could walk better at 85 and to fight blood Clots from Covid. But he had the Bonus of his PSA falling from 6.2 to 1.6 over a period of 8 months. The paper attached below says that High NItric Oxide can reduce the androgen receptors to reduce cancer growth and that low nitric Oxide in the blood may make the cancer more likely to grow to become Castration resistant.

My Family has a germline mutation ( TMPRSS2-ERG Mutation) that makes me and my two brothers very susceptible to androgen (Testosterone) causing PCa growth - 50% or more of men are supposed to have this mutation. The Paper that follows suggests that PCa men can benefit from Nitric Oxide Booster to slow PCa.

Jerry Dean is going to try this to see if it helps?? And improve his muscles and fatigue from many rounds of Chemo. I have Found my Muscles are growing at 80 years, especially in my chest to point with my increasing exercise level. They are now bigger than they have ever been and I am now able unscrew jar lids better that I have in the last 30+ years.
See below
Best
Peter

Abstract:
Nitric oxide (NO) is a ubiquitous signaling molecule in the human body with well-known roles in many different processes and organ systems. In cancer, the two-concentrations hypothesis of NO has dictated that low levels of NO are cancer promoting, while high levels of NO are protective against cancer. Although prostate cancer is a hormonally driven malignancy, research has been shifting away from androgen-responsive epithelial cells and evolving to focus on NO therapies, the tumor microenvironment (TME), and inflammation. NO is reported to be able to inhibit activity of the androgen receptor. This may prevent prostate growth, but low levels of NO could conversely select for castration-resistant prostate cells, creating an aggressive cancer phenotype. At high levels, nitrosative stress created from NO overproduction can be protective against prostate neoplasia. In this review, we discuss development and possibilities of NO-based therapies for prostate cancer.

To Read the Paper - Click on the Link Below:

Link 1 : "Nitric Oxide"
or Go To
http://rvaprostatecancersupport.org/PDF/3 17 21 Nitric Oxide.pdf

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Us Too Warriors,
Paper with Topical amitriptyline, ketamine, and lidocaine in neuropathic pain caused by radiation skin reaction

Please find attached a paper which describes some over the counter treatments for Radiation sensitivity.
See below
Best
Peter

To Read the Paper - Click on the Link Below:

Link 1 : "Pain"
or Go To
http://rvaprostatecancersupport.org/PDF/3 15 21 Uzaraga-2012-Topical-amitriptyline-ketamine-and--1.pdf

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Us Too Warriors,
Too New radiation SBRT regime- 5 doses of 9 Grey Versus 1 Dose of 24 Grey Clinical trial results -both ways are Good for intermediate PCa

This Treatment looks promising for men with intermediate PCa (Gleason 3+4) and they will be doing future Clinical trials for men with locally advanced PCa (Gleason+4 +3). This treatment is new so I am seeing if it has any Chance of developing locally in the future.
See below
Best
Peter

To Read the Paper - Click on the Links Below:

Link 1 : "New"
or Go To
http://rvaprostatecancersupport.org/PDF/3 15 21 Greco-2021-Safety-and-efficacy-of-virtual-pros.pdf

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Us Too Warriors,
Curcumin (and Turmeric?) may make radiation treatment for cancer more effective and reduce Side effects

Curcumin is refined from Turmeric but some companies add ingredients that make its absorption in the blood go from 2% for tumeric to 25% or more for Curcumin. I use the life Extension Curcumin Elite (15 pills a day) to fight my PCa.

Curcumin (and Turmeric?) may make radiation treatment for cancer more effective and reduce the Side effects.
See below
Best
Peter

To Read the Paper - Click on the Links Below:

Link 1 : "Curcumin"
or Go To
http://rvaprostatecancersupport.org/PDF/3 14 21 Verma-2016-Relationship-and-interactions-of-cu.pdf

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Us Too Warriors,
Abiraterone for advance cancer with food is Effective

Read the attached paper to save thousands of dollars if you are using Abiraterone to treat PCa.
See below
Best
Peter

To Read the Paper - Click on the Links Below:

Link 1 : "Abiraterone"
or Go To
http://rvaprostatecancersupport.org/PDF/3 12 21 jamaoncology_szmulewitz_2021_vp_200046_1613665902.15309.pdf

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Us Too Warriors,
Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment

If you have been following these emails for a while you know I have put forth the argument that oxidative stress grows cancer and we need to take antioxidant supplements to fight PCa. It now appears that the supplement N-Acetyl Carnitine (NAC) blocks this process so PCa can not feed off of nearby stromal cells like a parasite to get from them Lactic acid/lactate to fuel cancer growth. See the attached paper below.
See below
Best
Peter

To Read the Paper - Click on the Links Below:

Link 1 : "Rewire"
or Go To
http://rvaprostatecancersupport.org/PDF/3 12 21 Martinez-outschoorn-2013-Oncogenes-and-inflammation-rewire-h.pdf

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Us Too Warriors,
Another paper website for NAC supplement below to prevent Metastasis in Advanced PCa.

Best
Peter

Antimetastatic potential of N-acetylcysteine on human prostate cancer cells Abstract:

Abstract Objective: N-acetylcysteine (NAC), is one of the cheapest, safest and widely used over-the-counter-drugs in Thailand. Here the authors examine the antimetastatic potential of NAC on the metastasis of human prostate cancer cells. s unique in targeted cancer therapeutics and will impact the design of human clinical trials

To Go To The Website - Click on the Links Below:

Link 1 : "Website"
or Go To
https://pubmed.ncbi.nlm.nih.gov/23513466/#:~:text=Conclusion%3A%20NAC%20could%20have%20a,primary%20and%20the%20secondary%20tumors

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Us Too Warriors,
Drug for mTor1/2 Bone Mets

The paper attached below is for a new drug tested on mice that blocks both forms of mTor (1/2) which is important because drugs that block only one form of mTor will fail in a short time for PCa.
See below
Best
Peter

Bone metastasis is the leading cause of prostate cancer (PCa) mortality, frequently marking the progression to castration-resistant PCa. Dysregulation of the androgen receptor pathway is a common feature of castration-resistant PCa, frequently appearing in association with mTOR pathway deregulations. Advanced PCa is also characterized by increased tumor heterogeneity and cancer stem cell (CSC) frequency. CSC-targeted therapy is currently being explored in advanced PCa, with the aim of reducing cancer clonal divergence and preventing disease progression. In this study, we compared the molecular pathways enriched in a set of bone metastasis from breast and prostate cancer from snap-frozen tissue. To further model PCa drug resistance mechanisms, we used two patient-derived xenografts (PDX) models of bone-metastatic PCa, BM18, and LAPC9. We developed in vitro organoids assay and ex vivo tumor slice drug assays to investigate the effects of mTOR- and CSC-targeting compounds. We found that both PDXs could be effectively targeted by treatment with the bivalent mTORC1/2 inhibitor Rapalink-1. Exposure of LAPC9 to Rapalink-1 but not to the CSC-targeting drug disulfiram blocked mTORC1/2 signaling, diminished expression of metabolic enzymes involved in glutamine and lipid metabolism and reduced the fraction of CD44+ and ALDEFluorhigh cells, in vitro. Mice treated with Rapalink-1 showed a significantly delayed tumor growth compared to control and cells recovered from the tumors of treated animals showed a marked decrease of CD44 expression. Taken together these results highlight the increased dependence of advanced PCa on the mTOR pathway, supporting the development of a targeted approach for advanced, bone metastatic PCa.

To Read the Paper - Click on the Links Below:

Link 1 : "Bone"
or Go To
http://rvaprostatecancersupport.org/PDF/3 10 21 fonc-10-01012.pdf

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Us Too Warriors,
Zinc Metallochaperones as Mutant p53 Reactivators: A New Paradigm in Cancer Therapeutics

Best
Peter

Abstract:

Restoration of wild-type structure and function to mutant p53 with a small molecule (hereafter referred to as “reactivating” mutant p53) is one of the holy grails in cancer therapeutics. The majority of TP53 mutations are missense which generate a defective protein that is targetable. We are currently developing a new class of mutant p53 reactivators called zinc metallochaperones (ZMCs) and, here, we review our current understanding of them. The p53 protein requires the binding of a single zinc ion, coordinated by four amino acids in the DNA binding domain, for proper structure and function. Loss of the wild-type structure by impairing zinc binding is a common mechanism of inactivating p53. ZMCs reactivate mutant p53 using a novel two-part mechanism that involves restoring the wild-type structure by reestablishing zinc binding and activating p53 through post-translational modifications induced by cellular reactive oxygen species (ROS). The former causes a wild-type conformation change, the later induces a p53-mediated apoptotic program to kill the cancer cell. ZMCs are small molecule metal ion chelators that bind zinc and other divalent metal ions strong enough to remove zinc from serum albumin, but weak enough to donate it to mutant p53. Recently we have extended our understanding of the mechanism of ZMCs to the role of cells’ response to this zinc surge. We found that cellular zinc homeostatic mechanisms, which normally function to maintain free intracellular zinc levels in the picomolar range, are induced by ZMCs. By normalizing zinc levels, they function as an OFF switch to ZMCs because zinc levels are no longer sufficiently high to maintain a wild-type structure. This on/off switch leads to a transient nature to the mechanism of ZMCs in which mutant p53 activity comes on in a few hours and then is turned off. This finding has important implications for the translation of ZMCs to the clinic because it indicates that ZMC concentrations need not be maintained at high levels for their activity. Indeed, we found that short exposures (as little as 15 min) were adequate to observe the mutant p53 reactivating activity. This switch mechanism imparts an advantage over other targeted therapeutics in that efficacy can be accomplished with minimal exposure which minimizes toxicity and maximizes the therapeutic window. This on/off switch mechanism is unique in targeted cancer therapeutics and will impact the design of human clinical trials

To Read the Paper - Click on the Links Below:

Link 1 : "Zinc"
or Go To
http://rvaprostatecancersupport.org/PDF/3 10 21 cancers-10-00166-1.pdf

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Us Too Warriors,
Sesamin inhibits lipopolysaccharide-induced proliferation and invasion through the p38-MAPK and NF-κB signaling pathways in prostate cancer cells

Dr. Prachya Kongthaweelert, deputy associate professor at The Thailand Excellence Center for Tissue Engineering and Stem Cells at Chiang Mai University, said that, while black sesame seeds look simple enough, they have very beneficial properties to those with cancer. He and his team have discovered that extracting “Sesamin,” a natural chemical compound from the seeds, and using it as part of cancer treatment can slow or stop the growth of cancer cells and create an environment in the body that stimulate antibodies, according to Thai PBS.
Best
Peter

Abstract:

Sesamin, a lipid-soluble lignan, is one of the major constituents of sesame. Previous studies have reported that sesamin induces growth inhibition in human cancer cells, particularly prostate cancer cells. In the present study, we mainly explored the mechanism underlying the protective effect of sesamin on prostate cancer cell proliferation and invasion induced by lipopolysaccharide (LPS). We found that the proliferation of PC3 cells, as determined using the MTT assay, and the expression of cyclin D1, COX-2, Bcl-2 and survivin proteins elevated by LPS were distinctly inhibited by sesamin in a dosedependent manner. Meanwhile, the ability of PC3 cell invasion, as determined using the Transwell assay and the expression of matrix metalloproteinase 9 (MMP-9), intercellular adhesion molecule-1 (ICAM-1) and vascular endothelial growth factor (VEGF) proteins increased by LPS were obviously reduced by sesamin in a dose-dependent manner. In addition, the accumulation of TGF-α and interleukin-6 (IL-6) production induced by LPS in the culture supernatant was found to be decreased dose-dependently with sesamin pretreatment in PC3 cells using the enzyme-linked immunosorbent assay (ELISA) kit. Furthermore, phosphorylation of the p38 protein and nuclear factor (NF)-κB activity in the PC3 cells were enhanced by LPS and further inhibited with sesamin, SB203580 pretreatment or p38-siRNA transfection, respectively. Sesamin or SB203580 pretreatment obviously inhibited PC3 cells-derived tumor growth induced by LPS in vivo. Taken together, these results suggest that the potential ability of sesamin to downregulate the secretion of cytokines and the expression of cell proliferative- and invasive-related gene products induced by LPS was shown to be via the p38 mitogen-activated protein kinase (p38-MAPK) and NF-κB signaling pathways, which may be one of the mechanisms of the anticancer activity of this sesamin agent in prostate cancer cells.

To Read the Paper - Click on the Links Below:

Link 1 : "Sesamin"
or Go To
http://rvaprostatecancersupport.org/PDF/3 9 21 or_33_6_3117_PD.pdf

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Us Too Warriors,
Association of Bone Metastatic Burden With Survival Benefit From Prostate Radiotherapy in Patients With Newly Diagnosed Metastatic Prostate Cancer

Best
Peter

IMPORTANCE: Prostate radiotherapy (RT) improves survival in men with low-burden metastatic prostate cancer. However, owing to the dichotomized nature of metastatic burden criteria, it is not clear how this benefit varies with bone metastasis counts and metastatic site.

OBJECTIVE To evaluate the association of bone metastasis count and location with survival benefit from prostate RT.

To Read the Paper - Click on the Links Below:

Link 1 : "Burden"
or Go To
http://rvaprostatecancersupport.org/PDF/3 9 21 jamaoncology_ali_2021_oi_200113_1612551450.8.pdf

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Us Too Warriors,
Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection

Statins and Zinc are good to fight Covid. Best
Peter

Abstract: Background:
Zinc is an essential micronutrient that impacts host–pathogen interplay at infection. Zinc balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases, two groups with an increased risk for severe severe coronavirus disease 2019 (COVID-19) outcomes. We hypothesize that serum zinc content (SZC) influences COVID-19 disease progression, and thus might represent a useful biomarker. Methods: We ran an observational cohort study with 249 COVID-19 patients admitted in Hospital del Mar. We have studied COVID-19 severity and progression attending to SZC at admission. In parallel, we have studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) replication in the Vero E6 cell line modifying zinc concentrations. Findings: Our study demonstrates a correlation between serum zinc levels and COVID-19 outcome. Serum zinc levels lower than 50 µg/dL at admission correlated with worse clinical presentation, longer time to reach stability, and higher mortality. Our in vitro results indicate that low zinc levels favor viral expansion in SARS-CoV-2 infected cells. Interpretation: Low SZC is a risk factor that determines COVID-19 outcome. We encourage performing randomized clinical trials to study zinc supplementation as potential prophylaxis and treatment with people at risk of zinc deficiency.

To Read the Papers - Click on the Links Below:

Link 1 : "Zinc"
or Go To
http://rvaprostatecancersupport.org/PDF/3 9 21 nutrients-13-00562.pdf

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Link 2 : "Statin"
or Go To
http://rvaprostatecancersupport.org/PDF/3 9 21 Statin users 50.pdf

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Us Too Warriors,
Papers on Scanning of PCa for mets etc. resent with papers NOW attached

Check these 2 papers to see when Scanning works WELL. Best
Peter

Abstract:
Prostate cancer–specific positron emission tomography (pcPET) has been shown to detect sites of disease recurrence at serum prostate-specific antigen (PSA) levels that are lower than those levels detected by conventional imaging. Commonly used pcPET radiotracers in the setting of biochemical recurrence are reviewed including carbon 11/fludeoxyglucose 18 (F-18) choline, gallium 68/F-18 prostatespecific membrane antigen (PSMA), and F-18 fluciclovine. Review of the literature generally favors PSMAbased agents for the detection of recurrence as a function of low PSA levels. Positive gallium 68/F-18 PSMA positron emission tomography/computed tomography scans detected potential sites of recurrence in a median 51.5% of patients when PSA level is b1.0 ng/mL, 74% of patients when PSA level is 1.0 to 2.0 ng/mL, and 90.5% of patients when PSA level is N2.0 ng/mL. Review of carbon 11/fludeoxyglucose 18 (F-18) choline and F-18 fluciclovine data commonly demonstrated lower detection rates for each respective PSA cohort, although with some important caveats, despite having similar operational characteristics to PSMA-based imaging. Sensitive pcPET imaging has provided new insight into the early patterns of disease spread, which has prompted judicious reconsideration of additional local therapy after either prostatectomy, definitive radiation therapy, or postprostatectomy radiation therapy. This review discusses the literature, clinical utility, availability, and fundamental understanding of pcPET imaging needed to improve clinical practice. © 2017 The Authors. Published by Elsevier Inc. on behalf of American Society for Radiation Oncology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

To Read the Papers - Click on the Links Below:

Link 1 : "Link 1"
or Go To
http://rvaprostatecancersupport.org/PDF/3 8 21 Zhou2019_Article_ComparisonOfPSMA-PETCTCholi.pdf

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Link 2 : "Link 2"
or Go To
http://rvaprostatecancersupport.org/PDF/3 8 21 PIIS1879850017302060.pdf

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Us Too Warriors,
Antiviral drug 'Molnupiravir' blocks Covid-19 virus within 24 hours: Study

Goods News see the attached website on Oral Drug Test for COVID infected patients clears the virus in a few days - great news may be available in 4 months? Best
Peter

To Go to the Website - Click on the Link Below:

Link : "Molnupiravir"
or Go To
https://health.economictimes.indiatimes.com/news/pharma/antiviral-drug-molnupiravir-blocks-covid-19-virus-within-24-hours-study/79583150

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Us Too Warriors,
Melatonin for bone health and PCa Mets

I have been using Melatonin at 50mg /night and My wife at 80 mg/night for years. See the Paper attached below for its benefit for PCa & bones.
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Melatonin"
or Go To
http://rvaprostatecancersupport.org/PDF/3 7 21 Liu-2021-Melatonin-interrupts-osteoclast-fun.pdf

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Us Too Warriors,
Add Spices to your Diet to Fight cancer

The Slide show Attached below will give you many ideas of Food & Spices you can add to your diet to fight your cancer and make your food taste great too!! You will see in the slides that India and China that make and use the most spices have much less cancer than the USA

My mother, who traveled in China, was very creative in using spices and I followed her lead. What I like about stir fries is I can get everything into the dish and I am looking for more spices as I go to Indian food stores. I found this slide website when trying to see how Sesame Seed might fight PCa. Between my Supplements and spices I may use 50% of agents covered in the slides. But I see I have many more to find and investigate. I hope you find it helpful to see how they fight the inflammation that promotes cancer.

Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Spices"
or Go To
http://rvaprostatecancersupport.org/PDF/3 6 21 19...aggarwal.pdf

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Us Too Warriors,
Polaris Gene Test

Check out this website Below (https://prostatecancernewstoday.com/2021/02/23/prolaris). This gene test test-identifies-higher-risk-patients who can safely-skip- ADT treatment or those should add it to their radition.

It has good information on reducing Mets from 25% to less than 3.9% at 10 years by Adding ADT to Radiation treatment if you are in a high risk Group as shown by this test.

Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Polaris"
or Go To
https://prostatecancernewstoday.com/2021/02/23/prolaris-test-identifies-higher-risk-patients-safely-skip-adt/

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Us Too Warriors,
Treatment with Cabergoline (Dopamine agonist)

I have been using Dostinex prescription (Dr. Meyers recommendation) for about 13 years at 1 or 2 half pills per week. I have not talked about it because I did not know how it worked. But the recent attached paper reports that it can put PCa in remission for men that had ADT - that no longer works which is GREAT so I want you to know about.

I am in the process of sending my Oldest brother (had ADT treatment) an excess of my pills to try to see if they will work for him as he has similar Genes we hope so we will become an N21/2 in the Moon Brother's Clinic Trial. For my next oldest brother, I think I have slowed his cancer by 12 years, as I have him on half my drugs thru his GP Doctor who I talked to for him and they have dropped his PSA several times from 3+ to 1.1 after he was diagnose with high grade PINs ( a precancers condition in 2006).

If you have been or are on ADT treatment read the paper attached paper carefully! You may want may want to get your Prolactin blood level tested to see if you a good candidate for the use of the Drug Dostinex for your PCa. see Paper that follows .
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Cabergoline"
or Go To
http://rvaprostatecancersupport.org/PDF/3 6 21 nihms-1019063.pdf

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Us Too Warriors,
Vit K2

Please find below Paper exposing the Benefits of Vitamin k2 for Bone and advanced PCa health.

Lef.org has a new very high dose Vitamin K2 Supplement (45 mg) which I have just started taking. I had been taking their low dose of K1 and K2 pills for years. The high dose level used in the european studies is very effective and is available from Life extension see below. What is Copied below is the Life Extension article from the 2018 magazine which is on the Virginia Urology website (Will WONDERS NEVER CEASE!!!!)
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Life Extension"
or Go To
https://www.lifeextension.com/vitamins-supplements/item02417/mega-vitamin-k2-high-potency-for-strong-bones?gclid=Cj0KCQiAhP2BBhDdARIsAJEzXlH2Xn1r5Enrol72WyTPKmSrIg6CpyIxn_0OaNtg5JBTq7c2QPjJAnsaAtubEALw_wcB

To go to the Wewbsite - Click on the Link Below:

Link : "Article"
or Go To
https://www.lifeextension.com/magazine/2009/1/vitamin-k-protection-against-arterial-calcification-bone-loss-cancer-aging
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Us Too Warriors,
Rosemary

A Clinical Trial website for Rosemary extract and curcumin that is being planned is: https://clinicaltrials.gov/ct2/show/NCT04403568.

Below is a paper that discusses the action of Rosemary extract on Many cancers including PCa.

Swanson sells a Rosemary extract pill which I will be using - I also have a Rosemary clump in my Garden which I snip off and add to my stir frys.
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Rosemary"
or Go To
http://rvaprostatecancersupport.org/PDF/3 4 21 nutrients-08-00731.pdf

To go to the Wewbsite - Click on the Link Below:

Link : "Clinical Trial"
or Go To
https://clinicaltrials.gov/ct2/show/NCT04403568
*********************************************
Us Too Warriors,
Blog on Bat

I have not figured them out as each person has a different cancer.

But It looks like it can make Casodex last longer and can also make enzalutamide be reactivated after CRPC in some men.
Best
Peter
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From the Blog:

G’day comrades

I have tried to report my experiences with Bipolar Androgen Therapy (BAT). You will find them in my profile.

This will be the last as the anti androgen I use (bicalutamide) failed in spectacular fashion. I will post on subsequent treatments. The pattern of failure may interest. Hist: Failure of long running ADT (zoladex) was about 2015 when I started bicaulutamide. It failed after 12 months and I decided that was a good time to see what my reaction to BAT might be. All experiences differ but all information is potentially useful. If you have a doc who will prescribe it, then it is a very simple intramuscular injection once a month. You can easily learn to do it yourself (google it).

To Go to The Blog - Click on the Link Below:

Link : "Blog"
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/145582729/end-of-bat-a-few-lessons
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Us Too Warriors,
Drug that that can over come ADT of Xtandi resistance when CRPC occurs

Patients with castration resistant prostate cancer (CRPC) usually have a poor prognosis. In part, this is due to the cancer’s ability to resist anti-androgen therapy. A study shows that combining a CPT1A inhibitors with anti-androgen therapy increases the cancer’s sensitivity to the anti-androgen drug enzalutamide.
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "(CRPC)"
or Go To
https://www.sciencedaily.com/releases/2017/05/170515125937.htm
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Us Too Warriors,
New drug being Clinical tested = CC#1477 that Blocks p300 and CBP binding and so does CURCUMIN to fight PCa

P300 and CBP are proteins in PCa cancer cells. When the proteins are bound together and go to the cell nucleus they Grow PCa. Eight years ago I went to a Research seminar at VCU Massey cancer Center by a Doctor from Philadelphia that presented his research that proteins p300 and CBP bind together to form a heterodimer protein group which when it goes to the nucleus it grows the PCa. For this reason, I increased my Super Biocurcumin from LEF.org from 9 pills per day to 15 pills a day which I still take them today. More information on Curcumin below at: https://www.mdpi.com/2218-273X/10/11/1536/htm
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "New drug"
or Go To
http://rvaprostatecancersupport.org/PDF/3 1 21 biomolecules-10-0153.pdf

To go to the Wewbsite - Click on the Link Below:

Link : "CURCUMIN"
or Go To
https://www.mdpi.com/2218-273X/10/11/1536/htm
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Us Too Warriors,
[177Lu]Lu-PSMA-617 vs Cabazitaxel in Patients With Metastatic Castration-Resistant Prostate Cancer

TAKE-HOME MESSAGE

In this phase II trial, 177Lu-PSMA therapy was associated with improved PSA responses compared with cabazitaxel (66% vs 37%) among patients with metastatic castration-resistant prostate cancer and PSMA-positive disease.

These data suggest that 117Lu-PSMA is active and well-tolerated compared with chemotherapy in this patient population.
– Neil Majithia, MD

The patients included in the trial had to have failed a previous abiraterone- or enzalutamide-type novel hormonal agent, and progressive disease at the time of trial entry was required.

Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Lu-PSMA-617 vs Cabazitaxel"
or Go To
https://www.practiceupdate.com/journalscan/78557/67/11?elsca1=emc_enews_weekinreview&elsca2=email&elsca3=practiceupdate_advancedprostatecancer&elsca4=advancedprostatecancer&elsca5=newsletter&rid=NTU2MjE4MTA4NzMS1&lid=20849592
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Us Too Warriors,
Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer

Emergence of an aggressive androgen receptor (AR)-independent neuroendocrine prostate cancer (NEPC) after androgen-deprivation therapy (ADT) is well-known. Nevertheless, the majority of advanced-stage prostate cancer patients, including those with SPINK1-positive subtype, are treated with AR-antagonists. Here, we show AR and its corepressor, REST, function as transcriptional-repressors of SPINK1, and AR-antagonists alleviate this repression leading to SPINK1 upregulation. Increased SOX2 expression during NE-transdifferentiation transactivates SPINK1, a critical-player for maintenance of NE-phenotype. SPINK1 elicits epithelial-mesenchymal-transition, stemness and cellular-plasticity. Conversely, pharmacological Casein Kinase-1 inhibition stabilizes REST, which in cooperation with AR causes SPINK1 transcriptional-repression and impedes SPINK1-mediated oncogenesis. Elevated levels of SPINK1 and NEPC markers are observed in the tumors of AR-antagonists treated mice, and in a subset of NEPC patients, implicating a plausible role of SPINK1 in treatment-related NEPC. Collectively, our findings provide an explanation for the paradoxical clinical-outcomes after ADT, possibly due to SPINK1 upregulation, and offers a strategy for adjuvant therapies.
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "SPINK1"
or Go To
http://rvaprostatecancersupport.org/PDF/2 26 21 s41467-019-14184-0-1.pdf
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Us Too Warriors,
Genomic variations associated with prostate cancer in large cohort of African American men.

Racial disparities in prostate cancer (PCa) incidence and mortality are well known. PCa is known to be more aggressive in African American men (AAM) in terms of higher incidence and mortality rates. Here we validate a tumor gene expression pan-cancer race model in men with PCa and further characterize genomic differences that may contribute to disparate clinical outcomes
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Genomic Variations"
or Go To
https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.6_suppl.20
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Us Too Warriors,
Mutational Drivers of cancer cell migration and invasion

This recent paper below is what we have to stop to fight cancer.
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Mutational Drivers"
or Go To
http://rvaprostatecancersupport.org/PDF/2 24 21 s41416-020-01149-0.pdf
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Us Too Warriors,
"Wormwood" from Swanson is my Source of Artemisinin

See the attached paper on Artemisinin. I also got some Artemisinin seeds to plant when it is warmer (research discovery of Artemisinin and its benefits won a Noble prize in 2015).
Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Artemisinin"
or Go To
http://rvaprostatecancersupport.org/PDF/2 23 21 molecules-21-01331.pdf
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Us Too Warriors,
Paper attached on ways to make P53 negative PCa more able to responded chemotherapy

The paper below looks like it could be helpful.

Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Paper"
or Go To
http://rvaprostatecancersupport.org/PDF/2 23 21 aging-12-103377-1.pdf
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Us Too Warriors,
Beginning of a break thru in Advanced cancer P13K_AKT_mTOR pathways

It has been hard to crack the CODE to stop advanced cancer with P53 or/And P10 Mutations.

We have one member who responded to Rapamycin while having multiple bone mets which treats mTOR pathway which has an mTOR1 and mTOR2 paths that both have to be blocked which worked for him in a John Hopkins Clinical Trial to put him in remission. But he was one of the few to respond. It appears that if you have mutations in P53 or/and P10 you may need to block most or All the P13K_AKT_mTOR pathways. The attached paper discusses the research to try to accomplish this Goal to extend life.

Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Pathways"
or Go To
https://www.urotoday.com/clinical-trials/from-the-editor/126829-pi3k-akt-mtor-inhibitors-for-prostate-cancer-finally-hints-of-a-breakthrough.html#:~:text=PI3K/AKT/mTOR%20Inhibitors%20for%20Prostate%20Cancer%20%E2%80%93%20Finally%20Hints,castration-resistant%20prostate%20cancer.%201,2%20Not%20surprising%20is

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Us Too Warriors,
Statin treatments for Advanced PCa have improved survival

It appears that from the attached paper below that the Lipophilic statin = Pitavastatin is the most effective in preventing PCa deaths and the second best is the Hydrophilic Statin = Pravastatin. I got my GP doctor to prescribe Pravastatin about a year ago as my LDL was higher than it had been. It is now lower, but I may talk to him about Pitavastatin as it is significantly better for PCa survival.

The website below is another paper about statins but it does not have much on pitastatin as there were not many men using it. Best
Peter

To Read The Paper - Click on the Link Below:

Link : "Statin"
or Go To
http://rvaprostatecancersupport.org/PDF/2 21 21 Wu-2019-Mortality-associated-with-statins-i.pdf

To go to the Website - Click on the Link Below:

Link : "Website"
or Go To
https://www.cancernetwork.com/view/statins-associated-lower-all-cause-and-prostate-cancer-mortality
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Us Too Warriors,
Anticancer Properties of Capsaicin Against Human Cancer

Abstract.
There is persuasive epidemiological andexperimental evidence that dietary phytochemicals haveanticancer activity. Capsaicin is a bioactive phytochemical abundant in red and chili peppers. While the preponderance of the data strongly indicates significant anticancer benefitsof capsaicin, more information to highlight molecular mechanisms of its action is required to improve our knowledge to be able to propose a potential therapeutic strategy for use of capsaicin against cancer. Capsaicin has been shown to alter the expression of several genes involved in cancer cell survival, growth arrest, angiogenesis and metastasis. Recently,many research groups, including ours, found that capsaicin targets multiple signaling pathways, oncogenes and tumor-suppressor genes in various types of cancer models. In this review article, we highlight multiple molecular targets responsible for the anticancer mechanism of capsaicin. In addition, we deal with the benefits of combinational use of capsaicin with other dietary or chemotherapeutic compounds,focusing on synergistic anticancer activities.

Best
Peter

To Read - Click on the Link Below:

Link 1 : "Capsaicin"
or Go To
http://rvaprostatecancersupport.org/PDF/2 20 21 PCa-Capsaicin837.pdf

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Us Too Warriors,
Advances in the Treatment of Metastatic Prostate Cancer

Workshop Date and Time

Tuesday, February 23, 2021, 1:30 – 2:30 pm, Eastern Time - Register Now

Registrants can listen in live over the phone or online as a webcast.

Some of The Topics Covered

Overview of the Treatment of Metastatic Prostate Cancer in the Context of COVID-19 -- Advances in the Treatment of Metastatic Prostate Cancer
Updates on the Treatment & Care of Bone Metastases -- The Role of Chemotherapy, Radiation Oncology & Targeted Treatments
The Importance of Clinical Trials, in the Context of COVID-19 -- How Clinical Trials Contribute to Your Treatment Options
The Role of Precision Medicine

Sign up for the conference at Website Link Below.
Best
Peter

To Read Register - Click on the Link Below:

Link 1 : "Website Link"
or Go To
https://www.cancercare.org/connect_workshops/864-advances_in_the_treatment_of_metastatic_prostate_cancer_2021-02-23

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Us Too Warriors,
Vitamin D

You know I have been pushing Vitamin D ( in many forms) as a means of fighting PCa. A recent clinical studies suggest it can prevent 75% of Covid deaths and keep many patients out of THE ICU . See the Video attached to learn more - From Dr. John Campbell on YouTube Best
Peter

To Read Register - Click on the Link Below:

Link 1 : "Vitamin D"
or Go To
https://www.youtube.com/watch?v=oYK9-zvJF_k

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Us Too Warriors,
Join us for our February Events at VCU

Please take advantage (Register) for this VCU seminar on Heart issues as they relate to Covid to help yourself and family.

Best
Peter

To Read Register - Click on the Link Below:

Link 1 : "VCU"
or Go To
http://rvaprostatecancersupport.org/PDF/2 10 21 VCU.pdf

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Us Too Warriors,
TMPRSS2-ERG PCa Mutation

Papers on Celastrol extract from Thunder God Vine works to inhibit the MOON Brothers TMPRSS2-ERG PCa Mutation

This Mutations affects 50% of men with PCa but for David and Peter who we Know have it and Don we Think has this Germline Mutation from our father the paper below provides a possible mode of treatment. i have been using it for about two years. The Thunder God Plant is poisonous but the root if skinned and boil is used to extract the medicine it may be safe but it may be a concern for kidney. (You can Purchase Celastrol on Amazon)

Best
Peter

To Read the Papers - Click on the Links Below:

Link 1 : "Celastrol"
or Go To
http://rvaprostatecancersupport.org/PDF/2 10 21 vbShao-2013-Celastrol-suppresses-tumor-cell-gro.pdf

Link 2 : "Celastrol 2"
or Go To
http://rvaprostatecancersupport.org/PDF/2 10 21 s41598-020-65773-9.pdf

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Us Too Warriors,
Vu Med websites for videos from ASCO 2020 an Advance cancers for men treated in the past with ADT but developed rising PSA

2 websites to check for videos follow in PDF File - You will have to join VU Med.

Best
Peter

To Read the Blog - Click on the Link Below:

Link 1 : "Videos"
or Go To
http://rvaprostatecancersupport.org/PDF/2 9 21 Videos.pdf

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Us Too Warriors,
Blog on necrosis of the Jaw from Bisphosphonates( Prolia or Zomato) use to prevent Osteoporosis (Estrogen Patches Safer)

if on ADT you have to prevent Osteoporosis but Bisposphonates are dangerous for open Jaw infections see Blog Below.

Best
Peter

To Read the Blog - Click on the Link Below:

Link 1 : "Blog"
or Go To
http://rvaprostatecancersupport.org/PDF/2 9 21 Blog.pdf

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Us Too Warriors,
ERG genes that fuses with TMPRSS2 genes promotes advanced aggressive cancers with the P53 and P10 negative Mutations

To stop these dangerous PCa's we need to find a way to knock down the formation of ERG genes that promote their growth!!

My family with theTMPRSS2-ERG Fusion Mutation are prone to this Cancer Gene

Family and friends, The way to fight ERG cancer oncogene is to find agents which will reduce its formation or cause it to disinigrate. I am on the trail of agents to do this, but these oncogene dangers are only recently recognized and its treatment is not fully developed so stay tuned.

The attached papers discusses agents that may accomplish this but at this point I do not recognize any agent that is easily available. It is going to take more research to find one or to locate a paper describing its action.

Best
Peter

To Read the Articles - Click on the Link Below:

Link 1 : "Mutations"
or Go To
http://rvaprostatecancersupport.org/PDF/2 6 21 onc2015109.pdf

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To Read the Articles - Click on the Link Below:

Link 2 : "Nuclear factor kappa B"
or Go To
http://rvaprostatecancersupport.org/PDF/2 7 21 2402482 (1).pdf

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To Read the Articles - Click on the Link Below:

Link 3 : "Vitamin D Receptor"
or Go To
http://rvaprostatecancersupport.org/PDF/2 7 21 Washington-2010--dihydroxyvitamin-d-inhibits-growth.pdf

*******************************************
Us Too Warriors,
P53-MDM2 Mutation blocker natural supplements I take to Fight PCa

I am going to list natural supplements I take to Block the P53-MDM2 mutation which you can research on line to find the papers reporting this by googling the supplement and P53 and MDM2.

The supplements are Apigenin, Berberine, Curcumin, Flucoathin, Feverfew, Tripterygium Wilfordii Hook f. = Thunder god vine = Celastro (also good for arthritis).

In case you wonder why I fight this mutation when my Germline mutation is TMPRSS2-ERG; it is because this P53 negative -MDM2 Somatic Mutation often develops as my germline cancer advances so going on 27 years it is important to prevent Somatic mutations for progressing my cancer.
See Below

Best
Peter
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Us Too Warriors,
Off label Drugs

Off label Drugs for fighting PCa see papers below
See Below

Best
Peter

To Read the Article - Click on the Link Below:

Link : "Off label Drugs"
or Go To
http://rvaprostatecancersupport.org/PDF/2 3 21 Off label Drugs for fighting PCa.pdf

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Us Too Warriors,
Terazosin - Prostate Drug Associated With Lower Risk of Parkinson’s Disease

Terazosin, a medication prescribed to treat enlarged prostate, was associated with a lower risk of developing Parkinson’s disease.
See Below

Best
Peter

To Read the Article - Click on the Link Below:

Link : "Terazosin"
or Go To
https://neurosciencenews.com/prostate-drug-parkinsons-17645/

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Us Too Warriors,
Xtandi VS Lower dose (50mg) Casodex for metastatic hormone sensitive PCa both included ADT Lupron

Paper below Compares to treatments for Xtandi VS Lower dose (50mg) Casodex.

My Brother , Don, used Xtandi and Metformin and ADT prescribed by Doctor Snuffy Myers for 4 years that controlled his cancer at a low PSA (.078) from a value above 10 + at start until the Fatigue last year as side effect became too much and made walking hard ay 84 years so he quite ADT and Xtandi June 2019. His PSA went up to 6.8 in a year (June 2020) at which time I suggested he start taking a "Nitric Oxide Booster by Snap Inc" to fight Covid-19 which turns out to fight PCa too. His PSA after 6 months has dropped to 1.2.

I use Casodex (at higher dose 150mg/day) with metformin and etc etc But NO ADT which dropped my PSA from high 12.2 with multiple mets to a low of 0.0152 June 2020. My PSA has gone up a little in the last 6 Months to 0.056 which initially had a doubling time of every 5 months in October but had slowed to every 12 months in December 2020. So I have had a ride on this treatment for 3 years so far and hope to keep it growing even more slowly for another 3+ years if possible. Casodex has the benefit of preventing bone osteoporosis better than treatments with ADT and not producing fatigue. I also have reduced breast pains with several aromatases and this may keep estrogen out of the Estrogen alpha androgen receptor which may reduce PCa growth too.

I hope this helps. My brother Don has had PCa for 27 years and I have had it for 26 years.

Best
Peter

To Read the Article - Click on the Link Below:

Link : "Xtandi"
or Go To
http://rvaprostatecancersupport.org/PDF/1 30 21 vaishampayan_2021_oi_201051_1611109178.02501 (1).pdf

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Us Too Warriors,
Supplement to restore P53 mutant protein to an anti-cancer fighting protein = Watercress

To Jerry and any other Us too Warriors that have Mutated P53 Proteins affecting the growth of their cancer -Watercress contains the active agent.

This sentence is copied from the paper: " we reported that phenethyl isothiocyanate (PEITC), abundant in watercress, selectively depletes mutant p53, but not wild-type (WT) p53, in a variety of human cancer cell lines [14]" I take Watercress pill (3/d) from Swanson with the hope it will keep my P53 from mutating, but if I knew it was mutated i would take 15 pills/day and buy fresh watercress from a market and eat a bunch every day. In Richmond, http://newgrandmart.com/

This Grand Mart has carried Watercress in the Westend and is found in West Broad Commons Shopping Ctr. at 9040 Broad street.

Best
Peter

To Read the Article - Click on the Link Below:

Link : "Watercress"
or Go To
http://rvaprostatecancersupport.org/PDF/1 22 21 PP-XDI-USA-0219Living Healthy Cookbook with Information about Urologic Cancers-1.pdf

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Us Too Warriors,
Express Scripts a mail order Pharmacy

I use this Pharmacy for all 8 of My prescripts. They cost me only about $7 each.

They do the following former:
1. They email me 2weeks ahead of time to see if I want refill.
2. They contact my Doctor for me if I need a prescription renewal.
3. They cost much less than local prescription Pharmacies like Kroger.
4. They take credit card payments.
5. The pills show up in my mailbox on time before I run out.
6. It is available in Virginia and other states too but you will have to check yours.
See their website to sign up below.

Best
Peter

To Go to the Website - Click on the Link Below:

Link : "Express Scripts"
or Go To
https://www.express-scripts.com/

(Email)
express-scripts-pharmacy@orders.express-scripts.com
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Us Too Warriors,
COVID-19

I got my first Pfizer shot a week ago and I get the second in two weeks. But If you are having trouble finding a shot like I am for My wife - these supplements help to ward off or treat Covid infection see list:
Vitamin D3 ~8,000 IU/day (Good to Take Super Vitamin K (K2) rom Life extension also to put calcium in bones)
Zinc~ 50Mg/day Lactoferrin - 3 Swanson pills/day
Vitamin C~ 6,000 Mg/day
Nitric Oxide Booster- 3 pills/day From Snap Inc.
Brown seaweed -3 pills/day Swanson Inc
These will act to help fight PCa too so I will take them after my second covid shot.
See attached below.

Best
Peter

Impact of chronic exposure to 5-alpha reductase inhibitors on the risk of hospitalization for COVID-19: a case-control study in male population from two COVID-19 regional centers of Lombardy (Italy)

ABSTRACT

Background: There are sex differences in vulnerability to Coronavirus disease 2019 (COVID-19). The coronavirus S protein mediates viral entry into target cells employing the host cellular serine protease TMPRSS2 for S-protein priming. The TMPRSS2 gene expression is responsive to androgen stimulation and it could partially explain sex differences. We hypothesized that men chronically exposed to 5-alpha reductase inhibitors (5ARIs) for benign prostate hyperplasia (BPH) have a lower risk of hospitalization for COVID-19.

Methods: This is a population-based case-control study on consecutive patients positive for SARS-CoV-2 virus who required hospitalization for COVID-19 (cases), age-matched to beneficiaries of the Lombardy Regional Health Service (controls). Data were collected by two high-volume COVID-19 regional centers of Lombardy (Italy). The primary outcome was to compare the prevalence of patients chronically exposed to 5ARIs, who required hospitalization for COVID-19, with the one of controls.

Results: Overall, 943 males were enrolled; 45 (4.77%) were exposed to 5ARI. COVID-19 patients aged >55 years under 5ARI treatment were significantly less than expected on the basis of the prevalence of 5ARI treatment among age-matched controls (5.57 vs. 8.14%; p=0.0083, 95%CI=0.75-3.97%). This disproportion was higher for men aged >65 (7.14 vs. 12.31%; p=0.0001, 95%CI=2.83-6.97%). Eighteen 5ARIs-patients died; the mean age of men who died was higher than those who did not: 75.98±9.29 vs. 64.78±13.57 (p<0.001). Cox-regression and multivariable models did not show correlation between 5ARIs exposure and protection against intensive care unit admission/death.

Conclusions: Men exposed to 5ARIs might be less vulnerable to severe COVID-19, supporting its use in disease prophylaxis.

To Read the Book - Click on the Link Below:

Link : "COVID-19"
or Go To
https://pubmed.ncbi.nlm.nih.gov/33439572/
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Us Too Warriors,
Nutrition and Cancer

See attached paper below.

Best
Peter

ABSTRACT

Nutrition and Cancer

While each person and each cancer diagnosis is unique, general guidance before, during and after treatment includes eating nutritious foods to help focus on healthy habits. When you are healthy, eating enough food may not be a problem. But when you are dealing with cancer and treatment, this may be harder to do. Chemotherapy, surgery, radiation therapy and other cancer treatments may take a toll on the body. They may affect taste, smell, appetite, how much food is eaten and the ability to absorb nutrients from food. This cookbook is designed to help you think about what you eat and to help you select meals while you or someone you love is dealing with cancer. Talk with your physician or care team about cancer treatment, as well as about what to eat during cancer treatment. They may refer you to a dietitian who can help you with your diet and to choose foods and drinks during and after treatment.

To Read the Book - Click on the Link Below:

Link : "Cookbook"
or Go To
http://rvaprostatecancersupport.org/PDF/1 22 21 PP-XDI-USA-0219Living Healthy Cookbook with Information about Urologic Cancers-1.pdf
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Us Too Warriors,
Major Surgery Affects Memory in Individuals with Cerebral Amyloid- Pathology

See attached paper below. I had the experience of having a loss of mental graphical memory of my mental driving map when I drove around Richmond for several years after my Prostatectomy surgery at 54 years when driving around Richmond. It has mostly returned at 80 years, but this is a side effect of the anaesthesia you need to take seriously.

Best
Peter

ABSTRACT

Background: Major surgery has been associated with perioperative neurocognitive disorders (PND), but the contributing factors and long-term prognosis are uncertain. We hypothesize that preclinical Alzheimer’s disease (AD) might predispose to cognitive deterioration after surgery.

Objective: To analyze the effect of amyloid- on the cognitive trajectory after orthopedic surgery in a sample of non-demented subjects.

Methods: Non-demented individuals older than 65 years that were on the waiting list for orthopedic surgery with spinal anesthesia underwent a neuropsychological assessment before and after surgery. During surgery, cerebrospinal fluid samples were obtained to determine AD biomarkers.

To Read the Article - Click on the Link Below:

Link : "Memory"
or Go To
http://rvaprostatecancersupport.org/PDF/1 22 21 jad_2021_79-2_jad-79-2-jad191229_jad-79-jad1.pdf
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Us Too Warriors,
Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression1

My brother like me has the mutation TMPRSS2-ERG in hs PCa. He also has a garden with 50 Tomato plants he harvested his last tomatoes in Early January from his greenhouse. He would put up canned and frozen sauce every year with his wife's help. He has PCa mutation TMPRSS2-ERG Cancers like me. He had Pre cancerous PCa PINs in 1996. But he was diagnosed with cancer until the fall of 2019 with my help with my help getting him to take antioxidants and anti inflammatories and his own love of tomatoes. I was diagnosed in 1994 with PCa in spite of loving tomatoes. I did not eat as much as he did. So read below the paper attached for your information.

Best
Peter

ABSTRACT

Background: There is limited evidence that supports etiologically distinct molecular subtypes of prostate cancer, the identification of which may improve prevention. Given their antioxidant properties, we hypothesized that lycopene and tomato sauce may be especially protective against diseases harboring the common gene fusion transmembrane protease, serine 2 (TMPRSS2):v-ets avian erythroblastosis virus E26 oncogene homolog (ERG).

To Read the Article - Click on the Link Below:

Link 1: "Article"
or Go To
http://rvaprostatecancersupport.org/PDF/1 20 21 Pca- Tomato Lycopene and Tmprss2-erg mutationajcn118703.pdf
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Us Too Warriors,
For Increased Vitamin D Use To Combat COVID-19

Please read the letter below and use the benefits of this knowledge to protect you and your family. Vitamin D is low in people of darker skin color, nursing homes and all during the winter as the Sun is lower in the sky.

Best
Peter

Scientific evidence indicates vitamin D reduces infections & deaths - Dec 7, 2020

To all governments, public health officials, doctors, and healthcare workers,
[Residents of the USA: Text “VitaminDforAll” to 50409 to send this to your state’s governor.]
Research shows low vitamin D levels almost certainly promote COVID-19 infections, hospitalizations, and deaths. Given its safety, we call for immediate widespread increased vitamin D intakes.
Vitamin D modulates thousands of genes and many aspects of immune function, both innate and adaptive. The scientific evidence1 shows that:

To Read the Letter - Click on the Link Below:

Link 1: "Letter"
or Go To
http://rvaprostatecancersupport.org/PDF/1 20 21 Over 200.pdf
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Us Too Warriors,
Lactate and cancer: a “lactatic” perspective on spinal tumor metabolism

Milk break produce can produce Lactate and lactic acid which may be used to grow bone cancers, Some Probiotics species may produce Lactic acid which is bad for PCa growth! This is one of the reasons I avoid milk products and cheese. And I am going to be careful in selecting the probiotics I use.

See statement below copied from a paper on probiotics and a paper attached about cancer mets in the back bone. See below. Best Peter

Bifidobacterium as a genus does not yield D-lactate as a metabolic end product. Some Lactobacillus species do (Table 19.1 in Pot 2014). Among common probiotic Lactobacillus species, the following are classified as species that can produce D-lactic acid: L. acidophilus, L. gasseri, L. delbrueckii subsp. bulgaricus (one of the 2 yogurt starter culture bacteria), L. fermentum, L. lactis, L. brevis, L. helveticus, L. plantarum and L. reuteri. Individual strains within each species may vary with regard to levels of D-lactic acid produced.

Best
Peter

Abstract:

Abstract: Spine tumors are among the most difficult tumors to treat given their proximity to the spinal cord. Despite advances in adjuvant therapies, surgery remains a critical component of treatment, both in primary tumors and metastatic disease. Given the significant morbidity of these surgeries and with other current adjuvant therapies (e.g., radiation, chemotherapy), interest has grown in other methods of targeting tumors of the spine. Recent efforts have highlighted the tumor microenvironment, and specifically lactate, as central to tumorigenesis. Once erroneously considered a waste product that indicated hypoxia/hypoperfusion, lactate is now known to be at the center of whole-body metabolism, shuttling between tissues and being used as a fuel. Diffusion-driven transporters and the near-equilibrium enzyme lactate dehydrogenase (LDH) allow rapid mobilization of large stores of muscle glycogen in the form of lactate. In times of stress, catecholamines can bind muscle cell receptors and trigger the breakdown of glycogen to lactate, which can then diffuse out into circulation and be used as a fuel where needed. Hypoxia, in contrast, is rarely the reason for an elevated arterial [lactate]. Tumors were originally described in the 1920’s as being “glucose-avid” and “lactate-producing” even in normoxia (the “Warburg effect”). We now know that a broad range of metabolic behaviors likely exist, including cancer cells that consume lactate as a fuel, others that may produce it, and still others that may change their behavior based on the local microenvironment. In this review we will examine the relationship between lactate and tumor metabolism with a brief look at spine-specific tumors. Lactate is a valuable fuel and potent signaling molecule that has now been implicated in multiple steps in tumorigenesis [e.g., driving vascular endothelial growth factor (VEGF) expression in normoxia]. Future work should utilize translational animal models to target tumors by altering the local tumor microenvironment, of which lactate is a critical part.

To Read the Paper - Click on the Link Below:

Link 1: "Lactate"
or Go To
http://rvaprostatecancersupport.org/PDF/1 16 21 atm-07-10-220.pdf
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Us Too Warriors,

Natural Agents to add to your amour to block P53 mutation and/or MDM2 binding to P53 you have found in your genes

I am going to suggest some supplement websites that may help with cancer and papers attached to support their use. See Below.

Best
Peter

Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine
Abstract:

The p53 tumor suppressor plays a major role in controlling the initiation and development of cancer by regulating cell cycle arrest, apoptosis, senescence, and DNA repair. The MDM2 oncogene is a major negative regulator of p53 that inhibits the activity of p53 and reduces its protein stability. MDM2, p53, and the p53-MDM2 pathway represent welldocumented targets for preventing and/or treating cancer. Natural products, especially those from medicinal and food plants, are a rich source for the discovery and development of novel therapeutic and preventive agents against human cancers. Many natural product-derived MDM2 inhibitors have shown potent efficacy against various human cancers. In contrast to synthetic small-molecule MDM2 inhibitors, the majority of which have been designed to inhibit MDM2- p53 binding and activate p53, many natural product inhibitors directly decrease MDM2 expression and/or MDM2 stability, exerting their anticancer activity in both p53-dependent and p53- independent manners. More recently, several natural products have been reported to target mutant p53 in cancer. Therefore, identification of natural products targeting MDM2, mutant p53, and the p53-MDM2 pathway can provide a promising strategy for the development of novel cancer chemopreventive and chemotherapeutic agents. In this review, we focus our discussion on the recent advances in the discovery and development of anticancer natural products that target the p53-MDM2 pathway, emphasizing several emerging issues, such

To Read the Paper - Click on the Link Below:

Link 1: "Natural Products"
or Go To
http://rvaprostatecancersupport.org/PDF/1 13 21 Natural products targeting the p53-MDM2 main.pdf
***************

Fucoxanthin and Its Metabolite Fucoxanthinol in Cancer Prevention and Treatment
See Below

ABSTRACT
Fucoxanthin is a carotenoid present in the chloroplasts of brown seaweeds. When ingested, it is metabolized mainly to fucoxanthinol by digestive enzymes of the gastrointestinal tract. These compounds have been shown to have many beneficial health effects, including anti-mutagenic, anti-diabetic, anti-obesity, anti-inflammatory and anti-neoplastic actions. In every cancer tested, modulatory actions of fucoxanthinol on viability, cell-cycle arrest, apoptosis and members of the NF-κB pathway were more pronounced than that of fucoxanthin. Anti-proliferative and cancer preventing influences of fucoxanthin and fucoxanthinol are mediated through different signalling pathways, including the caspases, Bcl-2 proteins, MAPK, PI3K/Akt, JAK/STAT, AP-1, GADD45, and several other molecules that are involved in cell cycle arrest, apoptosis, anti-angiogenesis or inhibition of metastasis. In this review, we address the mechanisms of action of fucoxanthin and fucoxanthinol according to different types of cancers. Current findings suggest that these compounds could be effective for treatment and/or prevention of cancer development and aggressiveness.

Link 2: "Brown Seaweeds"
or Go To
http://rvaprostatecancersupport.org/PDF/1 13 21 Martin-2015-Fucoxanthin-and-its-metabolite-fuco.pdf

Source Website:
"Gambogic acid, a natural xanthone, has been reported to inhibit MDM2 at both the transcriptional and posttranslational levels and exerts anticancer activity in vitro and in vivo, regardless of the p53 status of the cells/tumors.62 "
Source of Garcinia:

Link 3: "Garcinia"
or Go To
https://www.iherb.com/pr/Now-Foods-Garcinia-1-000-mg-120-Tablets/55359

Source Website:
"Fucoxanthin (27), a natural carotenoid, inhibits cell growth and colony formation, induces cell cycle arrest at the G0/G1 phase, and leads to apoptosis in T24 bladder cancer cells. 109 Fucoxanthin inhibits the mortalin-p53 complex and reactivates mutant p53 in these cells, resulting in the upregulation of p21. The crude extract of turmeric (Curcuma longa) and its bioactive component, curcumin, have been found to induce apoptosis and autophagy in A431 epidermoid cancer cells, which express mutant p53 R273H.110 Both turmeric and curcumin induce macroautophagy, resulting in the degradation of mutant p53. (You know how I love Curcumin at 15 pills a day. And In the past i have dropped my PSa taking 3 pills of Fucoxanthin a day)
Source of Fucoidan:

Link 4: "Fucoidan"
or Go To
https://www.swansonvitamins.com/swanson-greenfoods-formulas-pure-maximum-strength-fucoidan-extract-500-mg-60-veg-caps

Source Website:
"Fucoxanthin (27), a natural carotenoid, inhibits cell growth and colony formation, induces cell cycle arrest at the G0/G1 phase, and leads to apoptosis in T24 bladder cancer cells.109 Fucoxanthin inhibits the mortalin-p53 complex and reactivates mutant p53 in these cells, resulting in the upregulation of p21. The crude extract of turmeric (Curcuma longa) and its bioactive component, curcumin, have been found to induce apoptosis and autophagy in A431 epidermoid cancer cells, which express mutant p53 R273H.110 Both turmeric and curcumin induce macroautophagy, resulting in the degradation of mutant p53. (you know how I love Curcumin at 15 pills a day. And In the past i have dropped my PSa taking 3 pills of Fucoxanthin a day)
Source of Fucoxanthin :

Link 5: "Fucoxanthin"
or Go To
hthttps://www.luckyvitamin.com/p-13164-garden-of-life-fucothin-concentrated-fucoxanthin-90-softgels?LanguageCode=EN&locale=en-US&as=nd&scid=scplp62303&sc_intid=62303&utm_campaign=LV-US-ShoppingCampaign-SmartShopping-TopBrands&gclid=Cj0KCQiArvX_BRCyARIsAKsnTxMvwU2DzLiiv7R0k_MN5p5-u3rSwruIrtEs07H5pXSwpTG6oFnb4LoaAmvNEALw_wcB

Difference Between Fucoidan and Fucoxanthin - Website Info:

Link 6: "Difference"
or Go To
https://www.differencebetween.com/difference-between-fucoidan-and-fucoxanthin/#:~:text=The%20key%20difference%20between%20fucoidan,brown%20algae%20and%20other%20heterokontshttps://www.luckyvitamin.com/p-13164-garden-of-life-fucothin-concentrated-fucoxanthin-90-softgels?LanguageCode=EN&locale=en-US&as=nd&scid=scplp62303&sc_intid=62303&utm_campaign=LV-US-ShoppingCampaign-SmartShopping-TopBrands&gclid=Cj0KCQiArvX_BRCyARIsAKsnTxMvwU2DzLiiv7R0k_MN5p5-u3rSwruIrtEs07H5pXSwpTG6oFnb4LoaAmvNEALw_wcB
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Us Too Warriors,

Vitamin K2

I have often recommended that members supplement with Vitamin K2 with their Vitamin D2 to prevent hardening of yours of Arteries and its attendant heart disease. I take 3 pills a day of Life Extension Super K with its Vitamin K2 present. The YouTube Video below discusses the need and uses of Vitamin K2 for your information.

Best
Peter

Abstract:

To See the Video - Click on the Link Below:

Link 1: "Vitamin K2"
or Go To
https://www.youtube.com/watch?v=BvGssM-X-Lg&feature=youtu.be
*
Articles:

It Appears that Vitamin K2 can slow cancer especially bone Metastasis. Life extension has just put out a high dose Vitamin K2 pill with about 45 the dose of their Super Vitamin K2 that I have been taking for years. This may turn out to be a way to fight bone metastasis in prostate cancer! I am just beginning to investigate this stay tuned
See Below

ABSTRACT
Epidemiological studies have demonstrated a relationship between cancer incidence and dietary habits. Especially intake of certain essential nutrients like vitamins has been shown to be beneficial in experimental studies and some clinical trials. Vitamin K (VK) is an essential nutrient involved in the blood clotting cascade, and there are considerable experimental data demonstrating its potential anticancer activity in several cancer types including prostate cancer. Previous in vitro and in vivo studies have focused mainly on anti-oxidative effects as the underlying anticancer mechanism of VK. However, recent studies reveal that VK inhibits the growth of cancer cells through other mechanisms, including apoptosis, cell cycle arrest, autophagy, and modulation of various transcription factors such as Myc and Fos. In the present review, we focus on the anticancer effect of dietary VK and its analogs on prostate cancer, with an emphasis on the signaling pathways that are activated following exposure to these compounds. This review also highlights the potential of VK and its derivatives as an adjuvant treatment in combination with other vitamins or with chemotherapeutic drugs. Based on our recent results and a review of the existing literature, we present evidence that VK and its derivatives can potentially be explored as cancer therapy, especially for prostate cancer.

Link 2: "Vit K"
or Go To
http://rvaprostatecancersupport.org/PDF/1 13 21 Dasari-2017-Vitamin-k-and-its-analogs-potential (1).pdf

ABSTRACT
In recent years, several studies have shown that vitamin k2 (VK2) has anticancer activity in a variety of cancer cells. The antitumor effects of VK2 in prostate cancer are currently not known. In the present study, we sought to characterize the anticancer potential of VK2 in both androgen-dependent and -independent prostate cancer cells. Our investigations show that VK2 is able to suppress viability of androgen-dependent and androgen-independent prostate cancer cells via caspase-3 and -8 dependent apoptosis. We also show that VK2 treatment reduces androgen receptor expression and PSA secretion in androgen-dependent prostate cancer cells. Our results also implicate VK2 as a potential anti-inflammatory agent, as several inflammatory genes are downregulated in prostate cancer cells following treatment with VK2. Additionally, AKT and NF-kB levels in prostate cancer cells are reduced significantly when treated with VK2. These findings correlated with the results of the Boyden chamber and angiogenesis assay, as VK2 treatment reduced cell migration and angiogenesis potential of prostate cancer cells. Finally, in a nude mice model, VK2 administration resulted in significant inhibition of both androgen-dependent and androgen-independent tumor growth. Overall, our results suggest that VK2 may be a potential therapeutic agent in the treatment of prostate cancer.

Link 3: "Vit K"
or Go To
http://rvaprostatecancersupport.org/PDF/1 13 21 Samykutty-2013-Vitamin-k-a-naturally-occurring-men.pdf
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Us Too Warriors,

Cortisol and Health-related Quality of Life as Prognostic Indicators for Prostate Cancer
Risk in West African Black Men in Nigeria, Cameroon and the USA:
The CaPTC Cohort Study

Life stressed increase Cortisol which Grows PCa see attachments below. For those of you who have been members for a while will remember Jerry Deans leading several of our meetings to teach us on how tho lower stress by relaxing and breathing deeply while we repeated a montra to ourselves as we breathe deeply in and out with our eyes closed. I have been using this for about 14 years since Jerry first introduced our group to it. This produces a physiological process in our body called the "stress relaxation response". I have studied this Response and found that this can also be produced by a Life extension supplement extracted from green tea called "L-Theanine" ( Enhanced Stress Relaxation pills). I Have had my wife using these pills for years as she is very hyper and jumps if I walk into the room too Quietly.

Stress has been very bad for her fibromyalgia which I think my cancer diagnosis greatly exaggerated. We have only started to get a handle on it by her adding CBD hemp oil to treatment in the last year or two.

Read the attached paper below and figure out how you can reduce stress to slow your cancer.

Best
Peter

Abstract:

More Info - Click on the Link Below:

Link 1: "Cortisol"
or Go To
http://rvaprostatecancersupport.org/PDF/1 11 21 116-Article Text-1398-3-10-20210104.pdf
*
Us Too Warriors,

Melatonin (high dose) prevents Hospitalization & death from Covid-19

The Below website was sent to me by one of my dental Colleagues It is a video which credits a Doctor Neel in texas of treating 1000 of his patients with high dose vitamin d and and high dose Melatonin and none of them had to be hospitalized to treat the Covid... I take about 40mg/night and My wife 80mg. and I take 15,000 IU of Vitamin d and My wife takes 10,000 IU of vitamin D

The attached paper below explains how these drugs work to control the PSA - read them for your benefit.

Best
Peter

Abstract:

More Info - Click on the Links Below:

Link 1: "Melatonin"
or Go To
http://rvaprostatecancersupport.org/PDF/1 7 21 27757-1060170-1-PB.pdf

Link 2: "Website"
or Go To
https://www.bing.com/videos/search?q=russel+reiter+melatonin&qpvt=russel+reiter+melatonin&FORM=VDRE
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Us Too Warriors,

50% Of Pca MEN Have The TMPRSS2-ERG Mutation – That I Have

The treatment that I found for my mutation by trial and error from research papers may work for you if you have this mutation (which 50% or more have as shown by several analysis from several gene analysis that show it is the most common mutation). It tends to make the cancer more aggressive. When the cancer is at early stages, Avodart(dutasteride = .5mg/day ) will be enough slow the PSA which work for me for 15 years after I had biochemical recurrence after my prostatectomy (and my PSA was less than 1.0 (actually at PSA = 0.3). it is still working for one of my brothers with this family germline mutation.

After your PSA goes above 1.0 while on dutasteride it (PSA) will start rising faster and faster and at this point you need to add Casodex(bicalutamide =150 mg/day) the androgen receptor blocker to drive your PSA down.

The two attached papers below explain how these drugs work to control the PSA - read them for your benefit.

Best
Peter

Abstract:

Role of Dutasteride in Pre-Clinical ETS Fusion-Positive Prostate Cancer Models

and

Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer

More Info - Click on the Links Below:

Link 1: "Dutasteride"
or Go To
http://rvaprostatecancersupport.org/PDF/1 6 21 22509_ftp.pdf

Link 2: "Estrogen-dependent"
or Go To
http://rvaprostatecancersupport.org/PDF/1 6 21 nihms272096.pdf
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Us Too Warriors,

Treatments for Anemia when you Have Prostate cancer?

I am trying to give one of my brothers advice to increase his Blood Hematocrit without causing other problems. He has lowered kidney function which is important in producing blood cells. There are drugs to stimulate blood cell formation like Procrit and Epo but they contribute to strokes and heart problems and Prostate cancer growth. and are only used for quality of life for PCa men on hospice.

His PCa seems to be slowed in growing by many of the things that I take and we have the same TMPRSS2-ERG fusion Gene so they seem to be working as his PSA with a prostate is only 1.4 at 82 years.

My expectation is that his low testosterone ~200 may be contributing to his poor kidney function and anemia. So I think he should check with his Doctors to see if he can get testosterone cream to rub on his body to raise his testosterone to 450 to 550. This should help his kidney function and reduce anemia. The concern is that the testosterone may increase his cancer growth but with a testosterone of 200 it is high enough to saturate his cancer cell so the increase would have little effect. But I would recommend he double his dose of Avodart or add proscar to his present dose of avodart whichever he can get his Doctor to Do? This will keep his Dihydrotestosterone low so as not stimulate PCa.

See the two websites attached for more information.

Best
Peter

Abstract:

Erythropoiesis-Stimulating Agents Recommended for Some Patients With Cancer and Anemia

and

Blood Disorders (Anemia, Leukopenia, and Thrombocytopenia)

More Info - Click on the Links Below:

Link 1: "Erythropoiesis-Stimulating"
or Go To
https://ascopost.com/issues/may-25-2019/erythropoiesis-stimulating-agents-recommended-for-some-patients-with-cancer-and-anemia/
*
Link 2: "Blood Disorders"
or Go To
https://www.lifeextension.com/protocols/heart-circulatory/blood-disorders
*******************************************
Us Too Warriors,

Arvinas Releases Updated Dose Escalation Data from Clinical Trial of PROTAC® Protein Degrader ARV-110 in Patients with Metastatic Castration-Resistant Prostate Cancer

See the link below for more information.

Best
Peter

Abstract:

NEW HAVEN, Conn., May 29, 2020 (GLOBE NEWSWIRE) -- Arvinas, Inc. (Nasdaq: ARVN), a clinical-stage biotechnology company creating a new class of drugs based on targeted protein degradation, today announced updated data from the dose escalation portion of the company’s Phase 1/2 clinical trial of ARV-110 in men with metastatic castration-resistant prostate cancer (mCRPC), to be shared as an oral presentation at the 2020 American Society of Clinical Oncology (ASCO) Annual Meeting on May 29, 2020. ARV-110 is a potent, selective, orally available androgen receptor (AR) degrader, and the ASCO presentation highlights promising clinical activity, including both efficacy and AR degradation, in a heavily pretreated patient population.

“For ARV-110 to show signs of efficacy in these patients at this early stage of development is strong validation of our PROTAC® technology,” said John Houston, Ph.D., President and Chief Executive Officer at Arvinas. “In addition, seeing AR degradation demonstrates that ARV-110 is acting on-mechanism to achieve this result, and we are excited to continue clinical development in the hope of bringing a new therapeutic option to patients with significant unmet need.”

More Info - Click on the Links Below:

Link: "Clinical Trial"
or Go To
https://ir.arvinas.com/news-releases/news-release-details/arvinas-releases-updated-dose-escalation-data-clinical-trial/
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Us Too Warriors,

Therapeutic Potential of Leelamine, a Novel Inhibitor of Androgen Receptor and Castration-Resistant Prostate Cancer

See the link below for more information.

Best Holiday
Peter

Abstract:

Clinical management of castration-resistant prostate cancer (CRPC) resulting from androgen deprivation therapy remains challenging. CRPC is driven by aberrant activation of androgen receptor (AR) through mechanisms ranging from its amplification, mutation, post-translational modification, and expression of splice variants (e.g., AR-V7). Herein, we present experimental evidence for therapeutic vulnerability of CRPC to a novel phytochemical,leelamine (LLM), derived from pine tree bark. Exposure of human prostate cancer cell lines LNCaP (an androgen-responsive cell line with mutant AR), C4-2B (an androgen-insensitive variant of LNCaP), and 22Rv1 (a CRPC cell line with expression of AR-Vs), and a murine prostate cancer cell line Myc-CaP to plasma achievable concentrations of LLM resulted in ligand-dependent (LNCaP) and ligand-independent (22Rv1) growth inhibition in vitro that was accompanied by downregulation of mRNA and/or protein levels of full-length AR as well as its splice variants including AR-V7. LLM treatment resulted in apoptosis induction in the absence and presence of R1881. In silico modelling followed by luciferase reporter assay revealed a critical role for non-covalent interaction of LLM with Y739 in AR activity inhibition. Substitution of the amine group with an isothiocyanate functional moiety abolished AR and cell viability inhibition by LLM. Administration of LLM resulted in 22Rv1 xenograft growth suppression that was statistically insignificant but was associated with a significant decrease in Ki-67 expression, mitotic activity, expression of full-length AR and AR-V7 proteins, and secretion of prostate-specific antigen. The present study identifies a novel chemical scaffold for the treatment of CRPC.

More Info - Click on the Links Below:

Link: "Leelamine"
or Go To
http://rvaprostatecancersupport.org/PDF/1 1 21 Singh-2018-Therapeutic-potential-of-leelamine-.pdf

Link: "Ashwagandha"
or Go To
http://rvaprostatecancersupport.org/PDF/1 2 21 Dutta-2019-Withania-somnifera-ashwagandha-and-.pdf

Link: "Isoliquiritigenin"
or Go To
http://rvaprostatecancersupport.org/PDF/1 2 21 T200800068.pdf
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Us Too Warriors,

Turmeric in Combination with Quercetin

One of the ways PCa progresses on ADT or on Androgen receptor blocking Mono Therapy like Casodex or in combined ADT and Xtandi is by the cancer increasing the number of Androgen receptors (This is caused making a bigger Sail so even low Testosterone grows the cancer).

I have recently read that testosterone in Turmeric in combination with quercetin helps to block this process. I have started to have some growth in my Casodex monotherapy so I added more Turmeric and Quercetin to my treatments to stop the growth.

Best Holiday
Peter

Abstract:

Cancer is a hyperproliferative disorder that is usually treated by chemotherapeutic agents that are toxic not only to tumor cells but also to normal cells, so these agents produce major side effects. In addition, these agents are highly expensive and thus not affordable for most. Moreover, such agents cannot be used for cancer prevention. Traditional medicines are generally free of the deleterious side effects and usually inexpensive. Curcumin, a component of turmeric (Curcuma longa), is one such agent that is safe, affordable, and efficacious. How curcumin kills tumor cells is the focus of this review. We show that curcumin modulates growth of tumor cells through regulation of multiple cell signaling pathways including cell proliferation pathway (cyclin D1, c-myc), cell survival pathway (Bcl-2, Bcl-xL, cFLIP, XIAP, c-IAP1), caspase activation pathway (caspase-8, 3, 9), tumor suppressor pathway (p53, p21) death receptor pathway (DR4, DR5), mitochondrial pathways, and protein kinase pathway (JNK, Akt, and AMPK). How curcumin selectively kills tumor cells, and not normal cells, is also described in detail.

More Info - Click on the Link Below:

Link: "Combination"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758121/
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Us Too Warriors,

Neem

Neem is my Latest addition to help my PCa Fight

Best Holiday
Peter

NEEM/AND ITS COMPONENTS AS EFFECTIVE AGENTS FOR PREVENTION, TREATMENT AND CELL DEATH, FOR PCA, AND OTHER CANCERS.

The 2 main components of Neem that are active against cancer, are Azadirachtin, and Nimbolia. I am doing below my research summarization. And for those that want to study these compounds and Neem can find lots to read in Pub Med, Science Direct et. al. and I do not copy and paste.

Usually Ethanolic extracts of Indian Neem Leaf are what are used in the study of the effects on cancer cell lines. Yes Prostate included. Natives of India have use the Neem Leaf for 400 years, and the local Herbalists, over many decades regularly treat cervical cancer with Neem Preparations.

More Info - Click on the Links Below:

Link 1: "Neem"
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/144946771/neem-and-its-components-as-effective-agents-for-prevention-treatment-and-cell-death-for-pca-and-other-cancers.#post-responses
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Link 2: "Gov-Link Neem"
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682706/
*
Link 3: " Sloan Kettering Cancer Center-Link Neem"
or Go To
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/neem
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Us Too Warriors,

How to get the benefit of Rapamycin and Metformin By using Natural supplement

See the link below so you do not have to ask your Doctors for the prescription to fight your cancer but can use natural supplement Mimics instead

Best Holiday
Peter

More Info - Click on the Link Below:

Link: "Supplement"
or Go To
http://rvaprostatecancersupport.org/PDF/12 30 20 CreFziTch9NfHnRyp.pdf
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Us Too Warriors,

COVID-19 vaccine hope for older adults: following release of AstraZeneca, Pfizer, Moderna clinical trial data

It is not easy to compare Moderna and Pfizer vaccines for effectiveness with age but I think Moderna claims an 86% for over 65years WITH NOT MUCH DISCUSSION WITH OVER 80 YEARS. With a number of temporary but uncomfortable reactions for a few days but no allergic reactions. Pfizer claims about 94 % effectiveness for this older age range. There seems to be more involved allergy reaction with the Pfizer vaccine in a few cases and the reactions accrue more at the second shot. You might expect to take the day to rest after the second shots. The first shot gives some protection. Read for yourself to decide which shot you prefer if you have a choice.

Best Holiday
Peter

More Info - Click on the Link Below:

Link: "Vaccine"
or Go To
https://www.biopharma-reporter.com/Article/2020/11/23/COVID-19-vaccine-hope-for-older-adults-AstraZeneca-Pfizer-Moderna-trial-data?utm_source=copyright&utm_medium=OnSite&utm_campaign=copyright
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Us Too Warriors,

Could chocolate or green tea fight Covid-19? NC State researchers think it's possible

I have been taking 9 pills/day of Super Green Tea Extract( lightly caffeinated) from Life Extension Inc for about 15 years for PCa as a strong antioxidant. (These pills are probably equal to 30 to 60 cups of tea/day). The website below from N.C. State Researchers suggest this is a good combination with Dark chocolate to fight Covid-19. It is a very enjoyable way to fight covid especially if your Brother has sent you a Dark Chocolate with Hazelnut bar as he did for Christmas (and if your favorite nuts are Hazel Nuts like me). Enjoy your holiday in good health,

I pray.

Peter

New research coming out of N.C. State says that certain foods, including dark chocolate and green tea, may be inhibitors to the virus that causes Covid-19.

This week, new research was published in Frontiers in Plant Sciencedetailing work from a team of plant biologists at N.C. State regarding how certain chemical compounds in food and beverages may interact with the virus. Researchers analyzed how compounds found in certain foods could bind to and block the function of a specific enzyme – or protease – in the virus, which could inhibit it in a number of ways including slowing its replication.

For Much More Info - Click on the Link Below:

Link: "Chocolate "
or Go To
https://www.bizjournals.com/triangle/news/2020/12/01/covid-diet-fight-virus-chocolate-green-tea-grapes.html
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Us Too Warriors,

Natural Health Healing like nasal lavage and gargle can fight getting and spreading

Check the website below about ways to help you.

Best Holiday
Peter

The Journal of the American Medical Association (JAMA) is among the most widely respected medical journals in the world. In July, it published a collaborative research paper looking at nasal irrigation and its hypothetical effects on the coronavirus. The analysis was written by scientists at the Washington University School of Medicine and Oregon Health & Science University.2

It was titled: Benefits and Safety of Nasal Saline Irrigations in a Pandemic—Washing COVID-19 Away.3

Can you actually “wash away” the coronavirus?

For Much More Info - Click on the Link Below:

Link: "Natural Health Healing "
or Go To
https://www.institutefornaturalhealing.com/issues/ih_october2020.html?bsft_eid=ada17c73-9711-0932-5e68-50c9fa120466&bsft_aaid=125df99d-f163-4437-b900-29fafdc6a7e6&utm_campaign=12-23-20-thc-dedicated-engagement-effort1&utm_source=blueshift&utm_medium=email&utm_content=12-23-20-thc-dedicated-engagement-effort1&bsft_clkid=f1a83a7e-0db8-4914-8149-2347b076c251&bsft_uid=0131f227-755f-4690-a6df-f7d7c78c0773&bsft_mid=97a3f152-5dda-4865-89cb-b7765259a20f&bsft_utid=0131f227-755f-4690-a6df-f7d7c78c0773-THCDED&bsft_link_id=9&bsft_mime_type=html&bsft_ek=2020-12-23T22%3A31%3A07Z&bsft_lx=5&bsft_tv=
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Us Too Warriors,

Prostate cancer regulator plays role in COVID-19, providing a promising treatment lead

The website below explains research showing How PCa treatment can block Covid -19 infection which I discussed in past emails !!

Best Holiday
Peter

By taking a lesson from prostate cancer, researchers now have a promising lead on a treatment for COVID-19. Two proteins, ACE2 and TMPRSS2, help the coronavirus gain entry and replicate within cells. TMPRSS2 is well-known to Arul Chinnaiyan, M.D., Ph.D. His lab discovered that TMPRSS2 fuses with the ETS gene to drive more than half of all prostate cancers. They also knew that TMPRSS2 was regulated by the androgen receptor.

More Info - Click on the Link Below:

Link: "COVID-19"
or Go To
https://medicalxpress.com/news/2020-12-prostate-cancer-role-covid-treatment.html
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Us Too Warriors,

New Scan Finds Prostate Cancer Cells Hiding in the Body

After doctors found cancer in Dr. Mark Samberg’s prostate last spring, the 70-year-old retired urologist prepared to have his prostate removed. He knew that the surgery would cure him, assuming the cancer was confined to the organ.

But his doctors had a nagging concern — the cancer cells seen on the biopsy were aggressive and may already have escaped from his prostate. If so, the operation would not cure him. The problem for Dr. Samberg, and for many men with aggressive prostate cancer, was this: If there are cancer cells outside the prostate, how can they be found?

Now the Food and Drug Administration has approved a test that can locate prostate cancer cells wherever they are. Exuberant cancer specialists said the test would alter treatment for patients nationwide.

Best Holiday
Peter

More Info - Click on the Link Below:

Link: "Hiding"
or Go To
https://www.nytimes.com/2020/12/16/health/prostate-cancer-scan.html?referringSource=articleShare
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Us Too Warriors,

Food and Supplement study in FDA journal on natural treatments to Prevent Metastasis in many Cancers & PCa

My PSA as of October was though very low (0.048). But, it was doubling every 5 Months and at that rate it does not take long to get high. So I added 4 more natural PCa inhibitors and on Dec 16th the doubling time had increased to 12 months by my blood test - My Christmas present came early for Christmas. Look at the natural agents in the attached paper and see if you can give yourself a Present and as you know I am always looking for presents.

Best Holiday
Peter

More Info - Click on the Link Below:

Link: "Food and Supplement Study"
or Go To
http://rvaprostatecancersupport.org/PDF/12 21 20 1-s2.0-S102194981830084X-main.pdf

Us Too Warriors,

Prostate Cancer Patient Conference 2020

Check out the 21 different (Including Genetic testing) videos below that will fit your PCa condition.

2 Examples:
Discoveries Arise From Listening to Patients
Radiation Therapy, PSMA, Imaging (and exercise) - An easy to understand guide

Best
Peter

More Info - Click on the Link Below:

Link: "Conference 2020"
or Go To
https://malecare.org/conference/?utm_source=sendfox&utm_medium=email&utm_campaign=will-genetic-testing-help-me-live-longer-with-prostate-cancer-prostate-cancer-conference-presentations

Us Too Warriors,

Radiation Therapy Failure and Radiosensitization of Prostate Cancer

The paper attached below suggests Drugs and Supplements that may prevent radiation failure produced by the biomarkers.

Best
Peter

Review Article
Factors Implicated in Radiation Therapy Failure and Radiosensitization of Prostate Cancer

Helmut Bonkhoff

Copyright © 2012 Helmut Bonkhoff. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Tissue markers may be helpful in enhancing prediction of radiation therapy (RT) failure of prostate cancer (PCa). Among the various biomarkers tested in Phase III randomized trials conducted by the Radiation Therapy Oncology Group, p16, Ki-67, MDM2, COX-2, and PKA yielded the most robust data in predicting RT failure. Other pathways involved in RT failure are also implicated in the development of castration-resistant PCa, including the hypersensitive androgen receptor, EGFR, VEGF-R, and PI3K/Akt. Most of them are detectable in PCa tissue even at the time of initial diagnosis. Emerging evidence suggests that RT failure of PCa results from a multifactorial and heterogeneous disease process. A number of tissue markers are available to identify patients at high risk to fail RT. Some of these markers have the promise to be targeted by drugs currently available to enhance the efficacy of RT and delay disease progression.

More Info - Click on the Link Below:

Link: "Therapy Failure"
or Go To
http://rvaprostatecancersupport.org/PDF/12 16 20 593241.pdf

Us Too Warriors,

Targeting transcriptional regulation of SARS-CoV-2entry factors ACE2 and TMPRSS2Y

See paper attached below to fight Covid and PCa.

Best
Peter

Contributed by Arul M. Chinnaiyan, November 18, 2020 (sent for review October 16, 2020; reviewed by William L. Dahut and Nicholas Nickols)

Helmut Bonkhoff

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, employs two key host proteins to gain entry and replicate within cells, angiotensin-converting enzyme 2 (ACE2) and the cell surface transmembrane protease serine 2 (TMPRSS2). TMPRSS2 was first characterized as an androgenregulated gene in the prostate. Supporting a role for sex hormones, males relative to females are disproportionately affected by COVID19 in terms of mortality and morbidity. Several studies, including one employing a large epidemiological cohort, suggested that blocking androgen signaling is protective against COVID-19. Here, we demonstrate that androgens regulate the expression of ACE2, TMPRSS2, and androgen receptor (AR) in subsets of lung epithelial cells. AR levels are markedly elevated in males relative to females greater than 70 y of age. In males greater than 70 y old, smoking was associated with elevated levels of AR and ACE2 in lung epithelial cells. Transcriptional repression of the AR enhanceosome with AR or bromodomain and extraterminal domain (BET) antagonists inhibited SARS-CoV-2 infection in vitro. Taken together, these studies support further investigation of transcriptional inhibition of

More Info - Click on the Link Below:

Link: "SARS-CoV-2"
or Go To
http://rvaprostatecancersupport.org/PDF/12 16 20 2021450118.full-1.pdf
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Us Too Warriors,

FDA Puts RV001 on Fast Track for Treating Prostate Cancer

FDA fast tracks a vaccine treatment to block Metastasis. See below and attachment of Paper reporting results of clinic trial.

The U.S. Food and Drug Administration (FDA) has granted fast track status to RV001, RhoVac's investigational therapy for prostate cancer, the company announced. Fast track designation helps speed the approval of potential medicines that address unmet medical needs in serious or life-threatening conditions. It grants RhoVac greater access to FDA input throughout the regulatory process and makes RV001 eligible for accelerated approval and priority review, if it meets certain criteria. With the fast track designation, RhoVac also may apply for a "rolling review," in which the company submits sections of its biologic license application for review as they are completed, rather than all together after clinical testing finishes. "We are extremely pleased and proud that our drug candidate, RV001, has earned fast track designation by the FDA," Anders Månsson, RhoVac's CEO, said in a press release. "The fact that the FDA has reviewed our data, and found our drug candidate worthy of this level of priority ... sends a clear signal of recognition of the drug's potential to all our would-be partners, which is something of great importance to us," Månsson said. RV001 is a peptide-based medicine meant to prevent cancer recurrence and spread. The treatment mimics the Ras homolog gene family member C (RhoC), a protein that helps cancer cells migrate and take hold in other tissues, and stimulates the immune system to recognize and target cells producing this protein. While these treatments historically have shown poor effectiveness against solid tumors, the goal of RV001 is to target the metastatic cancer cells, rather than the solid primary tumor. In this manner, the treatment is expected to eliminate spreading cells before they establish hard-to-treat tumors outside the prostate.
Best
Peter

More Info - Click on the Links Below:

Link: "RV001"
or Go To
https://prostatecancernewstoday.com/2020/12/08/fda-puts-rv001-on-fast-track-for-treating-prostate-cancer/
*
Link: "Trial Info"
or Go To
https://www.clinicaltrials.gov/ct2/show/record/NCT04114825?term=RV001&cond=Prostate+cancer&cntry=US&draw=2&rank=1

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Us Too Warriors,

Melatonin

Cleveland Clinic Identifies Melatonin as COVID-19 Treatment

By Joseph Mercola
December 3, 2020 Updated: December 6, 2020
Print

Melatonin is a hormone synthesized in your pineal gland and many other organs. While it is most well-known as a natural sleep regulator, it also has many other important functions.
Melatonin Is a potent antioxidant with the rare ability to enter your mitochondria, where it helps “prevent mitochondrial impairment, energy failure, and apoptosis of mitochondria damaged by oxidation,” notes a 2007 review published in Frontiers in Bioscience. It also helps recharge glutathione, and glutathione deficiency has been linked to COVID-19 severity

Research has also found that melatonin is important in several other ways:
It plays an important role in cancer prevention
Is important for brain, cardiovascular, and gastrointestinal health
Boosts immune function in a variety of ways
May improve the treatment of certain bacterial diseases, including tuberculosis
Helps quell inflammation
May prevent or improve autoimmune diseases, including Type 1 diabetes
Is an important energy hormone that can influence your energy level
Helps regulate gene expression via a series of enzymes
Has anticonvulsant and antiexcitotoxic properties
Best
Peter

More Info - Click on the Link Below:

Link: "Melatonin"
or Go To
https://www.theepochtimes.com/cleveland-clinic-identifies-melatonin-as-covid-19-treatment_3592407.html

Us Too Warriors,

Natural-Aromatase-Inhibitors

I have been trying to block my Alpha estrogen receptor as with my use of Casodex I produce high testosterone which Aromatases in my blood from diet etc can turn the testosterone into estrogen which if it bonds to my Alpha estrogen receptor can grow the cancer. So I take Aromatase inhibitors to block estrogen formation. My list of twelve Aromatases is listed below the abstract that follows.

Xu Z, Wang Y, Xiao ZG, et al. Nuclear receptor ERRα and transcription factor ERG form a reciprocal loop in the regulation of TMPRSS2:ERG fusion gene in prostate cancer. Oncogene. 2018; 37(48):6259-6274 [PubMed] Article available free on PMC after 31/12/2019 Related Publications

The TMPRSS2:ERG (T:E) fusion gene is generally believed to be mainly regulated by the activated androgen receptor (AR) signaling in androgen-dependent prostate cancer. However, its persistent expression in castration-resistant and neuroendocrine prostate cancers implies that other transcription factors might also regulate its expression. Here, we showed that up-regulation of nuclear receptor estrogen-related receptor alpha (ERRα) was closely associated with the oncogenic transcription factor ERG expression in prostate cancer, and their increased coexpression patterns were closely associated with high Gleason scores and metastasis in patients. Both ERRα and ERG exhibited a positive expression correlation in a castration-resistant prostate cancer (CRPC) xenograft model VCaP-CRPC. We showed that ERRα could directly transactivate T:E fusion gene in both AR-positive and -negative prostate cancer cells via both ERR-binding element- and AR-binding element-dependent manners. Ectopic T:E expression under ERRα regulation could promote both in vitro invasion and in vivo metastasis capacities of AR-negative prostatic cells. Intriguingly, ERG expressed by the T:E fusion could also transactivate the ERRα (ESRRA) gene. Hereby, ERRα and ERG can synergistically regulate each other and form a reciprocal regulatory loop to promote the advanced growth of prostate cancer. Inhibition of ERRα activity by ERRα inverse agonist could suppress T:E expression in prostate cancer cells, implicating that targeting ERRα could be a potential therapeutic strategy for treating the aggressive T:E-positive prostate cancer.

Check this website==> https://www.canceractive.com/article/natural-aromatase-inhibitors
Follow are some of the Aromatase inhibitors I know I am taking. I expect that some of the other supplements are also inhibitor too
1. Femara - prescription to reduce breast growth and hot flashes - 1 pill/day
2. Foti ( also called emodin) 3/day
3. Chrysin 3/d
4 Grape seed Extract 3/d
5 DIM 3/d
6. Apigenin 3/d
7 Indole 3- Carbinol =I3C 3/d
8. Quercetin 3/d
9. Luteolin 3/d
10. Myricetin 3/d
11. Green tea 9/d
12. Curcumin 12/d

Best
Peter

More Info - Click on the Link Below:

Link: "Natural-Aromatase-Inhibitors"
or Go To
https://www.canceractive.com/article/natural-aromatase-inhibitors

Us Too Warriors,

Development of a stress response therapy targeting aggressive prostate cancer

Oncogenic lesions up-regulate bioenergetically demanding cellular processes, such as protein synthesis, to drive cancer cell growth and continued proliferation. However, the hijacking of these key processes by oncogenic pathways imposes onerous cell stress that must be mitigated by adaptive responses for cell survival. The mechanism by which these adaptive responses are established, their functional consequences for tumor development, and their implications for therapeutic interventions remain largely unknown. Using murine and humanized models of prostate cancer (PCa), we show that one of the three branches of the unfolded protein response is selectively activated in advanced PCa. This adaptive response activates the phosphorylation of the eukaryotic initiation factor 2– (P-eIF2) to reset global protein synthesis to a level that fosters aggressive tumor development and is a marker of poor patient survival upon the acquisition of multiple oncogenic lesions. Using patient-derived xenograft models and an inhibitor of P-eIF2 activity, ISRIB, our data show that targeting this adaptive brake for protein synthesis selectively triggers cytotoxicity against aggressive metastatic PCa, a disease for which presently there is no cure.

Also, Link 2

Drug Reverses Age-Related Mental Decline Within Days
Rapid Rejuvenation of Mental Faculties in Aged Mice Implicates Reversible Physiological ‘Blockage’ Behind Age-Related Cognitive Losses
Best
Peter

More Info - Click on the Link Below:

Link: "Stress Response Therapy"
or Go To
http://rvaprostatecancersupport.org/PDF/121 11 20 eaar2036.full.pdf

Drug Reverses Age-Related Mental Decline Within Days

Link: "Mental Faculties"
or Go To
https://www.ucsf.edu/news/2020/12/419201/drug-reverses-age-related-mental-decline-within-days

Us Too Warriors,

Metformin

I have been using Metformin to fight my cancer for about 5 years after Adovart stopped controlling the cancer growth. It reduces the sugar in the blood and is commonly used to help people with diabetes. It is important to have a glucose level in the higher 70's to be able to take Metformin. My glucose has been between about 86 to 93. If Glucose goes below 70 there is the chance that the person may pass out. But using metformin reduces inflammation which is a problem for cancer and covid. I mistakenly took double the maximum dose of Metformin when my doctor or pharmacy changed my pills from 500 mg to 1000mg pills without telling me. It caused me to throw up for several days until I read the label on the bottle.

Also, High dose Vitamin D3 reduces Covid deaths by 75% found in Spanish clinical analysis. High dose Vitamin D3 also helps men with advanced PCa survive too. A dose of 8,866 IU of vitamin D3 is what our group averaged when I had them quizzed. This is a good number to start with and then after 3 Months get a 25 OH vitamin D blood test to see if your blood level is between 60+ to 80 ng/ml. The variation of vitamin d absorption in the gut can be as much a factor of 7X that is why you need blood tests to know your number. I take about 17,000 IU of Vitamin D to get my level at 100ng/ml. In the winter, You should bump up Vitamin D in the winter when the Sun is low so the UV is absorbed before reaching the earth. Best
Peter

Diabetes Drug May Decrease COVID-19 Death Risk In Women

A recent study found an association between metformin and a significantly reduced mortality risk in women with type 2 diabetes or obesity who were hospitalized with COVID-19.

More Info - Click on the Link Below:

Link: "Metformin"
or Go To
http://rvaprostatecancersupport.org/PDF/12 11 20 Metformin.pdf

Us Too Warriors,

Key Genes in Prostate Cancer Progression:

This book chapter below may help you use and Understand your Gene analysis to help you control your cancer.

For example, with my TMPRSS2-ERG Mutation, my cancer is very responsive to lowering Dihydrotestosterone with Avodart/proscar and blocking the Androgen receptors with Casodex, and I read that inflammation with NF-Kb pathway pushes TMPRSS2-ERG mutated patients to have Mutations so their PTen gene (which is protective when working- not mutated) becomes mutated (inactive). This helps explain why I have been helped by Avodart, Proscar and recently by Casodex to block testosterone and I think my years of taking multiple anti-inflammatories over the years has keeped me from developing a mutation in my Pten gene which is a Killer,

Best
Peter

Key Genes in Prostate Cancer Progression: Role of MDM2, PTEN, and TMPRSS2-ERG Fusions

Abstract:

In recent years, multiple genes or their protein products have been linked to initiation and progression of prostate cancer. Such genes include TMPRSS2, ERG, PTEN, and MDM2. This chapter discusses the pathological roles as well as the potential diagnos‐ tic and therapeutic applications of these genes that are highly expressed in prostate cancer when compared to other cancer types. The presence of these genes and related defects are linked to growth, progression, metastasis, invasiveness and resistance in prostate cancers. While knowledge related to TMPRSS2, ERG, and PTEN have been accumulating in the last two decades, the prometastatic role of MDM2 has been emerging in the last few years and revealing important functions related to prostate cancer progression.

More Info - Click on the Link Below:

Link: "Key"
or Go To
http://rvaprostatecancersupport.org/PDF/12 7 20 51830 (1).pdf

Us Too Warriors,

"The COC Protocol in Prostate Cancer"

The protocol uses 4 drugs. Three of these off label drugs I had adopted over the years to fight PCa which are Metformin, Doxycycline and Statin. The Statin I use is different than the one they prescribe (but most will help fight PCa) and I have not yet adopted the worm medication (but I have them on hand and I am working on how to make them more absorbable by laboratory processing if my present trials do not slow my cancer per my PSA test in the next week.

Basically, the way their system works is they charge you $800 to see if your PCa conditions qualify you and once you do; they charge you $60 per month for the drugs which are not expensive for these drugs but they will not be covered by insurance.
Best
Peter

For More Info - Click on the Link Below:

Link: "COC"
or Go To
https://careoncology.com/the-coc-protocol-in-prostate-cancer/ref/2/

Us Too Warriors,

"“Fluciclovine (18F) PET/CT Impact on Clinical Management of Recurrent Prostate Cancer”

I hope all are well and celebrate a health Thanksgiving. The video attached below is by Dr. Androile who recommended Finasteride (1996) and the Avodart later to stop Dihydrotestosterone fuel PCa growth after BCR - this along with my supplements gave me 15 years of slow PSA growth after I experienced BCR in Year 2000. It is the Axumin test for BCR which he discusses in the video that helped find my Mets which so far Casodex has lowered my PSA which is considered undetectable by standard PSA test.

I think this Video will help you decide at what PSA values after BCR to get an Axumin test. It is more successful as the PSA rises. My PSa was 12.2 ng/ml when I could first get the test after FDA approval ( it is highly effective for detection at this PSA). It is a much better test lymph node mets than mpMRI imaging. MY MRI at that time detected no lymph node mets but Axumin found about 8 lymph node mets in addition to hip bone met. My MRI did not find the hip bone met initially but it did when a new MRI, after the Axumin, was extended to cover my Hips. I did not know the original MRI(s) 2 only looked at the pelvis ( If you do not look in the right place you will not find Mets). I hope this helps

Fluciclovine (18F) PET/CT Impact on Clinical Management of Recurrent Prostate Cancer
Gerald L. Andriole, MD, FACS, asserts that the fluciclovine PET-CT scan has a significant impact on the management of patients with biochemically recurrent prostate cancer. Best
Peter

Summary: Gerald L. Andriole, MD, FACS, asserts that the fluciclovine PET-CT scan has a significant impact on the management of patients with biochemically recurrent prostate cancer. Prostate cancer recurs in up to 40% of patients treated with surgery or radiation therapy for presumed localized disease. Unfortunately, conventional imaging is unlikely to identify the site of recurrence until the Prostate Specific Antigen (PSA) level exceeds 20 mg/mL. Choline PET scans are an improvement over conventional imaging but are not recommended until the PSA level exceeds 20 mg/mL.

Fluciclovine PET scans identify recurrence disease in about 40% of patients with PSA levels less than 0.8 mg/mL, but identifies higher portions of patients as PSA levels rise. In a treatment impact trial of more than 200 men with biochemically recurrent prostate cancer (the LOCATE study), treatment was changed in 59% of patients once the results of the fluciclovine PET scan were known. In 78% of these cases, the treatment changes were considered to be major.

To See the Video - Click on the Link Below:

Link: "Fluciclovine"
or Go To
https://grandroundsinurology.com/fluciclovine-18f-pet-ct-impact-on-clinical-management-of-recurrent-prostate-cancer/

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Us Too Warriors,

"Association of Presalvage Radiotherapy" and Antiandrogen Therapy

Check these websites. Best
Peter

Association of Presalvage Radiotherapy PSA Levels After Prostatectomy With Outcomes of Long-term Antiandrogen Therapy in Men With Prostate Cancer.

Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer

More Info - Click on the Links Below:

Link: "Presalvage"
or Go To
https://pubmed.ncbi.nlm.nih.gov/32215583/

Link: "Antiandrogen"
or Go To
https://pubmed.ncbi.nlm.nih.gov/28146658/

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Us Too Warriors,

How to handle a Relapse after treatment for prostate cancer.

Check this out if you are facing BCR like I have for the last 21 years. Best
Peter

Four key questions

If your PSA rises after prostate cancer treatment, answering four key questions will help you and your doctor determine next steps:

What were your risk characteristics, such as Gleason score, PSA, and cancer stage, at the time of diagnosis? (See Table 1.)
What type of treatment did you have? That will help determine your next treatment options.
How long has it been since you underwent initial therapy for prostate cancer? This helps indicate how aggressive follow-up treatment needs to be.
How fast is your PSA rising, as determined from several evaluations?

More Info - Click on the Link Below:

Link: "Relapse"
or Go To
https://www.health.harvard.edu/blog/how-to-handle-a-relapse-after-treatment-for-prostate-cancer-2009031122

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Us Too Warriors,

Bicalutamide and Metformin

43% of the men (3) getting Bicalutamide and Metformin had Undetectable PSA like I do (PSA less than 0.1) at 32 weeks of use. Best
Peter More Info - Click on the Link Below:

Link: "Undetectable"
or Go To
https://ascopubs.org/doi/abs/10.1200/JCO.2020.38.6_suppl.85

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Us Too Warriors,

GP24

German Doctors look smarter to me than American Doctors on treating biochemical recurrence with casodex

Best
Peter

Let me give you some background on Bicalutamide therapy in Germany and why Dr. Weise may recommend that. The European guidelines recommend a late start of ADT in case of a recurrence. E.g. when bone mets start to cause pain.

The German guidelines say, do not treat a rising PSA value with ADT while CT and bone scan (not a PSMA PET/CT!) show no metastases. You may start if the PSA value reaches 10 ng/ml.

More Info - Click on the Link Below:

Link: "GP24"
or Go To
http://rvaprostatecancersupport.org/PDF/11 22 20 GP24.pdf

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Us Too Warriors,

Imaging Technology

Topic: jinxing Yu's Zoom Meeting "How modern imaging technology helps patients who are under active surveillance, status post prostatectomy or radiation treatment?"

Best
Peter

Abstract:

How does modern imaging technology help patients who are under active surveillance, post prostatectomy or post radiation?

Jinxing Yu, MD
Professor of Radiology & Surgery
Director of Oncologic and Prostate Imaging
Department of Radiology
Virginia Commonwealth University Health

More Info - Click on the Link Below To See the Power Point Presentation Notes:

Link: "Power Point"
or Go To
http://rvaprostatecancersupport.org/PDF/11 22 20 Prostate Talk for prostate cancer supporting group 2020 (1).pdf

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Us Too Warriors,

piperlongumine

I am adding this supplement to my long list. See Website & Paper attached below for info.

Best
Peter

Abstract:

BACKGROUND:
—Elevated NF-κB activity has been previously demonstrated in prostate cancercell lines as hormone-independent or metastatic characteristics develop. We look at the effects of piperlongumine (PL), a biologically active alkaloid/amide present in piper longum plant, on theNF-κB pathway in androgen-independent prostate cancer cells.

METHODS:
—NF-κB activity was evaluated using Luciferase reporter assays and Western blotanalysis of p50 and p65 nuclear translocation. IL-6, IL-8, and MMP-9 levels were assessed usingELISA. Cellular adhesion and invasiveness properties of prostate cancer cells treated with PLwere also assessed.

RESULTS:
—NF-κB DNA-binding activity was directly down-regulated with increasingconcentrations of PL, along with decreased nuclear translocation of p50 and p65 subunits.Expression of IL-6, IL-8, MMP-9, and ICAM-1 was attenuated, and a decrease of cell-to-matrixadhesion and invasiveness properties of prostate cancer cells were observed.

CONCLUSIONS:
—PL-mediated inhibition of NF-κB activity decreases aggressive growthcharacteristics of prostate cancer cells in vitro.

More Info - Click on the Links Below:

Link: "Piperlongumine"
or Go To
http://rvaprostatecancersupport.org/PDF/11 21 20 nihms580665 (1).pdf
*
Link: "Purchase"
or Go To
https://bixabotanical.com/products/piper-longum-1?utm_medium=cpc&utm_source=google&utm_campaign=Google%20Shopping&utm_campaign=gs-2020-03-12&utm_source=google&utm_medium=smart_campaign&gclid=EAIaIQobChMI6N2hyKuU7QIVFK7ICh0R8QiTEAQYAyABEgL5X_D_BwE

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Us Too Warriors,

mCRPC: Cabazitaxel tops enzalutamide and abiraterone in quality of life outcomes

Key clinical point: In previously treated patients with metastatic castration-resistant prostate cancer (mCRPC), cabazitaxel significantly improved pain response, prolonged time to pain progression and reduced the risk of symptomatic skeletal events vs abiraterone or enzalutamide.

Best
Peter

More Info - Click on the Link Below:

Link: "Pain"
or Go To
https://www.mdedge.com/fedprac/clinical-edge/summary/prostate-cancer/mcrpc-cabazitaxel-tops-enzalutamide-and-abiraterone?group_type=week

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Us Too Warriors,

RVA Us Too - Avodart & Proscar and Metformin all reduce Covid deaths by 50 %

I hope you are or can get your Drs. to prescribe these drugs above to fight your PCa. You can get the high dose Vitamin D3, Vitamin C, Zn, Brown SeaWeed (Swanson inc), lactoferrin ( Swanson Inc) Nitric oxide booster(Snap inc) and guaifenesin decongestant ( pharmacy) over the internet which all can reduce covid deaths and may reduce PCa.

Best
Peter

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Us Too Warriors,

RVA Us Too - Covid treatment/ prevention -Zn, Vitamin C & D3,Nitric Oxide etc

I am sure you are aware that having PCa puts us plus the age most of us Carry puts us in a higher mortality range if we catch Covid.

I calculate my chance of Mortality at 40%,and my brothers at 55%and 80%.

These are the % Numbers if we were not taking things to mitigate the infection.

These are the agents I and my brothers are using plus a new anti- depressiant agent studied at U of Va discussed below : High doses Zn, Vitamins C & D3, Nitric Oxide, Brown Seaweed, Lactoferrin, Guafenesin and see far below antidepressant fluvoxamine.

See below for information

Best
Peter

Click on the Link Below:

Link: "Covid"
or Go To
https://neurosciencenews.com/antidepressant-coronavirus-17272/

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Us Too Warriors,

Metformin

I have taken metformin (for sugar control your blood sugar levels should be 75 so that metformin does not cause brain consciousness problems; my sugar is usually from 87 to 93) for several years I had my GP to add a Statin = Pravastatin in June for higher LDL than I had recently. Read the blog that follows and see if it makes sense for you.

and

Here is another link on the benefits of combining metformin with a statin for improving overall survival in high-risk prostate cancer. It was especially strong for those who started them after prostate cancer had developed and were under treatment. Again, it is not a randomized prospective trial. But the benefit to risk ratio makes this a compelling to consider these well established and safe (for most patients) medications. Worth discussing with one's MO if not already on them.

Individual and joint effects of metformin and statins on mortality among patients with high‐risk prostate cancer See below for information

Best
Peter

Click on the Links Below:

Link: "Blog"
or Go To
http://rvaprostatecancersupport.org/PDF/11 12 20 Blog.pdf
*
Link: "High Risk"
or Go To
https://onlinelibrary.wiley.com/doi/10.1002/cam4.2862

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Us Too Warriors,

Fight Multiple Cancers

This is a possible path to fight multiple cancers including PCa which I am investigating. See Attachments.
See below for information

Best
Peter

Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways :

Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells

Click on the Links Below:

Link: "Benzimidazoles"
or Go To
http://rvaprostatecancersupport.org/PDF/11 12 20 Benzimidazoles.pdf
*
Link: "Fenbendazole"
or Go To
http://rvaprostatecancersupport.org/PDF/11 12 20 Fenbendazole.pdf

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Us Too Warriors,

Blog

Blog Link below. Discusses some of the Pathways I am trying to follow to fight my Cancer. It is suggested it may work for CRPC after Xrandi failure.

See below for information

Best
Peter

Click on the Link Below:

Link: "Blog"
or Go To
https://healthunlocked.com/advanced-prostate-cancer/search/posts?query=I%20vitro%20evidence%20for%20effectiveness%20of%20Simvastatin%20Metformin%20combination%20against%20Enzalutamide%20resistant%20CRPC&page=1

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Us Too Warriors,

Another Clinic Trial to consider.

Hold Lifted on Phase 1 Trial Testing P-PSMA-101 CAR T-cell Therapy in mCRPC

See below for information

Best
Peter

Click on the Link Below:

Link: "Clinic Trial"
or Go To
https://prostatecancernewstoday.com/

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Us Too Warriors,

Cellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications

This long Paper 132 paper analyzes out how mutation changes as PCa progresses. I think it may have answers if you can find them for your cancers. It will take a lot of digging to relate to your gene analysis.

See below for information

Best
Peter

Abstract: :
Prostate cancer is the most frequent nonskin cancer and second most common cause of cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with many patients exhibiting an aggressive disease with progression, metastasis, and other patients showing an indolent disease with low tendency to progression. Three stages of development of human prostate tumors have been identified: intraepithelial neoplasia, adenocarcinoma androgen-dependent, and adenocarcinoma androgen-independent or castration-resistant. Advances in molecular technologies have provided a very rapid progress in our understanding of the genomic events responsible for the initial development and progression of prostate cancer. These studies have shown that prostate cancer genome displays a relatively low mutation rate compared with other cancers and few chromosomal loss or gains. The ensemble of these molecular studies has led to suggest the existence of two main molecular groups of prostate cancers: one characterized by the presence of ERG rearrangements (~50% of prostate cancers harbor recurrent gene fusions involving ETS transcription factors, fusing the 50 untranslated region of the androgen-regulated gene TMPRSS2 to nearly the coding sequence of the ETS family transcription factor ERG) and features of chemoplexy (complex gene rearrangements developing from a coordinated and simultaneous molecular event), and a second one characterized by the absence of ERG rearrangements and by the frequent mutations in the E3 ubiquitin ligase adapter SPOP and/or deletion of CDH1, a chromatin remodeling factor, and interchromosomal rearrangements and SPOP mutations are early events during prostate cancer development. During disease progression, genomic and epigenomic abnormalities accrued and converged on prostate cancer pathways, leading to a highly heterogeneous transcriptomic landscape, characterized by a hyperactive androgen receptor signaling axis.

Click on the Link Below:

Link: "Mutation Changes"
or Go To
http://rvaprostatecancersupport.org/PDF/11 5 20 PCa-Jerry Pten P53 TMPRSS2-ERG Spink1 Cellular.pdf

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Us Too Warriors,

Cannabinoids

Another armamentarium I will add to my present treatment. See blog & paper below for your information. CBD oil has made my wife a new woman! by helping her with sleep which has mitigated her body pains.

See below for information

Best
Peter

BACKGROUND AND PURPOSE:
Cannabinoid receptor activation induces prostate carcinoma cell (PCC) apoptosis, but cannabinoids other than D9 -tetrahydrocannabinol (THC), which lack potency at cannabinoid receptors, have not been investigated. Some of these compounds antagonize transient receptor potential melastatin type-8 (TRPM8) channels, the expression of which is necessary for androgen receptor (AR)-dependent PCC survival.

Click on the Links Below:

Link: "Paper"
or Go To
http://rvaprostatecancersupport.org/PDF/11 5 20 De-petrocellis-2013-Non-thc-cannabinoids-inhibit-prosta.pdf

Link: "Blog"
or Go To
http://rvaprostatecancersupport.org/PDF/11 5 20 Blog follows.pdf

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Us Too Warriors,

Myricetin

Myricetin supplement is more effective than Quercetin in fighting PCa especial when ADT treatment fails and cancer grows without testosterone.
See below for information

Best
Peter

Abstract:

Myricetin is a common plant-derived flavonoid and is well recognised for its nutraceuticalsvalue. It is one of the key ingredients of various foods and beverages. The compound exhibits a widerange of activities that include strong anti-oxidant, anticancer, antidiabetic and anti-inflammatoryactivities. It displays several activities that are related to the central nervous system and numerousstudies have suggested that the compound may be beneficial to protect against diseases suchas Parkinson’s and Alzheimer’s. The use of myricetin as a preserving agent to extend the shelflife of foods containing oils and fats is attributed to the compound’s ability to protect lipidsagainst oxidation. A detailed search of existing literature revealed that there is currently nocomprehensive review available on this important molecule. Hence, the present work includesthe history, synthesis, pharmaceutical applications and toxicity studies of myricetin. This report alsohighlights structure-activity relationships and mechanisms of action for various biological activities.

To See the Paper and Website:

Click on the Links Below:

Link: "Paper"
or Go To
http://rvaprostatecancersupport.org/PDF/10 30 20 Semwal-2016-Myricetin-a-dietary-molecule-with-d.pdf

Link: "Website"
or Go To
https://www.betterhealthinternational.com/source-naturals-myricetin-100-mg-60-tablets?/?utm_campaign=google_call&gclid=CjwKCAjw8-78BRA0EiwAFUw8LDinw4HX_xaIfBt4NNMeStPVxcUJdUHpz2acxOrK6PenHjoMDzmwBxoCWrAQAvD_BwE

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Us Too Warriors,

Key Genes in Prostate Cancer Progression: Role of MDM2, PTEN, and TMPRSS2-ERG Fusions

This will help all understand why gene testing can help. See below.

Best
Peter

Abstract

In recent years, multiple genes or their protein products have been linked to initiation and progression of prostate cancer. Such genes include TMPRSS2, ERG, PTEN, and MDM2. This chapter discusses the pathological roles as well as the potential diagnos‐ tic and therapeutic applications of these genes that are highly expressed in prostate cancer when compared to other cancer types. The presence of these genes and related defects are linked to growth, progression, metastasis, invasiveness and resistance in prostate cancers. While knowledge related to TMPRSS2, ERG, and PTEN have been accumulating in the last two decades, the prometastatic role of MDM2 has been emerging in the last few years and revealing important functions related to prostate cancer progression.

To See the Study:

Click on the Link:

Link: "Study"
or Go To
http://rvaprostatecancersupport.org/PDF/10 29 20 10.5772_64337 (1).pdf

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Us Too Warriors,

Vitamin D

Frailty is an issue all of us may face as we age if we have success fighting PCa that is contributed to by ADT and Chemo drugs.

I have discussed the Need for Vitamin D, Vitamin K2, CoQ10, Magnesium, Nitric Oxide Booster and to keep muscle, bone and exercise to keep our body working. See website below but like most Medical papers on vitamin D3 level their high level is low (= 4000IU). The average of our group (50 men responding) in 2011 was = 8666IU. The only way to know if you are taking a good amount is a 25 OH Vitamin D3 blood test. It ideally would be at least 65 to 80ng/ml of blood. I keep my and my wife's level at 100 ng/ml in our blood. I take 15,000 IU and My wife takes 10,000 IU for us to have the same amount in our blood (100ng/ml). My gene analysis shows that I only absorb only 60%. I take this high dose in the hope this will allow me to play soccer with my Buddies when Covid is over and soccer goals like I did last fall. Website below:

Best
Peter

To See the Website below:

Click on the Link:
Link: "Vitamin D"
or Go To
https://www.medicalnewstoday.com/articles/very-high-dosages-of-vitamin-d-may-delay-frailty-in-old-age?utm_source=newsletter&utm_medium=email&utm_campaign=MNT%20Daily%2
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Us Too Warriors,

Natural Products ( Flavanoids $ Drugs) that inhibit Covid and PCa from binding energies by computer molecular modeling calculations

The attached Papers suggest natural products that may bind to TMPRSS2 protease proteins to fight Covid and PCa. I had projects in dentistry about bone mineralization using molecular modeling about 25 years ago so I know it is very complex. The simplified way to look at it is:"the more negative the sum of all the binding energies among the natural products and TMPRSS2; the stronger the bond so that it (the bound natural product molecules) will interfere with TMPRSS2, stopping the Covid virus from entering our cells or the growth of PCa. These natural molecules found in food or supplements (Neohesperidin, Myricitrin, Quercitrin, Naringin, Icariin, and Ambroxol) were found to work against the TMPRSS2 protein in the paper . You will have to search for these supplements as I will to find sources.

These following drugs also block TMPRSS2 proteins by binding to them; Camostat, Bromhexine and Guaifenesin. Camostat is used in Japan for pancreatitis. Bromhexane is available overseas in cough medicines as I discussed in another recent email. Guaifenesin is found in American over-the- counter Cough/Mucus relieving medicines (Easiest to get at a drugstore). Do not use any cold/cough medicine that contains DM==>Dextromethorphan which is bad for prostate ( cancer/ enlargement). These cough relief agents release TMPRSS2 from our throat and chest so they can be spit out to excrete them form body so the can do not harm.See below for the paper.
Best
Peter

To See the paper below:

Click on the 3 Links:
Link 1 "Covid"
or Go To
http://rvaprostatecancersupport.org/PDF/10 27 20 PCa-TMPRSS2 natural product inhibitors for PCa and Covid.pdf
*

Link 2 "Anti-TMPRSS2"
or Go To
http://rvaprostatecancersupport.org/PDF/10 27 20 tbsd_a_1798813_sm6268.pdf
*

Link 3 "Natural Poducts"
or Go To
https://www.tandfonline.com/doi/pdf/10.1080/07391102.2020.1798813?needAccess=true&
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Us Too Warriors,

The Androgen-Regulated Protease TMPRSS2

This is an over the counter used in tablets and Cough syrups available in many countries overseas - not in the USA. It rids the throat and lungs of TMPRSS2 proteins that initiate Covid damage there. It also suppresses PCa growth by blocking TMPRSS2-ERG growth promoting PCa Mutation formation by reducing TMPRSS2 proteins. This may be beneficial for covid and PCa but if you have liver or Lung issues you will need to be careful to limit the amount used and check these organs with blood tests to cause no harm.

The Androgen-Regulated Protease TMPRSS2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis
Best
Peter

To See the paper below:

Click on the Link:
"Therapeutic Implications"
or Go To
http://rvaprostatecancersupport.org/PDF/10 27 20 Lucas-2014.pdf
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Us Too Warriors,

Metastasis

The research website below suggest that men as they progress to Metastasis may develop this mutation and be less responsive to Chemo.

TMPRSS2-ERG in Blood and Docetaxel Resistance in Metastatic Castration-resistant Prostate Cancer

See website below for more information.

Best
Peter

To See the Website below:

Click on the Link:
"Metastasis"
or Go To
https://pubmed.ncbi.nlm.nih.gov/26948395/
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Us Too Warriors,

Casodex and Avodart to Control PSA

If you are on Casodex and Avodart to control your PSA after primary treatment - It may stop working after several years (at least then stopping the Casodex may work again for 20 to 50% of the men). We have one member who started to have a doubling time of one month after being on casodex that shocked his PSA to .04 but then it started to double in One month feeding on his Casodex. This suggests his cancer is really really feeding on the casodex. He stopped the Casodex and has been in remission for 14 years now!!!

See website below for more information - This is my next treatment if my PSA increases rapidly.

Best
Peter

To See the Website below:

Click on the Link:
"Control"
or Go To
https://csn.cancer.org/node/151359
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Us Too Warriors,

Veterans

If you are a veteran this may be helpful. The VA is setting up centers around the country to specialize in cancer treatments Check it out.

Best
Peter

To See the Website below:

Click on the Link:
"Veterans"
or Go To
https://www.research.va.gov/currents/1019-VA-National-Precision-Oncology-Program-brings-tailored-cancer-treatment-to-Veterans.cfm
*
Us Too Warriors,

Cellular and Molecular Mechanisms Underlying Prostate Cancer Development:Therapeutic Implications

Look at pages 46,47 and 49 for the SPINK1 mutation. (most important for African Americans)

Look at pages 20-23 on the relationship of TMPRSS2-ERG are related to P53 and P10 mutations. best Peter (Most important for Caucasin Americans)

Other pages may also be scanned to find other places for these mutations as well as looking at the references for more detail.
Best
Peter

To See the paper below:

Click on the Link:
"Therapeutic Implications"
or Go To
http://rvaprostatecancersupport.org/PDF/10 17 20 medicines-06-00082 (2).pdf
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Us Too Warriors,

A Must Read - Testosterone Metabolism and Prostate Cancer.

Following One line from the paper explains my successful treatment!!!!

"The existence of mAR and iAR suggest novel therapies. For example Casodex knocks out iAR but not mAR thus a combination of high T plus Casodex (or T plus Casodex plus Proscar(" + or Dutasteride PCMoon") might be effective." See [Friedman comment].

Friedman summarized this protocol in this [AMNI table].
Best
Peter

In this post we discuss theories of testosterone metabolism as it relates to prostate cancer. The research discussed here involves, in part, theories which, while based on scientific studies, still require additional investigation in order to establish their validity in a medical context. We will primarily rely on the four pathway model found in Endotext, an online endocrinology textbook, and further modelling efforts based on the highly accessed 2007 [PMID: 17678531] [Full text] and 2005 [PMID: 15777479] [Full Text] papers by Friedman in the journal: Theoretical Biology and Medical Modelling.

[Note that since this page was written Ed Friedman has published a book entitled "The New Testosterone Treatment: How You and Your Doctor Can Fight Breast Cancer, Prostate Cancer, and Alzheimer's". This book was just published so I have not seen it nor is the information below based on it. June 2013]

We start by discussing two naive single pathway models that likely correspond to what many believe to be the case but are too limited to give sufficiently complete understanding of the biochemical dynamics. To overcome this limitation, we then expand the single pathway model to a four pathway model. This is followed by a discussion of the androgen and estrogen receptors that form key components of the four pathway model. To this we discuss a further layer involving certain apoptotic and anti-apoptotic proteins. (Apoptotic proteins cause cancer cells to be killed, which is desirable, whereas anti-apoptotic proteins protect cancer cells which is undesirable.)

To See the paper below:

Click on the Link:
"Testosterone Metabolism and Prostate Cancer"
or Go To
https://palpable-prostate.blogspot.com/2008/02/testosterone-metabolism-and-prostate.html?fbclid=IwAR1BQto_SdyzRgjtGfxEaz0ZGTmcD6Gf8T4AyuwVqJZrp3jYdIWHoOyu4VY
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Us Too Warriors,

Garcinia Cambogia

The attached paper suggesting Garcinia Cambogia as a supplement to fight these PCa mutations is below
Gambogic Acid Induces Cell Apoptosis and Inhibits MAPK Pathway in PTEN-/-/p53-/- Prostate Cancer Cells In Vitro and Ex Vivo

Warning:
It appears that too much Garcinia Cambogia (more than160 mg /day) may lower kidney function and liver function. I do not have mutations in P10 or P53 so I am going to limit my Garcinia Cambogia pill intake to 80 mg/day. If you decide to use this supplement, I would suggest that you check your kidney and liver functions before you start these pills and after you have used them for six weeks check again to see they do no harm. If were you I would limit my intake to 80 mg of Garcinia Cambogia unless I had one of the bad mutations P10 or P53 negative and I would then up my intake to only 160 mg (2 of the Swanson pills/day) after I had used 1 pill and check it for 6 weeks to show it was no harm and then after 6 weeks on 2 pills I would check kidney and liver functions again. These pills are supposed to be for weight loss. Remember that excess fat and sugar and weight are bad for kidney and liver function as well as cancer.
Best
Peter

To See the paper below:

Click on the Link:
"Garcinia Cambogia"
or Go To
http://rvaprostatecancersupport.org/PDF/10 11 20 Pan2018_Article_GambogicAcidInducesCellApoptos.pdf
*
Can be Purchased at
"Purchase"
or Go To
https://www.amazon.com/Swanson-Garcinia-Cambogia-Milligrams-Capsules/dp/B00F5VV6B6/ref=sr_1_6?crid=1WL0O8WO2WLTM&dchild=1&keywords=garcinia+cambogia+swanson&qid=1602454659&sprefix=Garcinia+Cambogia+Swan%2Caps%2C138&sr=8-6
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Us Too Warriors,

Statin

I recently had my GP prescribe Pravastatin (40mg/d) which is a hydrophilic statin and I started to take Red rice yeast from Swanson Inc (SWU991) that contains a small amount of natural lipophilic statin at 3 pills/d. They lowered my LDL and raised my HDL and my kidney function significantly improved. TMG (From LEF) can increase kidney function also by lowering Homocysteine which I use from Swanson, Inc. See the Link attached below for more info.
Best
Peter

To See the paper below:

Click on the Link:
"Statin"
or Go To
http://rvaprostatecancersupport.org/PDF/10 11 20 Wang-2016-Statin-use-and-mortality-of-patient.pdf
*
Us Too Warriors,

FoTi

I have been taking Emodin = FoTi = Pterostilbene for about 14 years. I talked to Dr. Meyers about them in 2008 he warned me about taking them so I tripled down and took more. He had studied them and thought them a poison . I reasoned that they might poison my cancer. Here I am in remission still taking them for 14+ years later.
You decide for yourself.

Best
Peter

See paper attached below.
To see the Paper:
Click on the Link:
"FoTi"
or Go To
http://rvaprostatecancersupport.org/PDF/10 10 20 Lin-2012-Activation-of-ampk-by-pterostilbene.pdf
*
Us Too Warriors,

Nuclear Exclusion of the Androgen Receptor by Melatonin

My dose of 40 mg before bedtime is the level recommended to fight cancers and 3 mg per night is more like the value used to improve sleep.
Best
Peter

Abstract:
Androgen receptors (AR) play a crucial role in androgen-mediated processes and prostate cancer progression. The pineal hormone melatonin attenuates the androgen-dependent growth of benign and cancer prostate epithelial cells in vitro and may reverse clinical resistance to androgen ablation therapy in patients progressing on gonadotropin releasing hormone (GnRH) analogue. Where along the AR cascade does melatonin act remains to be determined. The effects of melatonin on AR localization, level and activity were assessed using androgen-insensitive prostate carcinoma PC3 cells stably transfected with a wild-type AR-expressing vector (PC3-AR).AR was localized to the PC3-AR cell nucleus in the absence of dihydrotestosterone (DHT). Melatonin caused a robust exclusion of the AR from the cell nucleus to the cytoplasm. The nuclear export inhibitor, leptomycin B prevented this process. The exclusion was selective since melatonin had no such effect on the nuclear localization of estrogen receptors alpha (ERalpha) in these cells. Melatonin also caused nuclear exclusion of the AR in the presence of DHT. In addition, it attenuated androgen induced reporter gene activity in PC3 cells co-transfected with the human AR and AR reporter plasmids. Elevated androgen concentrations counteracted melatonin's effects. Melatonin did not decrease AR level or androgen binding in the cells. The nuclear localization of the AR is a hallmark of its cellular activity. These data point to AR nuclear exclusion as a possible mechanism to attenuate androgen responses in target tissues.

To see the rest of the Paper:

Click on the Link:

"Melatonin"
or Go To
https://pubmed.ncbi.nlm.nih.gov/12127045/
*
Us Too Warriors,

Significant Association

After cross-checking the patients’ vitamin D levels with the severity of their COVID-19 symptoms and accounting for confounding factors, the researchers found that having a vitamin D level of above 30 ng/ml was significantly associated with having less severe COVID-19.

Among the 235 patients with confirmed COVID-19, only 32.8% had sufficient levels of the vitamin.

The researchers also found that the patients with sufficient vitamin D had higher blood lymphocyte counts and lower levels of C-reactive protein in their blood — both of which indicate a positive immune response.

The researchers speculate that this may have reduced the likelihood of developing cytokine storm, which can cause acute respiratory distress syndrome in COVID-19 patients, sometimes resulting in death.

The research, published in the journal PLOS ONE, could be valuable for doctors attempting to reduce the mortality rates of COVID-19 in the absence of an effective vaccine.

If further studies back up these findings, vitamin D supplements might offer a cost-effective way to limit the risk of severe COVID-19. It is important to note that this recent study has several limitations, which we address below.

To see the Paper:

Click on the Link:

"Significant Association"
or Go To
https://www.medicalnewstoday.com/articles/vitamin-d-sufficiency-may-reduce-complications-of-covid-19
*
Us Too Warriors,

The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells

I have taken Fucoidan supplements to lower my PSA in the past to treat my PCa before I went into remission. I did see a drop in my PSA on Fucoidan when it had been rising. Now I am taking Brown Seaweed from Swanson Inc at 3 pills per day and eating press sheets of Seaweed that I get for Asian and Indian stores to prevent Covid damage if I catch it. I hope it will also help keep my PCa in remission. The molecules copied below are present in Brown Sea Weed. See the paper below

To see the Paper:

Click on the Link:

"Seaweed"
or Go To
http://rvaprostatecancersupport.org/PDF/10 4 20 PCa-Seaweed's Fucoidan in PC-3 Prostate cells has-anticancer-effects in many pathways.pdf
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Us Too Warriors,

Phase II Study of Nitric Oxide .

See the paper below for the benefit of increasing Nitric Oxide in your Blood for PCa.

MY brother has had this benefit since I sent him some Nitric Oxide Booster(SNAP INC) COVID-19 to prevent blood Clots in his lungs if he caught CoVID. WHen his PSA dropped by 70% in two months I searched for the effect on PCa. The paper below shows the benefit.

To see the Study:

Click on the Link:

:
"Nitric Oxide"
or Go To
http://rvaprostatecancersupport.org/PDF/10 4 20 Siemens-2009-Phase-ii-study-of-nitric-oxide-dono.pdf
*
Us Too Warriors,

Websites which may help with Cancer Treatment costs below.

To Go to The Websites:

Click on the Link:

Link 1 - Does Medicare cover cancer treatment? :
"Medicare"
or Go To
https://www.medicalnewstoday.com/articles/does-medicare-cover-cancer-treatment

Click on the Link:

Link 2 - What is Medicare buy-in? :
"Medicare buy-in"
or Go To
https://www.medicalnewstoday.com/articles/medicare-buy-in?utm_source=newsletter&utm_medium=email&utm_campaign=MNT%20Daily%20News&utm_content=2020-10-01&utm_country=&utm_hcp=&apid=27042543&utm_term=A

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Us Too Warriors,

Discussion by email with Dr. Bilusic (NIH) about nitric Oxide for Prostate cancer

My email to Dr. Bilusic Follows:

Dr. Bilusic, If you are familiar with Nitric Oxides function in PCa I hope you will comment? I hope your research has made your path cross "How Nitric Oxide levels in the Blood affect prostate cancer growth". Mine path crossed it recently, when trying to protect my oldest brother from Covid-19. I sent him Nitric Oxide Booster (supplement used by muscle builders) because my online research suggested Nitric Oxide would prevent blood clots in the lung so oxygen levels and breathing would not be compromised. This was in June of this year at that time he had been off of ADT and Xtandi for 7 months (It was still working for at least 4 years before he stopped). When he stopped the fatigue and ability to walk were too hard to stand. After being off ADT and Xtandi for 7 months in June, his PSA went from 0.078 in Dec 2019 to 6.8 in June 2020 with a doubling time of less than 2 months. After being on Nitric Oxide Booster for one month his PSA dropped to 5.8 and now in another month it is 2.3. (And he is walking without a cane!)

My ( peter's) interpretation follows of NO action from my reading:
Nitric oxide is complicated- It has three forms of which I am not very familiar with as to how, why and under what circumstances they occur and which ones help or not. I have attached several papers but there are more. The most encouraging result was that in a phase two clinic among 29 men with recurrent PCa after radiation or surgery, 17 (62%) completed the 24 month trial with a heart Nitric Oxide medication. These 17 men had longer doubling times with average going from 13 months at start to 31 months at the end. I have not gotten the paper details yet. But I suspect that the men that did not stay on trial had PSA progression. There seems to be multiple Drugs/supplements/foods=beets & greens that can generate Nitric oxide and possibly many routes of action.
Cancers like We(Me & 2 Brothers) have with androgen sensitive growth seems to respond best to Nitric Oxide treatment. WE have a germline mutation =TMPRSS2-ERG fusion mutation. The mode of action that seems most to explain the beneficial results is: The indication is that Low Nitric Oxide promotes HIF-1 which is "Hypoxia inducing factor" which promotes angiogenesis = blood vessel growth to feed the cancer. But High levels of Nitric Oxide promote the Action of P53 which is the best anticancer molecule we have helping us. If a man has a P53 mutation so it does not function right then Nitric Oxide may not be helpful or as helpful ( But Stopping HIF-1 May still help to some extent?). Also, If a man's cancer is not responsive to androgen then Nitric Oxide treatment may not be as helpful.

Thanks for any comments, Best Peter

EMAIL REPLY from Dr. Bilusic follows:

Dr. Moon,

There is a lot of research going on about role of NO in prostate cancer. There are some contradictory studies. It is still considered experimental.

Best Marijo

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Us Too Warriors,

RVA Us Too - Low Testosterone and High DHT may be dangers in men for Covid damage/death but not ADT ???

Link 1.
I have read papers that show that reducing Dihydrotestosterone protects against Covid. Reducing DHT with Avodart increases testosterone. ADT also lowers DHT. Also see papers attached below

Link 2
COVID-19 May Deplete Testosterone For those who were asymptomatic, 65.2% reported a loss in libido.

I have attached Two Links below .

Best Peter
*
To Read The Papers:

Click on the Link:

Link 1 : "Therapeutic"
or Go To
https://www.healio.com/news/hematology-oncology/20200625/adt-and-covid19-a-therapeutic-discussion

Click on the Link:

Link 2 : "Testosterone"
or Go To
https://neurosciencenews.com/coronavirus-testosterone-17094/

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Us Too Warriors,

Nitric oxide and natural supplements effect on radiation damage

Link 1.
Radiation-induced gastrointestinal injury or radiation enteropathy is an imminent risk during radiation therapy of abdominal or pelvic tumors. Despite remarkable technological advancements in image-guided radiation delivery techniques, the risk of intestinal injury after radiotherapy for abdominal or pelvic cancers has not been completely eliminated. The irradiated intestine undergoes varying degrees of adverse structural and functional changes, which can result in transient or long-term complications. The risk of development of enteropathy depends on dose, fractionation, and quality of radiation. Moreover, the patients’ medical condition, age, inter-individual sensitivity to radiation and size of the treatment area are also risk factors of radiation enteropathy. Therefore, strategies are needed to prevent radiotherapy-induced undesirable alteration in the gastrointestinal tract. Many natural plant products, by virtue of their plethora of biological activities, alleviate the adverse effects of radiation-induced injury. The current review discusses potential roles and possible mechanisms of natural plant products in suppressing radiation enteropathy. Natural plant products have the potential to suppress intestinal radiation toxicity.

Link 2
Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction.

Link 3
Food Supplements to Mitigate Detrimental Effects of Pelvic Radiotherapy.

Link 4
Antibiotic Alleviates Radiation-Induced Intestinal Injury by Remodeling Microbiota, Reducing Inflammation, and Inhibiting Fibrosis

Link 5
Antibiotic Alleviates Radiation-Induced Intestinal Injury by Remodeling Microbiota, Reducing Inflammation, and Inhibiting Fibrosis

Link 6
Berberine Exerts a Protective Effect on Gut-Vascular Barrier via the Modulation of the Wnt/Beta-Catenin Signaling Pathway During Sepsis

Link 7
Total body irradiation-induced colon damage is prevented by nitrate-mediated suppression of oxidative stress and homeostasis of the gutmicrobiome. Nitric Oxide

I have attached Seven Links below .

Best Peter
*
To Read The Papers:

Click on the Link:

Link 1 : "Therapeutic Potential"
or Go To
https://www.tandfonline.com/doi/abs/10.1080/09553002.2018.1552374

Click on the Link:

Link 2 : "Baicalein"
or Go To
https://europepmc.org/article/med/31474856

Click on the Link:

Link 3 : "Food Supplements"
or Go To
https://www.siftdesk.org/index-article/Food-Supplements-to-Mitigate-Detrimental-Effects-of-Pelvic-Radiotherap/346639/58

Click on the Link:

Link 4 : "Antibiotic"
or Go To
https://pubmed.ncbi.nlm.nih.gov/32095719/

Click on the Link:

Link 5 : "Quercetin"
or Go To
http://rvaprostatecancersupport.org/PDF/9 29 20 Protective Effects of Quercetin on Intestinal Damage from radiation in rats.pdf

Click on the Link:

Link 6 : "Berberine"
or Go To
http://rvaprostatecancersupport.org/PDF/9 29 20 Berberine Exerts a Protective Effect on Gut mucosa from radiation.pdf

Click on the Link:

Link 7 : "Nitric Oxide"
or Go To
http://rvaprostatecancersupport.org/PDF/9 29 20 Nitric Oxide.pdf

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Us Too Warriors,

Androgen deprivation Therapy (ADT for PCa) and low testosterone may Increase chances of Kidney damage

My last brother diagnosed (Oct2019) with PCa has reduced Kidney Function and lower levels of testosterone so I thought I should see if there could be a connection between low testosterone and Kidney function.

The two papers attached below show there can be an increased problem with kidney function with low testosterone natural and by use of ADT. So if you have either of these conditions you need to check your Kidney function with CBC blood tests to see if it is affecting your kidneys by looking at your GFR levels and your Creatinine level.

Best Peter
*
To Read The Papers:

Click on the Links:

Link 1 : "Link 1"
or Go To
http://rvaprostatecancersupport.org/PDF/9 25 20 David-Testosterone Replacement Therapy (TRT) is Associated better Kidney function in Veterans.pdf *

To Read More Local Information:

Click on the Link:

Link 2 : "Link 2"
or Go To
http://rvaprostatecancersupport.org/PDF/9 25 20 joi130032.pdf
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Us Too Warriors,

News

Rex Waterbury, our Doctor member from VA Beach, passed away while trying to get into a Clinical trial in California recently. He was a real fighter who found he had the P10 somatic PCa Gene mutation. It was discovered from his gene analysis several years ago when he had gone to Germany to get LU177. This chemo treatment was to fight his cancer early last year and gave him another year. He will be missed.

Also Jerry Deans is fighting and trying to figure out bladder and bowel infections and dealing with pain and weakness from their effects. Please Keep him in your Prays.

My Brother Don, who stopped Xtandi and Lupron because the treatment was making his legs weak and walking difficult late last year even though it was working to keep his PSA Low (0.078) when he stopped. By June of this year his PSA had risen to 6.8 and was doubling every 2 months or less. I sent him Nitric OXide Booster by Snap Inc to fight COVId. He took it for a month and his PSA dropped to 5.8 and was not doubling any more. He has now taken it for another 6 weeks and his PSA is now 2.2 this week.

After the first result, I googled:
"Nitric Oxide to fight prostate cancer" and found research articles that show low Nitric Oxide in the blood grows prostate cancer and high Nitric Oxide in the blood fights prostate cancer. So I Now take 3 pills of the Nitric Oxide booster every day plus I am eating pickle beets several times a day as does my brother. I have 12 jars (2lbs each) on my kitchen floor that I am working on. All men over 40 will tend to have low Nitric oxide in the blood and by 80 years it will be down to 5% of a 20 year old. It is One reason older men die from Covid. My Saliva test for Nitric oxide has gone from a very light pale pink to bright rose color showing my nitric oxide level has gone up greatly in my blood. I think my muscle mass has improved and weight lifting has gone up 25 to 50% and my brother is no longer walking with a cane.

Hallelujah!

The website below shows online purchase at about $1per strip in a box of 10 strips. The simple Directions are included in the box. I test my nitric oxide before treatment and found it very low at a pale pink. And after about 3 nitric Oxide booster pills per day for 2 weeks it was a brite rose showing it has gone up and starting to approach a good level. I am eating beets a couple of times a day besides taking 3 NO pills .

Best Peter
*

To Order the Strips:

Click on the Link:

Link 2 : "Berkeley Life Nitric Oxide Test Strip"
or Go To
https://www.amazon.com/dp/B01M74FOXH?tag=sa-b2c-new-20&linkCode=osi&th=1&psc=1

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Us Too Warriors,

Foundation One

My contact David Smarsh at Foundation One gave me the list of Doctors below at Hunter-McGuire Hospital for genetic tests. This is a blood draw test for 374 somatic mutations occuring in Metastatic PCa. ( You must be metastatic to qualify for this test as most somatic mutations occur after mets form). At Hunter Holmes VA Medical Center you can have them reach out to:
Julie Whalen (NP), Nurse Practitioner, Oncology

804-675-5840 ----- Julie.whalen@va.gov

Alexander Neuwelt MD, Oncologist

804-675-5446 ----- Alexander.neuwelt@va.gov Best Peter
*
To See More Video Information:

Click on the Link:

Link 1 : "Foundation One"
or Go To
https://www.youtube.com/user/FoundationMedicine/featured *

To Read More Local Information:

Click on the Link:

Link 2 : "More Loc Info"
or Go To
http://rvaprostatecancersupport.org/PDF/09 22 20 More Loc Info.pdf
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Us Too Warriors,

Testosterone

The three papers below explain how my High T has put me in remission. See the 3 papers below and see if you configure it out?

Hints:

1. I have the TMPRSS2-ERG fusion mutation
2. I take an active form of Vitamin D on top of High dose Vitamin D3 supplement. The amount of active vitamin D must be controlled carefully because too much calcium in the blood is dangerous to the heart so I limit the amount I take and keep my dairy and cheese intake to a minimum (0).
3. I take Casodex which raises my testosterone to 1532 ng/ml.

Best Peter

To Read the 3 Papers Click on the Links:

Link 1 : "Paper 1"
or Go To
http://rvaprostatecancersupport.org/PDF/09 20 20 Wang-2014-Vitamin-d-intermediary-metabolism-a.pdf
*

Click on the Link 2:

Link : "Paper 2"
or Go To
http://rvaprostatecancersupport.org/PDF/09 20 20 Roberts-2017-Vitamin-d-receptor-activation-reduc (1).pdf
*

Click on the Link 3:

Link : "Paper 3"
or Go To
http://rvaprostatecancersupport.org/PDF/09 20 20 PCa-Tmprss-erg-fusions-confer-efficacy- Xtandi Semaan-2019-.pdf
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Us Too Warriors,

Vitamin D

I hope you have been taking high Vitamin D for PCa - which I think should be between 5,000 IU to 10,000 IU for most men. (and Women for Covid) The youTube video address website by Dr Campbell (a hero for his communication on CoVID)==> https://www.youtube.com/watch?v=V8Ks9fUh2k8 provides the result of clinical trial that show Vitamin D supplementation Video Proves Deaths and Hospitalization can be decreased greatly!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

Best Peter

To See the Video:

Click on the Link:

Link: "Vitamin D"
or Go To
https://www.youtube.com/watch?v=V8Ks9fUh2k8

and To Read More:

Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results

David O. Meltzer,MD, PhD; Thomas J. Best, PhD; Hui Zhang, PhD; Tamara Vokes, MD; Vineet Arora, MD, MPP; Julian Solway,MD

Click on the Link:

Link : "Test Results"
or Go To
http://rvaprostatecancersupport.org/PDF/9 20 20 Vit D.pdf
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Us Too Warriors,

Optimal chemohormonal sequencing for mCRPC MAY be Taxotere->Zytiga->Jevtana->Xtandi

(1) Taxotere (docetaxel) first

In a retrospective study presented at the Society for Urologic Oncology meeting, researchers at the Mayo Clinic reported on 112 patients with metastatic castration-resistant prostate cancer (mCRPC).

•Group A (80 men) had docetaxel (Taxotere) followed by one of the second-line hormonal therapies: either abiraterone (Zytiga) or enzalutamide (Xtandi)
•Group B (32 men) had a second-line hormonal therapy followed by Taxotere.
•Bone metastases were more common in Group B (87%) than Group A (58%)

Best Peter

To Read More:

Click on the Link:

Link: "Optimal Chemohormonal"
or Go To
https://www.prostatecancer.news/2019/12/optimal-chemohormonal-sequencing-for.html

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Us Too Warriors,

Erleada without ADT

Find below information on Casodex in place of ADT(Lupron) you may find useful.
Best Peter

You will have to create a login to vciew posts.

To Read More:

Click on the Link:

Link : "Casodex"
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/144329819/erleada-without-adt?uid=a13a9e99-aa40-4a58-bdb5-a2b5e68984b5&utm_campaign=advanced-prostate-cancer&utm_medium=email&utm_source=notification&utm_term=new-daily+digest#post-responses
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Us Too Warriors,

Testosterone to TREAT prostate cancer - are they crazy? No - it just may work. (mCRPC)

The attachment below shows that Bi Polar Testosterone can work to treat Hormone sensitive PCa not Just CRPC!!!
Best Peter

To Read More (Part 1 and Part 2):

Click on the Link:

Link : "Part 1"
or Go To
https://www.prostatecancer.news/2016/09/testosterone-to-treat-prostate-cancer.html

Link : "Part 2"
or Go To
https://www.prostatecancer.news/2016/09/testosterone-to-treat-prostate-cancer_5.html
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Us Too Warriors,

Vitamin C May help with Muscle mass development in older men and women

I take about 6 grams = 6000 mg per day to fight PCa and now the paper below indicates it can help with my muscle mass
Best Peter

Lower Dietary and Circulating Vitamin C in Middle- and Older-Aged Men and Women Are Associated with Lower Estimated Skeletal Muscle Mass

To Read More:

Click on the Link:

Link : "Muscle Mass"
or Go To
http://rvaprostatecancersupport.org/PDF/09 8 20 Muscle mass.pdf
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Us Too Warriors,

PCRI Virtual Conference

Check out the PCRI Virtual Conference next weekend and sign up for topics of interest in your cancer fight - A lot of areas are covered.
Best Peter

To sign up:

Click on the Link:

Link: "PCRI Virtual Conference"
or Go To
https://mailchi.mp/pcri/support-pcri-a-reminder-to-prostate-cancer-patients-everywhere-628276?e=dfb790b4b1

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Us Too Warriors,

High dose testosterone causes DNA damage and suppresses prostate cancer growth

I am very excited about this trial and my oldest Brother is in Seattle Wa. I do not know all the details yet, But I would like them to include Avodart to prevent high levels of Dihydrotestosterone which could drive Covid damage. OR use after we have a Vaccine for Covid.

Best Peter

To Read More:

Click on the Link:

Link: "Testosterone"
or Go To
https://cdmrp.army.mil/pcrp/research_highlights/20schweizer_highlight

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Us Too Warriors,

Androgen Receptor Blockers

PCa treatments which act as androgen receptor blockers like Xtandi reduces formation of TMPRSS2 proteins from provides access of Covid virus into lungs and testes cells that cause lung clots in cytokine storm and could make our younger sons not fertile if they get covid infected. AVodart and Proscar by blocking alpha reductase enzymes blocks Dihydrotestosterone and thus prevents formation of TMPRSS2. Attached below is a Clinical Trial study to see if Casodex Androgen Receptor Blocker in a clinical trial will fight COVID by blocking testosterone and lower TMPRSS2!!!!

If you do not have Lupron , or Xtandi or Avodart on board for your PCa treatment, I would recommend you get one of your doctors to prescribe Avodart as it is the easiest to get, low cost and minimum side effects to block TMPRSS2 to fight COVID. I have been taking it along with Proscar for 20 years as I have the TMPRSS2-erg Mutation.

The below Link is about A Randomized Clinical Trial Will Assess Efficacy and Safety of Bicalutamide in Hospitalized Patients With COVID-19

Best Peter

To Read More:

Click on the Link:

Link: "Bicalutamide"
or Go To
https://www.cancertherapyadvisor.com/home/cancer-topics/general-oncology/bicalutamide-covid19-coronavirus-randomized-clinical-trial-efficacy-treatment/

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Us Too Warriors,

Okra

When I was younger I did not like the texture of Okra, but I have acquired a taste for it and eat/enjoy it steamed. I have several plants in my garden (from seeds supplied from Rusty, one of our warriors - Thank You) and have been eating it a couple times a week recently.

The website below suggests it may fight several cancers, including PCa. (Okra May Fight Breast and Prostate Cancer)

Best Peter

To Read More:

Click on the Link:

Link: "Okra"
or Go To
http://www.edenprescription.com/Okra.html

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Us Too Warriors,

For Your Information

A list of Useful items to fight Cancer.

Best Peter

Link 1. Unique targeting of androgen-dependent and -independent AR signaling in prostate cancer to overcome androgen resistance

Link 2. Dose-finding and Pharmacokinetic Study of DpC, Administered Orally to Patients With Advanced Solid Tumors

Link 3. A new anti-cancer drug for prostate cancer overcomes the twin problems plaguing researchers for decades. It halts metastasis (tumour spread) and drug resistance.

To Read More:

Click on the Link:

Link 1. : "Unique"
or Go To
http://rvaprostatecancersupport.org/PDF/08 31 20 PCa-DpC.pdf
*
Link 2 : "Pharmacokinetic Study"
or Go To
http://rvaprostatecancersupport.org/PDF/08 31 20 Clinical Trial.pdf
*
Link 3 : "Halts Metastasis"
or Go To
https://www.miragenews.com/new-anti-cancer-drug-breakthrough-for-prostate-cancer/

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Us Too Warriors,

ADT

Read the Copied blog to understand why I have avoided ADT (lupron) for 26 + years and by going on Casodex about 2 1/2 years ago when my prior treatment (Avodart + proscar, Doxycycline, Metformin, Hi doseVitamin D3(10K IU) stopped working to slow PSA (when PSA >1.0 after BCR) after working for15 years and then it Accelerated for 3 years (then I added Casodex to my old treatments after Axium PET scan showed I had mets. Now my cancer is in remission, I think this worked because my cancer germline mutation (TMPRSS2-ERG Fusion) is very much Testosterone driven as Casodex is a testosterone receptor blocker of testosterone and Dihydrotestosterone (My cancer would likely have responded to Lupron too as Lupron will wipe out testosterone to low levels) and if you responded to Lupron you may well respond to Casodex. About 50% of men with PCa have germline mutation (TMPRSS2-ERG Fusion)

Your testosterone may come back when going off of Lupron and changing to Casodex if you have not been off Lupron much more than a year. It is also possible to get testosterone gels to bring testosterone back. My advantage for doing this has been to keep my bone density high, mental ability going,and muscles going with adequate exercise.

My motivation has been to allow me to keep playing soccer for the last 26 years after diagnosis. I was giving 6 pints of blood in the 6 weeks before my PCa surgery 26 years ago, water walking at the YMCA to help my recovery, and playing soccer every weekend, and double teaching my classes so students would not miss them while I was recovering.

I was only 54yrs the not my current 80 years, but I hope to go back to soccer after the summer heat breaks.

I am fortified against Covid with Zinc, Vitamin C, Vitamin D3, Nitric Oxide, Lactoferrin. Brown Seaweed and Avodart/proscar as is my family which will help fight the cytokine storm as do many of the antioxidants and anti-inflammatories I take. I hope this will help you understand where my drive to do self directed treatment comes from.

Read the blog below to understand the problems of ADT.

Best Peter

To Read the blog:

Click on the Link:

Link: "ADT"
or Go To
http://rvaprostatecancersupport.org/PDF/8 29 20 A question and a bit of a gripe.pdf

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Us Too Warriors,

Testosterone Replacement in the Treatment of Advanced Prostate Cancer

The video is from Prostapedia discussing work at John Hopkins and U. of Washington. I put website for the video below as I thought you might miss it when scanning Prostapedia.

Testosterone Replacement in the Treatment of Advanced Prostate Cancer - Sam Denmeade and Michael Schweizer

Sam Denmeade and Michael Schweizer join Charles Ryan at the 2019 Prostate Cancer Foundation Retreat (PCF 2019) to discuss testosterone replacement in advanced prostate cancer. The three discuss the impact of testosterone on prostate cancer cells, recent clinical trials involving testosterone replacement and the risks and benefits of adding this therapy to one’s treatment plan for prostate cancer patients.

Best Peter

To See the Video:

Click on the Link:

Link: "Testosterone Replacement"
or Go To
https://www.urotoday.com/video-lectures/prostate-cancer-foundation-2019/video/mediaitem/1594-testosterone-replacement-in-the-treatment-of-advanced-prostate-cancer-sam-denmeade-and-michael-schweizer.html?utm_source=newsletter_8185&utm_medium=email&utm_campaign=uroalerts-prostate-cancer-weekly&ct=t(EMAIL_CAMPAIGN_8_27_2020_9_15)&goal=0_bc8795358a-59b90751ff-149112481&mc_cid=59b90751ff&mc_eid=1bee78a54a

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Us Too Warriors,

Abstract 3481

Another reason to get off the couch see below.

Abstract 3481: Continuous load bearing exercise inhibits the development of prostate cancer bone metastasis

Best Peter

To Read More:

Click on the Link:

Link: "Abstract 3481"
or Go To
https://cancerres.aacrjournals.org/content/80/16_Supplement/3481

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Us Too Warriors,

Radiation and Immunotherapy

Dr Drake is one of Jerry Deans Docs in NY,NY.

This paper makes interesting points of How Radiation and Immunotherapy may work together to make a local radiation treatment have a systemic effect.

Best Peter

To Read More:

Click on the Link:

Link: "Radiation and Immunotherapy"
or Go To
https://grandroundsinurology.com/radiation-immunotherapy-the-abscopal-effect/

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Us Too Warriors,

Vitamin D3

I have long recommend /taken Hi dose Vitamin D3 for PCa but now the attached Youtube Video website explains Why it is important in preventing an over inflammatory reaction to the Virus that may damage the body and even kill. ( for your information, My C-Reactive protein is extremely low at 0.38 which correlates inversely with Vitamin D3 levels ( 100 ng/ml) which suggest I will be highly protected from the Virus inflammatory damage!!

Best Peter

To See the Video:

Click on the Link:

Link: "Vitamin D3"
or Go To
https://www.youtube.com/watch?v=mxxl5I0B7bg

*
Us Too Warriors,

For Your Information

A list of Useful items to fight Cancer. ( Herbs and Supplements )

Best Peter

To Read More:

Click on the Link:

Link: "FYI"
or Go To
http://rvaprostatecancersupport.org/PDF/08 18 20 FYI.pdf

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Us Too Warriors,

Brown Seaweed

When my PSA started rising fast from 3.0 to 4.8 ng/ml in 3 months in 2016 I started using Fucoxanthin Supplement pills (3/dinner) taken in combination with Edamame frozen soybean steam for dinner. In the next three months my PSA dropped to 3.6 ng/ml from the 4.8. I lost track of this process; so In the next year my PSA climbed to 12.2ng/ml (5 month doubling time) before I found in Dec, 2017 the treatment that has put my cancer in remission.

But, I have rediscovered Fucoxanthin as a treatment for Covid-19 and also for cancer. The papers attached support this Fucoxanthin as a treatment for cancer and Covid 19.

I just purchased 12 bottles of Brown Seaweed as my source of Fucoxanthin from Swanson INC to keep my cancer away and help if I am exposed to Covid 19. Read the papers so you can protect yourself and family. Stay healthy

Best Peter

To Read More:

Click on the Link:

Link: "Brown Seaweed"
or Go To
http://rvaprostatecancersupport.org/PDF/08 18 20 PCa-Brown Seaweed-Fucoxanthin.pdf

Link: "Covid-19"
or Go To
https://thehill.com/opinion/healthcare/510852-can-seaweed-really-help-us-fight-covid-19

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Us Too Warriors,

Melatonin

I have supplemented with Melatonin at a high dose of 40 mg before bed for years as a way to fight my cancer. The normal dose is 3 mg per night but I read an italian article many years ago where patients with a variety of very advanced cancers had reduction of their cancers when taking 40 to 50 mg/night.

As everyone is different if you try melatonin you need to perhaps increase gradually as for some they may feel too groggy on waking. I take 10 mg pills which can be bought as instant acting or a combination of time released and instant acting. I do not jump out of bed bright eyed and bushy tailed, but I usually do some leg stretches and bicycle movements on my back with my arms pulling on my knees to help move my legs. this gets my blood flowing to get out of Bed.

This helps keep me in shape for soccer which I hope to resume when the time is right. See the Attached article for all the cancer pathways melatonin may modify in fighting cancers.

Best Peter

To Read More:

Click on the Link:

Link: "Melatonin"
or Go To
http://rvaprostatecancersupport.org/PDF/08 17 20 Melatonin and Cancer.pdf

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Us Too Warriors,

Killing cancer cells

I have used Nsaids Over the counter at various times in my 26 year fight with cancer. I used Ibuprofen at higher doses for a year, and another time full dose aspirin. I stopped using them for many years because at these doses I think it was damaging my hearing but now I am taking one baby aspirin per day because I read it lowered ERG proteins which form part of my PCa Mutation =TMPRSS2-ERG fusion Gene. Killing cancer cells.

But, in addition, the following article suggests that baby aspirin improves PCa survival by fighting inflammation from the dying PCa cell debris and prevents it from feeding live cancer growth.

The dead cell debris is thought to contribute to the development of cancer treatment resistance as the dead cells help the cancer grow faster.

Best Peter

Dr. Sui Huang

Killing cancer cells is the fundamental objective of chemotherapy, radiation and targeted cancer therapies. However, these treatments often fail to eradicate tumors, and cancer often recurs.

So, is killing the problem?

Dr. Sui Huang (pictured above), professor and cancer biologist at Institute for Systems Biology, along with former mentee and longtime collaborator Dr. Dipak Panigrahy at Beth Isreal Deaconess Medical Center in Boston and colleagues at Harvard Medical School, show that dead cells, or cell debris, generated by treatments intended to eradicate tumor cells, actually act as strong stimulators of tumor progression. Their findings were published in The Journal of Experimental Medicine on November 30.

Traditional cancer therapies, then, become a double-edged sword: Too much and too fast, yet incomplete, killing of the tumor cell population will generate so much debris that the tumor stimulatory effect overpowers the decimation of tumor cells. The dead cells trigger a reaction that strengthens the cancer cells that have just escaped death by drugs: These become more like stem cells, which are resilient and robust, and eventually cause recurrence of the tumor.

To Read More:

Click on the Link:

Link: "Cancer Cells"
or Go To
http://rvaprostatecancersupport.org/PDF/08 14 20 Killing cancer cells.pdf

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Us Too Warriors,

Attachments

I hope you find something useful in the Attachments. The first attachment describes a phase 3 trial designed which will open in the 4 th quarter which is for advanced cancer that has failed Xtandi or Zytiga with rising PSA. The second attachment has many other topics that may be helpful. All the Best

Best Peter

To Read More:

Click on the Link:

Link: "4 th Quarter"
or Go To
https://www.onclive.com/view/fda-provides-regulatory-clarity-on-phase-3-trial-design-for-veru-111-in-mcrpc

*

Link: "Other Topics"
or Go To
https://www.prostatepedia.net/blogs/prostatepedia

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Us Too Warriors,

Two Diseases For The Price of One Drug

I have now found several drugs and supplements that both fight prostate cancer and Covid virus. I have always liked having the benefit to two diseases for the price of one drug or supplement. I think this works because the drug/supplements improve the immune system which aids both conditions see below. Lactoferrin and Nitric OXide which I have recently found fights the Covid Virus but on checking - I find it also fights prostate and maybe other cancers. I have recently found that high dose vitamin D3, Vitamin C and Zinc that I have used to fight Prostate cancer also fights the effects of Covid virus. But also anti prostate cancer drugs that lower Di-hydrotesterone like Avodart or proscar lower TMPRSS2 protein formation which is the bad acting protein that allows the virus to enter our organ cells to damage/kill them.

As you might expect, I take advantage of all these drugs and supplements to fight my cancer and to prevent the virus. In fact, My brother for the last month started taking Nitric Oxide Booster when his PSA was doubling every two months or less after coming off of Xtandi because of the debilitating side effects so that his PSA had risen from.08 to 6.8 in about 10 months. The last PSA this week(after 6 weeks since the last) his PSA had dropped to 5.8 after being on Nitric Oxide booster for a month and was no longer doubling. YAAaaa!!!! When you are older your Nitric oxide drops to 5% of that of a 20 year old. Beets are a good source of NO.

See what these supplements can do to fight Covid and Cancers. Look for papers attached far below.
Best Peter

To Read More:

Click on the Link:

Link: "Lactoferrin"
or Go To
http://rvaprostatecancersupport.org/PDF/08 03 20 PCa-Lactoferrin selectivel Kill PC-3 PCa cells.pdf

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Link: "Nitric Oxide"
or Go To
http://rvaprostatecancersupport.org/PDF/08 03 20 PCa-Nitric Oxide in Halting Cancer Progression.pdf

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Us Too Warriors,

Is there an association between statin use and the risk of prostate cancer mortality?

See the attached paper. I just recently had my GP prescribe the Statin =Prarsstatin because my Cholesterol was at 200 and my apolipoprotein was very high both signs are not good for heart function. This was unusual and may be because of covid as I have not been able to play soccer or go to the YMCA.

Anyway many of the things that cause heart problems also grow cancer. The use of this statin turns out to be the best choice for slowing PCa deaths; see attachment.
Best Peter

To Read More:

Click on the Link:

Link: "Statin Use"
or Go To
https://medivizor.com/view_article/46047983

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Us Too Warriors,

Heat Shock Protein 90

I am becoming more and more convinced that Heat Shock Protein 90 (HSP90) and mTOR inhibitors are the best weapons available to us (without Doctor help)in our fight PCa and other cancers. List below are my weapons in the fight with X after the ones I use daily(23 X's)!!!

HSP90 inhibitors also block the action of agent orange!

Also see the attachments below, I gave one my more important talks on HSP90 inhibitors in june of 2019 handout attached,
Best Peter

To Read More:

Click on the Link:

Link: "Heat Shock Protein 90"
or Go To
http://rvaprostatecancersupport.org/PDF/07 28 20 1-s2.0-S0223523420300301-main.pdf

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Link: "Hand Out"
or Go To
http://rvaprostatecancersupport.org/PDF/07 28 20 PCa-US Too Hand out on HSP90 PI3K-AKT-mTOR.pdf

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Link: "2 Heat Shock Protein 90"
or Go To
http://rvaprostatecancersupport.org/PDF/07 28 20 Hsp90_inhibitor.pdf

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Us Too Warriors,

A Randomized Clinical Trial Will Assess Efficacy and Safety of Bicalutamide in Hospitalized Patients With COVID-19

The website below describes the clinical trial to see if Casodex will reduce the symptoms of the Virus within three days of diagnosis by lowering TMPRSS2 proteins. I take casodex which has put my cancer in remission as I have the TMPRSS2-ERG fusion mutation.

See below

Best Peter

To Read More:

Click on the Link:

Link: "Clinic trial"
or Go To
https://www.cancertherapyadvisor.com/home/cancer-topics/general-oncology/bicalutamide-covid19-coronavirus-randomized-clinical-trial-efficacy-treatment/?utm_source=newsletter&utm_medium=email&utm_campaign=cta-update-hay-20200727&cpn=&hmSubId=dAxH82apgD81&hmEmail=fr7G03yN6cnk8ADvkszHEA2&NID=1578536835&email_hash=64cf9fac99d02b310899d9548da8fec7&dl=0&mpweb=1323-100174-809173

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Us Too Warriors,

Cryosurgical Tumor Cell Lysis and Intratumoral Immunotherapy

Regression of metastatic cancer and abscopal effects following in situ vaccination by cryosurgical tumor cell lysis and intratumoral immunotherapy: A case series

Abstract:

Purpose: To evaluate the efficacy and safety of a novel in situ cancer vaccination method for the treatment of aggressive solid tumors, with an initial focus on metastatic prostate cancer (PCa). Procedure: 27 consecutive patients with metastatic cancers (21 with PCa and 6 with other cancers), were treated by in situ cryosurgical lysis of tumor tissue followed by injection of ipilimumab, pembrolizumab or nivolumab, and sargramostim directly into the zone of lysis. This was followed by 30 daily s.c. injections of sargramostim. Patients received 1 to 3 cycles of the above therapy at intervals of ≥ 1 month. Responses to therapy were assessed by RECIST v.1.1 and for patients with PCa, serum PSA levels. This IRB-approved study, Shulman IRB Protocol #00027107, is a retrospective analysis (with prospective follow-up) of the practice of medicine of two physicians. All patients signed informed consent. Results: 21 patients with progressive metastatic PCa and 6 with other metastatic cancers (2 bladder, 1 pancreatic, 1 colon, 1 melanoma, and 1 unknown) were treated. RECIST responses for 2 patients (both with PCa) could not be evaluated due to a lack of follow-up imaging. Among the remaining 25 patients, CRs were seen in 9 (36%) patients and a PR in 1 (4%), for an ORR of 40%. SD was seen in 8 (32%) patients, and progression was seen in 7 (28%).
Best Peter

To Read More:

Click on the Link:

Link: "Immunotherapy "
or Go To
https://www.abstractsonline.com/pp8/#!/9045/presentation/7023

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Us Too Warriors,

Curcumin and Turmeric

Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine

Abstract:

The p53 tumor suppressor plays a major role in controlling the initiation and development of cancer by regulating cell cycle arrest, apoptosis, senescence, and DNA repair. The MDM2 oncogene is a major negative regulator of p53 that inhibits the activity of p53 and reduces its protein stability. MDM2, p53, and the p53-MDM2 pathway represent welldocumented targets for preventing and/or treating cancer. Natural products, especially those from medicinal and food plants, are a rich source for the discovery and development of novel therapeutic and preventive agents against human cancers. Many natural product-derived MDM2 inhibitors have shown potent efficacy against various human cancers. In contrast to synthetic small-molecule MDM2 inhibitors, the majority of which have been designed to inhibit MDM2- p53 binding and activate p53, many natural product inhibitors directly decrease MDM2 expression and/or MDM2 stability, exerting their anticancer activity in both p53-dependent and p53- independent manners. More recently, several natural products have been reported to target mutant p53 in cancer. Therefore, identification of natural products targeting MDM2, mutant p53, and the p53-MDM2 pathway can provide a promising strategy for the development of novel cancer chemopreventive and chemotherapeutic agents. In this review, we focus our discussion on the recent advances in the discovery and development of anticancer natural products that target the p53-MDM2 pathway, emphasizing several emerging issues, such as the efficacy, mechanism of action, and specificity of these natural products.
Best Peter

To Read More:

Click on the Link:

Link: "Curcumin and Turmeric"
or Go To
http://rvaprostatecancersupport.org/PDF/07 27 20 PCa-Natural products targeting the p53-MDM2 in PCa.pdf

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Us Too Warriors,

Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions

I would suggest you take many polyphenols pills to fight p53. I use many of them and they may be making my P53 more effective by increasing its positive P53 production to fight my cancer ? !!!!

Here is a list of the ones I take green tea, Dim, Quercetin, Fisetin, Berberine, Apigenin, curcumin, FoTi, Grape seed extract, pterostilbene, Wormwood, chaga mushroom, Turkey tail Mushroom, Boswella and more.
Best Peter

To Read More:

Click on the Link:

Link: "Targeting p53"
or Go To
https://www.sciencedirect.com/science/article/pii/S0734975019300667

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Us Too Warriors,

Dr. Bilusic (he spoke at one of our meetings) of NIH - Casodex and Metformin Clinic trial

This is the main treatment that put my cancer in remission. I also take doxycycline and avodart/+proscar along with many antioxidants and anti- inflammatories. This treatment works particularly well for men who have the TMPRSS2-ERG fusion mutation which may occur 50% or more PCa men.

My brothers have the same germline mutation I do. Chris Maxwell in our group took part in the NIH clinical study and had a lowering of his PSA but the study as a whole was not as successful as the selection was restricted and recruiting was difficult. I have been able to make indirect contact with Dr. Kinloch Nelson of Va Urology for Chris to continue the treatment which I hope he will. I think if they had tried it on men with TMPRSS2-erg fusion mutation it would have been very successful. I have also read a paper showing Xtandi is very successful in slowing cancer with mutation growth. Xtandi worked very well for my oldest brother for four years until the fatigue became too much so his PSA is going up now. I am trying to get him to try Casodex Etc which I think will have fewer side effects. The TMPRSS2-ERG mutation is very active in regard to testosterone so at low PSA it reacts well to Avodart and Proscar that keep my cancer growing slowly for 15 years until my PSA grew above 1.0 so by the time it got to 12.2 at 3 years later I had a bone met in my hip and 6+ in my lymph nodes.

Know 2.5 years later my PSA=0.028 and at this level i can not image mets so I am in remission as far as I can tell and my general practitioner is helping me to maintain this treatment as my VCU oncologist retired and and his replacement can not think outside the box of Standard of care Treatment.

If after reading the attachment if you have BCR cancer recurrence and you would like to consider this treatment, especially if you know you have TMPRSS2-ERG Mutation, email me and I will try to contact Dr Nelson in your Behalf to see if it can help you. You do not have to have cancer that fits the parameters of the NIH clinical trial.
Best Peter

To Read More:

Click on the Link:

Link: "Clinic trial"
or Go To
https://www.prostatepedia.net/blogs/prostatepedia/join-a-clinical-trial-casodex-bicalutamide-metformin

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Us Too Warriors,

TMPRSS2-ERG Fusion Mutation

It is not clear what TMPRSS2-ERG Fusion Mutation for men with PCa has on infection from the Virus infection (like me and 50% of the men with PCa) But it is suggested that drugs that lower Di-hydrotestosterone like Avodart and Proscar may reduce TMPRSS2 proteins. This protein makes the Virus that gets into organ cells to damage them. See below .
Best Peter

To Read More:

Click on the Link:

Link: "TMPRSS2-ERG"
or Go To
http://rvaprostatecancersupport.org/PDF/07 25 20 PCa- TMPRSS2 and Covid.pdf

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Us Too Warriors,

Prostate Cancer Research Institute - Videos

The Website below contains many videos with information for different issues with PCa. See what can help you

The Length of time for most of the videos are under 10 minutes and some go up to 2 hours.

Best Peter

To Read More:

Click on the Link:

Link: "Videos"
or Go To
https://www.wikihow.com/Lower-CRP-%28C%E2%80%90Reactive-Protein%29

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Us Too Warriors,

Reduce Your DHT

I have warned you in past emails to reduce your DHT with Avodart or/and proscar ( I use both) so that you reduce cancer stimulation but now also to prevent TMPRSS2 proteins created by DHT so they do not help the virus get into our cells and damage our organs. Lupron , casodex and xtandi etc will also reduce DHT ( but with more side effects of Avodart or proscar).

If you are Bald or Balding you have high DHT and must take action to bring it down if you are not using some of the lowering drugs listed above. DHT damages hair follicle cells causing hair to fall out to make us bald.

One of our men Sent the below.
Best Peter

To Read More:

Click on the Link:

Link: "Reduce Your DHT"
or Go To
http://rvaprostatecancersupport.org/PDF/07 21 20 One of our men.pdf

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Us Too Warriors,

C-reactive Protein

I have already sent you information on How to Lower C-reactive protein to fight the covid Virus using high doses of Vitamin D. The attachment below shows how to do the same for cancer and heart disease as well as covid using polyphenol supplements, diet and lifestyle changes to do even more C-reactive protein reduction.
Best Peter

To Read More:

Click on the Link:

Link: "C-reactive Protein"
or Go To
https://www.wikihow.com/Lower-CRP-%28C%E2%80%90Reactive-Protein%29

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Us Too Warriors,

Apigenin: A Promising Molecule for Cancer Prevention

Abstract Apigenin, a naturally occurring plant flavone, abundantly present in common fruits and vegetables is recognized as a bioactive flavonoid shown to possess anti-inflammatory, antioxidant and anticancer properties. Epidemiologic studies suggest that a diet rich in flavones is related to a decreased risk of certain cancers, particularly cancers of the breast, digestive tract, skin, prostate and certain hematological malignancies. It has been suggested that apigenin may be protective in other diseases that are affected by oxidative process such as cardiovascular and neurological disorders, although more research needs to be conducted in this regard. Human clinical trials examining the effect of supplementation of apigenin on disease prevention have not been conducted although there is considerable potential for apigenin to be developed as a cancer chemopreventive agent.
Best Peter

To Read More:

Click on the Link:

Link: "Apigenin"
or Go To
http://rvaprostatecancersupport.org/PDF/07 19 20 PCa-Apigenin- A Promising Molecule for Cancer Prevention.pdf

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Us Too Warriors,

How Avodart for PCa and Vitamin D3 at doses of 5,000 to 8,000 IU can fight Covid as well as PCa

The paper below is helpful to understand How Avodart for PCa and Vitamin D3 at doses of 5,000 to 8,000 IU can fight Covid as well as PCa by reducing the production of DHT and C-reactive Protein specifically that both reduce TMPRSS2 proteins in the lungs, Gut and other body organs causing the inflammation of the cytokine storm.

Best Peter

To Read More:

Click on the Link:

Link: "Avodart"
or Go To
http://rvaprostatecancersupport.org/PDF/07 19 20 A-closer-look-at-TMPRSS2-This-could-help-treat-COVID-19.pdf

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Us Too Warriors,

Vitamin D supplementation makes (lowers) my C-reactive protein very low = 0.57

My high Vitamin D supplementation makes (lowers) my C-reactive protein very low = 0.57; C - reactive Protein is considered low if =< 1.0.

My Vitamin D3 level is 100ng/ml which is considered the highest value that one should try to reach in your blood. The paper below shows the research backing up lowering of c-reactive protein to fight PCa. This Vitamin D3 supplementation lowers TMPRSS2 proteins which is related to my cancer mutation of TMPRSS2-ERG fusion which is one of the pieces of the puzzle that may have put my cancer in remission. About 50% of Prostate Cancer patients have this mutation

Best Peter

To Read More:

Click on the Link:

Link: "C-reactive Protein"
or Go To
http://rvaprostatecancersupport.org/PDF/07 19 20 PCa-C-reactive protein in prostate Growth AsianJAndrol163467-2256248_003736.pdf

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Us Too Warriors,

FDA Grants Priority Review to Relugolix for Men With Advanced Prostate Cancer

This will reduce the problems of heart and strokes problems from Lupron. See Below

An oral 120 mg dose of relugolix (Relumina) has received a priority review designation from the FDA for the treatment of patients with advanced prostate cancer, Myovant Sciences announced in a press release. The target FDA action date has been set for December 20, 2020.1

“We are delighted that the FDA has accepted for Priority Review our New Drug Application for relugolix, bringing us one step closer to providing a one pill, once a day potential new treatment option to men with advanced prostate cancer,” said Lynn Seely, MD, chief executive officer, Myovant Sciences. “As recently published in the New England Journal of Medicine, relugolix demonstrated superior efficacy and a 54% lower risk of major adverse cardiovascular events (MACE) compared to the current standard of care, leuprolide acetate injections, in the Phase 3 HERO study.”

Best Peter

To Read More:

Click on the Link:

Link: "Relugolix"
or Go To
https://www.targetedonc.com/view/fda-grants-priority-review-to-relugolix-for-men-with-advanced-prostate-cancer

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Us Too Warriors,

Bowel Problems

Some parameters which may affect PCa occurrence rate are discussed in the attachments. I am aware of a number of our men have bowel problems, Generally any inflammation is a problem for any one with cancer.

Association between inflammatory bowel disease and prostate cancer: A large‐scale, prospective, population‐based study

and

Hematologic Markers and Prostate Cancer Risk: A Prospective Analysis in UK Biobank.
Best Peter

To Read More:

Click on the Link:

Link: "Inflammatory Bowel Disease"
or Go To
https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.33048

and

To Read More:

Click on the Link:

Link: "Hematologic Markers"
or Go To
https://cebp.aacrjournals.org/content/early/2020/06/22/1055-9965.EPI-19-1525

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Us Too Warriors,

Vit D

RVa US too, family and Severn Men, I have been active in researching the benefit of Vitamin D levels in children in preventing rampant t cavities by increasing saliva flow, increasing calcium in saliva by better gut adsorption and producing antibacterial proteins in saliva.

On a personal basis, I have used it to fight my personal cancer for 26 years when my DNA analysis showed I am a poor Vitamin d absorber. And as Cancer Support group leader I have provider information to my group on its benefits for fighting cancers. website of our group "www.rvaprostatecancersupport.org". I have been successful in the last two years puting My PCa with bone mets in remission !!

Now, I am sending you a youtube website which describes how vitamin D interacts with macrophages to put Covid 19 on an anti-inflammatory path to stop the cytokine storm. I think Dr. Harvey Schienkein at my school would be best at explaining the many steps of the pathway of how it works but there are many references to follow to help understand. See website below, Best Peter

To See the Video:

Click on the Link:

Link: "Vit D"
or Go To
https://www.youtube.com/watch?v=mxxl5I0B7bg

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Us Too Warriors,

DNA Data

If you want to check your DNA for Germline Mutations which would make sense especially if you have PCa cancer in your family (3 brothers in my family with PCa). This is how I found my Germline Mutation by asking 23 & Me to download my DNA data to my computer then I uploaded it to My heritage web site which follows - the last I heard they charge only $10 for their analysis.

My Mutation (TMPRSS2-ERG gene fusion) is shared by one of my brothers and we are trying to get my remaining Brother Checked. I have found that this fusion gene responds well to aspirin to reduce the # of erg genes and therefore the # of fusion mutations. Also, It responds strongly to Testosterone so that is why Avodart was so successful for 15 years in slowing the cancer and now with Casodex added that blocks the androgen (testosterone) receptor I have gone into remission even with my very high testosterone ( 1500).

About 50% of men with PCa have this Mutation, which 50% do not so my treatment will not work for everybody and some men may have additional mutations in addition to mine. For example, The SPINK1 mutation does not produce ERG genes and is not receptive to ADT treatments like Casodex or lupron possibly ??

I am encouraging you to get your germline mutations checked and if you have advanced cancer you should get your Somna Mutation checked by biopsy or blood analysis thru your doctor, so you can try to find a drug treatment made to fight your specific mutation instead of the trial and error methods of trying one treatment after the other as your cancer progress as they fail.
Best Peter

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Us Too Warriors,

Dr. Meyers Prescription

I thought you might want to revisit Dr. Meyers prescription to see if it has anything to help you control your cancer. it is Attached below:

Best Peter

To Read More:

Click on the Link:

Link: "Dr. Meyers Prescription"
or Go To
https://grandroundsinurology.com/durable-complete-remission-prostate-cancer/

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Us Too Warriors,

PAP

I have had my eye on PAP testing over the years as it may help detect Bone Metastasis and high levels suggest that radiation for local PCa may not be affected as the cancer will likely have escaped the prostate. VCU lab no longer does the test so I get them through Life Extension(Lef.org) blood draw orders (that I prepare for) that I take to Lab Corp clinics for the draw. Now that my PSA is so low I am going to check my PAP as another way to check my bone mets to be sure they are not active. Life Extension Blood test sale ends July13 which you can use thru the next year. The paper attached will give you more information on PAP.

What I remember from the past reading that levels of PAP >1.5 to >3.0 or above are likely to suggest local radiation treatment would fail to control the cancer because it had escaped. See below I hope this helps

Best Peter

To Read More:

Click on the Link:

Link: "PAP"
or Go To
https://www.cancernetwork.com/view/reviving-acid-phosphatase-test-prostate-cancer

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Us Too Warriors,

Nitric Oxide

This image shows how we lose Nitric Oxide in our blood with time. At My age of 80 yrs, I am not even on the chart but with the Nitric Oxide booster supplement and Diet I got my No down to a 30 year old (I think) from My saliva test. You need to increase Nitric Oxide from diet into your blood to protect your heart, lungs, muscles and fight your cancer.

Best Peter

To See the Chart Only:

Click on the Link:

Link: "Chart"
or Go To
http://rvaprostatecancersupport.org/Pictures/NitricOxide.png

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Us Too Warriors,

Statin Pravastatin

I recently added a Statin pravastatin (pravastatin 40 mg oral tablet 1/d), Cholesterol total=202 and LDL=132 and Apolipoprotein B =117 and homocystiene =16.7. as My LDL was about isually about 100, my HDL was down to 56 instead of being 65. I am trying this statin for 3 months and examining my diet which suggests that shrimp, crabs and scallops will be reduced and exercise increased.

Best Peter

To take the Test on Statin and PCa:

Click on the Link:

Link: "Test"
or Go To
https://www.mdedge.com/fedprac/quiz/8839/prostate-cancer/prostate-cancer-risk-and-statin-use?channel=28799

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Us Too Warriors,

This is better for the heart than Lupron - if on ADT.

Oral Relugolix for Androgen-Deprivation Therapy in Advanced Prostate Cancer

Conclusions:
In this trial involving men with advanced prostate cancer, relugolix achieved rapid, sustained suppression of testosterone levels that was superior to that with leuprolide, with a 54% lower risk of major adverse cardiovascular events. (Funded by Myovant Sciences; HERO ClinicalTrials.gov number, NCT03085095.).
Best Peter

To Read More:

Click on the Link:

Link: "Relugolix"
or Go To
https://pubmed.ncbi.nlm.nih.gov/32469183/

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Us Too Warriors,

Androgen deprivation upregulates SPINK1 expression and
potentiates cellular plasticity in prostate cancer

Emergence of an aggressive androgen receptor (AR)-independent neuroendocrine prostate cancer (NEPC) after androgen-deprivation therapy (ADT) is well-known. Nevertheless, the majority of advanced-stage prostate cancer patients, including those with SPINK1-positive subtype, are treated with AR-antagonists. Here, we show AR and its corepressor, REST, function as transcriptional-repressors of SPINK1, and AR-antagonists alleviate this repression leading to SPINK1 upregulation. Increased SOX2 expression during NE-transdifferentiation transactivates SPINK1, a critical-player for maintenance of NE-phenotype. SPINK1 elicits epithelial-mesenchymal-transition, stemness and cellular-plasticity. Conversely, pharmacological Casein Kinase-1 inhibition stabilizes REST, which in cooperation with AR causes SPINK1 transcriptional-repression and impedes SPINK1-mediated oncogenesis. Elevated levels of SPINK1 and NEPC markers are observed in the tumors of AR-antagonists treated mice, and in a subset of NEPC patients, implicating a plausible role of SPINK1 in treatment-related NEPC. Collectively, our findings provide an explanation for the paradoxical clinical-outcomes after ADT, possibly due to SPINK1 upregulation, and offers a strategy for adjuvant therapies.
Best Peter

To Read More:

Click on the Link:

Link: "SPINK1"
or Go To
http://rvaprostatecancersupport.org/PDF/07 05 20 PCa-Androgen deprivation upregulates SPINK1expresion in PCa.pdf

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Us Too Warriors,

Sensing Oxidative Stress: The ROSp53 Pathway

At our meetings I have often expotisted the need to take antioxidant supplements to fight our cancers. The paper attached below discusses this in better detail in exploring how the P53 anticancer gene can protect us if it is functioning properly and not mutated. However if we know our mutation we may be able to find a treatment better suited to our mutation or find preliminary research which may add us in our fight of PCa.

For example with my TMPRSS2-ERG mutation may benefit from aspirin because Aspirin reduces ERG which may reduce the Fusion with TMPRSS2 and thus the amount of Mutations acting to grow the cancer. With the P10 Mutation, PARP inhibitors and ways to block Pi3k,AKt and mTOR pathways may fight the mutation. For the P53 mutation which Jerry is fighting we are trying to CBD oil which was recently found to fight lung cancer with this mutation.

For SPINK 1 Mutation search online for this paper by Mushtaq it looks promising but I have not had time to figure it out yet and could not down load to add to this email.

Mushtaq- "Comparative Expression Analysis Reveals Relationships between SPINK1, TUBB3, and EZH2, and Prostate Cancer Molecular Biomarkers in the Cancer Genome Atlas " It also some information related to P10 mutations.

I hope this encourage to try to get your gene Mutations examined so you can start looking for ways to use the information in the literature that you can search to find way to fight your cancer

Best Peter

To Read More:

Click on the Link:

Link: "ROSp53 Pathway"
or Go To
http://rvaprostatecancersupport.org/PDF/07 05 20 PCa-P53 Sensing-Oxidative-Stress-The-ROS-p53-Pathway.pdf

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Us Too Warriors,

Nitric Oxide

The Nitric oxide (NO) Molecule In Our Body Has Many Good Effects. I Am Going To State A Few Researched Effects But Unfortunately It Fall As We Age-It May Be Why Younger People Are Less Likely To Be Damaged Or Die From Covid.

Info for
1. NO is good for the heart
2. It helps Build Muscles and now there are muscle building supplements with NO.
3. You get more in your body by breathing in through the nose as it is released from nasal passages and by humming between breaths. and breathing out through the mouth- this is not easy to do without thinking about it
4. It helps oxygen blood saturation if small Amounts of NO are added to oxygen Breathed in for Covid therapy in the hospital
5. Dark Chocolate (w low sugar) and Beets are the source of NO.
6. You can Check your NO in your saliva by using a test strep from BERKELEYLIFE.COM -I WAS BETWEEN DEPLETED AND LOW WHEN I FIRST MEASURED MY NO SALIVA LEVEL THREE WEEKS AGO. NOW AFTER EATING PICKLED BEETS & LOW SUGAR DARK CHOCOLATE & TAKING A TAKING NITRIC OXIDE BOOSTER SUPPLEMENT I HAVE RAISED MY SALIVA NO TO BETWEEN THE "TARGETED TO HIGH LEVEL"

FROM SNAP ==>https://www.amazon.com/s?k=snap+nitric+oxide&hvadid=78409029

Info Prostate cancer
1. High levels of NO in blood are good for slowing this cancer growth and preventing CRPC.
2. See Paper attached FURTHER below THE EMPTY BLOCK BELOW:
BEST PETER Best Peter

To Read More:

Click on the Link:

Link: "Nitric Oxide"
or Go To
http://rvaprostatecancersupport.org/PDF/07 01 20 Yang And Ying Of NO in PCA.pdf

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Us Too Warriors,

This treatment maybe helpful for Immunotherapy which is being developed

Best Peter

To Read More:

Click on the Link:

Link: "Immunotherapy"
or Go To
http://rvaprostatecancersupport.org/PDF/06 30 20 PCa-Sipuleucel-T Completing the Mechanism of Actiond jaa021.pdf

Us Too Warriors,

The New Testosterone Treatment: How You and Your Doctor Can Fight Breast Cancer, Prostate Cancer, and Alzheimer's Paperback – June 11, 2013

The book below lays out a unique treatment (Start reading at page 207 -not standard of care) that is very close to many of the ideas and procedures I arrived at (over 26 years) to treat prostate cancer which seems to have put my PCa in remission after mets. I think you may find it helpful to adjust or slightly modify your standard of care to possibly make it more effective? I think you will find it worth the price.
Best Peter

Written by the leading authority on hormone receptors and prostate cancer, this book reveals the surprising truth about how you can prevent and treat breast cancer, prostate cancer, and Alzheimer's with testosterone and other FDA-approved drugs.For decades, doctors have sought to combat prostate cancer under the mistaken assumption that testosterone fueled its growth. But the latest research into the nature of hormone receptors and therapies using bioidentical instead of synthetic hormones have caused a shift in thinking and new hope for treating this cancer with testosterone. Today the medical profession equates a diagnosis of Alzheimer's with a death sentence. In fact, the only thing doctors do is throw ineffective drugs at it and resign themselves to failure. For the first time, this book explains how testosterone can halt the disease and cure early-stage Alzheimer's. Similar breakthroughs for fighting breast cancer follow close on the heels of these revelations, outlining how the avoidance of synthetic progestins and the use of aromatase inhibitors are crucial tools in prevention and treatment. At the core of this book is the remarkable observation that we experience our highest hormone levels during our teen years--a time of life when there is no breast cancer, prostate cancer, or Alzheimer's. Could bringing hormones back to teen levels be the key to vibrant good health? The answer is a resounding yes. This thoroughly researched guide to the latest biomedical research is must-reading for medical professionals and anyone concerned about their health.

To Order the Book - Click on the Link:

Link: New Testosterone Treatment
or Go To
https://smile.amazon.com/New-Testosterone-Treatment-Prostate-Alzheimers/dp/1616147237/ref=smi_www_rco2_go_smi_4368549507?_encoding=UTF8&dchild=1&ie=UTF8&keywords=book-The%20new%20testosterone%20treatment&qid=1593466191&sr=8-1
************
Us Too Warriors,

Consuming Gymnema Sylvestre Reduces the Desire for High-Sugar Sweet Foods

This supplement shuts down sugar receptors so that you do not produce the pleasant sensation of sweets so it easier not to over indulge which is harder when we are isolating at home. This will help you from growing your cancer and weight now . See below:

To Read More - Click on the Links:

Link: Gymnema Sylvestre1
or Go To
https://neurosciencenews.com/plant-sugar-craving-16593/

Link: Gymnema Sylvestre2
or Go To
https://www.mdpi.com/2072-6643/12/4/1046

Link: (Where to Find) Gymnema Sylvestre3
or Go To
https://www.bing.com/search?q=amazon.com%3A+gymnema+extract&form=EDGTCT&qs=PF&cvid=c9b2c1af374b40dcad6a7ef71ebc57fd&refig=b419f565f9bb4a8c93b8453a3eba4461&cc=US&setlang=en-US&elv=AXK1c4IvZoNqPoPnS%21QRLOO1UIuTgxU997oftyxnNgKevGu0yMELEGEiFY6K9k6GPbMQbPr4ww*quaC85AvlnYgbE5sVEmE7aB6SD%21SeiJXG&plvar=0&PC=HCTS

Us Too Warriors- Website to control sugar intake at Swansons reduced price:
Link: Swansons
or Go To
https://www.swansonvitamins.com/q?kw=gymnema+sylvestre

Us Too Warriors,

Bicalutamide: first lab results, nadir comes when?

I am using 150 mg casodex with metformin 1500mg & Avodart and proscar plus doxycycline and femara that blocks estrogen, hot flashes & breast pain. The Blog copied below describes the use in men with PCA and comments by other PCA men.

To Read More - Click on the Link:

Link: Blocks
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/143677191/bicalutamide-first-lab-results-nadir-comes-when
**********
Us Too Warriors,

Pain - CBD Hemp oil

I am going to recommend you try CBD Hemp oil. I have used it for the last year on my wife after 30 years of incapacitation with Fibromyalgia which produces unremitting pain that moved all over her body. She at 76 is having the best years of her life after the last 30 years (1990). The brand of CBD my wife and Jerry's wife used to benefit her arthritis pain is below (The price n is the best I have seen for 30mg strength: Squeeze the dropper of liquid under your tongue and hold it for a few minutes before swallowing. If it does not eliminate the pain totally it may reduce it or the amount of drugs you need . I would use it when the pain is bothering you.

It may produce loose bowels. My wife takes an over the counter pill(?) to control loose bowels

This is the bottle I ordered for Sue and this is a 5% discount Code - Coupon Code: GOLDFIVE

To Order - Click on the Link:

Link: CBD Hemp oil
or Go To
https://www.goldenappleorganics.com/Dr_Formulated_CBD_s/1176.htm
*
Us Too Warriors, See below for papers proving the usefulness of CBD Oil in PCa. Best peter
*
To Read More:

Click on the Links:

Link: "Usefulness1"
or Go To
http://rvaprostatecancersupport.org/PDF/06 22 20 PCa-CBD oil Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients a prospective cohort study.pdf

Link: "Usefulness2"
or Go To
http://rvaprostatecancersupport.org/PDF/06 22 20 PCa-CBD oil-Cannabinoids as anticancer therapeutic agents.pdf

Link: "Usefulness3"
or Go To
http://rvaprostatecancersupport.org/PDF/06 22 20 PCa-CBD-Cannabinoids as anticancer therapeutic agents.pdf

Us Too Warriors,

Baicalin

Recently, a steroid, Dexamethasone, has been shown to reduce the damage/death/time in hospital by about 30% by reducing the Virus cytokine storm.

This steroid is also used in hospice to reduce bone pain in advanced PCa. Cytokine storms are also present in Very advanced cancers causing multiple organ failures.

This steroid is a prescription drug that makes it hard to obtain unless you have a problem for which it may be prescribed.

On the other hand, Baicalin found in natural supplements like Chinese Skullcaps may fight the cytokine storm. It was one of the components of PC Spes, a combination of 8 natural agents which was helpful about the year 2000 for men with PCa. I have been using Chinese Skull Caps for a number of years (from Swanson) for PCa. I have attached a website describing its researched actions below. Check it out and decide for yourself if you think it is worthwhile. You know what I think.This steroid is also used in hospice to reduce bone pain in advanced PCa. Cytokine storms are also present in Very advanced cancers causing multiple organ failures.

This steroid is a prescription drug that makes it hard to obtain unless you have a problem for which it may be prescribed.

On the other hand, Baicalin found in natural supplements like Chinese Skullcaps may fight the cytokine storm. It was one of the components of PC Spes, a combination of 8 natural agents which was helpful about the year 2000 for men with PCa. I have been using Chinese Skull Caps for a number of years (from Swanson) for PCa. I have attached a website describing its researched actions below. Check it out and decide for yourself if you think it is worthwhile. You know what I think.

To Read More - Click on the Link:

Link: Baicalin
or Go To
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/baicalin

Us Too Warriors,

Please check out this webinar for news you might use for your health. This Saturday at 6:00 AM June 20 th

Join PCRI on June 20, 2020, at 9:00 AM PST for a discussion on Men's Health. This online event will feature ESPN's 32-time Emmy winning sports anchor, sportscaster, and prostate cancer survivor Vic Lombardi and Mark Moyad, MD, MPH from the University of Michigan Medical Center. This event will feature discussions on men's health topics and interactive live Q+A. You won't want to miss this one of a kind event. This event will be hosted on YouTube Live and our website PCRI.org.
Best Peter

To RSVP:

Click on the Link:

Link: "RSVP"
or Go To
https://mailchi.mp/pcri/we-are-live-streaming-the-mid-year-update-online-for-free-628236?e=dfb790b4b1

Us Too Warriors,

HERO Phase 3 Trial: Relugolix vs. Leuprolide Acetate for Advanced Prostate Cancer –

Summary:

Neal D. Shore, MD, FACS, Medical Director for the Carolina Urologic Research Center, presents the key aspects of the HERO phase 3 trial. The HERO trial looked at Relugolix, an oral GnRH receptor antagonist, versus Leuprolide Acetate for the treatment of advanced prostate cancer. He begins by going over the study design, patient demographics, and clinical characteristics. He then goes over some of the study’s key and secondary endpoints, all of which were met.

To Read More - Click on the Link:

Link: HERO
or Go To
https://grandroundsinurology.com/hero-phase-3-trial-relugolix-vs-leuprolide-acetate-for-advanced-prostate-cancer/

Us Too Warriors,

Prostatepedia - Effective June 15, Prostatepedia will become a free publication of the National Alliance of State Prostate Cancer Coalitions (NASPCC).

Attached below is the newsletter and you will be able to get it free in the future. I have been paying $86 per year to send it out to you over the years but now you can sign-up to get it for free as Dr. Meyers is changing the way it is available.
Best Peter

To Read More:

Click on the Link:

Link: "Prostatepedia"
or Go To
http://rvaprostatecancersupport.org/PDF/06 13 20 Prostatepedia_V5N8_9_AprilMay2020.01.pdf

Us Too Warriors,

Blocking the PD-1/PD-L1 Axis in Advanced Prostate Cancer: Are We Moving in the Right Direction?

I received an email from Fred Johnson, one of our members, about the use of this immunotherapy for treatment of pancreatic cancer successfully for Harry Reid (former leader of the Senate) in a passionate USE in small group 4 patients. It also has some small benefit in PCa if the cancer is advanced (Mutations & Mets) and it will be important to Identify the men it will help with the right mutations.
Best Peter

To Read More:

Click on the Link:

Link: "Moving"
or Go To
https://pubmed.ncbi.nlm.nih.gov/31032288/

Us Too Warriors,

This forwarded email is an offer for a free sample of light continence pads. I have not used or know if they are good but I sent away for the sample to find out. I find with age leakage can be more of a problem. I hope you do not have this aging problem.
Best Peter

To Get a Sample:

Click on the Link:

Link: "Sample"
or Go To
http://mdp.activehosted.com/index.php?action=social&chash=c4ca4238a0b923820dcc509a6f75849b.3&s=77c698e465e65e1f77f96d70ca2a316a

Us Too Warriors,

SEE the website below for agents you may want to investigate with your Doctor. If you have an unusual doctor who uses drugs off label you may find he will prescribe other drugs off label. I have 7 off label drugs and only one FDA approved, Casodex.. one of my off label drugs metformin acts on the mTor which is one of the pathways that grows Pten mutated PCa. Rapamycin (another drug for the mtor pathway) is FDA approved for kidney cancer but one of our members had good results with this for his mTor pathway for his mets now going on 12 years from a John Hopkins Clinic trial but it was not good enough for other men on the trial to get it FDA approved . But if you went to an oncologist who treats kidney cancer and PCa you may be able to get access to rapamycin for your PCa. It would be good to know if mTor is an active pathway for your PCa (Pten mutated). Always check the side effects of any drug you try.
Best Peter

To Read More:

Click on the Link:

Link: "Drugs"
or Go To
http://rvaprostatecancersupport.org/PDF/06 11 20 PCa-PtenTherapeutic targeting of cancers with loss of PTEN function.pdf

Us Too Warriors,

This is a paid ($150) opportunity to take part in a Survey - if you Qualify. See below for qualifications.

We are currently inviting individuals diagnosed with Prostate cancer and Caregivers of prostate cancer patients to participate in a discussion with us. We are interested in speaking with you about your experiences. I can assure you there are absolutely no sales involved. All information gathered will be used for research purposes only and will not be shared with anyone outside the research team. This is not a clinical trial and at no point will we try to sell anyone anything.
Best Peter

To Read More:

Click on the Link:

Link: Survey
or Go To
http://rvaprostatecancersupport.org/PDF/06 04 20 Prostate Cancer Flyer.pdf

Us Too Warriors,

A new FDA approved antiandrogen (Darolutamide) that may have advantages (primarily reduced fatigue and maybe progression) over Xtandi and Zytiga when added to ADT( Lupron). See website below for more information.
Best Peter

To Read More:

Click on the Link:

Link: Darolutamide
or Go To
https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-darolutamide-non-metastatic-castration-resistant-prostate-cancer

Us Too Warriors,

Check out this website below for a 10 minute video on ways to minimize some of the effects of ADT like fatigue etc. Some of these side effects apply to me now I am on Casodex Antiandrogen. I learned I need to spend more time in weight training. Also. I have recently heard from Dr. Drake ( Jerry Dean's Oncologist) that ADT does not make you react badly to Cov-19; but Chemotherapy like Taxotere ( which lowers the immune system) may make the reaction to Covid -19 worse. Fortunately, Jerry has just completed (earlyMay?) six rounds of treatment with some benefit in lowering his PSA .
Best Peter

To Read More:

Click on the Link:

Link: Minimize
or Go To
https://www.youtube.com/watch?v=efza9vq-cg8

Us Too Warriors,

I think Jerry Deans is going to add Fisetin to his Armour against PCa. I have attached the below paper for your consideration for adding it to your own Armour. It Blocks most of the cancer growth, invasion and metastasis pathways.

It is right up there with Curcumin and green tea in its actions.
Best Peter

To Read More:

Click on the Link:

Link: Fisetin
or Go To
http://rvaprostatecancersupport.org/PDF/06 03 20 PCa-Fisetin AMOUR for PCa biomolecules-09-00174.pdf

Us Too Warriors,

Us TOO is proud to offer Prostate Cancer Connections, a new series of educational and interactive webinars which will bring people together virtually and safely to access empowering, decision-making information and personal connections in a time of social distancing.

For the first of our three webinars, we are partnering with AnCan to offer a discussion around how and if men with prostate cancer should talk to their kids about why it could impact their lives.

Best Peter

Subjects:

The Talk Prostate Cancer Educational Forum - Webinar
June 30th, 2020 - 8:00-9.30 pm EDT

Panel
• Moderator: Dr. Alicia Morgans, Northwestern University Feinberg School of Medicine
• Medical Panelist: Dr. Ryan Berglund, Cleveland Clinic
• Father on Active Surveillance and His Son
• Low/Intermediate Father and Son
• Advanced Father and Son
• Father-Daughter with Inherited BRCA gene

To See the Brochure:

Click on the Link:

Link: Webinars
or Go To
http://rvaprostatecancersupport.org/PDF/06 03 20 AnCan UsTOO Webcast Brochure.pdfUPDATED.pdf

and to Register: Click on the Link:

Link: Register
or Go To
https://ustoo.wufoo.com/forms/the-talk-prostate-cancer-educational-forum/

Us Too Warriors,

Metformin aids in fighting cancer by reducu=ing blood sugar. However the Time release capsules may contain NMDA contamination which grows neuro cancers like and may grow PCa as neuro cancer. 5 generic companies are suspected. Regular release is OKay so far. See below

Best Peter

To Read More:

Click on the Link:

Link: Contamination
or Go To
http://rvaprostatecancersupport.org/PDF/06 02 20 Pharma and Marksans Pharma Ltd.pdf

Us Too Warriors,

RVA Us Too Warriors and family. The Nitric oxide (NO) molecule in our body has many helpful facets. I am going to state a few researched effects but there is much more to know. Aklso - Info for CoViD-19

Nitric oxide (NO) is a ubiquitous signaling molecule in the human body with well-known roles in many different processes and organ systems.

1. Nitric oxide (NO) is good for the heart
2. It helps Build Muscles and now there are muscle building supplements with Nitric oxide (NO).
3. You get more in your body by breathing in thru the nose as it is released from nasal passages and by humming between breaths.
4. It helps oxygen blood saturation if small Amounts of Nitric oxide (NO) are added to oxygen Breathed in for Covid therapy
5. Dark Chocolate (with low sugar) and Beets are a source of NO.

Info Prostate cancer

1. High levels of NO in blood are good for slowing this cancer growth and preventing CRPC.
2. See Paper attached below

Best Peter

To Read More:

Click on the Link:

Link: Nitric oxide
or Go To
http://rvaprostatecancersupport.org/PDF/05 29 20 Yang And Ying Of NO in PCA.pdf

You can buy strips on line to test your saliva first thing in the morning by put a drop on the strip (not put in mouth) to see if your diet need to be enhanced with more greens, beets and Dark low sugar chocolate etc. I tried to find them at Walgreens and CVS locally with no Luck. Search on line for "nitric Oxide Test strips" if you want to find them. By age fifty Nitric Oxide in the body has dropped 50% from the 20's. I do not know what it is at 80 but I will find out. And to eat the right foods See the below Link:

Click on the Link:

Link: Foods
or Go To
https://swfas.org/foods-boost-nitric-oxide-levels-naturally/

Us Too Warriors,

Please find analysis by Dr, Moyad from Us Too International on possible treatments to mitigate Covid -19 Virus in the nose and some on going analysis of possible on going clinical trial treatments with nasal spray (etc) to reduce Virial load and contamination with salt nasal sprays etc. This is unproven but may prove useful. Dr. Moyad has not been my favorite for analysis of supplements that aid in PCa treatment as he tends to have negative attitude and often recommends too little or says things do not work in studies that used too little to be effective but in this case I think he has put a lot of thought into these investigations on studying Covid -19. I hope you find it useful.
Best Peter

To Read More:

Click on the Link:

Link: Covid-19
or Go To
http://rvaprostatecancersupport.org/PDF/05 28 20 Conquering COVID Part 2.pdf

Us Too Warriors,

The paper below suggests metformin often used by diabetics to reduce blood sugar can slow PCa. High Sugar levels grow cancer.
Best Peter

To Read More:

Click on the Link:

Link: Metformin
or Go To
http://rvaprostatecancersupport.org/PDF/05 28 20 PCa-Metformin in Chemotherapy-naive Castration-resistant Prostate.pdf

*****
Us Too Warriors,

Below is the list of the supplements I take and that I am sending out to my Brothers. All marked with * are most important.
Best Peter

To See the List:

Click on the Link:

Link: List
or Go To
http://rvaprostatecancersupport.org/PDF/05 25 20 My Supplements.pdf

***************************************************
Us Too Warriors,

All : Attached below is the interpretation of the history of our cancers and the way to proceed for my two brothers and myself..
Best Peter

To Read More:

Click on the Link:

Link: History
or Go To
http://rvaprostatecancersupport.org/PDF/05 23 20 Brothers.pdf

*
Us Too Warriors,

I hope your diet follows along the Mediterranean diet for PCa as we and Dr. Meyers has long recommended and now see below how it may help your aging brain too!
Best Peter

To Read More:

Click on the Link:

Link: Mediterranean diet
or Go To
http://rvaprostatecancersupport.org/PDF/05 20 20 Low flavonoid intake associated with Alzheimer.pdf

*
Us Too Warriors,

I have been using Fisetin from Swanson to put my PCa in remission. I have mention this in the past at meetings but the paper I requested from the Author several months ago below has just Arrived! It is below for your information. Casodex is the Anti-androgen I am using now for 2 1/2 years to trigger my cancer remission.
Best Peter

To Read More:

Click on the Link:

Link: Fisetin
or Go To
http://rvaprostatecancersupport.org/PDF/05 17 20 PCa-Fisetin.pdf

*
Us Too Warriors,

Natural Product MDM2 Inhibitors: Anticancer Activity and Mechanisms of Action - See Below
Best Peter

To Read More:

Click on the Link:

Link: Inhibitors
or Go To
http://rvaprostatecancersupport.org/PDF/05 15 20 PCa-Natural Product MDM2 Inhibitors.pdf

*
Us Too Warriors,

Exploring why some COVID-19 patients lose their sense of smell!

Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age.

Best Peter

To Read More:

Click on the Link:

Link: Smell
or Go To
https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.0c00210

*
Us Too Warriors,

If you are part of the 50% of Men with TMPRSS2-ERG Fusion Mutated PCa (as I & 2 brothers are), you will benefit from Avodart & Finasteride to fight PCa and The Virus!!!
Best Peter

To Read More:

Click on the Link:

Link: TMPRSS2-ERG
or Go To
http://rvaprostatecancersupport.org/PDF/05 13 20 TMPRSS2.pdf

*
Us Too Warriors,

How many Papers have I sent you to get Vitamin D Blood tests and take supplements between 4000 IU to 10,000 IU with the Idea of getting blood levels above 65 ng/ml in the blood with a 25 OH vitamin D test???? My Guess more than 50 emails.

Here is One More email showing deaths are much higher in People with low Vitamin D and COVID-19- Which is common in nursing homes and people with darker skin and in end of winter February, March, April and into May!!! and further north with less UV rays to make vitamin D from sunshine - Also more PCa in the north from low D

Now you now why I keep my wife's and my vitamin d at 100 ng/ml of blood and take vitamin K 1 & 2 to keep calcium out of my blood vessels along with lower calcium intake. Please read the following about Low vitamin D and Virus deaths:
Best Peter

To Read More - see the Two Links:

Click on the Link:

Link: Vit D
or Go To
http://rvaprostatecancersupport.org/PDF/05 12 20 Vitamin D levels appear to play role in COVID.pdf

Link: Neuroscience
or Go To
https://neurosciencenews.com/neuroscience-topics/neuroscience/

*
Us Too Warriors,

When I first learned of my Metastasis 2 !/2 years ago I asked my doctor about getting Xofigo, a nuclear injection that goes to bone and radiates the bone marrow cancer in situ. He told me it is only recommended if there is bone pain which fortunately I did not have. The study below indicates that marrow damage can be as high 45% in PCa patients, especially those that have already been treated by external radiation. See below
Best Peter

To Read More see the Two Links:

Click on the Link:

Link: Xofigo
or Go To
https://www.ncbi.nlm.nih.gov/pubmed/32140364

Link: Bone Marrow Failure
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757096/

*
Us Too Warriors,

BELOW is a SUMMARY of the many ways to fight the Covid 19 (and cancer) that have been sent out piecemeal

1. Prevent Strokes which may cause Death in COVID and help stroke recovery Vitamin C~ 3000 to 6000 mg/day; Vitamin D3~4000 to 10,000 IU : Magnesium ~500 to 1,000 mg (too high may cause loose stool), ZINC~20=>30mg (all per day) This amount of Zn helps with stroke recovery but more can be damaging. Fish oil ~ 3gm/day, Dark Chocolate~>80% best: CO Q10~100 to 300mg to help protect the heart which will be under great strain in the battle

2. LOWER Hypoxia Inducible factor -1 from damaging the lungs(I recommend 3 to 6 pills of each at what dose provided with Red Korean Ginseng, Apigenin, Berberine, Luteolin, and Quercetin

3. Fight cytokine Storm- Curcumin and Green Tea to fight NFkB and IL-6 (These are among the Best PCa fighters I use at 9 to 12 pills per day)

4.Melatonin- Raise the immune system - 10 to 50mg per night and you should increase in dose as you have covid symptoms.

5. Metformin - Is a Drug used in Diabetes to control blood sugar 500mg should be taken after every meal to lower blood sugar but you should have a blood sugar above 80 so you do not experience low glucose.

Best Peter

One question that has not been truly answered is why infants and children under the age of nine do not seem to suffer any severe symptoms upon COVID-19 infection. It is I have been sending ways to battle COVID as I found it, but know I am going to summarize it so you can have it all together. It is understandable why older patients may be more susceptible to higher risks, but what spares young children? Why are young adults without comorbidities also suffering from pneumonia as a result of COVID-19 infections?

Take a look at the following chart showing the fatality rate according to age groups:
COVID-19 fatality rate by age
Link:

Link: Chart
or Go To
https://www.worldometers.info/coronavirus/coronavirus-age-sex-demographics/
Best Peter

To Read More

Click on the Link:

Link: Covid 19
or Go To
http://rvaprostatecancersupport.org/PDF/05 06 20 Covid 19 Cancer.pdf

*
Us Too Warriors,

Kill 2 Birds with one Stone.

Wormwood for PCa and it may be good to fight Covid 19
Best Peter

To Read More

Click on the Link:

Link: Covid 19
or Go To
http://rvaprostatecancersupport.org/PDF/05 4 20 COVID19 - Artemisia+annua+against+viruses Swanson =Wormwood.pdf

Link: Cancer
or Go To
http://student-doctor.dryarnell.com/2013/01/29/artemisinin-and-prostate-cancer/

*
Us Too Warriors,

This information below was published in Richmond paper which may you have seen. i believe I sent information about the use of Vitamin C for virus which i take 3000 mg per day along with high dose Vitamin D ( >10,000 IU) and Zinc (40 mg) but Infusion of Vitamin C ~ 15 grams at a time by IV is much better. I have been in contact DR Fowler at VCU who says that this infusion should help in the COVID 19 fight.

Remind me ... what is the role of Vit C in PCa?

Aha... nice to see my perception from weeks ago reflected finally even in conservative Richmond Times Dispatch! (Re: Cytokine Storm)

"There’s a growing belief in the medical community that it isn’t the coronavirus itself that kills a patient, but the patient’s extreme inflammatory response. The immune system floods the cells with proteins called cytokines. When the body produces a rush of cytokines — known as a cytokine storm — blood vessels become weak, allowing fluid to leak in and fill the lung cavities. This can shut down organs and make recovery difficult.
Best Peter

To Read The Richmond Times-Dispatch Article:
A Richmond doctor’s dramatic story of COVID-19 infection, hospitalization and survival.
Click on the Link:

Link: Article
or Go To
https://www.richmond.com/special-report/coronavirus/a-richmond-doctor-s-dramatic-story-of-covid-19-infection-hospitalization-and-survival/article_750722ad-7918-544d-bc4d-798d456033f6.html

*
Us Too Warriors,

I use the VCU libraries for my own cancer searches and for talks I give at our meetings. It looks like you will be able to get material(cancer papers) sent to your email from ILLAID, the VCU inter-library request engine if you join to do your own searches for ways to fight your cancer. I think it may be $50 donation per year to join and get this benefit.?
Best Peter

For More Info - Click on the Link:

Link: Cancer Papers
or Go To
https://guides.library.vcu.edu/request/

Go to website to find how to enroll and donate to become a friend of VCU libraries which gives you the ability to request 10 papers per year. Best peter
Link: 10 Cancer Papers
or Go To
https://www.library.vcu.edu/about/giving/get-involved/friends/

*
Us Too Warriors,

Many of the supplements I have recommend to fight PCa also Protect your LUNGs from damage from COVID19.

I am going to list the easy ones that cab be obtained online from LEF.org and Swanson etc. These are also good to prevent growth of PCa as I have suggested over the last 15 years. You will recognize many of them. Some AGENTS break down HIF1 and some keep HIF1 from forming and some prevent accumulation.

See AGENTS Below
Green Tea, Curcumin, Apigenin, Berberine, Silibinin, Urosilic Acid, Resveratrol , Quercetin, and Luteolin. The amount I take would be at least 3 pills a day which I take for all above except I take 12 curcumin and 9 green tea each day. do you best to help yourself you can.
Best Peter

To Read More - Click on the Link:

Link: Supplements
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908043/

* Us Too Warriors,

Try adding these to healthy food to make them more health See below.
Best Peter

15 Impressive Herbs with Antiviral Activity

Since ancient times, herbs have been used as natural treatments for various illnesses, including viral infections.

Due to their concentration of potent plant compounds, many herbs help fight viruses and are favored by practitioners of natural medicine.

At the same time, the benefits of some herbs are only supported by limited human research, so you should take them with a grain of salt.

Here are 15 herbs with powerful antiviral activity.

To Read More - Click on the Link:

Link: Herbs
or Go To
https://www.healthline.com/nutrition/antiviral-herbs

*
Us Too Warriors,

Melatonin is available over the counter for supplement from online companies and local stores. I have used it for years at about 40mg to 60 mg per night. Studies in Italy reported remission in stage 4 in a variety of cancers. It reduces IL6 inflammatory factor that promotes PCa and IL8 and VEGF that promotes blood supply to cancer to speed growth. I think it has helped put my cancer in remission. It keeps the blood vessels from being leaky which makes damage to the lungs worse during COVID-19. It is not very expensive. My wife,Sue takes up to 80 mg per night which have with many made aids put her fibromyalgia(caused by lack of restful sleep) in remission with no pain (to day she said I did not get her the boxes of pain patches ( = 40 patches every two weeks) for the first time in 30 years - She is now getting 8 to 9 hours sleep every night with waking between 3 to 4 AM to take 4 more melatonin and other sleep aids to sleep from 8:30 to 9 AM.

See what works for you to fight PCa and COVID-19.

To Read More - Click on the Link:

Link: Melatonin
or Go To
http://rvaprostatecancersupport.org/PDF/04 14 20 1-s2.0-S0024320520303313-main (1).pdf

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Us Too Warriors,

As My PSA rose from 2.2 in Dec 2014 to 12.2 Dec 2017, I had two MRI tests to try to see if I was developing METs.

All these MRI detected was a slight growth at the Amoratasis in the prostate bed where the bladder and urethra are sewed back together.

My doubling time dropped from 18 months to 5 months during this time which is what pushed me to get the MRI tests. What I did not know was that:

The MRI that was used only covered the prostate bed and did not pick up lymph node mets very well. But I was fortunate because the AXUmin Pet imaging scan was approved by late Sept. 2017 and VCU had it available by Mid November and I was tested by early December. This test showed a MET in my right hip bone and multiple lymph nodes in my pelvis. An extended MRI was then done that showed the met in my hip too.

So you need to look in all places to find your mets, The Axumin test is supposed to be used if you have Cancer recurrence after surgery or radiation so I had the test 19 years after recurrence because I had been so successful in slowing my cancer with avodart, metformin , doxycycline, and melatonin and supplements like green tea, curcumin, berberine. apigenin and Quercetin, rosemary etc,etc. I now know that my mutation TMPRSS2-ERG fusion is particularly responsive to Avodart which may apply to about 50 % of men with PCa which makes it worth the try ( I learned this just yesterday in my research.)

Best - stay well sheltered in Place with mask and gloves as you go out for food.

Peter
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Us Too Warriors,

Below is the conclusion of the very complicated paper copied below which suggests Lupro or casodex/xtandi. may be bad choices for your cancer and may drive it to grow and become a neuro active cancer.

I do not know what this means but it suggests to me that a BAT treatment with alternating high and low testosterone may be worth looking into. I am looking for natural supplements to fight SPINK1 mutation specifically but I have not found any yet but I will still be looking PCa.

Have A Blessed Easter, Peter

Conclusively, our findings emphasize that administering PCa patients with AR targeted therapies may result in increased SPINK1 levels accompanied by upregulation of NE markers, potentially promoting the development of treatment-related NEPC (Fig. 8). Although, androgen ablation therapy is a well-established and highly effective treatment for PCa patients, resistance ultimately ensues. Understanding resistance mechanisms to ADT and subsequent AR therapies will eventually lead to more effective treatment strategies to improve outcomes for patients developing AR independent disease.

To Read More - Click on the Link:

Link: PCa-Androgen
or Go To
http://rvaprostatecancersupport.org/PDF/04 12 20 PCa-Androgen deprivation upregulates SPINK1expresion in PCa.pdf

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Us Too Warriors,

The below links and more that suggest it may be possible to reactivate the P53 anticancer protein with natural agents.

Part of the job is to find the easiest ones to easiest access on line or which you may already on hand- For example, I have lemon balm growing wild in my Garden that fights P53 thru its being HARMINE

To Read More - Click on the Links:

Link: Harmine
or Go To
http://rvaprostatecancersupport.org/PDF/04 12 20 PCa-P53 by use ofHarmine Inhibits Angiogenesis and supresses Tumor growth.pdf

Link: Harmine Website
or Go To
https://en.wikipedia.org/w/index.php?title=Harmine&oldid=949603370

Link: Ursolic Acid
or Go To
http://rvaprostatecancersupport.org/PDF/04 12 20 ol-17-06-4761.pdf

Link: Ursolic Acid Web 2
or Go To
https://www.spandidos-publications.com/10.3892/ijo.2013.2101

Link: Curcumin
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC556252/

*

Us Too Warriors,

I have been using 150mg /day casodex/day, 100 mg of Doxycycline/d, 1500mg of Metformin/d, dostinex 0,5mg/week and Calcitriol 0.5mcg /d (This is the maximum amount of calcitriol I can take on a low calcium intake diet to keep my calcium in my blood in safe range< , 10.8 in my blood). Plus all my many supplements that have put my cancer in remission.
The information that follows is information I found which discusses how Calcitriol reacts favorably with TMPRSS2-ERG Mutations to fight PCa.
For your information:
Best Peter

To Read More - Click on the Links:

Link: Vit D
or Go To
http://rvaprostatecancersupport.org/PDF/04 10 20 Revealing Vitamin D Pathways to Prostate Cancer Prevention and Treatment.pdf

Link: 2 Vit D
or Go To
http://rvaprostatecancersupport.org/PDF/04 10 20 Vit D 17968-262380-4-PB.pdf
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Us Too Warriors,

I just sent this information that follows to my family. I think you may benefit from my experience so I am sending it to you.

"The Paper below cites these supplements to decrease ERG production so our (MOON Men 3 brothers with PCa & other family members?) TMPRSS@-ERG Fusion gene mutation is less aggressive . Supplements are in bold I take ==>quercetin, fisetin, luteolin, apigenin, curcumin, resveratrol, genistein, silibinin, kaempferol, epigallocatechin-3-gallate (EGCG=Green tea), tocotrienols, sulforaphane, ginsenosides, ursolic acid, berberine, honokiol, xanthohumol, oridonin, and tannic acid. I Take 15 of the 19 agents. You might think this is overKill, but I have been in remission from metastatic bone cancer for 29 months now after 26 years with PCa. I take 3 pills of most of these except I take 12 Curcumin and 9 green tea pills per day. "

This mutation occurs in more than 50 % of men diagnosed with PCa. Do you know your family germline situation/somatic Mutations???
Best Peter

To see More - Click on the Link:

Link: ERG
or Go To
http://rvaprostatecancersupport.org/PDF/04 08 20 cells-09-00460-v2.pdf
*

Us Too Warriors,

I have used my contacts at VCU to find out VCU's efforts to understand the treatments related to COV-19, Pneumonia and cancers.

This is what I have found out:
1. The VCU infectious disease department has shown That Vitamin C (I.V. infusion) has shown that it increases survival from pneumonia sepsis by 50% which is also what is a cause of death in COV_19 VIRUSby decreasing HIF-1 in the blood.
2. I reviewed a paper for Nutrition and Cancer Journal several years ago which showed that an infusion of Vitamin C increases survival for stage 4 Lung cancer by more than a year compared to the control group with only standard of care without Vitamin C Infusion.
3. Vitamin C inhibits HIF-1 = (Hypoxia Increase Factor) which causes cytokine storm in Pneumonia and Covid VID-19 Virus when lungs fill with fluid so that oxygen can not get in and it causes blood vessel growth to make Cancer grow faster by getting more fuel from the blood.
4. The Nobel Prize in Physiology in Dec 2019 was AWARDED to 3 scientists who have been studying HIF-1 for the last 30 years showing its importance in cancer and heart conditions.
5. Below are websites Discussing HIF-1 in cancer and other disease conditions for your information from the Nobel Prize Scientists.

https://www.youtube.com/watch?v=2I3oluioJU0&feature=emb_rel_end
https://www.hopkinsmedicine.org/health/video/gregg-semenza-of-johns-hopkins-medicine-on-hif-1
https://www.youtube.com/watch?v=OykDa17A9d4
https://www.youtube.com/watch?v=B_KBgSXUWoM
6. Green Tea extract (9/d) and Super Bio Curcumin (12/day) are what I have used for 15 years from LEF.org to lower my HIF-1 along with 3000mg vitamin C7. 7. 7. Wear a face cover when out.!!!!!
Best Peter

To go to the above Websites - Click on our Links:

Link: 1.
or Go To
https://www.youtube.com/watch?v=2I3oluioJU0&feature=emb_rel_end

Link: 2.
or Go To
https://www.hopkinsmedicine.org/health/video/gregg-semenza-of-johns-hopkins-medicine-on-hif-1

Link: 3.
or Go To
https://www.youtube.com/watch?v=OykDa17A9d4

Link: 4.
or Go To
https://www.youtube.com/watch?v=B_KBgSXUWoM

Us Too Warriors,

As our understanding of cancer continues to grow the role of our underlying genetics has moved to the forefront of both research and clinical practice. Anybody diagnosed with cancer will find a time that they will need to understand their Hereditary Genetics, also referred to as their Germline Genetics.

Germline genetics are the genes that are passed down to you by your parents, one half from your biological mother and one half from your biological father. In many cancers, including prostate cancer your germline genetics can change your risk for developing cancer, change your risk for how aggressive your cancer might be and can also factor into the possibility that certain treatments might or might not be effective for you.

Given the importance of knowing about your germline genetics, Cancer ABCs wants you to know that if you have prostate cancer there is currently a genetic company, Invitae that is offering you an opportunity to have your germline genetics tested for free. They will also offer you, for free, access to a genetic counselor who will review with you your test results and help you understand what they might mean for you and your family.

To Qualify for these free services, you must have either:

-Gleason Score 6 or less (age at diagnosis 55 years or younger)
-Gleason score of 7 or greater (any age)
-Metastatic PC (any age)
-There are a few more criteria but this is most of them.

Check out the link below for more info.

When you contact them, please let them know that you learned about this opportunity through Cancer ABCs.
Best Peter

To see More - Click on our Link:

Link: Invitae
or Go To
https://www.invitae.com/en/detect-hereditary-prostate-cancer/?fbclid=IwAR0ZsVAY9dKyBHkFsmhG7wKWsgOZIigKFJ4Hz_8ajIDZXSiO5Mii6Rr9FBA

Us Too Warriors,

I have studied how to prevent Hypoxia cancer spread as it grows to the point that it needs blood vessels to get enough oxygen to grow /spread and the hypoxia also occurs in the lungs from The Virus and pneumonia as the lungs fill with fluid during sepsis/Virus cytokine storm to produce the high amounts of HIf-1that causes death

The supplements , I recommend to my cancer Support Group use Berberine, Apiginen and Resveratrol to block/breakdown hipf-1from Swanson (call 1-800-824-4491 (7am— 12 AM)

Attached below is a paper "Natural Product-Based Inhibitors of Hypoxia-Inducible Factor-1 (HIF-1)"

Also, My University- Virginia Commonwealth University - Tested the use of High Dose IV vitamin C ~ 15 grams at a time to lower Hypoxia in Sepsis to the point that survival is doubled from 30% to 60%. Vitamin C intake from Fruit and supplements. (I take 3000mg per day by 3 -1000mg pills) plus citrus fruit. Many of the people with low vitamin C and potassium are dying from this VIRUS.
Best Peter

To see More - Click on the Link:

Link: Natural
or Go To
http://rvaprostatecancersupport.org/PDF/03 30 20 Natural_Product-Based_Inhibitors_of_Hypoxia-Induci.pdf

Us Too Warriors,

Family and friends, My casodex treatment has raised my Testosterone to 1600 ng/ml blood level.

This video attached suggests that 2000 to 3000 ng/ml is a good level to shoot for so I have added Horny Goat weed, Tribulus, and fenugreek supplements to raise T. I also take avodart and proscar to to lower DHT which also raises my T. I found at age 60 with BCR of the cancer (year =2000) when my T = 475 and DHT = 40 that when I went on proscar my after 3 months my T=525 and DHT < 5. From 2000 to 2013 my PSA <1.0 on proscar, avodart, doxycycline ,dostinex and high dose active vitamin D. Since then in Dec 2017, I had a PSA =12.2 with multiple lymph node mets and bone met in right hip , I added Casodex and metformin Along with 70+ different supplements per day and my PSA = 0.026 Feb 2020. Cancer in remission I think? See video below from John Hopkins and U of Washington on high T treatment.. I found recently that my germline mutation is TMPRSS2-ERG fusion with a high level of ERG production which makes it less favorable. This mutation is a hormone testosterone growth sensitive. This mutation my make one more prone to Pten somatic mutation prone as hinted at in the cancer literature. See the Test results of the Video below as I couldn't figure out how to copy the video for you
Best Peter

To see More - Click on the Link:

Link: Testosterone
or Go To
http://rvaprostatecancersupport.org/PDF/03 28 20 Testosterone Replacement in the Treatment of Advanced Prostate Cancer.pdf

Us Too Warriors,

See Below for spices in your Battle. Note that Licorice should be use as Deglycerized LIcorice =DGL Licorice. This keeps the sodium level low so blood pressure is not raised or damage the kidneys.

Beta Glucans is a supplement from mushrooms that fight PCa (I have used for years) that helps the immune system in the fight. Elderberry and Zinc along with curcumin and green tea also help.

Show this to the cook in your family- Use most of these herbs in my stir fries or others as supplements = Cats Claw, DGL, Olive Leaf, Elderberry Liquid/Lonzengers , Astragalus.
Best Peter

To see More - Click on the Links:

Link: Herbs
or Go To
http://rvaprostatecancersupport.org/PDF/03 25 20 10 Antiviral Herbs to Naturally Fight Infection.pdf
Link: Kudzu
or Go To
http://rvaprostatecancersupport.org/PDF/03 28 20 COVID=19 KUdzu for coronaupdate.pdf
Link: Nutrition
or Go To
http://rvaprostatecancersupport.org/PDF/03 25 20 Nutritional preparedness recommended when facing viral epidemics.pdf
Link: Chloroquine
or Go To
http://rvaprostatecancersupport.org/PDF/03 25 20 Chloroquine for COVID.pdf

Us Too Warriors,

If use these drugs for a heart condition beware of the possible problem See Below .

To see More - Click on the Link:

Link: Neuroscience
or Go To
https://neurosciencenews.com/neuroscience-topics/featured/

Us Too Warriors,

Hydroxychloroquine and Chloroquine - There are issues to consider before the use of these drugs - the side effects may be worse than the disease!(Attachments below)

To see More - Click on the Link:

Link: Hydroxychloroquine and Chloroquine
or Go To
http://rvaprostatecancersupport.org/PDF/03 24 20 s12936-016-1391-6.pdf

Us Too Warriors,

Check out this paper to find supplements to help you fight the CYTOKINE STORM and the PI3K-AKT-mTOR PCA cancer pathways. Go on Amazon to search to find sources for them like Swanson etc.

To see More - Click on the Link:

Link: Flu
or Go To
http://rvaprostatecancersupport.org/PDF/03 24 20 COVID-19 GENE Nutrion Paper ANNE for Virus and PCa.pdf

Us Too Warriors,

Below are information Changes that may occur as the Pandemic gets worse.
Best Peter

COVID-19 Pandemic Rearranges Oncology Practice, Policies at Seattle Cancer Care Alliance
Danielle Ternyila - Published Online:1:00 PM, Fri March 20, 2020

As the Coronavirus disease 2019 (COVID-19) pandemic evolves, healthcare providers in the oncology realm are faced with a number of unforeseen challenges requiring immediate attention and swift changes in policies. Experts at the Seattle Cancer Care Alliance (SCCA) shared their insights and advice with the public in a recent article to demonstrate how they have adapted to provide the most optimal care for patients with cancer in light of the COVID-19 outbreak.

For Morer Information - Click on the Link:

Link: Oncology Practice
or Go To
https://www.targetedonc.com/news/covid19-pandemic-rearranges-oncology-practice-policies-at-seattle-cancer-care-alliance?p=1

Us Too Warriors,

This test is for men with advanced cancer with a rising PSA or CRPC or metastasis. These conditions should make it approvable by insurance if you have a tissue biopsy. If no biopsy, you will have to see what you can negotiate a for blood liquid biopsy test cost with the company. However, the liquid test is being submitted for FDA approval which may come through this year?? So Before you read all the details see if applies to your cancer situation

Websites follow for you to GOOGLE - see the link below

To see More - Click on the Link:

Link: Metastasis
or Go To
http://rvaprostatecancersupport.org/PDF/03 19 20 advanced cancer with rising PSA or CRPC.pdf

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COV-19 Virus

RVA - Us Too Warriors:

(COV-19 Virus)

Please see the LEF recommendations for the COV -19 Virus. I take all of the supplements and Metformin prescription routinely for my cancer except Cimetidine so they are doing double duty on COV-19.

Check out this website for agents to help reduce the problem. A word to the wise, the use of Cimetidine ( in Tagamet) should be restricted to the early stages of just a cough of the Virus as it may make the cytokine storm worse if used when fever occurs

To Read More - Click on the Links:

Link: COVID-19
or Go To
http://rvaprostatecancersupport.org/PDF/03 18 20 COVID-19-Consider Cytokine Storm syndromes and immuno suppression Lancet.pdf

Link: Life Extension
or Go To
https://www.lifeextension.com/protocols/infections/2019-novel-coronavirus-sars-cov2-covid-19?sourcecode=INC210E&utm_medium=email&utm_source=misc&utm_campaign=coronavirus-INC210E-0310&utm_content=article2-readmore&M_BT=49905301

Link: Influenza
or Go To
https://www.lifeextension.com/protocols/infections/influenza

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Great response to treatment from Br-DIM and calcitriol

RVA - Us Too Warriors:

(TMPRSS2-Erg)

This will Explain my great response to treatment. BR-DIM is an over the counter natural treatment that works . Calcitriol is a prescription of the active form of Vitamin D that Dr. Snuffy Myers recommended which I have been using since about 2008 ( or which I want to thank him most profusely!!!) Calcitriol must be used carefully as to high a dose can cause dangerous calcium levels in your blood that can cause heart issues. I found by titration I could handle one pill a day of Calcitriol and keep my blood calcium near the max normal blood level which I have followed since 2008. At this time I would suggest that you consider one pill every other day with BR-DIM to see how your PSA responded and your Calcium levels went for a month or two.

To Read More - Click on the Links:

*****
Vitamin D and Influenza—Prevention or Therapy?

Link: Vitamin D
or Go To
http://rvaprostatecancersupport.org/PDF/03 11 20 PCa-Vitamin.pdf

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Androgen receptor and gene network: Micromechanics reassemble the signaling machinery of TMPRSS2-ERG positive prostate cancer cells

Link: Micromechanics
or Go To
http://rvaprostatecancersupport.org/PDF/03 11 20 PCa-TMPRSS2-ERG positive prostate Androgen receptor and gene network.pdf

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Inactivation of AR/TMPRSS2-ERG/Wnt signaling networks attenuate the aggressive behavior of prostate cancer cells

Link: Inactivation
or Go To
http://rvaprostatecancersupport.org/PDF/03 11 20 PCa-TMPRSS2-ERG.pdf

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1α,25-Dihydroxyvitamin D3 Inhibits Growth of VCaP Prostate Cancer Cells Despite Inducing the Growth-Promoting TMPRSS2:ERG Gene Fusion

Link: D3
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850246/

***********************************************************************************************

Flu Like Symptoms

RVA - Us Too Warriors:

If you have not gotten a flu shot this winter

If you have not gotten a flu shot this winter, please do before coming to our next meeting on March 19, 2020. The flu is still strong in Va. and most of the people in Virginia checked for Cov-19 have had the Flu!! Also, let's switch to elbow bumps instead of handshakes to prevent spread. We do not need to sit next to each other in the meeting's chairs- Think you are in grade school and the person next to you has the cooties.

Please do not come to the meetings if you are sick with a cold or flu like symptoms.

Below is an advertisement From Swanson for supplements that help with respiratory breathing to counter the Virus. I am presently taking 6 of them for PCa as follows:

Astragalus, Quercetin, Bromelain, Feverfew, Oregano, and Coleus Forskohlii

To Read the Article - Click on the Link:

Link: Swanson
or Go To
https://www.swansonvitamins.com/blog/lindsey/herbs-for-respiratory-health

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Fatigue

RVA - Us Too Warriors:

Fatigue is a common symptom

Fatigue is a common symptom from cancer treatments especially advanced cancers and if on ADT Lupron and some antiandrogens like Xtandi.

Consumer Labs which analyzes supplements for purity and reliability of the dose content also discusses their use to help reduce fatigue. (See below)

To Read the Article - Click on the Link:

Link: Fatigue
or Go To
http://rvaprostatecancersupport.org/PDF/3 4 20 Supplements to Increase Energy.pdf

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COV-19 Virus

RVA - Us Too Warriors:

Supplements Which Fight More Than One Disease

I always like supplements which fight more than one disease so look at this websites for discussion of supplements to block COV-19 Virus.

You will find many choices to fight the many viruses - Vitamins B6 and D3 will help also.

See paper below Best Peter

To go to the Websites - Click on the Links below:

Link: Supplements
or Go To
https://www.studiobotanica.com/coronavirus-and-herbs/

Link: Supplements2
or Go To
https://www.carahealth.com/health-articles/immune-food-allergy-infection/natural-medicine-preparation-for-coronavirus

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Cell Damage/Inflammation Damage

RVA - Us Too Warriors:

Lactate Dehydrogenase

Lactate Dehydrogenase in the blood is a sign of cell damage/inflammation damage which is released into the blood and can occur from the damage/inflammation from cancer.

One thing to be aware of is do not do heavy workouts near the days of the blood test as the muscle cell injury will release LDH into the blood. Also avoid lactate added to food - I have seen it as additive to baked goods - do not buy them. Vitamin C supplements may lower LDH,

If LDH values are dropping with Chemo treatment it may be a sign it is working!!!

See paper below Best Peter

To Read the Article - Click on the Link:

Link: Cell Damage/Inflammation Damage
or Go To
http://rvaprostatecancersupport.org/PDF/3 2 20 1-s2.0-S1558767319302253-main.pdf

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Virus

RVA - Us Too Warriors:

CV-19 Virus

CV-19 virus is spreading so as many of us have a few years on us and other health issues. Precautions developed for Mers and Sars virus may help as general ways to reduce viral load. Below is an injectable antivirus developed by Bayer INc for past viruses which may help now? It consists of aspirin in combination with with two aminos acids ( Lysine and Glycine). I have found Lysine at Walgreens and Glycine at the Vitamin Shoppe. My plan is to take low dose aspirin and each of the amino acids a couple times a day as prophylactic treatment. And if I have symptoms of the virus. I will up my dose of aspirin and amino acids to try to prevent dangerous cytokine storms produce by heavy viral load. A word of caution - aspirin may produce bleeding in heavy doses and be injurious to kidney function. Lysine has long been used as an antiviral treatment for lip cold sores virus. All the Best. And keep your powder dry in this fight. peter

To Read the Article - Click on the Link:

Link: Coronaviruses
or Go To
http://rvaprostatecancersupport.org/PDF/2 28 20 Coronaviruses.pdf

*****
Heart IQ

RVA - Us Too Warriors:

These Videos are to raise your Heart IQ so you can better work with your Doctor's to keep your heart function well.

I know they raised my Heart IQ as I try to decide how to make my "SICK sinus node" work better with my Doctors' Help. As we age, it is not unusual for heart issues to arise. The ADT treatment for PCa may make this happen too. Heart attacks for men who already have heart problems may be 2 to 3times higher with ADT PCa treatment especially in the first year after diagnosis and starting on ADT =Lupron. Moreover , Lupron drives men towards metabolic syndrome with increased weight, fatigue resulting in less exercise and muscle loss (Heart is a muscle!) and towards diabetes which is bad for the heart.

Check Out the following video websites By Dr, John Campbell on YouTube to educate yourself. Dr. Campbell has many more (1200) YouTube Videos on Many Health Problems for you to see to educate yourself.

To Watch the Heart IQ Videos

Click on the Links:

Link: Cardiovascular System 1, Heart, Structure and Function
or Go To
https://www.youtube.com/watch?v=VWamhZ8vTL4

Link: Cardiovascular System 3, Heart, electrical system
or Go To
https://www.youtube.com/watch?v=MPZ_Am4HgQA

Link: Intro to EKG Interpretation - Waveforms, Segments, and Intervals
or Go To
https://www.youtube.com/watch?v=gvutn7fYvI0

*

Back to my PSA.

RVA - Us Too Warriors:

Metformin and Quercetin

I hope you can make the meeting Thursday at 7 PM. Back to my PSA. It was scary as I expect it to double based on the previous rise 4 months ago when the doubling time was 5 months when in October it went to 0.025 from June of 0.015. So In February, I expected it would approach 0.050, so it was really scary!!! (One reason is My general practitioner will continue to supply my prescriptions only as long as the PSA does not go above 0.1)
Really scary!!! until I found out it went up so little to only 0.026 which is a doubling time of 6 YEARS!!! HALUEYA!!!

See the attachment below to see how Metformin and Quercetin work together to block an important pathway of cancer growth and may be a contributing factor for my success in Keeping MY PSA down.

To Read the Article - Click on the Link:

Link: Metformin and Quercetin
or Go To
http://rvaprostatecancersupport.org/PDF/2 19 20 PCa-Metformin combined with quercetin.pdf

*****
Alternating High Testosterone and Lupron shots

RVA - Us Too Warriors:

The Alternating High Testosterone and Lupron shots in clinical trials are starting to be reported with positive results at John Hopkins and Seattle cancer centers. A video is attached below. It is not recommended if you have clinical pain from advanced PCa cancer in bones, but it looks as if it may stimulate response to immunotherapy treatment!!!!! and PARP inhibitor treatments!!!!

To Watch the Testosterone Replacement in the Treatment of Advanced Prostate Cancer - Sam Denmeade and Michael Schweizer Video
You can also Read the Full Video Transcript.
Click on the Link:

Link: High Testosterone
or Go To
https://www.urotoday.com/video-lectures/prostate-cancer-foundation-2019/video/mediaitem/1594-testosterone-replacement-in-the-treatment-of-advanced-prostate-cancer-sam-denmeade-and-michael-schweizer.html?utm_source=newsletter_7465&utm_medium=email&utm_campaign=prostate-cancer-daily

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Skip Milk? Opinions vary on its benefits

RVA - Us Too Warriors:

See below milk may increase hip fractures in taller adults

To Read the Article - Click on the Link:

Link: Milk
or Go To
https://www.mdlinx.com/dentistry/top-medical-news/article/2020/02/13/7608224/

For a PDF Verision - Click the Link

Link: Milk
or Go To
http://rvaprostatecancersupport.org/PDF/2 14 20 Skip milk.pdf

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Blood Thinners

RVA - Us Too Warriors:

Many men take blood thinners to reduce blood pressure

Many men take blood thinners to reduce blood pressure - Too much thinning can lead to bleeding problems so the attached website is to help you in managing this situation:

To Read the Article - Click on the Link:

Link: Blood Thinners
or Go To
https://www.consumerlab.com/answers/supplement-interactions-with-apixaban-Eliquis/eliquis-supplement-interactions/?j=1252737&sfmc_sub=17796464&l=529_HTML&u=17421062&mid=7276525&jb=121&utm_medium=email&utm_source=exacttarget&utm_campaign=newsletter&utm_term=&utm_content=B12_expired_de_send

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Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents

RVA - Us Too Warriors:

I hope you can find your way through the maze to find the plants that fight your cancer.

Abstract
Prostate cancer is a heterogeneous disease, the second deadliest malignancy in men and the most commonly diagnosed cancer among men. Traditional plants have been applied to handle various diseases and to develop new drugs. Medicinal plants are potential sources of natural bioactive compounds that include alkaloids, phenolic compounds, terpenes, and steroids. Many of these naturally-occurring bioactive constituents possess promising chemopreventive properties. In this sense, the aim of the present review is to provide a detailed overview of the role of plant-derived phytochemicals in prostate cancers, including the contribution of plant extracts and its corresponding isolated compounds.

To Read the Article - Click on the Link:

Link: Phytochemicals
or Go To
http://rvaprostatecancersupport.org/PDF/2 10 20 PCa-Flavanoids from numerous Plants to fight PCa.pdf

*****

ASCO 2019: ENZAMET, Overall Survival Results
of a Phase III Randomized Trial of Standard-of-care Therapy with or
without Enzalutamide for mHSPC, an ANZUP-led International Cooperative Group Trial

RVA - Us Too Warriors:
The 70 to 80% loss of QOL in both groups as shown by graphs at the end of this abstract is shocking to me. It is the reason I have avoided ADT like the plague. I am finding I am increasing my work out weights slowly at YMCA and at home. My Antioxidant and anti-inflammatories are designed to slow my aging as well as slow my cancer. I hope you can find your own happy life style to follow.

Barcelona, Spain (UroToday.com) At 2019 ASCO meeting, Davis and colleagues previously reported that treatment with enzalutamide rather than an older non-steroidal anti-androgen (bicalutamide, nilutamide, or flutamide), resulted in longer overall survival when added to standard first-line treatment, with or without concurrent early docetaxel, in mHSPC (HR 0.67, 95% CI 0.52 to 0.86, p = 0.002).1 Additionally, enzalutamide also leads to longer progression free survival (HR 0.40, 95% CI 0.33-0.49). At the ESMO 2019 prostate cancer session, Dr. Stockler and colleagues from the ENZAMET consortium reported results of the health-related quality of life data.

To Read the Article - Click on the Link:

Link: Enzamet
or Go To
https://www.urotoday.com/conference-highlights/asco-2019-annual-meeting/asco-2019-prostate-cancer/112971-asco-2019-overall-survival-results-of-a-phase-iii-randomized-trial-of-standard-of-care-therapy-with-or-without-enzalutamide-for-mhspc-enzamet-an-anzup-led-international-cooperative-group-trial.html

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Systemic Alkalinisation Delays Prostate Cancer Cell Progression in TRAMP mice

RVA - Us Too Warriors:

IS Alkaline water Good for Bone density, Preventing dental decay, dry mouth from chemo therapy, and slowing Prostate cancer???.

Abstract
The microenvironment of solid tumours is extremely acidic and this condition arises since the precancerous stage. This acidic milieu could therefore provide a useful target for both prophylactic and therapeutic approaches. In TRAMP transgenic mice, an in vivo model of prostate adenocarcinoma (AC), oral administration of alkaline water was devoid of unwanted side effects, and when started from an early age was as effective as NaHCO3 in significantly delaying tumour progression, while when started when prostate tumours were already present, a nonstatistically significant trend in the same direction was detected. These findings indicate that the use of alkalinizing drugs should be considered for chemoprevention and, in association with standard chemotherapy, for treatment of human prostate AC.

To Read the Article - Click on the Link:

Link: Alkalinisation
or Go To
http://rvaprostatecancersupport.org/PDF/2 9 20 Astigiano-2017-Systemic-alkalinisation-delays-pros.pdf

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Quercetin Targets hnRNPA1 to Overcome Enzalutamide Resistance in Prostate Cancer Cells

RVA - Us Too Warriors:

I read that this may keep Taxane from failing too. Dose recommended of quercetin is 1000 to 3000 mg /day.

Abstract
Prostate cancer remains dependent on androgen receptor signaling even after castration. Aberrant androgen receptor signaling in castration-resistant prostate cancer is mediated by mechanisms such as alterations in the androgen receptor and activation of interacting signaling pathways. Clinical evidence confirms that resistance to the next-generation antiandrogen, enzalutamide, may be mediated to a large extent by alternative splicing of the androgen receptor to generate constitutively active splice variants such as AR-V7. The splice variants AR-V7 and ARv567es have been implicated in the resistance to not only enzalutamide, but also to abiraterone and other conventional therapeutics such as taxanes. Numerous studies, including ours, suggest that splicing factors such as hnRNPA1 promote the generation of AR-V7, thus contributing to enzalutamide resistance in prostate cancer cells. In the present study, we discovered that quercetin, a naturally occurring polyphenolic compound, reduces the expression of hnRNPA1, and consequently, that of AR-V7. The suppression of AR-V7 by quercetin resensitizes enzalutamide-resistant prostate cancer cells to treatment with enzalutamide. Our results indicate that quercetin downregulates hnRNPA1 expression, downregulates the expression of AR-V7, antagonizes androgen receptor signaling, and resensitizes enzalutamide-resistant prostate cancer cells to enzalutamide treatment in vivo in mouse xenografts. These findings demonstrate that suppressing the alternative splicing of the androgen receptor may have important implications in overcoming the resistance to next-generation antiandrogen therapy. Mol Cancer Ther; 16(12); 2770–9. ©2017 AACR.
Best Peter

To Read the Article - Click on the Link:

Link: Quercetin
or Go To
https://mct.aacrjournals.org/content/16/12/2770

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Discovery of new T-cell raises prospect of ‘universal’ cancer therapy

RVA - Us Too Warriors:

I hope this proves true and they start testing it on Patients by the end of the year as they Hope?!!!!

Researchers at Cardiff University have discovered a new type of killer T-cell that offers hope of a “one-size-fits-all” cancer therapy.

Best Peter

To Read the Article - Click on the Link:

Link: Discovery
or Go To
https://www.cardiff.ac.uk/news/view/1749599-discovery-of-new-t-cell-raises-prospect-of-universal-cancer-therapy

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Luteolin

RVA - Us Too Warriors:

Luteolin inhibits blood vessel growth to slow PCa. See attachment below Below.

Best Peter

To Read the Article - Click on the Link:

Link: Luteolin
or Go To
http://rvaprostatecancersupport.org/PDF/2 1 20 PCa-Luteolin.pdf

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Oriole Clinic trial

RVA - Us Too Warriors:

I tried to sign up for this JH's Oriole Clinic trial 2017 when my psa was growing rapidly, but I was at the tail end of the trial when they were winding down and they could not fit me in. The results looks very promising as a way to make SBRT treatment to Oligo Mets more effective . See Below

Best Peter

To Read the Article - Click on the Link:

Link: Oriole
or Go To
https://grandroundsinurology.com/pca-commentary-volume-142-january-2020/

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PSA Doubling Time and Absolute PSA Predict Metastasis-free Survival

RVA - Us Too Warriors:

PSA Doubling Time and Absolute PSA Predict Metastasis-free Survival in Men With Biochemically Recurrent Prostate Cancer after Radical Prostatectomy - Beyond the Abstract
My cancer metastasized between my 16th and 19th years after BCR. During that time My PSA went from 2.2 to 12 and PSA doubling time went from 18 months at the 16th year to 5 months in the 19th year. I wish I had started my present casodex/metformin/avodart(dutasteride)/doxycycline treatment when my PSA started to double faster after it went over 1.3 which had a doubling time of 3 to 4 years. I start the caosodex/etc treatment as soon as the Axumin pet scan showed multiple lymph nodes in my pelvis and in my right hip socket femur. Two MRI scans during this 3 year fast rise in PSA did not show any mets because MRI is not good at seeing lymph node mets and MRI did not extend down to my hip - I did not know these limitations when had 2 MRIs as my PSA increased faster. I did have the MRI extended to cover my hip and the hip bone met showed up.

If possible you should add treatments to stop mets if your PSA is rising fast (a short doubling time the abstract below indicates that a doubling time of less than 7.5 months for is point at which mets will occur. I would suggest 9 months to give you time to get the treatment started. Read the following abstract to get more information. I am fortunate that my METs have respond for two years now with PSA < 0.025 - I do not know if I have no mets now because I can not image them as the PSA is to low to detect

Best Peter

To Read the Article - Click on the Link:

Link: PSA Doubling Time
or Go To
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/118729-psa-doubling-time-and-absolute-psa-predict-metastasis-free-survival-in-men-with-biochemically-recurrent-prostate-cancer-after-radical-prostatectomy-beyond-the-abstract.html

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The Aberrant Hedgehog (Hh) Signaling Induced by Mutations

RVA - Us Too Warriors:

This growth SHH pathway is slowed down by such supplements as Vitamin D3, Green tea, Curcumin, Berberine, Apigenin, resveratrol, quercetin. All of which I have been using - some for many years. Swanson is a Good source.

The aberrant Hedgehog (Hh) signaling induced by mutations or overexpression of the signaling mediators has been implicated in cancer, associated with processes including inflammation, tumor cell growth, invasion, and metastasis, as well as cancer stemness. Small molecules targeting the regulatory components of the Hh signaling pathway, especially Smoothened (Smo), have been developed for the treatment of cancer. However, acquired resistance to a Smo inhibitor vismodegib observed in clinical trials suggests that other Hh signaling components need to be explored as potential anticancer targets. Natural and dietary compounds provide a resource for the development of potent agents affecting intracellular signaling cascades, and numerous studies have been conducted to evaluate the efficacy of natural products in targeting the Hh signaling pathway. In this review, we summarize the role of Hh signaling in tumorigenesis, discuss results from recent studies investigating the effect of natural products and dietary components on Hh signaling in cancer, and provide insight on novel small molecules as potential Hh signaling inhibitors.

Best Peter

To Read the Article - Click on the Link:

Link: Aberrant Hedgehog
or Go To
http://rvaprostatecancersupport.org/PDF/1 27 20 PCa-Hedgehog Signaling in Cancer by Natural and diet.pdf

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CRPC produced by ADT treatment of Hormone Sensitive Cancers

RVA - Us Too Warriors:

The attached papers indicated CRPC produced by ADT treatment of hormone sensitive cancers makes the cancer grow by increasing prolactin which can be blocked by drugs that block prolactin, Cabergoline (dostinex) or bromocriptine, to possible put the CRPC cancer in remission.
Best Peter

To Read the Articles - Click on the Links:

Link: Clioquinol
or Go To
http://rvaprostatecancersupport.org/PDF/1 26 20 PCa-Clioquinol.pdf

Link: PCa-prolactin
or Go To
http://rvaprostatecancersupport.org/PDF/1 26 20 PCa-prolactin.pdf

Link: PCa-Termination
or Go To
http://rvaprostatecancersupport.org/PDF/1 26 20 PCa-Termination of Untreatable Androgen-independent Prostate cured with Cabergoline.pdf

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Berberine

RVA - Us Too Warriors:

Consider Berberine from Swanson if you are not already using about 3 pills per day which I have recommended for several years.

Berberine Inhibits the Metastatic Ability of Prostate Cancer Cells by Suppressing Epithelial-to-Mesenchymal Transition (EMT)-Associated Genes with Predictive and Prognostic Relevance.

Best Peter

To Read the Study - Click on the Link:

Link: Berberine
or Go To
http://rvaprostatecancersupport.org/PDF/1 22 20 PCa-Berberine.pdf

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Treatment Gene Testing

RVA - Us Too Warriors:

I made these comments at the meeting to help men determine at what stages in their treatment gene testing is valuable in planning your treatment . These are my comments

The Attached Video was shown at our Jan 16, 2020 meeting.
Genetics in Prostate Cancer: Identification of Inherited Prostate Cancer Risk –

Summary:
Leonard G. Gomella, MD, FACS, reviews basic concepts of genetics and genomics, the role of genetics and genomics testing in the management of prostate cancer, and methods of genomic tissue testing. He also emphasizes the difference between recreational genomics and genetic testing supervised and mentored by healthcare professionals.

Best Peter

To Read Peter's Comments - Click on the Link:

Link: Treatment Gene Testing
or Go To
http://rvaprostatecancersupport.org/PDF/1 18 20 Notes.pdf

To Watch “Genetics in Prostate Cancer: Identification of Inherited Prostate Cancer Risk” Video
Click on the Link:

Link: Genetics
or Go To
https://grandroundsinurology.com/genetics-in-prostate-cancer-identification-of-inherited-prostate-cancer-risk-2/

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Diet and Exercise

RVA - Us Too Warriors:

In winter it is important to focus on Diet and Exercise because it is harder to get outside and vegetables are needed even more but become less available.

Best Peter

To Read the Prostatepedia Article - Click on the Link:

Link: Diet and Exercise
or Go To
http://rvaprostatecancersupport.org/PDF/1 15 20 ProstatepediaDietExercise.pdf

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Imaging Bone (Flare) Responses

RVA - Us Too Warriors:

Imaging Bone (Flare) Responses in Advanced Prostate Cancer Presentation - Anwar Padhani

The website video below is intriguing in showing live and dead cells produced in the sequence of treatments for advanced bone Pcancers and showing cells not responding which may be biopsied to determine mutations which may be treated by a different effective therapy!!

Best Peter

To Read more and see the Video - Click on the Link:

Link: (Flare)
or Go To
https://www.urotoday.com/center-of-excellence/imaging-center/video-lectures/video/mediaitem/1450-players-brightcove-net2019-09-06-14-43-16.html?utm_source=newsletter_7296

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Melatonin

RVA - Us Too Warriors:

Melatonin May Increase Anticancer Potential of Pleiotropic Drugs

Abstract:
Melatonin (N-acetyl-5-methoxytryptamine) is not only a pineal hormone, but also an ubiquitary molecule present in plants and part of our diet. Numerous preclinical and some clinical reports pointed to its multiple beneficial effects including oncostatic properties, and as such, it has become one of the most aspiring goals in cancer prevention/therapy. A link between cancer and inflammation and/or metabolic disorders has been well established and the therapy of these conditions with so-called pleiotropic drugs, which include non-steroidal anti-inflammatory drugs, statins and peroral antidiabetics, modulates a cancer risk too. Adjuvant therapy with melatonin may improve the oncostatic potential of these drugs. Results from preclinical studies are limited though support this hypothesis, which, however, remains to be verified by further research

Best Peter

Also:
RVA Us Too Warriors, Most of my many antioxidant supplement polyphenols are designed to inhibit IL-6 stimulation of NFkb, But melatonin which I take at very high dose of 40 mg per night is very good at doing this and keeps ARV-7 from making Anti-Androgen therapies like Xtandi, casodex etc from failing from CRPC.
and
Melatonin Inhibits Androgen Receptor Splice Variant-7 (AR-V7)-Induced Nuclear Factor-Kappa B (NF-κB) Activation and NF-κB Activator-Induced AR-V7 Expression in Prostate Cancer Cells: Potential Implications for the Use of Melatonin in Castration-Resistant Prostate Cancer (CRPC) Therapy.

To Read more on these subjects - Click on the Links:

Link: IL-6 Stimulation
or Go To
http://rvaprostatecancersupport.org/PDF/2 8 20 PCa-Melatonin differentiates PCa and slows growth.pdf

Link: Variant-7 (AR-V7)
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485954/#__ffn_sectitle

Link: Anticancer Potential
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320927/

and
Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis

Abstract:
There is highly credible evidence that melatonin mitigates cancer at the initiation, progression and metastasis phases. In many cases, the molecular mechanisms underpinning these inhibitory actions have been proposed. What is rather perplexing, however, is the large number of processes by which melatonin reportedly restrains cancer development and growth. These diverse actions suggest that what is being observed are merely epiphenomena of an underlying more fundamental action of melatonin that remains to be disclosed. Some of the arresting actions of melatonin on cancer are clearly membrane receptor-mediated while others are membrane receptor-independent and involve direct intracellular actions of this ubiquitously-distributed molecule. While the emphasis of melatonin/cancer research has been on the role of the indoleamine in restraining breast cancer, this is changing quickly with many cancer types having been shown to be susceptible to inhibition by melatonin. There are several facets of this research which could have immediate applications at the clinical level. Many studies have shown that melatonin’s co-administration improves the sensitivity of cancers to inhibition by conventional drugs. Even more important are the findings that melatonin renders cancers previously totally resistant to treatment sensitive to these same therapies. Melatonin also inhibits molecular processes associated with metastasis by limiting the entrance of cancer cells into the vascular system and preventing them from establishing secondary growths at distant sites. This is of particular importance since cancer metastasis often significantly contributes to death of the patient. Another area that deserves additional consideration is related to the capacity of melatonin in reducing the toxic consequences of anti-cancer drugs while increasing their efficacy. Although this information has been available for more than a decade, it has not been adequately exploited at the clinical level. Even if the only beneficial actions of melatonin in cancer patients are its ability to attenuate acute and long-term drug toxicity, melatonin should be used to improve the physical wellbeing of the patients. The experimental findings, however, suggest that the advantages of using melatonin as a co-treatment with conventional cancer therapies would far exceed improvements in the wellbeing of the patients.

To Read more on this subject - Click on the Links:

Link: Full Service
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412427/

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Melanoma Cancer

RVA - Us Too Warriors:

A while back I sent out an email that suggested that men with prostate cancer were more likely to develop melanoma cancer. I developed two melanomas over the last 3 years-both at stage one and barely stage 2 deep in the skin. I am hoping my high vitamin D3 and Milk Thistle (Silibinin) keep them at 1 and 2 mm thickness depths that I experienced. My Brother, tried the Milk thistle (silibinin) and got a drop in his PSA. The benefits of these supplements for PCa and melanoma are discussed in the attachments.

Best Peter

To Read more on this subject - Click on the Links:

Link: Silibinin
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466371/

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Suppression of Taxanes Cytotoxicity

RVA - Us Too Warriors:

Suppression of Taxanes Cytotoxicity by Citrus Flavonoid Hesperetin in PPC-1 Human Prostate Cancer Cells

KATRIN SAK1⇑, HELEN LUST1, MARJU KASE2,3, MARIKA SAAR4 and JANA JAAL1,2

1Clinic of Hematology and Oncology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia
2Department of Radiotherapy and Oncological Therapy, Tartu University Hospital, Tartu, Estonia
3East-Tallinn Central Hospital, Tartu, Estonia
4Pharmacy, Tartu University Hospital, Tartu, Estonia

Correspondence to: Katrin Sak, Clinic of Hematology and Oncology, University of Tartu, L. Puusepa 8, 51014 Tartu, Estonia. Tel: +372 53341381, e-mail: katrin.sak{at}ut.ee

Abstract

Background/Aim: More than half of prostate cancer patients use, in addition to conventional therapies, some kind of complementary medicine, including flavonoid-rich products. However, knowledge about the co-effects of flavonoids with cytotoxic chemotherapies is still rather poor. Therefore, this study was undertaken to assess the cytotoxic activity of flavonoids and their interactions with taxanes in human advanced prostate cancer cells. Materials and Methods: Cytotoxicity of different flavonoids and their effects on the efficacy of docetaxel and cabazitaxel were studied in the human metastatic prostate cancer cell line PPC-1, using MTT colorimetric assay. Results: Both taxanes suppressed the viability of PPC-1 cells with IC50 values in the nanomolar range. Tested flavonoids exerted cytotoxic activity only at high micromolar concentrations or revealed no remarkable effect on cell survival. Simultaneous treatment of cells with taxanes and flavonoids baicalein, chrysin, luteolin, fisetin, quercetin, genistein or daidzein did not lead to any change in chemotherapy-induced cytotoxicity. However, simultaneous exposure of cells to hesperetin and taxanes resulted in 9.8- and 13.1-fold reduction in cytotoxicity of docetaxel and cabazitaxel, respectively. Conclusion: Flavonoid hesperetin remarkably suppressed the cytotoxic efficacy of taxanes in prostate cancer cells. Therefore, caution is required from prostate cancer patients who take hesperetin-containing oral supplements.

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Grapefruit

RVA - Us Too Warriors:

Us too Warriors, At the PotLUCK dinner, I mentioned I was limiting my grapefruit consumption to 1/2 grapefruit for breakfast. A glass of juice seems to be more likely to be a problem than half grapefruit for a toxic build up of a drug in the body by interfering with an enzyme (CYP3A4) that metabolize drugs. The paper attached gives known drugs that interact with grapefruit and its juice. I find several of the drugs I take have their metabolism inhibited by Grapefruit so I am limiting my grapefruit to 1/2 a day and lowering these drugs slightly and doing blood tests to keep them at the right levels. A benefit of slow metabolism of expensive Chemotherapies is that less drug is needed for effect so thousands of dollars a month may be saved.

A limited amount of grapefruit can have benefits of lowering sugar in your blood and making insulin more effective. My A1c this last 3 months was the lowest it has ever been at 4.9 after the eating limited grapefruit, and taking berberine and Metformin. My Glucose is 84 in the blood test another low. It is important that your blood sugar not go too low (<70) to produce hypoglycemia and potential toxic shock from too low blood sugar.

Best Peter

To Read more on this subject - Click on the Link:

Link: Grapefruit
or Go To
http://rvaprostatecancersupport.org/PDF/12 14 19 PCa-Grapefruit and Juice.pdf

Link: Grapefruit Enzyme
or Go To
https://en.wikipedia.org/wiki/CYP3A4#Function

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Supplements

RVA - Us Too Warriors:

I have often been asked what supplements I take to keep my cancer under control. I have given many talks over the years about what I have learned as I add something new . But this is the first time, I have put it all together. The reason was Dr.Snuffy Meyers asked me to inform him of my efforts. He said I will be keeping him busy as he goes over it.

Best Peter

To Read more on this subject - Click on the Link:

Link: Supplements
or Go To
http://rvaprostatecancersupport.org/PDF/12 11 19 Moon Dec 2019 last.pdf

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Peanut Agglutinin

RVA - Us Too Warriors:

Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galectin-3 to promote metastasis by interaction with cancer-associated MUC1.

Peanut agglutinin (PNA), which accounts for ~0.15% of the weight of the common peanut, is a carbohydrate-binding protein that binds the oncofoetal Thomsen-Friedenreich (TF) disaccharide (galactoseβ1,3N-acetylgalactosamineα-) that is overexpressed by ~90% of human cancers.

Best Peter

To Read more on this subject - Click on the Link:

Link: Peanut Agglutinin
or Go To
https://www.ncbi.nlm.nih.gov/pubmed/25326505#

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Onvansertib/Abiraterone Stabilizes PSA in 75 Percent of Patients With mCRPC
RVA Us Too Warriors:

The combination of onvansertib (PCM-075) with abiraterone acetate (Zytiga) decreased the prostate-specific antigen (PSA) levels in most of the evaluable patients treated in a phase II study (NCT03414034), which used the combination in adult patients with metastatic castration-resistance prostate cancer (mCRPC), according to a press release from onvansertib developer, Trovagene, Inc.1

Best Peter

To Read more on this subject - Click on the Link:

Link: Onvansertib/Abiraterone
or Go To
https://www.targetedonc.com/news/onvansertibabiraterone-stabilizes-psa-in-75-percent-of-patients-with-mcrpc

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Highlights of Natural Products in Prostate Cancer Drug Discovery
RVA Us Too Warriors:

Where does it all come from:

1. Introduction - The remarkable impact of natural products (NPs) in the quest for new agents and new directions in medicinal discovery is well established. The exploration of Nature as a source of novel active agents that may serve as leads and scaffolds for drugs targeting a myriad of diseases and the use of synthetic organic chemistry to modify them have been a driving force for drug discovery.

2. Natural products and cancer - Over the course of millennia, natural compounds have evolved into specific scaffolds that interact with cellular macromolecules (Clardy & Walsh, 2004). Such scaffolds can be used as templates and fine-tuned by medicinal chemists to produce novel compounds with therapeutic applications.

Best Peter

To Read more on this subject - Click on the Link:

Link: Natural Products
or Go To
http://rvaprostatecancersupport.org/PDF/11 26 19 PCa-Natural Products in PCa related Pten neagative and othe conditions.pdf

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Statin Use
RVA Us Too Warriors:

Statin Use is associated with lower risk of PTEN-null and lethal prostate cancer.
Best Peter

To Read more on this subject - Click on the Link:

Link: Statin Use
or Go To
http://rvaprostatecancersupport.org/PDF/11 25 19 10.1158_1078-0432.CCR-19-2853.pdf

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Rural Areas
RVA Us Too Warriors:

If you have friends in this fight in remote or rural areas please forward this email to them so they can get access to information to help them make good decisions.
Best Peter

To Read more on this subject - Click on the Link:

Link: Rural Areas
or Go To
https://myemail.constantcontact.com/National-Rural-Health-Day.html?soid=1127669815285&aid=VlDCMKTaPL8

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Enzalutamide
RVA Us Too Warriors:

My Brother has responded well to enzalutamide for over four years and I have used Casodex going on 2 years (Cancer considered undetectable because PSA<0.1), both are blockers of the Androgen receptor. We both have germline mutation of TMPRSS2-ERG. The attached paper predicts we should have a good response with this mutation from AR Blockers (50% of men have this mutation) that we have experienced.
All Best,
Peter

To Read more on this subject - Click on the Link:

Link: Enzalutamide
or Go To
http://rvaprostatecancersupport.org/PDF/11 16 19 PCa-TMPRSS2-ERG fusions confer efficacy of enzalutamide because of its higher hormone sensitive cancer.pdf

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Dutasteride
RVA Us Too Warriors:

The abstract below shows the benefit of using Dutasteride(avodart) after biochemical failure in a two year study to prevent cancer progression.
It worked to slow my progression for 15 years from 2000 to 2014.
All Best,
Peter

To Read more on Avodart - Click on the Link:

Link: Avodart
or Go To
https://www.europeanurology.com/article/S0302-2838(12)01337-1/fulltext
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Cheese
RVA Us Too Warriors:

I was a voracious cheese eater and milk drinker until I got PCa. Now I avoid cheese and milk like the plague it is and the calcium supplements too. Read below

To Read more on Milk & Cheese - Click on the Link:

Link: Cheese
or Go To
https://www.newsmax.com/health/health-news/cheese-prostate-cancer-risk/2019/11/04/id/940038/?ns_mail_uid=c706a56c-a267-4741-b22b-100e337a8c5f&ns_mail_job=DM65508_11042019&s=acs&dkt_nbr=0101247aif0w
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Bipolar Androgen Therapy (BAT)
RVA Us Too Warriors:

This may well be my next choice for treatment when my present treatment fails as I expect in the next three years- by that time I will have a good 5 year run on my present casodex treatment. I am very excited about this treatment. I think you will be too.

See Slides Attached.
All the best Peter

To Read more on BAT:

Link: BAT
or Go To
http://rvaprostatecancersupport.org/PDF/10 23 19 PCa-Samuel Denmeade, MD John HopKins U Bipolar Androgen Therapy for Asymtomatic Advanced PCa (Cycling ADT with High Testoeterone injections to Make CRPC respond again to Anti Androgens).pdf

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HIF-1 Genes/Proteins pathway
RVA Us Too Warriors:

High levels of HIF-1 genes/proteins pathway makes PCa recur. Read and see attachments following about how to fight it. The natural inhibitors of Heat Shock Protein 90 that I talked about at our June 2019 meeting are easiest way to apply this knowledge now, until some expensive drug is FDA proves sometime in the future. Many flavonoids were found to be inhibitors of phosphatidylinositol 3-kinase/AKT signaling. Chrysin inhibited AKT activation. Thus, it is conceivable that chrysin may also inhibit HIF-1a via AKT signaling. It was reported that flavonoids or related compounds, such as apigenin (28, 46), resveratrol (47), and ()-epigallocatechin-3-gallate (48), inhibited expression of HIF-1a through multiple pathways, including protein synthesis and protein degradation.

Other natural inhibitors are berberine, and quercetin and Chrysin!!! Many of these Block the heat Shock Protein 90 from promoting HIF-1 which I talked about in June 2019 as a way to fight your cancer by blocking PIK3/AKT/ mTOR cancer pathways which is prominent growth by many PCa gene mutations like BRACA and Pten mutations.

PARP inhibitor drugs are now available to block PIK3/AKT/ mTOR cancer pathways are used BRACA and Pten mutated PCa among others but they work for relative short times ~1 < 2 years. Fruit enriched diet will contain many of the natural inhibitors which can be fortified with supplements from Swanson etc.

To Read more on this subject:

Link 1 - Hypoxia inducible factor pathway inhibitors
Link 2 - Natural Product-Based Inhibitors
Link: Hypoxia inducible factor pathway inhibitors
or Go To
http://rvaprostatecancersupport.org/PDF/10 18 19 PCa-HIF-1 Hypoxia inducible factor pathway inhibitors as anticancer therapeutics.pdf

Link: Natural Product-Based Inhibitors
or Go To
http://rvaprostatecancersupport.org/PDF/10 18 19 PCa-Natural Product-Based Inhibitors of Hypoxia-Inducible Factor-1 to prevent PCa recurrence.pdf

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Advanced Cancer with Castration Resistance
RVA Us Too Warriors:

In advanced cancer with castration resistance, Xtandi and Zytiga fail even on ADT because the Androgen receptor is Shortened (AR-V7) so that it is always active causing the cancer to grow even when testosterone is extremely low. The Clinical trial below tests Niclosamide At UCLA to overcome this problem. And at the end of the trial are attached two papers attached describing the blood tests for your information- One is test is from John Hopkins.

To Read more on this subject:

Link: Resistance
or Go To
http://rvaprostatecancersupport.org/PDF/10 16 19 PCa-AR-V7 and its Clinical Correlates in Metastatic Castration-resistant PCa.pdf

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PCa-Immunotherapies for Prostate-5

RVA Warriors:

Past Current and Future for PCa-Immunotherapies for Prostate-5

To Read more on this subject:

Link: PCa-Immunotherapies
or Go To
http://rvaprostatecancersupport.org/PDF/10 9 19 PCa-Immunotherapies for Prostate-5.pdf

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Association between post-diagnostic use of cholera vaccine and risk of death in prostate cancer patients

RVA Warriors:

Guys, This looks promising below? - Peter Moon PhD

To Read more on this subject:

Link: Promising
or Go To
http://rvaprostatecancersupport.org/PDF/10 9 19 PCa-Vaccine post-diagnostic use of cholera vaccines41467-018-04814-4.pdf

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Calculator

RVA Warriors:

The Website Calculator below shows the chances of PCa for men not diagnosed yet or it can be used to see what your chancers were when you were diagnosed based on your information then. My information at age 54 years old when diagnosed suggested I had a 9% chance of aggressive cancer and a 11% of not aggressive cancer. This is a high ratio of aggressive cancer which I turn out to have -- Peter Moon PhD

To go to the Calculator use our Link:

Link: Calculator
or Go To
http://www.prostatecancer-riskcalculator.com/seven-prostate-cancer-risk-calculators

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Genomic Drivers of Poor Prognosis

US Too Warriors:

The paper below is helpful if you have progressed to advanced cancers - It will help you to navigate what treatments may still work. We have men in our group who are making the decision on their next treatments after failure on Xtandi or Zytiga. Please keep them in your thoughts and prays.
Enjoy the gift of this beautiful Day -- Peter Moon PhD

To read more on this subject:

Link: Drivers
or Go To
http://rvaprostatecancersupport.org/PDF/10 4 19 j.eururo.2019.03.020.pdf

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Gene Mutations

US Too Warriors:

I have been trying to send you information on gene Mutations that may help you see what treatment or supplements could be better to treat your cancer as influenced by your genes. I have done this for myself and found that what I had been doing for my gene mutations seems to be the right choice.

I downloaded my "raw gene data from a 23&Me cheek swab to promethease.com and in about 15 minutes they (Promethease) sent me back a report.

The following website tells you how to do this==>https://www.xcode.life/23andme-raw-data/promethease-report-health-alternative-read/

Now this website explains how to do this and how to get simplified reports that are broken down in to different disease problems that they will analyze for you for a fee. I did not know of this added analysis - so I would put into the input search box what I wanted know like "prostate cancer, PCa Mutations like: TMPRSS2-erg, P10. P53, MDM2, Brca1,2, ATM etc, Alzheimer's and AMD, Heart disease and more.

The Bolded entries showed I had bad actor genes in those area's. I was aware of these concern areas from family history but it has been helpful to allow me to be proactive. The cost of the raw gene analysis by companies like 23&Me cost about $99 and $10 promethease raw data analysis in past it may be free for next 2 Months?? ( I do not know the cost for individual problem analysis). You can download their report to your computer and search the results at your leisure.

If you are so moved check the website to see how to do this for yourself if you like???

I hope this helps, Best Peter

To go to the Website use our link:
Link: Promethease
or Go To
https://www.xcode.life/23andme-raw-data/promethease-report-health-alternative-read

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Natural Inhibitors

US Too Warriors:

Read the below links to see how you might benefit from natural inhibitors of Mutations and from having your mutations analyzed.

First prostate cancer therapy to target genes delays cancer progression
Link: Target
or Go To
https://medicalxpress.com/news/2019-09-prostate-cancer-therapy-genes.html

In the Suvarna paper are natural agents that block the PI3K-AKT-mTOR pathways which is the promotes cancer if you have a mutated Pten gene.

In table 1 are listed 29 natural agents. I take 16 of the agents (most at 3 pills a day except for green tea that I take 12 pills per day and Curcumin at 15 pills per day and emodin (also called Fo-Ti at 6 pills per day) . In fact when I saw Dr. Meyers in 2008, he did not like emodin, so I doubled it from 3 to 6 pills. Dr. Meyers knew it was in class poisons from his Pharmaceutical background - I thought I need a poison to kill the cancer - this Suvarna paper supports this.

PARP inhibitor drugs like Olaparib work on PI3K pathway for medium of 6 to 12 months before progression and have more side effects than taking these supplements will and you do not need a prescription -order online from swanson or LEF.org - some may be cheaper if order on Amazon or during a sale in November to end of January from LEF if you join you can save more .

The first Paper gives supplement that make P53, the Big Cohuna of anticancer genes, work better and down play the damaging effect of Bad Actor, MDM2, the second paper shows I a diagram of the pathway of PI3K and MDM2 can screw up this making cancer worse too.

To read more on this subject:

Link: Natural Inhibitors
or Go To
http://rvaprostatecancersupport.org/PDF/10 1 19 PCa-Natural products targeting the p53-MDM2.pdf

Link: PI3K and MDM2
or Go To
http://rvaprostatecancersupport.org/PDF/10 1 19 Suvarna-2017-Phytochemicals-and-pik-inhibitors-i.pdf

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Precision Medicine

US Too Warriors:

The attached paper is a follow up to my talk last night on Purpose of my Talk to get you to "Learning your Mutations in Your cancer so you can find a treatment/doctor who can/will treat you with a drug targeted at your mutation = Precision Medicine.!!!!
Not to give you the standard of Care that is 30 years out of date.

To read more on this subject:

Link: Precision Medicine
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483502/

Link: Detection
or Go To
http://rvaprostatecancersupport.org/PDF/ 9 14 19 PP-Gene Analysis IS Imperative Us Too Sept19, 2019 PDF.pdf

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Gene Analysis

US Too Warriors:

I learned a lot about Prostate cancer and its mutation and how we can fight them in putting together this talk. It has helped me understand how or why I have been successful in beating back my cancer by what have done without knowing all the science for 25 years. I hope I can convey the ideas/research that I have found so you can do the same for yourself with your Doctors help! I hope you can come to learn how you can help yourself.
All the best, Peter
To read more on this subject:

Link: Gene Analysis
or Go To
http://rvaprostatecancersupport.org/PDF/9 14 19 PP-Gene Analysis IS Imperative Us Too Sept19, 2019 PDF.pdf

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Hot flashes

US Too Warriors:

Hot flashes are one of many side effects that may cause men to stop advanced Prostate cancer treatments.

For almost 2 years on Casodex I have had hardly any hot flashes But, recently, last two days, I have had 3 flashes

These foods triggered the last one - Coffee, Dark chocolate, ginger and avocado. Also, hot spices/spicy food like capsaicin from hot peppers and heat are triggers. Also alcohol can trigger hot flashes.

Peter

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Metformin

US Too Warriors:

If your blood sugars glucose are not low <76, You may benefit by taking Metformin to lower blood glucose. If low glucose is already low you may produce hypoglycemia by taking metformin that can make you blackout if you do not get sugar right away. My fasting blood glucose is between 86 and 93 it should be below 100. I take 3 pills of 500mg of metformin per day with no problem. I do not have diabetes. But papers suggest the metformin can add 10+ years to your life line

To read more on this subject:

Link: Metformin
or Go To
http://rvaprostatecancersupport.org/PDF/6 8 19 Metformin.pdf

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PARP

US Too Warriors:

I am taking the following natural inhibitors of PARP: Calcitriol ( only on pill/day 0.5mcg as more would make my blood too high in calcium - dangerous for the heart), Taurine, Nicotinamide. fisetin, quercetin.

I did not know these where PARP inhibitors until I looked up "natural inhibitors of PARP" for you. (So trying to help you I learn for myself) I was taking them because I had read other papers that indicated they could help in fighting PCa -but I do not know the mechanism any more if I ever did.

For example in small study of men with rising PSA, a Seattle oncologist gave it to the 8 men on the study and 7 of the 8 had a drop in PSA that was good enough for me so I have been taking it for about 12 years and getting my blood calcium checked.

Fisetin lowers the estrogen affect on my breast growth. Quercetin makes my Metformin and Bicalutamide treatment more effective according to a research paper etc. It makes me wonder if the reason they help my PSA is because the also inhibit my PARP among whatever else they do.

It makes me smile to think I may have fallen to good treatment to my cancer with my shotgun approach????

All the Best Peter

To read more on this subject:

Click on Our Link

Link: PARP
or Go To
http://rvaprostatecancersupport.org/PDF/8 29 19 PCa- PARP inhibitory and in vivo antidiabetogenic potencies of taurine.pdf

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Dutasteride

US Too Warriors:

Us Too Warriors, I started dutasteride when my PSA = 0.29 five years after surgery and it keep it below 1.0 for 14 years! This paper below discuss research confirming those result. Other papers show this treatment works if you start dutasteride at less than 1.0 until the PSA progresses beyond 1.0 then it can take off - this happened to me after 15 years.

This paper wants to start dutasteride while PSA<0.195 so that they do not trigger the use radiation therapy to prostate bed control the PCa. This work 65% of the time that PSA did not exceed 0.2 which is the definition of biochemical recurrence which for these doctors in Taiwan trigger them to perform radiation- which I have avoid for twenty years now.

All the Best Peter

To read more on this subject:

Click on Our Link

Link: Dutasteride
or Go To
https://www.ncbi.nlm.nih.gov/pubmed/31428576

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Dutasteride

US Too Warriors:

Dr Bilusic, I have attached a paper that seems to apply to my favorable response to dutasteride for 14 years after BCR 2000 t0 2014 from surgery 1994.

And My recent Gene analysis shows I have TMPRSS2-erg mutate cancer in my germ line. I also have had an excellent result after PSA climbed 2.1 to 12.2, final doubling time at 5 months and metastasis ( hip bone and lymph nodes occurred between Jan 2015 to Dec 2017). PSA dropped 99.9% from Dec 2017 to May 2019. July 2019 PSA is 0.015 on 5mg proscar, .5mg dutasteride, 150mg Bicalutamide and 1500 mg metformin per day plus polyphenols supplements.

I think this will be of interest in your clinic trial, Peter

To read more on this subject:

Click on Our Link

Link: Dutasteride
or Go To
http://rvaprostatecancersupport.org/PDF/8 19 19 Ateeq-2012-Role-of-dutasteride-in-pre-clinical.pdf

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Protein 300

US Too Warriors:

I went to a cancer seminar at VCU Massey cancer Institute several years ago to hear a researcher from Philadelphia show that CURCUMIN block Protein 300 (P300).This protein was described as producing PCa growth. It is one of the many reasons I take 15 Super Biocurcumin pills per day. But the following blog with abstract attached is going to keep me doing this forever combined with the information in the UVa Paper sent earlier

Blog Follows:"Binding sites for two AR coregulators p300 and Brd4 reside near the HULLK transcriptional start site (TSS), and inhibitors of these coregulators down regulated HULLK. (!!!!!!!!!! my addition Peter)

There are BRD4 inhibitors in clinical trials now--ZEN3694 is specifically for prostate cancer and in a combo trial with enzalutamide.... watching this one, and a few others... there is a dual inhibitor of BRD4 and p300 in process-- NEO2734:"

This is good news as away to improve your treatment by adding and increasing your Super Bio Curcumin form LEF.org or another good source.

All the best , Peter
To read more on this subject:

Click on Our Link

Link: Protein 300
or Go To
https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.7_suppl.62

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P53

US Too Warriors:

P53 is the mother of all Anticancer GENES- If it is Mutated You will have a very aggressive cancer - Blog below is one I have started following recently that has men who have been fighting in the trenches to battle their cancer that gives new insights from their experience to fight cancer. I have know for years that watercress was a good fighter of prostate cancer but I did not know the type of cancer it was designed to fight or how to go about getting & using it. This discussion helps me understand these points. I do not think I have this P53 Mutation but I will check further as it could develop. I know from My own gene analysis that I do have TMPRSS2-ERG mutation and I have found that what I am doing in my treatment (Casodex, Metformin and Avodart) is taylor made to particularly aim at this mutation - and explains why I have had such good result of dropping my PSA 99% and still falling as of my last PSA May 1st - Next one August 1 st.

All the Best/Stay Cool.
Peter

To read more on this subject:

Click on Our Link

Link: P53
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/141225644/p53-mutant-type-in-human-prostate-cancer-cells-determines-sensitivity-to-phenethyl-isothiocyanate-watercress-induced-growth-inhibition

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ADT

US Too Warriors:

These trials are very much thinking outside the box on PCa treatment. As many of you know I am not a fan of ADT,
"the standard systemic treatment of advanced PCa" . It is hard to find any treatment beside this as it is the FDA approved
way. MY reading is that ADT treatment drives many men to castration resistance cancer which goes on to chemotherapy and is
hard to beat. The paper below describes trials of alternating high dose testosterone with testosterone blockage which produce
good results in PSA lowering in some men as well as holiday form the side effects of ADT. I had avoid standard ADT treatment
with Lupron which has driven my Testosterone to super high levels on just Casodex, Metformin and Avodart. This not standard
treatment is hard to get and though I have enough prescriptions for another year I am going to have to see if my new Oncologist
will still follow my new path.
Peter

To read more on this subject:
Click on Our Link

Link: ADT
or Go To
http://rvaprostatecancersupport.org/PDF/7 14 19 Prostate Cancer News.pdf

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Berberine

US Too Warriors:

Read the benefits below of Berberine for men with higher A1c >5.7 levels pushing them towards type 2 Diabetes
which is bad for cancer, heart and kidneys among other problems. I have been using berberine ( Swanson) with
metformin along with my use of Casodex to lower my PSA to undetectable in spite of mets imaged by AXumin 18 months ago.
My A1c measured recently = 5.3. (See Surprising Supplement #2: Berberine on the link below)
Peter

To read more on this subject:
Click on Our Links

Link: Berberine
or Go To
https://www.precisionnutrition.com/surprising-supplements

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Honokiol

US Too Warriors:

I had been researching sleep aids for my wife when I came on magnolia extract for sleep which I remembered in the past
I had read it has anti Prostate cancer effects. I have attached a website discussing its benefits and a source I used to
buy magnolia extract for my wife and myself
Peter

To read more on this subject:
Click on Our Links

Link: Honokiol
or Go To
https://www.beatcancer.org/blog-posts/honokiol-extract-and-integrative-cancer-treatment

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Fenbendazole

US Too Warriors:

I had mentioned in the past meetings that the anti-worm medicine, Niclosamide, was effective in restoring Enzalutamide and Bicalutamide treatment effectiveness after PSA started to rise during treatment. Now another anti-worm medicine, Fenbendazole, is being used by patient self treatment with many types of advanced cancers including PCa -dropping the PSA to Undetectable to put the cancer in remission.

It seems very promising to me; I think the Sun is coming out for all of US.
This is the best news,
Peter

To read more on this subject:
Click on Our Links

Link: Fenbendazole
or Go To
https://www.cancertreatmentsresearch.com/fenbendazole/

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Berberine

US Too Warriors:
Read the benefits below of Berberine for men with higher A1c >5.7 levels pushing them towards type 2 Diabetes which is bad for cancer, heart and kidneys among other problems. I have been using berberine ( Swanson) with metformin along with my use of Casodex to lower my PSA to undetectable in spite of mets imaged by AXumin 18 months ago. My A1c measured recently = 5.3.

All the best for Celebration of our Declaration of Independence, Peter

To read more on this subject:
Click on Our Links

Link: Berberine
or Go To
http://rvaprostatecancersupport.org/PDF/7 4 19 Berberine.pdf

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Newsletter

US Too Warriors:
This newsletter below discusses many of the complementary supplements ( I use all but 1 in the discussion).
All the Best, Peter

To read more on this subject:
Click on Our Link

Link: Newsletter
or Go To
http://rvaprostatecancersupport.org/PDF/7 1 19 PCa-Blaylock report on complementary therapy.pdf

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When test “validation” raises questions about levels of validity

US Too Warriors:
This test (Prolaris test)may help decide difference between active surveillance versus primary/aggressive treatment for lower risk men.
All Best, Peter Ps. try to stay cool and Hydrated

To read more on this subject:
Click on Our Links

Link: Validity
or Go To
https://prostatecancerinfolink.net/2014/05/23/when-test-validation-raises-questions-about-levels-of-validity/

Link: Prolaris
or Go To
https://prolaris.com/

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Bicalutamide and Curcumin work well

US Too Warriors:
I want to let you know that I have been taking Super Bio Curcumin from LEF.org at 15 pills a day for number of years along with many more supplements that my research show are active against many of PCa growth pathways ( see 2nd paper attached). I think my shotgun approach to treatment has made my adjuvant treatment make my Casodex and metformin treatment work so well. To read more on this subject:
Click on Our Link

Link: Bicalutamide and Curcumin
or Go To
http://rvaprostatecancersupport.org/PDF/6 26 19 Pca-Bicalutamide Combination-of-curcumin-and-bicalut (1).pdf

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What you eat can be your medicine

US Too Warriors:
I hope you have learned by now that what you eat can be your medicine. I have recently read the seed of the avocado contains more good anticancer content then the soft part so I have been cooking my seeds in the microwave for about ten minutes so I can soften it up to make it chewable - it is an acquired taste that is manageable with tomato sauce dish of beans and celery-The first time this week. Also, The white pith of orange skin is good source of phyto anticancer content along with its obvious fiber content. I try to eat about half the orange peel which manageable if you eat some of orange with the peel. I have been doing this several years. My mother taught me the good part ( vitamins & minerals) of any fruit/vegetable was in the skin so i have always eat the skin of apples and potatoes etc
Let me know if you have any similar ideas??
All the best Peter

To read more on this subject:
Click on Our Link

Link: Food
or Go To
https://www.sciencedirect.com/science/article/pii/S2221169117308730
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Testosterone Recovery After Cessation of Androgen-Deprivation Therapy for Prostate Cancer

The Journal of Sexual Medicine

US Too Warriors:
This will discuss the recovery in men after ADT treatment.
All best peter

TAKE-HOME MESSAGE

The authors performed a prospective analysis of patients receiving androgen-deprivation therapy (ADT) and the return to baseline testosterone levels. Testosterone levels were measured at baseline and after cessation of ADT. The authors analyzed the testosterone return to castrate level, return to normal level, and return to baseline level. A total of 307 men were included in the study. After 2 years of ADT cessation, testosterone in 8% of men remained at the castrate level, the level returned to normal (>300 ng/dL) in 76%, and returned to baseline in 51%. Predictors of slow recovery included baseline testosterone <400 ng/dL, ADT duration >6 months, and age >65.

ADT can be the cause of substantial undesirable side effects. Appropriate counseling prior to initiation of ADT is warranted, including the potentially prolonged effect of ADT on testosterone levels, with only half of patients returning to their baseline levels 2 years after stopping ADT.

To read more on this subject:
Click on Our Link

Link: ADT
or Go To
https://www.practiceupdate.com/content/testosterone-recovery-after-cessation-of-androgen-deprivation-therapy-for-prostate-cancer/85396/55/3/1

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kidney Stones

US Too Warriors:
See how to reduce Oxalates above in your diet if you have a high vitamin C diet to prevent kidney stones.
All the best Peter See Below

To read more on this subject:
Click on Our Link

Link: kidney Stones
or Go To
https://my.clevelandclinic.org/health/articles/11066-kidney-stones-oxalate-controlled-diet

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Vit C and Doxycycline

US Too Warriors:
I found a paper attached below which may help explain my great drop in PSA with casodex and metformin and dutasteride etc.

I have been taking Doxycycline for years in the hope of blocking MMPs (matrix metalloproteinases) from chewing up the proteins in the extracellular matrix thereby helping the cancer cells to escape to metastasize around the body. In the last 2 years, I added higher doses of Vitamin C (4500 mg/day and 3 pills of Berberine supplement) to my regime of Doxycycline of 100 mg/day. The article below describes how these drive the cancer to only use sugar ( glycolysis) and because it can not use anything else when you restrict your sugar intake the cancer dies when the stem cells die!!!! You have heard me preach about sugar restriction. Amen
All the best Peter See Below

To read more on this subject:
Click on Our Links

Link: Doxycycline
or Go To
http://rvaprostatecancersupport.org/PDF/6 13 19 PCa-Vitamin C and Doxycycline .pdf

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Provenge Immunotherapy

US Too Warriors:
This email discusses the many ways that Provenge immunotherapy is being studied in combinations with other PCa Treatments to try it earlier and in combination with other treatments to make it more effective. There are open clinical trials available list at the end of the email
All the best Peter See Below

To read more on this subject:
Click on Our Links

Link: Provenge
or Go To
https://www.urotoday.com/clinical-trials/from-the-editor/108202-from-the-desk-of-evan-yu-sipuleucel-t-beyond-the-impact-trial.html

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Body fat distribution linked to higher risk of aggressive prostate cancer

US Too Warriors:
Learn about Visceral fat and what you can do about it. See Below

To read more on this subject:
Click on Our Links

Link: Body Fat
or Go To
https://healthunlocked.com/advanced-prostate-cancer/posts/140944119/body-fat-distribution-linked-to-higher-risk-of-aggressive-prostate-cancer

Link: How to Get Rid of Visceral Fat
or Go To
https://www.healthline.com/nutrition/lose-visceral-fat

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Peter's Notes Page

This page is made up of the various emailed links and notes that were sent out to attendees to help
with the meeting preparation and General knowledge.

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Plant Extracts

US Too Warriors:

The figure is from the attached paper (link below). I am using 8 of the 13 supplement extracts portrayed around the outside of the figure that attack the various cancer growth factors portrayed acting on the PCa cell nucleus.
All the best, Peter

To Read more on this subject:
Click on Our Link

Link: Extracts
or Go To
http://rvaprostatecancersupport.org/PDF/6 11 19 Iqbal-2017-Plant-derived-anticancer-agents-a-g-1.pdf

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Bone Marrow

US Too Warriors:

If you are fortunate by treatment to drive your treatment to very low PSA and in the following months the PSA does not change then determining how bone mets are responding becomes a question. The book chapter attached discusses imaging for detection of changes in bone marrow. This is an issue because some PCa cancers do not produce much or any PSA!!

To Read more on this subject:
Click on Our Link

Link: Bone Marrow
or Go To
http://rvaprostatecancersupport.org/PDF/6 10 19 PCa-Detecting changes.pdf

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DIM

US Too Warriors:

I have one of these vegetables almost every night along with a DIM supplement pill at bedtime.

Last Night I made a mix of brussel sprouts and cinnamon apples - It was good. I often mix chopped broccoli with chopped cauliflower cooked by steaming often with powder garlic, olive oil, chopped onions, dried parsley, rosemary and ginger added for flavor and anticancer benefit.

To Read more on this subject:
Click on Our Links

Link: DIM
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197384/#s2title

Link: Clinical treatment
or Go To
http://rvaprostatecancersupport.org/PDF/6 8 19 DIM in Clinical treatment with enzalutamide.pdf

Link: Estrogen
or Go To
http://rvaprostatecancersupport.org/PDF/6 8 19 Estrogen.pdf

Link: Suppression of ERK and AKT pathways
or Go To
https://www.spandidos-publications.com/or/25/2/491

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Casodex and Metformin

US Too Warriors:

I use 7 off lab drugs to help fight my cancer along with my one on label drug , Casodex (bicalutamide). I would like to add another off label drug. Niclosamide (for tapeworms) but It may be hard to come by?

Metformin, I think is one of my more effective off label drugs!! Both of my brothers are also taking it. It reduces Blood sugar and insulin both bad actors for PCa.

I also take 3 grams of vitamin C per day with 100 mg of doxycycline which drive the cancer to glycolic (sugar phenotype as described in the second paper attached below) which i think is effectively acted upon by the Metformin!!!

To Read more on this subject:
Click on Our Links

Link: Metformin
or Go To
http://rvaprostatecancersupport.org/PDF/6 8 19 Metformin.pdf

Link: Vitamin C and Doxycycline
or Go To
http://rvaprostatecancersupport.org/PDF/6 8 19 PCa-Vitamin C and Doxycycline.pdf

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Lupron ADT

US Too Warriors:

This paper provides support for delaying Lupron ADT unless you have a very aggressive cancer. When I look at the survival curves it seems I am beating the odds by deferring Lupron ADT which I hope to continue to do.
Best
Peter
To Read more on this subject:
Click on Our Link

Link: Lupron ADT
or Go To
http://rvaprostatecancersupport.org/PDF/6619 ASCO 2019.pdf

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Sugar

US Too Warriors:
Sugar stimulates Insulin that PCa cells have receptors for which make the cancer grow!! If your blood insulin is already too high or your blood sugar ( glucose) it suggests you need to reduce your sugar intake. Your better numbers are in the lower normal range.

This website from 60 Minutes describes the toxicity from sugar and its brain reward effect that drives us to eat more and more. I find it the hardest thing to give up which means we have to do more exercise to try to burn it up in our muscles as well as eat less sugar that is added to many foods like Ragu spaghetti sauce etc.

I have found that many of the natural agents that fight PCa are either bitter or sour!!!

To See the 60 Minutes Video:
Click on Our Link

Link: Sugar
or Go To
https://www.youtube.com/watch?v=B56Gpf1f5_A

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Hot Sheet

US Too Warriors:
Sign up to get the Hot Sheet newsletters. June 2019 Hot Sheet :

Link: Sign up Hot Sheet
or Go To
https://www.ustoo.org/Read-the-HotSheet-Newsletter

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Example of the Newsletter's topics in 2018 here you can see some of the archive online.

To See an example:
Click on Our Link

Link: Jan 2018 Hot Sheet
or Go To
http://rvaprostatecancersupport.org/PDF/6419Us-TOO-HotSHEET-January-2018d.pdf

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Zytiga

US Too Warriors:
Doctors do not always think outside the box so you need to to be sure the treatment is right for you. For advance PCa, I am not a great fan of Zytiga as I like Xtandi better, but there are several reasons I like Casodex even better. One it is Much much more affordable, It is less likely to cause fatigue than Zytiga and Xtandi. Also Casodex on withdrawal has 20 to 30 % response if the PSA starts to go up when the Casodex is stopped. Also it can be made more effective and probably longer lasting by adding dutasteride and Metformin . If it fails on withdrawal on you can add a drug called Niclosamide
(a worm medicine pill with minor side effects usually) Which should restore it ability to lower PSA and cancer growth. Peter

To Read more on this subject:
Click on Our Link

Link: Zytiga
or Go To
http://rvaprostatecancersupport.org/PDF/6119Skip the injection.pdf

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mTOR

US Too Warriors:
Vietnam veterans exposed to high levels of Agent Orange causing high AhR activation display hyperinsulinemia and increased type 2 diabetes.48 We know exercise and diet are the best ways from preventing these problems from adding to PCa burden.

It appears that Agent Orange activates AHR ligand to higher levels that increases several PCa transcription pathways to make the cancer more aggressive. I have added several papers discussing this below. So far the only natural treatment I have found to block Agent Orange is to degrade the Heat Shock Protein 90 (HSP90), a chaperone molecule that helps AHR survive and get in to the nucleus to do its damage. I discussed how to degrade/block HSP90 in my hand out at the last meeting. Copy to follow. Also, Veterans Fishing retreat in October handout Attached below from Reel Cure for any type of cancer pass it on to a Veteran buddy too.

HSP 90 & PI3K/AKT - PCa growth Pathways and natural Inhibitors to slow cancer growth!!

HSP90 is a Heat Shock Protein ~ 90 k Daltons in size, a chaperone molecule which helps molecules fold correctly protecting them from heat and dehydration degradation. It helps protect PI3K/AKT from degradation there by aiding its growth stimulation actions. HSP90 inhibitors cause degradation of AR protein and its nuclear exclusion, whereas AR antagonist like enzalutamide also inhibits AR nuclear localization thus its transcriptional activity. Natural inhibitors of HSP90 = Green Tea, Curcumin, Korean Red Ginseng, Capsaicin.

PI3K is phosphoinositide 3-kinase, a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. Tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF 1, and in calorie restriction. PTEN (Phosphatase and tensin homolog) is a protein that negatively regulates Akt/PKB signaling pathway. (Metformin also activates calorie restriction Pathways which are shown to increase longevity in many living systems including human.) AKT is known as Protein kinase B (PKB), a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration in cancers. mTOR = mechanistic Target Of Rapamycin (mTOR) is in same family as PI3Kand like description as above.

PI3K/AKT/mTOR natural Inhibitors = Chinese Skullcaps, Quercetin, Black seed, DGL Licorice, apigenin [43], curcumin [44], cryptotanshinone [45], fisetin [46], indoles (indole-3-carbinol and 3,3′-diindolylmethane) [47], isoflavones (genistein and deguelin) [48], resveratrol [50], and tocotrienol [51]. METFORMIN made from french lilacs. Many more Inhibitors and Promoters are named in the excellent discussion at website below:

Discussion mTOR==> https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/

To Read more on this subject:
Click on Our Link

Link: mTOR
or Go To
https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/

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Antiangiogenic

US Too Warriors:
This is from the paper below. The underlined supplements are ones that i use from Swanson or LEF.org

Quote from Abstract "The herbs that are traditionally used for anticancer treatment and that are antiangiogenic through multiple interdependent processes (including effects on gene expression, signal processing, and enzyme activities) include Artemisia annua (Chinese wormwood), Viscum album (European mistletoe), Curcuma longa (curcumin), Scutellaria baicalensis (Chinese skullcap), resveratrol and proanthocyanidin (grape seed extract), Magnolia officinalis (Chinese magnolia tree), Camellia sinensis (green tea), Ginkgo biloba, quercetin, Poria cocos, Zingiber officinalis (ginger), Panax ginseng, Rabdosia rubescens hora (Rabdosia), and Chinese destagnation herbs."

I particularly recommend: Curcuma longa (curcumin), Scutellaria baicalensis (Chinese skullcap), proanthocyanidin (grape seed extract), quercetin, Korean red Panax ginseng. Camellia Sinensis (green tea) to prevent blood vessel formation to feed the cancer as it advances and gets big enough in size to be oxygen inhibit which triggers enzymes that trigger blood growth. I find grape seed extract is excellent. Quercetin, curcumin, Green tea work well in combination.

All best on US Holiday, peter

To Read more on this subject:
Click on Our Link

Link: Antiangiogenic
or Go To
http://rvaprostatecancersupport.org/PDF/52619PCa-angiogenesis Natural inhibitors I use.pdf

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Targeted biopsy of the prostate:
Improvement in detection of high-grade cancer, or the Will Rogers phenomenon?

US Too Warriors:
This is worth reading if you are on active surveillance or recently diagnosed but not had primary treatment yet or your PSA is rising but cancer has not been diagnosed by previous tests.
All best Peter

PS. I heard today we have a third man taking part in the NIH casodex/metformin trial with Dr. Bilusic.

Click on Our Link to Read more
Targeted Biopsy
or Go To
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/112599-targeted-biopsy-of-the-prostate-improvement-in-detection-of-high-grade-cancer-or-the-will-rogers-phenomenon.html
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Testosterone Recovery Profiles After Cessation of Androgen Deprivation Therapy for Prostate Cancer.

Us too Warriors:

INTRODUCTION:

Androgen deprivation therapy (ADT) is frequently used in the treatment of prostate cancer worldwide. Variable testosterone (T) recovery profiles after ADT cessation have been cited.

Best,
Peter
*
To Read more on this subject:
Click on Our Link

Link: Recovery
or Go To
https://www.ncbi.nlm.nih.gov/pubmed/31080102

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AKT/PI3K/HSP90

Us too Warriors:
I have found in my online researches that That There are two pathways HSP90 (Heat Shock Protein 90) and AKT/PI3K(phosphoinositide 3-kinase) that progress cancer growth that can be blocked by natural supplements. At this time I do not know of drugs approved that block these pathways but the drug companies are actively trying to develop them. I have found that I am taking a number of natural inhibitors of these pathways that I will describe at the May meeting. If you want to find them for yourself Google the following.

1. "Natural inhibitors of AKT/PI3K"

2. "Natural Inhibitors of HSP90"

I believe that these natural inhibitors are working in conjunction with casodex, metformin and dutasteride to produce my excellent result as my PSA went down at the end of April to 0.011 from 0.018 on Feb 1st.

All the Best, Peter

To Read more on these subjects:
Click on Our Link

Link: Natural Products
or Go To
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775843/
*
Click on Our Link

Link: AKT1
or Go To
https://en.wikipedia.org/wiki/AKT1

Click on Our Link

Link: PI3K
or Go To
https://www.sciencedirect.com/science/article/pii/S0092867417308656#go_to_%22%C3%BE%C3%BF\u0000t\u0000i\u0000t\u0000l\u0000i\u0000n\u0000k\u00001%22

Link: HSP90
or Go To
http://rvaprostatecancersupport.org/PDF/PCa-Co-targeting HSP90 51519.pdf

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Oncologist Urges PSA Screening

Us too Warriors:
U.S. Recommendation, Oncologist Urges PSA Screening - APRIL 17, 2019 BY MARY CHAPMA

Despite a United States Preventive Services Task Force (USPSTF) 2012 conclusion that routine tests for prostate cancer are unnecessary, a prominent oncologist believes such screenings should be encouraged.

To Read more on this subject:
Click on Our Link

Link: PSA
or Go To
http://rvaprostatecancersupport.org/PDF/5719US.pdf

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VA center of excellence to get Genetic Testing

Us Too Veterans:

This is a chance to go to A VA center of excellence to get genetic testing to see if you have gene mutations that can be treated more effectively by Immunotherapy or other drugs like PARP inhibitors to treat your specific cancer instead of standard care treatments that often fail against mutated cancer cells.

To Read more on this subject:
Click on Our Link

Link: VA
or Go To
https://assets1c.milkeninstitute.org/assets/ccorner/2018Hamptons/handouts/a-PCF-Veterans-Health-Initiative-Young-Investigators-Valor-Awards-1.pdf

*****************************************
Managing Prostate Cancer in Elderly/Unfit Patients

Us too Warriors:
In this Video,

Dr. Nicolas Mottet presented “Managing Prostate Cancer in Elderly/Unfit Patients” at the 6th Symposium on the Treatment of Prostate Cancer (STOP-6), which was held in Lisbon, Portugal between October 14th and 16th 2016.

Click on Our Link to see the Video
Elderly
or Go To
https://www.youtube.com/watch?v=DnZOIPnp29s&feature=youtu.be
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Prostate Cancer Active Surveillance in 2019 – Summary

In this Video,

Sigrid V. Carlsson, MD, PhD, MPH, reviews recent guidelines regarding patient selection and protocols for prostate cancer active surveillance. She provides methods for counseling patients who would benefit from active surveillance, but experience anxiety from the prospect of foregoing aggressive therapy.

Click on Our Link to see the Video
AS
or Go To
https://grandroundsinurology.com/prostate-cancer-active-surveillance-in-2019-2/?utm_campaign=Weekly%20Email%20GRU&utm_source=hs_email&utm_medium=email&utm_content=72236988&_hsenc=p2ANqtz--RjDH0JmrHrfsmlor0SoB2YtJIgGS75skuv9qnnLwUSB4l6Carajol601ize1O81CNMufX4afJtR5xEYiCFRlxq6-PPw&_hsmi=72236988

***************************************
Us too Warriors,

Check out this Swanson website if you need supplements:

To go to the Swanson Website:
Click on Our Link

Link: Swanson
or Go To
https://www.swansonvitamins.com/

Also check the Video websites below on targeted Clinic trials PARP inhibitors for advanced PCa.
Click on Our Link

Link: PARP inhibitors
or Go To
https://www.urotoday.com/video-lectures/mhspc/video/mediaitem/1108-embedded-media2018-12-12-03-06-07.html

Also check out this website:
Click on Our Link

Link: Inhibitors
or Go To
https://www.urotoday.com/video-lectures/prostate-cancer-foundation/video/mediaitem/1075-embedded-media2018-11-10-19-07-29.html?utm_source=newsletter_6502&utm_medium=email&utm_campaign=treatments-on-the-horizon-clinical-trials-in-gu-oncology

All the best, Peter
Peter Moon PhD
*
Us to Warriors,

The information to follow may explain why my Bicalutamide treatment is working so well!!!
I have found evidence in Science articles that the following Natural supplements that I use inhibit HSP90.
They are the following: Curcumin, Green Tea, and Korean Panax ginseng. The Table
near the end of the below article shows the growth proteins that promote cancer that HSP90 promotes. I have
also found papers that show Bicalutamide does not promote CRPC as does Lupron ADT and because I have had such
a remarkable lowering of PSA it should last if I am lucky for a number of years hopefully over 6?

Peter

To Read more on this subject:
Click on Our Link

Link: Bicalutamide
or Go To
http://rvaprostatecancersupport.org/PDF/4 19 PCa-Bicalutamide.pdf

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Us to Warriors,

See the below information on the benefits of metformin.

Peter

Metformin: A Bridge between Diabetes and Prostate Cancer

Prostate cancer (PCa) has become the most frequent type of cancer in men. Recent data suggest that diabetic patients taking metformin have a lower incidence of certain cancer, including PCa. Metformin is the most common drug used in type II diabetes mellitus; its use has been shown to lower the incidence of several cancers, although there are ambiguous data about the anticancer activity of metformin. A large number of studies examined the potential antineoplastic mechanism of metformin although it is not still completely understood. This review summarizes the literature concerning the effects of metformin on PCa cells, highlighting its numerous mechanisms of action through which it can act. We analyze the possible causes of the discordances regarding the impact of metformin on risk of PCa; we discuss the latest findings in this field, suggesting that metformin may have a future role in the management of PCa both as monotherapy and in combination with other drugs.

To Read more on this subject:
Click on Our Link

Link: Metformin
or Go To
https://www.frontiersin.org/articles/10.3389/fonc.2017.00243/full

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Us Too, Warriors,

Jerry Deans helped me when he Talk to our Group about 10 Years ago on how to use deep breathing meditation to reduce Anxiety and depression. I have tried it when my blood pressure was high and I have dropped my blood pressure by 15 points in about 5 minutes of deep breathing meditation as taught by Jerry Deans. Also, a supplement containing L-theanine (an extract of green tea) can help produce a similar result which I use with my wife. A cup of green tea may have a similar effect and it also helps fight PCa. The discussion below may help you.

All the best, Peter To Read more on this subject:
Click on Our Link

Link: Meditation
or Go To
http://rvaprostatecancersupport.org/PDF/Depression And Mindfulness41219.pdf

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Us Too, Warriors,

ADT is the standard of Care in advanced PCa disease. The question is: Is the lost in quality of life worth the price to be gained in survival. This paper suggests strongly that The promised gain in survival is false for many men. If you have trouble with Lupron - it is worth exploring alternative means of retarding the cancer - Examples: using diet, exercise, anti-oxidant, and anticancer supplements and off label drugs like Avodart to slow the cancer. I have met many men suffering from ADT treatment who come to our meetings over the last 24 years.

My brother, Don, now walks with a cane from the the combination of Zytiga and Lupron - before the combination he had been athletic his whole life like myself.

I tell my doctors I want to die healthy and they laugh.

All the best Peter

See Abstract below

Link: ADT Abstract
or Go To
https://www.ncbi.nlm.nih.gov/pubmed/30880568

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Us Too, Warriors,

(Comments about Dr. Bilusic's (NIH) talk on Clinic Trial with Bicalutamide (casodex and Metformin))

I hope men that may qualify after PCa recurrence will take the effort to take Part in the trial. I had good news this week that my new oncologist is going to continue on me on my Bicalutamide(casodex) and Metformin treatment that has lowered my PSA by 99%. Also I have talked to one other doctor who is willing to prescribe the treatment if you have a good response on the trial after you are off the trial in 6 to 8 months. I think in general doctors will do treatments if you have something that works for you they will continue the treatment. This a catch 22 situation.

They will not give you a treatment unless you can prove it works- The clinic trial is a way to prove it may work for you. They may also give it to you if you are ~ 80 or >. Two men I have suggest this to got because of their age and it has help them lower their PSA and a Dr. i talk with said he would give it to older men~80. I am almost their 79 in May.

What doctors do not realize is that metformin, an extract of french lilac, that has the same effect on the body as a calorie restriction diet that can add as much as 10 years to your life!!!! So it is a no Brainer and Bicalutamide if is seems to fail after a few years because the PSA again starts to rise, the withdrawal from Casodex causes a response of 20 to 30%. Of these men with a withdraw response of the PSA by going down for a while after stopping the treatment for some the cancer and some of these will be "Cured" as is the case of one of our RVA members who's PSA has not come back after more than 10 years of the treatment of any kind.

If you are going to Take part let me know so your experience can help other men of our group.

Thanks Peter

The paper below from American doctors that shows the retrospective benefit of Metformin Use in PCa.

To Read more on this subject:
Click on Our Link

Link: Metformin
or Go To
http://rvaprostatecancersupport.org/PDF/PCa-Metformin and Prostate Cancer Reduced CRPC and death in Men.pdf

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Us Too, Warriors,

This is another paper on the website below that suggests Doctors/researchers need to re-exam Androgen Deprivation Therapy(ADT). I am looking forward to seeing you at the meeting Thursday at 7 PM. The clinical trial that will be discussed by Dr. Bilusic using Casodex with Metformin raises the Testosterone in most men but keeps it from going into the cancer cells as Casodex is an anti-androgen that blocks the testosterone receptor on the cancer cell surface. With me being on similar treatment (higher Casodex and lower Metformin for me), it has doubled my testosterone and raised my Free testosterone in the process of lowering my PSA by 99 %. I send you a paper last week that showed that men with low testosterone when diagnosed had higher gleason scores when their prostate was examined after surgery. I think this evidence needs to be examined as we need to rethink androgen deprivation therapy to know when it is helpful or harmful and not follow the ADT path blindly. See Website below.

To Read more on this subject:
(Testosterone Slows Prostate Cancer Recurrence in Low-Risk Patients)
Link: Recurrence
or Go To
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/111033-testosterone-slows-prostate-cancer-recurrence-in-low-risk-patients.html

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Us Too, Warriors,

Please find the paper below which indicates the possible benefits for adding Metformin to your PCa treatment.

I hope to see you at the meeting next thursday at 7 PM to hear about the clinical study testing Metformin with Casodex at NIH - As many of you know it has lowered my PSA 99% even with a bone and multiple lymph node mets. Everyone's PCa can have a different response but is important to try treatments with small side effects to see if your cancer will respond. All the Best, Peter

To Read more on this subject:
Click on Our Link

Link: Metformin
or Go To
http://rvaprostatecancersupport.org/PDF/Metformin.pdf

***********************
Us Too Warriors

See some recent research for your info below. The NIH video ( last below) with Dr Gulley I think is related to the upcoming talk by Dr Bilusic as they work together at NIH.
All the Best Peter

Immunotherapy Across Genitourinary Malignancies - James Gulley

In this interview, James Gulley recaps the Keynote Lecture he gave at the GU ASCO 2019 annual symposium discussing immunotherapy across genitourinary malignancies and the different advancements in prostate, kidney and bladder cancer.

Click on Our Link to see the Video
Genitourinary
or Go To
https://www.urotoday.com/video-lectures/asco-gu-2019/video/mediaitem/1153-embedded-media2019-02-23-00-18-04.html?utm_source=newsletter_6350&utm_medium=email&utm_campaign=prostate-cancer-daily

Long-term Outcomes of Stereotactic Body Radiotherapy for Low-Risk and Intermediate-Risk Prostate Cancer.

Stereotactic body radiotherapy harnesses improvements in technology to allow the completion of a course of external beam radiotherapy treatment for prostate cancer in the span of 4 to 5 treatment sessions.

Click on Our Link to Read more
Stereotactic
or Go To
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/110247-long-term-outcomes-of-stereotactic-body-radiotherapy-for-low-risk-and-intermediate-risk-prostate-cancer.html
*
Evidence-Based Chemotherapy for Oligometastatic Prostate Cancer

In this interview,
Dr. Haffizulla: So, let’s talk a little bit about evidence-based chemotherapy for oligometastatic prostate cancer. You have actually recently written about chemo for patients with this disease state. What does the literature say about efficacy of chemo for this patient population?

Click on Our Link to see the Video
Evidence-Based
or Go To
https://www.practiceupdate.com/content/evidence-based-chemotherapy-for-oligometastatic-prostate-cancer/64205
***********************************
Us Too, Warriors,

At the Mar 2019 meeting:
Dr Bilusic will discuss two trials one is after Biochemical recurrence following Surgery or Radiation treatment with Casodex
and Metformin and the other trial is immunotherapy for men that have castration resistant cancer.

Click on Our Link to read more on "Join A Clinical Trial: Casodex (bicalutamide) + Metformin"

Link: trials
or Go To
http://rvaprostatecancersupport.org/PDF/Clinical Trial Casodex.pdf

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Us Too, Warriors,

We all know that exercise is of great value with age even with out advanced cancer.
It is hard to keep it up as we should during the winter's bad weather months, but is a must.
The book listed in the article below may be useful.

To Read more on this subject:
Click on Our Link

Link: Exercise
or Go To
https://www.clinical-genitourinary-cancer.com/article/S1558-7673(18)30721-3/fulltext

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Us Too, Warriors,

It is known that excess calcium and animal fats from milk promote PCa cell initiation/growth.

The copied info below also shows that it also is associated with biochemical recurrence and death 8 years after primary treatment. I have not been drinking milk for almost 25 years and my very high consumption of Dairy products-cheese and milk I believe was a strong contributor to my development of Prostate Cancer. Cooked tomatoes (Lycopene) and green tomatoes are good in fighting PCa.
All the Best Peter

To Read more on this subject:
Click on Our Link

Link: Milk
or Go To
http://rvaprostatecancersupport.org/PDF/Whole Milk.pdf

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Us Too, Warriors,

We all need to be reminded to eat right and exercise to fight our PCa!!!
The effect of diet and lifestyle in prostate cancer progression and mortality is the subject of the below article.

To Read more on this subject:
Click on Our Link

Link: lifestyle
or Go To
https://medivizor.com/blog/SampleLibrary/prostate-cancer/the-effect-of-diet-and-lifestyle-in-prostate-cancer-progression-and-mortality/
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Us Too, Warriors,

The video below discusses Focal therapy at this time. It is definitely buyer be aware at this time - but it is improving.
I do not know of it being practiced in Virginia yet because I have not looked into it.

To see the video:
Click on Our Link

Link: Focal Therapy
or Go To
https://grandroundsinurology.com/prostate-cancer-focal-therapy-is-it-the-right-time-for-your-practice/

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Us Too warriors,

The paper below may give you Ideas to help you fight your cancer,
Stay Warm.
Peter

Plants Against Cancer: A Review on Natural Phytochemicals in
Preventing and Treating Cancers and Their Druggability

To Read more on Plants Against Cancer:
Click on Our Link

Link: Plants
or Go To
http://rvaprostatecancersupport.org/PDF/PCa-Plants Against Cancer- A Review on Natural Phytochemicals in fighting cancer.pdf

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Us Too warriors,

The below is information I have used over the last 20 years to control my cancer !!!

1st link - Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer
2 nd link - Avodart & Proscar for Treating Prostate Cancer
3rd link - Does PSA Promote Prostate Cancer?

To Read more on this subject
Click on Our Links

1. Link: Antiandrogen
or Go To
https://www.nejm.org/doi/full/10.1056/NEJMoa1607529
2. Link: Avodart & Proscar
or Go To
https://www.verywellhealth.com/avodart-proscar-for-treating-prostate-cancer-2782131
3. Link: PSA
or Go To
https://www.lifeextension.com/Magazine/2005/6/awsi/Page-01

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Us Too warriors,

Below is an attachment that may help with your planning for your next Doctor's meeting. Feel free to modify the meeting page to fit your concerns and conditions. The Jan 17th 2019 meeting will give you a chance to hear other men's concerns and this should help you ask better questions of your Doctor.

In My situation, I am starting with a new doctor (oncologists- my fifth)
I want to know the following:

1. Will he be willing to order my Blood tests at least a week before I see him? (so I can know my situation before my visit)
2. Will he be willing to order most of the blood tests I request?
3. Will he be willing to continue to prescribe the 7 adjuvant prescriptions my other oncologist have ordered over the last 18 years?
4. Has he treated any PCa patients with Casodex and Avodart (plus adjuvants Like metformin, curcumin ,quercetin, aspirin etc,etc.)?
5. If my PSA stops falling and starts to rise how would he image my mets.?
6. How would he follow my mets even if the PSA is stable?

I am in contact with Dr.Myers and He sent me the paper attached below showing the importance of Adequate Vitamin D3 for brain health (Alzheimers, Parkinson , dementia, MS). I hope you are maintaining your Vit D in the winter.

ALL the best, Stay warm.
Peter

To Read more on this subject
Click on Our Link

Link: Questions
or Go To
https://www.knowyourprostateplan.com/prostate-cancer-questions

To Read more on Vit D
Click on Our Link

Link: Vit D
or Go To
http://rvaprostatecancersupport.org/PDF/WebPage (1).pdf

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Us Too warriors,

12 Nutrients that Target & Destroy Cancer Stem Cells consider using them if you are not already including them in your diet to fight cancer.

Best Wishes for the new year. Peter

To Read more on this subject
Click on Our Link

Link: Nutrients
or Go To
https://thetruthaboutcancer.com/12-nutrients-destroy-cancer/#

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Us Too warriors,

I have added a short video email below which shows the difference between the approach of experienced prostate cancer Oncologists and urologists in their approach to using hormone agonist like lupron to treat rising PSA after primary treatment.

You can guess my approach as I have avoided Lupron for 19 years with rising PSA indicating BCR after surgery 24 years ago.

All the best for the New Year Peter

To see the Video
Click on Our Link

Link: ADT
or Go To
http://www.researchtopractice.com/PCUTT112/Video/1

To hear any of the 43 audio Tracks connected with the videos from this talk

Click on Our Link

Link: Audio
or Go To
http://www.researchtopractice.com/PCUTT112
*
Us Too warriors,

Fortunately that many of us have good relations with our Doctors. I do hear of doctors that will not respond to help patients get the treatment they want. The article below describes such a problem.
Best Wishes for the new year. Peter

To Read more on this subject
Click on Our Link

Link: Pink Slip
or Go To
https://www.curetoday.com/community/sarah-debord/2018/12/giving-your-provider-the-pink-slip
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Us Too warriors,

My Oncologist has retired - fortunately he has given me my prescriptions for about the next Year. But, I am looking for a new Doctor so you may benefit from my efforts I have include a list of Oncologists in Virginia and The USA. See below
Peter Moon PhD

To Read more on this subject
Click on Our Link

Link: New Doctor
or Go To
https://npidb.org/doctors/allopathic_osteopathic_physicians/hematology-oncology_207rh0003x/va/?page=1
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Us Too warriors,

Consider adding Curcumin to your amentarium to fight PCA. Researchers are intrigued by a promising discovery that curcumin selectively starves tumor cells to death.
1. Curcumin does this by depriving cancer cells of the ability to make and use ATP, the energy currency within cells.
2. Since most cancer cells generate ATP in a different way than healthy cells, curcumin selectively kills tumor cells with no impact on healthy tissues.
These newly uncovered energy-disrupting properties of curcumin further support the preventive potential of this botanical compound.
See below

Peter Moon PhD

To Read more background info on this subject
Click on Our Link

Link: Curcumin
or Go To
http://rvaprostatecancersupport.org/PDF/Curcumin Life Extension Magazine.pdf
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Us Too warriors,

Thousands of Americans turn to medical attention to help improve their quality of life and relieve them of pain and suffering. Medications and implant surgeries, such as hip or knee replacement, can change and even save lives.

However, pharmaceutical companies often cut corners where accuracy matters most – consumer safety. Insufficient lab testing and deceptive marketing tactics have cost thousands of patients their lives. Prescription medications have caused users to suffer detrimental side effects and implant surgeries have left victims in great pain. Pharmaceutical companies earn billions of dollars every year from these products at the expense of their users.

To Read more background info on this subject
Click on Our Link

Link: Drug & Devices Dangers
or Go To
https://www.drugdangers.com/drugs-devices/
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Us Too Warriors,

I tried to sign up for this trial last winter (Baltimore ORIOLE trial for Oligio Metastasis).
I was too late and they wanted me to get off of Casodex and Avodart so my PSA would double in less than 15 months. My PSA had already dropped by 90 % in one month on Casodex so I was not going to do it anyway after I learn how well the Casodex was working. I am still exploring SBRT for my mets and possible HI Fu focused on the mets. I have to figure what my cancer is doing with my ultra low PSA. This seem to be uncharted waters which I have to figure out. The SBRT treatment in Oriole Trial was able to improve Progression free time over no treatment as shown below.
All the Best, Peter

To Read more background info on this subject
Click on Our Link

Link: Casodex
or Go To
http://rvaprostatecancersupport.org/PDF/SUO 2018.pdf
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Us Too Warriors,

Another supplement (DIM) to consider to slow PSA. At the last meeting(Nov 15,2018), I spoke on how estrogen(Estradiol) could promote PCa with higher Gleason `7,8,9,10 and advanced cancers. Please find discussion of another supplement besides Fisetin below. DIM is in Cabbage, Broccoli, Brussel Sprout &,Cauliflower.

To Read more background info on this subject
Click on Our Link

Link: DIM
or Go To
http://rvaprostatecancersupport.org/PDF/ProductsNaturesWay112018.pdf
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Us Too Warriors,

I think My talk tomorrow (Nov 15, 2018) will give unique insights on How Estrogen can grow or slow many cancers and particularly Prostate cancer . Bring the Hand out with you if you can print it out. It is below in PDF file. If you do not have a PDF file reader you can down load one free from:
https://get.adobe.com/reader/

To Read more background info on this subject
Click on Our Link

Link: Estrogen
or Go To
http://rvaprostatecancersupport.org/PDF/KIC Document 0001.pdf
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Us Too Warriors,

My research has uncovered what I believe will prove to be a Grand Slam treatment for multiple cancers. In my family, my siblings and I are fighting PCa(2). Lung Cancer, Kidney cancer, Melanoma(2) besides squamous and basal cell skin cancer. I believe this combination treatment will help treat all these cancers. In my talk(Nov 15, 2018 Meeting), I will discuss this treatment I stumbled on to and was using for other reasons with out knowing it has strong cancer fighting abilities. I have have been using it for 10 months to fight the side effects Casodex - during which I have had a remarkable PSA response to Casodex and Dutasteride by lowering my PSA by 99.9%. I only learn of this combination(Melatonin and Fisetin) treatment's benefits in fighting cancer when I found out it was great for fighting melanoma for which I had my second positive biopsy last week and I was studying scientific literature for it. This exceptional PSA drop is much better than reported in the literature for this treatment. I believe that my use of Melatonin (30 mg at night) and 600 mg of Fisetin per day has made my treatment so unusually effective along with the other supplements I also take.

Green tea, apples, onions and strawberries are the best sources of Fisetin but they are really weak - Green tea is the best as ECC tea molecules is similar to Fisetin and all these are good anticancer foods. Fisetin is flavone in the family of of apiginen and quercetin which are considered prostate cancer fighters I use. But, Fisetin seems to stand out as it inhibits many many cell pathways that differ in different cancers.

To Read more background info on this subject
Click on Our Link

Link: Fisetin
or Go To
http://rvaprostatecancersupport.org/PDF/11718PCa-Fisetin melatonin ehances the anti-toumor Effect of fisetin.pdf
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Us Too Warriors,

See This Nov Prostatepedia issue below on imaging to detect your cancer so you can pick the best treatments.
All the best, Peter
Link: Nov
or Go To
http://rvaprostatecancersupport.org/PDF/PCa-Prostatepedia_November2018_V4N3.pdf

The Importance of PSA Doubling Time (PSADT) and Metastases-Free Survival (MFS)
Click on Our Link to read the Article
PSADT
or go to:
https://grandroundsinurology.com/pca-commentary-volume-122-May-2018/

RADIOLIGAND THERAPY (RLT) with 177-LUTETIUM:
Forthcoming Treatment Option Likely to Upgrade the Management of Advanced Prostate Cancer in the Near Future.

Click on Our Link to read the Article
RADIOLIGAND
or go to:
https://grandroundsinurology.com/pca-commentary-volume-123-June-2018/

NEUROENDOCRINE PROSTATE CANCER:
An Adverse Development in Advanced Disease — Which Largely Has Flown Under the Radar.

Click on Our Link to read the Article
NEUROENDOCRINE
or go to:
https://grandroundsinurology.com/pca-commentary-volume-125-August-2018/
DECIPHER AND A HYBRID CLINICAL – GENOMIC CLASSIFIER:
Improving the Prognostic Accuracy of NCCN Risk Categories

Click on Our Link to read the Article
DECIPHER
or go to:
https://grandroundsinurology.com/pca-commentary-volume-127-October-2018/
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Us Too Warriors,

See the attachment (abstract below) to be aware of other cancers - so you do not only focus on PCa. One of our members has recently diagnosed with Lymphoma, I have had three skin cancers in the last two years and I am going to get a new biopsy soon for possible melanoma ( I have had one already removed recently). At The Va B Conference last Saturday, a speaker discussed increases in second cancers in men with PCa- Among them were melanoma, lung, pancreatic and colon as best I remember. I will send the slides when I get them.

Stay Strong in the Fight, Peter

See abstract that follows:

Click on Our Link
Link: abstract
or Go To
https://onlinelibrary.wiley.com/doi/epdf/10.1002/cam4.1764
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Us Too Warriors,

RVA Us too was well representative at the Va beach Prostate meeting on Saturday as I counted at least 12 of our group present. It is the best PCa conference for Patients I have been to. I may get an email of the presentation slides/Videos which I will send out when they are available.

I hope you can make Thursdays meeting on Proton therapy. This treatment is best if the cancer has not advanced or is not high Gleason or outside of the capsule like for all radiation treatments. Its claim to fame is lower side effects. I know of six men in our group who have been treated - two recently treated. And of the four longer times since treatments three seem to have good results with minimum side effects. The third man has had progression/PSA recurrence. This recurrence is usually a sign the the cancer had escaped before the proton (or any radiation) treatment and emphasizes the importance in any treatment of knowing where the cancer is to chose the best treatment.

The abstract that follows suggest that zinc supplement may reduce androgen (testosterone) receptors to slow PCa growth. The maximum supplement dose per day is 50 mg /day as 80 mg/day is considered toxic.

I usually take between 25 to 35 mg/day to slow PCa. Pumpkin seeds are a common source of zinc.
See abstract that follows all the best - Peter

Click on Our Link
Link: abstract
or Go To
https://www.ncbi.nlm.nih.gov/pubmed/30297600
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Us Too Warriors,

This Post contains a video which compares the Radiation procedures for PCa and shows the advantages of SBRT treatment.
All the Best Peter

To see the Video
Click on Our Link
Link: Video
or Go To
https://grandroundsinurology.com/hypofractionation-for-prostate-cancer/?utm_campaign=Weekly%20Email%20GRU&utm_source=hs_email&utm_medium=email&utm_content=66429800&_hsenc=p2ANqtz-9G4C9d12xSXwk3CEJRTFqcMDKrpyshTYEHjSLFYaJz3Nl22Ho56sG-5u7KxCndodhiE_G9TZ2PVgAAZaZSozIeXKOVVw&_hsmi=66429800
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Us Too Warriors,

Please find below more Clinical trial information on the effectiveness
of SBRT treatments for PCa. This is a follow up on the information from September's
meeting by Dr. Cuttino.

All the Best,
Peter

Per the Requests for the Power Point Presentation
"The September 20th meeting"

Dr. Lauri Cuttino, VCUHS Assoc. Prof. of Radiation Oncology at VCUHS and the Medical Director of Radiation Oncology at the Sarah Cannon Cancer Center at Henrico Doctors' Hospital, who discussed Stereotactic Ablative Radiotherapy for Prostate Cancer and gave a Power Point Presentation: Treatment of Primary and Limited Metastases.

To Read the Power Point Presentation in PDF format
Click on Our Link

Link: PDF
or Go To
http://rvaprostatecancersupport.org/PDF/Prostate SABR no video 92318.pdf

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More Clinical trial information on the effectiveness of SBRT treatments

To Read the Clinical trial information
Click on Our Link

Link: SBRT
or Go To
http://rvaprostatecancersupport.org/PDF/SBRT Phase 2 Multicenter Trial of Heterogeneous.pdf

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Minimizing Morbidity and Maximizing Outcomes with ADT
Posted by Laurence Klotz, MD, FRCSC | Aug 2018

Us Too Warriors,
This is important - if your Doctor puts you on ADT for advance cancer.

To Read the report
Click on Our Link
Link: ADT
or Go To
https://grandroundsinurology.com/minimizing-morbidity-and-maximizing-outcomes-with-adt/?utm_campaign=Weekly%20Email%20GRU&utm_source=hs_email&utm_medium=email&utm_content=66041458&_hsenc=p2ANqtz--gzjvSnuCVVmCb65bs4lQi_p-9foUKelnBo460WOvlSQEek0bgxl8GCGQO0ADL9bdrsR69RsjqhM3JChZ43Gv2HGFMRw&_hsmi=66041458

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The story of Anti-androgens and why they can be better than androgen deprivation therapy for PCa

Us Too Warriors,

As many of you know I have had great success lowering my PSA even with a bone and multiple Lymph nodes mets 24 year after PCa Diagnosis and surgery. I am using Dutasteride and Casodex (150 mg/ day anti-androgen) as my combined mono therapy which in the literature was equivalent in progression free survival to ADT without the many quality of life problems of ADT.

This website address is for a video that discusses the development of Anti-androgens for PCa treatment as described by the author in the attached paper below:

All the Best,
Peter

To Read the report
Click on Our Link
Link: Androgen
or Go To
http://rvaprostatecancersupport.org/PDF/PCa-Crawford-2018-Androgen-receptortargeted-treatment.pdf

To watch the video
Click on Our Link
Link: Video
or Go To
https://www.urotoday.com/video-lectures/prostate-cancer/video/mediaitem/981-embedded-media2018-06-24-01-48-26.html
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Active Surveillance (8/11/18)

Us Too Warriors,
This email discusses many of the aspects of active surveillance. Some of the procedures to control the cancer at this early stage may apply after you have had primary treatment and may help slow biochemical or more advanced recurrence. All the Best Peter
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Active Surveillance: Who is the Right Patient? - Matthew Cooperberg, MD
Matthew Cooperberg, MD and Charles Ryan, MD discuss active surveillance in the low risk and low volume disease setting. The topics they highlight include defining the appropriate patient for active surveillance in 2018 and reaching a global consensus, how much age factors into active surveillance, how biomarkers and imaging are driving research and decision making in the active surveillance setting and where lifestyle, diet, and exercise fits in.

Click on Our Link
Link: Right Patient
or Go To
https://www.urotoday.com/video-lectures/eau-2018-gu-oncology/video/mediaitem/931-embedded-media2018-03-28-13-38-21.html?utm_source=newsletter_5680&utm_medium=email&utm_campaign=informed-decision-making-about-active-surveillance
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Use of Conservative Management for Low-Risk Prostate Cancer - Interview with Stacy Loeb
Stacy Loeb, MD, and Alicia Morgans, MD discuss conservative management, active surveillance, and management trends over time for low-risk prostate cancer in the Veterans Affairs Integrated Health Care System over the past decade.

Click on Our Link
Link: Low-Risk
or Go To
https://www.urotoday.com/video-lectures/prostate-cancer/video/970-embedded-media2018-06-14-16-15-42.html?utm_source=newsletter_5680&utm_medium=email&utm_campaign=informed-decision-making-about-active-surveillance
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Long-Term Outcomes of Active Surveillance for Prostate Cancer - Interview with Sigrid Carlsson
Sigrid Carlsson, MD talks with Alicia Morgans, MD about long-term outcomes of active surveillance for prostate cancer, a 17-year experience with active surveillance at the Memorial Sloan Kettering Cancer Center. A study which Carlsson was a co-author on and was presented at the most recent American Urological Association meeting (AUA2018).

Click on Our Link
Link: Active Surveillance
or Go To
https://www.urotoday.com/video-lectures/advanced-prostate-cancer/video/968-embedded-media2018-06-12-21-17-08.html?utm_source=newsletter_5680&utm_medium=email&utm_campaign=informed-decision-making-about-active-surveillance
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Describing Perspectives of Health Care Professionals on Active Surveillance for the Management of Prostate Cancer
This article reports on a series of 5 focus groups with healthcare practitioners, exploring their perspectives about active surveillance. The sessions were held in several hospitals that specialize in the treatment of prostate cancer and included 48 physicians who provided care to men with low-risk prostate cancer and engaged in conversations with the men and their families about active surveillance.

Click on Our Link
Link: Management
or Go To
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/105173-describing-perspectives-of-health-care-professionals-on-active-surveillance-for-the-management-of-prostate-cancer-beyond-the-abstract.html?utm_source=newsletter_5680&utm_medium=email&utm_campaign=informed-decision-making-about-active-surveillance
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Active Surveillance in the Real World: What Have ProtecT and Other Prospective Trials Taught Us?
Freddie Hamdy, MD, started the Precision Active Surveillance in Prostate Cancer session by discussing the role and impact of ProtecT and other prospective trials on how active surveillance is disseminated in the real world.

Click on Our Link
Link: Trials
or Go To
https://www.urotoday.com/conference-highlights/asco-2018/asco-2018-prostate-cancer/104918-asco-2018-active-surveillance-in-the-real-world-what-have-protect-and-other-prospective-trials-taught-us.html?utm_source=newsletter_5680&utm_medium=email&utm_campaign=informed-decision-making-about-active-surveillance
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When Can Active Surveillance be Less Active? Prediction of Long-term Non-reclassification for Men with Low-risk Prostate Cancer
Matthew Cooperberg, MD presented results of predictors of long-term non-reclassification for men with low-risk prostate cancer.

Click on Our Link
Link: Low-risk 2
or Go To
https://www.urotoday.com/conference-highlights/asco-gu-2018/asco-gu-2018-prostate-cancer/101806-when-can-active-surveillance-be-less-active-prediction-of-long-term-non-reclassification-for-men-with-low-risk-prostate-cancer.html?utm_source=newsletter_5680&utm_medium=email&utm_campaign=informed-decision-making-about-active-surveillance
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Prevent PCa Drug Treatment Failure (8/1/18)

Us Too Warriors,
Please read pages 7 to 9 in the Attached report to learn how you (not the Doctor) can prevent PCa drug treatment failure.
On other pages (page 6) you can read how to use supplements to make radiation treatment more effective in killing the cancer.
I am using most of the supplements listed on page 9 but mainly Curcumin, Green tea and Quercetin to keep my Casodex and Avodart
drug treatments long lasting now that Casodex has been reduced my PSA by 99.9 %. Enjoy Peter

Click on Our Link
Link: Supplements
or Go To
http://rvaprostatecancersupport.org/PDF/PCa-Blaylock report on Supplements.pdf
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SBRT (7/21/18)

Us Too Warriors, The September 20th meetings will focus on Stereo-tactic Body Radiation Therapy (SBRT) which a precision medicine way of beating back the cancer after it has escaped primary treatment (surgery or radiation usually) and is still only located in few lymph nodes bone or soft tissue areas. A number of the concerns in choosing this treatment are outlined in the article attached below.

Click on Our Link
Link: SBRT
or Go To
http://rvaprostatecancersupport.org/PDF/PCa- SBRT Hot area Olgiometastasis treatment J Nucl Med-2018-Jadvar-jnumed.118.213470.pdf
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Avodart (7/11/18)

Us Too Warriors, The paper that follows describes the use of Dutasteride (Avodart) (which by itself worked for me for 15 years as long as my PSA stayed below 1.0 ng/ml) with Bicalutamide (Casodex) which I started in December 2017 and has reduced my PSA from 12.2 ng/ml to 0.0176. This is not a permanent "cure"even thought it may be for 20% by a mechanism called "Withdrawal" when it seems to stop working after some years. We have had this "cure" for one of our members now going on 15 years who at 42 years had advanced 8 & 9 Gleason thru out his prostate. It has been working for one other older member of our group dropping his PSA from 30 something to the low single digits.

For me, it is a better choice than ADT with lupron which is the common standard of care that has heart related side effects among the 13 reported adverse side effects. The main side effects of Casodex are Breast enlargement and nipple sensitivity form added estrogen I take Femara (anti-estrogen) to reduce the effects of estrogen from aromatase action on high testosterone to turn some into estrogen. I am looking at some additional anti-estrogens as estrogen over the long haul may contribute to PCa growth.

All the best and Stay cool,
Peter

Click on Our Link to Read this information

Link: Avodart
or Go To
https://springerplus.springeropen.com/articles/10.1186/s40064-016-2280-8
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Fatigue on Androgen Deprivation Treatment (6/21/18)

Us Too Warriors, Gene analysis may tell if you are prone to Fatigue on Androgen deprivation treatment

See abstract below:

Genetic predictors of fatigue in prostate cancer patients treated with androgen deprivation therapy: preliminary findings.

Click on Our Link to Read this latest information

Link: Fatigue
or Go To
https://www.sciencedirect.com/science/article/pii/S0889159112000657
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Prostate cancer's penchant for copper may be a fatal flaw (6/21/18)

Prostate cancer's penchant for copper may be a fatal flaw
Published Friday 17 October 2014
Adapted Media Release

Like discriminating thieves, prostate cancer tumors scavenge and hoard copper that is an essential element in the body. But such avarice may be a fatal weakness.

Click on Our Link to Read this latest information

Link: Copper
or Go To
https://www.sciencedaily.com/releases/2014/10/141015084514.htm
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Us Too warriors (4/19/18)

Low Testosterone Linked to Chronic Disease in Younger Men by Seth Augenstein

Low testosterone, a condition that affects several million men in the United States alone, is linked to chronic health conditions in younger men, according to a new study.

Read the latest information.

Click on Our Link
Link: Low Testosterone
or Go To
http://rvaprostatecancersupport.org/PDF/Low Testosterone Linked to Chronic Disease in Younger Men.pdf
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Blocking Inflammation (6/20/18)

US Too Warriors, I have spoken about many times at meetings about the importance of blocking inflammation that promotes cancer growth and oxidation which damages genes making the cancer more aggressive so that many of our treatments stop working in time from the gene mutations. This has been a corner stone of my self direct treatment which after the last 6 months on Casodex and Avodart has lowered my PSA by 99.9% to 0.0176. With this number below 0.02, research suggest I may be able to expect a relative long run~ 6 years? on this treatment - only time will tell.

Peter Moon PhD

The paper that follows talks about breast cancer but it applies to most solid cancers including PCa!!!

LIFE EXTENSION

Click on Our Link to Read this latest information

Link: Blocking Inflammation
or Go To
http://www.lifeextension.com/Magazine/2011/11/The-Inflammatory-Factor-Underlying-Most-Cancers/Page-01
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Polyphenols and phytochemicals (5/5/18)

Us Too Warriors, Add these to your amour as you can. All the Best Peter

Phytochemicals are the gifts from nature, which are responsible for the colour, taste and aroma of plant based foods. As well as these pleasant attributes, they protect us from environmental and ingested carcinogens and have anticancer properties. It is not a surprise then that the World Cancer Research Fund and other academic bodies, report that individuals eating phytochemical-rich foods have a significantly lower risk of cancer or relapse after treatments.

This article provides an overview of the major classes of phytochemicals, particularly polyphenols, with examples of their common food sources. It highlights the international evidence for their anti-cancer mechanisms of action and other clinical benefits, as well as discusses the pros and cons of concentrating them into nutritional supplements to harness and boost their health benefits.

Click on Our Link to Read this latest information

Link: Polyphenols
or Go To
http://www.cancernet.co.uk/polyphenols.htm
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Us Too warriors (4/30/18)

Obesity has been reported to make Prostate cancer more aggressive. The report below shows that it also starts some cancers (prostate was not evaluated) . This morning I just hit my High school weight of 149 lbs (first time in 50 years) after cutting the lawn with my push mower and playing 2 hours of soccer in spite if eating a lot on Sunday.

Click on Our Link to Read this latest information

Link: Obesity
or Go To
http://rvaprostatecancersupport.org/PDF/Obesity.pdf
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Us Too warriors (4/5/18)

HOPA 2018: Abiraterone Adequately Suppresses Testosterone Without Androgen Deprivation Therapy in Castration-Resistant Prostate Cancer

Read the latest information.

Click on Our Link
Link: HOPA
or Go To
http://rvaprostatecancersupport.org/PDF/HOPA 2018.pdf
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Us Too warriors (3/17/18)

Subject: High Cost of Xtandi

Us Too warriors,
If your cancer is advanced you may be interested in this website to lower the high cost of Xtandi (Enzalutamide).
Peter

Click on Our Link
Link: Cost
or Go To
https://xtandihcp.com/support-financial?utm_source=N6246.905338.UROTODAY.COM&utm_medium=Banner&utm_term=214812333&utm_content=0762740PM_728x90&utm_campaign=2017+Xtandi+Display&dclid=CLbbxdqk89kCFY9TDAodvsoKRQ#isi
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Us Too warriors (3/15/18)

Subject: PCa both hormone naive or CRPC with and without mets

Us Too warriors,
See if you can access this website to discuss treatment for men with PCa both hormone naive or CRPC with and without mets. Peter

Click on Our Link
Link: PCa
or Go To
https://rise.articulate.com/share/0ZY0q9yhwPPRXLPZHRM7HqhZzWIS6wU_#/lessons/cj47j7rb700003i64376te02f?_k=cjhga8
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Us Too warriors (3/15/18)

Subject: March 15 Meeting Handout

Us Too Warriors, I hope you can make the meeting tomorrow night. I will be discussing what I have learn about treating advanced cancer which discusses what most doctors will recommend to you if your cancer has progressed at this time. This is a fast moving field and it is not something we have discussed ever at our meetings.and it may be changed over the next several years with more studies and treatments come out.

Ps. I continue to do unbelievably well as my PSA has now drop more than 99% in 3 months to 0.106 as I travel at less beaten path. I will have to wait for sometime in the future for imaging to tell me what it means???

But for now I am a happy camper! See below:for handout

All the best to you in your efforts, Peter

Use the Link below to get the Handout

Click on Our Link
Link: Handout
or Go To
http://rvaprostatecancersupport.org/PDF/Handout March 15 Meeting.pdf
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Us Too warriors (3/10/18)

Subject: Genes and the Analysis

Below is one of my genes and analysis on how it reduced my Dihydrotestosterone(DHT)to lower my PCa chances. Also, I had a very good response to Finasteride and Avodart drugs after I had PCa to lower the PSA to undetectable by blocking DHT in the year 2000. I am still using it with Casodex as helps it with ADT and Anti-androgen treatments making them more effective. It is more complex than this one gene as you will see by reading below. But by taking Finasteride/Avodart(dutasteride) pills you will block a lot of this growth pathway to slow your PCa.

Use the Link below to See What you think?

Click on Our Link
Link: Gene
or Go To
http://rvaprostatecancersupport.org/PDF/Gene002.pdf
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Us Too warriors (3/1/18)

Subject: Importance of Magnesium for Vitamin D Utilization

Please read the attached paper which shows the importance of magnesium for vitamin D utilization and it also helps with bone health and calcium reduction in your arteries. The usual dose (RDA) for men is 420 mg/day but with my high vitamin D supplementation, I take 2 pills of 500 mg per day. If you take more than enough your stool will be loose. If you have trouble getting your Vitamin D level high enough (60 to 80 ng/ml) in your blood this may help.

All the Best
Peter
Use the Link below to See What you think?

Click on Our Link
Link: Utilization
or Go To
http://rvaprostatecancersupport.org/PDF/Vitamin D-Magnesium is need for metabolism.pdf
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Us Too warriors (2/16/18)

Subject: Milk and Other Dairy Foods in Relation to Prostate Cancer Recurrence
and Monk baldness pattern.

The Prostate - TAKE-HOME MESSAGE

The authors assessed the impact of dairy (specifically whole milk) on the risk of recurrence in patients with prostate cancer (N = 1334). Results showed that men who consumed four or more servings per week of whole milk had a 73% increased risk of recurrence compared with men who consumed fewer than three servings per month. Among very overweight and obese men (BMI ≥27 kg/m2), more than four servings per week vs none to three servings per month of whole milk was associated with a threefold higher risk of recurrence.

Results suggest that whole milk may confer an increased risk of prostate cancer recurrence, especially in obese men. This information should be included in discussions about lifestyle and conservative modifications that may improve a patient's overall cancer risk.
– Gautam Jayram, MD
Recent research From the university of South Carolina found that men with "Monk baldness pattern ie. bald in circular pattern at peak at the back of the head" have a high level of an enzyme that damages the hair follicle's that also increases the migration and spread of cancer making it more likely to be aggressive PCa. So if you have this hair pattern you may need to take more aggressive action to stop PCa or its recurrence.
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Us Too warriors (2/10/18)

Subject: Grape Seed Extract

Us Too Warriors,
I have used Grape seed extract for about 10 years after one of my students told me that his father with PCa used Grape Seed extract to lower his PSA significantly.
Use the Link below to See What you think?

Click on Our Link
Link: Grape Seed Extract
or Go To
http://rvaprostatecancersupport.org/PDF/Grape seed extract.pdf
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Us Too warriors (1/31/18)

Subject: A new weapon against bone metastasis?

Promising antibody treatment (15D11) for bone mets that may go to Clinical trial soon??? With my recent diagnois of Bone mets to my hip, I am looking at Bone mets treatments.

Click on Our Link
Link: Bone Mets
or Go To
https://www.princeton.edu/news/2017/12/11/new-weapon-against-bone-metastasis-princeton-lab-develops-antibody-fight-cancer
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Us Too warriors (1/21/18)

Subject: Exercise may positively alter tumor biology

Us Too Warriors - The attached paper discribes the clinical trial on Exercises for bone mets.
This may be hard to do if you are in pain and if the damage may cause fracture. This study has not been report as it is on going - But it is something to think about doing if you can.

Click on Our Link to read the posts
Blog
or go to:
http://rvaprostatecancersupport.org/PDF/PCa-Bone mets in Backbone Clinical Protocol to analyze Exercise benefits.pdf
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Us Too warriors (1/21/18)
Subject: Testosterone

Us Too Warriors, I just found my Testosterone which is usual Ultra high 650 to 950 over the years has gone up as expected to Ultra Ultra high at 1532. This Testosterone at 77 years is more than 3 times that of when I was diagnosed with PCa - which was 475. ( I had only thought it might go to 1200 on Casodex as a 30% rise is usually measured) This looks like a rise between 60% from 135% based on the usual base values. This amount of testosterone makes me feel really well.

I have attached some interesting clinic trial research at John Hopkins on raising and lowering testosterone alternately by injecting Testosterone and then ADT to drop it really low to try to kill CRPC cells with some success.

Click on Our Links to read the Data
Testosterone1
Testosterone2
Testosterone3

or Go To

https://www.sciencealert.com/a-man-s-prostate-cancer-has-completely-disappeared-after-unexpected-testosterone-treatment
http://www.ecco-org.eu/Global/News/ENA/ENA-2016-PR/2016/11/ENA2016-How-highs-and-lows-in-testosterone-levels-shock-prostate-cancer-cells-to-death
http://www.telegraph.co.uk/science/2016/11/30/man-cured-prostate-cancer-doctors-shock-tumour-death-testosterone/

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Us Too warriors (12/13/17)
Subject: Theranostics - Combining Imaging & therapy in the next 3 to 5 Years a Video by Dr Phillip Koo at MD Anderson Clinic

Us Too Warriors, It is Important to keep fighting your cancer with diet, spices, anti-oxidant polyphenols from color fruits and food along with anti-inflammatories like curcumin add exercise with health oils like olive oil plus throw in a few off label drugs use of anticancer drugs (I am know using 7 off label drugs) and I hope to be around in 2023 when the FDA approves the theranostic procedures shown in the Video attached below. I hope I will not need to go overseas to have access to the procedures which will be available in Europe and India sooner maybe 2 years.
All the best Peter

Click on Our Link to see the 17 minute Video
Theranostics
or Go To
https://grandroundsinurology.com/point-theranostics-prostate-cancer/
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Us Too warriors (11/19/17)
Subject: Yogurt, Milk Cheese and Ice Cream

The below provides information about Fruitose sugar and dairy's increase in PCa occurrence and growth. Also, milk contains a sugar called Lactose This type of information about dairy products made me stop eating and drinking dairy over 15 years ago and to avoid calcium supplements. I use higher doses of Vitamin D3 and Vitamin K2 to keep my bones health (high Bone Density) from knowledge from bone tissue engineering research with Broccolli my main source of calcium with the hope that high bone density will keep circulating.
Have a Good Thanksgiving,
Peter

Click on Our Link
Link: Milk Cheese Ice Cream
or Go To
http://rvaprostatecancersupport.org/PDF/11 18 18 Milk Cheese and Ice Cream3.pdf
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Us Too warriors (11/19/17)
Subject: New Shingles Shot

Warriors, It is recommended that you get this shot even if you have had the old type vaccine. It Should be available in the next one or two months at pharmacies. The shot is called Shingrix Vaccine.The live attenuated herpes zoster vaccine, which is the current vaccine used in the US, is only 70% effective in preventing herpes zoster for persons aged 50 to 59 years, 64% for those 60 to 69 years, and 38% for those 70 years of age or older. The new Shingrix vaccine was 97%, with little difference across age groups.

Click or copy these websites to your internet browser The first one is a video from Dr Snuffy Myers about the need for shingles, flu and pneumonia vaccines and second website discusses the new shingles vaccine:

Click on Our Link
"Dr Snuffy Myers"
or Go To
https://www.prostatepedia.net/blogs/ask-dr-myers/61782211-winter-vaccines-dangerous-to-miss

Click on Our Link
"New Shingles Vaccine"
or Go To
http://www.mdedge.com/fedprac/clinical-edge/summary/vaccines/cdcs-acip-recommends-new-shingles-vaccine?group_type=2-month&topic=311&channel=311&utm_source=ClinEdge_Power_eNL_111217_F&utm_medium=email&utm_content=ClinicalEdge%20Top%2010:%20Editor%27s%20Picks%20for%20November

I have had shingles twice in a period of 4 months in 2013 (once on each side of my body).. Fortunately, because of the anti-inflammatories etc, that I take and herbal research to add supplements to fight shingles specifically, my cases did not do permanent nerve damage and I recovered well as I only had pain from swelling knots in my scalp no open sores and I recovered relatively quickly. But My PSA started to rise quicker soon afterward the four months passed
All the Best
Peter Moon PhD
*
Us Too warriors (11/04/17)
Subject: Optimal Duration of Hormone Therapy With Radiation for Localized Prostate Cancer

RVA Us Too Warriors, The length of time for hormone therapy combined with Radiation treatment is a question that many men need to consider if they are considering this treatment combination. The website video below discusses some of the factors that influence this decision. I hope it helps you to consider what is best for you and your situation.

All the best Peter

Click on Our Link to see the 5 minute Video
Duration
or Go To
http://www.practiceupdate.com/c/54343/3/1/?elsca1=emc_enews_top-10&elsca2=email&elsca3=practiceupdate_onc&elsca4=oncology&elsca5=newsletter&rid=NTU2MjE4MTA4NzMS1&lid=10332481
*
Us Too warriors (10/21/17)
Subject: Vitamin D3

Us Too Warriors, This information about Vitamin D levels and several cancers shows the benefits of Supplementing with Vitamin D especially with winter coming on. The highest values of vitamin D in these graphs is low at above> 33ng/ml in the blood. Dr Myers likes it between 60 to 80 ng/ml. My gene analysis show I am a poor vitamin D absorber (~60% of normal absorption) so I take about 20,000 IU of Vitamin D a day to have level of about 100 ng/ml in my blood. Most people can take 5,000 to 10000 IU per day to get there blood level of Vitamin D in a good health range. The average supplementation in our group of 45 men responding was 8,666 IU. Most of the men taking less than 5,000 IU.per day were not in the range 60 to 80 ng/ml I have a no dairy diet to keep my calcium, sugar, fat and growth hormones from Milk /cheese low. I take Vitamin K2 in LEF.org "Super K " supplement to keep calcium absorption boosted by vitamin D out of my blood vessels.

I hope it this helps.

Click on Our Link to see the Charts
Vitamin D
or Go To
https://grassrootshealth.net/blog/vitamin-d-and-cancer-research/
*
Us Too warriors (8/8/17)
Subject: Vitamin D3

Us Too PCa Warriors, As many of you know Vitamin D3 acts as hormone in the body any effects many body functions as most cells have receptors for it (Brain, Muscles, Bones, teeth, heart, gut , auto immune system, immune system, and can add years to your life and life to your years. etc). Everyone needs to find the amount to get your blood level in the 60 to 80 ng/ml range to fight cancer on seeing the levels in this article with winter ahead we will need more with less sun. My gene analysis show I am poor absorb of vitamin D3 at only 60% 0f the average so I take 18,000 IU of D3 to get up to the 100 ng/ml in my Blood along with With Super Vitamin K (with K2 from Lef.org) and a low calcium diet to keep calcium out of my veins and put it in my bones to fight hardening of the arteries and prevent my bone metastases from PCa (and now melanoma). I have sent you this chart on Vitamin D, I receive from my many sources for information so you will be able figure out thu blood test what is a good dose for you without being scared of by Doctors saying High Vitamin D3 is toxic. The suppplementation has to be extremely high for a good period of time to be a concern.

A Dr. in Brazil is reversing or stopping Advancing Muscular Scoliosis with very high doses in the 40,000 to 100,000 IU per day with 4,000 patients treated in the last 10years titrated to the patient's response. I expect that many of these patients are very poor absorbers of vitamin D so that is why they developed this auto-immune disease. You can get Vitamin D measured by LEF.org (1-800-544-4440) fo about $35 without a Doctor by calling and arranging the details of the test at LabCorp blood Draw station around Richmond.

I hope it this helps.

Click on Our Link to see the Charts
Vitamin D3
or Go To
http://www.grassrootshealth.net/document/vitamin-d-toxicity/
*************************************************

Us Too warriors (5/23/17)
Most of you have heard me discuss at our meetings how vitamin D3 acts
as a hormone to prevent many cancers by acting in most of the cells in
the body if we can use supplements to get it into the 60 to 80ng/ml of
blood range. It is best used with vitamin K2 if you are not on blood thinners
to get the added calcium absorbed from Vitamin D supplementation deposited in
your bones and not your veins thus preventing osteoporous and hardening of
your arteries while slowing and preventing cancers- a real Trifecta!!!

The only way to tell is by 25(OH)D blood tests which can be gotten for a
reduced rate~$35 before June 6 th at LEF.org or calling 1-800-544-4440 to
sign-up and pay for the test thru a blood draw at a local LabCorp Blood draw
clinic locally in Richmond (no Doctor needed but not covered by insurance).
Vitamin K2 supplements can obtained as Super Vitamin K from LEF.org. My
genetic analysis thru 23 and Me and Promethease.com show I am poor vitamin D
absorber(~60% of average) so I need twice the supplement level to get my blood
levels the same as my wife's. The average Vitamin D3 supplement level in our
group as reported to me in 2011 by 60 men was 8660 IU.

But only about half of the men taking the high levels close to 10,000 IU were
able to get into 60 to 80 ng/ml range. We all differ in our absorption and
metabolism of Vitamin D so you could take between 5,000 to 10,000 IU per day for
three months and have a blood to see where you are and increase or decrease your
blood levels as needed. You can get your blood tested up to 6 months after you pay for it with no problem. I buy multiple blood test which I can use after 6 months by
asking for an extension which they( LEF.com) have given me by sending new paper work extending the draw date.

In report of the level Vitamin D of 6000 men older than 50 years old tested(2011) at VCU about 35 percent where deficient (<20 ng/ml) and 40% more where insufficient (<30ng/ml).

If your skin is pigmented even a little more than that of a caucasian it has big effect on your chance of vitamin D deficiency from its lack of production from sun
exposure. See copied graph below. The resulting ill effects on health besides those above are: heart, muscles, brain, auto immune diseases, Lungs/respiratory, ,
frailty, aging and longevity "Etc, Etc, Etc!!!"*

*Quoted from The King and I.

All the Best, Peter
***************************************************
Us Too warriors (4/28/17)
In 2011, I surveyed our group on Vitamin D3 Use and found the average dose of the 60 responders
was 8,660 I.U. of vitamin D3/day. Of these men, 80% were above 40ng/ml of blood and 10% above 75 ng/ml
to 100ng/ml. The Men below 40ng/ml used less than 3000 IU of Vitamin D3 and the men with 75 to 100ng/ml
used 10,000 to 15,000 IU of Vitamin D3/day.
Peter

Low vitamin D status is associated with inflammation in patients with prostate cancer.
Link: Vitamin D3
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Us Too warriors (4/21/17)
Us Too Warriors, Information about infectious biopsy and radiation treatment you can use.
Peter

Clinical comparison of the efficacy of three different bowel preparation methods on the infectious
complications following transrectal ultrasonography guided prostate biopsy in nursing practice.
Link: infectious
*
Us Too Warriors, I have been able to save about $1000 a year by using "Express Scripts" for about 5 years during which time I was on Anthem while working and now on Medicare while working part time. I have been able to sign my son, an elementary School teacher in newport news and my brother on medicare. An example of the savings:CVS wanted $180 for 30 days of an antibiotic for my brother But express scripts only charge $7 dollars for 90 days of the same pill.

Most of my prescriptions cost $7 for 90 days. The number to call is 1-800-572-4098 and ask to speak to an operator. You may already be in their system . My son was. Ask them any questions you have about how it operates. They have my charge card on fill to pay for the pills. You have to have your doctor send the prescription electronically to Express scripts for you. When I was working they would automatically send refills my prescription before I ran out as long as I had refills left. But now on medicare I have remember to cal in the prescription about 9 days before I run out to get it in time. There is no charge for mailing.

Give it a try you will like the convenience of not waiting to get your prescription filled at the local pharmacy.

Click on Our Link for the Website
"Express Scripts"
or Go To
https://www.express-scripts.com/index.html
*
UsToo Warriors, This new imaging technique [Fluciclovine F18] became available as September 15, 2017. It has the potential of detecting my PCa recurrence sites at more than 85% level compared with less that 5% chance. with CT of the prostate bed and bone scans. It may not work as well if you are on ADT as the detection radioactivity is best absorbed in rapid/aggressive cancers and if the ADT is working the cancer will be slowed. It still I believe involves the higher radiation of a CT scan.

I am still investigating it to see if I want to do it. My problem is that I do not like/want most of the treatments that are standardly used to treat recurrent PCa after surgery. The only ones I might consider if I could find a qualified Doctor to pursue would be precision radiation (radiation Knife) to only bone or lymph node lesion or laser focal therapy to prostate bed etc.

Notice: this Imaging technique may light up other cancers beside PCa present which may be good or confusing until the kind of cancer is known??? For example it may light up a melanoma metastasis if I have one???

It is not a good idea to have imaging tests done unless you know how you can use the information to guide (improve) treatment or to see if the treatment is effective (only if there is a not less invasive way) . The ill effect of extra radiation from imaging has to be weigh against the usefulness of the information obtained.

See the attached video to find out about this new imaging ability at detection. I will try to talk more about this at coming meetings. Next meeting is Thursday Sept 21 st 7 PM.

All the Best, Peter

Click on Our Link to read more
Fluciclovine F18
or Go To
https://www.urotoday.com/journal/everyday-urology-oncology-insights/articles/92386-everyday-urology-axumin-fluciclovine-f18-an-accurate-imaging-approach-for-patients-with-biochemically-recurrent-prostate-cancer-full-text-article.html

*
Us Too Warriors, I have decided not to get the CT trunk scans and bone scans my doctor recommended because my cancer is not bad enough to be detectable by CT scans which produce radiation equal to 300 t0 500 chest X-rays.

It is expected that CT scans will produce 30,000 cancer deaths each year (more than the number who die from prostate cancer) 2% of all cancer deaths each year.

Before getting a CT scan be sure it is necessary and is good enough to detect your cancer as it presents itself in your body ( based on PSA level and the rate of doubling time see the information below)

You may have to wait for your cancer to get worse before you can detect it. I had to wait 15 years for my PSA get to 2 before I got a MRI to detect an 8mm ball in my prostate bed 23 years after Surgery.

Three year later and a PSA of 9 a CT scan would still not detect the cancer in my prostate bed or anywhere else in my body. MRI is much better in detecting small amounts of Cancer. I had a CT bone scan twenty four years ago, it did not detect anything and it would not be able to detect anything today because my cancer is not bad enough. 100 million dollars are wasted each year and 3 million people are exposed to cancer causing radiation with no benefit. Multiple scans rapidly compound the danger of radiation cancer.

Until my cancer gets worse, I will investigate the use of MRI to detect bone metastasis.

Please read the information below so you can be informed and protect your health..

All the best, Peter

Click on Our Link to read more
Informed
or Go To
http://rvaprostatecancersupport.org/PDF/American College of Radiology ACR Appropriateness Criteria update 2011.pdf

*
Us Too Warriors, It Is General Recognized That Radiation Therapy To The Prostate And Localize Bed For Pca Cure Increases The Chances Of 2nd Cancers In Radiated Areas. However - This is The First Paper That I Am Aware Of That Suggests Similar Concerns With Brachytherapy. If You Have Or May Plan To Have This Treatment - I Suggest You Pay Close Attention To The Symptoms Of The 2nd Cancers Describe So If They Do Occur You Can Catch These 2nd Cancers While They May Still Be Cured.

Click on Our Link to read The Article
Brachytherapy
or Go To
https://www.ncbi.nlm.nih.gov/pubmed/28882777

All the best.
Peter
*
US Too Warriors, I am going for a CT scan to see if they can find why my PSA is Going up??? I am not a fan of CT scans. I do not think they have good resolution and too much radiation that may be cancer causing in time.

See below for ways to protect yourself from radiation from The CT scan. As we age, we will be asked to have more CT scans to help the doctors find out what ails us. Please take precautions as outlined below to keep from having more cancer problems.

Click on Our Link to read The Article
CT Scan
or Go To
http://www.lifeextension.com/Magazine/2010/8/Protect-Your-DNA-from-CT-Scans-X-rays/Page-01

All the best.
Peter
*

Us Too Warriors, I had good News that the melanoma had not gotten to my sentinel lymph node form the pathology report. But my PSA doubling time has dropped to about 6 months which suggests I am going to re-examining my course of action which has worked well for the last 18 years. This is not unexpected in fact I have very pleasantly surprised it has taken this long to start to progress more rapidly. My strategy has been to survive long enough for research to develop some promising treatments as we have seen in the last few years. I am going to take advantage of them now to find out what I can about my cancer and how the treatments I choose will benefit it or not.

My first test will be for Circulating tumor cells(CTC) - which will show the # of these cells in 7.5 ml of blood. If the cells are less than 5 the survival is favorable. So I will check cell numbers now to know for a baseline and after 3 months of treatment to see if the treatment is working by lowering the number of circulating cancer cells. A new treatment is yet to be decided but I expect it to be Casodex. If I see signs of PSA increasing after I have been on treat for a while assuming the treatment works to bring down the PSA as expected, I will get additional CTC test to see what is going on.

Information about the CTC tests can be found at this website:

Click on Our Link to read more
CTC
or Go To
https://www.cellsearchctc.com/about-cellsearch/what-is-cellsearch-ctc-test

All the best.
Peter
*
Us Too warriors (8/29/17)
Subject: Okra

Us Too Warriors, The Okra seeds seem to contain lectins and the pod pectins that seem to act against PCa and other cancers.. Okra is also supposed to be beneficial in diabetes.
Click on Our Link to read more
Orka
or Go To
http://www.edenprescription.com/Okra.html
All the best
peter

*
Us Too warriors (8/21/17)
Subject: Prediabetes

Sugar's average level over several months in the blood is measured by A1c level from a blood draw.
High A1c may be a sign prediabetes type 2 or full type 2 if high enough. This sugar in the blood is a big promoter of cancer growth so it is the reason we need to minimize sweets and candy. It also increases aging in general. The List below are some supplements that can lower A1c = average blood sugar.
Click on Our Link to read more
Prediabetes
or Go To
http://rvaprostatecancersupport.org/PDF/A1c.pdf
All the best peter
Peter
*
Us Too warriors (8/21/17)
Subject: Stereotactic Radiation Treatments

This stereotactic radiation treatment looks very effective for men not concern with cancer escaping the capsule - not too far advanced. I do not see from the abstract the incidence of side effects but I think they should be less than in typical large treatment fields with higher dose and more applications. You will need to pull up the complete paper at the end to see if the evaluate these effects.
Click on Our Link to read more
Stereotactic Radiation Treatments
or Go To
http://rvaprostatecancersupport.org/PDF/HOMERECENT ABSTRACTS UROLOGIC ONCOLOG.pdf
All the best peter
Peter
*
Us Too warriors (8/8/17)
Subject: Anti-angiogenetic Foods

Look at some food in the list below for possible selections to bring to our Pot Luck Dinner and to add to your diet to fight cancer. See Attachments below for more Ideas on how to fight your cancer by using food as medicine.

According to Li, resveratrol from red grapes, for example, have been shown to inhibit abnormal angiogenesis by 60 percent. Even more potent is the ellagic acid found in strawberries.

Other anti-angiogenetic foods include:
Green tea - Berries: strawberries, blackberries, raspberries, blueberries,Cherries - Red grapes - Kale - Turmeric - Nutmeg - Artichokes - Parsley - Garlic - Tomato - Maitake mushroom

Logically, different foods contain different potencies of anti-angiogenetic compounds. But interestingly, when researchers evaluated a combination of two of the LEAST potent teas, for example, they discovered that this combination tea had greater potency than any given tea by itself. Click on Our Link to read more
Anti-angiogenetic Foods
or Go To
http://articles.mercola.com/sites/articles/archive/2010/06/08/dramatically-effective-new-natural-way-to-starve-cancer-and-obesity.aspx
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Us Too warriors (7/31/17)
Subject: Bromelain and Quercetin - The research paper and links below give you the information you need to fight your cancer.

Click on Our Link to read more on Quercetin
Quercetin
or Go To
http://prostate.net/articles/quercetin-for-prostate-cancer
Click on Our Link to read more on Bromelain
Bromelain
or Go To
http://www.lifeextension.com/Vitamins-Supplements/item01203/Specially-Coated-Bromelain
*
Us Too warriors (7/12/17)
Subject: Red Meats - This research shows that red meats are a problem if you are prone to cancer. And if you have cancer it makes no sense to eat the little amount they think is okay- It is not. Also meat cooked or burnt at high temperatures is more carcinogenic!!!! Red meat adds to heart disease which often accompanies prostate cancer as the same bad diet fuels both.

Stay Cool and drink plenty of water!

Click on Our Link to read more on cancer, Diet and Red Meat
Red Meat
or Go To
http://rvaprostatecancersupport.org/Red Meat.pdf
*
Us Too warriors (6/20/17)
Subject: At the last meeting, I reported on My Brother's Visit to Dr. Myers and the lowering of his PSA with Milk Thistle after there was an up tick in his PSA on Xtandi and other big $$$$ cancer drugs. Dr. Myers asked which source of Milk Thistle he used (Which was European milk Thistle from LEF.org). He also Indicated when he retires - he will be studying and writing on these supplementary treatments. Dose effect was evident as PSA went down on two pills per day, but started up again when my brother dropped to only one pill and at 1 1/2 pills (two pills one day and 1 the next) it went down again. (PSA taken every 30 days). I have taken 3 European Milk thistle pills every day for 7 years.

He indicate he was very interested in a supplements containing Ursolic acid such as Apple peels, Rosemary and Basil. I eat apples every day and add the spices to my stir fry. Grape seed extract is good too.

You the may find these two links of interest. My Niece sent me the first one.

Click on Our Link to read
Curcumin, Ursolic-Acid, Resveratrol
or Go To
http://www.medicalnewstoday.com/articles/317977.php
Click on Our Link to read
Ursolic-Acid
or Go To
https://examine.com/supplements/ursolic-acid/
*
Us Too warriors (6/12/17)
Subject: Website with Discussion of mTOR cancer growth pathways and Natural supplements which act as mTOR cancer growth inhibitors

US Too Warriors, I hope you can make the next meeting as we will not have another until August for out potluck supper.
I have added the website below which discusses Blocking the mTOR Cancer pathway in which you will find that many of the natural
supplements that a lot of us take can have a beneficial effect in blocking this cancer growth pathway. I will try to explain
this when I discuss my brothers treatment by Dr. Myers along with two other men with advanced PCa who will discuss their treatments.
Click on Our Link to read more on mTOR Cancer pathway
mTOR
or Go To
https://selfhacked.com/2014/11/03/mtor-natural-mtor-inhibitors/

And

The liver performs over 500 life-sustaining functions, including neutralizing toxins.
Milk thistle, a plant native to the Mediterranean regions, has long been prized as a treatment for chronic liver ailments.
Human and animal studies are confirming these benefits.
Click on Our Link to read more
Milk thistle
or go to:
http://www.lifeextension.com/Magazine/2016/5/Mediterranean-Herb-Guards-Vital-Liver-Functions/Page-01
*
Us Too warriors (5/29/17)
Please find some papers below on off label drugs I have found helped me to slow my PSA rise after PCa
recurrence in 1999. I have used them for the times as follows: Metformin for about 2 years, dutasteride
and finasteride for 17 years, and doxycycline about 10 years. I have just sent these papers that were
requested by my second brothers GP Doc who has just prescribed them for him after I went with him to the
Doctor. My 2nd brother has arising PSA with a doubling time of 2.7 years - the same for the last two years
(this year's recent PSA is 2.8 and at this rate it will be 4.0 next year. Biopsy time. We will probably get
an MRI after we see what his PSA does 3 months on this complementary threatment. If you want to know more
about the dose levels email me. My First brother, (who Surgery 24 years ago and recurrence 10 years ago)
sees Dr. Myers has been doing well on Advance cancer treatment (Xtandi, Leukine, Metformin and Firmagon plus
supplements) I hope My brothers they will be at our next meeting June 15 th.

All the best - Peter

Doxycycline and other tetracyclines in the treatment of bone metastasis - Links: Doxycycline
MMP inhibition in prostate cancer - Link: Doxycycline MMP
The Rationale for Inhibiting 5α-Reductase Isoenzymes in the Prevention and Treatment of Prostate Cancer - Link: Reductase
Finasteride Inhibits Human Prostate Cancer Cell Invasion through MMP2 and MMP9 Downregulation - Link: Finasteride
Metformin use and Prostate Cancer Risk - Link: Metformin
*
Us Too warriors (5/29/17)
I am seeing discussions to the effect that if you do not kill the cancer with your treatment
you may make it stronger by selecting survival of the Strongest cell cancer cells.

At our last meeting there was a discussion of the Advanced treatments like Provenge, Xtandi and
Xytiga. They are new and not full understood or explored.

However, the attached file does a good job of point out what the oncologist are thinking know.
I think it makes sense to know about them and how they work to be prepared. And pray we will not need to
use them but to be thankful they are there if we do.

All the best - Peter
Links: Question
Links: More Questions
*
Us Too warriors (4/17/17)
As some of you may know, I have had some issues with my Kidney function recently
such as higher blood pressure, high creatinine, high homocysteine and low GFR.

These are all signs that my kidneys are not doing a good job filter waste products out of my blood.
Age isa factor in kidney filtration I have cut back on salt and protein and increased water intake.
There has been a modest improvement.

I am seeing a kidney Dr. today to find out more. PCa metastasis to kdneys is rare. But Hormone therapy
which I am not on yet may be concern if you are on it. see the following report.

I hope to see you at the meeting thursday.

All the best Peter

Kidney Failure a Possible Risk of Prostate Cancer Hormone Treatment: Study
Link: Kidney Failure

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Us Too warriors (4/18/17)
Anesthesia is something to consider with prostatectomy. I felt I experienced loss
of spacial memory for a period after PCa surgery in which it was hard for me to visually
recall road connections i wanted to take to get me around Richmond in the years after surgery.
It is not much of a problem now.
Peter

Cognitive Decline After Surgery Tied to Brain's Own Immune Cells
Link: Cognitive Decline

***********************************************
RVA US-Too - 7:00 PM - Apr 20, 2017.

Us Too Warriors - Subject: "Block MMPs to Inhibit Metatasis and an Abstract on Minimizing
Dairy"

Us Too warriors, Our next meeting will discuss research on how MMPs can be blocked to
prevent metastasis. I hope you can make the meeting.

Below you will find an abstract outlining how dairy products (milk,cheese, yoguart etc) can
increase insulin related growth factors for prostate cancer. I often drank 2 quarts of milk
and much sharp cheese a day. But I have avoided all dairy for the last 17 years since my
cancer reccured. it would be wise to minimize your intake also.

All the Best
Peter

*
Click on Our Link to Download the Handouts and read about Red Berries & reduced Inflamation

Prostate Cancer Progression
PCancer Progression

Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Prostate Cancer Progression
PCancer Progression Natural Inhibitors

How red berries reduce Inflammation
Red Berries

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Does milk intake promote prostate cancer initiation or progression via effects on insulin-like
growth factors (IGFs)? A systematic review and meta-analysis.

To establish whether the association between milk intake and prostate cancer operates via the
insulin-like growth factor (IGF) pathway (including IGF-I, IGF-II, IGFBP-1, IGFBP-2, and
IGFBP-3).

Systematic review, collating data from all relevant studies examining associations of milk with
IGF, and those examining associations of IGF with prostate cancer risk and progression. Data
were extracted from experimental and observational studies conducted in either humans or
animals, and analyzed using meta-analysis where possible, with summary data presented
otherwise.

One hundred and seventy-two studies met the inclusion criteria: 31 examining the milk-IGF
relationship; 132 examining the IGF-prostate cancer relationship in humans; and 10 animal
studies examining the IGF-prostate cancer relationship. There was moderate evidence that
circulating IGF-I and IGFBP-3 increase with milk (and dairy protein) intake (an estimated
standardized effect size of 0.10 SD increase in IGF-I and 0.05 SD in IGFBP-3 per 1 SD
increase in milk intake). There was moderate evidence that prostate cancer risk increased
with IGF-I (Random effects meta-analysis OR per SD increase in IGF-I 1.09; 95% CI 1.03,
1.16; n = 51 studies) and decreased with IGFBP-3 (OR 0.90; 0.83, 0.98; n = 39 studies), but
not with other growth factors. The IGFBP-3 -202A/C single nucleotide polymorphism was
positively associated with prostate cancer (pooled OR for A/C vs. AA = 1.22; 95% CI 0.84,
1.79; OR for C/C vs. AA = 1.51; 1.03, 2.21, n = 8 studies). No strong associations were
observed for IGF-II, IGFBP-1 or IGFBP-2 with either milk intake or prostate cancer risk.
There was little consistency within the data extracted from the small number of animal studies.
There was additional evidence to suggest that the suppression of IGF-II can reduce tumor size
and contradictory evidence with regards to the effect of IGFBP-3 suppression on tumor progression.

IGF-I is a potential mechanism underlying the observed associations between milk intake and
prostate cancer risk.

Cancer causes & control : CCC. 2017 Mar 30 [Epub ahead of print]

Sean Harrison, Rosie Lennon, Jeff Holly, Julian P T Higgins, Mike Gardner, Claire Perks, Tom
Gaunt, Vanessa Tan, Cath Borwick, Pauline Emmet, Mona Jeffreys, Kate Northstone, Sabina
Rinaldi, Stephen Thomas, Suzanne D Turner, Anna Pease, Vicky Vilenchick, Richard M Martin,
Sarah J Lewis

*********************************************
Evidence based Complementary and Alternative medicine

Here is a search I made - Please use this to see if you can find an additional way to help fight your cancer.
Just click on the article title line and you will moved to the article. There are 27 Articles. All the best peter

Title Example:
Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent
Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis,

Click the link to go there.

Alt. Med

or go to:
https://www.hindawi.com/search/title/prostate+cancer/or/abstract/prostate+cancer/and/journal/evidence+based+complementary+and+alternative+medicine/

*
PAN Foundation

The copay assistance program for individuals with metastatic prostate cancer has just opened at the Patient
Access Network (PAN) Foundation. This is a great potential opportunity for eligible men affected by metastatic
prostate cancer to receive up to $12,000 a year in financial assistance.

For more information visit:

Click on Our Link to read more

PAN

or go to:
http://bit.ly/2n1SftA

You may apply online or call 1-866-316-7263.

*
Us too warriors

Doctor's payments from drug companies can influence doctors - even though the amounts may be relatively small.
Doctors are human even if we treat them as super humans or gods. If someone ie.(Company) treats them with a
favor(read =free product, device or money) they will tend to respond favorably in use or recommendation of
the company’s product with their patients. Some of these payments are for food so a company representative
can inform them over a meal about their product, how to use it and is one of the ways doctors stay informed.

Peter

Article:

Two-thirds of Americans see docs who got paid by drug companies: Study
Drexel University Health News, 03/16/2017

About 65 percent of those surveyed as a part of the study by Genevieve Pham–Kanter, PhD, an assistant professor
in Drexel’s Dornsife School of Public Health, visited a doctor within the last year who had received payments or
gifts from pharmaceutical or medical device companies. What’s more: Only 5 percent of those surveyed knew that their
doctor had received such payments.

Click on Our Link to read more

Article

or go to:
https://www.mdlinx.com/family-medicine/medical-news-article/2017/03/16/doctors-payments-from-drug-companies/7087462/

Has Your Doctor Received Drug or Device Company Money?

Click on Our Link to find out

Money

or go to:
https://www.mdlinx.com/family-medicine/news.cfm

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What It’s Like to Be Part of a Prostate Cancer Support Group

Advocacy - We speak with two specialists from a prostate cancer support group about the ways this
experience empowers men and their loved ones.

Stigma continues to surround men’s health in general, and prostate health in particular.
Having a support network, however, can help to curb these threats. Terri Likowski and Ken Wilmarth
from Us TOO’s support group open up about the ways an organization like theirs can give
members a bedrock of information — and hope.

Click on Our Link to read more

Support Group

or go to:
http://www.futureofpersonalhealth.com/advocacy/what-its-like-to-be-part-of-a-prostate-cancer-support-group

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Scientists use new 'blood biopsies' with experimental device to speed
cancer diagnosis and predict disease spread.

Researchers are using a new blood-analysis technique and tiny experimental device to help physicians predict
which cancers are likely to spread by identifying and characterizing tumor cells circulating through the blood.

Click on Our Link to read more

Blood Biopsies

or go to:
https://www.sciencedaily.com/releases/2017/02/170213091131.htm

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Life Extension Magazine

How to Reverse Markers of Prostate Cancer.

Despite prostate cancer being the second leading cause of cancer death in men, a raging debate has ensued as
to whether men should have annual PSA blood tests. The scales are tilting in favor of Life Extensionï¿½’s
multi-decade campaign to educate men about the importance of regular PSA screening. Not only are there proven
ways to reverse rising PSA levels, but breakthrough treatments can enable safer diagnosis and curative treatment
without the side effects associated with conventional surgery and radiation.

To Read The Articles - Click on Our Link

Life Extension Magazine

or go to:

http://www.lifeextension.com/Magazine/2016/6

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URO Today
Your Urology News and Education Resource.

Here you will find Articles, Videos Lectures, Clinical Trials and more. All are Choice topics on Immunotherapy.
Look Around the site & find the Topic that suits your needs by clicking on their links.

UroToday always offers free, open access to all site content - Enter your email address to sign in and
they will send you an Email link to sign in with.

To Read The Articles - Click on Our Link

URO Today

or go to:

https://www.urotoday.com/

Meeting Information for Dec 8 2016

After the Us Too dinner on 12/8/2016 there will be a discussion on
"Preventing PCa Metastasis by Blocking MMPs

To get up to speed - Read the below - Click on Our Link

MMPs

or go to

href="http://www.jamersonscrafts.com/Pictures/PDF/Prevent PCa Metastasis by Blocking MMPs.pdf

Meeting Handout for Nov 17 2016

Us Too Warriors, We hope you can come to the meeting and bring
a copy of the handout covering ADT and its Possible Problems:

Cognitive – Depression, Stress, Alzheimer’s, Parkinson’s increase, Headache
Metabolic- Weight gain, Muscle mass loss, Fat mass up, Lipids LDL +/HDL -, TriGly. +, Diabetes
Physical- Fatigue, Muscle weakness, Falls, BMD -, Fractures, B. +, Sex organs –, ED, Hot Flashes
Heart - Heart disease ~+20 to 40 % if already precent, Diabetes, Insulin resistance.

To Read and print this Handout - Click on Our Link

Handout

or go to
href="http://www.jamersonscrafts.com/Pictures/PDF/Us Too Warriors Nov17 2016.pdf